IML IronMag Labs Super R Andro Rx Review
IML IronMag Labs Super R Andro Rx is sold by IML IronMag Labs as a capsule supplement. The page lists a serving size of 1 capsule with 60 servings per container. The listed active ingredients are 3alpha-Hydroxy-5alpha-androstan-17-one at 100mg, 6,7 Dihydroxybergamottin at 15mg, and Piperine at 5mg. The inactive ingredients shown are Magnesium Stearate, which works as an emulsifier and lubricant, Gelatin, which serves as capsule material and binder, Silica, which works as an anti-caking and anti-foaming agent, and Rice flour, which acts as a binder, filler and texturizer. SuppCo rates each of these inactive ingredients as safe. The page states that the product has not yet been scored with a complete TrustScore, because insufficient data is available, and that a score can be requested. It also says product-specific testing is not currently verified by SuppCo. The suggested use is to take one or two capsules twice daily with food, and not to exceed four capsules in a 24 hour period. The page advises against using the product for cycles longer than 8 weeks, recommends a 4 to 8 week break between cycles, and recommends post cycle therapy after use, with more information available on the website about prohormone cycles and PCT. The page includes a standard disclaimer that the statements have not been evaluated by the Food and Drug Administration and that the product is not intended to diagnose, treat, cure, or prevent any disease.
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Study, Trial or Testing Result Summary
Members Only8 human studies · 4 improved
The main ingredient, androsterone at 100 mg per serving, has no human studies on male hormones, and neither does 6,7-dihydroxybergamottin at 15 mg. The only ingredient with any research is piperine, a black pepper compound present at 5 mg, and it has not been tested as a supplement for male hormones in people. One German study of 773 adults measured piperine in the blood at a single point in time and linked it to male hormone byproducts, but no one took piperine, so it shows no benefit [1]. Rat studies disagree. Black pepper fruit extract for 8 days raised testosterone inside the testes and improved sperm and libido in diabetic rats [2][3], and piperine brought drug-lowered testosterone back to near normal [4]. Other rat studies found harm: daily piperine for 30 days shrank the testes, lowered sperm counts and lowered testosterone inside the testes [5], and piperine with meds reduced the genes needed to make testosterone [6]. Overall, there is no human evidence that this product improves male hormones. Animal and cell studies are never counted.
See all 8 studies →Hide the studies
- In a cross-sectional German population study of 773 adults without diabetes, piperine levels in the blood were linked to androgen-related metabolites, but the study did not test piperine as a supplement and did not show that it improves male hormone levels.Sex-specific metabolic profiles of androgens and its main binding protein SHBG in a middle aged population without diabe…
- In male rats, a 200 mg per kg dose of black pepper spice was tested alongside Yaji sauce; the abstract reports that the isolated spices changed testosterone and semen measures but does not state the direction for black pepper alone.A Comparative study on the effects of Yaji (Suya Meat sauce) and its spice constituents on the male reproductive profile…
- In mice given cyclophosphamide, which damaged the testes, piperine at 5 or 10 mg per kg reduced testicular tissue damage, oxidative stress and cell death over 8 days; the abstract does not report a testosterone change from piperine.Piperine mitigates oxidative stress, inflammation, and apoptosis in the testicular damage induced by cyclophosphamide in…
- In alloxan-diabetic male rats, black pepper fruit extract at 122.5 mg per kg for 8 days increased the number of Leydig cells, which make testosterone, and improved libido, while the higher 245 mg per kg dose improved sperm measures.Fruit Extract of Black Pepper (Piper Nigrum L.) Ameliorates Male Reproductive Dysfunction in Alloxan-Induced Diabetic Ra…
- In alloxan-diabetic male rats, black pepper fruit extract at 245 mg per kg for 8 days significantly improved intratesticular testosterone, sperm concentration and normal sperm shape, and the lower 122.5 mg per kg dose improved erection and libido measures.Effects of Black Pepper (Piper nigrum L.) Fruit Extract on Sexual Function, Hormonal Parameters, Sperm Parameters, Testi…
- In male rats, piperine at 10 mg per kg given with a med for 28 days lowered antioxidant enzymes, raised oxidative damage, and reduced genes needed for testosterone production, indicating reproductive toxicity.Read the study on PubMed (40246250) →
- In male rats given 10 mg per kg of piperine daily for 30 days, testes and accessory sex organs shrank, sperm counts fell, testicular testosterone dropped, and pituitary signaling hormones rose, although blood testosterone stayed normal.Effects of piperine on testis of albino rats.
- In rats fed a high-fat diet and given carbimazole, which lowered testosterone, piperine at 40 mg per kg for 10 weeks brought testosterone back to near normal levels along with thyroid hormones and lipids.Piperine, an active principle from Piper nigrum, modulates hormonal and apo lipoprotein profiles in hyperlipidemic rats.
Review Totals and Summary
Members OnlyWhat buyers say
Customer feedback is sparse, mixed, and mostly from eBay buyers of the Super Epi-Andro Rx. Fewer than twenty ratings were available, so the themes below are tentative. Positive reviewers say the product does what it claims. They like the price and report good results, and some say they will buy again. One user called it a good pro-DHEA type supplement. They described a calm, improved sense of well-being and "decent" workout gains. Others, in similar tones, praise the brand's whole range as reliable and fairly priced. The criticisms are more specific. A few buyers say the effects are subtle. One noted little effect on libido. Another reported feeling nothing even after taking several times the recommended dose, and said they moved on to stronger products. Side effects appear at higher doses. One reviewer got headaches when taking more than one capsule a day. They also thought they might be sensitive to DHT-type compounds, and said blood pressure rose when they took more. They advised caution with dosing. One skeptical buyer, who had bought the product several times, called the packaging "sketchy" and easy to tamper with. They worried that someone could open the capsules and remove the contents. This is a trust and authenticity concern. A few reviews were also titled with hype-related skepticism. Overall, the pattern is polarized. Some users find the product mildly effective, with a calming mood effect and value for money. Others see no benefit, or get headaches and higher blood pressure at larger doses. Many seem to see it as a mild, entry-level compound. People who want strong results report disappointment. There was little feedback from other regions, and I found no detailed lab-verification or independent professional analysis. SuppCo had not yet scored the product.
Biohacker Summary
Members Only3 of 10 recommend it
Seven of the ten panelists spoke about piperine, the main ingredient, and they are split, with the most recent positions leaning toward caution. Two of them recommend it, and a few more use it or describe it as a way to help the body absorb curcumin, usually taken as black pepper with turmeric, and one also mentions it for helping with resveratrol absorption and for autophagy, based on rodent work that has not been replicated in humans. Four of the seven warn about it, saying it can slow how the body clears meds and other compounds, which could leave more of a med in the blood for longer, and one of them says it blocks a liver detox enzyme. One panelist cautions that high doses, such as 20 or 30 milligrams, could raise gut inflammation and advises care when stacking supplements that contain it. No one gave a preferred form beyond ground black pepper, and none of them said they stopped taking it.
See all 7 biohackers →Hide the biohackers
Thomas DeLauer · Piperine · recommends
- Recommends taking piperine with curcumin to increase its bioavailability, as curcumin gets metabolized before it can do anything without it.
- Recommends a piperine supplement to improve autophagy, citing a rodent study where piperine prevented neurotoxic effects and increased autophagy by inhibiting mTor X1.
- Discusses piperine's potential to improve resveratrol absorption by slowing its metabolism, citing a rodent study that showed a significant increase in serum resveratrol, but notes that this has not been successfully replicated in humans.
- Notes that piperine is included in a supplement to help with absorption.
Siim Land · Piperine · warns
- Warns that piperine affects the metabolism of many drugs, and taking it shortly before certain medications could lead to a much higher concentration of the medication in the blood.
Dave Asprey · Piperine · warns
- Warns that high doses of piperine, such as 20 or 30 milligrams, could raise inflammation in the gut and advises caution when combining supplements containing it.
- Explains that piperine, from black pepper, is included in the formulation to increase the absorption of multiple active ingredients in the gut.
Dr. Eric Berg · Piperine · neutral
- States that adding piperine, a phytonutrient from black pepper, at the same time as curcumin can increase curcumin absorption by 2000%.
- Identifies piperine as the main phytonutrient in black pepper that benefits health, but also notes that it can increase the bioavailability of toxic substances and prevent the liver from getting rid of toxins.
Ben Greenfield · Piperine · warns
- Warns that piperine in pepper inhibits UDP-glucuronosyltransferase, a phase 2 detoxification enzyme.
- Warns against supplementing curcumin with piperine, stating that it dangerously increases absorption by inhibiting UDP glucuronosyltransferase, leading to increased side effects.
- States that piperine inhibits the body's natural detoxification process by inhibiting UDP glucuronosyltransferase and is added to curcumin supplements to increase curcumin absorption, but these molecules are not used in human biochemistry.
- Ben Greenfield's guest explains that piperine, found in black pepper, inhibits the UDP-glucuronosyltransferase enzyme in the liver, which is crucial for detoxifying compounds by making them water-soluble for excretion.
- Ben notes that piperine from black pepper is used as a smoking cessation treatment, often by whiffing black pepper essential oil.
Dr. Rhonda Patrick · Piperine · warns
- Warns that piperine should be avoided by people taking meds because it can extend the half-life of the drug, which could have unknown effects.
- Consumes turmeric with ground pepper (piperine) to increase its bioavailability and absorption.
- Piperine from black pepper increases the bioavailability of curcumin.
- Tim Ferriss consumes piperine (ground pepper) with turmeric to increase its bioavailability and absorption.
Dr. Mark Hyman · Piperine · recommends
- Recommends consuming piperine, found in black pepper, with curcumin to make it easier for the body to absorb, enhancing its anti-inflammatory benefits.
RAL Summary
Members OnlyTier 4 for Hormone Balance for Men
The review summary describes buyers of IronMag Labs Super Epi-Andro Rx, a different product with a different main ingredient, so it is set aside for this androsterone product. Its reviews are set aside, so it is graded on its studies alone. Animal studies support Piperine, but there are not yet enough reviews to confirm it (0).
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 2 of the 8 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Endocrine system, Reproductive system
Combine with: For male hormone support, this product is commonly stacked with zinc, magnesium, vitamin D3, and boron, which support normal testosterone production, plus ashwagandha to lower cortisol and fenugreek or Tongkat Ali for androgen and libido support. If the user truly wants cellular and DNA repair, they should use different products such as NMN or nicotinamide riboside with TMG, resveratrol or pterostilbene, CoQ10 or PQQ for mitochondrial function, alpha-lipoic acid, and omega-3s. Spermidine, quercetin with fisetin, and vitamin D3 with K2 also have more relevant anti-aging rationale. Anyone with hormone-sensitive conditions or on medication should consult a healthcare provider before using testosterone-targeting supplements.
Possible side effects: No human side effects reported in the studies; in rats, piperine at high doses shrank the testes and lowered sperm counts.
Supplement Facts
3alpha-Hydroxy-5alpha-androstan-17-one 100 mg · 6,7 Dihydroxybergamottin 15 mg · Piperine 5 mg
| 3alpha-Hydroxy-5alpha-androstan-17-one | 100 mg | † |
| 6,7 Dihydroxybergamottin | 15 mg | † |
| Piperine | 5 mg | † |
Other ingredients: Rice Flour, Gelatin, Magnesium Stearate, Silica.
Directions: Suggested Use: As a dietary supplement, take one (1) or two (2) capsules twice daily with food. Do not exceed four (4) capsules in a 24 hour period. Do not use this product for cycles lasting longer than 8 weeks, A 4-8 week break is recommended between cycles. Post cycle therapy is also recommended after use of this product; see our website for more information on Prohormone cycles and PCT.
Barcode (UPC) 685987323856 · Label source: NIH label database · Report a label change
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Graded November 4, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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