Elements of Health Care L-Arginine Plus Grape Review

The Elements of Health Care L-Arginine Plus Grape is a powder dietary supplement listed in the Dietary Supplement Label Database under DSLD ID 239623, with a bar code of 8 52433 00601 8 and a net content of 13.4 ounces (380 grams). The label places the product in the Other Combinations product type and classifies its supplement form as powder. The listed dietary claims are Nutrient, All Other and Structure/Function, and the intended target group is adults aged 18 to 50 years. The product is labeled gluten free and made in the USA in a GMP compliant facility. The serving size is 12.7 grams, with 30 servings per container. Each serving supplies 35 calories and 4 grams of total carbohydrates. The vitamin and mineral content includes 60 mg of vitamin C as ascorbic acid (100% Daily Value), 2,500 IU of vitamin D3 (625% DV), 20 mcg of vitamin K (25% DV), 2 mg of vitamin B6 as pyridoxine hydrochloride (100% DV), 400 mcg of folate as folic acid (100% DV), 6 mcg of vitamin B12 as cyanocobalamin (100% DV), and 20 mg of magnesium (5% DV). The active components listed are 5,110 mg of L-arginine, 1,010 mg of L-citrulline, 100 mg of red wine extract, 50 mg of AstraGin, and a proprietary blend of 72 trace minerals at 100 mg. Daily Values are not established for these non-vitamin components. The label statements describe the formula as enhanced with AstraGin and as a new and improved formula now containing 5110 mg of L-arginine. Each scoop is stated to provide 5,110 mg of L-arginine and 1,010 mg of L-citrulline. The label also describes the product as a cardio health formula and nitric oxide booster. Directions say to mix one scoop of L-Arginine Plus powder with 4 to 8 ounces of water, stir to dissolve, and note that cold water may take longer to dissolve. The label advises taking the product between meals or on an empty stomach. The precautions state to consult a health care provider before use if pregnant, nursing, taking meds, or having a known serious medical condition. Storage instructions say to keep the product in a cool dry place. The FDA disclaimer states that the statements have not been evaluated by the Food and Drug Administration and that the product is not intended to diagnose, treat, cure or prevent any disease. The page cites NIH as the brand information source, dated December 2020, with the date entered into DSLD as 26 December 2020. The page does not show a retail price, customer ratings, or written reviews.

Product Focus: CirculationAlso covers:HeartRanked among:Nitric oxide supplements
Tier ⓘ
Tier 4 · Rank 13
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 13 within Tier 4 for Circulation; 38 of 56 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
35 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
– no stars shown, 27 reviews
Biohacker Mentions
10 of 10

Study, Trial or Testing Result Summary

Members Only350 human studies · 194 improved

60 of these 350 human studies gave the ingredient by drip or injection, not by mouth.

350 human studies194 improved106 no effect37,535 people studied

The main ingredient, L-arginine, is at a full dose, but its results for blood flow are mixed. The largest trial, in 133 people with leg artery disease, found 3 grams daily for 6 months did not improve vessel widening, and walking improved less than with placebo [1]. Small short trials found better arm artery widening after a single 6 gram dose [2] and after 16 grams daily for 2 weeks in adults over 70 [3]. In 19 older adults, 4 days of use worsened small vessel function [4]. Citrulline reaches a full dose at two servings a day, and a review of 8 trials found it improved vessel widening but not overall artery stiffness [5]. Folate is at a full dose. One trial found 400 micrograms daily improved vessel widening [6], while another found only the 5 milligram dose helped [7]. Red wine extract is at a studied dose, and pooled trials of resveratrol found better vessel widening [8]. Vitamin C, vitamin K, vitamin B6 and magnesium are below the doses studied. AstraGin has only been tested indirectly, through an injected notoginseng extract given in hospital [9]. The 72 trace mineral blend has no studies. Animal and cell studies are never counted.

See all 350 studies →Hide the studies

Review Totals and Summary

Members Only27 reviews
27 reviews · EBay 27

Customers most often praise the taste and the perceived effect on blood pressure. Several buyers describe the grape flavor as pleasant and easy to drink. One Walmart reviewer said they had searched for years for an L-arginine that tastes good and works. Amazon reviewers are more measured about flavor. One compared the grape flavor to nostalgic Kool-Aid, and another called it passable but not bad. One reviewer also contrasted this red grape "Plus" with the blue "Complete" version, saying Complete has a slightly more chemical hint. Overall, the powder is described as tolerable to enjoyable, which matters because competing powders are often called hard to swallow. On results, buyers frequently say they use it for blood pressure, cholesterol and general circulation. Many were prompted by a doctor. One Amazon reviewer said their doctor suggested it to help lower blood pressure. A Walmart buyer who was told to take it for cholesterol said they would wait for blood work to see whether it helped. Others report steady energy through the day and better blood flow, with one saying it "works great." Some of these accounts are anecdotal and early. They often come after only days or weeks of use, and several reviewers are still waiting on lab results. Some reviewers also report a quick effect on a specific symptom within about three days. Shipping and product accuracy get brief positive mentions. One reviewer said delivery was quick and the product was as described. Negative feedback is thin. The Walmart page shows a small number of reviews, and a few are three-star. Those lower ratings come without a clear complaint in the text I saw. The recurring caveats are the artificial, Kool-Aid-like flavor and uncertainty about whether it works. One Amazon reviewer also noted that a similar competing canister looked nearly identical to this one in label wording, ingredients, potency and taste. That points to brand-clone confusion in this category. Reviewers also use varied listing names for this product, which suggests the listings are inconsistent across sellers. Ratings are broadly favorable on Walmart and Amazon. Walmart shows only 7 written reviews, so that sample is small. The Amazon listing is larger, with 1,415 ratings. I could only read a few reviews from each site, so these themes are not a full count of what buyers say. Some general L-arginine user reviews on WebMD also mention herpes flare-ups and heart-rhythm concerns. Those reviews are about L-arginine in general and not this product.

Biohacker Summary

Members Only10 of 10 recommend it
10 of 10 biohackers on our panel recommend it

The main ingredient here is folate, and the panel's view of it is favorable but thin on details: of the eight who spoke on it, four recommend it and the other four are neutral. Those who recommend it point to methylfolate, an active form the body can use directly, and one suggests getting enough through a prenatal vitamin for women preparing for IVF. Others value folate for its role in cell energy, for preventing a birth defect of the spine, and for lowering homocysteine, while the neutral comments note that birth control pills deplete it and that it can change how the body responds to a supplement. Two panelists spoke about citrulline, which one recommends for muscle recovery and clearing ammonia during exercise and the other treats neutrally as a way to raise arginine; no one gave a dose for folate or citrulline, and no one reported stopping or voiced a caution about either. Vitamin D, magnesium, vitamin C and vitamin K are smaller ingredients in this product, and panelists commonly take or recommend them for sleep, bone and muscle health, or general health.

See all 10 biohackers →Hide the biohackers
  • Dr. Mark Hyman · Folate · neutral
    • 21 Oct 2026 · neutral · YouTube ↗
      Notes that taking folate can lower homocysteine levels, which has shown health benefits and physical improvements in brain scans in clinical trials.
    • 1 Nov 2026 · Magnesium · uses · Facebook ↗
      Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
    • 26 Oct 2026 · Vitamin D · recommends · Facebook ↗
      Recommends Vitamin D for health, stating that amazing things happen when patients' vitamin D statuses reach optimal levels.
    • 21 Oct 2026 · Magnesium · recommends · YouTube ↗
      Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
    • 21 Oct 2026 · Vitamin D · neutral · YouTube ↗
      Mentions vitamin D as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
    • 19 Oct 2026 · neutral · YouTube ↗
      Notes that some people may need a little bit extra folate with a supplement.
    • 19 Oct 2026 · Vitamin D · neutral · YouTube ↗
      Notes that vitamin D plays a role in immune function.
    • 14 Oct 2026 · Magnesium · recommends · TikTok ↗
      Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
    • 12 Oct 2026 · Magnesium · recommends · YouTube ↗
      Recommends magnesium as a basic supplement during detoxification to support pathways, help with constipation, and provide electrolytes.
    • 12 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
    • 8 Oct 2026 · Vitamin D · recommends · Instagram ↗
      Recommends checking vitamin D levels and states that if they had to pick one single intervention for immune health, vitamin D would be it.
    • 7 Oct 2026 · Magnesium · recommends · YouTube ↗
      Recommends Magnesium Breakthrough Advanced 10 from Biooptimizers, which contains 10 bioavailable forms and 550 mg of elemental magnesium, to support restful sleep, restorative sleep, muscle recovery, stress resilience, and metabolic health.
    • 7 Oct 2026 · Vitamin D · neutral · Podcast ↗
      Dr. Hyman discusses vitamin D in relation to sun exposure patterns.
    • 7 Oct 2026 · Vitamin D · recommends · YouTube ↗
      States that vitamin D supplementation can help with oxidative stress.
  • Dr. Eric Berg · Folate · neutral
    • 19 Oct 2026 · neutral · YouTube ↗
      Notes that birth control pills deplete the body of folate, which is needed for the brain to make serotonin.
    • 2 Nov 2026 · Vitamin D · warns · Facebook ↗
      Dr. Berg warns that the recommended daily intake for vitamin D is based on a massive error and that the actual necessary amount is closer to 8,895 IU, with millions remaining deficient.
    • 31 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends getting vitamin D levels tested to ensure they are between 50 and 70, as vitamin D is intimately involved in regulating prostate size.
    • 31 Oct 2026 · Vitamin K · recommends · Podcast ↗
      Discusses foods that contain Vitamin K2.
    • 30 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends taking at least 10,000 IUs of vitamin D3 every single day in the winter, stating it is the most important vitamin to lower cancer risk.
    • 30 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends vitamin D to support the immune system, aiming for blood levels between 80 to 100 ng per ml.
    • 30 Oct 2026 · Magnesium · neutral · Instagram ↗
      Dr. Eric Berg states that magnesium supports energy, muscle function, and sleep, and that most of it is stored inside cells, making deficiencies harder to detect with a standard blood test.
    • 28 Oct 2026 · Magnesium · neutral · YouTube ↗
      Notes that magnesium could also be a factor in preventing muscle cramps.
    • 26 Oct 2026 · Vitamin C · neutral · YouTube ↗
      Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
    • 25 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends taking no less than 10,000 IU's of vitamin D3 for osteoporosis, alongside magnesium and K2.
    • 25 Oct 2026 · Vitamin D · recommends · X ↗
      Recommends increasing vitamin D to restore balance and support healthy blood pressure.
    • 25 Oct 2026 · Vitamin K · recommends · YouTube ↗
      Recommends taking 40 to 45 milligrams of vitamin K2 daily for osteoporosis, citing a study from Japan with great results.
    • 25 Oct 2026 · Magnesium · recommends · YouTube ↗
      Recommends magnesium, specifically magnesium glycinate, stating it is key for D3 and K2 to work and is probably more important than calcium for building bone.
    • 25 Oct 2026 · Magnesium · recommends · X ↗
      Recommends increasing magnesium to restore balance and support healthy blood pressure.
  • Dave Asprey · Folate · neutral
    • 17 Oct 2026 · neutral · Facebook ↗
      States that folate can affect how the body responds to a supplement.
    • 1 Nov 2026 · Vitamin D · uses · Facebook ↗
      Takes Vitamin DAKE from Suppgrade Labs.
    • 31 Oct 2026 · Magnesium · neutral · YouTube ↗
      Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
    • 25 Oct 2026 · Vitamin D · recommends · Podcast ↗
      Suggests that vitamin D supports brain health, muscle function, and focus.
    • 25 Oct 2026 · Magnesium · recommends · Podcast ↗
      Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
    • 24 Oct 2026 · Vitamin C · recommends · Facebook ↗
      Recommends taking vitamin C for better skin health.
    • 17 Oct 2026 · Magnesium · neutral · Facebook ↗
      States that magnesium can affect how the body responds to a supplement.
    • 9 Oct 2026 · Vitamin D · recommends · Podcast ↗
      Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense for male fertility, even though supplementation did not improve overall semen parameters in a randomized trial.
    • 7 Oct 2026 · Vitamin D · uses · YouTube ↗
      States that currently, he is only taking vitamin C and vitamin D.
    • 7 Oct 2026 · Vitamin C · uses · YouTube ↗
      States that currently, he is only taking vitamin C and vitamin D.
    • 7 Oct 2026 · Vitamin K · recommends · YouTube ↗
      Recommends taking vitamin K2 with vitamin D to keep calcium in the bones, and suggests kids also take it for stronger bones.
    • 7 Oct 2026 · Vitamin K · recommends · YouTube ↗
      Recommends Vitamin K2, stating it supports healthy calcium metabolism.
    • 2 Oct 2026 · Trace Minerals · uses · Instagram ↗
      Uses Danger Coffee because it is third-party tested for mycotoxins and remineralized with 50+ trace minerals and electrolytes.
    • 30 Sep 2026 · Trace Minerals · uses · Facebook ↗
      Dave Asprey's company, Danger Coffee, adds essential trace minerals to the beans to provide sustained energy.
  • Ben Greenfield · Folate · recommends
    • 12 Oct 2026 · recommends · Facebook ↗
      Recommends methylfolate as an active form of folate that the body can use directly without conversion.
    • 29 Oct 2026 · Magnesium · uses · YouTube ↗
      Uses magnesium during surgery because it is neuroprotective.
    • 29 Oct 2026 · Vitamin C · recommends · YouTube ↗
      States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
    • 29 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Notes that Vitamin D is actually a hormone and recommends patients aim for levels around 40 to 50, or even 60 for fracture healing, for optimal healing, as opposed to just above 20 which is considered normal.
    • 22 Oct 2026 · Magnesium · uses · YouTube ↗
      Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
    • 15 Oct 2026 · Magnesium · recommends · Podcast ↗
      Mentions magnesium as part of a bare-minimum protocol.
    • 15 Oct 2026 · Magnesium · recommends · YouTube ↗
      Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
    • 15 Oct 2026 · Vitamin C · recommends · Podcast ↗
      Mentions vitamin C as part of a bare-minimum protocol.
    • 15 Oct 2026 · Vitamin D · recommends · Podcast ↗
      Mentions vitamin D as part of a bare-minimum protocol.
    • 15 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Advises getting vitamin D levels between 60 and 100 nanograms per milliliter as a minimum step for overall health and to slow down heart disease.
    • 15 Oct 2026 · Vitamin K · neutral · Facebook ↗
      Discusses vitamin K2, specifically the menaquinone forms, as crucial for arterial health and notes that it breaks down into MK-4 and MK-7.
    • 15 Oct 2026 · Vitamin K · uses · YouTube ↗
      Explains that gut bacteria liberate K from the diet or make the K needed, and that poor absorption of vitamin K due to bacterial imbalances is linked to heart disease.
    • 24 Sep 2026 · Vitamin C · neutral · YouTube ↗
      Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
    • 11 Sep 2026 · Trace Minerals · recommends · Facebook ↗
      States that modern diets are low on trace minerals due to processed foods and refined salt, and that these minerals are crucial for the body to process protein and amino acids.
  • Dr. Rhonda Patrick · Folate · recommends
    • 28 Sep 2026 · recommends · YouTube ↗
      Recommends ensuring adequate methyl folate intake, ideally through a prenatal vitamin, for women preparing for IVF.
    • 29 Oct 2026 · Magnesium · neutral · Facebook ↗
      Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
    • 16 Oct 2026 · Magnesium · warns · Facebook ↗
      Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
    • 5 Oct 2026 · Vitamin D · neutral · Facebook ↗
      Vitamin D supplementation was linked to a 40% lower risk of dementia in an observational study of more than 12,000 older adults.
    • 30 Sep 2026 · Vitamin D · recommends · YouTube ↗
      Mentions that vitamin D also plays a role in maintaining muscle mass.
    • 29 Sep 2026 · Magnesium · recommends · YouTube ↗
      Mentions magnesium as an important nutrient component for testosterone.
    • 28 Sep 2026 · Magnesium · warns · YouTube ↗
      Warns that some supplement companies mislead consumers by listing the total compound weight of magnesium citrate as the elemental magnesium dose, when the actual elemental magnesium content is much lower, potentially around 44-66 milligrams.
    • 28 Sep 2026 · Vitamin D · recommends · YouTube ↗
      Recommends ensuring adequate vitamin D intake for men's sperm health.
    • 24 Sep 2026 · Vitamin D · neutral · Facebook ↗
      Vitamin D and strength training alone did not, but adding them strengthened the effect on one clock, with the full combination slowing that measure by ~3.8 months.
    • 2 Sep 2026 · Magnesium · neutral · Facebook ↗
      States there is not yet strong, consistent evidence that magnesium supplementation reliably improves sleep, noting that while some meta-analyses suggest it can improve sleep quality scores, sleep efficiency, and sleep duration, individual studies are inconsistent and several have found no meaningful effect.
    • 25 Aug 2026 · Vitamin D · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 25 Aug 2026 · Vitamin K · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 25 Aug 2026 · Vitamin C · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 10 Aug 2026 · Magnesium · neutral · Facebook ↗
      States that magnesium may help modestly lower blood pressure by playing an important role in regulating vascular tone and influencing calcium signaling, with studies showing a reduction in systolic and diastolic blood pressure by 2 mmHg at a dose of around 370 mg/day for about 3 months.
  • Siim Land · Citrulline · neutral
    • 23 Sep 2026 · neutral · YouTube ↗
      States that L-citrulline can raise arginine availability and support the conventional enzymatic pathway for nitric oxide production, which does not depend on mouth bacteria.
    • 31 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Advises against taking vitamin D in the morning with other supplements because it is fat soluble and requires dietary fat for better absorption.
    • 29 Oct 2026 · Vitamin D · recommends · Instagram ↗
      Recommends taking Vitamin D with fat for better absorption.
    • 29 Oct 2026 · Vitamin C · recommends · Instagram ↗
      Recommends taking vitamin C with collagen to support joint collagen synthesis.
    • 25 Oct 2026 · Magnesium · recommends · Instagram ↗
      States that Magnesium can be a useful addition for some people for sleep.
    • 24 Oct 2026 · Vitamin D · neutral · Instagram ↗
      States that Vitamin D connects biology to light and that UVB reaching the skin enables its production.
    • 14 Oct 2026 · Vitamin C · neutral · Instagram ↗
      States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
    • 12 Oct 2026 · Magnesium · recommends · YouTube ↗
      Recommends magnesium for sleep, especially deep sleep, and suggests trying better types like Threonate, Biscinate, or Torate, referencing a study where magnesium supplementation improved deep sleep.
    • 9 Oct 2026 · Vitamin K · neutral · Instagram ↗
      Notes that Vitamin K2 helps activate proteins involved in bone mineralization and calcium regulation.
    • 8 Oct 2026 · Vitamin K · neutral · YouTube ↗
      Mentions that prunes contain vitamin K, which is a factor in their ability to help with bone density.
    • 7 Oct 2026 · Magnesium · recommends · Instagram ↗
      Recommends Magnesium for blood pressure, migraines and deficiency, based primarily on human research, especially randomized controlled trials showing measurable benefits.
    • 7 Oct 2026 · Vitamin K · recommends · Instagram ↗
      Recommends Vitamin K2 for bone health and calcium metabolism, based primarily on human research, especially randomized controlled trials showing measurable benefits.
    • 6 Oct 2026 · Magnesium · neutral · X ↗
      Lists Magnesium as one of 15 supplements backed by human studies.
    • 6 Oct 2026 · Vitamin K · neutral · X ↗
      Lists Vitamin K2 as one of 15 supplements backed by human studies.
  • Thomas DeLauer · Citrulline · recommends
    • 24 Aug 2026 · recommends · YouTube ↗
      Explains that citrulline, found in watermelon, is converted to arginine, which feeds nitric oxide synthase, amplifying one of the contraction signals that drives glucose into muscle cells, and also helps clear ammonia during exercise, preserving muscle function and accelerating recovery.
    • 28 Oct 2026 · Magnesium · uses · YouTube ↗
      Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
    • 26 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
    • 24 Oct 2026 · Magnesium · uses · YouTube ↗
      Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
    • 23 Oct 2026 · Magnesium · recommends · YouTube ↗
      Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
    • 23 Oct 2026 · Vitamin C · uses · YouTube ↗
      Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
    • 23 Oct 2026 · Vitamin D · uses · YouTube ↗
      Uses vitamin D3 in the fall and winter months when getting less sun, as it's important to supplement it then.
    • 20 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends taking a massive amount of vitamin D simultaneously with an early morning massive breakfast to help reset circadian rhythms and address hyperphagia.
    • 18 Oct 2026 · Vitamin B12 · recommends · YouTube ↗
      Recommends Vitamin B12 for mental health and mood, explaining its role in myelination and neurotransmitter production. They specifically recommend a liposomal and micellar form of methylcobalamin B12 for better absorption and to avoid toxicity.
    • 8 Oct 2026 · Magnesium · recommends · Facebook ↗
      Recommends magnesium, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
    • 8 Oct 2026 · Vitamin D · recommends · Facebook ↗
      Recommends Vitamin D, stating that it has receptors throughout the brain and deficiency can quickly impact brain and mood.
    • 6 Oct 2026 · Magnesium · neutral · YouTube ↗
      Notes that modern agricultural practices have led to soils depleted of trace minerals like magnesium, resulting in widespread magnesium deficiency.
    • 6 Oct 2026 · Vitamin D · uses · YouTube ↗
      Takes supplemental vitamin D because he is skin sensitive and from northern latitudes, limiting his UV exposure.
    • 5 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends taking vitamin D on non-liver days to ensure both nutrients get proper receptor access.
  • Andrew Huberman · Folate · recommends
    • 31 Mar 2025 · recommends · YouTube ↗
      States that B12, folate, and iron are essential to mitochondrial function and if deficient, mitochondria will not function properly, which is consistent with the mitochondrial theory of neuropsychiatric disorders.
    • 22 Oct 2026 · Magnesium · neutral · Podcast ↗
      Discusses Magnesium Threonate as a tool for falling asleep.
    • 21 Sep 2026 · Vitamin D · neutral · YouTube ↗
      Notes that most people are probably deficient in vitamin D and benefit from supplementing, but there's no point in doing it unless you're deficient for most things.
    • 7 Aug 2026 · Magnesium · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
    • 7 Aug 2026 · Vitamin D · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning for longevity.
    • 7 Aug 2026 · Vitamin K · uses · X ↗
      Takes 90 mcg of Vitamin K2 in the morning for longevity.
    • 27 Jul 2026 · Magnesium · uses · YouTube ↗
      Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
    • 20 Jul 2026 · Magnesium · uses · X ↗
      Takes 400 mg of Magnesium L-Threonate before bed for sleep.
    • 20 Jul 2026 · Magnesium · recommends · YouTube ↗
      Confirms that magnesium is absolutely important for cognitive function, noting studies show those with lower magnesium intakes tend to perform less well on cognitive function tests, and it's related to brain changes over time and dementia risk.
    • 20 Jul 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 20 Jul 2026 · Vitamin D · recommends · YouTube ↗
      States that Vitamin D is one of the critical nutrients with the best evidence for cognitive function and reducing the risk of dementia.
    • 13 Jul 2026 · Magnesium · uses · X ↗
      Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
    • 13 Jul 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning.
    • 13 Jul 2026 · Vitamin K · uses · X ↗
      Takes 90 mcg of Vitamin K2 in the morning.
  • Peter Attia · Folate · recommends
    • 19 Aug 2024 · recommends · YouTube ↗
      Highlights folate supplementation as a significant practical progress in nutrition science, which has radically reduced spinabifida.
    • 1 Jun 2026 · Magnesium · neutral · Podcast ↗
      Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
    • 4 Jan 2026 · Magnesium · recommends · YouTube ↗
      Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
    • 4 Jan 2026 · Vitamin D · uses · YouTube ↗
      Lists vitamin D as one of her staple supplements.
    • 16 Nov 2025 · Vitamin D · neutral · YouTube ↗
      Notes that several studies show patients taking vitamin D can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
    • 15 Sep 2025 · Magnesium · recommends · Podcast ↗
      Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
    • 6 Aug 2025 · Vitamin D · neutral · YouTube ↗
      States that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin D for both sexes.
    • 3 Aug 2025 · Vitamin D · neutral · YouTube ↗
      Uses vitamin D as an example of how people might dismiss its efficacy due to failed clinical trials that didn't adjust the dose or measure levels.
    • 20 Jul 2025 · Vitamin D · neutral · YouTube ↗
      In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin D for both sexes.
    • 10 Jul 2025 · Vitamin D · neutral · YouTube ↗
      Suggests that supplementing with lots of vitamin D might help overcome the negative effects of phenytoin on bone health by improving calcium absorption, though he is unaware of studies on this.
    • 9 Jul 2025 · Magnesium · recommends · YouTube ↗
      Recommends magnesium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 300 to 500 milligrams as a minimum, and personally aims for about a gram of supplemental magnesium.
    • 9 Jul 2025 · Vitamin D · recommends · YouTube ↗
      Recommends Vitamin D3 as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 800 to 1,000 IU, which can be obtained through sunlight or supplementation.
    • 6 Jul 2025 · Magnesium · recommends · YouTube ↗
      Recommends magnesium for optimizing bone mineral density, suggesting a daily intake of 300 to 500 milligrams as a minimum, but personally aims for about a gram.
    • 6 Jul 2025 · Vitamin D · neutral · YouTube ↗
      Suggests that supplementing with lots of vitamin D might overcome the negative effects of phenytoin on bone health by counteracting increased catabolism of vitamin D and subsequent decreased calcium absorption.
  • Bryan Johnson · Vitamin K · uses
    • 22 Oct 2026 · uses · X ↗
      Takes 90 mcg of Vitamin K2 in the morning for general health.
    • 22 Oct 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 22 Oct 2026 · Magnesium · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
    • 15 Aug 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 15 Aug 2026 · Magnesium · uses · X ↗
      Takes 400 mg of Magnesium L-Threonate before bed for sleep.
    • 3 Jul 2026 · Vitamin D · neutral · X ↗
      Mentions that the sunlight assessment claims low vitamin D levels cause the immune system to misfire, and notes that their vitamin D has been measured.
    • 4 May 2026 · uses · X ↗
      Takes 100 mcg of Vitamin K2 in the morning for longevity.
    • 4 May 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for longevity.
    • 4 May 2026 · Magnesium · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
    • 2 May 2026 · uses · X ↗
      He takes 100 mcg of Vitamin K2 in the morning for general health.
    • 2 May 2026 · Vitamin D · uses · X ↗
      He takes 5000 IU of Vitamin D3 in the morning for general health.
    • 2 May 2026 · Magnesium · uses · X ↗
      He takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
    • 21 Apr 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 21 Apr 2026 · Magnesium · uses · X ↗
      Takes 400 mg of Magnesium L-Threonate before bed for sleep.

RAL Summary

Members OnlyTier 4 for Circulation

Tier 4 because the main ingredients have mixed study results: L-arginine trials disagree [PMID:17592080, PMID:12419572], while citrulline and folate show some benefit [PMID:41323997, PMID:17420345]. No reviews were counted to confirm the effect.

Take 2 servings a day to match the dose that worked in the studies.

  • Emerging: not enough evidence to rank higher yet.

Where the evidence disagrees: 106 of the 350 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Cardiovascular system

Combine with: For circulatory support, L-Arginine pairs well with L-Citrulline, which raises arginine levels more effectively and sustains nitric oxide production. Beet root extract or other nitrate sources, CoQ10, magnesium, and omega-3 fish oil further support vascular function and healthy blood pressure. Vitamin C and additional polyphenols such as pycnogenol or resveratrol help protect nitric oxide from oxidation. For fast heartburn relief, a separate product is more appropriate, such as calcium carbonate, magnesium hydroxide, or an alginate (sodium alginate) formula. Take L-Arginine with food if it upsets the stomach, and consult a healthcare provider if you take meds, nitrates, or erectile dysfunction drugs, or have frequent heartburn.

Possible side effects: In one small study, a few days of L-arginine worsened small blood vessel function in older adults, and citrulline was linked to higher blood pressure in pregnant women with preeclampsia. Reviewers mainly mention an artificial, drink-mix-like flavor.

Supplement Facts

Total Carbohydrates 4 g · Vitamin C 60 mg · Vitamin D3 2500 IU
Supplement Facts
Serving Size 12.7 Gram(s)
Servings Per Container 30
Amount Per Serving% Daily Value
Calories35
Total Carbohydrates4 g
Vitamin C60 mg
Vitamin D32,500 IU
Vitamin K20 mcg
Vitamin B62 mg
Folate400 mcg
Vitamin B126 mcg
Magnesium20 mg
L-Arginine5,110 mg†
L-Citrulline1,010 mg†
Red Wine extract100 mg†
AstraGin50 mg†
Proprietary Blend of 72 Trace Minerals100 mg†
† Daily Value not established.

Other ingredients: Citric Acid, Xylitol, SWETA, Calcium Silicate, Natural flavor, Natural colors.

Directions: Directions: Mix 1 scoop L-Arginine Plus powder with 4-8 oz water. Stir to dissolve. If water is very cold, mixture may take longer to dissolve. Take between meals or on an empty stomach.

Barcode (UPC) 852433006018 · Label source: NIH label database · Report a label change

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Graded November 8, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.