Monster Energy Absolutely Zero Review

Monster Energy Absolutely Zero is a carbonated, sugar-free and calorie-free energy drink sold in 16 fl oz cans. Monster introduced it as a reworked successor to its Lo-Carb line. Its stated aim is a zero-sugar drink that still tastes like a regular Monster. The flavor is a fruity, berry-leaning profile. The label calls it a re-tooled energy blend with a new sweetener system. Each can contains about 140 mg of caffeine. Monster first quoted 135 mg and later adjusted the figure to 140 mg. The base is carbonated water and citric acid. Erythritol, sucralose and acesulfame potassium (ace-K) provide sweetness. Sodium citrate buffers the acidity. Sorbic and benzoic acid are the preservatives. The Amazon listing names taurine, caffeine and ginseng as the special ingredients. The energy blend, about 2,800 mg, includes taurine, Panax ginseng extract, L-carnitine L-tartrate, glucuronolactone, inositol, guarana and maltodextrin. It also contains B vitamins such as niacinamide. The effects come from several mechanisms: - **Caffeine** is the main active ingredient. It blocks adenosine receptors in the brain, which reduces the sensation of tiredness. It raises alertness and focus, and it usually takes effect within 10 to 45 minutes of drinking. - **Guarana** supplies additional caffeine-like stimulant compounds. - **B vitamins** such as niacin (B3) take part in normal energy-yielding metabolism. They don't act as stimulants. They support the conversion of food into usable energy and help reduce fatigue. - **Taurine, L-carnitine and ginseng** are included for their roles in nutrient metabolism and perceived vitality. Their effects at these doses are modest, and the caffeine does most of the work. - **The sweetener system** removes the sugar, so there is no glucose spike followed by a crash. Erythritol is a sugar alcohol that adds bulk and sweetness with essentially no calories. Sucralose and ace-K add sweetness without being metabolized for energy. The drink suits people who want a Monster-style lift without sugar or calories. Caffeine sensitivity varies. Pregnant women, children, and people with heart conditions or caffeine sensitivity should avoid or limit it. It should not be combined with other caffeine sources. Total daily caffeine for healthy adults is generally advised to stay under about 400 mg.

Product Focus: EnergyAlso covers:BrainDigestion
Tier ⓘ
Tier 4 · Rank 28
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 28 within Tier 4 for Energy; 71 of 86 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
35 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
– no stars shown, 398 reviews
Biohacker Mentions
10 of 10

Study, Trial or Testing Result Summary

Members OnlyHuman studies

We could not find any ingredient study findings for this product and this goal, so there is no study-based summary to give yet. The label amounts per can are unknown. The store listing says the drink has about twenty ingredients, including three sweeteners, two preservatives, caffeine and a second caffeine source, plus natural flavours, but it does not name or measure them one by one. Because no ingredient is named with a dose, we cannot say whether any ingredient reaches the amount used in research or whether some are hidden inside a flavour or energy blend. No human studies on energy were given for this product's ingredients, so any energy effect is not confirmed by the research we reviewed. The little customer feedback we found was mostly positive about taste and a smooth, crash-free lift, but it came from only a handful of sources and no reviews were counted. Members should treat this product as unproven for energy until the full label and matching studies can be checked. Animal and cell studies are never counted.

Review Totals and Summary

Members Only398 reviews
398 reviews · Google 398

The feedback I could find is mostly positive, centered on flavor and the quality of the energy. Customers repeatedly say the berry-like taste is a clear step up from many other zero-sugar energy drinks. In an Amazon Q&A thread, one buyer preferred it to Monster Ultra, which they found too citrusy. That buyer also valued the lack of a lingering aftertaste, which is a common complaint about diet-style energy drinks. Reviewers describe the can as smooth and easy to drink cold. Some say they would not have guessed it was sugar-free. The energy effect gets similar praise. A professional reviewer at Caffeine Informer noticed a boost within about ten minutes, in line with other Monster products. That reviewer described it as less jittery than higher-sugar Monsters. They also described a slow fade-out with no crash. People who want sustained focus for work or driving like the mild, steady effect. Some customers like that it gives a typical Monster kick at 140 mg without calories, which suits dieting, low-carb and keto lifestyles. Criticisms are less detailed in what I read, but they fit the usual pattern for this kind of drink. Sugar-alcohol and artificial-sweetener blends such as erythritol, sucralose and ace-K can leave a faint sweetener note for sensitive tasters. Some people can also have digestive discomfort from sugar alcohols. Caffeine-sensitive customers may find 140 mg too strong for later in the day. Others say the effect is mild if they are used to stronger drinks. Availability and price come up as well, since multipacks can be expensive. Some fans also worry that flavors get discontinued or reformulated. Overall, customers value the flavor and the clean, crash-free energy, and the main reservations are sweetener sensitivity and caffeine tolerance. This summary rests on only a handful of sources, so it is not a statistically broad picture.

Biohacker Summary

Members Only10 of 10 recommend it
10 of 10 biohackers on our panel recommend it

The product has no main ingredient on the panel's record, so everything here concerns smaller ingredients, chiefly vitamin B12 and vitamin B6. For vitamin B12, most of the panel recommends it or uses it, mainly for nerve health, brain function, mood and energy, and several say to get tested and supplement only if low, with extra attention for vegans and vegetarians. The form most often preferred is methylcobalamin, with one panelist favoring a liposomal or micellar version and another a sublingual form for older people, and one panelist aims for a blood level around 500. Vitamin B6 draws more caution: three panelists warn against the synthetic pyridoxine form or against over-supplementing because of nerve damage, while others favor the active P5P form or pair B6 with magnesium, folate and B12. One panelist also warns against taking B12 too close to bedtime because it works against melatonin.

See all 10 biohackers →Hide the biohackers
  • Thomas DeLauer · Vitamin B12 · recommends
    • 18 Oct 2026 · recommends · YouTube ↗
      Recommends Vitamin B12 for mental health and mood, explaining its role in myelination and neurotransmitter production. They specifically recommend a liposomal and micellar form of methylcobalamin B12 for better absorption and to avoid toxicity.
    • 5 Aug 2026 · Vitamin B2 · warns · Instagram ↗
      Warns against conventional cereal, describing it as extruded, sugared, and then sprayed with vitamins that were destroyed during its making.
    • 30 Jun 2026 · neutral · YouTube ↗
      Mentions that a single serving of sardines provides vitamin B12 at something like three to four times the daily needs.
    • 29 Jun 2026 · recommends · YouTube ↗
      Recommends taking methylcobalamin as a methylated form of B vitamin for mitochondrial function.
    • 20 May 2026 · Vitamin B6 · recommends · YouTube ↗
      Recommends ensuring adequate vitamin B6 intake, as it is a required cofactor for cells to use absorbed magnesium and improves central nervous system relaxation when combined with magnesium.
    • 7 May 2026 · Vitamin B6 · recommends · YouTube ↗
      Recommends vitamin B6 to support GABA production and find balance for mental clarity.
    • 25 Feb 2026 · Vitamin B2 · neutral · YouTube ↗
      Mentions riboflavin as a critical B vitamin for reducing homocysteine.
    • 25 Feb 2026 · Vitamin B6 · neutral · YouTube ↗
      Mentions B12 as a critical B vitamin for reducing homocysteine.
    • 11 Dec 2025 · warns · YouTube ↗
      Advises against taking vitamin B12 if one's diet already provides enough, suggesting a B complex or liver capsule instead for B vitamins.
    • 30 Oct 2025 · stopped · YouTube ↗
      Was taking Vitamin B12 with fat burner injections, which he later stopped cold turkey, leading to a period of intense emotional and hormonal imbalance.
    • 17 Oct 2025 · warns · YouTube ↗
      Warns that high levels of supplemental vitamin B12 are a risk factor for insomnia, as it is an energy-building supplement, and advises taking it in the morning or lowering the dose.
    • 23 Aug 2025 · Vitamin B2 · neutral · YouTube ↗
      Notes that Vitamin B2 acts as an electron carrier, assisting in redox reactions and the electron transport chain to produce energy.
    • 17 Apr 2025 · recommends · YouTube ↗
      Notes that depending on one's diet, adding a good multivitamin might be beneficial, specifically recommending a methylated multivitamin for better absorption and utilization.
    • 17 Apr 2025 · Vitamin B6 · recommends · YouTube ↗
      Notes that depending on one's diet, adding a good multivitamin might be beneficial, specifically recommending a methylated multivitamin for better absorption and utilization.
  • Dr. Eric Berg · Vitamin B6 · warns
    • 10 Oct 2026 · warns · Podcast ↗
      Dr. Berg lists pyridoxine hydrochloride as a synthetic vitamin to avoid.
    • 4 Oct 2026 · recommends · Facebook ↗
      Recommends taking the active form of vitamin B6, pyridoxal-5-phosphate (P5P), for its benefits to the nervous system, including building the myelin sheath and protecting sensory nerve integrity.
    • 4 Oct 2026 · neutral · X ↗
      Notes that Vitamin B6 is intimately involved in the nervous system and may be behind sciatica and carpal tunnel syndrome.
    • 4 Oct 2026 · Vitamin B12 · recommends · Facebook ↗
      Recommends taking the natural form of vitamin B12, methylcobalamin, to support nerve regeneration, myelin production, and nerve growth factors.
    • 4 Oct 2026 · Vitamin B12 · neutral · X ↗
      Notes that Vitamin B12 is intimately involved in the nervous system and may be behind sciatica and carpal tunnel syndrome.
    • 20 Sep 2026 · Vitamin B12 · recommends · Facebook ↗
      Recommends taking vitamin B12 if on a med.
    • 15 Sep 2026 · neutral · Podcast ↗
      States that high vitamin B6 levels can be linked to peripheral neuropathy.
    • 15 Sep 2026 · Vitamin B12 · neutral · Podcast ↗
      Briefly mentions Vitamin B12 in relation to neuropathy.
    • 10 Sep 2026 · Vitamin B12 · neutral · Instagram ↗
      States that vertical ridges on nails could mean a vitamin B12 deficiency, and slightly brown or grey nails, especially for vegans, could indicate low B12. Completely white nails with a pink strip across the top could also be low B12.
    • 8 Sep 2026 · Vitamin B12 · recommends · Instagram ↗
      Recommends incorporating vitamin B12 foods into the diet, especially for those who don't regularly consume animal products, to prevent irreversible damage to the nervous system.
    • 3 Sep 2026 · Vitamin B12 · neutral · Facebook ↗
      Dr. Berg mentions that fermented dairy contains vital nutrients, including vitamin B12.
    • 3 Sep 2026 · Vitamin B2 · neutral · Facebook ↗
      Dr. Berg mentions that fermented dairy contains vital nutrients, including vitamin B2.
    • 1 Sep 2026 · Vitamin B12 · neutral · Facebook ↗
      A vitamin B12 deficiency can cause irreversible damage to your nervous system, so it's important to prioritize acidifying your stomach as you age.
    • 25 Aug 2026 · Vitamin B12 · neutral · Facebook ↗
      States that Vitamin B12 is crucial for health and many people are deficient without realizing it.
  • Dr. Mark Hyman · Vitamin B6 · uses
    • 31 Aug 2026 · uses · YouTube ↗
      Optimized a child's nutrient status with vitamin B6, as the child had low B6 levels.
    • 22 Jul 2026 · Vitamin B12 · recommends · YouTube ↗
      States that vitamin B12 is a nutritional deficiency that impacts mental health.
    • 29 Jun 2026 · recommends · Facebook ↗
      Recommends vitamin B6 with folate and B12 as supplements with strong evidence for PMS.
    • 29 Jun 2026 · Vitamin B12 · recommends · Facebook ↗
      Recommends vitamin B12 with vitamin B6 and folate as supplements with strong evidence for PMS.
    • 3 Jun 2026 · neutral · YouTube ↗
      Believes that if functional testing is done to replete deficiencies like vitamin D and B12 before someone stops their medication, withdrawal symptoms can be completely eliminated.
    • 3 Jun 2026 · Vitamin B12 · recommends · YouTube ↗
      Mentions that repletion of vitamin B12 can help safely withdraw someone from meds and that simple vitamin B12 deficiencies are important to address in a depression workup.
    • 18 Apr 2026 · Vitamin B12 · neutral · Facebook ↗
      Lists Vitamin B12 as important for nerve health and energy.
    • 8 Oct 2025 · Vitamin B2 · neutral · YouTube ↗
      Lists riboflavin as a B vitamin cofactor that helps mitochondrial function.
    • 12 Mar 2025 · Vitamin B12 · neutral · YouTube ↗
      Mentions vitamin B12 as a core nutrient required for methylation, noting that deficiencies can lead to various health issues.
    • 6 Dec 2024 · Vitamin B12 · recommends · YouTube ↗
      Recommends supplementing with Vitamin B12 for hair follicle health and growth, especially for vegans, as many people are deficient.
    • 4 Dec 2024 · Vitamin B12 · recommends · YouTube ↗
      Recommends checking vitamin B12 levels as a first step before taking any supplements.
    • 29 Nov 2024 · Vitamin B12 · warns · YouTube ↗
      Warns that meds (meds) block the absorption of vitamin B12, which requires stomach acid to be absorbed. Long-term B12 deficiency can lead to depression, neurological problems, and dementia.
    • 15 Nov 2024 · recommends · YouTube ↗
      States that Vitamin B6, at 50 to 100, is important for estrogen metabolism.
    • 15 Nov 2024 · Vitamin B12 · recommends · YouTube ↗
      Recommends Vitamin B12 in the form of methylcobalamin, about 1000 micrograms a day, as a methylating vitamin necessary for detoxifying and excreting hormones.
  • Ben Greenfield · Vitamin B12 · recommends
    • 9 Jul 2026 · recommends · YouTube ↗
      Recommends getting vitamin B12 tested and supplementing if deficient, as B12 deficiency can cause damage to the myelin coating around nerves, including cochlear nerves, and improve tinnitus severity scores.
    • 19 Jul 2025 · Vitamin B6 · recommends · YouTube ↗
      Recommends Vitamin B6 for the conversion of tryptophan to serotonin and then melatonin in the pineal gland.
    • 26 Dec 2024 · recommends · YouTube ↗
      He recommends Vitamin B12, especially for kids on a vegan or vegetarian diet, as it is essential for nervous system development.
    • 29 Aug 2024 · neutral · YouTube ↗
      Mentions that blood testing for an energy crisis would include nutritional things like a vitamin B12 level.
    • 4 Jul 2024 · uses · YouTube ↗
      Ben Greenfield consumes vitamin B12 as part of the Update Energy Drink.
    • 24 Aug 2023 · neutral · YouTube ↗
      Lists vitamin B12 as a vitamin that, when combined with others, has a neuroprotective effect on the brain.
    • 24 Aug 2023 · Vitamin B6 · neutral · YouTube ↗
      Lists vitamin B6 as a vitamin that, when combined with others, has a neuroprotective effect on the brain.
    • 6 Apr 2023 · Vitamin B6 · uses · YouTube ↗
      Leland ensures adequate Vitamin B6 for patients to optimize endogenous melatonin production.
    • 25 Mar 2023 · neutral · YouTube ↗
      Ben notes that vitamin B12 is in the drink, and Shawn specifies it's the methylated coenzymated form, methylcobalamin.
    • 1 Dec 2022 · Vitamin B6 · recommends · YouTube ↗
      Ben recommends HIYA Kids Multivitamin as a pediatrician-approved, superpowered chewable multi that is zero sugar, non-GMO, vegan, dairy-free, allergy-free, gelatin-free, and nut-free, formulated with 12 organic fruits and veggies and 15 essential vitamins and minerals.
    • 3 Nov 2022 · neutral · YouTube ↗
      Mentions that Haya multivitamin contains Vitamin B12.
    • 3 Nov 2022 · Vitamin B6 · warns · YouTube ↗
      Warns that most typical children's vitamins are basically candy in disguise, containing two teaspoons of sugar, unhealthy chemicals, and gummy junk that growing kids should never eat.
    • 30 Nov 2021 · Vitamin B2 · uses · YouTube ↗
      Uses a Fast Vitamin IV from Conover Wellness to address immune system issues, self-administering it when feeling down or after long flights.
    • 13 Mar 2021 · Vitamin B6 · recommends · Podcast ↗
      Ben mentions that tryptophan and vitamin B6 are necessary to produce melatonin.
  • Dave Asprey · Vitamin B12 · recommends
    • 1 Jul 2026 · recommends · YouTube ↗
      States that Vitamin B12 is extremely important for every kind of brain function and recommends ensuring B12 levels are optimal, around 500, not just barely above normal.
    • 1 Jan 2026 · Vitamin B6 · neutral · YouTube ↗
      Mentions Vitamin B6 as playing a role in methylation pathways.
    • 9 Oct 2025 · recommends · YouTube ↗
      Recommends taking vitamin B12 if one has a deficiency.
    • 21 Dec 2024 · Vitamin B6 · warns · YouTube ↗
      Warns that the synthetic form of vitamin B6 found in almost all multivitamins and energy drinks binds to B6 receptors for a thousand days, making them unavailable for the beneficial form.
    • 1 Feb 2024 · neutral · YouTube ↗
      Dave Asprey notes that it's almost impossible to get vitamin B12 in a vegan diet, and it's primarily found in animal meat.
    • 25 Jan 2024 · Vitamin B6 · uses · YouTube ↗
      Says they would take a bunch of their Wild Lights Vitamin B6 if they had to eat almonds, to try and pass them.
    • 12 Dec 2023 · Vitamin B6 · warns · Podcast ↗
      Warns about formulating with Vitamin B6.
    • 10 Nov 2022 · Vitamin B6 · recommends · YouTube ↗
      Identifies P5P, a bioactive form of vitamin B6, as a great cofactor for melatonin production, helping the body naturally produce the hormone.
    • 21 Jul 2021 · neutral · YouTube ↗
      Clarifies that Vitamin B12 is completely different from Vitamin B3 and is involved in different pathways, so there is no overlap with NAD pathways.
    • 8 Dec 2019 · Vitamin B6 · recommends · YouTube ↗
      Recommends feeding the tryptophan pathway with vitamin B6, as it is depleted by birth control and its depletion can lead to depression.
    • 8 Dec 2019 · Vitamin B6 · neutral · YouTube ↗
      Mentions P5P in the context of epigenetic alterations, comparing it to vitamin B6.
    • Date not recorded · recommends · Website ↗
      If one has a MTHFR mutation and cannot process folic acid, Dave Asprey recommends taking vitamin B12 along with methylated folic acid to lower homocysteine levels.
    • Date not recorded · Vitamin B6 · recommends · Website ↗
      Recommends supplementing with Vitamin B6 if homocysteine levels are high, indicating a methylation issue or B12/folate deficiency.
    • Date not recorded · Vitamin B2 · recommends · Website ↗
      Recommends supplementing with Vitamin B2 if homocysteine levels are high, indicating a methylation issue or B12/folate deficiency.
  • Siim Land · Vitamin B12 · uses
    • 24 Apr 2026 · uses · YouTube ↗
      Created Microvitamin, a supplement that bundled all the supplements he was taking, to help fund his a med trial.
    • 24 Mar 2026 · recommends · YouTube ↗
      States that vitamin B12 deficiency is the most common reason for premature graying of hair and recommends fixing B12 status if it is deficient, as it gives a greater likelihood of reversing gray hair.
    • 29 Nov 2024 · Vitamin B6 · neutral · YouTube ↗
      Mentions that insufficient vitamin B6 can raise prolactin levels.
    • 28 Sep 2024 · Vitamin B6 · recommends · YouTube ↗
      Recommends B12 for vegans, noting it is a standard vitamin found in animal products.
    • 13 Aug 2023 · Vitamin B6 · uses · YouTube ↗
      Is experimenting with serine plus vitamin B6 to impact homocysteine levels, a mechanistic hypothesis he is testing.
    • 18 Jun 2023 · uses · Podcast ↗
      Takes 1 gram of Vitamin B12 from DoNotAge in the morning for longevity.
    • 18 Jun 2023 · Vitamin B6 · uses · Podcast ↗
      Takes 1 gram of Vitamin B6 from DoNotAge in the morning for longevity.
    • 18 Jun 2023 · Vitamin B2 · uses · Podcast ↗
      Takes 1 gram of Vitamin B2 from DoNotAge in the morning for longevity.
    • 4 May 2023 · neutral · YouTube ↗
      Mentions Vitamin B12 as a key nutrient involved in the methylation cycle that helps prevent methionine from raising homocysteine levels.
    • 29 Oct 2020 · Vitamin B2 · recommends · YouTube ↗
      States that vitamin B2 is very important for mucous membrane health, which is a first line of defense against infection.
    • 13 May 2019 · neutral · YouTube ↗
      Explains that one can store up to 30 years' worth of vitamin B12 if they get a lot of it, particularly from superfoods like clams, liver, and oysters, but most people are not in that position.
    • 13 May 2019 · Vitamin B6 · neutral · YouTube ↗
      Mentions vitamin B6 as another example where the principle of metabolic conversions from plant to animal forms applies, with genetic variations affecting the ability to get B6 from plant foods.
  • Andrew Huberman · Vitamin B12 · neutral
    • 15 Dec 2025 · neutral · YouTube ↗
      States that a deficiency in vitamin B12 can be terrible and lead to chronic fatigue-like syndromes, as many parts of mitochondria require B vitamins.
    • 7 Oct 2024 · recommends · YouTube ↗
      Recommends taking methyl B12 as part of methylated B vitamins to lower homocysteine levels and reduce cardiovascular risk.
    • 7 Oct 2024 · Vitamin B2 · neutral · YouTube ↗
      Mentions that Riboflavin (Vitamin B2) hits cytochrome 2 in the mitochondrial electron transport chain, contributing to energy production.
    • 29 Jul 2024 · uses · YouTube ↗
      Has been taking AG1 for over 10 years, once and often twice every day, to ensure he gets all necessary vitamins, minerals, probiotics, and adaptogens, considering it a nutritional insurance policy.
    • 29 Jul 2024 · Vitamin B6 · warns · YouTube ↗
      Does not supplement B6 due to evidence that overs-supplementing vitamin B, especially B6, is problematic because of peripheral nerve damage.
    • 24 Apr 2024 · recommends · YouTube ↗
      Has been taking AG1 since 2012 to ensure he gets enough vitamins, minerals, Prebiotic fiber, and other nutrients typically found in fruits and vegetables, providing nutritional insurance.
    • 23 Oct 2023 · uses · YouTube ↗
      Andrew Huberman started drinking AG1 in 2012 and still drinks it once or twice a day because it provides all his foundational nutritional needs, ensuring proper amounts of vitamins, minerals, probiotics, and fiber for optimal mental health, physical health, and performance.
    • 12 Jun 2023 · Vitamin B6 · neutral · YouTube ↗
      Notes that some people are exploring the use of P5P, a metabolite of vitamin B6 known to suppress prolactin, as a way to buffer the post-MDMA crash, though there are no human data yet.
    • 22 Aug 2022 · recommends · YouTube ↗
      Recommends the consumption of B12 and other B vitamins, especially folate, as it has been shown to partially decrease cancer risk in people who ingest alcohol, though it does not completely offset it.
    • 18 Apr 2022 · uses · YouTube ↗
      Started taking AG1 in 2012 and still takes it once or twice a day because it covers foundational vitamin, mineral, and probiotic needs, and supports immune system function and a healthy gut microbiome.
    • 11 Apr 2022 · Vitamin B6 · recommends · YouTube ↗
      Recommends P5P, which is vitamin B6, as a dopamine agonist to help with low drive and motivation.
    • 17 May 2021 · uses · YouTube ↗
      He has been using Athletic Greens for over a decade to cover his vitamin and mineral bases and support his gut microbiome, immune system, gut-brain axis, and mental functions.
    • 12 Apr 2021 · Vitamin B6 · neutral · YouTube ↗
      Described how some people take vitamin B6 to reduce prolactin levels and thereby reduce the duration of the refractory period, but he is not suggesting anyone do this.
    • 22 Mar 2021 · Vitamin B6 · neutral · Podcast ↗
      Mentions Vitamin B6 as a mild prolactin inhibitor.
  • Dr. Rhonda Patrick · Vitamin B12 · warns
    • 8 Oct 2025 · warns · Facebook ↗
      Warns that Vitamin B12 enhances light's melatonin-suppressing effects and should be avoided too close to bedtime.
    • 9 Apr 2016 · recommends · YouTube ↗
      Notes that a med can cause vitamin B12 deficiency, especially as absorption decreases with age, and suggests a sublingual form or B12 injections for older individuals.
    • 23 Jan 2016 · uses · YouTube ↗
      Discusses the origin of Vitamin B12, suggesting it's a microorganism that propagates in the soil and that animals get it from eating dirt, which is why it's less available in modern, sanitized plant foods.
    • 19 Mar 2015 · Vitamin B6 · recommends · YouTube ↗
      Dr. Patrick states that people with a specific gene polymorphism in the NPF3 gene, which affects vitamin B6 levels, may need to increase their dietary intake of B6 and/or supplement with vitamin B6.
    • 22 Jun 2014 · Vitamin B6 · recommends · YouTube ↗
      Vitamin B6 can suppress the production of Advanced Glycation End products.
    • 17 Feb 2014 · recommends · YouTube ↗
      Describes a study where female mice fed a diet high in B vitamins, folic acid, and vitamin B12 three weeks before pregnancy had offspring that no longer had yellow fur and were not predisposed to obesity and cancer.
    • Date not recorded · neutral · Website ↗
      Dr. Rhonda Patrick explores vitamin B12 and autism risk.
    • Date not recorded · uses · Website ↗
      She takes methyl B12 as part of her Thorne multivitamin, which helps keep her homocysteine levels below 9 micromoles per liter.
    • Date not recorded · neutral · Website ↗
      Describes a study where female mice fed a diet high in B vitamins, folic acid, and vitamin B12 had offspring that silenced a gene predisposing them to obesity and cancer.
    • Date not recorded · uses · Website ↗
      Supplements with vitamin B12, but also notes many of the foods he eats are fortified with it, and his levels are fine.
    • Date not recorded · Vitamin B6 · neutral · Website ↗
      Dr. Rhonda Patrick explores high-dose vitamin B6.
    • Date not recorded · Vitamin B6 · neutral · Website ↗
      Notes that very high doses of vitamin B6 can overcome a specific mutation in the ornithine aminotransferase enzyme, preventing progressive blindness.
  • Bryan Johnson · Vitamin B12 · uses
    • 5 Jun 2025 · uses · YouTube ↗
      States that Blueprint essential capsules and soft gels are packed with key vitamins and minerals needed for strong bone health.
  • Peter Attia · Vitamin B12 · neutral
    • 9 Sep 2024 · neutral · YouTube ↗
      Notes that deficiencies in certain vitamins and minerals, such as B12, can be a cause of hair loss in women.
    • 31 Dec 2019 · uses · YouTube ↗
      Explains that when a person is not responding to traditional B vitamins, they will step it up and give them methylcobalamin B12.
    • Date not recorded · warns · Website ↗
      Notes that Ryan Lochte was suspended for a doping rule violation after a social media post showed him taking vitamin B12 in an illegal way, by IV infusion.

RAL Summary

Members OnlyTier 4 for Energy

Tier 4 fits because no human studies on energy were given for its ingredients and there are no counted reviews, so the evidence is too thin to rank it higher.

  • Emerging: not enough evidence to rank higher yet.
  • No human studies on this goal for its ingredients.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Nervous system, Digestive system

Combine with: For its actual purpose (energy and focus), this drink pairs well with L-theanine to smooth caffeine jitters, magnesium glycinate for muscle and nervous system support, and electrolytes plus water for hydration. Adaptogens such as rhodiola or ashwagandha can support stress resilience, and CoQ10 or creatine can add cellular energy support. Limit total daily caffeine to about 400 mg. For heartburn, use a proper antacid (calcium carbonate or magnesium/aluminum hydroxide) or an alginate such as sodium alginate for fast relief instead, and avoid taking this drink on an empty stomach or close to bedtime. If heartburn is frequent (more than twice a week), see a healthcare provider.

Possible side effects: No study side effects were given; the limited feedback mentions possible stomach upset from sugar alcohols, a faint sweetener aftertaste, and feeling too stimulated later in the day for people sensitive to caffeine.

Supplement Facts

Total Carbohydrates 1 g · Vitamin B2 1.7 mg · Vitamin B3 20 mg
Supplement Facts
Serving Size 8 fl. Oz.
Servings Per Container 2
Amount Per Serving% Daily Value
Calories0
Total Carbohydrates1 g
Vitamin B21.7 mg
Vitamin B320 mg
Vitamin B62 mg
Vitamin B126 mcg
Sodium180 mg
Energy Blend1,400 mg†
† Daily Value not established.

Label source: NIH label database · Report a label change

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Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.