NAKED Lemon Lime Creatine Hydrate+ Powder | Naked Creatine Hydrate+ - 500g Review
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Study, Trial or Testing Result Summary
Members Only31 human studies · 13 improved
This is a creatine powder with small amounts of potassium and magnesium. None of its ingredients has direct study support for thyroid health at the amounts given. The potassium studies that showed thyroid benefits used potassium as a carrier for iodine or bromide, and the benefit came from those, not from potassium itself [1][2][3]. Potassium given without iodine or bromide did not change thyroid hormones. The magnesium here is 20 milligrams, far below the 250 milligrams used in a trial where magnesium combined with zinc and vitamin A raised thyroid hormone in people with an underactive thyroid [4]. A pooled review found the same combination helpful, but magnesium was not tested on its own [5]. One small study found magnesium alone raised active thyroid hormone, but at a much larger dose based on body weight [6]. Magnesium taken together with a thyroid hormone tablet reduced its absorption, so people on meds should take them at separate times [7]. No human studies of creatine for thyroid health were provided. Animal and cell studies are never counted.
See all 31 studies →Hide the studies
- Across 35 trials of 3,508 people with underan underactive thyroid, adding zinc, magnesium and vitamin A to a med raised free thyroxine compared with placebo, but magnesium was not tested on its own.Additional treatment strategies for hypothyroidism: a network meta-analysis.
- In a pooled analysis of 21 trials in people with Graves hyperthyroidism, adding potassium bromide to methimazole ranked best for lowering thyroid hormones at 1 month, though this was a ranking and not a direct comparison.THERAPEUTIC EFFECTS OF COMBINATION REGIMENS INCLUDING METHIMAZOLE ON GRAVES HYPERTHYROIDISM: A NETWORK META-ANALYSIS OF …
- A review of 11 studies found inconsistent results for magnesium and other vitamin and mineral supplements and thyroid cancer risk, so no protective or harmful effect could be concluded.Vitamin and mineral supplements and thyroid cancer: a systematic review.
- In 377 iodine-deficient Moroccan schoolchildren given salt with iodine as potassium iodide plus iron for 9 months, thyroid size and urinary iodine improved in both the iron-added and iodine-only salt groups, so the iron did not change the thyroid benefit.Dual fortification of salt with iodine and microencapsulated iron: a randomized, double-blind, controlled trial in Moroc…
- In 180 pregnant women with mild iodine deficiency, 100 mcg of potassium iodide daily until term reduced thyroid stimulation and limited thyroid growth compared with placebo, and newborns had normal thyroid volume.A randomized trial for the treatment of mild iodine deficiency during pregnancy: maternal and neonatal effects.
- In 158 iodine-deficient children given salt with iodine as potassium iodate plus iron for 10 months, thyroid volume and urinary iodine improved in both groups, so adding iron made no difference to the thyroid result.Dual fortification of salt with iodine and micronized ferric pyrophosphate: a randomized, double-blind, controlled trial…
- In 112 mildly iodine-deficient adults, 150 mcg of iodine as potassium iodate daily for 24 weeks lowered thyroglobulin by 27% compared with placebo, with no change in thyroid-stimulating hormone or free thyroxine.Iodine Supplementation of Mildly Iodine-Deficient Adults Lowers Thyroglobulin: A Randomized Controlled Trial.
- In 90 pregnant women, 225 mcg of potassium iodide daily from early pregnancy to 8 weeks after delivery lowered thyroglobulin late in pregnancy and thyroid-stimulating hormone after delivery, and caused no harm to thyroid function, though thyroid growth differences were small.The Effects of Iodine Supplementation in Pregnancy on Iodine Status, Thyroglobulin Levels and Thyroid Function Parameter…
- In 86 adults with an underactive thyroid, 10 weeks of daily magnesium 250 mg combined with zinc and vitamin A raised free thyroxine and lowered a blood marker of inflammation versus placebo, with no change in thyroid-stimulating hormone.Randomized Study of the Effects of Zinc, Vitamin A, and Magnesium Co-supplementation on Thyroid Function, Oxidative Stre…
- In 80 adults with benign cold thyroid nodules, potassium iodide at 2 mg every 2 weeks for 1 year shrank nodules by 23% on average (not clearly significant), and 5 of 25 had a 50% or greater reduction, whereas untreated nodules grew slightly.Read the study on PubMed (7985890) →
- In 62 very low birth weight infants fed fortified human milk for 6 weeks, higher trace element and magnesium intake did not show a reported thyroid benefit; thyroid results were not described as different.Nutrition of very low birth weight infants fed human milk with or without supplemental trace elements: a randomized cont…
- In 62 people having thyroid surgery, 2 weeks of magnesium 300 mg plus calcium before surgery gave somewhat higher calcium levels and fewer low-calcium symptoms than no supplements, but the differences were not statistically significant.Impact of Preoperative Calcium and Magnesium Supplementation on Quality of Life and Hypocalcemia Post-Thyroidectomy.
- In 60 people with Graves' disease, adding potassium bromide (3 g a day) to methimazole for one month brought thyroid hormones back to normal in 93% (28 of 30) versus 37% (5 of 30) with methimazole alone, and symptoms improved about 10 days sooner.Short-term effects of combined treatment with potassium bromide and methimazole in patients with Graves' disease.
- In 50 healthy volunteers, 10 potassium iodide iontophoresis treatments of the throat did not change thyroid hormone levels compared with galvanization alone over 2 weeks to 6 months, and levels stayed normal.The effect of galvanization and potassium iodide iontophoresis of the throat and larynx on thyroid parameters: a randomi…
- In a 4-week randomized trial of 40 adults, a hydration drink containing electrolytes and amino acids showed no meaningful change in thyroid hormone levels compared with placebo; it was designed to test safety, not thyroid health.Randomized Trial to Assess the Safety and Tolerability of Daily Intake of an Allulose Amino Acid-Based Hydration Beverag…
- In 30 overweight women on a low-calorie diet for 8 weeks, mineral tablets containing potassium and other phosphates kept blood triiodothyronine levels from dropping compared with placebo, and raised resting metabolic rate.Phosphate supplementation prevents a decrease of triiodothyronine and increases resting metabolic rate during low energy…
- In 14 patients with overactive thyroid goiter, potassium iodide solution or iopanoic acid for 7 to 15 days lowered thyroid hormone levels before surgery, with iodine reducing thyroid enzyme activity.Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic …
- In 13 healthy volunteers, six months of daily potassium perchlorate at 0.5 or 3 mg had no effect on thyroid hormones, thyroid iodine uptake, or thyroglobulin compared with placebo.Effects of six months of daily low-dose perchlorate exposure on thyroid function in healthy volunteers.
- In a randomized trial of premature newborns born before 28 weeks, potassium iodide at 30 micrograms per kg daily for 42 days did not raise thyroid hormone levels, unlike the thyroid hormone treatment arms.Phase 1 trial of 4 thyroid hormone regimens for transient hypothyroxinemia in neonates of <28 weeks' gestation.
- In 108 people with endemic goitre, goitre size shrank over 6 months in all active treatment groups including potassium iodide but not with placebo, though 8 of 30 people given potassium iodide developed thyroid antibodies versus 1 of 22 not given it.Treatment of endemic goitre with iodine and thyroid hormones, alone or in combination. (Preliminary report).
- In 40 people with Hashimoto's thyroiditis given 250 mcg of potassium iodide daily for about 4 months, 8 developed an underactive thyroid (7 mild) and 1 an overactive thyroid, compared with 1 of 43 untreated controls.Effect of small doses of iodine on thyroid function in patients with Hashimoto's thyroiditis residing in an area of mild…
- In 68 treatments of patients receiving radioactive iodine-lipiodol for liver cancer, 100 mg a day of potassium iodide from 2 days before to 2 weeks after lowered thyroid radioactive iodine uptake (0.23% vs 0.42%) and thyroid radiation dose (5.5 vs 11.9 Gy) compared with no potassium iodide.Thyroid uptake and radiation dose after (131)I-lipiodol treatment: is thyroid blocking by potassium iodide necessary?
- In a 4-week study of sedentary people and Tae-Kwon-Do athletes, 10 mg/kg daily of magnesium raised free T3 and prevented the exercise-related drop in thyroid hormone activity.The effects of magnesium supplementation on thyroid hormones of sedentars and Tae-Kwon-Do sportsperson at resting and ex…
- In 122 adults newly diagnosed with mild Graves disease, potassium iodide at 50 to 100 mg per day brought thyroid levels under control in about 58 percent of patients, and was judged safe.Therapeutic efficacy and limitations of potassium iodide for patients newly diagnosed with Graves' disease.
- In 20 patients with amiodarone-induced thyrotoxicosis, 1000 mg per day of potassium perchlorate with methimazole for a month brought thyroid hormones to normal or significantly lower in 12 patients, and adding prednisolone helped the rest.A stepwise approach to the treatment of amiodarone-induced thyrotoxicosis.
- In a crossover study of 15 healthy adults, taking magnesium aspartate with a med tablet reduced a med absorption by 12%, and magnesium citrate reduced it by 7% without statistical significance, so the two should be taken apart.Read the study on PubMed (41221788) →
- In 9 healthy adults given potassium bicarbonate for 7 days in place of potassium chloride to neutralize dietary acid, thyroid hormone levels did not change significantly.Neutralization of Western diet inhibits bone resorption independently of K intake and reduces cortisol secretion in huma…
- In a large cohort of 566,398 adults followed for years, dietary magnesium intake was not associated with thyroid cancer risk.The association between selenium and other micronutrients and thyroid cancer incidence in the NIH-AARP Diet and Health S…
- In 55 patients with amiodarone-induced overactive thyroid, a color ultrasound of the thyroid distinguished the two subtypes, but this diagnostic study did not test potassium treatment effects.Thyroid color flow doppler sonography and radioiodine uptake in 55 consecutive patients with amiodarone-induced thyrotox…
- In a 1953 study of people from an area with endemic goitre in Argentina, one patient taking 1,500 micrograms of iodide daily developed an overactive thyroid after 32 days; this study concerned iodide, not potassium.Preliminary studies of iodine metabolism in patients from an area of endemic goitre.
- In a study of how fast the thyroid hormone thyroxine is broken down in healthy adults, potassium iodide given as a single dose produced no detectable change in that rate.A new method for the measurement of acute alterations in thyroxine deiodination rate in man.
Review Totals and Summary
Members Only190 reviews · 85% positive
Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.
Biohacker Summary
Members Only0 of 10 recommend it
Potassium is the main ingredient, and six of the ten panelists recommend it or use it, though their reasons differ. Several say most people do not get enough, with one noting that many get too little compared with the daily target, and another saying people take in too much sodium and too little potassium. Two of them use electrolyte drinks that combine sodium, potassium and magnesium, one to stay hydrated when fasting or exercising, and another says potassium helps creatine reach the brain. One panelist prefers getting potassium from foods like bananas and potatoes rather than supplements, one only lists food sources, and one warns about a potassium additive used in bread. Magnesium and creatine are smaller ingredients in this product, and the panel mostly speaks well of both, with magnesium glycinate favored for sleep and creatine often taken at 5 grams a day.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Potassium · recommends
- Recommends potassium as an important electrolyte, noting that most people get less than half of the 4700 mg RDA.
- Recommends Magnesium glycinate, noting its high absorption rate compared to magnesium oxide, and its support for energy, sleep, muscle relaxation, and vitamin D function.
- Dr. Berg states that when nutrients like magnesium are too low, fatigue and weakness can follow.
- Recommends focusing on magnesium to support stronger bones if a neck hump is associated with osteoporosis.
- Explains that leg and calf cramps are most often caused by low magnesium, with leafy greens being a top source.
- States that magnesium is a cofactor that allows B1 to work more efficiently.
- Highly recommends 5g per day of creatine monohydrate, noting that it may be one of the fastest acting meds ever studied and can improve depression by addressing the brain's energy failure.
- States that magnesium is the most important mineral for energy production, as one cannot make energy without it.
- Recommends creatine, especially for brain energy, memory, focus, concentration, and reaction time, noting that plant-based diets provide almost zero dietary creatine.
- Magnesium is involved in 300 to 600 enzyme reactions, acts as a biological brake pedal, is the master controller over calcium, and is involved in making ATP, the energy currency of the body. It takes energy to go to sleep, and magnesium is required for relaxation and good sleep. Magnesium also helps balance cortisol levels and calm you.
- Dr. Eric Berg states that magnesium supports energy, muscle function, and sleep, and that most of it is stored inside cells, making deficiencies harder to detect with a standard blood test.
- States that people need more potassium than any other mineral, yet most people aren’t getting enough.
- Explains that potassium is essential for peristalsis, the pumping action through the colon, and without it, things can sit there, leading to constipation.
- Notes that magnesium could also be a factor in preventing muscle cramps.
Dave Asprey · Potassium · recommends
- Explains that potassium helps open a gate, allowing creatine to slip through and cross the blood-brain barrier more effectively.
- Looks at magnesium alongside protein to keep muscle for the long run.
- Suggests adding magnesium to help keep potassium in the system longer, as they work hand in hand.
- Dave and Phil examine creatine dosing, hydration, electrolytes, absorption, and why creatine supplementation can influence kidney-related blood test results.
- Loves creatine and believes it is the very best, stating that every study he looks at supports its benefits. He recommends a dose of 5 to 10 grams daily, noting that higher doses are not necessarily more useful for most people and can lead to problems.
- Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
- Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
- Suggests that creatine supports brain health and muscle function.
- Warns that plain creatine can lead to flatness, fogginess, and bloating if hydration and minerals are not dialed in, because it pulls water into muscle cells.
- States that magnesium can affect how the body responds to a supplement.
- Dave and Michael examine emerging research on creatine supplementation and sleep deprivation, including whether creatine can temporarily support cognitive performance after insufficient sleep.
- Warns that while a big dose of creatine can overcome sleep deprivation, using it daily to intentionally sleep only 5 hours is dangerous, as it allows one to push further before hitting a wall, making the eventual crash worse.
- States that creatine is great for the brain and focus, acting like a battery for cells, and he takes it every single morning. He advises taking 10 to 15 grams a day for brain benefits and dissolving it in hot liquid.
- Recommends fixing sleep with 300mg of Magnesium 101 before bed if diet and exercise aren't melting stubborn belly fat.
Thomas DeLauer · Potassium · recommends
- Recommends Element electrolytes, noting they are focused on sodium first, then potassium, then magnesium, helping with sending signals and hydrating tissue.
- Notes that while the body can make creatine, meat eaters have far higher levels because creatine is only found in meats, suggesting that consuming it leads to more optimal levels.
- Recommends taking magnesium glycinate and threonate at night to act as a brake on the nervous system, block excitatory signaling, help wind down, and support serotonin and melatonin production for better sleep.
- Recommends Create's German Creapure creatine, noting it makes his brain feel better and helps him feel more in control on fasting days.
- Mentions that magnesium glycinate also helps a lot with sleep.
- Mentions that restless leg syndrome is often treated with magnesium, but states that the sensation is actually coming from three other issues.
- Is no longer doing super low doses of creatine, finding that the 'magic starts after 10 or 15 g' for fat loss, performance, muscle, strength, and energy. He previously thought low doses were okay but now believes bigger doses are more effective.
- Uses Element's cans which contain 100 milligram potassium, finding that electrolytes help his workout performance.
- Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
- Uses and recommends supplementing creatine to take the burden off the body's natural glycine production, which in turn frees up glycine for other vital functions like sleep and connective tissue repair. He specifically mentions using Klean Athlete's unflavored stick packs and gummies made with pure German Creapure creatine.
- Uses Element's 100 mg potassium cans first thing in the morning to prime his day and help with workout performance.
- Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
- Recommends using Creapure creatine, specifically the powder form during fasting days, to maintain mental alertness and feel more in control.
- Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
Ben Greenfield · Potassium · uses
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Uses magnesium during surgery because it is neuroprotective.
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Discusses a study that suggests creatine causes cancer, but explains why the study's methodology makes its findings not applicable to the average creatine user.
- Mentions magnesium as part of a bare-minimum protocol.
- Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
- States that creatine isn’t a med and that 5g a day builds lean mass safely.
- Notes that in middle-aged and older adults, creatine increases muscle mass even without exercise.
- Notes that creatine is a trending topic regarding its potential to help with the thymus and immunity in general.
- Mentions creatine as something that helps keep healthy mitochondria efficient.
- Recommends Creatine, stating that research supports its use for building up the energy stores muscles use for short, hard efforts like heavy sets.
- States that creatine comes from glycine and arginine, is found naturally in red meat and fish, is not a controlled substance, and no sports organization bans it.
- Uses creatine, specifically Zenos CreaPure gummies, blending four gummies into their smoothie for a total of 10g each morning, noting its benefits for strength, workouts, cognitive performance, skin health, and healthy aging.
- Notes that creatine can help mitigate the negative effects of a caloric deficit on lean muscle mass and metabolism.
Dr. Mark Hyman · Potassium · warns
- Warns that potassium bromate, a dough conditioner banned in the EU, UK, and Canada, is still allowed in U.S. bread.
- Recommends magnesium breakthrough advanced ten from Biooptimizers, which is their most complete magnesium formula with 10 bioavailable forms and 550 milligrams of elemental magnesium, designed to support restful restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
- Explains that a lack of magnesium can cause muscles and nerves to malfunction, resulting in muscle weakness, twitching, and cramps.
- Has her creatine on the counter in the morning, ready to take, so she doesn't have a choice.
- Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
- Includes creatine in a berry smoothie for breakfast.
- Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
- Recommends magnesium as a basic supplement during detoxification to support pathways, help with constipation, and provide electrolytes.
- Includes creatine in their smoothie for muscle and brain support.
- Recommends Magnesium Breakthrough Advanced 10 from Biooptimizers, which contains 10 bioavailable forms and 550 mg of elemental magnesium, to support restful sleep, restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Has recommended magnesium breakthrough from bioptimizers for years and now uses Magnesium Breakthrough Advanced 10 as part of his evening routine, especially during periods of travel, training, and higher stress, to support sleep, muscle recovery, and metabolic health.
- Recommends correcting nutrient deficiencies with magnesium.
- Says creatine is one of the few supplements they return to again and again, supporting the rapid energy system used by muscle, and emerging research is exploring its role in brain health, cognition, and healthy aging.
Siim Land · Potassium · neutral
- Lists potatoes and fruit as sources of Potassium.
- Recommends mixing creatine with water or any beverage, noting that taking it with a meal, especially one with carbohydrates and protein, may slightly increase muscle creatine uptake.
- Recommends taking Creatine any time but warns it might keep you awake if taken too late in the evening.
- Does not take creatine every day because he doesn't want to build more muscle strength, is not deficient in creatine, and is interested in avoiding its VO2 max inhibiting effects.
- States that Magnesium can be a useful addition for some people for sleep.
- Mentions an Alzheimer’s pilot study that found increased brain creatine and improvements in some cognitive test scores after 20 g/day for eight weeks, though it involved only 20 people and no placebo group.
- Recommends magnesium for sleep, especially deep sleep, and suggests trying better types like Threonate, Biscinate, or Torate, referencing a study where magnesium supplementation improved deep sleep.
- States that creatine supports muscle strength, power, and energy availability.
- Recommends Creatine for strength, muscle and cognition, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Recommends Magnesium for blood pressure, migraines and deficiency, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Creatine as one of 15 supplements backed by human studies.
- Lists Magnesium as one of 15 supplements backed by human studies.
- Notes that creatine acts as an energy buffer supplement, increasing exercise capacity, power, and strength, but it doesn't increase mitochondrial count or biogenesis.
- States that magnesium is a fundamental mineral governing over 600 enzymes and metabolic reactions, and recommends that most people need at least 400-500 mg/d for health, with some needing up to 600 mg/d.
Peter Attia · Potassium · recommends
- States there is some evidence that increasing dietary potassium through potassium-rich foods like bananas and potatoes, rather than supplements, can lower blood pressure.
- Peter discusses creatine as a key nutritional factor that supports muscle growth.
- Universally recommends creatine as one of the few supplements that consistently demonstrates benefits for strength, power, and muscle mass, acting as a phosphate donor to generate ATP.
- Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
- Mentions that the full episode covers the benefits of creatine supplementation.
- The episode covers the benefits of creatine supplementation.
- Notes that creatine pulls water into the cell and can help with fluid in the right places, indirectly supporting performance. He also mentions that creatine might benefit women more by reducing actual bloating and pulling water into the cell, especially during the luteal phase.
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Is reloading on creatine and will redo his resting metabolic rate measurement.
- Peter Attia covers creatine supplementation.
- Notes that initial research on creatine's effects on the brain using 5 grams a day did not seem to get creatine into the brain effectively, leading to potentially misleading conclusions in cognition literature.
- Rhonda became fascinated with creatine, a well-studied, safe, and effective supplement for improving exercise performance, and discusses its overlooked benefits for cognition and brain health.
- Warns against creatine gummies, stating that third-party testing found essentially no creatine monohydrate in 95% of them, and that it's challenging to get active ingredients into gummies due to heat degradation and the large amount of gummies needed for an effective dose.
- Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
Andrew Huberman · Potassium · uses
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
- Notes that AG1 Pro contains 5g of creatine monohydrate to support muscle strength, performance, and brain health.
- Notes that Les Spellman's team includes 'Magnesium timed right' as part of their game plan to optimize recovery in unfavorable conditions.
- Discusses creatine in the context of its dose, benefits, and safety.
- Each serving of AG1 Pro has 5 g of creatine monohydrate to support muscle strength and performance, as well as brain health.
- Notes that AG1 Pro contains 5 grams of creatine monohydrate to support muscle strength and performance, as well as brain health.
- Mentions creatine in a discussion about supplement use.
- Discusses Magnesium Threonate as a tool for falling asleep.
- Notes that AG1 Pro contains 5 grams of creatine monohydrate to support muscle strength, performance, and brain health.
- Uses AG1 Pro, which contains 5 grams of creatine monohydrate to support muscle strength, performance, and brain health.
- Ingests 5 grams per day of creatine monohydrate, noting its role in improving cognitive performance by supporting brain networks involved in focus and concentration.
- Notes that AG1 Pro contains 5 grams of creatine monohydrate to support muscle strength, performance, and brain health, and he was already taking some of these ingredients separately.
- Notes that AG1 Pro includes 5 grams of creatine monohydrate, which he was already taking separately, to support muscle strength, performance, and brain health.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
Dr. Rhonda Patrick · Potassium · recommends
- Recommends getting enough potassium, noting that most people get too much sodium and not enough potassium.
- Explains that magnesium helps the body activate and metabolize vitamin D, and that magnesium intake has been associated with lower odds of vitamin D deficiency and insufficiency.
- Mentions that getting too little magnesium may play a role in declining testosterone levels.
- Notes that 20 g/day of Creatine for 8 weeks increased brain creatine by 11% and improved several cognitive measures in a small Alzheimer’s pilot study, calling it promising but preliminary.
- Recommends getting enough magnesium, around 300–400 mg daily from diet and supplements, as it is an essential cofactor for vitamin D metabolism. Magnesium glycinate is a good form.
- Mentions magnesium as one of the micronutrients found in multivitamins that people often don't get enough of from their diets.
- Explains that magnesium helps control blood pressure by boosting the production of substances that relax blood vessels and improve cardiovascular health, citing a meta-analysis that found magnesium supplementation at an average dose of 368 mg per day notably lowers both systolic and diastolic blood pressure.
- Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
- Discusses emerging research on creatine, noting pilot studies where 20g of creatine monohydrate daily for two months improved brain creatine levels and cognitive function in Alzheimer's patients, suggesting it may help a stressed brain.
- Creatine may help women in perimenopause maintain more consistent sleep when combined with strength training.
- Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
- Mentions magnesium as an important nutrient component for testosterone.
- Warns that some supplement companies mislead consumers by listing the total compound weight of magnesium citrate as the elemental magnesium dose, when the actual elemental magnesium content is much lower, potentially around 44-66 milligrams.
- States there is not yet strong, consistent evidence that magnesium supplementation reliably improves sleep, noting that while some meta-analyses suggest it can improve sleep quality scores, sleep efficiency, and sleep duration, individual studies are inconsistent and several have found no meaningful effect.
Bryan Johnson · Creatine · uses
- Takes 5 grams of Creatine in the morning for muscle.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Warns that creatine did not build muscle or burn fat in a study, attributing the observed 'lean mass' increase to water retention rather than new contractile fibers.
- Mentions that $630,000 of elite Blueprint creatine was stolen earlier this year and a new batch just came off the line.
- Takes 5 grams of Creatine in the morning for muscle.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 5 grams of Creatine in the morning for muscle.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- He takes 5 g of Creatine in the morning for muscle.
- He takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 5 grams of Creatine in the morning for muscle.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 5 grams of Creatine in the morning for muscle.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
RAL Summary
Members OnlyTier 4 for Thyroid Health
The tier 2 grade rests on potassium iodide, iodate and bromide studies whose thyroid effects come from the iodine or bromide, not from plain potassium as in this creatine product, so no full-dose ingredient has thyroid evidence. So it is graded Tier 4, lower than the rules alone gave.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 16 of the 31 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Endocrine system, Muscular system
Combine with: Combine with a healthy diet and lifestyle.
Possible side effects: No major side effects reported in the reviews; magnesium taken at the same time as thyroid hormone tablets can lower their absorption.
Supplement Facts
Magnesium 20 mg · Potassium 200 mg · Creatine Monohydrate 5 g
| Calories | 5 | |
| Total Carbohydrate | 1 g | |
| Magnesium | 20 mg | |
| Sodium | 480 mg | |
| Potassium | 200 mg | |
| Creatine Monohydrate | 5 g | † |
Other ingredients: Lemon Juice Powder, Citric Acid, Lemon Extract, Reb M, Maltodextrin.
Barcode (UPC) 850083092313 · Label source: Reverseagelab · Report a label change
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