Dr. Clark Store Lysine 475 mg Review
This Dr. Clark Store product is listed in the Dietary Supplement Label Database as Lysine 475 mg, sold as a capsule supplement under the brand Dr. Clark Store. The label lists the product as on market, with a date entered into the database of 22 May 2020 and DSLD ID 219980. The net contents are 100 capsules. The product type is classified as Amino acid/Protein, and the supplement form is Capsule. The listed dietary claims are Nutrient, All Other, and Structure/Function, and the intended target group is adults aged 18 to 50 years. The Supplement Facts panel gives a serving size of 1 capsule with 100 servings per container. Each serving provides 475 mg of L-Lysine, listed as L-Lysine Hydrochloride, with the Daily Value shown as not established. The other ingredients are gelatin capsules only. The label states that the product does not contain flow agents such as magnesium stearate. The formula is described as containing an essential amino acid. The label carries the seals Made in USA and GMP Quality Assured. The suggested use is to take 1 capsule, or as directed by a healthcare professional. The label includes precautions advising that anyone who has an adverse reaction should stop use and consult a doctor, that the product should be kept away from children, and that pregnant or nursing women or people taking meds should consult a doctor before use. If the seal under the cap is damaged or missing, the label advises not to use the product. The storage instruction is to store at room temperature. The FDA disclaimer states that the statements have not been evaluated by the Food and Drug Administration and that the product is not intended to diagnose, treat, cure or prevent any disease. The brand information names Dr. Clark Store of Chula Vista, California as the manufacturer. The label gives a company address in Chula Vista, a toll free customer service number, and the website www.DrClarkStore.com. The label notes that the company was established by Dr. Clark's family in 1993 and describes itself as a leader in purity. It also states that the company does not adopt any Dr. Clark claims. The page offers a watch option so that users can be emailed if the formula changes, the product is discontinued, the product is recalled, or the price drops. The page also links to other Dr. Clark Store labels and to other labels that contain lysine.
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Study, Trial or Testing Result Summary
Members Only9 human studies · 6 improved
Lysine has some human trial support for immune function, mostly in people with low-protein diets or specific health conditions. In northern Chinese farm families, lysine-fortified flour for three months raised T cell counts and several antibody and complement levels compared with regular flour [1]. A similar trial in rural Syria found only small gains: higher complement in men and fewer diarrhea episodes in women, with no other immune differences [2]. In people with frequent herpes outbreaks, 3,000 milligrams daily for six months led to about 2.4 fewer outbreaks, milder symptoms and faster healing than placebo [3]. In people with type 2 diabetes, 3 grams daily for three months raised the activity of the germ-fighting enzyme lysozyme [4]. This product gives 475 milligrams a day, well below the 3,000 milligrams that worked in these trials. In an older herpes trial, 1,248 milligrams daily seemed to reduce recurrences but did not speed healing, and 624 milligrams daily did not work [5]. That suggests a dose this low may not give the benefits seen in the studies [5]. Animal and cell studies are never counted.
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- In 88 farm families (a man, a woman and a child each) in northern China, wheat flour fortified with lysine for three months raised T cell counts and several antibody and complement levels compared with unfortified flour.Lysine-fortified wheat flour improves the nutritional and immunological status of wheat-eating families in northern Chin…
- In rural Syrian families given lysine-fortified wheat flour for 16 weeks, men had higher complement C3 and women had fewer diarrhea episodes than controls, but no other immune differences were seen.Impact of lysine-fortified wheat flour on morbidity and immunologic variables among members of rural families in northwe…
- In 83 patients after sinus surgery, a nasal spray containing lysine hyaluronate used for 4 weeks alongside saline reduced symptoms, endoscopic findings and inflammatory cells more than saline alone.Intranasal T-LysYal® as adjunctive therapy for patients after functional endoscopic sinus surgery.
- In 52 people with frequent recurrent herpes, 3,000 mg of L-lysine daily for 6 months led to about 2.4 fewer infections, milder symptoms and faster healing than placebo.Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis.
- In 50 people with type 2 diabetes, 3 g of L-lysine daily for three months reduced advanced glycation products and increased the activity of the germ-fighting enzyme lysozyme compared with controls.The Preventive Effect of L-Lysine on Lysozyme Glycation in Type 2 Diabetes.
- In 41 people with recurrent herpes, 1,248 mg of lysine daily appeared to reduce recurrences but did not shorten healing time, and 624 mg daily was not effective.Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride.
- In 21 healthy adults with frequent recurrent herpes, 1,200 mg of lysine daily showed no clear benefit over placebo for treating or preventing episodes.Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis.
- In people with recurrent infections, a lysine and arginine combination increased neutrophil movement and certain lymphocyte and antibody levels.Effects of lysine-arginine association on immune functions in patients with recurrent infections.
- In laboratory and animal experiments on liver cancer, cancer cells took up lysine that immune T cells need, and adding lysine made cancer treatment work better, but this was not tested in people.SLC3A2-Mediated Lysine Uptake by Cancer Cells Restricts T-cell Activity in Hepatocellular Carcinoma.
Review Totals and Summary
Members Only65 reviews
I found no reviews specific to this exact product on a retailer page. The summary therefore combines two kinds of feedback. The first is reviews of the Dr. Clark Store itself on Trustpilot. The second is general lysine user reviews on Drugs.com. Treat it as indicative of this product, not as direct feedback on it. On the store side, customers repeatedly praise fast shipping and careful packing. They say orders arrive well protected, and some mention advance notice of delivery. Many like the clear dosage charts and the step-by-step protocol instructions that come with the products. They also like being able to find the Clark products in the combinations the protocols call for. Several reviewers call the products high quality. Others describe the company as quick to answer questions by email or social media. Loyal repeat buyers say they are very pleased with how well the products work. Some are hopeful but tentative, with comments such as the product "seems to work" or that they have not tried it yet. Complaints are fewer. One is about delivery that requires waiting at home all day with no real-time tracking. One reviewer says customer service was poor. Another says they did not realize they should avoid a product because of hip implants, which points to a wish for clearer warnings. For lysine in general, users most often take it against cold sores and herpes outbreaks. Many say it works best when started at the first tingle or itch, often at higher doses for a day or two and then at a lower daily dose. Several say it stopped or shortened outbreaks, or that they went long stretches without one when taking it daily. Others report that it was less effective once a sore was already forming, or that outbreaks returned after months. A few mention side effects or discomfort with daily use, such as one person who felt restless-leg-like symptoms and foot pain. Dose preferences differ widely between reviewers, and some use far more than a 475 mg capsule provides. Taken together, the feedback is positive on service and convenience, and mixed on lysine's effectiveness for each person.
Biohacker Summary
Members Only6 of 10 recommend it
Only three of the ten panelists spoke about lysine, the main ingredient in this product, and two of them recommend it while the third was neutral in the most recent statement. They mainly take it against viruses, such as herpes, cold sores, shingles and viral reactivation, with one also recommending it for thicker hair and another for connective tissue health. One panelist suggests at least 600 milligrams once or twice a day for shingles and 3000 milligrams for intense cases, and the panel favors either a supplement or foods high in lysine and low in arginine. One recommends pairing it with high-dose IV vitamin C, and one raised the question of whether a broad amino acid supplement containing arginine could weaken its effect on cold sores. No one said they stopped taking it, and no one gave a specific caution.
See all 3 biohackers →Hide the biohackers
Dr. Eric Berg · L-Lysine · recommends
- Recommends L-lysine because it competes with L-arginine, which the virus needs to reproduce, thus blocking the virus from getting arginine and starving it off.
- Recommends taking an L-lysine supplement or consuming foods high in L-lysine for thicker hair.
- Recommends L-lysine for shingles.
- Recommends eating foods high in l-lysine or taking l-lysine supplements to put the herpes virus into remission, especially if consuming foods high in arginine. For intense cases, 3000 milligrams is recommended.
- Recommends taking at least 600 milligrams of L-lysine once or twice a day to help with shingles.
Dr. Mark Hyman · L-Lysine · recommends
- Recommends pairing high-dose IV vitamin C with L-lysine, an amino acid with an antiviral component, for viral reactivation.
- Dr. Hyman mentions that L-Lysine, an amino acid, can help inactivate the Epstein-Barr virus and is often taken to prevent herpes outbreaks.
Ben Greenfield · L-Lysine · neutral
- Angie is wondering if taking a broad spectrum amino acid supplement with L-arginine would inhibit the effectiveness of L-lysine for cold sores.
- Ben says that L-lysine is really important for connective tissue health and can have a significant effect on cold sores, recommending a lysine supplement or foods high in lysine and low in arginine.
RAL Summary
Members OnlyTier 4 for Immune Health
The review summary is built from Trustpilot feedback about the Dr. Clark Store as a seller and from general lysine reviews on Drugs.com, not from reviews of this product, so it is set aside. Its reviews are set aside, so it is graded on its studies alone. Its studied ingredients are not at the doses that worked in studies, and reviews are not strong enough on their own.
- Emerging: not enough evidence to rank higher yet.
- L-Lysine: below the dose that worked in studies
Where the evidence disagrees: 1 of the 9 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Immune system
Combine with: For immune and cold sore support, pair lysine with vitamin C and bioflavonoids (collagen and immune function), zinc (immune defense and tissue repair), and vitamin D3 with K2. Propolis or lemon balm may add antiviral support. If the underlying interest is cellular and DNA repair, consider adding NMN or NR with resveratrol or pterostilbene, CoQ10 or PQQ for mitochondrial support, alpha-lipoic acid, and glutathione or NAC for antioxidant protection. Lysine can also be stacked with proline and vitamin C for collagen support. Consult a healthcare provider before use, especially with kidney issues or calcium supplementation.
Possible side effects: No major side effects reported in the studies given; no reviews of this exact product were available.
Supplement Facts
L-Lysine 475 mg
| L-Lysine | 475 mg | † |
Other ingredients: Gelatin Capsules.
Directions: Suggested Use: Take 1 capsule, or as directed by a healthcare professional.
Barcode (UPC) 652384105637 · Label source: NIH label database · Report a label change
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Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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