Earth Friend Herb Co. St. John's Wort Review
We don’t sell supplements. We help you make decisions and get the best price.
Lowest prices
We may earn a commission from some store links. How we choose.
We found no store selling it right now.
Study, Trial or Testing Result Summary
Members OnlyHuman studies
No study in people has tested St. John's Wort or its hypericins for aging, biological age or cellular repair. All the evidence here comes from rats and mice, so whether it applies to people is unknown, and it is unclear how this product's 333 milligrams of herb and 0.9 milligrams of hypericins compare with the animal doses. In rats with aluminum-induced Alzheimer-like brain damage, 60 days of the extract improved memory and thinking and lowered brain oxidative stress and inflammation [1]. In rats with drug-induced anxiety, 21 days of extract lowered brain oxidative stress, inflammation and stress hormones [2]. In mice with a multiple sclerosis model, six weeks of extract in food reduced brain oxidative stress and loss of the nerve coating [3]. Single doses lowered oxidative stress after blood-flow injury in rat testes [4] and rat kidneys [5]. Purified hypericin reduced heart damage and helped the cell's energy factories in rats after a blocked blood supply [6], and eased depressive-like behavior and oxidative stress in mice [7]. None of these studies measured biological age. Animal and cell studies are never counted.
Review Totals and Summary
Members Only1,300 reviews · 90% positive
Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.
Biohacker Summary
Members Only0 of 10 recommend it
Five of the ten panelists spoke about St. John's wort, and they are split between mild support and caution. Most of those five link it to low mood and stress, and one also mentioned it for seasonal low mood, sleep, and support when quitting smoking. One panelist recommends it as a natural option for depression and says it has few side effects, while another said it worked for all but the most severely depressed people in a study. Forms mentioned were a homemade tincture and a dried herb tea, and no doses were given. Two panelists warn that it can cut the effectiveness of birth control and meds or hold back the liver's detox system, and a few others stayed neutral, with one saying a person should test first to see if the body needs it.
See all 5 biohackers →Hide the biohackers
Dr. Eric Berg · St. John's Wort · recommends
- Recommends St. John's wort as a natural a med to help improve the symptoms of depression.
- Suggests St. John's Wort as an alternative for depression, highlighting its better benefit-to-harm ratio compared to a med drugs.
- Notes that St. John's wort works better than meds for depression, with 70% results compared to 60% for the drug, and fewer side effects.
- Notes that St. John's wort affects both serotonin and dopamine, is an anti-inflammatory, and reduces cortisol, but doctors often recommend against it despite its few side effects.
- Warns that St John's Wort inhibits the detoxification system in the hepatocyte, which can lead to the retention of chemicals in the body, especially when combined with medications.
- Mentions that St. John's Wort is commonly thought of to help regulate serotonin for depression.
- Recommends St. John's wort for depression or anxiety if one is not taking other medications, due to its effectiveness, but warns that it must be taken under supervision if on other medications, especially psychiatric drugs, due to complications and indirect liver damage.
- Warns against taking St. John's Wort at the same time as a selective serotonin reuptake inhibitor, as it can lead to too much of a certain neurotransmitter and create other problems.
- Recommends St. John's Wort as great for earaches and ear infections.
- Recommends St. John's wort as an antiviral and anti-microbial to help with infections or chronic systemic immune weakness.
Dr. Mark Hyman · St. John's Wort · warns
- Mentions that St. John's wort can reduce the effectiveness of birth control and meds.
- Discusses a study funded by a pharmaceutical company that claimed St. John's Wort didn't work, but upon reading the study, it did work for all but the most severely depressed people.
- Discusses a study on St. John's Wort funded by a pharmaceutical company, noting that while the headline claimed it didn't work, the study actually showed it did work for most people, except the most severely depressed.
Ben Greenfield · St. John's Wort · neutral
- Mentions St. John's Wort as a natural herbal approach some people utilize for sleep.
- Mentions St. John's Wort as something that can help with quelling tobacco/nicotine addiction.
- Ben Greenfield and his sons harvest St. John's Wort to make a tincture, which he calls the "happy flower" and notes it contains compounds similar to meds without the side effects.
- States St. John's Wort can be used to ward off seasonal affective disorder.
- Recommends St. John's wort as a basic supplement to support the adrenal glands when quitting smoking.
- Mentions St. John's wort as an anti-depressant and describes a method of preparing it by putting it in vodka for 4 weeks and then straining it.
- Mentions his sons harvested St. John's Wort, which they prepare in vodka as a tincture to use in winter, stating it acts like a med a med without negative side effects.
- Recommends St. John's Wort, a yellow flower extract, for depressive symptoms, noting it's more effective than meds with fewer adverse effects.
- Recommends St. John's Wort as an herbal a med proven effective in mild or moderate depression states with fewer side effects than meds.
- Ben mentions St. John's wort as an herb traditionally used for depression or anxiety, but warns against combining it with medical anti-depressant drugs.
Dave Asprey · St. John's Wort · neutral
- Went through a phase of using St. John's Wort, especially for people who didn't want to try pharmaceutical agents for depression.
- Mentions that one can make an argument for St. John's Wort but emphasizes focusing on what the body needs.
- Dave Asprey's grandma and great-grandma would pick St. John's Wort from the side of the highway, dry it, and make tea, which he later learned is good for depression.
Thomas DeLauer · St. John's Wort · neutral
- Mentions St. John's Wort as a good supplement but questions if the body actually needs it without proper testing.
- The video title indicates that St. John's Wort reduces stress.
- Explains that St. John's Wort, also known as Hypericum perforatum, is showing to help relieve depression and stress, and can positively improve and reduce biomarkers of stress.
RAL Summary
Members OnlyTier 3 for Healthy Aging
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Nervous system, Cardiovascular system, Renal system, Reproductive system
Combine with: Combine with a healthy diet and lifestyle.
Possible side effects: No major side effects reported.
Supplement Facts
Organic St. John's Wort 333 mg · Hypericins 0.9 mg
| Organic St. John's Wort | 333 mg | † |
| Hypericins | 0.9 mg | † |
Other ingredients: Organic rice hulls, organic vegan capsule (organic pullulan), and organic maltodextrin.
Label source: Reverseagelab · Report a label change
Show entire label
More healthy aging products
Members OnlyThe highest ranked for the same goal
Read more
Our articles on this subject
- Healthy Aging Tips: A Science-Backed Guide to Living Better for LongerArticle · Mar 17, 2026
- NAD Anti-Aging Supplements: Benefits, Evidence, and How to ChooseArticle · Jun 15, 2026
Graded November 14, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
Privacy policyConsumer health dataAffiliate disclosureTermsDo Not Sell or Share My Personal InformationCookie settings