Doctor's Best Milk Thistle 150 mg With ETHIS-094 Review

Product Focus: Gallbladder and Fat DigestionAlso covers:Liver
Tier ⓘ
Tier 3 · Rank 3
Tier 3 · Reviewed. Strong review agreement, with limited or early support from human studies. Rank 3 within Tier 3 for Gallbladder and Fat Digestion; 3 of 9 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
55 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
95% of 456
Biohacker Mentions
0 of 10

Study, Trial or Testing Result Summary

Members Only3 human studies · 2 improved
3 human studies2 improved124 people studied

Milk thistle is the only ingredient, at 300 mg a day when taken as directed at two servings a day. The studies used 420 mg of silymarin, the active part of milk thistle, a day. The human evidence for gallbladder support is limited but points toward a benefit. In a small controlled study of 19 people, some with gallstones and some who had their gallbladder removed, 420 mg daily for 30 days lowered the cholesterol in their bile. It also lowered a score that measures how likely bile is to form stones [1]. In a placebo-controlled trial of 105 adults with sudden liver inflammation, the same daily amount for four weeks cleared yellowing of the skin and eyes and dark urine sooner, and lowered one form of bilirubin, a bile pigment. Liver enzymes and the other form of bilirubin did not change [2]. A mouse study, not in people, found silymarin reduced gallstone formation on a high-fat diet [3]. No study measured fat digestion or comfort after meals directly. Animal and cell studies are never counted.

See all 3 studies →Hide the studies

Review Totals and Summary

Members Only456 reviews · 95% positive
456 reviews · Google Shopping 456
95% positive0% neutral5% negative

Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.

Biohacker Summary

Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it

Six of the ten panelists spoke about milk thistle, the main ingredient, and most of them recommend it, mainly for liver health and detox support. Some also take it around alcohol, before hot-cold contrast therapy, or for allergy symptoms, and one suggested it for skin and prostate concerns. Doses given were 200 to 400 mg of silymarin at 80 percent, 70 to 140 mg of silymarin taken 30 to 60 minutes before contrast therapy, and 200 mg a day for allergy symptoms. It was paired with NAC and vitamin C in a case of accidental poisoning, and one panelist said it works through a similar pathway as NAC. One panelist stopped taking it because it did nothing for him and warned that it can raise liver enzymes in some people, while another stayed neutral, saying he feels good on it for about a week at a time.

See all 6 biohackers →Hide the biohackers
  • Thomas DeLauer · Milk Thistle · neutral
    • 16 Oct 2026 · neutral · YouTube ↗
      Notes that Dose Daily contains organic milk thistle, highlighting its significant data supporting liver health benefits.
    • 5 Sep 2026 · uses · YouTube ↗
      Says he feels really good when he takes milk thistle, usually for about a week, and notes it is effective.
    • 1 Sep 2026 · recommends · Instagram ↗
      Recommends Milk thistle, specifically 200-400mg of silymarin at 80%, for decent reductions in ALT and AST and higher antioxidant enzyme activity.
    • 20 Aug 2026 · recommends · Instagram ↗
      Recommends milk thistle for liver health, explaining that silymarin lowers MDA and raises antioxidant enzymes.
    • 10 Jul 2026 · recommends · YouTube ↗
      Mentions Milk Thistle as an ingredient in DOSE that has proven literature behind it for liver health.
    • 18 Jun 2026 · recommends · Instagram ↗
      Recommends milk thistle for the liver, citing a study where it reduced a marker of liver stress and increased antioxidant defense enzymes.
    • 14 Jun 2026 · uses · YouTube ↗
      Mentions that Dose Daily, which he recommends for liver support, contains organic milk thistle, noting that milk thistle has a lot of data behind it for promoting daily liver function.
    • 10 Jun 2026 · recommends · YouTube ↗
      Recommends milk thistle for liver health, stating it competitively inhibits toxin binding sites on liver cells, decreasing the liver's load, and upregulates glutathione, reducing elevated liver enzymes even in patients with fatty liver disease, but advises cycling it.
    • 6 Apr 2026 · recommends · YouTube ↗
      Recommends milk thistle to help the liver clear things out of the system, including excess cortisol.
    • 18 Mar 2026 · recommends · YouTube ↗
      States that simple things like milk thistle supplementation are quite good for the liver, recommending small amounts.
  • Dr. Eric Berg · Milk Thistle · recommends
    • 20 Sep 2026 · recommends · Facebook ↗
      Recommends taking milk thistle for alcohol and for certain medications.
    • 12 Sep 2026 · recommends · X ↗
      Suggests that small changes like milk thistle can help with deep rest.
    • 30 Aug 2026 · recommends · Facebook ↗
      Dr. Eric Berg recommends taking milk thistle to support the liver and help improve skin problems.
    • 26 Jun 2026 · neutral · YouTube ↗
      Describes milk thistle as an antidote for liver protection against poisons and a powerful antioxidant for nerves and the brain, helping to decrease toxic plaque associated with dementia.
    • 9 Oct 2025 · recommends · YouTube ↗
      Recommends Milk Thistle as a natural inhibitor of the five alpha reductase enzyme, which helps reduce DHT and has very few side effects for an enlarged prostate.
    • 18 Sep 2025 · recommends · YouTube ↗
      Recommends milk thistle as an herb that can increase the contraction of the gallbladder.
    • 31 May 2025 · recommends · YouTube ↗
      Recommends milk thistle as the best antidote for snake bites.
    • 10 Mar 2025 · recommends · Podcast ↗
      Recommends milk thistle before bed if night waking between 1 a.m. and 3 a.m. signifies a liver problem.
    • 3 Mar 2025 · recommends · Podcast ↗
      States that milk thistle is great for detoxification.
    • 28 Oct 2024 · recommends · YouTube ↗
      Recommends milk thistle for anything poisonous to the liver.
  • Dr. Mark Hyman · Milk Thistle · recommends
    • 27 Jul 2026 · recommends · YouTube ↗
      Recommends milk thistle for detoxification support.
    • 18 Oct 2024 · recommends · YouTube ↗
      Recommends taking the herb milk thistle before and after drinking, as it is great for helping liver detoxification.
    • 25 Sep 2024 · recommends · YouTube ↗
      Recommends milk thistle for detoxification, lowering iron, and reducing liver inflammation.
    • 28 Jun 2024 · recommends · YouTube ↗
      Dr. Hyman recommends Milk Thistle.
    • 7 Jun 2024 · recommends · YouTube ↗
      States that milk thistle is great for detoxing.
    • 15 Jan 2024 · recommends · YouTube ↗
      Recommends milk thistle as an incredible herb that helps with liver disease and boosting glutathione.
    • 8 Jan 2024 · recommends · YouTube ↗
      Recommends taking milk thistle to boost glutathione and support detoxification.
    • 9 Jun 2023 · recommends · YouTube ↗
      Recommends milk thistle as an herb that can be used to help boost the body's detox pathways.
    • 7 Oct 2022 · recommends · YouTube ↗
      Recommends milk thistle as a great herb to help heal the liver.
    • 2 Sep 2022 · recommends · YouTube ↗
      Recommends milk thistle as an incredible herb that helps with liver disease and boosting glutathione.
  • Ben Greenfield · Milk Thistle · recommends
    • 3 Apr 2026 · recommends · X ↗
      Recommends taking a milk thistle supplement standardized to 70-140mg silymarin 30-60 minutes before hot-cold contrast therapy.
    • 9 May 2024 · recommends · YouTube ↗
      Mentions milk thistle extract as something that can help accelerate the liver's detox pathways to get rid of acetaldehyde more quickly.
    • 2 Mar 2023 · neutral · YouTube ↗
      Includes milk thistle in the senolytic formula because it mechanistically works on a subfamily of tyrosine kinases, which are important in shifting the balance towards apoptosis, similar to how a med works, and it is also a healthy liver tonic herb.
    • 23 Feb 2023 · uses · YouTube ↗
      States that if they have to use chemicals like heartworm prevention or flea and tick treatments on their dog, they will use milk thistle or a liver detox to support detoxification.
    • 2 Feb 2023 · recommends · YouTube ↗
      Recommends taking milk thistle along with NAC, vitamin C, and water in case of accidental poisoning, stating that this combination could save a life from almost any kind of poison.
    • 4 Jul 2019 · recommends · YouTube ↗
      Recommends milk thistle extract, specifically silymarin, for its ability to protect and promote the growth of liver cells, fight oxidation, block toxins from entering cell membranes, and enhance detoxification by preventing glutathione depletion.
    • 16 May 2019 · uses · YouTube ↗
      Uses Kion's MetaClear SGS meal replacement powder, which is formulated with multivitamins, minerals, and detoxification cofactors to support liver and gut health, and he blends it with ice, coconut milk or bone broth, sea salt, and sometimes olive oil.
    • 6 Dec 2018 · uses · YouTube ↗
      Uses milk thistle as part of his herbal anti-inflammatories for soreness.
    • 6 Oct 2018 · neutral · Podcast ↗
      Mentions Milk Thistle as a nutrient that can help increase the body's own glutathione.
    • 6 Oct 2018 · recommends · YouTube ↗
      Recommends Milk Thistle to enhance GST function, which is important for glutathione recycling, especially for individuals with genetic deletions in GST genes.
  • Siim Land · Milk Thistle · stopped
    • 27 Feb 2026 · stopped · YouTube ↗
      Tried milk thistle for improving liver health based on research, but it didn't do anything for him.
    • 3 Sep 2025 · stopped · YouTube ↗
      Used to take milk thistle in the past but no longer does, as he has already tested most supplements.
    • 25 Jul 2025 · neutral · YouTube ↗
      Mentions milk thistle as something that helps support detox.
    • 4 Apr 2025 · warns · YouTube ↗
      Notes that milk thistle, a famous supplement for fatty liver, can actually raise liver enzymes in some people and does not lower them universally, and that its active ingredient, pselarin, is also found in ground flaxseed, which is a better alternative.
    • 1 Jun 2024 · uses · YouTube ↗
      Siim Land, Inca, started using milk thistle around the same time her liver values improved, noting that it works through a similar pathway as NAC.
    • 4 Oct 2021 · recommends · YouTube ↗
      Includes milk thistle among supplements that can boost autophagy levels.
    • 15 Sep 2021 · uses · YouTube ↗
      Due to a liver problem and high cholesterol, Siim Land takes "quite a bit" of milk thistle.
    • 3 Oct 2020 · recommends · YouTube ↗
      Suggests taking milk thistle to bind to toxins and prevent detox symptoms.
    • 3 Dec 2019 · recommends · YouTube ↗
      Recommends milk thistle as an example of an easy-to-find binder for detox symptoms.
  • Dave Asprey · Milk Thistle · neutral
    • Date not recorded · neutral · Website ↗
      Dave Asprey mentions Milk thistle as a natural remedy for allergy symptoms.
    • Date not recorded · recommends · Website ↗
      Suggests trying milk thistle seed for allergy symptoms, highlighting its anti-inflammatory properties that can block histamine release and support liver detoxing abilities. They recommend starting with 200 mg per day when experiencing symptoms.
    • Date not recorded · recommends · Website ↗
      Recommends milk thistle as an herb that can help clear liver congestion and support its smooth functioning.

RAL Summary

Members OnlyTier 3 for Gallbladder and Fat Digestion

Tier 3 because 95% of 456 reviews are positive and there is some human study support, mainly a small trial where milk thistle lowered bile cholesterol and the tendency of bile to form stones [1]. The evidence is too limited and indirect for a higher tier.

Take 2 servings a day to match the dose that worked in the studies.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Digestive system, Liver and gallbladder

Combine with: Combine with a healthy diet and lifestyle.

Possible side effects: No major side effects reported.

Supplement Facts

Milk Thistle seed extract 300 mg
Supplement Facts
Serving Size 2 Veggie Capsule(s)
Servings Per Container 60
Amount Per Serving% Daily Value
Milk Thistle seed extract300 mg†
† Daily Value not established.

Other ingredients: Modified Cellulose, Microcrystalline Cellulose, Silicon Dioxide, Calcium Stearate.

Directions: Suggested Adult Use: Take 2 capsules daily before a meal, or as recommended by a nutritionally-informed physician.

Barcode (UPC) 753950003798 · Label source: NIH label database · Report a label change

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Graded November 10, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.