InnovixLabs Vitamin D3 + K2 (with Vitamin A) Review

Vitamin D is at a full dose here, above the daily recommended limit, so members can take less. In people with type 2 diabetes, two large pooled analyses found that vitamin D modestly lowered fasting blood sugar, the long-term blood sugar marker and insulin resistance, most in people who were low in vitamin D ^[1][2]. In adults with prediabetes it cut the risk of developing diabetes by 15% over about 3 years ^[3]. In pregnant women it lowered pregnancy diabetes by about 36% ^[4]. However, a 5 year trial of 22,220 older adults found no significant drop in diabetes risk ^[5], and another pooled analysis in prediabetes found no change in fasting blood sugar ^[6]. Vitamin K2 is also at a full dose. A large review ranked vitamin K best for lowering the long-term blood sugar marker, though certainty was moderate to very low ^[7]. Trials in type 2 diabetes using 90 and 360 micrograms daily lowered blood sugar ^[8][9], but a review in mostly healthy people found no change ^[10]. Vitamin A, at a dose whose fit to studies is unclear, did not improve blood sugar in trials ^[11][12]. Animal and cell studies are never counted.

Vitamin D is the main ingredient here, and most of the panel recommends it or takes it, with all nine who spoke about it either recommending, using, or describing it favorably. They take it for brain and mood, bone health, immune function, and to correct low levels, and several aim for blood levels well above the usual cutoff, with targets such as 40 to 50, 50 to 80, or 60 to 100 ng/mL. Three panelists say they take 5,000 IU of D3 in the morning, and several say to take it with dietary fat for better absorption, with one advising against taking it with other supplements first thing in the morning. Vitamin K2 is the other main ingredient: several say to pair it with D3 so calcium goes to bones and away from arteries, and two panelists take 90 to 100 mcg in the morning. One panelist cautions that for most things there is no point supplementing unless you are deficient, and vitamin A is a smaller ingredient in this product that was only mentioned in passing as a fat-soluble vitamin that supports skin.