Double Wood Supplements Apigenin Review
Apigenin is a plant flavone bioflavonoid found throughout the plant kingdom, most abundantly in chamomile flower, the same compound responsible for much of chamomile tea's calming character. This supplement delivers a more concentrated form of the flavonoid than a cup of tea provides, in a single precise 50mg capsule. The page states that apigenin binds to GABA-A receptors in the brain, supporting a calming effect without the heavy sedation associated with pharmaceutical sleep aids. The page also describes apigenin's phytoestrogenic activity, meaning it can weakly interact with estrogen receptors. It notes preclinical research, mainly in animal and cell models, into apigenin's role in supporting ovarian function by helping protect ovarian cells against oxidative stress, and it states that human evidence in this area is still developing. Each bottle holds 120 capsules, a four-month supply at the standard one-capsule evening serving. The page says apigenin is naturally fat-soluble and recommends taking it alongside a meal or a small snack containing fat, such as a handful of nuts or a spoonful of yogurt, to support bioavailability. The product is listed as NSF Contents Certified and audited to NSF/ANSI 173. The page says every batch is tested for purity, potency, heavy metals and microbial safety, and that certificates of analysis are published openly. The directions suggest taking one capsule (50mg) 30 to 60 minutes before bedtime with a small source of dietary fat. Those who find 50mg insufficient may take two capsules before bed, and the page advises not to exceed two capsules per day. It notes that morning use is possible for daytime calm, although two morning capsules may be too sedating for some people. The page recommends pairing apigenin with Magnesium L-Threonate for brain-centred relaxation and with L-Theanine for mental quiet and physical relaxation. The certificate of analysis for lot 2617400 lists 48.30 mg apigenin against a 45 to 62.5 mg specification, a capsule weight of 138 mg, passing disintegration, and absent E. coli, Salmonella and Staphylococcus aureus. The page advises consulting a healthcare provider before use for anyone taking prescription sedatives, meds or meds, and for pregnant or nursing people, or those with estrogen-sensitive conditions.
We don’t sell supplements. We help you make decisions and get the best price.
Lowest prices
We may earn a commission from some store links. How we choose.
Lowest cost per month first, in stock, at 1 capsule a day. Checked Nov 9.
- VitacostLowest$29.99 a bottle$7.50/moBuy at Vitacost (opens in a new tab)
- PureFormulas$45.74 a bottle$11.44/moBuy at PureFormulas (opens in a new tab)
- Double Wood Supplements$47.41 a bottle$11.85/moBuy at Double Wood Supplements (opens in a new tab)
Also at: iHerb
Study, Trial or Testing Result Summary
Members Only1 human studies · 0 improved
Only one human study has looked at apigenin for sleep, and it did not test apigenin on its own. In this placebo-controlled trial, 103 healthy, active adults took an evening blend for 2 weeks. The blend contained 50 milligrams of apigenin, the same amount as in this product, together with magnesium L-threonate and L-theanine. Compared with placebo, the evening blend did not clearly improve sleep [1]. The sleep benefits seen in the trial came from a different group that took a morning product with ashwagandha and Rhodiola, not apigenin [1]. Because apigenin was mixed with other ingredients and the trial was short, it cannot tell us whether apigenin alone helps or does not help sleep [1]. The share of people whose sleep improved was not reported. Longer studies of apigenin by itself are needed before any firm conclusion can be drawn. Animal and cell studies are never counted.
See all 1 studies →Hide the studies
- In 103 healthy active adults, an evening blend containing 50 mg apigenin (plus magnesium L-threonate and L-theanine) taken for 2 weeks did not clearly improve sleep compared with placebo; the sleep benefits seen came from the morning ashwagandha and Rhodiola group.Modulating stress and sleep through a multi-compound dietary supplement: a randomized, double-blind, placebo-controlled …
Review Totals and Summary
Members Only1,035 reviews · 88% positive
Across both stores, the Double Wood Supplements Apigenin product has received 40 ratings. The themes below are drawn from the written reviews visible on their respective product pages, which included three written reviews on the Double Wood Supplements website and a number of written reviews on the Double Wood Supplements store page. Customer feedback on the Apigenin capsules primarily centers on their effectiveness for sleep. Many reviewers on the Double Wood Supplements store page report that the capsules significantly aid their sleep, helping them fall asleep more easily, stay asleep longer, and reduce instances of waking up during the night. The product is also noted for promoting relaxation without causing grogginess, which is a key benefit for users seeking a restful night. Some users specifically mention pairing Apigenin with magnesium L-Threonate, finding that this combination enhances the desired sleep benefits. While most feedback on sleep is positive, an AI-generated summary on one page indicates that opinions on effectiveness can vary, with some users finding it excellent for sleep while others perceive it as inactive. Regarding the physical attributes of the product, the capsules themselves are consistently described as small and easy to swallow, which is a positive point for users. Many reviewers express high satisfaction, frequently describing the product as "exactly what they needed" and indicating intentions to reorder. A notable concern raised by one reviewer on the Double Wood Supplements store page is a potential allergic reaction. This individual reported experiencing itchy eyes, sneezing, and a multi-day reaction that recurred upon a second attempt to use the product, leading them to suggest a possible allergy. This specific report highlights the importance of the allergy alert mentioned on the product page. Beyond the product itself, customers frequently praise the Double Wood Supplements brand and their overall store experience. While the three written reviews on the Double Wood Supplements website did not specifically discuss the Apigenin capsules, they offered general praise for the brand, describing Double Wood as their "go-to" for supplements. These general comments characterize Double Wood products as "great, effective, and clean" and offered at a "reasonable price." This sentiment of reasonable pricing is echoed by reviewers on the Double Wood Supplements store page who specifically mention the Apigenin capsules. Reviewers also commend the brand for its safety record and its commitment to US manufacturing, contributing to overall brand trust. The ordering experience is consistently praised across both sets of reviews, with customers highlighting reliable fulfillment, fast shipping, and a consistently good overall delivery and ordering process. The selection of products is also noted as being wide and satisfactory.
Biohacker Summary
Members Only8 of 10 recommend it
Apigenin is the only ingredient here, and the panel leans toward using or recommending it: of the ten, six currently use it, two recommend it, and three are neutral. The main reason is sleep, with most taking 50 mg before bed, though one takes 400 mg about 45 minutes before bed away from the evening meal and another suggests 100 mg a day for fat loss and longevity. Others point to its role in keeping NAD levels up, with parsley and chamomile tea named as food sources, and one pairs it with coffee to soften restlessness. Caution comes from one panelist who says data on sleep benefits is scarce and mostly comes from chamomile tea rather than isolated apigenin supplements.
See all 10 biohackers →Hide the biohackers
Thomas DeLauer · Apigenin · neutral
- Mentions apigenin also works well for clearing caffeine, but finds rutaecarpine more potent.
- Recommends apigenin for longevity and anti-aging activity, noting that it reversed graying hair, restored muscle strength, and recovered lung and spleen tissue in animal studies by shutting off inflammatory signals from aging cells.
- Recommends apigenin as a runner-up for sleep, stating it binds to GABA-A receptors similarly to meds but without the dependency risk.
- Recommends an apigenin supplement at 100 mg per day of pure apigenin for fat loss, hormone balance, longevity, and neuroprotection, noting it has the most mechanistic backing.
- Explains that apigenin can block some of the sleep-inhibiting effects of caffeine, allowing one to theoretically take caffeine later in the day and still sleep better.
- States that he combines his coffee with apigenin, which blocks calcium influx into cells, reducing the physical energy boost of caffeine without inhibiting its fat loss effects, to potentially increase fat loss while mitigating restlessness.
- Mentions that apigenin also increases SIP1A2 and suggests combining it with rutacarpine for a rapid deceleration of the caffeine bump up, as apigenin seems to work faster while rutacarpine is more effective.
- Mentions that apigenin also works well for clearing caffeine from the system, but rutacarpine seems more potent.
- Mentions that Apigenin also increases sip 1A2, similar to Rutaecarpine, and can be combined with Rutaecarpine to get caffeine out of the system quickly, also having a huge effect on blood glucose.
- Recommends trying apigenin to help offset some of the negative effects of caffeine on sleep.
Andrew Huberman · Apigenin · neutral
- Discusses Apigenin as a tool for falling asleep.
- Takes 50 mg of Apigenin before bed for sleep.
- Takes 50 mg of Apigenin before bed for sleep.
- Takes 50 mg of Double Wood Apigenin before bed for sleep.
- He takes 50 mg of Apigenin from Double Wood before bed for sleep.
- Takes 50 mg of Double Wood Apigenin before bed for sleep.
- Takes 50 mg of apigenin before bed for sleep.
- Takes 50 mg of Apigenin before bed for sleep.
- Discusses Apigenin as a sleep supplement.
- Recommends Apigenin as one of three main supplements for improving the ability to fall and stay asleep, suggesting 50 milligrams, taken 30 to 60 minutes before bedtime.
Bryan Johnson · Apigenin · uses
- Takes 50 mg of Apigenin before bed for sleep.
- Takes 50 mg of Apigenin before bed for sleep.
- Takes 50 mg of Apigenin before bed for sleep.
- He takes 50 mg of Apigenin before bed for sleep.
- Takes 50 mg of Apigenin before bed for sleep.
- Takes 50 mg of Apigenin before bed for sleep.
- Takes 50 mg of Apigenin before bed for sleep.
- Takes 50 mg of apigenin before bed for sleep.
- He takes 50 mg of Apigenin before bed for sleep.
- Takes 50 mg of Apigenin before bed for sleep.
Siim Land · Apigenin · neutral
- Mentions apigenin as a phytochemical that has been shown to stimulate GLP-1 expression directly, and also increase glucose uptake and insulin sensitivity.
- He takes 50 mg of Apigenin before bed for sleep.
- Takes 50 mg of Double Wood Apigenin before bed for sleep.
- He takes 50 mg of apigenin before bed for sleep.
- Takes 50 mg of Apigenin before bed for sleep.
- Notes that there isn't much long-term research on substances like apigenin for sleep and anxiety, and replication is a problem due to varying product formulations. He also points out a lack of follow-up on people after they discontinue supplementation.
- Likes Apigenin as a CD38 inhibitor that helps with NAD metabolism, increasing energy levels and lowering inflammation, but notes limited evidence for its other effects.
- Mentions apigenin as a senolytic compound that helps eliminate senescent cells, which accumulate during aging and spread inflammation.
- Believes that inhibiting CD38 with something like Apigenin would be part of a longevity stack and strategy for long-term longevity, placing it in the 'okay tier' despite limited evidence for extending animal lifespan.
- Recommends Apigenin for longevity, stating it's a good supplement for sleep and has anti-cancer benefits, suggesting a dose of 50-100 mg.
Dave Asprey · Apigenin · uses
- Dave Asprey takes 400 mg of apigenin every night for sleep quality, noting it binds to the same receptor as a med and has 12 randomized trials supporting its effect on sleep quality, despite most products being underdosed.
- Recommends taking 400 mg of apigenin about 45 minutes before bed, away from the evening meal, to help with sleep by gently turning down the brain's GABA system.
- Recommends apigenin, highly concentrated in chamomile tea, as a plant compound that directly slows down the demolition crew inside cells, which destroys NAD+.
- Dave Asprey recommends apigenin, a plant compound highly concentrated in chamomile tea, as it has been shown to directly slow down the demolition crew inside cells that breaks down NAD+.
- He takes 50 mg of Apigenin from Double Wood before bed for sleep.
- Takes Apigenin most days, noting it's a well-known longevity supplement that helps downregulate CD38, preserving NAD levels and decreasing inflammatory response.
- Explains that apigenin is used as a CD38 inhibitor, but taking it in its pure form is not effective.
- Recommends using apigenin to fix PARP enzymes, which deplete NAD.
- Explains that apigenin is a good inhibitor of CD38, a major consumer of NAD, and is known to boost NAD levels by up to 50% in cells.
- Notes that apigenin, a cognitive-enhancing nootropic, has shown a pretty good effect as a senolytic in some studies.
Dr. Mark Hyman · Apigenin · uses
- Takes 50 mg of Double Wood Apigenin before bed for sleep.
- Takes 50 mg of Apigenin before bed for sleep.
- Takes 50 mg of Apigenin before bed for sleep.
- Takes 50 mg of Apigenin before bed for sleep.
- Takes 50 mg of apigenin before bed for sleep.
- Takes 50 mg of apigenin before bed for sleep.
- Takes 50 mg of apigenin before bed for sleep.
- Takes 50 mg of apigenin before bed for sleep.
- Takes 50 mg of Apigenin before bed for sleep.
- Takes 50 mg of Apigenin before bed for sleep.
Ben Greenfield · Apigenin · neutral
- Notes a new study indicating that apigenin is a core dietary antioxidant closely associated with a reduced risk of accelerated biological aging, and mentions it is found in parsley.
- States that Nuchido Time Plus includes apigenin from parsley extract, which is a good inhibitor of CD38, an enzyme that wastes NAD+ and drives inflammation.
- Takes 50 mg of Apigenin before bed for sleep.
- Takes 50 mg of Apigenin before bed for sleep.
- He takes 50 mg of Apigenin from Double Wood before bed for sleep.
- Takes 50 mg of Apigenin before bed for sleep.
- Takes 50 mg of Apigenin before bed for sleep.
- He takes 50 mg of Apigenin from Double Wood before bed for sleep.
- He takes 50 mg of Apigenin before bed for sleep.
- He takes 50 mg of Apigenin before bed for sleep.
Dr. Rhonda Patrick · Apigenin · uses
- Rhonda takes 50 mg of Apigenin before bed for sleep.
- Uses apigenin 30 minutes before sleep.
- Dr. Patrick explains that apigenin, a flavonoid in parsley and celery, causes neural stem cells to form new neurons, strengthens neuronal connections for learning and memory, and has been shown to kill cancer cells.
- States there is very little data to support strong claims about apigenin's ability to improve sleep and advises against apigenin supplements due to lack of evidence and concerns about reputable sources.
- Dr. Rhonda Patrick discusses apigenin, a flavonoid in parsley and celery, for its ability to cause neural stem cells to form new neurons, strengthen neuronal connections for learning and memory, and kill cancer cells.
- She states there is scarce data on apigenin's effects on improving sleep, with most evidence related to chamomile tea rather than isolated apigenin supplements.
Peter Attia · Apigenin · uses
- Takes apigenin, which is a CD38 inhibitor, to effectively increase NAD levels by blocking the enzyme that consumes NAD.
- Takes 50 mg of Thorne Apigenin before bed for sleep.
Dr. Eric Berg · Apigenin · recommends
- Recommends Apigenin as one of five compounds that boost NAD to help slow aging, with parsley being the best source.
- States that Apigenin, a polyphenol found in celery juice, acts as a muscle relaxer, lowers blood pressure, and improves sleep.
- Explains that Apigenin, a compound in celery juice, is a good muscle relaxer, can lower high blood pressure, improve sleep, and has anti-diabetic properties, even being used to help people with amnesia.
- Mentions apigenin, a phytochemical found in certain foods, as being researched for its natural inhibition of autophagy as a strategy for cancer.
- Highlights apigenin, a phytonutrient in celery, as having a powerful effect on blood sugars, improving insulin sensitivity and conditions like insulin resistance.
- Mentions that celery contains apigenin, a powerful anti-cancer phytonutrient also found in parsley and other vegetables.
- Describes apigenin as a powerful phytonutrient that can create effects similar to chemotherapy and anti-cancer effects without the side effects.
- Does not recommend taking apigenin in a pill form, suggesting that consuming celery is the best way to get its benefits.
- Explains that apigenin, found in celery, parsley, chamomile tea, and grapefruit, is a compound that is anti-anxiety, can act as a sedative, is anti-diabetic, anti-cancer, has anti-inflammatory properties, and inhibits aromatase.
- Recommends consuming foods high in apigenin, especially for those on medication or chemotherapy, as it induces autophagy, detoxifies drugs, reverses drug resistance in cancer treatment, prevents kidney damage, stimulates neurogenesis, and decreases amyloid plaque.
RAL Summary
Members OnlyTier 4 for Sleep
The ineffective grade rests on a single short trial that tested apigenin only inside a blend with magnesium L-threonate and L-theanine, so it cannot show that apigenin alone does not work, and the evidence is thin rather than negative. So it is graded Tier 4, as the studies disagree.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 1 of the 1 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Nervous system
Combine with: To enhance the sleep-promoting effects of Apigenin, consider combining it with supplements that support various aspects of sleep and relaxation. Melatonin can be a good addition, as it helps regulate the sleep-wake cycle. Magnesium is another excellent choice, known for its role in muscle relaxation and nervous system calming, which can contribute to deeper sleep. L-Theanine, an amino acid, can promote relaxation and reduce anxiety without causing drowsiness, complementing Apigenin's calming properties. Finally, other herbal extracts like Valerian root or Chamomile can offer additional synergistic benefits for overall sleep quality and relaxation.
Possible side effects: The study reported no side effects. One reviewer described a possible allergic reaction with itchy eyes and sneezing lasting several days that returned when they tried the product again.
Supplement Facts
Apigenin 50 mg
| Apigenin | 50 mg | † |
Other ingredients: Hypromellose (capsule), Microcrystalline Cellulose, Vegetable Stearate and Silica.
Directions: Take 1 capsule per day. To support sleep, take at dinner or before bed with a source of dietary fat.
Label source: Doublewoodsupplements · Report a label change
Show entire label
More sleep products
Members OnlyThe highest ranked for the same goal
Read more
Our articles on this subject
- Melatonin vs Magnesium for Sleep: What the Studies ShowArticle · Nov 3, 2026
- Best Supplements for Sleep and the Habits That Matter MoreArticle · Jun 15, 2026
Graded October 26, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
Privacy policyConsumer health dataAffiliate disclosureTermsDo Not Sell or Share My Personal InformationCookie settings