Member's Mark Probiotic + Prebiotic Gummies Review
Product Focus: Healthy AgingAlso covers:DigestionImmune systemMuscles and jointsRanked among:Probiotics
Tier ⓘ
Tier 3 · Rank 23
Tier 3 · Reviewed. Strong review agreement, with limited or early support from human studies. Rank 23 within Tier 3 for Healthy Aging; 131 of 215 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
51 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
85% of 233
Biohacker Mentions
0 of 10
We don’t sell supplements. We help you make decisions and get the best price.
Lowest prices
We may earn a commission from some store links. How we choose.
We hold no current store prices for it yet: check the store.
- AmazonPrice at AmazonCheck price at Amazon (opens in a new tab)
Some links earn us a commission; price comes first, and a commission only decides the order of prices within 2%. As an Amazon Associate we earn from qualifying purchases.
Study, Trial or Testing Result Summary
Members Only48 human studies · 38 improved
48 human studies38 improved3 no effect3,858 people studied
This gummy lists only a probiotic and prebiotic blend, and the label does not say which strains or how much of each it contains, so we cannot tell whether it matches the doses used in studies. Specific probiotic strains and prebiotic fibres have been tested in older adults with mostly good results. A six-month trial in adults aged 60 and older found a daily probiotic slowed the shortening of telomeres, the protective caps on chromosomes [1]. In adults averaging about 85 years old, two probiotic strains for 30 days raised young-type immune cells compared with placebo [2]. Three months of an inulin and oligofructose fibre blend improved frailty, walking speed and grip strength in frail older adults [3]. Twelve weeks of one probiotic strain improved leg strength and lowered inflammation in adults aged 65 to 85 [4]. Multistrain capsules taken for 16 weeks improved grip strength, walking speed and inflammation in older adults with joint or lung disease [5][6]. One of these trials did not significantly slow muscle loss [6]. None of these studies tested this gummy, and the strains in it are unknown. Animal and cell studies are never counted.
See all 48 studies →Hide the studies
- Across 61 pooled studies of diet and skin ageing, prebiotics and probiotics improved skin hydration compared with controls.Dietary interventions in skin ageing: a systematic review and meta-analysis.
- A review of 26 animal and 10 human studies found probiotics and prebiotics helped muscle in animals, but six human trials showed inconsistent effects on muscle mass, function and gut bacteria.Understanding the gut microbiota and sarcopenia: a systematic review.
- A review of four randomized trials in men with idiopathic infertility found probiotics reduced oxidative stress, protected sperm DNA and improved sperm parameters, especially motility.Probiotics supplementation in the treatment of male infertility: A Systematic Review.
- In two placebo-controlled trials of 136 and 104 middle-aged adults, probiotic yoghurt for four weeks lowered LDL cholesterol in people with normal weight and lowered blood glucose and oxidative stress in overweight people.Impact of Lactiplantibacillus plantarum Inducia on metabolic and antioxidative response in cholesterol and BMI variable …
- In 200 prefrail and frail older adults, three months of an inulin and oligofructose blend improved frailty, kidney function, walking speed and grip strength compared with placebo.Prebiotics improve frailty status in community-dwelling older individuals in a double-blind, randomized, controlled tria…
- In 169 middle-aged and older adults, three months of Lactobacillus rhamnosus GG shifted gut bacteria in those with mild cognitive impairment, and the shifts matched improved cognitive scores.The gut microbiome, mild cognitive impairment, and probiotics: A randomized clinical trial in middle-aged and older adul…
- In 119 adults aged 65-85, twelve weeks of live or heat-treated PS23 improved lower limb strength and endurance and lowered C-reactive protein and interleukin-6 compared with placebo, without changing muscle mass.Enhancement of Lower Limb Muscle Strength and Reduction of Inflammation in the Elderly: A Randomized, Double-Blind Clini…
- In 115 adults aged 60-75 with knee osteoarthritis, one daily multistrain probiotic capsule for 16 weeks lowered gut permeability and inflammation and improved pain, walking speed, grip strength and physical performance.Probiotics improve functional performance in patients with osteoarthritis: a randomized placebo-controlled clinical tria…
- In 105 men with Alzheimer's disease, four months of a daily probiotic improved grip strength, walking speed and physical performance and lowered gut leakage, inflammation and oxidative stress compared with placebo.Probiotics combat sarcopenia by restoring gut integrity in Alzheimer's disease.
- In 100 men aged 63-73 with chronic lung disease, one multistrain probiotic capsule a day (112 billion organisms) for 16 weeks improved handgrip strength, walking speed and physical performance scores and lowered blood markers of inflammation and oxidative stress compared with placebo, though it did not significantly reduce the rate of muscle loss (sarcopenia).A multistrain probiotic improves handgrip strength and functional capacity in patients with COPD: A randomized controlle…
- In 98 adults averaging about 85 years old, a biscuit with two probiotic strains for 30 days increased naive, regulatory and activated memory T cells, B cells and natural killer cell activity compared with placebo, while routine blood chemistry did not change.Supplementation with Bifidobacterium longum Bar33 and Lactobacillus helveticus Bar13 mixture improves immunity in elderl…
- In 97 healthy older adults, six months of a daily probiotic blend changed a blood inflammation marker significantly more than placebo and raised gut beneficial bacteria and short-chain fatty acids.Impact of a probiotic diet on well-being of healthy senior: THE PROBIOSENIOR PROJECT.
- In 90 people with mild to moderate Alzheimer's disease, 12 weeks of a single-strain probiotic twice daily improved blood markers of oxidative stress and inflammation compared with placebo.The effects of probiotic supplements on oxidative stress and inflammation in subjects with mild and moderate Alzheimer's…
- In 89 healthy older adults, six weeks of 2'-fucosyllactose missed its main immune-response goal but raised gut Bifidobacterium, insulin, HDL cholesterol and FGF21, and responders did better on a visual memory test.A human milk oligosaccharide alters the microbiome, circulating hormones, and metabolites in a randomized controlled tri…
- In 74 smokers taking a multi-strain probiotic (1.8 billion CFU daily) for 12 weeks, fasting glucose, triglycerides, and C-reactive protein fell compared with placebo, but anxiety, depression, and nicotine dependence did not change.The effect of probiotics on anxiety, depression, nicotine dependence, and metabolic biomarkers in smokers: a randomized …
- In 70 patients on methadone maintenance, 1.8 billion CFU of probiotics daily for 12 weeks, compared with placebo, improved depression severity, lowered blood sugar and cholesterol, reduced high-sensitivity C-reactive protein, and raised total antioxidant capacity and glutathione.Read the study on PubMed (35685534) →
- In 70 adults with knee osteoarthritis who were overweight or obese, taking Saccharomyces boulardii probiotic for 12 weeks reduced pain more than placebo and lowered inflammatory marker hs-CRP and oxidative stress marker MDA.Saccharomyces boulardii improves clinical and paraclinical indices in overweight/obese knee osteoarthritis patients: a r…
- In 67 overweight elderly men taking one 240 mL bottle of probiotic-fortified kefir daily for 8 weeks, depression scores improved more than with regular kefir, and total antioxidant capacity rose, but appetite, inflammation, and other oxidative markers did not differ.The effect of probiotic-fortified kefir on depression, appetite, oxidative stress, and inflammatory parameters in Irania…
- In 66 people with Parkinson's disease taking a synbiotic with standard L-dopa for 3 months, motor and non-motor symptoms improved more than with L-dopa alone, along with lower TNF-alpha and MDA and higher BDNF.Randomized controlled trial evaluating synbiotic supplementation as an adjuvant therapy in the treatment of Parkinson's …
- In 64 pregnant women with gestational diabetes, an 8-week four-strain probiotic capsule improved inflammation markers (high-sensitivity C-reactive protein and TNF-alpha) and oxidative stress markers (malondialdehyde and glutathione enzymes) compared with placebo.Effect of probiotic supplements in women with gestational diabetes mellitus on inflammation and oxidative stress biomark…
- In 60 people on dialysis with diabetes, 12 weeks of a three-strain probiotic capsule improved blood sugar control and lowered inflammation and oxidative stress markers compared with placebo.Probiotic supplementation in diabetic hemodialysis patients has beneficial metabolic effects.
- In 60 women with gestational diabetes, a synbiotic capsule taken for 6 weeks lowered an inflammation marker and a lipid oxidation marker and raised antioxidant capacity compared with placebo.The Effects of Synbiotic Supplementation on Pregnancy Outcomes in Gestational Diabetes.
- In 60 women with polycystic ovary syndrome, a 12-week probiotic supplement lowered high-sensitivity C-reactive protein and malondialdehyde and raised total antioxidant capacity compared with placebo, along with improvements in hormone levels.Effects of Probiotic Supplementation on Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women With…
- In 60 adults with diabetic kidney disease, 8 billion CFU of probiotics daily for 12 weeks, compared with placebo, lowered a marker of cell-damaging fat breakdown (malondialdehyde) and an inflammation marker (high-sensitivity C-reactive protein) and raised total glutathione, an antioxidant.Metabolic and genetic response to probiotics supplementation in patients with diabetic nephropathy: a randomized, double…
- In a placebo-controlled trial of 60 healthy older adults, taking one sachet daily of Bifidobacterium longum BB68S for 8 weeks improved memory, attention and visual-spatial thinking scores compared with placebo.Probiotic Bifidobacterium longum BB68S Improves Cognitive Functions in Healthy Older Adults: A Randomized, Double-Blind,…
- In a placebo-controlled trial of 60 adults with type 2 diabetes, 2.8 grams a day of an anthocyanin and fibre supplement for 60 days improved blood sugar and cholesterol, but markers of oxidative stress, inflammation and fitness did not change compared with the control group.Diabetes Therapeutics of Prebiotic Soluble Dietary Fibre and Antioxidant Anthocyanin Supplement in Patients with Type 2 …
- In 57 adults with age-related macular degeneration taking a probiotic capsule for 8 weeks, antioxidant capacity and HDL cholesterol rose and MDA fell compared with placebo, but clinical eye signs and other metabolic markers did not change.Therapeutic effect of probiotics on metabolic indices and clinical signs in age-related macular degeneration.
- In 55 adults with relapsing multiple sclerosis, a probiotic taken twice daily for four months did not change antioxidant or oxidative stress markers more than placebo.The effects of probiotics supplementation on serum markers of oxidative stress in relapsing-remitting multiple sclerosis…
- In 52 infertile men, 500 mg of probiotics daily for 10 weeks, compared with placebo, raised sperm concentration and motility and lowered oxidative stress and inflammation markers; this paper has been retracted.Probiotic effects on sperm parameters, oxidative stress index, inflammatory factors and sex hormones in infertile men.
- In 50 adults with high cholesterol, Lactobacillus paracasei taken daily for 90 days lowered an oxidative stress marker and an inflammation marker compared with placebo.Safety and Effects of Lactobacillus paracasei TISTR 2593 Supplementation on Improving Cholesterol Metabolism and Atheros…
- In 46 patients with psoriasis taking a multi-strain probiotic (at least 1.6 billion CFU per gram) for 2 months, quality of life and skin severity improved more than with placebo, and CRP and IL-1 beta fell.Probiotics Supplementation Improves Quality of Life, Clinical Symptoms, and Inflammatory Status in Patients With Psorias…
- In 46 women with obesity, taking L-carnitine with a multi-strain probiotic and prebiotic blend for 8 weeks lowered inflammation markers and oxidative stress, while L-carnitine alone did not significantly change them.L-Carnitine and synbiotic co-supplementation: beneficial effects on metabolic-endotoxemia, meta-inflammation, and oxidat…
- In 46 adults aged 60 and older taking a probiotic (5 billion CFU daily) for 6 months, leukocyte telomere shortening slowed compared with placebo.Probiotic Supplementation in Aged Human Subjects Counteracts Leukocyte Telomere Attrition Rate.
- In 44 adults with metabolic syndrome, eating 300 g per day of synbiotic yogurt for 12 weeks improved oxidative stress measures, including glutathione peroxidase and total oxidant status, compared with regular yogurt.Consumption of a new developed synbiotic yogurt improves oxidative stress status in adults with metabolic syndrome: a ra…
- In 43 healthy men aged 50 to 72, an eight-week diet, sleep, exercise and supplement program with probiotics lowered their DNA methylation biological age by about 3.23 years compared with a control group that received no intervention.Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial.
- In 42 people with rheumatoid arthritis, a daily five-strain probiotic sachet for 60 days lowered certain inflammatory markers and improved several antioxidant measures compared with placebo, though other inflammatory markers and disease activity did not change.Mixture of probiotics reduces inflammatory biomarkers and improves the oxidative/nitrosative profile in people with rheu…
- In a placebo-controlled trial of 40 adults with depression, eight weeks of a three-strain probiotic capsule lowered C-reactive protein, a marker of inflammation, compared with placebo.Clinical and metabolic response to probiotic administration in patients with major depressive disorder: A randomized, do…
- In 40 adults with inflammatory bowel disease taking a probiotic for 90 days, oxidant levels (d-ROMs) improved compared with placebo and antioxidant capacity (BAP) rose.Probiotics Efficacy on Oxidative Stress Values in Inflammatory Bowel Disease: A Randomized Double-Blinded Placebo-Contro…
- In 40 adults with multiple sclerosis, Saccharomyces boulardii taken for four months lowered an inflammation marker and raised antioxidant capacity compared with placebo.The effect of probiotic supplementation on the clinical and para-clinical findings of multiple sclerosis: a randomized c…
- In 40 adults with mild Alzheimer's disease, a daily E. coli Nissle 1917 probiotic capsule for 6 weeks lowered inflammation and oxidative stress markers and endotoxin, and improved memory test scores compared with placebo, though the authors say larger studies are needed.Effect of the probiotic Escherichia coli Nissle 1917 on serum levels of NADPH oxidase-2 and lipopolysaccharide in patien…
- In 40 older men with type 2 diabetes who did resistance training, adding a synbiotic to protein gave no extra benefit for strength, inflammation or oxidative stress beyond protein and training alone.Synergistic effects of synbiotic, protein supplementation, and resistance training on inflammation, oxidative stress, an…
- In 37 adults with chronic kidney disease, a 6-week synbiotic crossover trial significantly lowered one uremic toxin (p-cresyl sulfate) but not indoxyl sulfate, and other secondary outcomes, including oxidative stress and inflammation markers, did not change except for a rise in albuminuria.Synbiotics Easing Renal Failure by Improving Gut Microbiology (SYNERGY): A Randomized Trial.
- In a placebo-controlled metabolomics study of adults with major depression, adding Lactobacillus plantarum 299v to a med treatment lowered long-chain acylcarnitines, which may point to better mitochondrial function; this was an exploratory study and the abstract does not report the number of participants.Probiotic Lactobacillus plantarum 299v supplementation in patients with major depression in a double-blind, randomized, …
- A topical serum containing 30% tetrahexyldecyl ascorbate, a patent-pending antioxidant and prebiotic blend, visibly corrected photodamage and hyperpigmentation in a clinical trial and reduced reactive oxygen species in lab models, with no adverse events reported.Hydroquinone-Free, Tetrahexyldecyl Ascorbate Antioxidant Serum for Hyperpigmented and Photodamaged Skin to Achieve Skin …
- In 21 adults, a probiotic ointment applied twice daily for 56 days improved skin hydration, firmness, elasticity and wrinkles, with no control group.Topical Lactiplantibacillus plantarum LB244R® ointment alleviates skin aging: An exploratory trial.
- In Alzheimer's patients taking 2 mL per kg of body weight of kefir daily for 90 days in an uncontrolled study, memory and thinking tests improved, along with lower inflammation and oxidative stress markers.Oxidative Stress and Dementia in Alzheimer's Patients: Effects of Synbiotic Supplementation.
- In a case series of six women, an 8-week diet, sleep, exercise and probiotic program lowered DNA-measured biological age by an average of 4.6 years, with five of six women showing a reduction.Potential reversal of biological age in women following an 8-week methylation-supportive diet and lifestyle program: a c…
- In elderly people eating a prebiotic-enriched formulated food for 8 weeks in a randomized self-controlled trial, age-related physiological decline was reduced and beneficial gut bacteria increased, though response varied between individuals.Novel formulated food for the elderly regulates specific gut bacterial taxa and improves host physiology.
Review Totals and Summary
Members Only233 reviews · 85% positive
233 reviews · Google Shopping 233
85% positive0% neutral15% negative
Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.
Biohacker Summary
Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it
Three of the ten panelists spoke about the probiotic blend, the main ingredient, and none of them advised against it. One panelist recommends it and says it is the only probiotic he uses, praising its science, its multi-stage delivery and the maker's openness about clinical trials. Another takes and recommends a daily blend of probiotics with prebiotics, citing 24 strains, a capsule-in-capsule design, and less bloating and gas with better regularity, and he once gave a general probiotic blend to a patient for gut health. The third recommended a daily probiotic and prebiotic pair because gut health affects the whole body, and also uses blends meant to place probiotics in the lower intestine, though his latest comment on the blend was neutral. For pairing, one panelist suggests taking it a couple of hours apart from fermented foods, and says it works well when changing diets or alongside honey to shift the gut microbiome quickly; no doses or cautions were given, and no one said they stopped.
See all 3 biohackers →Hide the biohackers
Thomas DeLauer · Probiotic Blend · recommends
- Recommends Seed probiotic, stating it's the only probiotic he would ever recommend due to its scientific approach and multi-stage delivery system.
- Highly recommends Seed Daily Synbiotic, a prebiotic and probiotic, to capitalize on the beneficial effects of fermented foods and improve gut health, suggesting it be taken a couple of hours apart from fermented foods.
- Recommends Seed Daily Synbiotic, a prebiotic and probiotic in one, especially when changing diet or acclimating to a new diet style, and offers a discount code.
- Recommends Seed's daily symbiotic, which is a prebiotic and probiotic in one capsule, as a great tool to use in conjunction with honey to shift and alter the microbiome rapidly.
- Is a huge fan of Seed Daily Symbiotic and states it's the only probiotic he personally uses, appreciating their transparency in publishing clinical trials, even when results aren't in their favor.
- Recommends Seed's daily symbiotic, which contains a prebiotic and probiotic in one capsule, for good digestive health and notes the brand's commitment to microbiome research.
- Recommends Seed Daily Synbiotic, stating it's the only probiotic he would ever recommend, especially when in a caloric deficit or changing one's diet, due to its unique capsule-in-capsule technology for better colonization of bacteria in the gut.
- Recommends Seed's daily symbiotic, which contains a prebiotic and probiotic in one capsule, for those looking to improve their gut microbiome, noting its unique technology and the company's funding of microbiome research.
- Recommends Seed, a synbiotic that combines a probiotic and prebiotic, for people who are intermittent fasting and may not be getting a wide variety of food, to help support their gut biome.
- Likes that Ample includes a probiotic blend, specifically mentioning L-rhamnosus as a highly researched strain.
Dr. Mark Hyman · Probiotic Blend · uses
- Continues to recommend and take Seed's DS-01 Daily Synbiotic, highlighting its 24 unique probiotic strains, capsule-in-capsule technology, and clinical evidence for reducing bloating, alleviating gas, and improving regularity.
- Gave a good general probiotic blend to a patient to improve gut health.
Ben Greenfield · Probiotic Blend · neutral
- Notes that IM8health includes a full probiotic blend for the gut.
- Recommends Seed's Daily Synbiotic for those who want to add a probiotic + prebiotic to their daily routine, noting that gut health affects whole-body health.
- Uses probiotic blends APO-808™ and APO-19™ as part of Dr. John Lieurance's Travel Hacking Kit, which are designed to assist in gut health by placing probiotics in the lower intestine.
RAL Summary
Members OnlyTier 3 for Healthy Aging
Tier 3 rests on 233 reviews with 85% positive; the study support is for specific strains and fibres in older adults, while this product hides its strains and amounts in a blend, so it cannot rank higher [1][3].
- Probiotic and Prebiotic Blend: amount hidden in a blend
Where the evidence disagrees: 3 of the 48 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Digestive system, Immune system, Musculoskeletal system
Combine with: Combine with a healthy diet and lifestyle.
Possible side effects: No major side effects reported.
Supplement Facts
Total Carbohydrates 4 g · Proprietary Probiotic Blend 0 · Xylo-oligosaccharides 80 mg
Supplement Facts
Serving Size 2 Gummie(s)
Servings Per Container 75
Amount Per Serving% Daily Value
| Calories | 17 | |
| Total Carbohydrates | 4 g | |
| Proprietary Probiotic Blend | 0 | † |
| Xylo-oligosaccharides | 80 mg | † |
† Daily Value not established.
Other ingredients: Apple Juice Concentrate, Apple puree concentrate, Strawberry puree, Raspberry puree, Blackberry puree, Mango puree concentrate, organic Peach puree, Black Currant juice concentrate, Blackberry juice concentrate, Pectin, Natural flavor, Lemon juice concentrate, Potassium Citrate, Ascorbic Acid, Purple Carrot Juice Concentrate, Microcrystalline Cellulose, Vegetable Oil, Beeswax, Carnauba Wax.
Directions: Suggested Use: Adults and children 3 years and older, chew two (2) gummies per day. Chew thoroughly before swallowing.
Barcode (UPC) 078742256566 · Label source: NIH label database · Report a label change
Show entire label
More healthy aging products
Members OnlyThe highest ranked for the same goal
Read more
Our articles on this subject
- Healthy Aging Tips: A Science-Backed Guide to Living Better for LongerArticle · Mar 17, 2026
- NAD Anti-Aging Supplements: Benefits, Evidence, and How to ChooseArticle · Jun 15, 2026
Graded November 14, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
Privacy policyConsumer health dataAffiliate disclosureTermsDo Not Sell or Share My Personal InformationCookie settings