Healthy Origins Vitamin D3 1,000 IU 25 mcg Review
Healthy Origins Vitamin D3 1,000 IU 25 mcg is listed on the Dietary Supplement Label Database as a Vitamin product in softgel capsule form, with a net content of 90 softgel(s). The label lists one softgel as the serving size, with 90 servings per container. Each serving provides Vitamin D3 (as from Lanolin), also listed under the alternate name cholecalciferol, with a note of 1000 IU and 25 mcg, which the label shows as 125% of the Daily Value. Percent Daily Values are based on a 2,000 calorie diet, and the Daily Value figures are for adults and children 4 or more years of age. The label describes the formula as a key nutrient manufactured in a highly absorbable softgel. It explains that vitamin D3 can be synthesized in the body from sunlight, but only a small amount can be obtained from food. It states that the winter season and many sunblock products inhibit the body's ability to produce optimal levels of vitamin D, so supplementation becomes more necessary to ensure an adequate supply. The label also says the product supports bone health and immune function. The other ingredients listed are cold-pressed olive oil, kosher gelatin, glycerin, and purified water. The label states the product is non GMO and is not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, peanut or tree nut derived ingredients. It says there are no preservatives, artificial colors or artificial flavors. The seal reads 3rd party tested, the product is listed as gluten free and dairy free, and the label notes it is manufactured in a cGMP facility. The suggested directions for adults are to take one softgel daily, preferably with a meal, or as directed by a physician. The label advises keeping the product out of reach of children, and says to consult a physician before use if you are pregnant, nursing, taking medication or have a medical condition. It recommends storing the product in a cool, dry place. The label is distributed by Healthy Origins of Pittsburgh, PA, USA, and states the brand has been in business since 1996. The FDA statement of identity classifies the product as a dietary supplement, and the label notes that the statements have not been evaluated by the Food and Drug Administration and that the product is not intended to diagnose, treat, cure or prevent any disease. The data was sourced from NIH in May 2022, and the label was entered into the database on 19 May 2022 under DSLD ID 268973.
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Study, Trial or Testing Result Summary
Members Only13 human studies · 2 improved
Each softgel gives 1,000 international units of vitamin D3, a full dose that is above the 700 to 800 units a day that helped in older adults. The studies on vitamin D for bone health disagree. A review of trials in older adults found that 700 to 800 units a day cut hip fractures by about a quarter and other non-spine fractures by about a fifth, while 400 units a day did not help [1]. A trial found that children whose mothers took 1,000 units a day during pregnancy had denser bones at ages 6 to 7 [2]. Other reviews found no clear drop in fractures. Across nine studies, vitamin D3 did not significantly reduce fractures compared with placebo or calcium alone [3]. In women after menopause with thinning bones, calcium plus vitamin D slightly improved pelvic bone density but not spine or hip density, and did not reduce fractures [4]. In women after menopause without thinning bones, vitamin D raised blood levels and improved some bone turnover measures, but a fracture benefit could not be confirmed [5]. In kidney transplant patients, vitamin D-like drugs, not plain vitamin D3, improved bone density without fewer fractures [6]. Animal and cell studies are never counted.
See all 13 studies →Hide the studies
- In 11 trials of 43,869 postmenopausal women with osteoporosis, calcium plus vitamin D modestly improved pelvic bone density but not spine, neck of femur or total hip density, and did not reduce fractures.The effects of combined calcium and vitamin D supplementation on bone mineral density and fracture risk in postmenopausa…
- This review of smartphone apps for osteoporosis self-management did not test vitamin D supplements and found no significant effect on vitamin D intake.Digital Health Technologies for Long-term Self-management of Osteoporosis: Systematic Review and Meta-analysis.
- In trials of older adults, 700 to 800 IU a day of vitamin D cut hip fracture risk by 26% and other nonvertebral fractures by 23%, while 400 IU a day gave no significant benefit.Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials.
- Across nine studies, vitamin D3 did not significantly reduce nonvertebral or vertebral fractures versus placebo or calcium alone, with only a borderline trend toward fewer falls.The effect of cholecalciferol (vitamin D3) on the risk of fall and fracture: a meta-analysis.
- In 23 trials of 1,209 kidney transplant recipients, vitamin D analogues (2 trials, 51 patients) improved lumbar spine and femoral neck bone density versus no treatment, but no trial showed fewer fractures.Interventions for preventing bone disease in kidney transplant recipients: a systematic review of randomized controlled …
- In 18 small trials of 576 children with chronic kidney disease, vitamin D preparations lowered parathyroid hormone levels, but there were few data on growth or bone deformities and no clear differences between preparations.Interventions for metabolic bone disease in children with chronic kidney disease.
- One small trial of 39 people with sickle cell disease found vitamin D3 for six weeks raised blood vitamin D and reduced pain days versus placebo, but no bone outcomes were reported and the evidence was low quality.Vitamin D supplementation for sickle cell disease.
- In nine trials of postmenopausal women without osteoporosis, vitamin D raised blood vitamin D and improved some bone remodeling measures, but only one study found fewer fractures, so a fracture benefit could not be confirmed.Supplementation of vitamin D isolated or calcium-associated with bone remodeling and fracture risk in postmenopausal wom…
- In 500 elderly women with Alzheimer disease who all took 1000 IU of vitamin D2 plus calcium, adding risedronate for 18 months raised bone density 4.1% and cut hip fracture risk compared with placebo, but vitamin D itself was not tested alone and the paper was retracted.The prevention of hip fracture with risedronate and ergocalciferol plus calcium supplementation in elderly women with Al…
- Children whose mothers took 1000 IU of vitamin D3 daily during pregnancy had higher whole-body bone mineral content and density at ages 6-7 than children whose mothers took placebo.Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled…
- In 242 elderly men with Parkinson disease who all took 1000 IU of vitamin D2, adding risedronate for 2 years raised bone density, but vitamin D was not compared against placebo and the paper was retracted.Risedronate and ergocalciferol prevent hip fracture in elderly men with Parkinson disease.
- In Tuscany, Italy, most people who broke a hip from 2011 to 2015 were not taking vitamin D supplements, and only 30-35% were on cholecalciferol one year after the fracture; no bone outcome was measured against a comparison group.The use of cholecalciferol in patients with hip fracture.
- In a 2-year cross-sectional study of 116 pre- and post-menopausal obese and non-obese women, daily vitamin D and calcium intake was low and osteoporosis was less common in obese women, though blood vitamin D levels were within normal range.Dietary Pattern and Bone Health in Pre and Post-menopausal Obese Women.
Review Totals and Summary
Members Only477 reviews · 91% positive
Shoppers rate this vitamin D3 softgel highly, with about 351 ratings across the stores that sell it and most reviews giving 4 or 5 stars. Buyers mainly praise the quality, price and large quantity, and a few note that the softgels are very hard. Reviews of other forms of the product were left out, and these notes cover the softgels only. **What buyers say it did for them:** Few describe measurable results. Some say they bought it because of a deficiency or a doctor's advice, and that it "works great." One buyer wrote, "I have a vitamin D deficiency so I bought this to help assist." Another said it was "recommended by my doctor 12 years ago and still the best in the market." Several say they have taken it for years, and one calls it their "staple for years now." **What buyers complain about:** Complaints are few. One 3-star reviewer titled the review "Beware the %Daily Value!" and said their doctor had found their levels "VERY low." The review is cut off, so the rest of the complaint is unclear. A 4-star reviewer found the softgels hard: "they are like little rocks. Can't even squeeze them." One reviewer said the extra cost of the product and shipping to Canada, about 30% more, made it not inexpensive, though they still consider it "well worth it." Another warned that fat-soluble vitamins can be dangerous and that sun exposure is better, while saying "Nothing wrong with the supplement." **Taste, smell, pill size and form:** Reviewers did not mention taste or smell. One calls the softgels "small softgels" that are "Easy to swallow." Another finds them very hard for a softgel but still takes them daily. One buyer likes that they "don't contain harmful oils" and says they are "much better than other brands." **Value for money:** Value is a strong point. Reviewers write "Very good price and product" and "Fairly priced and quickly shipped." Another says the brand offers "good quality and dosage for fair price." The large quantity is welcomed, including the 360-count bottle that one reviewer describes as a one-year supply. The 4-star reviewer says that for the price and quantity they "would probably purchase them again." The Canadian buyer is the exception, as the extra shipping cost made it dearer. **Who it seems to suit and who it did not:** The reviews suggest it suits people who take vitamin D daily over the long term, including those told by a doctor to take it for low levels. People also buy it for family members, such as a husband, a mother, or a friend's children when a doctor prescribed it. One buyer thought of it for winter, when there is less time in the sun. It suited less well the buyer who found the softgels very hard, the one who was disappointed over the daily value, and the one who prefers sunshine to supplements. Several others praise fast shipping and timely delivery, but that concerns the seller more than the product.
Biohacker Summary
Members Only7 of 10 recommend it
Most of the panel recommends or uses vitamin D, and all ten spoke about it. People take it for immune health, brain and mood, bone strength, muscle, and general health or longevity, and several use it mainly in fall and winter when sun is limited. Three of them take 5000 IU of D3 in the morning, one pushes for at least 10,000 IU a day, and several say to test blood levels and aim for a higher range than the usual cutoff. Many pair it with vitamin K2 (and one adds magnesium), and one advises taking it with dietary fat for better absorption. One panelist says there is little point in supplementing unless you are deficient, though most people probably are, and nobody said they stopped taking it.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Vitamin D · warns
- Dr. Berg warns that the recommended daily intake for vitamin D is based on a massive error and that the actual necessary amount is closer to 8,895 IU, with millions remaining deficient.
- Recommends getting vitamin D levels tested to ensure they are between 50 and 70, as vitamin D is intimately involved in regulating prostate size.
- Recommends taking at least 10,000 IUs of vitamin D3 every single day in the winter, stating it is the most important vitamin to lower cancer risk.
- Recommends vitamin D to support the immune system, aiming for blood levels between 80 to 100 ng per ml.
- Recommends taking no less than 10,000 IU's of vitamin D3 for osteoporosis, alongside magnesium and K2.
- Recommends increasing vitamin D to restore balance and support healthy blood pressure.
- States that a lack of vitamin D can potentially cause achy bones or crashing mood.
- States that vitamin D is intimately involved in the immune system and recommends taking at least 10,000 IUs each day.
- States that taking high doses of vitamin D3 for 14 days can improve mood, sleep, low back pain, skin issues, and blood pressure, as well as act as a natural anti-inflammatory and reduce susceptibility to sickness.
- Mentions that grass-fed liver has vitamin D.
Dave Asprey · Vitamin D · uses
- Takes Vitamin DAKE from Suppgrade Labs.
- Suggests that vitamin D supports brain health, muscle function, and focus.
- Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense for male fertility, even though supplementation did not improve overall semen parameters in a randomized trial.
- States that currently, he is only taking vitamin C and vitamin D.
- Recommends vitamin D, noting it's actually a hormone and that most people are deficient, even those who take it, because they don't take enough.
- States that most people on the spectrum are low in vitamin D and need more of it, mentioning his own product, Vitam DAKNE, which contains real vitamin A.
- Dave Asprey recommends Vitamin D3 with K2, explaining D3 is a hormone made from sunlight and K2 directs calcium into bones, not arteries, highlighting its low cost, widespread deficiency, and the ability to test its effectiveness.
- Recommends Vitamin D as one of the most important supplements for overall health.
- Takes Vitamin DAKE from Suppgrade Labs because D3, A, K2, and E work together.
- Mentions taking vitamin D in the morning, comparing it to the daily dosing of testosterone.
Siim Land · Vitamin D · recommends
- Advises against taking vitamin D in the morning with other supplements because it is fat soluble and requires dietary fat for better absorption.
- Recommends taking Vitamin D with fat for better absorption.
- States that Vitamin D connects biology to light and that UVB reaching the skin enables its production.
- Thinks vitamin D has some of the strongest evidence and is worth considering.
- Notes that Vitamin K2 pairs well with vitamin D by regulating calcium and bone mineralization.
- Recommends taking vitamin D supplements with some fat to maximize its absorption, suggesting with food or a teaspoon of olive oil.
- Notes that taking vitamin D3 with a fat-containing meal resulted in 32% higher peak blood vitamin D levels.
- Recommends taking Vitamin D in the morning or at lunch with fat.
- Notes that Boron improves vitamin D.
- Recommends Vitamin D because microglia contain Vitamin D receptors, and Vitamin D helps keep the immune system properly regulated, with low levels associated with greater neuroinflammation and a higher risk of autoimmune conditions.
Ben Greenfield · Vitamin D · recommends
- Notes that Vitamin D is actually a hormone and recommends patients aim for levels around 40 to 50, or even 60 for fracture healing, for optimal healing, as opposed to just above 20 which is considered normal.
- Mentions vitamin D as part of a bare-minimum protocol.
- Advises getting vitamin D levels between 60 and 100 nanograms per milliliter as a minimum step for overall health and to slow down heart disease.
- Has been taking Vitamin D3 K2 for over a decade.
- Notes that sunlight influences more than just vitamin D production.
- Recommends keeping vitamin D levels high, suggesting that a supplement is probably not a bad idea, especially given that many people are deficient due to spending most of their time indoors.
- Recommends getting enough vitamin D for blood pressure management.
- Recommends optimizing vitamin D levels to a serum score of around 50 to 80 nanograms per milliliter, as deficiency is linked to tinnitus volume and can assist with it.
- Recommends using hormone building blocks like vitamin D for hormone optimization.
- Notes that vitamin D deficiency is the most common deficiency.
Dr. Mark Hyman · Vitamin D · recommends
- Recommends Vitamin D for health, stating that amazing things happen when patients' vitamin D statuses reach optimal levels.
- Mentions vitamin D as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
- Notes that vitamin D plays a role in immune function.
- Recommends checking vitamin D levels and states that if they had to pick one single intervention for immune health, vitamin D would be it.
- Dr. Hyman discusses vitamin D in relation to sun exposure patterns.
- States that vitamin D supplementation can help with oxidative stress.
- Mentions vitamin D as a key nutrient for supporting immune function.
- States that vitamin D is probably the single most important intervention for immune health, recommending levels of 45 to 70 and emphasizing testing to determine the right dose.
- Notes that rickets, which causes terrible bone deformities, is caused by vitamin D deficiency.
- Notes that vitamin D is an important nutrient for brain performance and aging, and that many people have gaps in these nutrients.
Thomas DeLauer · Vitamin D · uses
- Uses vitamin D3 in the fall and winter months when getting less sun, as it's important to supplement it then.
- Recommends taking a massive amount of vitamin D simultaneously with an early morning massive breakfast to help reset circadian rhythms and address hyperphagia.
- Recommends Vitamin D, stating that it has receptors throughout the brain and deficiency can quickly impact brain and mood.
- Takes supplemental vitamin D because he is skin sensitive and from northern latitudes, limiting his UV exposure.
- Recommends taking vitamin D on non-liver days to ensure both nutrients get proper receptor access.
- Takes Purity's liquid vitamin D3 with K2 because she is constantly inside during the day; D3 is for overall wellness and K2 helps the body absorb calcium properly.
- Recommends getting vitamin D, suggesting it can be obtained while walking.
- States that vitamin D is best obtained from the sun, but getting it from food definitely helps, and notes its role as a hormone influencing many cells.
- Recommends D3, suggesting a dose of 2000-4000 IU, and notes that MK-7 slowed bone loss over three years.
- Recommends vitamin D, especially for Hashimoto's, explaining that it drives T reg expansion to suppress autoimmune responses that attack the thyroid, and notes that vitamin D and selenium deficiencies often co-occur.
Bryan Johnson · Vitamin D · uses
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Mentions that the sunlight assessment claims low vitamin D levels cause the immune system to misfire, and notes that their vitamin D has been measured.
- Takes 5000 IU of Vitamin D3 in the morning for longevity.
- He takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 5,000 IU of Vitamin D3 in the morning for longevity.
- Takes 5,000 IU of Vitamin D3 in the morning.
- Takes 5,000 IU of Vitamin D3 in the morning.
- He takes 5000 IU of Vitamin D3 in the morning for general health.
Dr. Rhonda Patrick · Vitamin D · neutral
- Vitamin D supplementation was linked to a 40% lower risk of dementia in an observational study of more than 12,000 older adults.
- Mentions that vitamin D also plays a role in maintaining muscle mass.
- Recommends ensuring adequate vitamin D intake for men's sperm health.
- Vitamin D and strength training alone did not, but adding them strengthened the effect on one clock, with the full combination slowing that measure by ~3.8 months.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Recommends Vitamin D, noting it regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity, and correcting deficiency may slow epigenetic aging.
- Uses Vitamin D3 as an example of a supplement that an AI model could track to see its impact on other metrics like glucose levels.
- Recommends Vitamin D, explaining that it regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity.
- Combining omega-3s with vitamin D and exercise has an additive effect, translating to ~3 months of slowed biological aging.
- The effect got stronger when omega-3 was combined with vitamin D and resistance training, with the full stack delaying phenotypic aging by about 3.8 months.
Andrew Huberman · Vitamin D · neutral
- Notes that most people are probably deficient in vitamin D and benefit from supplementing, but there's no point in doing it unless you're deficient for most things.
- Takes 5,000 IU of Vitamin D3 in the morning for longevity.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- States that Vitamin D is one of the critical nutrients with the best evidence for cognitive function and reducing the risk of dementia.
- Takes 5000 IU of Vitamin D3 in the morning.
- He takes 5,000 IU of Vitamin D3 in the morning for overall health.
- Takes 5000 IU of Vitamin D3 in the morning.
- Takes 5,000 IU of Vitamin D3 in the morning for general health.
- Takes 5000 IU of Vitamin D3 every day for longevity.
- Takes 5,000 IU of Vitamin D3 in the morning.
Peter Attia · Vitamin D · uses
- Lists vitamin D as one of her staple supplements.
- Notes that several studies show patients taking vitamin D can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
- States that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin D for both sexes.
- Uses vitamin D as an example of how people might dismiss its efficacy due to failed clinical trials that didn't adjust the dose or measure levels.
- In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin D for both sexes.
- Suggests that supplementing with lots of vitamin D might help overcome the negative effects of phenytoin on bone health by improving calcium absorption, though he is unaware of studies on this.
- Recommends Vitamin D3 as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 800 to 1,000 IU, which can be obtained through sunlight or supplementation.
- Suggests that supplementing with lots of vitamin D might overcome the negative effects of phenytoin on bone health by counteracting increased catabolism of vitamin D and subsequent decreased calcium absorption.
- Recommends vitamin D for people who tend to be vitamin D deficient, such as those living in Portland, Oregon.
- Discusses evaluating vitamin D, understanding deficiency, and optimal levels.
RAL Summary
Members OnlyTier 4 for Bone Health
The ineffective grade does not fit studies that disagree, including a review where 700 to 800 units a day cut hip fractures, and one review it leans on tested vitamin D-like drugs in kidney transplant patients rather than plain vitamin D3. So it is graded Tier 4, as the studies disagree.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 3 of the 13 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Skeletal system
Combine with: For bone health, pair vitamin D3 with vitamin K2 (MK-7), which helps direct calcium into bone rather than soft tissue, and with magnesium (glycinate or citrate), which is needed to activate vitamin D. Calcium from diet or a supplement may help if intake is low, and take D3 with a fat-containing meal for better absorption. If your interest is blood sugar support, consider adding berberine, chromium picolinate, alpha-lipoic acid, or Ceylon cinnamon extract, and check your 25-OH vitamin D level and discuss glucose management with a healthcare provider, especially if you take meds.
Possible side effects: No major side effects reported. One buyer found the softgels very hard to squeeze.
Supplement Facts
Vitamin D3 25 mcg
| Vitamin D3 | 25 mcg |
Other ingredients: Cold-Pressed Olive Oil, kosher Gelatin, Glycerin, purified Water.
Directions: Directions: As a dietary supplement for adults, take one (1) softgel daily, preferably with a meal, or as directed by a physician.
Barcode (UPC) 603573153137 · Label source: NIH label database · Report a label change
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- Peter Attia's Supplement List: What He Takes and What the Trials SayArticle · Sep 20, 2026
Graded November 4, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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