Codeage Immune Liposomal NMN Review
Codeage Liposomal NMN is a supplement featuring Nicotinamide Mononucleotide (NMN), a NAD+ precursor, combined with TMG (Trimethylglycine). It utilizes a liposomal delivery system with phosphatidylcholine from non-GMO sunflower oil to enhance absorption.
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Study, Trial or Testing Result Summary
Members Only12 human studies · 8 improved
Neither ingredient in this product is present at the amount used in the studies. Nicotinamide mononucleotide is included at about 207.5 milligrams a day, well below the doses tested. In a placebo-controlled trial of 42 hospitalized adults with the coronavirus illness and kidney injury, 2 grams a day for 2 weeks safely raised blood levels of the cell fuel it is meant to boost, but inflammation markers, kidney injury markers and illness severity were no different from placebo [1]. In 25 adults with an immune disorder that destroys blood platelets, 450 milligrams twice a day for 2 weeks was well tolerated. Only 20% reached the main platelet target, though 60% rose above one and a half times their starting count at some point. There was no comparison group [2]. A laboratory study found it did not boost a type of calming immune cell [3]. Betaine is present only in a trace amount, 42.5 milligrams compared with the 2 grams studied. In 29 youth soccer players, 2 grams daily for 14 weeks kept inflammation signals lower and prevented a rise in white blood cells compared with placebo [4]. A broad review said betaine may lower inflammation markers but gave no specific doses [5]. In colorectal cancer patients, eating more betaine in food was linked to a higher inflammation marker [6]. Animal and cell studies are never counted.
See all 12 studies →Hide the studies
- A review of 49 articles on many nutrients and diets reported that betaine, among other nutrients, can lower blood markers of inflammation and oxidative stress, but it gave no betaine-specific doses or results.[Effect of nutrition on human inflammatory and oxidative stress markers].
- In 42 hospitalized adults with COVID-19 and acute kidney injury, 2 grams a day of NMN for 2 weeks safely raised blood NAD levels, but inflammation markers (CRP, IL-6, TNF-alpha), kidney injury markers and disease severity did not differ from placebo.Oral MIB-626 (β Nicotinamide Mononucleotide) Safely Raises Blood Nicotinamide Adenine Dinucleotide Levels in Hospitalize…
- In 29 professional youth soccer players, 2 grams of betaine daily for 14 weeks kept inflammatory signals (TNF-alpha, IL-1 beta, IL-6) lower and prevented a rise in white blood cell counts compared with placebo over a competitive season.Effects of 14-weeks betaine supplementation on pro-inflammatory cytokines and hematology status in professional youth so…
- In a single-arm open-label trial of 25 adults with a med-refractory or a med-dependent immune thrombocytopenia, 450 mg of oral NMN twice daily for 2 weeks was well tolerated; 20% reached the primary platelet-response target, and 60% reached platelet counts above 1.5 times baseline at some point during treatment.Low-dose oral nicotinamide mononucleotide for immune thrombocytopenia: a phase 1/2 trial.
- In cancer patients in Hungary, higher betaine intake from food was linked to higher levels of the inflammatory marker IL-8 in colorectal cancer patients, and the study did not test betaine supplements.The Effect of Dietary Methyl-Donor Intake and Other Lifestyle Factors on Cancer Patients in Hungary.
- In a mouse model of immune thrombocytopenia and in patient immune cells, nicotinamide raised regulatory T cells and helped platelet counts, but nicotinamide mononucleotide did not promote regulatory T cell development.Nicotinamide enhances Treg differentiation by promoting Foxp3 acetylation in immune thrombocytopenia.
- In mice with spontaneous Sjogren's disease, nicotinamide mononucleotide restored mitochondrial function, reduced salivary duct injury and lowered immune cell infiltration.Mitochondrial-impaired ductal epithelium fuels TLS formation in Sjögren's disease.
- In young and elderly mice, nicotinamide mononucleotide increased the cell-killing activity of natural killer immune cells, though not their number, and this effect depended on interferon gamma.Nicotinamide mononucleotide augments the cytotoxic activity of natural killer cells in young and elderly mice.
- In mice with silica-induced lung injury, nicotinamide mononucleotide reduced lung damage and oxidative stress, increased glutathione, and lowered inflammatory cell recruitment at 7 and 28 days.Nicotinamide Mononucleotide Ameliorates Silica-Induced Lung Injury through the Nrf2-Regulated Glutathione Metabolism Pat…
- In mice, sleep deprivation weakened the gut's ability to resist intestinal infection, and nicotinamide mononucleotide supplementation restored this protection, partly by restoring gut bacteria that produce deoxycholic acid.Nicotinamide Mononucleotide Ameliorates Sleep Deprivation-Induced Gut Microbiota Dysbiosis and Restores Colonization Res…
- In mice, nicotinamide mononucleotide improved survival from a hypervirulent Klebsiella pneumoniae bloodstream infection, reduced inflammatory signaling and liver inflammation, and helped block liver abscess formation when combined with meds.β-Nicotinamide mononucleotide protects against hypervirulent Klebsiella pneumoniae bloodstream infection and liver injur…
- In mice with colitis, supplementing nicotinamide mononucleotide restored levels of the cell fuel nicotinamide adenine dinucleotide and eased colitis symptoms, with inflammation reduced when the enzyme CD38 in macrophages was removed.Macrophage-derived CD38 mediates colitis through NAD+ depletion.
Review Totals and Summary
Members Only3,868 reviews · 90% positive
Real user feedback on Codeage Immune Liposomal NMN is overwhelmingly positive, with many reviewers expressing high satisfaction with the product. Across platforms like iHerb, Codeage’s own website, Target, and Grove, users consistently comment on the perceived boost in energy and improved overall wellness after taking this supplement. Several customers remark that they feel more alert and notice enhanced stamina throughout the day, which seems to be a recurring benefit mentioned in many of the five-star reviews. Some users highlight subtle improvements in their immune system support, mentioning fewer seasonal illnesses since starting the supplement, while others appreciate the convenience and ease of incorporating it into their daily routine. Taste, when mentioned, is generally found to be neutral to pleasant, which is notable for a product in this category, and packaging quality receives favorable mentions for being easy to store and use. Another common theme is trust in the Codeage brand, with users feeling confident in the product's consistency and visible results compared to alternatives they've tried. However, the neutral and negative reviews, while a small percentage, should not be overlooked. Some users are less convinced about the supplement’s effectiveness, mentioning that they did not observe significant changes even after regular use over several weeks or months. A few reviewers express skepticism about the value for money, questioning whether the results justify the price point, especially since benefits can take time to manifest or may vary individually. There are also isolated reports of mild digestive discomfort, though these are not widely echoed in the broader feedback. On the whole, most users seem pleased with the overall quality and results, whereas the most frequent critiques center around unremarkable or slow-to-appear benefits. Despite the predominantly positive reception, these mixed experiences highlight that, as with many supplements, individual results may vary. Still, with the large majority reporting favorable experiences, Codeage Immune Liposomal NMN stands out to many as a worthwhile addition to their wellness routines.
Biohacker Summary
Members Only9 of 10 recommend it
The main ingredient here is betaine, and eight of the ten panelists spoke about it: five recommend it, one uses it, and two stay neutral. Most take it as betaine hydrochloride with meals to raise stomach acid, ease bloating, heartburn and indigestion, and help break down protein, with one suggesting up to three a day, one per meal, and another saying to start with one or two and adjust. Others value it as plain betaine (also called trimethylglycine) for supporting methylation, liver function, insulin sensitivity and fat burning, or for exercise power and as an option for people who do not respond to creatine, at 1 to 3 grams a day, and one takes it before an NAD drip to avoid stomach upset. One caution is to avoid it with a stomach ulcer, and some prefer getting it from foods like beets and spinach. NMN is a smaller ingredient in this product, and the panel is split on it, with some recommending or using it, while two stopped and one warned of side effects such as higher homocysteine.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Betaine · uses
- States he added 500 mg of betaine to his creatine product because it helps the body make more creatine.
- Recommends betaine hydrochloride for constant bloating and gas, especially if it's due to low stomach acid.
- Recommends taking betaine hydrochloride if an antacid was taken.
- Recommends betaine hydrochloride for heartburn or indigestion, stating it increases stomach acidification and can be taken in multiple pills before a meal.
- States that Betaine hydrochloride can help to restore stomach acid, but warns it should be avoided if one has a stomach ulcer.
- Betaine hydrochloride is an amino acid found naturally in foods, including beets, spinach, beef, and shrimp. It's an excellent natural remedy for increasing stomach acid. Dr. Eric Berg recommends consuming either betaine hydrochloride or apple cider vinegar before each meal.
- Recommends Betaine hydrochloride for heartburn and indigestion, stating it helps acidify the stomach and keep the valve at the top of the stomach closed.
- Suggests that increasing stomach acid with things like betaine hydrochloride could be a solution for acid reflux.
- States that Betaine hydrochloride can help to restore stomach acid, but warns it should be avoided if one has a stomach ulcer.
- Recommends betaine hydrochloride as one of the best ways to re-acidify the stomach, but warns against its use if one has gastritis or an ulcer.
Thomas DeLauer · Betaine · recommends
- Would start taking trimethylglycine (TMG), also known as betaine, due to increasing evidence of its benefits for insulin resistance and its ability to increase fat oxidation.
- Recommends TMG (trimethylglycine or betaine) for improving body composition and insulin sensitivity, and for supporting methylation pathways that keep the endothelium healthy, complementing the shear stress benefits of walking.
- Recommends TMG, also known as betaine, to aid the liver's ability to clear excess cortisol from the system.
- Highlights trimethylglycine (betaine) from beets as a powerful methyl donor that helps the liver break down homocysteine, takes the load off the liver, and is required for carnitine creation, which is crucial for fat burning and addressing fatty liver.
- Highly recommends TMG (trimethlycine or betaine), found in beets or as a supplement, because it's a methyl donor that aids in methylation in the liver, which is required for bile acid synthesis and phase 2 detoxification.
- Cycles TMG (trimethylglycine or betaine) on and off, doing four weeks on and four weeks off, because it helps lower the toxic load on the body, aids in methylation, improves insulin signaling, mitochondrial function, brain function, and has been shown to reduce hepatic triglycerides, liver fat, and increase muscle mass while decreasing fat mass.
- Recommends two to four grams of trimethylglycine (TMG or betaine) to help take a lot of stress off the liver.
- Recommends 3-4 grams of trimethylglycine (betaine) to help regulate homocysteine, which allows the body to deal with insulin resistance better.
- Recommends TMG (trimethylglycine or betaine) as a compound that works well with walking at a cellular level to detoxify the system, amplify energy production and fat loss, and course correct insulin resistance. He suggests a dose of 1.5 to 6 grams per day.
- Recommends TMG (trimethylglycine or betaine) for fat loss and muscle growth, citing studies that show it can prevent the formation of white adipose tissue, increase mitochondrial biogenesis, improve insulin resistance, and reduce total fat mass while increasing or maintaining lean body mass. He suggests taking it pre-workout to induce more fat burning and prevent fat accumulation later in the day.
- Is a big fan of nicotinamide mononucleotide (NMN) and feels it helps with energy manufacturing from an insulin resistance perspective.
- Warns that NMN and NR, which cost about 100 times more than nicotinamide and niacin, are likely broken down into the cheaper forms in the gut, suggesting no good reason to buy the expensive versions.
- States he will take Nicotinamide Mononucleotide (NMN) now and then for spurts, but is not currently taking it, though he plans to go back on it in February or March.
- Suggests considering Nicotinamide mononucleotide (NMN) as it has more promising research, even if still in animal models, compared to Resveratrol.
Dave Asprey · Betaine · recommends
- Recommends taking betaine HCL (stomach acid) with meals to improve protein absorption, as stomach acid decreases with age.
- Recommends NMN (nicotinamide mononucleotide) as a precursor to NAD+, suggesting clinical research used between 600 and 900 mg a day for measurable increases in NAD levels and improvements in energy and performance.
- Recommends supplementing with NMN (nicotinamide mononucleotide) to raise NAD+ levels and keep the cleanup machinery running smoothly.
- Dave Asprey recommends NMN (nicotinamide mononucleotide) as a precursor to NAD+, noting it converts one step faster and tends to provide more immediate noticeable results, with clinical research using between 600 and 900 mg daily.
- Recommends supplementing with NMN (nicotinamide mononucleotide) to raise NAD+ levels and keep the cleanup machinery running smoothly, especially when other signals are in place.
- Takes stomach acid, betaine HCL, and enzymes to help digest food, which he says speeds healing and resilience.
- States that if you take Pepsid, you have to take betaine and enzymes to counteract the digestion-ruining effects, and also suggests taking a little betaine with a meal to help with nutrient absorption.
- Recommends always taking Betaine HCL, which is stomach acid, with food when taking Pepcid AC for long COVID protocols, as it's necessary for the Pepcid to work effectively.
- Recommends taking betaine HCL religiously with every meal during protocols that block histamine response to prevent gut problems from lack of stomach acid.
- Increased his Betaine HCL intake to address low stomach acid, which he believes is necessary when eating a lot of steak.
- Recommends taking Betaine HCL to increase stomach acid if on a med, to help with delayed gastric emptying.
- Advises taking Betaine HCl because Pepcid, which he recommends, blocks stomach acid.
- Mentions NMN as a nicotinamide mononucleotide and NAD precursor, noting it's no longer available over the counter in the U.S. due to pharmaceutical interventions.
- Takes nicotinamide mononucleotide, along with niacin, actual NAD, and True Niagen.
Dr. Mark Hyman · Betaine · uses
- Uses Betaine HCl to provide stomach acid, which helps digest food and reduce SIBO.
- Suggests that betaine hydrochloride can be used to acidify the digestive system, helping to relieve digestive problems associated with chronic pancreatic insufficiency.
- Recommends betaine, found in beets, quinoa, spinach, and regeneratively raised beef and turkey, for supporting methylation.
- Recommends Betaine HCL to increase stomach acid and help with food digestion.
- Recommends replacing digestive enzymes or things like betaine HCl to help the body digest food and break down proteins, especially when the gut is inflamed, though they may not be needed once the gut has healed.
- Uses betaine HCl to support stomach acid in patients.
- Uses betaine in their clinic to address issues with protein digestion, particularly for individuals with a lack of stomach acid, after measuring their acid levels.
- Uses nicotinamide mononucleotide (NMN) as one of his favorite forms of niacin for mitochondrial function.
- Explains that methylation is regulated by important molecules like B6, B12, folate, betaine, and methionine, which are found in our diet.
- Uses Betaine HCl to increase stomach acid and help the body digest food more effectively.
- Takes NMN (nicotinamide mononucleotide), a precursor to NAD, to theoretically increase NAD levels in his cells and keep his sirtuins and epigenome properly regulated for longevity.
- States that NMN, or nicotinamide mononucleotide, is an NAD booster used in his lab, which cells convert into NAD, leading to a spike in NAD and phenomenal effects on the body's protective mechanisms.
- States he uses nicotinamide mononucleotide (NMN) and finds it helpful for mitochondrial function.
- Recommends Betaine HCl to increase stomach acid, which helps the body digest food and makes it easier to absorb nutrients, reducing the likelihood of feeding dysbiotic bacteria.
Dr. Rhonda Patrick · Betaine · neutral
- Mentions betaine or trimethylglycine as something that may improve power output during exercise.
- Mentions nicotinamide mononucleotide as an NAD booster, but notes that the data for such boosters is mostly from animal studies and their long-term human effectiveness and safety are still unknown.
- Explains that NMN (nicotinamide mononucleotide) is the immediate precursor to NAD and is converted to NAD within one step in the cell.
- Is currently not supplementing with nicotinamide mononucleotide (NMN).
- Rhonda Patrick mentions that nicotinamide mononucleotide delayed aging in animal models.
Ben Greenfield · Betaine · recommends
- Recommends taking trimethylglycine, also known as betaine, beforehand with NAD IVs to stave off gastric distress and sympathetic nervous system stimulation.
- Warns that taking high-dose NR or NMN can lead to a buildup of nicotinamide and a methylation problem, and that studies show increasing the dose of NR beyond a certain point does not increase NAD+ levels but does increase methyl nicotinamide.
- States that Nicotinamide Adenine Dinucleotide (NAD+) status is one of the "biggest" smallest molecules to consider for performance, longevity, and well-being, highlighting its paramount necessity to mitochondrial function, energy production, and aging.
- Believes there is merit in molecules like Vitamin B3, nicotinamide riboside, or NMN, which are known biogenesis boosters.
- Recommends betaine hydrochloride, three a day, one per meal, to help with digestion and nutrient absorption.
- Notes that combining blood flow restriction with a blood flow precursor like betaine results in significantly greater training benefits.
- Recommends Thorne ResveraCel as a good source of resveratrol, noting it combines resveratrol with nicotinamide riboside, quercetin, and betaine to support cellular function and methylation, which are affected by EMF.
- Recommends Thorne ResveraCel, which contains Resveratrol, quercetin, and betaine, for anti-aging and to combat free radicals that cause eye damage or glaucoma.
- Lists Betaine HCl digestive enzyme as a resource from the episode.
- Recommends supplementing with Betaine HCl with a protein-based meal to help break down protein, especially if one has an underactive stomach and is not producing enough stomach acid. He personally takes 8 capsules before heavy protein meals.
- Ben discusses Betaine HCL in the context of a listener experiencing insomnia, anxiety, and joint pain from it, and considers if it could be related to suppression of potassium and magnesium.
- Lists Betaine Hydrochloride supplements as a resource for healing the gut.
- Ben mentions Betaine HCL as a resource for caloric needs after an endurance event.
- Uses 10 mg of Nicotinamide Mononucleotide from Troscriptions in the morning for cognitive enhancement.
Siim Land · Betaine · recommends
- Recommends getting trimethylglycine (TMG), also known as betaine, from whole foods like beetroot, shrimps, spinach, wheat germ, wheat bran, mushrooms, and various vegetables to support DNA methylation.
- Used to take NMN to increase NAD levels and slow down aging, but now prefers Nicotinamide.
- Mentions nicotinamide mononucleotide (NMN) as a potential cheaper energy supplement if he wanted to increase energy levels.
- Is currently taking NMN, either 250 or 500 milligrams, experimenting with it alongside Nicotinamide Riboside.
- Mentions that Nicotinamide Mononucleotide (NMN) is getting pulled from the market because it's being turned into a drug, which they find absurd.
- Recommends TMG (trimethylglycine or betaine) for longevity and DNA methylation, especially for poor methylators who might need up to 2000-3000 milligrams per day, while those with good methylation genes might not need to supplement if they eat TMG-rich foods.
- States that betaine, or trimethylglycine, has been shown to decrease plasma homocysteine levels, with supplementation of at least 4 grams a day for a minimum of six weeks being effective.
Andrew Huberman · Betaine · neutral
- Discusses betaine as a potential alternative for creatine non-responders, taken at 1 to 3 grams per day, which helps with amino acid synthesis and energy shunting.
- Mentions that there is some evidence that betaine, also called trimethylglycine, can improve lean mass and power output.
- Notes that many people who have difficulty adjusting their gut pH and microbiota have benefited from taking betaine HCL pepsin tablets or capsules during meals, starting with one or two and experimenting to find a comfortable level.
- Andrew Huberman recommends betaine for creatine non-responders, suggesting a dose of one to three grams per day to help with amino acid synthesis and shunting of energy.
- Huberman discusses betaine as a potential supplement for creatine non-responders or if homocysteine is persistently elevated, with a typical dosage of 1 to 3 grams per day.
Peter Attia · Nicotinamide Mononucleotide · stopped
- Stopped taking NMN after seeing his homocysteine level go up to 15 from a typical 7, which he believes was a reflection of the pathway where NMN is cleaved by CD38, increasing nicotinamide and its methylation, potentially depleting the one-carbon cycle.
- Discusses nicotinamide mononucleotide (NMN) as an NAD precursor that has been shown in some studies to lead to benefits associated with healthy aging and lifespan extension in mice, though these results are not always reproducible.
- States that oral Nicotinamide Mononucleotide is likely not absorbed intact because it has a charged phosphate group that generally cannot cross cells.
- Discusses a study where a high dose of nicotinamide mononucleotide (NMN) was tested in overweight or obese postmenopausal pre-diabetic women, finding improved muscle insulin sensitivity.
Bryan Johnson · Nicotinamide Mononucleotide · uses
- Takes 500 mg of NMN (Nicotinamide Mononucleotide) in the morning.
RAL Summary
Members OnlyTier 3 for Immune Health
This product is placed in the reviews tier because 90% of its 3793 ratings are positive, while human studies are thin. The main nicotinamide mononucleotide trial found no immune benefit over placebo [1], and betaine is present only in a trace amount compared with the 2 grams studied [4].
- Betaine: trace amount
Where the evidence disagrees: 3 of the 12 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Immune system, Blood
Combine with: Not compulsory.
Possible side effects: In the studies, nicotinamide mononucleotide was well tolerated at doses up to 2 grams a day for 2 weeks. No major side effects were reported for betaine.
Supplement Facts
NMN 207.5 mg · Betaine Anhydrous 42.5 mg
| NMN (Beta-Nicotinamide Mononucleotide) | 207.5 mg | † |
| Betaine Anhydrous (Trimethylglycine) | 42.5 mg | † |
Directions: Take 1 capsule daily with 8 ounces of water or your favorite beverage. May be taken with or without food.
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Graded October 23, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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