GNC Herbal Plus Chasteberry (Vitex) 500 mg Review
This GNC product is a whole herb chasteberry supplement sold under the GNC brand on Amazon Saudi Arabia. The listing identifies it as a Food Supplement and a dietary supplement in capsule form, with each bottle holding 100 capsules and a listed serving size of 500 mg. The page states the product is aimed at a women's targeted group. The ingredient line reads Chastberry Fruit Powder (Vitex agnus-castus) 500mg, and the directions tell the user to take one capsule daily as a dietary supplement. The item details table lists the brand as GNC, the manufacturer as GNC, the container type as bottle, the dosage form as capsule, and the manufacturer part number as 187913. The ASIN is B081V2X8G2 and the item weight is listed as 0.5 grams with a single item per package and a unit count of 100. The product description section on the page contains only the words Dietary Supplement, so no further marketing copy is provided. The page currently shows the product as unavailable, stating that Amazon does not know when or if it will be back in stock. There is no featured offer and no price is displayed in the price section, with only a link to other sellers. The page also shows a return policy notice and a secure transaction notice, along with general Amazon navigation and footer content that is not specific to this product. Several safety and manufacturer information panels failed to load on the page, so no responsible person or manufacturer details beyond the brand name are available from this capture. No barcode, UPC, EAN or GTIN is printed in the text captured from this listing. The page also includes a note that a browser extension blocked a third party advertising domain, which does not affect the product information shown. Overall the listing confirms the brand, the chasteberry ingredient at 500 mg per capsule, and the capsule form, but gives no price, no reviews and no further descriptive marketing text for the product.
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Study, Trial or Testing Result Summary
Members Only38 human studies · 32 improved
Chasteberry has good evidence for easing premenstrual symptoms. Pooling three placebo-controlled trials in 520 women, those taking chasteberry were 2.57 times more likely to have their premenstrual symptoms go into remission [1]. In a trial of 170 women over three cycles, 52% on chasteberry had their symptoms cut by at least half, compared with 24% on placebo [2]. A trial of 162 women found 20 mg a day of an extract worked better than placebo, while 30 mg added nothing more [3]. Another trial of 217 women saw benefit at 40 mg a day with no serious side effects [4]. Pooling six trials in 718 women, chasteberry also eased cyclic breast pain over about three months [5]. One larger analysis of 14 trials warned that the studies were often biased and varied widely, so the benefit is probably overstated [6]. The studies used concentrated extracts at 20 to 40 mg a day. This product is 500 mg of whole fruit powder, so its strength cannot be directly compared with the doses that were studied [3]. Animal and cell studies are never counted.
See all 38 studies →Hide the studies
- Pooling six placebo-controlled trials of 718 women with cyclic breast pain, chasteberry (typically 20-40 mg a day for about 3 months) eased breast pain more than placebo, with only mild side effects.Vitex Agnus-Castus for the Treatment of Cyclic Mastalgia: A Systematic Review and Meta-Analysis.
- Pooling three well-described placebo-controlled trials of 520 women with premenstrual syndrome, women taking chasteberry extracts were 2.57 times more likely to have their symptoms go into remission than those taking placebo.Vitex agnus-castus in premenstrual syndrome: A meta-analysis of double-blind randomised controlled trials.
- Across 14 trials in women with premenstrual syndrome, chasteberry showed a large benefit over placebo, but the studies had high risk of bias, very different results and likely publication bias, so the effect is probably overestimated.The treatment of premenstrual syndrome with preparations of Vitex agnus castus: a systematic review and meta-analysis.
- In four trials with about 500 women, chasteberry consistently eased premenstrual symptoms better than placebo, with no major health risks reported.Herbal treatments for alleviating premenstrual symptoms: a systematic review.
- In this review of trials of natural products for premenstrual syndrome, the data suggested chasteberry may be effective, though only calcium had good quality evidence.Herbs, vitamins and minerals in the treatment of premenstrual syndrome: a systematic review.
- A broad review of menopausal symptom treatments covered agnus castus among many options, but the summary gives no results specific to chasteberry.Menopausal symptoms.
- An earlier edition of the broad menopausal symptom review listed agnus castus among the treatments examined, but the summary gives no results specific to chasteberry.Menopausal symptoms.
- A review of randomized trials in menopausal women found that chasteberry (Agnus castus) combined with St John's wort showed no significant difference in climacteric complaints, and chasteberry showed no better effect than placebo.Efficacy of Cimicifuga racemosa, Hypericum perforatum and Agnus castus in the treatment of climacteric complaints: a sys…
- In 12 randomized trials, chasteberry beat placebo in most premenstrual syndrome trials and lowered prolactin in women with latent high prolactin, was mixed against a med for severe premenstrual mood disorder, and caused only mild side effects.Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials.
- This review of acupuncture and herbal trials, including chasteberry, found limited evidence that herbal treatments improved premenstrual symptoms, with no serious side effects.Effects and treatment methods of acupuncture and herbal medicine for premenstrual syndrome/premenstrual dysphoric disord…
- All eight randomized trials reviewed found chasteberry helpful for premenstrual syndrome or premenstrual dysphoric disorder, and it was generally well tolerated, though the studies used different extracts and measures.Vitex agnus castus for premenstrual syndrome and premenstrual dysphoric disorder: a systematic review.
- A review of herbal treatments for polycystic ovary syndrome reported that Vitex agnus-castus reduced hirsutism by lowering testosterone and androgen levels, though the review did not give study sizes or doses.Polycystic ovaries and herbal remedies: A systematic review.
- In 217 Chinese women with moderate to severe premenstrual syndrome, 40 mg of chasteberry extract over three menstrual cycles lowered symptom scores more than placebo, with no serious adverse events.Treatment for premenstrual syndrome with Vitex agnus castus: A prospective, randomized, multi-center placebo controlled …
- In 170 women with premenstrual syndrome taking one agnus castus extract tablet daily for three cycles, 52% of the 86 women on the extract responded with at least a 50% symptom reduction, compared with 24% on placebo.Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo controlled stu…
- In 162 women with premenstrual syndrome taking 20 mg daily of the chaste tree extract Ze 440 for three menstrual cycles, symptom scores improved more than with placebo, while 8 mg was less effective and 30 mg added no further benefit.Dose-dependent efficacy of the Vitex agnus castus extract Ze 440 in patients suffering from premenstrual syndrome.
- In a randomized placebo-controlled trial of 128 women with premenstrual syndrome, Vitex agnus extract drops taken for six cycles reduced symptoms such as headache, anger, irritability and bloating more than placebo, with good tolerance.Therapeutic effect of Vitex agnus castus in patients with premenstrual syndrome.
- In a three-group randomized trial of 108 university students with premenstrual syndrome, one daily Vitagnus capsule over two cycles significantly reduced symptoms, and combining it with soy worked better for mood and total symptoms than either alone.Comparison of the Effects of Vitagnus, Soy, and Vitagnus-soy Capsules on Premenstrual Syndrome in University Students: A…
- In 101 post-menopausal women over 12 weeks, a supplement combining chasteberry with black cohosh, soy and evening primrose oil reduced hot flushes, sleep problems, low mood and irritability more than placebo, and lowered C-reactive protein, with no side effects reported.Efficacy and Safety of Nutraceutical on Menopausal Symptoms in Post-Menopausal Women: A Randomized, Double-Blind, Placeb…
- In 100 late-perimenopausal or postmenopausal women with hot flushes, a twice-daily chaste tree and St. John's wort combination over 16 weeks was not better than placebo for hot flushes, mood, or quality of life.Hypericum perforatum with Vitex agnus-castus in menopausal symptoms: a randomized, controlled trial.
- In a randomized placebo-controlled trial of 67 Chinese women with moderate to severe premenstrual syndrome, one daily tablet of Vitex agnus castus extract reduced symptoms more than placebo by the third cycle, especially negative mood and water retention.Treatment of moderate to severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women.
- In 67 Chinese women with moderate-to-severe premenstrual syndrome, the chaste tree extract BNO 1095 over three cycles improved all 17 tracked symptoms more than placebo, except lower abdominal cramping.Evaluating therapeutic effect in symptoms of moderate-to-severe premenstrual syndrome with Vitex agnus castus (BNO 1095)…
- In a double-blind trial of 60 postmenopausal women aged 50 to 70, eight weeks of daily Vitagnus drops improved sexual function scores compared with placebo, with significant differences appearing by weeks six and eight.Vitagnus an estrogen-riched herbal remedy used in sexual dysfunction: A randomized clinical trial.
- In a double-blind trial of 52 menopausal women, eight weeks of Vitex agnus-castus extract lowered total menopausal symptoms, anxiety and hot flashes more than placebo, but did not change somatic complaints, depression or sexual dysfunction.Comparison of Vitex agnus-castus Extracts with Placebo in Reducing Menopausal Symptoms: A Randomized Double-Blind Study.
- In 50 pre- and postmenopausal women taking a multi-herb formula that includes chaste tree berry twice daily for 3 months, hot flushes fell by 73% and night sweats by 69%, with better sleep and greater relief than placebo, though the chaste tree dose was not reported.Phyto-Female Complex for the relief of hot flushes, night sweats and quality of sleep: randomized, controlled, double-bl…
- In 46 menopausal women with hot flashes over 8 weeks, adding a chasteberry and black seed capsule to citalopram reduced vasomotor, physical and psychosocial symptoms more than citalopram with placebo.Effects of a combination of Nigella sativa and Vitex agnus-castus with citalopram on healthy menopausal women with hot f…
- In a 42-woman placebo-controlled trial lasting 3 months, a supplement containing chasteberry improved mood and antioxidant status within the group, but no differences appeared compared with placebo, suggesting a placebo effect.Effects of the PREMEN-CALM® in the Management of the Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controll…
- In a randomized trial of 41 women with premenstrual dysphoric disorder over two months, 57.9% responded to Vitex agnus castus extract, similar to the 68.4% response with a med; the extract mainly eased physical symptoms, while a med worked better on mood.Read the study on PubMed (12672170) →
- In a small subgroup of 14 late-perimenopausal women, a twice-daily tablet combining chaste tree berry with St. John's wort reduced premenstrual-type symptoms over 16 weeks, with better results than placebo on total score, depression, and cravings.Effects of a combination of Hypericum perforatum and Vitex agnus-castus on PMS-like symptoms in late-perimenopausal wome…
- In a randomized study of women with premenstrual dysphoric disorder, chaste tree treatment was reported to be effective with no side effects, and it was compared with a med; the sample size and duration were not stated in the abstract.[Psychic aspects of the premenstrual dysphoric disorders. New therapeutic strategies: our experience with Vitex agnus ca…
- In an uncontrolled open study of 1634 women with premenstrual syndrome taking a chaste tree fruit extract for three cycles, 93% reported fewer symptoms or no symptoms, and 94% rated tolerance as good or very good.Treatment of premenstrual syndrome with a phytopharmaceutical formulation containing Vitex agnus castus.
- In an open-label study of 100 migraine-prone women with premenstrual syndrome, 40 mg daily of Vitex agnus-castus for 3 months dramatically reduced premenstrual symptoms in 66 women, with no notable side effects; there was no placebo group.Use of Vitex agnus-castus in migrainous women with premenstrual syndrome: an open-label clinical observation.
- In an open-label study of 69 Japanese women with premenstrual syndrome, 20 mg daily of Vitex agnus-castus extract for three cycles lowered symptom scores each cycle, and 91% were responders by the third cycle; there was no placebo group.Efficacy and safety of Vitex agnus-castus extract for treatment of premenstrual syndrome in Japanese patients: a prospec…
- In an open-label real-world study of 59 women with premenstrual syndrome, 90 days of Ezedayz tablets containing Vitex agnus-castus, vitamin B6 and magnesium improved pain and quality of life more than standard care alone, with no serious side effects reported.Efficacy and Tolerability Evaluation of a Nutraceutical Composition Containing Vitex agnus-castus Extract (EVX40™), Pyri…
- In a multicentre single-group study of 43 women with premenstrual syndrome, 20 mg daily of Vitex agnus castus extract Ze 440 for three cycles cut symptom scores by 42.5%, and 20 of 43 women had at least a 50% reduction; there was no placebo group.Efficacy of Vitex agnus castus L. extract Ze 440 in patients with pre-menstrual syndrome (PMS).
- In a retrospective study of 1700 women with menstrual cycle problems, three months of Vitex agnus-castus products (Cyclodynon or Mastodynon) reduced irregular cycles and breast tenderness, and most women reported less bleeding and menstrual pain, with improvements varying by condition.Use of Vitex agnus-castus in patients with menstrual cycle disorders: a single-center retrospective longitudinal cohort …
- In a survey of 1658 German women using herbal products for gynaecological complaints, Vitex agnus-castus was the most used product for menstrual complaints, and users rated its effectiveness and tolerability as very good.Trends and Patterns for the Use of Herbal Medicinal Products for Gynaecological Ailments.
- In 180 postmenopausal women followed for 12 months, a combination of agnus-castus and magnolia extracts with soy isoflavones and lactobacilli reduced hot flashes and improved sleep quality more than isoflavones alone, with no adverse events and no change in breast density, uterine lining or liver function.Adding Agnus Castus and Magnolia to Soy Isoflavones Relieves Sleep Disturbances Besides Postmenopausal Vasomotor Symptom…
- In a small uncontrolled practitioner-supervised trial of 52 women, a Vitex agnus castus essential oil gave strong relief from common menopausal symptoms, with some contraindications identified.Vitex agnus castus essential oil and menopausal balance: a research update [Complementary Therapies in Nursing and Midwi…
Review Totals and Summary
Members OnlyWhat buyers say
Feedback on this exact GNC capsule is thin, so the themes come from broader chasteberry/Vitex user reviews, which include a few GNC users. WebMD's pooled Vitex reviews show a positive overall leaning, with an average around 4.1 out of 5. The main praise is for PMS relief. Users describe reduced breast tenderness, less depression and irritability, and calmer premenstrual weeks. One reviewer who took about 400 mg daily for two months said it helped with breast tenderness and low mood. Several women say they chose it after reading other people's positive reviews. Some report cycle regulation, including one who hadn't had a period for months and began tracking ovulation after starting it. Others say it helps only after a few months, so patience is a recurring theme. Many people also like having a single-ingredient, free-from-allergens herbal option instead of a hormonal prescription. Complaints are more varied and often tied to side effects or unexpected hormonal effects. A few users, including GNC users at 500–1000 mg a day, describe unwanted changes. One man reported that it suppressed his libido, along with intermittent genital discomfort and numbness or cramping in the feet and legs. Another man said he used it on purpose to curb libido and that it worked quickly. Some users believe it caused weight gain. Others mention irregular bleeding or changed cycles, or that it didn't work at all for their symptoms. People worry about dosing: many take 1000 mg a day, which is twice the label serving for this product, and few know whether that is appropriate. Practical comments centre on the lack of standardization. Because this is a whole-herb powder, people can't tell how strong it is compared with extract products. Pill size and taste rarely come up. The overall picture is of a supplement that many women find helpful for PMS-type symptoms if they give it time, that can disrupt hormones in some people, and that has little GNC-specific feedback online.
Biohacker Summary
Members Only5 of 10 recommend it
Four of the ten panelists spoke about chasteberry, the main ingredient, and all four recommend it. The most common reason is hormone support for women: premenstrual symptoms, progesterone, a regular menstrual cycle, hot flashes, and fertility and egg quality. One panelist also suggests it for getting estrogen up, taking it alongside DHEA, and another says it helps balance hormones in both men and women. No one gave a dose or a preferred form, and no one reported a caution or said they stopped taking it.
See all 4 biohackers →Hide the biohackers
Dr. Mark Hyman · Chasteberry · recommends
- Recommends chasteberry as a supplement shown effective in studies of over 5,000 women for PMS.
- Recommends Chasteberry as great for PMS.
- Uses Chasteberry (Vitex), an herb, to help promote the body to make more progesterone.
- Lists Chasteberry Plus® PMS Relief by Metagenics as a product available.
Thomas DeLauer · Chasteberry · recommends
- Recommends Chasteberry as a good compound for getting estrogen levels up, suggesting it be taken alongside DHEA.
Dr. Eric Berg · Chasteberry · recommends
- Recommends chasteberry, an herb known to increase fertility, decrease prolactin levels, increase cervical mucus to support sperm, decrease PCOS, support follicle development, and improve egg quality.
Ben Greenfield · Chasteberry · recommends
- Ben recommends Chasteberry as a natural remedy for hot flashes.
- Recommends chasteberry as an herb that is good for balancing hormones in both men and women.
- Ben recommends chasteberry for progesterone support for females looking to lose body fat fast.
- Ben recommends Chasteberry for lowering sperm count.
- Ben recommends Chasteberry to help regulate the menstrual cycle.
- He recommends Chasteberry for low progesterone.
- Lists Chasteberry as a supplement for low progesterone.
- Discusses chasteberry as a natural medicine recommendation to jumpstart periods and address menstrual irregularity, especially after stopping birth control. He explains it suppresses prolactin release and is a natural source of progesterone, helping to normalize the progesterone to estrogen ratio, and may also help with peri-menopause symptoms. He warns against taking it for more than 6-8 months and combining it with neurotransmitter-related medications.
RAL Summary
Members OnlyTier 4 for Hormone Balance for Women
The review summary is drawn mostly from pooled reviews of chasteberry products in general, such as WebMD's Vitex reviews, not from reviews of this GNC capsule, and no reviews of this product were counted. Its reviews are set aside, so it is graded on its studies alone. Human studies support Chasteberry (32 of 38 human studies showed an improvement), but there are not yet enough reviews to confirm it (0).
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 3 of the 38 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Reproductive system, Endocrine system
Combine with: For its actual purpose of women's hormonal balance, Vitex pairs well with magnesium glycinate (PMS cramping, mood and sleep), vitamin B6 as pyridoxal-5-phosphate (premenstrual mood and progesterone support), and omega-3 fish oil (menstrual discomfort and inflammation). Calcium with vitamin D, evening primrose oil, or DIM may also be considered for cyclical symptoms. Avoid combining it with hormonal contraceptives, dopamine-affecting medications or fertility treatments without clinician guidance. For the stated anti-aging and DNA repair goal, choose different products such as NMN or NR, resveratrol or pterostilbene, CoQ10 or ubiquinol, quercetin, fisetin, and alpha-lipoic acid, ideally with a healthcare provider's input.
Possible side effects: Studies reported only mild side effects and no serious adverse events. General chasteberry user reviews, not specific to this product, mention lowered libido, weight gain and changed or irregular bleeding in some people.
Supplement Facts
Chasteberry fruit powder 500 mg
| Chasteberry fruit powder | 500 mg | † |
Other ingredients: Microcrystalline Cellulose, Vegetable Cellulose Capsule.
Directions: Directions: As a dietary supplement, take one capsule daily. Discontinue use two weeks prior to surgery.
Barcode (UPC) 048107128623 · Label source: NIH label database · Report a label change
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Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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