Doctor Gilmore Meta-Seven Review
Product Focus: Occasional Heartburn: Fast ReliefAlso covers:Digestion
Tier ⓘ
Tier 4 · Rank 18
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 18 within Tier 4 for Occasional Heartburn: Fast Relief; 27 of 28 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
15 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Biohacker Mentions
0 of 10
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Study, Trial or Testing Result Summary
Members Only47 human studies · 31 improved
47 human studies31 improved14 no effect373,521 people studied
No study tested this product, and none tested any of its ingredients alone for fast relief of occasional heartburn. Vitamin B12 is at a full dose. In a small study without a comparison group, people with a stomach infection and low B12 who took 1000 micrograms daily for 3 months had faster stomach emptying and less indigestion [1]. A trial in people with acid reflux found a mix containing B12, vitamin B6 and melatonin relieved symptoms after 40 days, but the effect of each vitamin cannot be separated out [2]. Magnesium is below the studied dose here. It mostly helped as part of antacid mixtures, which raised stomach acid levels within minutes [3][4] and eased heartburn in pregnancy [5][6]. One trial found no benefit over a dummy pill [7]. Diet studies of vitamin B6 and reflux disagree [8][9]. Vitamin D was not linked to reflux or indigestion [10][11]. Chromium, alpha lipoic acid and coenzyme Q10 have no human studies for this goal. Animal and cell studies are never counted.
See all 47 studies →Hide the studies
- In a review of nine small trials in pregnant women, drug treatments including a magnesium-aluminium antacid with simethicone gave complete heartburn relief more often than placebo or no treatment, though evidence was limited.Interventions for heartburn in pregnancy.
- A review of nutrition trials in children with cerebral palsy found magnesium helped constipation but did not assess heartburn relief.Dietary and nutritional interventions in children with cerebral palsy: A systematic literature review.
- In 351 adults with acid reflux disease, a blend containing vitamin B6 plus melatonin and other nutrients led to complete symptom relief in all 176 people after 40 days, versus 65.7% of those taking a med, though the vitamin B6 effect cannot be separated from the other ingredients.Read the study on PubMed (16948779) →
- In 276 adults with indigestion, one month of a simethicone, charcoal and magnesium oxide combination lowered overall symptoms and epigastric burning more than placebo.Efficacy of a simethicone, activated charcoal and magnesium oxide combination (Carbosymag®) in functional dyspepsia: res…
- In 100 pregnant women with heartburn, a magnesium-aluminium antacid gel for two weeks worked about as well as an alginate-based product, with 88% improving in heartburn frequency versus 80%.Efficacy of alginate-based reflux suppressant and magnesium-aluminium antacid gel for treatment of heartburn in pregnanc…
- In 97 patients with gastritis, esophagitis or upper abdominal complaints, a magnesium and aluminium hydroxide antacid with smectite beat an aluminium hydroxide antacid on pain relief, speed of effect and heartburn over four weeks.[Antacid therapy of upper abdominal symptoms. Double-blind study on the effect and tolerance of 2 antacids in gastritis …
- In 90 people with acid reflux disease, adding magnesium-containing mineral water to standard treatment for a month improved indigestion and pain more than standard treatment alone.Application of mineral waters in the complex treatment of patients with gastroesophageal reflux disease.
- In 89 people with nonulcer indigestion, four weeks of an aluminum-magnesium antacid did not relieve symptoms compared with placebo.Antacids reduce Campylobacter pylori colonization without healing the gastritis in patients with nonulcer dyspepsia and …
- In 89 people with reflux not helped by standard drugs, a regimen including magnesium aluminum carbonate gave the best improvement in heartburn sensation compared with a herbal decoction.Efficacy evaluation and exploratory analysis of influencing factors of Banxia Houpu Decoction in the treatment of refrac…
- In 80 children with reflux, 8 weeks of domperidone plus magnesium and aluminum hydroxide fully cleared symptoms in 16 of 20 children, versus 7 of 20 on placebo.Domperidone plus magnesium hydroxide and aluminum hydroxide: a valid therapy in children with gastroesophageal reflux. A…
- In 72 infants with regurgitation, two weeks of magnesium alginate lowered reflux symptom scores about as well as thickened formula, at slightly lower cost.Magnesium Alginate in Gastro-Esophageal Reflux: A Randomized Multicenter Cross-Over Study in Infants.
- In 64 infants with reflux, magnesium alginate plus simethicone reduced symptom scores more than thickened formula or reassurance alone over up to 2 months.Effect of magnesium alginate plus simethicone on gastroesophageal reflux in infants.
- In 50 adults with throat reflux, 2 months of magnesium alginate suspension reduced symptoms and signs about as much as a med 20 mg daily.Read the study on PubMed (35032204) →
- In 49 adults with constipation-type irritable bowel syndrome, a drink with 2 mg vitamin B6, inulin and menthol taken for 2 weeks improved bowel symptoms but caused noticeable heartburn in 10 of 25 people who drank it.[Using a multicomponent functional food in IBS patients with constipation a comparative controlled study].
- In 44 people with reflux, 23 percent reported good relief on a magnesium-aluminium antacid gel over two 15-day periods, compared with 84 percent on Liquid Gaviscon.A comparative crossover study on the treatment of heartburn and epigastric pain: Liquid Gaviscon and a magnesium--alumin…
- In 37 people with chronic dyspepsia, an aluminium-magnesium antacid plus antispasmodic tablet relieved heartburn earlier and more than aluminium hydroxide alone over 4 weeks.A comparison of an antacid plus antispasmodic combination and aluminium hydroxide in dyspepsia.
- In 30 patients with stomach or duodenal ulcers, antacids containing 1.6 g magnesium hydroxide and 1.6 g aluminium hydroxide daily relieved heartburn and pain, but less than when triletide was added.Controlled clinical assessment of the efficacy and tolerance of triletide versus antacids in patients with gastric and d…
- In 24 healthy volunteers, a single dose of Riopan Gel (800 mg magaldrate) or Rennie tablets raised stomach pH for a short time compared with no drug, with Riopan acting faster in the first 5 minutes.Comparison of two antacid preparations on intragastric acidity--a two-centre open randomised cross-over placebo-controll…
- In 20 adults with chronic cough, the antacid Maalox reduced cough-like efforts triggered by deep lung emptying within minutes, while placebo did not, though this study measured cough rather than heartburn.Effect of an anti-reflux medical device in the control of deflation cough: A placebo-controlled comparative study with a…
- In 16 healthy fasting adults, a single 1360 mg dose of the calcium-magnesium antacid Rennie raised stomach acid pH above 3 within about 6 minutes, compared with about 240 minutes with placebo.Comparison of the effect of the antacid Rennie versus low-dose H2-receptor antagonists (ranitidine, famotidine) on intra…
- In 15 patients with reflux-related eye symptoms, a month of magnesium alginate eye drops and tablets brought tear film measures back to normal values.Ocular Surface Disease as Extraesophageal Gastroesophageal Reflux Disease Manifestation: A Specific Therapeutic Strategy…
- In people with reflux oesophagitis over 10 weeks, Gastrocote reduced heartburn days from baseline, though acid exposure was no lower than with cimetidine and the combination with cimetidine worked best.Combined cimetidine-alginate antacid therapy versus single agent treatment for reflux oesophagitis: results of prospecti…
- A single 1.5 gram dose of the aluminium-magnesium antacid almagate was effective for reflux damage to the food pipe in a double-blind crossover trial, with both tested formulations performing equally.Effectiveness of almagate in gastroesophageal reflux disease: a post-hoc analysis of a randomized cross-over double-blin…
- In infants under one year with reflux, giving a small formula feeding before a standard magnesium-aluminum antacid dose improved how well the antacid buffered stomach acid.Antacid and formula effects on gastric acidity in infants with gastroesophageal reflux.
- In 169 people with heartburn, the aluminum-magnesium antacid almagate was effective, and most patients were symptom free by the end of a 2-week open trial with no control group.Treatment of gastric pyrosis with almagate in patients with and without endoscopically demonstrable duodenal ulcer. A mu…
- In 61 adults with fatty liver disease and stomach or bowel symptoms, drinking 400 mL of a magnesium-containing mineral water daily for six months improved lower bowel symptoms, which worsened after stopping; the study had no placebo group and did not test heartburn directly.The use of bicarbonate-sulphate-calcium-magnesium and sodium-low drinkable water improves functional gastrointestinal sy…
- In 60 elderly patients with reflux, an alginate product (Geviskon) relieved heartburn, regurgitation, cough and sore throat more completely and faster than an aluminum-magnesium antacid over 7 days.[Using gaviscon preparation for relief of esophageal, extraesophageal syndromes and functional dyspepsia in elderly pati…
- In 49 healthy adults, a combined esomeprazole and magnesium hydroxide tablet raised stomach pH to 4 faster than enteric-coated esomeprazole alone over seven days of dosing.Pharmacokinetics and Pharmacodynamics of a Fixed-Dose Combination of Esomeprazole and Magnesium Hydroxide Compared to th…
- In a large cohort of about 356,000 people, harder tap water was linked to lower risk of some digestive conditions such as dyspepsia, but moderately hard water was linked to higher risk of reflux disease and peptic ulcer.Water hardness and digestive diseases: a large-scale population-based prospective cohort study.
- In a study of 11,690 people who had endoscopy and diet records, higher dietary vitamin B6 intake was linked to lower odds of non-erosive reflux disease, though this does not prove cause.Gender-specific Effect of Micronutrient on Non-erosive Reflux Disease and Erosive Esophagitis.
- In a case-control study of 890 people, higher dietary vitamin D intake was linked to greater esophageal adenocarcinoma risk but was unrelated to reflux esophagitis.Vitamin D, calcium and dairy intake, and risk of oesophageal adenocarcinoma and its precursor conditions.
- In 605 men, low vitamin D levels were not associated with reflux symptoms or erosive esophagitis, though a trend toward an inverse link with Barrett's esophagus was seen.Association of Vitamin D and Parathyroid Hormone With Barrett's Esophagus.
- In a case-control study of 150 women with reflux and 300 controls in Iran, higher dietary vitamin B6 intake was linked to higher odds of reflux disease.Dietary Vitamin B6 Intake and Gastroesophageal Reflux Disease: A Case-Control Study.
- In a questionnaire survey of 382 Romanian adults with anemia, vitamin D3 was reported to help reduce treatment side effects, which included heartburn, but the survey did not give dose, duration, or percentages.Impact of Side Effects on Anemia Therapy Compliance.
- In a cross-sectional study of 328 young adults, lower dietary vitamin B6 intake was linked to higher overall gastrointestinal symptom scores, but vitamin B6 intake was not directly linked to reflux status.Health cooking at home: can cooking skills reduce gastrointestinal symptoms, cross sectional study?
- In a case-control study of 150 functional dyspepsia patients and 150 controls, low vitamin D was more common in patients, but no vitamin D supplement was tested, so the study does not show that vitamin D relieves symptoms.Association of vitamin D and functional dyspepsia: a case-control study.
- In 100 outpatients with throat reflux, two months of magnesium alginate significantly reduced voice problems, swallowing trouble and cough on a visual scale, with no side effects reported.Magnesium alginate in patients with laryngopharyngeal reflux.
- Children with reflux or eosinophilic esophagitis had normal vitamin D levels (30 ng/mL in both groups), and the study did not test vitamin D supplements against heartburn.Nutritional State and Feeding Behaviors of Children With Eosinophilic Esophagitis and Gastroesophageal Reflux Disease.
- In patients with reflux, Barrett's esophagus, or esophageal adenocarcinoma, vitamin D gene variants were linked to disease progression, but no supplement effect on heartburn was measured.Polymorphisms of Genes Related to Function and Metabolism of Vitamin D in Esophageal Adenocarcinoma.
- A genetic analysis of about 190,000 people per condition found no causal link between vitamin D and functional dyspepsia, while higher genetically predicted vitamin D was linked to lower irritable bowel syndrome risk.Causal associations of 25-hydroxyvitamin D with functional gastrointestinal disorders: a two-sample Mendelian randomizat…
- In 34 people with Helicobacter pylori infection and low vitamin B12, 1000 mcg daily for 3 months shortened stomach emptying time and reduced dyspepsia scores, with no control group.The impact of B(12) treatment on gastric emptying time in patients with Helicobacter pylori infection.
- In 15 children with reflux treated with magnesium and aluminium hydroxide for eight weeks, 12 were cured and 3 improved, and acid reflux measured on pH monitoring was significantly reduced.[Magnesium hydroxide and aluminum hydroxide in the treatment of gastroesophageal reflux].
- Drinking a magnesium-rich sulphate mineral water was linked to fewer symptoms and better heart measures in people with mild gastroesophageal reflux and heart-related symptoms.[Magnesium-containing mineral waters in the treatment of patients with cardial manifestations of gastroesophageal reflux…
- In a lab and small test in normal people, acidic stomach contents helped an alginate and magnesium antacid mixture form a protective floating barrier against reflux, while plain water did not.Use of 111In-labeled alginate to study the pH dependence of alginic acid anti-esophageal reflux barrier.
- A 1994 Ukrainian report describes an antacid containing alginic acid and magnesium, used with antisecretory drugs for dyspepsia and reflux, that forms a protective floating layer in the stomach, but the abstract gives no patient numbers or outcome figures.[The use of 3rd-generation antacid preparations for the treatment of patients with nonulcerous dyspepsia and peptic ulce…
- In 70 rats with surgically induced acute reflux esophagitis, vitamin D3 at low and high doses lowered inflammatory signals in the esophagus, but it did not help in chronic injury and did not improve visible tissue damage; this was an animal study, not a human trial.Elevated Pro-inflammatory Cytokine Levels in Acute Reflux Esophagitis Are Reduced by 1,25 Dihydroxy Vitamin D3.
- In a rat model of reflux damage to the esophagus, vitamin D3 given at 1250 IU per day reduced inflammation and restored heart rate balance, with earlier (preventive) dosing working better than dosing after injury; this was an animal study, not a human trial.Vitamin D3 ameliorates inflammation and autonomic dysfunction in a rat model of reflux esophagitis via modulation of IL-…
Review Totals and Summary
Members OnlyWhat buyers say
Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.
Biohacker Summary
Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it
Magnesium is the main ingredient, and most of the panel recommends or uses it: five recommend it, four use it, and one stays neutral. Sleep is the main reason, with several taking it at night, and a few take 400 mg of magnesium threonate before bed. Glycinate is the other favored form, praised for strong absorption, while threonate is picked for sleep, and one panelist advises 300 to 400 mg daily from food and supplements. Others take it for muscle recovery, cramps, energy, and keeping potassium in the body, and some get it from electrolyte drinks, while one notes it does not fix waking up during the night. Vitamin D is a smaller ingredient in this product, and those who mention it favor D3 taken in the morning, ideally with some fat.
See all 10 biohackers →Hide the biohackers
Dr. Rhonda Patrick · Magnesium · recommends
- Explains that magnesium helps the body activate and metabolize vitamin D, and that magnesium intake has been associated with lower odds of vitamin D deficiency and insufficiency.
- Notes that vitamin D from sunlight, food, or supplements needs to undergo conversions in the liver and kidneys to become its active hormone form, calcitriol.
- Mentions that getting too little magnesium may play a role in declining testosterone levels.
- States that Vitamin D supplementation has been associated with a 40% lower dementia risk, and low levels are linked to a 50 to 80% higher risk.
- Recommends getting enough magnesium, around 300–400 mg daily from diet and supplements, as it is an essential cofactor for vitamin D metabolism. Magnesium glycinate is a good form.
- Mentions magnesium as one of the micronutrients found in multivitamins that people often don't get enough of from their diets.
- Explains that magnesium helps control blood pressure by boosting the production of substances that relax blood vessels and improve cardiovascular health, citing a meta-analysis that found magnesium supplementation at an average dose of 368 mg per day notably lowers both systolic and diastolic blood pressure.
- Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
- Recommends getting adequate vitamin D, noting that people taking vitamin D supplements have a 40% lower risk of dementia, while those with lower vitamin D have a 50-80% higher risk.
- Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
- Vitamin D supplementation was linked to a 40% lower risk of dementia in an observational study of more than 12,000 older adults.
- Mentions that vitamin D also plays a role in maintaining muscle mass.
- Mentions magnesium as an important nutrient component for testosterone.
- Warns that some supplement companies mislead consumers by listing the total compound weight of magnesium citrate as the elemental magnesium dose, when the actual elemental magnesium content is much lower, potentially around 44-66 milligrams.
Dr. Eric Berg · Magnesium · recommends
- Recommends Magnesium glycinate, noting its high absorption rate compared to magnesium oxide, and its support for energy, sleep, muscle relaxation, and vitamin D function.
- Lists Vitamin D as an ingredient found in sardines.
- Mentions that one can of sardines provides 348% of the daily Vitamin B12.
- Dr. Berg states that when nutrients like magnesium are too low, fatigue and weakness can follow.
- Recommends Vitamin D3 because it's nearly impossible to get enough from food and most people don't get enough sun, advising to aim for blood levels of at least 50 to 80 ng/mL.
- Dr. Berg states that when nutrients like vitamin D are too low, fatigue and weakness can follow.
- Dr. Berg states that when nutrients like vitamin B12 are too low, fatigue and weakness can follow.
- Recommends focusing on magnesium to support stronger bones if a neck hump is associated with osteoporosis.
- Explains that leg and calf cramps are most often caused by low magnesium, with leafy greens being a top source.
- States that magnesium is a cofactor that allows B1 to work more efficiently.
- Recommends focusing on vitamin D3 to support stronger bones if a neck hump is associated with osteoporosis.
- Recommends a minimum of 10,000 IU of vitamin D per day to support natural killer cells.
- Recommends coenzyme Q10 at 200 mg a day to support energy.
- Suggests that increasing vitamin D3 may help address the underlying problem of bruxism.
Thomas DeLauer · Magnesium · recommends
- Recommends taking magnesium glycinate and threonate at night to act as a brake on the nervous system, block excitatory signaling, help wind down, and support serotonin and melatonin production for better sleep.
- Recommends taking Vitamin D3 in the morning, between 6:00 and 10:00 a.m., to align with the body's natural metabolic activation phase and sunlight-triggered vitamin D production.
- Mentions that magnesium glycinate also helps a lot with sleep.
- Mentions that restless leg syndrome is often treated with magnesium, but states that the sensation is actually coming from three other issues.
- Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
- Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
- Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
- Uses vitamin D3 in the fall and winter months when getting less sun, as it's important to supplement it then.
- Recommends taking a massive amount of vitamin D simultaneously with an early morning massive breakfast to help reset circadian rhythms and address hyperphagia.
- Recommends Vitamin B12 for mental health and mood, explaining its role in myelination and neurotransmitter production. They specifically recommend a liposomal and micellar form of methylcobalamin B12 for better absorption and to avoid toxicity.
- Recommends magnesium, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
- Recommends Vitamin D, stating that it has receptors throughout the brain and deficiency can quickly impact brain and mood.
- Notes that modern agricultural practices have led to soils depleted of trace minerals like magnesium, resulting in widespread magnesium deficiency.
- Takes supplemental vitamin D because he is skin sensitive and from northern latitudes, limiting his UV exposure.
Andrew Huberman · Magnesium · recommends
- Notes that Les Spellman's team includes 'Magnesium timed right' as part of their game plan to optimize recovery in unfavorable conditions.
- Discusses Magnesium Threonate as a tool for falling asleep.
- Notes that most people are probably deficient in vitamin D and benefit from supplementing, but there's no point in doing it unless you're deficient for most things.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 5,000 IU of Vitamin D3 in the morning for longevity.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Confirms that magnesium is absolutely important for cognitive function, noting studies show those with lower magnesium intakes tend to perform less well on cognitive function tests, and it's related to brain changes over time and dementia risk.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- States that Vitamin D is one of the critical nutrients with the best evidence for cognitive function and reducing the risk of dementia.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 5000 IU of Vitamin D3 in the morning.
- He takes 400 mg of Magnesium L-Threonate from Double Wood before bed for sleep.
- He takes 5,000 IU of Vitamin D3 in the morning for overall health.
Dr. Mark Hyman · Magnesium · recommends
- Recommends magnesium breakthrough advanced ten from Biooptimizers, which is their most complete magnesium formula with 10 bioavailable forms and 550 milligrams of elemental magnesium, designed to support restful restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Consumes Zetopia's Atlantic salmon to get Vitamin D, particularly in the winter months, as it is one of the few foods that provides both Omega-3s and Vitamin D.
- Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
- Explains that a lack of magnesium can cause muscles and nerves to malfunction, resulting in muscle weakness, twitching, and cramps.
- Mentions that the body makes vitamin D from sunlight exposure, and a deficiency can hinder calcium absorption, which is crucial for strong bones.
- Recommends Vitamin D for health, stating that amazing things happen when patients' vitamin D statuses reach optimal levels.
- Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
- Mentions vitamin D as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
- Notes that vitamin D plays a role in immune function.
- Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
- Recommends magnesium as a basic supplement during detoxification to support pathways, help with constipation, and provide electrolytes.
- Recommends checking vitamin D levels and states that if they had to pick one single intervention for immune health, vitamin D would be it.
- Recommends Magnesium Breakthrough Advanced 10 from Biooptimizers, which contains 10 bioavailable forms and 550 mg of elemental magnesium, to support restful sleep, restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Dr. Hyman discusses vitamin D in relation to sun exposure patterns.
Dave Asprey · Magnesium · uses
- Looks at magnesium alongside protein to keep muscle for the long run.
- Suggests adding magnesium to help keep potassium in the system longer, as they work hand in hand.
- Takes Vitamin DAKE from Suppgrade Labs.
- Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
- Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
- Suggests that vitamin D supports brain health, muscle function, and focus.
- States that magnesium can affect how the body responds to a supplement.
- Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense for male fertility, even though supplementation did not improve overall semen parameters in a randomized trial.
- States that currently, he is only taking vitamin C and vitamin D.
- Recommends fixing sleep with 300mg of Magnesium 101 before bed if diet and exercise aren't melting stubborn belly fat.
- Dave Asprey says his daily routine includes magnesium as part of a carefully developed combination for longevity.
- Recommends magnesium glycinate for sleep, stating that trials show it helps people fall asleep about 17 minutes faster and that he finds it incredibly effective.
- Recommends vitamin D, noting it's actually a hormone and that most people are deficient, even those who take it, because they don't take enough.
- Mentions magnesium glycinate as one of the five gut-friendly, extensively researched ingredients in Kill Switch that helps with natural sleep.
Ben Greenfield · Magnesium · uses
- Uses magnesium during surgery because it is neuroprotective.
- Notes that Vitamin D is actually a hormone and recommends patients aim for levels around 40 to 50, or even 60 for fracture healing, for optimal healing, as opposed to just above 20 which is considered normal.
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Mentions magnesium as part of a bare-minimum protocol.
- Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
- Mentions vitamin D as part of a bare-minimum protocol.
- Advises getting vitamin D levels between 60 and 100 nanograms per milliliter as a minimum step for overall health and to slow down heart disease.
- Mentions chromium as a secondary ingredient in blood sugar control products, along with vanadium and bittermelon extract.
- Recommends supplementing with magnesium threonate if one is low in magnesium, as it crosses the blood-brain barrier and is demonstrated to increase hippocampus plasticity, theoretically making one smarter and improving memories.
- Uses Magnesium Breakthrough from BIOptimizers as part of their daily stack, taking four capsules in the evening to support relaxation, recovery, and a good night of sleep.
- Has been taking Vitamin D3 K2 for over a decade.
- Recommends Celtic Sea Salt's new electrolyte drink "Hydrate" for replacing electrolytes and trace minerals lost through sweat, noting it contains 70 naturally occurring trace minerals, plus magnesium, taurine, and potassium.
- Had heart palpitations when he was really overdoing magnesium, not knowing what he was taking.
- Recommends taking magnesium as a co-factor to increase vitamin D absorption.
Siim Land · Magnesium · recommends
- States that Magnesium can be a useful addition for some people for sleep.
- Advises against taking vitamin D in the morning with other supplements because it is fat soluble and requires dietary fat for better absorption.
- Recommends taking Vitamin D with fat for better absorption.
- States that Vitamin D connects biology to light and that UVB reaching the skin enables its production.
- Recommends magnesium for sleep, especially deep sleep, and suggests trying better types like Threonate, Biscinate, or Torate, referencing a study where magnesium supplementation improved deep sleep.
- Recommends Magnesium for blood pressure, migraines and deficiency, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Magnesium as one of 15 supplements backed by human studies.
- States that magnesium is a fundamental mineral governing over 600 enzymes and metabolic reactions, and recommends that most people need at least 400-500 mg/d for health, with some needing up to 600 mg/d.
- Lists seafood and pumpkin seeds as sources of Magnesium.
- Thinks magnesium has some of the strongest evidence and is worth considering.
- Thinks vitamin D has some of the strongest evidence and is worth considering.
- Notes that Vitamin K2 pairs well with vitamin D by regulating calcium and bone mineralization.
- Recommends taking vitamin D supplements with some fat to maximize its absorption, suggesting with food or a teaspoon of olive oil.
- Notes that taking vitamin D3 with a fat-containing meal resulted in 32% higher peak blood vitamin D levels.
Bryan Johnson · Magnesium · uses
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Mentions that the sunlight assessment claims low vitamin D levels cause the immune system to misfire, and notes that their vitamin D has been measured.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 5000 IU of Vitamin D3 in the morning for longevity.
- He takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- He takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 5,000 IU of Vitamin D3 in the morning for longevity.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
Peter Attia · Magnesium · neutral
- Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Lists vitamin D as one of her staple supplements.
- Notes that several studies show patients taking vitamin D can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
- Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
- States that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin D for both sexes.
- Uses vitamin D as an example of how people might dismiss its efficacy due to failed clinical trials that didn't adjust the dose or measure levels.
- In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin D for both sexes.
- Suggests that supplementing with lots of vitamin D might help overcome the negative effects of phenytoin on bone health by improving calcium absorption, though he is unaware of studies on this.
- Recommends magnesium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 300 to 500 milligrams as a minimum, and personally aims for about a gram of supplemental magnesium.
- Recommends Vitamin D3 as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 800 to 1,000 IU, which can be obtained through sunlight or supplementation.
- Recommends magnesium for optimizing bone mineral density, suggesting a daily intake of 300 to 500 milligrams as a minimum, but personally aims for about a gram.
- Suggests that supplementing with lots of vitamin D might overcome the negative effects of phenytoin on bone health by counteracting increased catabolism of vitamin D and subsequent decreased calcium absorption.
- Recommends vitamin D for people who tend to be vitamin D deficient, such as those living in Portland, Oregon.
RAL Summary
Members OnlyTier 4 for Occasional Heartburn: Fast Relief
The evidence is thin. The supportive studies tested mixtures of ingredients or had no comparison group, magnesium is below the studied dose, and there are no reviews, so the product stays emerging.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 14 of the 47 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Digestive system
Combine with: Combine with a healthy diet and lifestyle.
Possible side effects: In one trial, a drink containing a small amount of vitamin B6 with other ingredients caused heartburn in 10 of 25 people. No other side effects were reported.
Supplement Facts
Vitamin D3 500 IU · Vitamin B6 25 mg · Vitamin B12 5 mg
Supplement Facts
Serving Size 1 Capsule(s)
Servings Per Container 90
Amount Per Serving% Daily Value
| Vitamin D3 | 500 IU | |
| Vitamin B6 | 25 mg | |
| Vitamin B12 | 5 mg | |
| Magnesium | 200 mg | |
| Chromium | 15 mcg | |
| Alpha Lipoic Acid | 100 mg | † |
| Coenzyme Q10 | 50 mg | † |
† Daily Value not established.
Other ingredients: Gelatin, Microcrystalline Cellulose, Rice Flour, Magnesium Stearate.
Directions: Directions: Take one capsule each morning. It should be taken with your daily multivitamin as a part of an overall nutritional program.
Barcode (UPC) 638932867943 · Label source: NIH label database · Report a label change
Other sizes and barcodes: 30 Capsule(s), UPC 0 638932 867950 (not checked yet)
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More occasional heartburn: fast relief products
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Graded November 14, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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