Market America Probiotics10 Review
Tier ⓘ
Tier 2 · Rank 35
Tier 2 · Researched. Human studies show improvement in an aging-related function or a specific goal, and the reviews agree. Rank 35 within Tier 2 for Healthy Aging; 49 of 215 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
68 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
95% of 3,700
Biohacker Mentions
0 of 10
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Study, Trial or Testing Result Summary
Members Only45 human studies · 34 improved
45 human studies34 improved2 no effect2,619 people studied
This product contains a 300 mg proprietary probiotic blend, estimated at about 15 billion live bacteria, which is above the amount used in studies. The exact strains are not disclosed, so the studies below test other probiotic products, not this blend. In 119 adults aged 65 to 85, a probiotic taken for 12 weeks improved leg strength and endurance and lowered inflammation compared with placebo, though muscle mass did not change [1]. In older men with lung disease and in men with Alzheimer's disease, a daily multistrain probiotic for about four months improved grip strength, walking speed, inflammation and oxidative stress [2][3]. In 240 adults, probiotic yoghurt lowered oxidative stress [4]. In 46 adults over 60, a probiotic blend for 6 months slowed the loss of telomere length, a marker of cell aging [5]. A pooled analysis found probiotics and prebiotics improved skin hydration [6]. These studies show better aging markers. None shows that a probiotic by itself reverses biological age. Animal and cell studies are never counted.
See all 45 studies →Hide the studies
- A pooled analysis of 61 studies of dietary interventions found that prebiotics and probiotics improved skin hydration compared with controls.Dietary interventions in skin ageing: a systematic review and meta-analysis.
- A review of 21 randomized trials found limited supportive evidence that these products reduce oxidative stress; probiotics in dairy products helped, but probiotic supplements had no effect.Prebiotics, Prosynbiotics and Synbiotics: Can They Reduce Plasma Oxidative Stress Parameters? A Systematic Review.
- In two placebo-controlled trials of 240 adults in total, yoghurt with a probiotic strain lowered oxidised blood fats and oxidative stress and improved blood sugar in overweight people, and lowered LDL cholesterol in people with normal weight.Impact of Lactiplantibacillus plantarum Inducia on metabolic and antioxidative response in cholesterol and BMI variable …
- In 119 adults aged 65-85, 12 weeks of live or heat-treated PS23 improved lower limb muscle strength and endurance and lowered inflammation markers CRP and IL-6 compared with placebo, without changing muscle mass.Enhancement of Lower Limb Muscle Strength and Reduction of Inflammation in the Elderly: A Randomized, Double-Blind Clini…
- In 115 osteoarthritis patients aged 60-75, one daily multistrain probiotic capsule for 16 weeks improved walking speed, grip strength, physical performance, pain and lowered inflammation compared with baseline.Probiotics improve functional performance in patients with osteoarthritis: a randomized placebo-controlled clinical tria…
- In 105 men with Alzheimer's disease, one daily probiotic capsule for four months improved grip strength, walking speed and physical performance and reduced markers of inflammation and oxidative stress.Probiotics combat sarcopenia by restoring gut integrity in Alzheimer's disease.
- In 104 older men with COPD, a daily multistrain probiotic for 16 weeks improved grip strength, walking speed and physical performance and lowered inflammation and oxidative stress markers, though sarcopenia rates did not significantly fall.A multistrain probiotic improves handgrip strength and functional capacity in patients with COPD: A randomized controlle…
- In 97 healthy seniors, six months of a probiotic blend lowered the inflammation marker CRP more than placebo and increased gut bacteria linked to beneficial fatty acids.Impact of a probiotic diet on well-being of healthy senior: THE PROBIOSENIOR PROJECT.
- In 90 people with mild to moderate Alzheimer's disease, 12 weeks of one of two single-strain probiotics improved blood markers of oxidative stress and inflammation compared with placebo.The effects of probiotic supplements on oxidative stress and inflammation in subjects with mild and moderate Alzheimer's…
- In 90 people with fixed braces, a probiotic mouthwash over 9 months lowered cavity-causing bacteria and a saliva marker of DNA oxidative damage (3.8 to 2.42 ng/mL), but less than propolis or fluoride mouthwashes; there was no placebo group.Comparative evaluation of propolis, fluoride and probiotic mouthwashes on streptococcus mutans and oxidative stress in f…
- In 90 women with polycystic ovary syndrome, 8 weeks of two probiotic strains raised antioxidant capacity and lowered malondialdehyde and C-reactive protein compared with placebo.Effects of supplementation with two probiotic strains (Lactobacillus helveticus and Bifidobacterium longum) on hormonal …
- In 90 people with relapsing-remitting multiple sclerosis (55 completed), four months of probiotics changed oxidative stress markers no differently than placebo.The effects of probiotics supplementation on serum markers of oxidative stress in relapsing-remitting multiple sclerosis…
- In 80 adults, a daily drink with a probiotic bifidobacteria strain plus inulin fiber for 12 weeks improved overall thinking and attention scores compared with placebo.Effect of Continuous Ingestion of Bifidobacteria and Dietary Fiber on Improvement in Cognitive Function: A Randomized, D…
- In 74 adult smokers, a daily multi-strain probiotic for 12 weeks lowered blood sugar, some blood fats and inflammation marker levels compared with placebo, but did not change oxidative stress markers, anxiety, depression or nicotine dependence.The effect of probiotics on anxiety, depression, nicotine dependence, and metabolic biomarkers in smokers: a randomized …
- In 70 adults on methadone maintenance, 1.8 billion CFU of probiotics daily for 12 weeks improved depression scores and lowered inflammation and raised antioxidant levels compared with placebo.Read the study on PubMed (35685534) →
- In 70 adults with knee osteoarthritis taking Saccharomyces boulardii for 12 weeks, pain fell more than with placebo and blood markers of inflammation and oxidative stress also dropped.Saccharomyces boulardii improves clinical and paraclinical indices in overweight/obese knee osteoarthritis patients: a r…
- In 67 overweight or obese older men taking probiotic-fortified kefir for 8 weeks, depression scores improved more than with regular kefir and total antioxidant capacity rose, but appetite, inflammation and other oxidative markers did not differ from placebo.The effect of probiotic-fortified kefir on depression, appetite, oxidative stress, and inflammatory parameters in Irania…
- In 64 pregnant women with gestational diabetes, an 8-week four-strain probiotic capsule lowered C-reactive protein and tumor necrosis factor alpha and improved several oxidative stress markers compared with placebo.Effect of probiotic supplements in women with gestational diabetes mellitus on inflammation and oxidative stress biomark…
- In 60 adults on dialysis with diabetes, a three-strain probiotic capsule for 12 weeks lowered blood sugar, long-term blood sugar marker, inflammation and oxidative stress compared with placebo.Probiotic supplementation in diabetic hemodialysis patients has beneficial metabolic effects.
- In 60 women with polycystic ovary syndrome, 12 weeks of probiotic supplements compared with placebo lowered C-reactive protein and a blood marker of lipid damage and raised total antioxidant capacity, with mixed effects on hormones.Effects of Probiotic Supplementation on Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women With…
- In 60 people with diabetic kidney disease, a daily probiotic for 12 weeks lowered blood sugar, insulin resistance, inflammation and a lipid-damage marker, and raised glutathione compared with placebo.Metabolic and genetic response to probiotics supplementation in patients with diabetic nephropathy: a randomized, double…
- In 57 adults with age-related macular degeneration taking a probiotic capsule for 8 weeks, antioxidant capacity improved and malondialdehyde fell compared with placebo, but clinical eye signs did not change.Therapeutic effect of probiotics on metabolic indices and clinical signs in age-related macular degeneration.
- In 52 men with low sperm counts or poor sperm movement, 500 mg of probiotics daily for 10 weeks improved sperm count and movement and lowered oxidative stress and inflammatory markers compared with placebo; this paper has been retracted, so the result is unreliable.Probiotic effects on sperm parameters, oxidative stress index, inflammatory factors and sex hormones in infertile men.
- In 50 people with Parkinson's disease, 12 weeks of a daily probiotic capsule lowered inflammatory gene activity in immune cells compared with placebo.The Effects of Probiotic Supplementation on Gene Expression Related to Inflammation, Insulin and Lipid in Patients with …
- In 50 adults with high cholesterol, Lactobacillus paracasei TISTR 2593 taken for 90 days lowered LDL cholesterol, a lipid-damage marker and an inflammatory signal, and raised adiponectin compared with placebo.Safety and Effects of Lactobacillus paracasei TISTR 2593 Supplementation on Improving Cholesterol Metabolism and Atheros…
- In 48 older Korean adults, an 8-week balanced diet improved several blood markers, and adding probiotics mainly changed gut bacteria composition rather than clearly improving blood markers.Effects of a Balanced Diet and Probiotics on Blood Biomarkers and Gut Microbiota in the Elderly: A Community-Based Inter…
- In 46 adults, a skin ointment with live Lactiplantibacillus plantarum LB244R used twice daily for 56 days improved skin thickness, density, elasticity, hydration and crow's feet wrinkles more than a placebo ointment.A proof of concept: Clinical anti-aging efficacy and safety of Lactiplantibacillus plantarum LB244R® applied topically i…
- In 46 adults aged 60 and older taking a probiotic blend or placebo for 6 months, the probiotic group lost telomere length more slowly than the placebo group.Probiotic Supplementation in Aged Human Subjects Counteracts Leukocyte Telomere Attrition Rate.
- In 44 adults with metabolic syndrome eating 300 g of synbiotic yogurt daily for 12 weeks, antioxidant enzyme levels rose and total oxidant status fell compared with regular yogurt.Consumption of a new developed synbiotic yogurt improves oxidative stress status in adults with metabolic syndrome: a ra…
- In a pilot randomized trial of 43 healthy men aged 50 to 72, an 8-week program of diet, sleep, exercise, relaxation and supplemental probiotics and plant nutrients lowered epigenetic age by about 3.2 years compared with a no-intervention control group; the probiotic part was not tested on its own.Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial.
- In 42 adults with rheumatoid arthritis, a five-strain probiotic taken for 60 days lowered inflammatory markers and improved antioxidant measures compared with placebo, though joint disease scores did not change.Mixture of probiotics reduces inflammatory biomarkers and improves the oxidative/nitrosative profile in people with rheu…
- In 40 people with inflammatory bowel disease, probiotics taken for 90 days improved oxidative stress readings compared with placebo, with antioxidant levels rising in the probiotic group.Probiotics Efficacy on Oxidative Stress Values in Inflammatory Bowel Disease: A Randomized Double-Blinded Placebo-Contro…
- In 40 people with multiple sclerosis, Saccharomyces boulardii taken for four months lowered inflammation and raised antioxidant capacity compared with placebo, and also reduced pain, fatigue and improved quality of life.The effect of probiotic supplementation on the clinical and para-clinical findings of multiple sclerosis: a randomized c…
- In 40 adults with mild Alzheimer's disease, taking Escherichia coli Nissle 1917 capsules for six weeks reduced oxidative stress, inflammatory markers and bacterial endotoxin in the blood and improved memory test scores compared with placebo.Effect of the probiotic Escherichia coli Nissle 1917 on serum levels of NADPH oxidase-2 and lipopolysaccharide in patien…
- In 38 people with bipolar disorder, 8 weeks of adjunctive probiotics did not change inflammation or oxidative stress markers compared with placebo.The Effect of Adjunctive Probiotics on Markers of Inflammation and Oxidative Stress in Bipolar Disorder: A Double-blind,…
- In 28 healthy adults in a crossover trial, Leuconostoc mesenteroides VITA-PB2 taken before alcohol reduced oxidative stress markers compared with placebo.Efficacy of Probiotic VITA-PB2 from Fermented Foods on Alcohol Consumption and Hangover Symptoms: A Randomized, Double-B…
- In a pilot study of 15 pregnant women, probiotics changed DNA methylation at obesity-related genes in mothers and their children, but the abstract does not show a clear health benefit.The impact of probiotic supplementation during pregnancy on DNA methylation of obesity-related genes in mothers and thei…
- After a set of maximal jumps that damages muscle, 6 weeks of live Lactobacillus paracasei PS23 helped muscle strength recover faster and lowered muscle damage and inflammation markers compared with placebo.Live and Heat-Killed Probiotic Lactobacillus paracasei PS23 Accelerated the Improvement and Recovery of Strength and Dam…
- In elite athletes taking a multi-strain probiotic for one week in a placebo-controlled crossover trial, treadmill exercise time and an antioxidant enzyme (superoxide dismutase) improved, but maximal oxygen uptake, lactate removal and a marker of oxidative damage (malondialdehyde) did not change.The Effects of Multi-Strain Probiotic SLAB51 Intake on Aerobic Performance and Oxidative Stress Responses in Elite Athle…
- In healthy volunteers, a synbiotic lowered some oxidative stress markers in women and men, but the change in an antioxidant enzyme was not significant.Assessment of human 4-hydroxynonenal, 8-isoprostane concentrations and glutathione reductase activity after synbiotics a…
- In 125 healthy older adults, an 8-week balanced diet lowered inflammation markers, and adding the VSL#3 probiotic blend to the diet changed gut bacteria balance but did not clearly add further reductions in inflammation.Impact of diet and nutraceutical supplementation on inflammation in elderly people. Results from the RISTOMED study, an …
- In an exploratory study of 21 people, a probiotic ointment applied twice daily for 56 days improved skin hydration, elasticity, firmness and wrinkles, but there was no placebo group, so the result cannot be confirmed as caused by the ointment.Topical Lactiplantibacillus plantarum LB244R® ointment alleviates skin aging: An exploratory trial.
- In uncontrolled 90-day use of kefir fermented milk by people with Alzheimer's disease, memory and thinking tests improved and markers of inflammation and oxidative stress fell.Oxidative Stress and Dementia in Alzheimer's Patients: Effects of Synbiotic Supplementation.
- In a study of aged mice and people with sarcopenia (age-related muscle loss), the probiotic Probio-M8 improved muscle function and physical performance, with no dose or duration reported in the abstract.Bifidobacterium animalis Probio-M8 improves sarcopenia physical performance by mitigating creatine restrictions imposed …
- In a case series of six women, an 8-week program of diet, sleep, exercise, coaching and supplemental probiotics and phytonutrients lowered DNA methylation biological age in five of six participants, by an average of 4.6 years across the group, though there was no control group.Potential reversal of biological age in women following an 8-week methylation-supportive diet and lifestyle program: a c…
Review Totals and Summary
Members Only3,700 reviews · 95% positive
3,700 reviews · Google Shopping 3,700
95% positive0% neutral5% negative
Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.
Biohacker Summary
Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it
Our biohacker panel has not discussed this product’s ingredients yet.
RAL Summary
Members OnlyTier 2 for Healthy Aging
Many placebo-controlled human trials of probiotic blends show improvements in aging markers such as strength, inflammation, oxidative stress and telomere length [1][5]. With 3700 reviews, 95% of them positive, this meets tier 2.
Where the evidence disagrees: 2 of the 45 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Digestive system, Immune system, Muscular system, Skin
Combine with: Combine with a healthy diet and lifestyle.
Possible side effects: No major side effects reported.
Supplement Facts
Total Carbohydrates 1 g · Proprietary Probiotic Blend 300 mg
Supplement Facts
Serving Size 1 Tablet(s)
Servings Per Container 30
Amount Per Serving% Daily Value
| Total Carbohydrates | 1 g | |
| Sodium | 20 mg | |
| Proprietary Probiotic Blend | 300 mg | † |
† Daily Value not established.
Other ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Pectin, Stearic Acid, Guar Gum, Turmeric.
Directions: Directions for use: As a dietary supplement, take 1 tablet with water prior to the first meal of the day, or as directed by your healthcare provider.
Barcode (UPC) 848570006752 · Label source: NIH label database · Report a label change
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Graded November 14, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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