Kali Muscle Hyphy Mud 2.0 Extreme Tropical Fruit Review
Product Focus: Occasional Heartburn: Fast ReliefAlso covers:Digestion
Tier ⓘ
Tier 4 · Rank 13
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 13 within Tier 4 for Occasional Heartburn: Fast Relief; 22 of 26 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
15 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Biohacker Mentions
0 of 10
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Study, Trial or Testing Result Summary
Members Only6 human studies · 3 improved
6 human studies3 improved3 no effect12,902 people studied
No study tested this product, or any of its ingredients alone, for fast relief of occasional heartburn. Vitamin B6 is present at 1.5 milligrams, and its findings are mixed. A trial of 351 adults with acid reflux found that a blend of melatonin, vitamin B6 and other nutrients cleared symptoms in everyone after about 40 days, but the effect of vitamin B6 cannot be separated out [1]. One large diet study linked more vitamin B6 to lower odds of one type of reflux [2]. Another linked it to more reflux [3], and a third found no direct link [4]. In a two-week trial, a drink with 2 milligrams of vitamin B6 and other ingredients caused heartburn in 10 of 25 people [5]. Vitamin B12 is present at only 18 micrograms, far below the 1000 micrograms a day that lowered indigestion scores in a small study with no comparison group [6]. Vitamin B12 was also one part of the reflux blend above, so that result cannot be credited to it [1]. Niacin and the 3.8 gram Hyphy Blend have no human studies for this goal, and the contents of the blend are not listed. Animal and cell studies are never counted.
See all 6 studies →Hide the studies
- In 351 adults with acid reflux disease, a blend containing vitamin B6 plus melatonin and other nutrients led to complete symptom relief in all 176 people after 40 days, versus 65.7% of those taking a med, though the vitamin B6 effect cannot be separated from the other ingredients.Read the study on PubMed (16948779) →
- In 49 adults with constipation-type irritable bowel syndrome, a drink with 2 mg vitamin B6, inulin and menthol taken for 2 weeks improved bowel symptoms but caused noticeable heartburn in 10 of 25 people who drank it.[Using a multicomponent functional food in IBS patients with constipation a comparative controlled study].
- In a study of 11,690 people who had endoscopy and diet records, higher dietary vitamin B6 intake was linked to lower odds of non-erosive reflux disease, though this does not prove cause.Gender-specific Effect of Micronutrient on Non-erosive Reflux Disease and Erosive Esophagitis.
- In a case-control study of 150 women with reflux and 300 controls in Iran, higher dietary vitamin B6 intake was linked to higher odds of reflux disease.Dietary Vitamin B6 Intake and Gastroesophageal Reflux Disease: A Case-Control Study.
- In a cross-sectional study of 328 young adults, lower dietary vitamin B6 intake was linked to higher overall gastrointestinal symptom scores, but vitamin B6 intake was not directly linked to reflux status.Health cooking at home: can cooking skills reduce gastrointestinal symptoms, cross sectional study?
- In 34 people with Helicobacter pylori infection and low vitamin B12, 1000 mcg daily for 3 months shortened stomach emptying time and reduced dyspepsia scores, with no control group.The impact of B(12) treatment on gastric emptying time in patients with Helicobacter pylori infection.
Review Totals and Summary
Members OnlyWhat buyers say
Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.
Biohacker Summary
Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it
Vitamin B12, the main ingredient, gets mostly favorable views, with about half of the panel recommending it and a few more saying they use it. They take it to protect brain function, mood, energy, nerve coverings, hair color and, with B6 and folate, PMS. Preferred forms are methylcobalamin, including liposomal and micellar types, and one panelist suggests a sublingual form or injections for older people. One wants blood levels around 500, another advises testing first and supplementing only if low, and one warns to avoid B12 too close to bedtime because it enhances light's melatonin-suppressing effects. Niacin is a smaller ingredient in this product, and several recommend it for raising NAD, while one panelist stopped prescribing it after trials showed little benefit.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Vitamin B12 · neutral
- Mentions that one can of sardines provides 348% of the daily Vitamin B12.
- Dr. Berg states that when nutrients like vitamin B12 are too low, fatigue and weakness can follow.
- States that vitamin B6 is needed to absorb magnesium.
- States that expensive NAD+ supplements only turn into $5 niacin in the body and that research has shown niacin can actually raise NAD levels in the blood 5 to 8 times their baseline levels.
- Recommends cheap flush niacin, stating that it outperforms expensive NAD supplements and even IV drips in raising NAD levels in the blood.
- Dr. Berg lists pyridoxine hydrochloride as a synthetic vitamin to avoid.
- Recommends taking the natural form of vitamin B12, methylcobalamin, to support nerve regeneration, myelin production, and nerve growth factors.
- Notes that Vitamin B12 is intimately involved in the nervous system and may be behind sciatica and carpal tunnel syndrome.
- Recommends taking the active form of vitamin B6, pyridoxal-5-phosphate (P5P), for its benefits to the nervous system, including building the myelin sheath and protecting sensory nerve integrity.
- Notes that Vitamin B6 is intimately involved in the nervous system and may be behind sciatica and carpal tunnel syndrome.
- States that cheap niacin, which creates a flush, ends up more in the blood than expensive NAD versions, suggesting it is more effective for unhealthy individuals.
- Niacin is linked to several areas of physical and mental health. Studies have looked at its effects on cholesterol, the heart, liver health, schizophrenia, depression, and bipolar disorder.
- Recommends taking vitamin B12 if on a med.
- Briefly mentions Vitamin B12 in relation to neuropathy.
Thomas DeLauer · Vitamin B12 · recommends
- Recommends Vitamin B12 for mental health and mood, explaining its role in myelination and neurotransmitter production. They specifically recommend a liposomal and micellar form of methylcobalamin B12 for better absorption and to avoid toxicity.
- Uses niacin as part of their detoxification protocol, taking enough to flush about half an hour before a sauna session.
- Mentions that a single serving of sardines provides vitamin B12 at something like three to four times the daily needs.
- Recommends taking methylcobalamin as a methylated form of B vitamin for mitochondrial function.
- Discusses niacin as an essential vitamin involved in NAD production and known for its flushing effect as a vasodilator. He also mentions its role as an agonist for GPR109A receptors, which could potentially block fat mobilization.
- Recommends ensuring adequate vitamin B6 intake, as it is a required cofactor for cells to use absorbed magnesium and improves central nervous system relaxation when combined with magnesium.
- Recommends vitamin B6 to support GABA production and find balance for mental clarity.
- Notes that Niacin or Vitamin B3 can be good, but taking a lot can increase methylation, so it needs to be balanced.
- Mentions B12 as a critical B vitamin for reducing homocysteine.
- Warns that taking high doses of Niacin can put a lot of burden on the methylation system.
- Advises against taking vitamin B12 if one's diet already provides enough, suggesting a B complex or liver capsule instead for B vitamins.
- Was taking Vitamin B12 with fat burner injections, which he later stopped cold turkey, leading to a period of intense emotional and hormonal imbalance.
- Warns that high levels of supplemental vitamin B12 are a risk factor for insomnia, as it is an energy-building supplement, and advises taking it in the morning or lowering the dose.
- Recommends occasionally taking a little bit of niacin, a B3 vitamin, as it is a great precursor for NAD and helps with energy manufacturing.
Dr. Mark Hyman · Vitamin B6 · uses
- Optimized a child's nutrient status with vitamin B6, as the child had low B6 levels.
- Explains that pellagra, which killed 100,000 Americans, was a niacin deficiency, a B vitamin.
- States that vitamin B12 is a nutritional deficiency that impacts mental health.
- Recommends vitamin B6 with folate and B12 as supplements with strong evidence for PMS.
- Recommends vitamin B12 with vitamin B6 and folate as supplements with strong evidence for PMS.
- Believes that if functional testing is done to replete deficiencies like vitamin D and B12 before someone stops their medication, withdrawal symptoms can be completely eliminated.
- Mentions that repletion of vitamin B12 can help safely withdraw someone from meds and that simple vitamin B12 deficiencies are important to address in a depression workup.
- Lists Vitamin B12 as important for nerve health and energy.
- Lists niacin as a B vitamin cofactor that helps mitochondrial function.
- Mentions vitamin B12 as a core nutrient required for methylation, noting that deficiencies can lead to various health issues.
- Recommends supplementing with Vitamin B12 for hair follicle health and growth, especially for vegans, as many people are deficient.
- Recommends checking vitamin B12 levels as a first step before taking any supplements.
- Warns that meds (meds) block the absorption of vitamin B12, which requires stomach acid to be absorbed. Long-term B12 deficiency can lead to depression, neurological problems, and dementia.
- States that Vitamin B6, at 50 to 100, is important for estrogen metabolism.
Ben Greenfield · Vitamin B12 · recommends
- Recommends getting vitamin B12 tested and supplementing if deficient, as B12 deficiency can cause damage to the myelin coating around nerves, including cochlear nerves, and improve tinnitus severity scores.
- States that Nrf2 activators, when combined with something like niacin, may have a good effect on plaque progression.
- Mentions nicotinamide as an ingredient found in many NAD products and notes that niacinamide and nicotinamide are structurally the same.
- Believes the niacinamide approach, along with the NAMPT/salvage pathway angle, is underrated and deserves more attention.
- Mentions niacin as a natural approach that might be good for plaque regression.
- Notes that 10X Health System's methylene blue tablets plus light stack supports energy and recovery at the cellular level by promoting healthy metabolism through niacinamide.
- Uses Niacinamide as a clean building block for NAD+ as part of NAD Regen.
- Recommends priming the skin with niacinamide to reduce hyperpigmentation, noting its effectiveness in reducing hyperpigmentation by 50% in an ex-girlfriend's laser burn.
- Recommends Vitamin B6 for the conversion of tryptophan to serotonin and then melatonin in the pineal gland.
- Mentions that a deficiency in niacin could lead to handling far less alcohol due to its role in detoxifying acetaldehyde.
- Mentions niacin as a supplement that can really heat the body up, leading to more sweating and detox.
- Has been impressed with and uses Scandinavian Biolabs Bio-Pilen shampoo, conditioner, and serum, which contain ingredients like niacinamide, aloe vera, an amino acid complex, vanillyl butyl ether, zinc PCA, and Capilia Longa to help with hair growth, strength, and recovery.
- He recommends Vitamin B12, especially for kids on a vegan or vegetarian diet, as it is essential for nervous system development.
- Mentions that blood testing for an energy crisis would include nutritional things like a vitamin B12 level.
Dave Asprey · Vitamin B12 · recommends
- States that Vitamin B12 is extremely important for every kind of brain function and recommends ensuring B12 levels are optimal, around 500, not just barely above normal.
- Recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish, or from supplements.
- Dave Asprey recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish.
- Notes that niacin has been a standard longevity ingredient since the 1990s.
- Dave discusses how niacinamide compares as an NAD precursor.
- Dave explains that niacinamide is an old-school way to mildly elevate NAD levels, and it was the only way to raise NAD in the very early days.
- Used niacin for a while to address plaque in his arteries and high LP(a), but stopped because it caused high liver values and made him feel unwell, despite dropping his LP(a).
- Mentions Vitamin B6 as playing a role in methylation pathways.
- Recommends taking vitamin B12 if one has a deficiency.
- States that he has been using niacinamide for up to 20 years for longevity.
- Mentions that niacinamide is the very oldest way of raising NAD.
- Likes niacinamide, which is a precursor to NR and NMN.
- Warns that the synthetic form of vitamin B6 found in almost all multivitamins and energy drinks binds to B6 receptors for a thousand days, making them unavailable for the beneficial form.
- Takes niacinamide, along with NR and NMN, for longevity, believing it provides similar performance for NAD levels.
Siim Land · Vitamin B12 · uses
- Created Microvitamin, a supplement that bundled all the supplements he was taking, to help fund his a med trial.
- States that vitamin B12 deficiency is the most common reason for premature graying of hair and recommends fixing B12 status if it is deficient, as it gives a greater likelihood of reversing gray hair.
- Suggests that in the mornings, NAD supplements like niacinamide can help kickstart the circadian rhythm.
- Recommends Niacinamide for skin protection, explaining it works partly through NAD metabolism that the body uses against DNA damage and is found in protein sources.
- Mentions that only specific therapies like niacin can meaningfully reduce Lp(a).
- Notes that Niacin notoriously raises HDL cholesterol, but this increase does not lower the risk of heart disease events, and while it can be good in many cases, very high doses can affect liver function.
- Recommends niacin as a much cheaper and equally effective NAD booster compared to NMN and NR.
- Warns that niacin, an NAD precursor, can shorten sleep.
- Recommends taking 100-300 milligrams of niacin before a sauna session, as part of the Hubert protocol, to enhance sweating, vasodilation, and potentially detoxification and cardiovascular benefits.
- Warns that Niacin, especially at high doses like 2000 mg per day, can disrupt sleep by increasing energy levels too high, causing flushing, and reducing deep sleep while increasing shallow non-REM sleep.
- Discusses Niacinamide as a form of vitamin B3 that can increase NAD+ levels, but notes it's not as effective as NMN or NR for longevity and can cause flushing.
- Mentions that Niacin is known to raise HDL cholesterol, but this does not lower the risk of heart disease events. He considers it a good supplement for many cases, noting that very high doses can affect liver function, and its benefits mostly stop at increased HDL cholesterol.
- Mentions that insufficient vitamin B6 can raise prolactin levels.
- Recommends B12 for vegans, noting it is a standard vitamin found in animal products.
Andrew Huberman · Vitamin B12 · neutral
- States that a deficiency in vitamin B12 can be terrible and lead to chronic fatigue-like syndromes, as many parts of mitochondria require B vitamins.
- Recommends taking methyl B12 as part of methylated B vitamins to lower homocysteine levels and reduce cardiovascular risk.
- Has been taking AG1 for over 10 years, once and often twice every day, to ensure he gets all necessary vitamins, minerals, probiotics, and adaptogens, considering it a nutritional insurance policy.
- Does not supplement B6 due to evidence that overs-supplementing vitamin B, especially B6, is problematic because of peripheral nerve damage.
- Reviews data on ingesting or topically applying niacinamide to improve skin's youthfulness and appearance, including reducing wrinkles, sagging, and pore size.
- Recommends niacinamide supplementation, a form of Vitamin B3, at 500 milligrams twice per day for a total of 1 gram daily, to increase ceramide production, improve skin moisture, reduce inflammation, balance oil production, and reduce the appearance of clogged pores and hyperpigmented spots.
- Has been taking AG1 since 2012 to ensure he gets enough vitamins, minerals, Prebiotic fiber, and other nutrients typically found in fruits and vegetables, providing nutritional insurance.
- Andrew Huberman started drinking AG1 in 2012 and still drinks it once or twice a day because it provides all his foundational nutritional needs, ensuring proper amounts of vitamins, minerals, probiotics, and fiber for optimal mental health, physical health, and performance.
- Notes that some people are exploring the use of P5P, a metabolite of vitamin B6 known to suppress prolactin, as a way to buffer the post-MDMA crash, though there are no human data yet.
- Recommends the consumption of B12 and other B vitamins, especially folate, as it has been shown to partially decrease cancer risk in people who ingest alcohol, though it does not completely offset it.
- Started taking AG1 in 2012 and still takes it once or twice a day because it covers foundational vitamin, mineral, and probiotic needs, and supports immune system function and a healthy gut microbiome.
- Recommends P5P, which is vitamin B6, as a dopamine agonist to help with low drive and motivation.
- He has been using Athletic Greens for over a decade to cover his vitamin and mineral bases and support his gut microbiome, immune system, gut-brain axis, and mental functions.
- Described how some people take vitamin B6 to reduce prolactin levels and thereby reduce the duration of the refractory period, but he is not suggesting anyone do this.
Dr. Rhonda Patrick · Vitamin B12 · warns
- Warns that Vitamin B12 enhances light's melatonin-suppressing effects and should be avoided too close to bedtime.
- States that NAD can be synthesized from the three forms of niacin, also known as vitamin B3, found in foods like lean meats, legumes, and veggies.
- Notes that a med can cause vitamin B12 deficiency, especially as absorption decreases with age, and suggests a sublingual form or B12 injections for older individuals.
- Discusses the origin of Vitamin B12, suggesting it's a microorganism that propagates in the soil and that animals get it from eating dirt, which is why it's less available in modern, sanitized plant foods.
- Dr. Patrick states that people with a specific gene polymorphism in the NPF3 gene, which affects vitamin B6 levels, may need to increase their dietary intake of B6 and/or supplement with vitamin B6.
- Vitamin B6 can suppress the production of Advanced Glycation End products.
- Describes a study where female mice fed a diet high in B vitamins, folic acid, and vitamin B12 three weeks before pregnancy had offspring that no longer had yellow fur and were not predisposed to obesity and cancer.
- Dr. Rhonda Patrick explores vitamin B12 and autism risk.
- She takes methyl B12 as part of her Thorne multivitamin, which helps keep her homocysteine levels below 9 micromoles per liter.
- Describes a study where female mice fed a diet high in B vitamins, folic acid, and vitamin B12 had offspring that silenced a gene predisposing them to obesity and cancer.
- Supplements with vitamin B12, but also notes many of the foods he eats are fortified with it, and his levels are fine.
- Dr. Rhonda Patrick explores high-dose vitamin B6.
- Notes that very high doses of vitamin B6 can overcome a specific mutation in the ornithine aminotransferase enzyme, preventing progressive blindness.
Bryan Johnson · Vitamin B12 · uses
- States that Blueprint essential capsules and soft gels are packed with key vitamins and minerals needed for strong bone health.
- Recommends Niacinamide as a supplement for skin health, noting it is in the Blueprint stack.
- He uses Niacinamide, found in serums or moisturizers, morning and night, and takes 15 mg in Blueprint Essential Capsules.
Peter Attia · Vitamin B12 · neutral
- Notes that deficiencies in certain vitamins and minerals, such as B12, can be a cause of hair loss in women.
- Peter Attia's AVIA Skincare vitamin C serum also contains niacinamide, which is useful to apply to the skin right after washing.
- Used to prescribe niacin to many patients, primarily to raise HDL, lower APO B, triglycerides, LDL, and LP(a), but stopped after clinical trials showed minimal or disappointing effects on reducing cardiovascular events.
- Notes that niacin lowers LP little a but was not shown to have clinical benefit in outcome studies, and they are not currently using it.
- Recalls that a flush from niacin typically occurred with doses of a few grams.
- Explains that niacin does reduce Lp(a) levels, increase HDL, and lower triglycerides, but two large cardiovascular outcome trials have shown no cardiovascular benefits and many side effects, such as flushing. He concludes that the cost-to-benefit ratio does not support its use.
- He dives into data on the possible treatments for lowering Lp(a) such niacin, meds, and PCSK9 inhibitors.
- States that niacin is a dead drug and is not recommended by any guidelines, though some still selectively use it for Lp(a).
- Warns against taking high doses of nicotinamide (a form of niacin/vitamin B3) because it is an effective inhibitor of sirtuins, which are enzymes one wants to keep active for the purpose of raising NAD.
- Peter Atia notes that some people still argue niacin makes sense because it lowers LP little-a, but he advises against it, stating that it has a weak lowering effect of about 20% and that he knows many lipidologists who would not use it.
- Warns against niacin, stating that it causes acanthosis nigricans, worsens insulin resistance, and has numerous other side effects, despite lowering apoB. He recounts a patient who experienced a severe pruritic reaction, thinking he was going to die.
- Explains that when a person is not responding to traditional B vitamins, they will step it up and give them methylcobalamin B12.
- Notes that Ryan Lochte was suspended for a doping rule violation after a social media post showed him taking vitamin B12 in an illegal way, by IV infusion.
RAL Summary
Members OnlyTier 4 for Occasional Heartburn: Fast Relief
Evidence is thin and conflicting: the vitamin B6 studies disagree, none tested quick heartburn relief, and no reviews were counted, so tier 4 fits.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 3 of the 6 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Digestive system
Combine with: Combine with a healthy diet and lifestyle.
Possible side effects: In one trial, a drink with vitamin B6, inulin and menthol caused noticeable heartburn in 10 of 25 people. No reviews were available to report other effects.
Supplement Facts
Niacin 12 mg · Vitamin B6 1.5 mg · Vitamin B12 18 mcg
Supplement Facts
Serving Size 4.8 Gram(s)
Servings Per Container 30
Amount Per Serving% Daily Value
| Niacin | 12 mg | |
| Vitamin B6 | 1.5 mg | |
| Vitamin B12 | 18 mcg | |
| Hyphy Blend | 3.8 g | † |
† Daily Value not established.
Other ingredients: Citric Acid, Natural and Artificial flavoring, Silica, Sucralose, Calcium Silicate, Acesulfame Potassium, FD&C Red #40.
Directions: Caution: Take one scoop max
Label source: NIH label database · Report a label change
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Graded November 10, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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