Medieval Research Red Wedding Review
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Study, Trial or Testing Result Summary
Members Only1 human studies · 1 improved
No study in people has tested this product. Its best-studied ingredient, GW501516, is at 12.5 milligrams, above the 10 milligrams used in its one human trial. In that small two-week trial, 18 overweight men took it or a placebo. It lowered blood fats called triglycerides by 30%, liver fat by 20%, and a urine marker of oxidative stress, a type of cell damage linked to aging, by 30%. Muscles also burned more fat [1]. The trial was very short and small and did not measure biological age [1]. The second ingredient, 5-aminoimidazole-4-carboxamide, has been studied only in animals and cells, and it is unclear whether this label's 20 milligram dose matches the studied forms. In mice and rats it protected muscle, liver, heart and nerves and helped cell energy production [2][3][4][5]. But it gave little benefit after a major muscle injury in mice [6], and very old mice responded much less to its blood sugar lowering effect than young mice [7]. The third ingredient, ostarine, has no studies for this goal in the data we have. Overall, there is no proof that this product reverses aging or repairs cells in people. Animal and cell studies are never counted.
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- In 18 moderately overweight men (6 per group), 10 mg daily of GW501516 for 2 weeks lowered triglycerides by 30%, liver fat by 20% and a urinary marker of oxidative stress by 30% compared with placebo, and increased fat burning in muscle.Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormaliti…
Review Totals and Summary
Members Only14 reviews · 95% positive
Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.
Biohacker Summary
Members Only0 of 10 recommend it
Three of the ten panelists spoke about GW501516, the main ingredient, and their views split. One of them, who has taken it in the past as part of a stack, recommends it for growing new mitochondria and raising a key energy signal, calling it the closest thing to exercise in a pill, though he notes sports bodies ban it. The other two urge caution: one calls it a research drug not meant for human consumption, with study discontinued, and warns that excessive long-term doses could switch on pathways linked to cancer, while the other is not a fan and fears it could grow tumors if cancer cells are already present. No doses or preferred forms were given, and no one named a pairing beyond the stack mention. Ostarine is a smaller ingredient in this product, and the panelists who discussed it ranged from one who tried it and noticed nothing and stopped, to another who warned of hormone, cholesterol and liver effects.
See all 4 biohackers →Hide the biohackers
Dave Asprey · GW501516 · uses
- Mentioned taking GW501516 back in the day as part of his SARM stack.
- Recommends GW501516, also known as cardarine, for raising PGC1 alpha and increasing mitochondrial density, stating it's banned by the International Olympic Committee, which means it works.
- Mentions GW501516, also known as Cardarine, as a compound that causes new mitochondria to grow, makes mitochondria work better, and raises PGC1 Alpha, calling it the closest thing to exercise in a pill.
- Mentions GW501516, also known as Cardarine, as a powerful PPAR gamma activator that causes mitochondrial growth, but notes it is banned by the World Anti-Doping Association.
- Mentions GW501516 (Cardarine) as one of his two favorite Nrf2 inducers or longevity drugs, describing it as 'exercise in a pill' that causes new mitochondria growth.
- States he has used GW501516 for years, noting it increases the number and efficiency of mitochondria and raises pgc1 Alpha.
- Mentions GW501516, also known as Cardarine, as a SARM that causes the body to grow more mitochondria.
Ben Greenfield · GW501516 · neutral
- Discusses GW501516, noting that initial cancer concerns were debunked due to flawed studies. He explains that it works on multiple pathways, and excessive, long-term dosages could potentially activate pro-cancer pathways.
- Clarifies that GW501516 is not a SARM but a PPAR delta agonist that improves endurance, but warns that it is a research drug, not for human consumption, and its study has been discontinued for various reasons.
Thomas DeLauer · GW501516 · warns
- Is not a big fan of GW501516, advising caution due to its newness and potential dangers, such as promoting heavy IGF-1 LR3 responses that could grow tumors if existing cancer cells are present.
- Warns that Ostarine can cause virilization in females, decrease testosterone significantly in males without TRT/HRT, and lead to high bad cholesterol, low good cholesterol, and high liver enzyme levels.
- Has used Ostarine over the years to try and biohack his growth hormone production but didn't notice anything.
- Notes that Ostarine (MK2866), now named Enobosarm, is continually progressing in clinical literature for Androgen receptor-responsive breast cancer and potentially prostate cancer.
Peter Attia · Ostarine · neutral
- States that Ostarine, also known as enobosarm, is probably the most well-known SARM, often used by women to achieve a physique for competition without virilization, though it has not been FDA approved.
RAL Summary
Members OnlyTier 4 for Healthy Aging
Tier 2 needs over 100 reviews, but this product has only 14, and the only human evidence is one tiny two-week study of aging markers, so the evidence is thin. So it is graded Tier 4, lower than the rules alone gave.
- Emerging: not enough evidence to rank higher yet.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Metabolic system, Liver, Muscular system, Cardiovascular system, Nervous system
Combine with: Combine with a healthy diet and lifestyle.
Possible side effects: No major side effects reported.
Supplement Facts
5-Aminoimidazole-4-carboxiamide 20 mg · 2- phenyl)-5-thiazolyl)methyl)thio)phenoxy)-acetic acid 12.5 mg · 3- -N- phenyl)-2-hydroxy-2-methylpropanamide) 20 mg
| 5-Aminoimidazole-4-carboxiamide | 20 mg | † |
| 2-(2-methyl-4(((4-methyl-2-(4-(trifluoromethyl)phenyl)-5-thiazolyl)methyl)thio)phenoxy)-acetic acid | 12.5 mg | † |
| ((2s)3-(4-cyanophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) | 20 mg | † |
Other ingredients: Magnesium Stearate, Rice Flour, Talc.
Label source: NIH label database · Report a label change
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Graded November 14, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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