INNOSUPPS Inno Shred Focus Review
This eBay listing offers Innosupps Inno Shred Focus 60 Capsules, sold as a new item by the seller smartmart101, which is located in Naperville, Illinois, United States. The listing title reads Innosupps Inno Shred Focus 60 Capsules, and the item is shown with a Buy It Now option priced at US $39.00, or Best Offer. The price can also be paid in four interest-free payments of $9.75 through Klarna, with the first payment due at checkout. The page states the condition as New. Shipping is listed at US $6.76 via USPS Ground Advantage, and the estimated delivery window is Friday, November 6 to Tuesday, November 10 for the destination ZIP 96001. Returns are accepted within 30 days, and the seller pays for return shipping. The listing also states that the item is covered by the eBay Money Back Guarantee, which promises the item ordered or a refund. Accepted payment methods shown are Diners Club and Klarna. The gallery includes three product photographs. The first shows a white and red container for Inno Shred Focus 60 capsules with a lightning bolt design and an accompanying white box. The second shows the white container with red and black text, with the supplement facts and ingredients list displayed on the label. The third is a close view of a white plastic capsule bottle with gold text showing a lot code and expiration date, along with a red Innosupps logo on the bottom. The listing describes the product as a 60 capsule count. The page does not print a full ingredient list, a serving count, or a barcode in its text, so those details are only visible in the label images and are not reproduced here. The seller smartmart101 is shown with 7783 feedback ratings and a 99.7 percent positive seller rating. That figure reflects seller feedback rather than ratings of this particular product. The page also notes that seven people have added the item to their watchlist. A volume discount banner from the seller offers 10 percent off two items, 15 percent off three items, and 20 percent off four or more items, with a link to view eligible items and terms. The item can be added to a cart, purchased as a guest, or purchased after signing in, and a Make offer option is available. The page displays a notice that the site had trouble connecting to its server and invites the visitor to refresh the browser window. Several related listings for other supplements from the same category appear further down the page, including other InnoSupps products, but those are separate items and are not part of this listing.
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Study, Trial or Testing Result Summary
Members Only35 human studies · 8 improved
The main ingredients of this product are hidden in three proprietary blends, a thermogenic complex, a focus matrix and an appetite and carb blocking matrix. No human studies were found for these blends, so there is no direct evidence for or against them. The rest of the label is small amounts of vitamins, all below the doses that were studied. For vitamin B12, a large two-year trial in older adults using a much higher dose found no change in body mass index, fat mass or lean mass compared with placebo [1]. Studies linking low vitamin B12 to higher weight show only an association [2][3]. For vitamin B6, one old study found greater weight loss when it was added to a reduced diet, but the dose was not reported [4]. A trial using a far higher dose in people with a nerve disease found more weight loss, which was not the aim there [5]. For choline, people whose diet choline rose lost more weight, but this shows a link, not cause [6]. Eating eggs lowered weight in one small trial [7], while a choline-containing krill oil did not add to weight loss [8]. Overall the evidence is thin. Animal and cell studies are never counted.
See all 35 studies →Hide the studies
- In 2,919 adults aged 65 and older with high homocysteine, two years of daily vitamin B12 (500 mcg) plus folic acid did not change body mass index, fat mass or lean mass compared with placebo.B-vitamins and body composition: integrating observational and experimental evidence from the B-PROOF study.
- In 506 gastric bypass patients, a longer bypass limb gave no extra weight loss, but those patients needed more vitamin B12 supplementation; this trial did not test B12 as a weight treatment.Impact of Biliopancreatic Limb Length (70 cm vs 120 cm), with Constant 150 cm Alimentary Limb, on Long-Term Weight Loss,…
- In 110 adults with obesity on a weight loss diet, three months of synbiotic tablets gave similar weight loss to diet alone; vitamin B12 blood levels rose in the synbiotic group, but B12 itself was not given.The Effect of Prebiotics and Probiotics (Synbiotics) on Weight Loss and Biochemical Parameters in Obese Individuals.
- In 95 people with amyotrophic lateral sclerosis, 160 mg a day of pyridoxal phosphate given with L-threonine for six months was linked to more weight loss (3.2 kg) than placebo (1.1 kg), so it did not help keep weight on.A controlled trial of amino acid therapy in amyotrophic lateral sclerosis: I. Clinical, functional, and maximum isometri…
- In 70 people with heart risk factors, an 8-week plant-based diet lowered body weight but did not supply enough vitamin B12; B12 was not given as a supplement.Does a Plant-Based Diet Stand Out for Its Favorable Composition for Heart Health? Dietary Intake Data from a Randomized …
- In 53 healthy adults, 4 weeks of an unsupplemented vegan diet lowered vitamin B12 status markers compared with a meat-rich diet, and body weight stayed stable in both groups.Vitamin B12 Status Upon Short-Term Intervention with a Vegan Diet-A Randomized Controlled Trial in Healthy Participants.
- In 41 adults with overweight or obesity (16 men, 25 women) doing alternate-day fasting for 8 weeks, krill oil containing choline (about 312 mg choline per day) did not change weight loss compared with placebo (about 4.6 kg vs 4.5 kg), though it reduced loss of fat-free mass and grip strength.Benefits of Krill Oil Supplementation During Alternate-Day Fasting in Adults With Overweight and Obesity: A Randomized T…
- In 24 adults with metabolic syndrome (13 women, 11 men) on a plant-based diet, eating two eggs daily for 4 weeks led to lower body weight and higher blood choline than an egg substitute breakfast, in a crossover trial; results were not reported separately for men.Eggs Improve Plasma Biomarkers in Patients with Metabolic Syndrome Following a Plant-Based Diet-A Randomized Crossover S…
- In a 1975 study of people with diet-related obesity who were on a reduced diet, adding pyridoxine (vitamin B6) led to greater drops in body weight and blood fats than diet alone, with a stronger effect in people with high blood lipids.[Effect of pyridoxine on patterns of lipid metabolism in patients with alimentary obesity].
- In over 5,600 adults with metabolic syndrome and overweight, the largest one-year increase in dietary choline or betaine was linked with a 2.9 kg greater reduction in body weight and a 3.4 cm smaller waist over one year.One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in …
- In 2797 pregnant women, a higher pre-pregnancy body weight was linked to lower vitamin B12 levels and more inflammation; no supplement was tested.Impact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Study.
- In a study of 1945 Colombian children aged 5 to 12, boys with marginal or low vitamin B12 had lower standing long jump scores, and children who were overweight or obese ran slower than normal-weight children; this was not a supplement trial.Micronutrient and anthropometric status indicators are associated with physical fitness in Colombian schoolchildren.
- In a 2010 survey of 1530 women of reproductive age in Vietnam, body weight category was not linked to vitamin B12 deficiency, which was found in 15% of overweight or obese women; this study covered women only, not men.Intra-individual double burden of overweight and micronutrient deficiencies among Vietnamese women.
- In 237 children and 524 parents from Central America and Mexico, higher vitamin B12 was linked to a lower metabolic risk score in children but to more metabolic syndrome in adults; no supplement was given.B-vitamins and metabolic syndrome in Mesoamerican children and their adult parents.
- In 537 patients after sleeve gastrectomy, low blood vitamin B12 fell from 30.3 percent before surgery to 16.4 percent at 5 years, while patients were given multivitamins and weight loss was not tied to vitamin B12.Long-term nutritional impact of sleeve gastrectomy.
- Among 477 male bus drivers and field officers with COVID-19 in Istanbul, body mass index and vitamin B12 values differed between those who recovered at home and those treated in hospital, but the abstract does not give the direction of the vitamin B12 difference and this was not a weight management study.Clinical characteristics of bus drivers and field officers infected with COVID-19: A cross-sectional study from Istanbul…
- A survey of 334 Mongolian adults found that vitamin B12 intake from food was rarely inadequate, and overweight was common, but the study did not test vitamin B12 for weight management.Diet and Nutrition Status of Mongolian Adults.
- Among hypertensive adults, those who were overweight or obese had lower vitamin B12 and folic acid levels and higher homocysteine than those of normal weight; this was a cross-sectional comparison and did not test supplements.Plasma homocysteine in obese, overweight and normal weight hypertensives and normotensives.
- In 100 elderly residents of private care homes in Tehran (37 men and 63 women), vitamin B12 intake was low, and almost half were underweight for their age and sex; no supplement was tested.Food intake and Body Mass Index in the privately institutionalized elderly in Tehran.
- In 92 young Saudi women, vitamin B12 status was linked to gut bacteria patterns, which differed between those with obesity and those of normal weight; no supplement was given and the study did not include men.Vitamin B12 Status and Gut Microbiota among Saudi Females with Obesity.
- In 86 centenarians, higher blood vitamin B12 was linked to higher electrocardiogram voltage, but vitamin B12 was not given and body weight was not a study outcome.ECG low QRS voltage and wide QRS complex predictive of centenarian 360-day mortality.
- In a retrospective review of 84 children and teenagers with phenylketonuria, vitamin B12 was often elevated, and it was not clearly tied to overweight; no vitamin B12 supplement was given.Nutritional and metabolic parameters of children and adolescents with phenylketonuria.
- In a cross-sectional study of 80 children and teenagers with phenylketonuria, high blood levels of vitamin B12 were found in some patients, and weight was not linked to vitamin B12 levels; no vitamin B12 supplement was given.Growth and Nutritional Status of Phenylketonuric Children and Adolescents.
- In 79 pregnant women, blood vitamin B12 did not differ between those with and without gestational diabetes, though lower vitamin B12 went with higher fasting glucose and worse fats in the blood.Serum homocysteine and vitamin B12 levels in women with gestational diabetes mellitus.
- In 70 patients after weight-loss surgery, vitamin B12 levels fell in those who lost at least half of their excess weight, and the authors suggest nutritional supplements may be needed; no supplement was tested.Skin manifestations after bariatric surgery.
- In 59 adults, those with depression had lower blood vitamin B12 and higher waist measurements than controls, but no vitamin B12 supplement was tested.Evaluation of Nutritional Status of Patients with Depression.
- In a cross-sectional study of obese women, lower vitamin B12 levels were linked to higher BMI, and obese women were more likely to be B12 deficient (37.6% versus 24.7% in non-obese women); this shows an association, not a supplement effect.Evaluation of serum Vitamin B12 level and related nutritional status among apparently healthy obese female individuals.
- In a retrospective real-world study of 94 people, mostly women, weekly compounded a med with cyanocobalamin (vitamin B12) produced an average weight loss of 4.11 kg (4.57%) over 3 months, with fat mass falling and lean mass rising as a share of total weight; the study had no control group and did not test vitamin B12 on its own.Read the study on PubMed (39776038) →
- In 41 patients after gastric bypass for obesity, most achieved adequate weight loss, but many developed vitamin B12 deficiency; those with milder deficiency responded to 50 micrograms of oral vitamin B12, while severely deficient patients did not.Late effects of gastric bypass for obesity.
- In a retrospective series of 30 mostly female patients after single anastomosis sleeve ileal bypass surgery, mean body mass index fell from 45.6 to 25.8 over 12 months, but 6.6% had vitamin B12 deficiency and malnutrition was common.The Alarming Rate of Malnutrition after Single Anastomosis Sleeve Ileal Bypass. A single Centre Experience.
- In obese mice, vitamin B6 lowered the expression of an inflammation-linked gene in fat tissue, but the abstract does not report any effect on body weight; this was a mouse and cell study, not a human trial.IκB kinase epsilon expression in adipocytes is upregulated by interaction with macrophages.
- In a 28-day study in young male rats, adding wheat bran or cellulose fiber to the diet did not reduce vitamin B6 absorption or status, and vitamin B6 intake affected growth; this was an animal study and did not measure weight management.Bioavailability of vitamin B-6 from rat diets containing wheat bran or cellulose.
- In a rat model of chronic stress, vitamin B6 supplementation during stress reduced weight loss, abnormal behavior, and peripheral and brain inflammation; this was an animal study, not a human trial.Gut dysbiosis-induced vitamin B6 metabolic disorder contributes to chronic stress-related abnormal behaviors in a cortis…
- In a mouse study, mothers given choline during a high-fat diet had male offspring with better blood sugar control after six weeks of high-fat feeding, while female offspring showed minimal effects; this was not a human study and weight was not reported as improved.Prenatal Choline Supplementation during High-Fat Feeding Improves Long-Term Blood Glucose Control in Male Mouse Offsprin…
- In a mouse study, sea cucumber ether-phospholipids given at 150 mg per kg of body weight for eight weeks reduced liver fat buildup and boosted autophagy in the brain's hypothalamus in mice fed a high-fat diet; this was not a human study.Sea cucumber ether-phospholipids improve hepatic steatosis and enhance hypothalamic autophagy in high-fat diet-fed mice.
Review Totals and Summary
Members Only28,000 reviews · 95% positive
Overall, buyers are very positive. They describe weight loss and a better quality of life, usually when the product is paired with exercise and healthier eating. The reviews are brand-wide and mostly general, so they say little about the capsules in particular. **What buyers say it did for them:** Most reviewers report losing weight, some of them a lot. One wrote, "I lost 70lbs in 5 months," and another said, "I'm steadily losing three pounds a week." One person went from 265 to 200 pounds and from 40% to 20% body fat in a year, though that came from "going to the gym and using Inno Supps every day." Others mention feeling better overall. One said, "I sleep well. I'm eating healthy food." Another felt the supplements "boost my metabolism, improve my digestion" and enhance weight loss. **What they complain about:** The reviews contain no complaints. One reviewer admitted the process "was still a challenge," but they presented that as the nature of weight loss rather than a fault of the product. Nobody reports side effects, disappointment or lack of results. Nobody mentions a problem with shipping, either. Still, a set of reviews this uniformly glowing gives you little information about downsides. **Taste, smell, pill size or form:** The reviews say nothing about these. Nobody mentions how big the capsules are, how they smell or how easy they are to swallow. Some reviews on the store page may cover other forms of the product, such as gummies or powder. I left those out and wrote only about the capsules, though these particular reviews rarely say which form was used. **Value for money:** Nobody comments on price or cost. One reviewer said the product "has by far exceeded my expectations," but that is about results, not price. There is nothing here to judge whether it is good value. **Who it seems to suit and who it did not:** The reviews point to people who want to lose weight and are willing to change how they eat and exercise. One reviewer recommends it to anyone "struggling and in a rut," and another says they "would not be where I am" without it, though they also credit healthy eating and exercise. Several mention taking it every day, so it seems to suit people who will stay consistent. One reviewer was won over after being unsure about social media ads. No reviews describe anyone it did not work for, so I can't say who should avoid it. **Bottom line:** The feedback is enthusiastic and centers on weight loss alongside diet and gym habits. It says almost nothing about the capsules' form, taste, cost or drawbacks. The results people describe came with lifestyle changes, so don't expect the capsules alone to produce them.
Biohacker Summary
Members Only8 of 10 recommend it
This product has no main ingredient listed here, only three smaller ingredients, and the panel spoke about all of them. Choline drew the most attention: most of the panel recommend or use it for focus, memory, cell membranes and liver function, often from eggs, organ meats or other foods, and one prefers a plant-based form and pairs it with racetams, while another prefers food over supplements. Cautions on choline include one panelist who warns against supplementing it directly and three who raise concern about a byproduct called TMAO and suggest checking levels. Vitamin B12 is a smaller ingredient in this product, and most of the panel recommend keeping levels healthy for brain function and mood, with one preferring methylcobalamin in liposomal form and another warning against taking it close to bedtime. Vitamin B6 is also a smaller ingredient in this product, with panelists favoring the active P5P form over pyridoxine hydrochloride and pairing it with magnesium or with folate and B12.
See all 10 biohackers →Hide the biohackers
Thomas DeLauer · Vitamin B12 · recommends
- Recommends Vitamin B12 for mental health and mood, explaining its role in myelination and neurotransmitter production. They specifically recommend a liposomal and micellar form of methylcobalamin B12 for better absorption and to avoid toxicity.
- Mentions that choline from avocado (and eggs) contributes to the liver's ability to tag and process toxins, focusing on phase II detox.
- Mentions that a single serving of sardines provides vitamin B12 at something like three to four times the daily needs.
- Recommends taking methylcobalamin as a methylated form of B vitamin for mitochondrial function.
- Recommends ensuring adequate vitamin B6 intake, as it is a required cofactor for cells to use absorbed magnesium and improves central nervous system relaxation when combined with magnesium.
- Explains that choline is the direct precursor to acetylcholine, a neurotransmitter tied to memory, attention, and learning speed, and that most adults don't get enough of it.
- Recommends vitamin B6 to support GABA production and find balance for mental clarity.
- Recommends eating eggs in the morning to get choline, which aids the liver's ability to clear excess cortisol.
- Highlights choline, found in liver and eggs, as a crucial nutrient for cardiovascular health, reducing inflammation, protecting the brain, and supporting cognitive functions like focus and memory.
- States that choline is important for reducing homocysteine.
- Mentions B12 as a critical B vitamin for reducing homocysteine.
- Advises against taking vitamin B12 if one's diet already provides enough, suggesting a B complex or liver capsule instead for B vitamins.
- Notes that eggs contain choline, which is a precursor to acetylcholine, a neurotransmitter essential for brain energy.
- Was taking Vitamin B12 with fat burner injections, which he later stopped cold turkey, leading to a period of intense emotional and hormonal imbalance.
Dr. Eric Berg · Choline · neutral
- Mentions that egg yolks contain choline, which helps the brain and prevents a fatty liver.
- Notes that choline is a key nutrient many people are deficient in, helping repair membranes, reduce breakouts, improve skin texture, and lift brain fog by being a building block for acetylcholine, which aids memory, focus, and concentration.
- Dr. Berg lists pyridoxine hydrochloride as a synthetic vitamin to avoid.
- Recommends taking the active form of vitamin B6, pyridoxal-5-phosphate (P5P), for its benefits to the nervous system, including building the myelin sheath and protecting sensory nerve integrity.
- Notes that Vitamin B6 is intimately involved in the nervous system and may be behind sciatica and carpal tunnel syndrome.
- Recommends taking the natural form of vitamin B12, methylcobalamin, to support nerve regeneration, myelin production, and nerve growth factors.
- Notes that Vitamin B12 is intimately involved in the nervous system and may be behind sciatica and carpal tunnel syndrome.
- Recommends increasing choline in the diet for better sleep, found in egg yolks, liver, grass-fed meat, salmon, and cruciferous vegetables.
- Recommends focusing on choline-rich foods to support liver health and help fuel the brain throughout the night.
- Recommends taking vitamin B12 if on a med.
- States that high vitamin B6 levels can be linked to peripheral neuropathy.
- Briefly mentions Vitamin B12 in relation to neuropathy.
- States that eggs are a rich source of choline, a nutrient the body uses to make acetylcholine, which plays an important role in memory and other brain functions.
- States that vertical ridges on nails could mean a vitamin B12 deficiency, and slightly brown or grey nails, especially for vegans, could indicate low B12. Completely white nails with a pink strip across the top could also be low B12.
Dave Asprey · Choline · recommends
- Recommends increasing choline intake, noting that it is missing in most people's diets and is important for cell membranes and liver function. He switched to a new American-made, plant-based choline called Vitacoline, which has prenatal clinical studies.
- Dave Asprey recommends eating eggs or taking a supplement that raises acetylcholine when taking racetams, as racetams can burn through choline, which the brain needs for focus.
- Dave explains how to stack racetams with choline for smarter cognitive enhancement.
- Recommends taking choline donors, especially if over 35, to prevent headaches and muscle tension that can occur when taking racetams due to increased demand on the acetylcholine system.
- States that Vitamin B12 is extremely important for every kind of brain function and recommends ensuring B12 levels are optimal, around 500, not just barely above normal.
- Mentions Vitamin B6 as playing a role in methylation pathways.
- Recommends taking vitamin B12 if one has a deficiency.
- Egg yolks, particularly raw egg yolks, fatty cuts of meat, choline sources like that, making sure there's enough iron and a lot of the micro minerals, trace minerals, things like that. Those would be really important for bone marrow because mineral deficiencies are going to block that at the start.
- States that the liver needs choline to package hormones for removal, and the detox process doesn't work without it.
- Notes that a gene related to choline transport can increase the risk of cognitive decline by about 60%.
- Warns that the synthetic form of vitamin B6 found in almost all multivitamins and energy drinks binds to B6 receptors for a thousand days, making them unavailable for the beneficial form.
- Dave Asprey discusses choline in relation to fatty liver.
- Warns that choline by itself isn't great to take because it doesn't absorb well and can ferment in the gut to produce TMAO, which is undesirable.
- Dave recommends taking a choline donor when taking Piracetam because Piracetam depletes acetylcholine.
Dr. Mark Hyman · Vitamin B6 · uses
- Optimized a child's nutrient status with vitamin B6, as the child had low B6 levels.
- States that vitamin B12 is a nutritional deficiency that impacts mental health.
- Recommends vitamin B6 with folate and B12 as supplements with strong evidence for PMS.
- Recommends vitamin B12 with vitamin B6 and folate as supplements with strong evidence for PMS.
- Believes that if functional testing is done to replete deficiencies like vitamin D and B12 before someone stops their medication, withdrawal symptoms can be completely eliminated.
- Mentions that repletion of vitamin B12 can help safely withdraw someone from meds and that simple vitamin B12 deficiencies are important to address in a depression workup.
- Lists Vitamin B12 as important for nerve health and energy.
- Recommends that pregnant women consume enough choline, ideally from four eggs a day, to support their baby's brain development and prevent irreparable brain damage, as 90% of pregnant mothers are below the minimum recommended amount.
- Dr. Hyman discusses choline as one of the nutrients that matter most during pregnancy.
- Mentions vitamin B12 as a core nutrient required for methylation, noting that deficiencies can lead to various health issues.
- Recommends supplementing with Vitamin B12 for hair follicle health and growth, especially for vegans, as many people are deficient.
- Recommends checking vitamin B12 levels as a first step before taking any supplements.
- Warns that meds (meds) block the absorption of vitamin B12, which requires stomach acid to be absorbed. Long-term B12 deficiency can lead to depression, neurological problems, and dementia.
- States that Vitamin B6, at 50 to 100, is important for estrogen metabolism.
Ben Greenfield · Choline · uses
- Addresses her MTHFR gene by taking choline rather than high doses of methylolate.
- Recommends getting vitamin B12 tested and supplementing if deficient, as B12 deficiency can cause damage to the myelin coating around nerves, including cochlear nerves, and improve tinnitus severity scores.
- Recommends consuming choline from natural sources like runny egg yolks, organ meats, soy, and walnuts to support vagus nerve function.
- Mentions high doses of choline as something used in 'old school biohacking days' for focus.
- Discusses whether TMAO from eating carnitine and choline, which have benefits, is the same as TMAO from gut dysbiosis and kidney failure, questioning the reason for elevation.
- Recommends Vitamin B6 for the conversion of tryptophan to serotonin and then melatonin in the pineal gland.
- He recommends Vitamin B12, especially for kids on a vegan or vegetarian diet, as it is essential for nervous system development.
- Mentions that blood testing for an energy crisis would include nutritional things like a vitamin B12 level.
- Ben Greenfield consumes vitamin B12 as part of the Update Energy Drink.
- Julie focuses on taking a lot of choline to address her MTHFR gene, as high doses of methylfolate cause her anxiety.
- Ben recommends choline, a good source of alpha GPC, as 'brain fuel' to help with exhaustion experienced after micro-dosing.
- Suggests using choline to replete the brain's fuel when using substances like psilocybin or LSD, and recommends it as a brain-refueling compound.
- Ben discusses the importance of choline for creating molecular compounds in the brain that become depleted after traumatic brain injury, concussion, or in early onset dementia or Alzheimer's.
- Mentions Morley Robbins's argument that synthetic vitamin C lacks choline, but Chris Masterjohn points out that the best sources of choline are seeds and nuts, which have the least vitamin C.
Andrew Huberman · Choline · recommends
- Recommends choline-rich foods to enhance focus and acetylcholine.
- Mentions choline as a structural lipid component, obtainable from nuts, seeds, or eggs, that seems related to cognitive function, though with slightly less evidence for brain changes over time and dementia risk.
- Notes that choline can be converted into TMAO, similar to L-carnitine, and suggests measuring TMAO levels if supplementing with it.
- States that a deficiency in vitamin B12 can be terrible and lead to chronic fatigue-like syndromes, as many parts of mitochondria require B vitamins.
- He highlights specific nutrients, including choline, and discusses their recommended doses and dietary sources for focus.
- Recommends Alpha GPC, also known as alpha glyceryl phospho-choline, for enhancing power output and potentially improving cognitive function, especially in older populations. He notes that dosages of 300 to 600 mg taken before training have been shown to increase power output by about 14%.
- Recommends taking methyl B12 as part of methylated B vitamins to lower homocysteine levels and reduce cardiovascular risk.
- Has been taking AG1 for over 10 years, once and often twice every day, to ensure he gets all necessary vitamins, minerals, probiotics, and adaptogens, considering it a nutritional insurance policy.
- Does not supplement B6 due to evidence that overs-supplementing vitamin B, especially B6, is problematic because of peripheral nerve damage.
- Has been taking AG1 since 2012 to ensure he gets enough vitamins, minerals, Prebiotic fiber, and other nutrients typically found in fruits and vegetables, providing nutritional insurance.
- Mentions supplementation with choline donors as a way to increase acetylcholine and dopamine to offset age-related cognitive decline.
- Mentions that Alpha GPC, typically taken at 300 to 600 milligrams, is often combined with L-Tyrosine to enhance dopamine and acetylcholine and promote neuroplasticity, though its efficacy for neuroplasticity is not as well-studied as meds.
- Andrew Huberman started drinking AG1 in 2012 and still drinks it once or twice a day because it provides all his foundational nutritional needs, ensuring proper amounts of vitamins, minerals, probiotics, and fiber for optimal mental health, physical health, and performance.
- Notes that some people are exploring the use of P5P, a metabolite of vitamin B6 known to suppress prolactin, as a way to buffer the post-MDMA crash, though there are no human data yet.
Dr. Rhonda Patrick · Choline · neutral
- States that choline helps make acetylcholine for cognition and phosphatidylcholine for cell membranes, and can be converted into betaine to help clear homocysteine.
- Choline plays a critical role in fetal brain development, and the form and dose matter. Pregnant women who supplemented with twice the RDA for choline (900 mg/day) had children with higher intelligence scores than women taking 450 mg/day.
- Recommends that pregnant women supplement with choline, specifically phosphatidylcholine, to potentially have smarter babies, citing a randomized controlled trial where mothers who nearly doubled their choline intake had children who scored higher on IQ and cognitive tests.
- Warns that Vitamin B12 enhances light's melatonin-suppressing effects and should be avoided too close to bedtime.
- Discusses which choline supplement won't raise TMAO.
- Choline is vital for brain function and development, and even slight deficiencies can elevate homocysteine levels, which is linked to cardiovascular disease and cognitive decline.
- Recommends that pregnant women consume 900 mg of choline per day for greater outcomes in a child’s cognitive, attention, and possibly social development.
- Discusses how choline during pregnancy could make a child more intelligent.
- Notes that a med can cause vitamin B12 deficiency, especially as absorption decreases with age, and suggests a sublingual form or B12 injections for older individuals.
- Discusses the origin of Vitamin B12, suggesting it's a microorganism that propagates in the soil and that animals get it from eating dirt, which is why it's less available in modern, sanitized plant foods.
- Dr. Patrick states that choline, abundant in egg yolk, is a precursor for acetylcholine, important for learning and memory, a source of methyl groups for epigenetics, and a precursor for phosphotidylcholine, essential for cell membranes and preventing fatty liver.
- Dr. Patrick states that people with a specific gene polymorphism in the NPF3 gene, which affects vitamin B6 levels, may need to increase their dietary intake of B6 and/or supplement with vitamin B6.
- Vitamin B6 can suppress the production of Advanced Glycation End products.
- Describes a study where female mice fed a diet high in B vitamins, folic acid, and vitamin B12 three weeks before pregnancy had offspring that no longer had yellow fur and were not predisposed to obesity and cancer.
Siim Land · Vitamin B12 · uses
- Created Microvitamin, a supplement that bundled all the supplements he was taking, to help fund his a med trial.
- States that vitamin B12 deficiency is the most common reason for premature graying of hair and recommends fixing B12 status if it is deficient, as it gives a greater likelihood of reversing gray hair.
- Is a big fan of consuming lots of choline through eggs, eating two to four eggs a day minimum, and also supplements with nootropics that contain choline.
- Warns against supplementing choline directly due to potential downsides related to TMAO function, preferring to get it from dietary sources like egg yolks or liver.
- Mentions that insufficient vitamin B6 can raise prolactin levels.
- Recommends B12 for vegans, noting it is a standard vitamin found in animal products.
- Ensures he gets enough dietary choline regularly, primarily from eggs, which he believes covers his requirements, especially since he eats less fat overall.
- Questions the redundancy of stacking multiple choline supplements like phosophocholine and CDP choline, noting that choline is also obtained from food and it's unclear which ones are necessary or effective.
- Recommends supplementing with choline to help optimize methylation.
- Is experimenting with serine plus vitamin B6 to impact homocysteine levels, a mechanistic hypothesis he is testing.
- Choline is a methyl donor that can be exclusively obtained from animal products and is important for DNA methylation.
- Recommends choline as an essential nutrient for preserving cognitive function and safeguarding against neurodegeneration, playing a pivotal role in regulating memory, muscle function, and various vital processes in the brain and nervous system.
- Recommends getting choline from dietary sources like egg yolks and liver, as it supports methylation and is important for preventing Alzheimer's and neurodegeneration, as well as maintaining good liver health.
- Takes 1 gram of Vitamin B12 from DoNotAge in the morning for longevity.
Bryan Johnson · Vitamin B12 · uses
- States that Blueprint essential capsules and soft gels are packed with key vitamins and minerals needed for strong bone health.
Peter Attia · Vitamin B12 · neutral
- Notes that deficiencies in certain vitamins and minerals, such as B12, can be a cause of hair loss in women.
- States that for choline deficiencies, which are sometimes measurable and seen in people post-bariatric surgery, they are not terribly aware of any downsides to taking choline supplements, but cautions about quantifying what's in supplements.
- Peter Atia asks Chris Masterjohn about the required choline dose for a patient with non-alcoholic fatty liver disease, and Chris guesses around 1200 milligrams, which would be difficult to achieve through food alone.
- Explains that when a person is not responding to traditional B vitamins, they will step it up and give them methylcobalamin B12.
- Notes that Ryan Lochte was suspended for a doping rule violation after a social media post showed him taking vitamin B12 in an illegal way, by IV infusion.
RAL Summary
Members OnlyTier 4 for Weight and Metabolism for Men
The ineffective grade rests on vitamin B12, a trace vitamin at a low dose, while the main ingredients sit in proprietary blends with no human studies, so the evidence is thin rather than showing the product does not work. So it is graded Tier 4, as the studies disagree.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 24 of the 35 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Metabolic system, Nervous system, Digestive system
Combine with: For the product's intended purpose (energy, focus, and weight management support), it pairs well with green tea extract (EGCG), which complements caffeine for thermogenesis, plus choline or alpha-GPC for cognitive support, and electrolytes with adequate hydration to offset caffeine's mild a med effect. Magnesium glycinate in the evening can help counter stimulant-related sleep disruption. For heartburn relief, use a separate, appropriate product such as calcium carbonate antacids, an alginate (sodium alginate) formula, or DGL licorice, and take them apart from caffeine-containing products. Anyone with frequent reflux should limit stimulant intake and consult a healthcare provider.
Possible side effects: No major side effects reported.
Supplement Facts
Vitamin B6 3 mg · Vitamin B12 30 mcg · Choline 80 mg
| Vitamin B6 | 3 mg | |
| Vitamin B12 | 30 mcg | |
| Choline | 80 mg | |
| Thermogenic Fat Burning Complex† | 1,025 mg | † |
| Intensity and Focus Matrix | 76.1 mg | † |
| Appetite Suppression Carb Blocking Matrix† | 135 mg | † |
Other ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide.
Directions: As a dietary supplement, take 1 serving (2 capsules) 1 to 2 times daily. For best results, take 30-60 minutes before meals or your workout. Do not exceed more than 4 capsules per day.
Barcode (UPC) 850016689542 · Label source: Reverseagelab · Report a label change
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Members OnlyThe highest ranked for the same goal
Graded November 4, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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