DNA Anabolics Neanderthal Pro-Tren Stack Review

Neanderthal Pro-Tren Stack is a discontinued oral "prohormone" capsule product from DNA Anabolics. Stack3d's brand introduction lists it in the muscle-building range, described as a "pro-tren stack." That range sat alongside Primordial, Cro-Magnon, Max Test and PCT products. It is not a conventional dietary supplement. It belongs to the designer prohormone category, which was marketed to people trying to gain lean mass and lose fat at the same time. The only formula detail I found came from a forum poster, not an official label. The poster described 15mg of epi, 20mg of tren, 100mg of hexadrone and 100mg of DHB per serving. The "tren" component is most likely a trenbolone-related precursor. That is my inference, and I could not verify the exact compounds. A separate database listing shows the product with 4 ingredients, including 6,7-dihydroxybergamottin. That compound is a grapefruit-derived CYP3A4 inhibitor. It is typically included to slow liver metabolism of the other actives and raise their bioavailability. How it is meant to work: - **Conversion to active meds.** Prohormones are designed to be converted by enzymes in the body into active anabolic-androgenic meds. Trenbolone-type compounds bind strongly to the androgen receptor. Trenbolone is classed as an androgen and anabolic a med, and it is a controlled substance in the US (Schedule III). - **Anabolic signalling.** Androgen-receptor activation in muscle is intended to increase protein synthesis, nitrogen retention and anti-catabolic effects. - **Methylated, oral-active compounds.** Hexadrone-type and epi-type compounds are alkylated so they survive first-pass liver metabolism. This is also why such products are associated with liver strain. - **Metabolic inhibition.** The bergamottin-type ingredient is meant to prolong exposure to the other compounds. Practical cautions: products of this type are associated with suppressed natural testosterone, liver stress, lipid changes and hormonal side effects, and they are often banned in sport. The original stack appears to be off the market. DNA Anabolics later sold "Neanderthal II," a SARM triple stack of ostarine, S4 and GW1516, which is a different formula. Anyone considering a product like this should talk to a physician first.