Nature Made Advanced Hair, Skin & Nails Gummies Review
Product Focus: Thyroid HealthAlso covers:Hormones
Tier ⓘ
Tier 4 · Rank 6
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 6 within Tier 4 for Thyroid Health; 32 of 60 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
15 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Biohacker Mentions
0 of 10
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Study, Trial or Testing Result Summary
Members Only54 human studies · 16 improved
1 of these 54 human studies gave the ingredient by drip, not by mouth.
54 human studies16 improved29 no effect581,889 people studied
No human study shows that this product, or its main ingredient biotin, improves thyroid health. The only biotin study found that high biotin levels distorted thyroid blood test results, which could mislead diagnosis, so tell your doctor before thyroid blood work [1]. Vitamin A is here at 900 mcg, far below the 25,000 units daily that lowered thyroid-stimulating hormone in women [2]. The other positive vitamin A trials used large doses in children low in vitamin A [3][4]. Vitamin C is a trace amount next to the 500 mg studied, and a placebo-controlled trial at that dose found no thyroid benefit [5]. Vitamin E alone did not change thyroid hormones in older adults [6] or students [7]. Its one positive result came only when combined with selenium [8]. No human study shows niacin helps the thyroid, and very high doses lowered thyroid hormone levels without causing disease [9]. Overall, the evidence for thyroid health is thin. Animal and cell studies are never counted.
See all 54 studies →Hide the studies
- In a pooled analysis of 35 trials with 3,508 people with underactive thyroid, adding zinc, magnesium and vitamin A to a med raised free thyroxine compared with placebo, though exercise combined with a med did best for thyroid-stimulating hormone and quality of life.Additional treatment strategies for hypothyroidism: a network meta-analysis.
- A review of 11 studies found conflicting results for vitamin A supplements and thyroid cancer risk, so the evidence was inconclusive.Vitamin and mineral supplements and thyroid cancer: a systematic review.
- A review of 57 studies on micronutrients and thyroid hormones found trials did not confirm links between selenium, zinc and iron and iodine status, and concluded more research is needed; vitamin A was not singled out with a clear result.Micronutrients, iodine status and concentrations of thyroid hormones: a systematic review.
- In 404 South African children aged 5 to 14 with low vitamin A and iodine, a 200,000 IU vitamin A dose given at the start and at 3 months over 6 months lowered thyroid-stimulating hormone, thyroglobulin and thyroid size when given without iodine, compared with placebo.Vitamin A supplementation in iodine-deficient African children decreases thyrotropin stimulation of the thyroid and redu…
- In 138 Moroccan children with goiter and low vitamin A using iodized salt, 200,000 IU of vitamin A at start and 5 months over 10 months reduced thyroglobulin, thyroid-stimulating hormone and goiter rate compared with placebo.The effects of vitamin A deficiency and vitamin A supplementation on thyroid function in goitrous children.
- In 102 people with autoimmune thyroiditis, 500 mg of vitamin C daily for 3 months lowered thyroid antibody levels within the group, but there was no significant difference compared with placebo, and thyroid stimulating hormone did not change.Effects of selenium and vitamin C on the serum level of antithyroid peroxidase antibody in patients with autoimmune thyr…
- In 90 people with heart disease living at altitude, 6 months of selenium plus vitamin E (42 people) lowered raised thyroid hormone levels back to normal in about 74% of them, but vitamin E was not tested on its own, so its separate effect is unclear.[Influence of oral sodium selenite and vitamin E on thyroid hormones in patients with cardiovascular disease at altitude…
- In 89 people with thyroid cancer given radioactive iodine treatment, those taking vitamin E showed better left parotid gland excretion function a month later, though other salivary gland measures were unchanged or worse and the dose was not stated.Effect of vitamin E and supragingival scaling on salivary gland function in patients with differentiated thyroid cancer …
- In 88 healthy adults over 65, 4 months of vitamin E at 60, 200 or 800 IU a day did not change thyroid hormones or thyroid antibodies compared with placebo.Assessment of the safety of supplementation with different amounts of vitamin E in healthy older adults.
- In 86 adults with underactive thyroid, 25,000 IU vitamin A twice weekly with zinc and magnesium for 10 weeks raised free thyroxine and lowered an inflammation marker compared with placebo, with no change in thyroid-stimulating hormone.Randomized Study of the Effects of Zinc, Vitamin A, and Magnesium Co-supplementation on Thyroid Function, Oxidative Stre…
- In 84 women, 25,000 IU of vitamin A daily for 4 months lowered thyroid-stimulating hormone in both obese and non-obese women and raised T3, while total T4 fell.The effect of vitamin A supplementation on thyroid function in premenopausal women.
- In 82 people with thyroid cancer given radioactive iodine, vitamin E at 100 to 300 mg a day from 1 week before to 4 weeks after treatment protected the salivary glands better than no vitamin E; thyroid function itself was not measured.Radioprotective effect of vitamin E on salivary glands after radioiodine therapy for differentiated thyroid cancer: a ra…
- In 80 postmenopausal women with or without type 2 diabetes, 6 weeks of hormone therapy with vitamin C and E did not significantly change free thyroxine or triiodothyronine levels.Effects of hormone replacement therapy with vitamin C and E supplementation on plasma thyroid hormone levels in postmeno…
- In 69 thyroid cancer patients given radioactive iodine, vitamin E with vitamin C improved the function of one parotid salivary gland, with no placebo group and no thyroid outcomes; selenium groups showed more gland improvements.Effects of postoperative antioxidants on the salivary glands in patients with thyroid cancer undergoing radioactive iodi…
- In 57 people with Graves' disease on methimazole, an antioxidant mix with beta-carotene, vitamins C and E and selenium over 60 days helped them reach normal thyroid function faster than the drug alone.Supplementation with antioxidants in the treatment of Graves' disease; the effect on glutathione peroxidase activity and…
- In 55 people with Graves' disease taking methimazole, adding an antioxidant mix (vitamins C and E, beta-carotene and selenium) for 60 days helped them reach normal thyroid function faster than methimazole alone.The effect of antioxidant supplementation on superoxide dismutase activity, Cu and Zn levels, and total antioxidant stat…
- In 49 women with iron deficiency, 60 days of a multi-nutrient supplement containing vitamin E improved blood iron and ferritin; thyroid hormones were measured but no thyroid effect was reported.[Effect of treatment with a food supplement (containing: selected sea fish cartilage, vitamin C, vitamin E, folic acid, …
- In 40 people, a hydration drink that also contained vitamin C caused no meaningful change in safety or thyroid hormone measures compared with placebo over 4 weeks, though one thyroid hormone showed a statistically significant main effect.Randomized Trial to Assess the Safety and Tolerability of Daily Intake of an Allulose Amino Acid-Based Hydration Beverag…
- In 36 thyroid cancer patients given radioactive iodine, 800 IU a day of vitamin E from 1 week before to 4 weeks after treatment helped protect salivary gland function compared with placebo; thyroid function itself was not measured.Does vitamin E protect salivary glands from I-131 radiation damage in patients with thyroid cancer?
- In 32 healthy older adults, 800 mg a day of vitamin E for 30 days did not change thyroid hormone levels compared with placebo.Assessment of the safety of high-dose, short-term supplementation with vitamin E in healthy older adults.
- In 31 severely injured patients, adding 150 mg of vitamin E and zinc to 500 mcg of selenium for 5 days gave no extra change in thyroid hormones beyond selenium alone.Influence of selenium supplements on the post-traumatic alterations of the thyroid axis: a placebo-controlled trial.
- In 12 underactive thyroid patients needing high-dose a med, 1 g vitamin C daily for 16 weeks improved symptom scores and lowered thyroid stimulating hormone more than placebo after adjustment, but the very small size and baseline imbalances limit conclusions.Read the study on PubMed (41210509) →
- In 53 patients with mild underactive thyroid and 45 healthy people, vitamin C infused into the forearm artery normalized blood vessel dilation in patients but not in healthy people, suggesting oxidative stress from inflammation impairs vessel function; this was a short-term vessel test, not a supplement trial.Low-grade systemic inflammation causes endothelial dysfunction in patients with Hashimoto's thyroiditis.
- In 19 healthy college students, 14 took 600 mg of natural vitamin E daily for 12 weeks and 5 took placebo, and thyroid function tests did not change.Effects of elevated d-alpha(RRR)-tocopherol dosage in man.
- Niacin at 2 mg was used only as a comparison dose against intravenous TRH in schizophrenic patients, so this study does not measure niacin's own effect on thyroid health.Behavioral and endocrine responses of schizophrenic patients to TRH (protirelin).
- In a small study of 11 iron-depleted women, ascorbic acid supplementation had no significant effect on their responses to cold exposure, which included changes in thyroid hormone levels.Thermogenesis and thermoregulatory function of iron-deficient women without anemia.
- In healthy young and elderly people, 10 days of vitamin A (retinol, 50,000 IU a day) did not significantly change thyroid-stimulating hormone levels compared with placebo.Effects of vitamin A administration on serum thyrotropin concentrations in healthy human subjects.
- In 34 older adults over 6 months, a fruit, vegetable and berry powder that raised blood vitamin C was well tolerated and caused no thyroid-related safety problems, though a marker of protein damage fell before adjustment for baseline differences.Effects of a Commercial Fruit, Vegetable and Berry Juice Powder Concentrate on Metabolic Safety and Cardiovascular Healt…
- In 31 patients with underactive thyroid and gastritis, 500 mg vitamin C taken with a med for 2 months lowered thyroid stimulating hormone in all patients, normalized it in 55%, and raised thyroid hormone levels.Read the study on PubMed (24601693) →
- In 9 people with an underactive thyroid, about 4 months of thyroxine replacement cleared fats from the blood faster after a meal containing vitamin A and lowered LDL cholesterol, though this study did not test vitamin A as a supplement.Thyroxine replacement therapy enhances clearance of chylomicron remnants in patients with hypothyroidism.
- In five people with high cholesterol taking about 2.6 grams of nicotinic acid daily for an average of 1.3 years, blood thyroid hormone levels dropped (total T4 by 21%, T3 by 13%) while they stayed in a normal thyroid state with no symptoms of an underactive thyroid.Nicotinic acid decreases serum thyroid hormone levels while maintaining a euthyroid state.
- In a University of Southern California study, people who took colestipol combined with niacin for one year had lower total thyroxine and lower thyroxine-binding globulin levels, but they stayed essentially normal in thyroid function.Alterations in serum thyroid hormonal indices with colestipol-niacin therapy.
- In a large cohort of over 566,000 adults followed for years, dietary beta-carotene intake was not clearly associated with thyroid cancer risk.The association between selenium and other micronutrients and thyroid cancer incidence in the NIH-AARP Diet and Health S…
- In a survey of 5,878 US adults, higher vitamin C intake was linked to lower total thyroxine levels, with curved patterns for other thyroid hormone measures, so the effect on thyroid function is unclear.Association between vitamin C intake and thyroid function among U.S. adults: a population-based study.
- In a large US national survey of 2,732 adults, dietary vitamin C intake was not significantly associated with risk of Hashimoto's thyroiditis, though higher omega-3 fat intake was linked to lower risk.Investigating the associations between dietary nutrient intake and risk of Hashimoto's thyroiditis: a cross-sectional st…
- Pregnant women with iodine insufficiency had lower alpha-tocopherol (vitamin E) levels than those with adequate iodine, with no change in thyroid stimulating hormone.Assessment of thyroid function, ioduria and oxidative stress in women in the first trimester of pregnancy.
- In a questionnaire survey of 232 Polish people with hypothyroidism, vitamin C was among the supplements commonly taken, but the survey did not measure whether it improved thyroid health.Dietary supplements in hypothyroidism.
- In a blood metabolite comparison of 80 people with papillary thyroid cancer and 80 healthy controls, alpha-tocotrienol (a form of vitamin E) was higher in the cancer group. This was an association only and did not involve vitamin E supplementation.Serum Metabolomics Study of Papillary Thyroid Carcinoma Based on HPLC-Q-TOF-MS/MS.
- Serum vitamin E tracked with lipid peroxides, and both were lower in malnourished people and people with thyroid disorders than in healthy adults.Serum vitamin E and lipid peroxides in malnutrition, hyper and hypothyroidism.
- A dietary survey of 103 schoolchildren in Adygea found insufficient intake of iodine, zinc, vitamin A and beta-carotene, and the authors concluded that low vitamin A and zinc intake may contribute to iodine deficiency and thyroid problems, but no supplement was tested.[Assessment of the structure and quality of nutrition as a factor that influences thyroid functional activity].
- In a cross-sectional study of 92 women with Hashimoto's thyroiditis, higher dietary vitamin C intake was weakly linked to lower thyroid antibody levels (r = -0.22, p = 0.05), but this was one of several correlations and does not show cause and effect.Parallel investigation of oxidative stress and nutritional profile in women with Hashimoto's thyroiditis.
- In 90 patients with thyroid cancer, alpha-tocopherol (vitamin E) was one of several metabolites that distinguished those with lymph node spread from those without.Gut microbiota and metabolite profiles in thyroid cancer lymph node metastasis: a multi-omics analysis.
- In 34 people with phenylketonuria or milder high phenylalanine and 42 healthy controls, blood alpha-tocopherol (vitamin E) levels did not differ between groups, even though selenium was lower in the patients and thyroid hormone status was altered.Antioxidant and thyroid hormone status in selenium-deficient phenylketonuric and hyperphenylalaninemic patients.
- In 20 people with an underactive thyroid, 20 with an overactive thyroid and 20 healthy controls, blood vitamin E was raised in the underactive group and returned to control levels after 2 months of treatment. Oxidative stress markers also fell with treatment in the overactive group. Vitamin E was not supplemented.The effect of hypothyroidism, hyperthyroidism, and their treatment on parameters of oxidative stress and antioxidant sta…
- This observational study of 58 overweight or obese adults did not test vitamin E as a treatment; it only found that people with food addiction reported higher intake of gamma-tocopherol, a form of vitamin E, and had lower TSH, a thyroid hormone, than those without food addiction.Hormonal and dietary characteristics in obese human subjects with and without food addiction.
- LDL vitamin E was lower in hypothyroid patients than in healthy controls, while LDL oxidation was higher in both hyperthyroid and hypothyroid patients.Effect of thyroid function on LDL oxidation.
- In a cross-sectional study of 46 papillary thyroid cancer patients, higher vitamin E intake was linked to a lower rate of lymph node spread, though this does not prove vitamin E causes the benefit.Histopathological prognosis of papillary thyroid carcinoma associated with nutritional status of vitamins A and E.
- In 20 people with overt hypothyroidism, serum vitamin E was higher than in controls and correlated with markers of oxidative stress.Association between thyroid hormones, lipids and oxidative stress biomarkers in overt hypothyroidism.
- In 28 adults taking 100 to 800 IU of vitamin E daily for about 3 years, blood tests of the thyroid gland showed no disturbance, though no placebo group was used.Megavitamin E supplementation in man.
- In a case series of 22 surgical patients with low vitamin C or thiamin and raised TSH, two patients died from scurvy, and no vitamin C treatment effect on thyroid function was studied.Hypothyroidism Complicated by Vitamin C and Thiamin Deficiency in Surgical Patients.
- Over about 96 days at sea in 17 crew members, blood alpha-tocopherol (vitamin E) stayed stable during the first phase of hard work and a high-fat diet, while TSH rose. Vitamin E was not supplemented.Metabolic adaptation in the crew of the Hesperides on their Antarctic journey.
- In 50 children with biotinidase deficiency taking 5 to 20 mg of biotin daily, high biotin levels distorted thyroid stimulating hormone and other hormone blood tests run on one Roche assay system, so these lab results can mislead diagnosis, while removing the biotin from the sample corrected the error.Serum biotin interference: A troublemaker in hormone immunoassays.
- In 40 thyroid cancer patients receiving radioiodine, taking 1000 mg of vitamin E with vitamin C and selenium for 21 days beforehand reduced the rise in a blood marker of lipid peroxidation, with an average increase of 56% versus 112% in the group without supplements.Radioiodine-induced oxidative stress in patients with differentiated thyroid carcinoma and effect of supplementation wit…
- Five infants aged 8 to 11 months developed yellow skin from eating large amounts of carotene-rich foods, and their thyroid function tests were normal; stopping those foods cleared the yellow color, and the authors described the condition as benign.Benign carotenemia in children.
Review Totals and Summary
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Biohacker Summary
Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it
Vitamin C, a smaller ingredient in this product, is the one the panel talks about most, and most of the panel recommends or uses it. They take it mainly for skin and for making collagen, and several suggest pairing it with collagen, with one advising it about an hour before a workout. Doses they gave range from 250 milligrams to 500 milligrams to 1 gram, and up to 2 to 4 grams for inflammation, and one likes a liquid liposomal form while another prefers applying it to the skin. For caution, one panelist says the best dose is uncertain and high doses might dull some of the benefits of exercise, and one stopped a vitamin C skin serum because of its smell. Vitamin A and vitamin E, also smaller ingredients in this product, drew mostly neutral comments, with a couple recommending real vitamin A or vitamin E, while biotin, another smaller ingredient, was only mentioned by two panelists without advice.
See all 10 biohackers →Hide the biohackers
Ben Greenfield · Vitamin E · neutral
- Mentions a recent study showing no significant increase in bleeding for patients on Vitamin E supplementation during open heart surgery, which was interesting for him to learn.
- States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
- Notes that Vitamin A is a fat-soluble vitamin that supports healthy skin cell turnover.
- Mentions vitamin C as part of a bare-minimum protocol.
- Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
- States that Nrf2 activators, when combined with something like niacin, may have a good effect on plaque progression.
- Notes that IV vitamin C has been used for decades for cancer patients with almost no standardization and that he receives many questions about its effectiveness and combination with chemo.
- Recommends Vitamin C for skin repair post-tattoo.
- Notes a new study indicating that vitamin E is a core dietary antioxidant closely associated with a reduced risk of accelerated biological aging.
- Recommends Xtendlife's Tocotrienols Vitamin E for cardiovascular, brain, and healthy aging support, noting that research points to tocotrienols over alpha-tocopherol.
- Mentions nicotinamide as an ingredient found in many NAD products and notes that niacinamide and nicotinamide are structurally the same.
- Believes the niacinamide approach, along with the NAMPT/salvage pathway angle, is underrated and deserves more attention.
- Recommends vitamin A derivatives like retinol for targeting wrinkles and laxity, as they work deeper without aggravating the surface.
- Does not agree that ascorbic acid is vitamin C, comparing it to calling chaff wheat, and notes that it is made from genetically modified cornstarch or corn syrup byproducts using solvents.
Siim Land · Vitamin C · recommends
- Recommends taking vitamin C with collagen to support joint collagen synthesis.
- States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
- Lists sauerkraut and fruit as sources of Vitamin C.
- Lists liver and carrots as sources of Vitamin A.
- Notes that Vitamin C is one of several supplements with human evidence.
- Notes that researchers found vitamin C alleviates ferro-aging, a process of iron overload and lipid peroxidation that drives aging, and that it directly inhibited ACSL4, a protein driving ferro-aging.
- States that Vitamin C has a central role in aging and longevity, and that in monkeys, oral vitamin C slowed ovarian aging during a 3.3-year study.
- States that vitamin C is one of the most important vitamins for staying healthy and aging well, and that intakes of 200 to 400 mg a day from food or supplements largely saturates plasma and neutrophils in most healthy adults. He also recommends spreading out the vitamin C across the day to avoid oversaturation.
- Notes that oral vitamin E and C supplementation has been noted to increase the dose of UVB radiation from the sun needed to cause redness of the skin, suggesting increased resilience against sun damage. He also mentions a trial where a combination of slow-release vitamin C and vitamin E decreased the progression of carotid atherosclerosis in men.
- Mentions vitamin C in comparison to topical melatonin for oxidative defense, stating that melatonin would compete but is not as broadly validated clinically.
- Mentions vitamin E in comparison to topical melatonin for oxidative defense, stating that melatonin would compete but is not as broadly validated clinically.
- Was found to be vitamin C deficient by True Health and Mayo Clinic tests, and now addresses this by eating one extra kiwi fruit daily.
- States that the biggest evidence for multivitamin is that it improves cognition and enhances episodic memory in elderly people, who tend to have worse diets and are more likely to be deficient.
- States that the biggest evidence for multivitamin is that it improves cognition and enhances episodic memory in elderly people, who tend to have worse diets and are more likely to be deficient.
Dr. Eric Berg · Vitamin C · neutral
- Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
- Dr. Berg states that Vitamin C helps fight biofilms and is essential for making collagen in gums, teeth, and capillaries.
- Recommends Vitamin C as a cofactor, especially for collagen.
- Notes that low vitamin A can lead to dry eyes, dry mouth, and night vision issues.
- States that high doses of vitamin C, like 2 to 4 grams, can greatly reduce inflammation and support the immune system.
- States that expensive NAD+ supplements only turn into $5 niacin in the body and that research has shown niacin can actually raise NAD levels in the blood 5 to 8 times their baseline levels.
- Mentions that grass-fed liver has the active form of vitamin A, called retinol, which is important for eyes, thyroid, immune system, and skin.
- Mentions that grass-fed liver has vitamin E.
- Highly recommends taking natural food vitamin C, about 500 mg, at the first sign of a cold.
- Recommends cheap flush niacin, stating that it outperforms expensive NAD supplements and even IV drips in raising NAD levels in the blood.
- Dr. Berg warns that synthetic vitamin A can cause problems, including competing with vitamin D, increasing the risk of birth defects during pregnancy, and increasing the risk of bone fractures, recommending food sources like egg yolks and cod liver oil instead.
- Dr. Berg states that synthetic vitamin E may be acceptable for short-term use, but long-term use can contribute to oxidative stress.
- Warns against synthetic vitamin E (dl-alpha-tocopherol) for ongoing maintenance, citing a trial where it increased prostate cancer risk and explaining that it can become a free radical and starve out necessary protective forms of vitamin E.
- Mentions vitamin A deficiency as a possibility for dry mouth, but emphasizes that vitamin A doesn't work without zinc.
Thomas DeLauer · Vitamin C · recommends
- Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
- Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
- Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
- Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
- Compares the Vitamin C content of oranges (53mg) to guava (228mg), noting guava has 4x more.
- Uses niacin as part of their detoxification protocol, taking enough to flush about half an hour before a sauna session.
- States that collagen synthesis is vitamin C dependent, in the context of glowing skin.
- Recommends Vitamin C for sleep, noting that intake in the range of 125 to 200 mg per day is associated with a lower risk of sleep disorders and sleep apnea, with the benefit plateauing beyond this range.
- Mentions a causal link found between vitamin E and waking up in the middle of the night.
- Recommends consuming a little bit of vitamin C, such as a couple of berries or kiwi, along with flavanol-rich cocoa to help the delicate flavanols hold up and prevent oxidation in the gut.
- Recommends vitamin A, obtainable from eggs, dairy, and liver, as a raw material for goblet cells to produce mucus.
- Explains that vitamin C improves the ability of neutrophils to engulf bacterial infections, and that they have a greater ability to engulf larger infections.
- Recommends using a multivitamin to ensure adequate micronutrient intake, especially when wholesome food is less available.
- Recommends using a multivitamin to ensure adequate micronutrient intake, especially when wholesome food is less available.
Dave Asprey · Vitamin C · recommends
- Recommends taking vitamin C for better skin health.
- States that currently, he is only taking vitamin C and vitamin D.
- Dave Asprey's kids get a little bit of vitamin E every day, which helps to stabilize the bad oils they get when eating at restaurants.
- Recommends real vitamin A for people on the spectrum, noting that many cannot convert plant vitamin A and need the good stuff he includes in his Vitam DAKNE product.
- Recommends Vitamin E as one of the most important supplements for overall health.
- Dave Asprey reflects on how new research clarifies the mechanism behind IV vitamin C's anti-cancer effect, vindicating a decades-old idea that was dismissed for the wrong reasons.
- Takes Vitamin DAKE from Suppgrade Labs because D3, A, K2, and E work together.
- Takes Vitamin DAKE from Suppgrade Labs because D3, A, K2, and E work together.
- Notes that plain Vitamin C isn't enough and that most people never think to check for a specific ingredient that makes it work.
- Recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish, or from supplements.
- Includes vitamin K2 as a critical ingredient in Vitamin DAKE, stating that the body needs the right fat soluble vitamins for thousands of reactions.
- Includes vitamin K2 as a critical ingredient in Vitamin DAKE, stating that the body needs the right fat soluble vitamins for thousands of reactions.
- Dave Asprey recommends taking maybe a gram of vitamin C a day in divided doses, noting that plasma levels peak around 250 milligrams twice a day.
- Recommends Qualia Vitamin C Plus, highlighting its combination of seven forms of vitamin C with 250 mg of citrus bioflavonoids, which helps with absorption and use for building collagen and a strong immune system.
Dr. Mark Hyman · Vitamin A · neutral
- Mentions that vitamin A levels can be looked at to get a deep sense of what's happening with nutrient levels.
- Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
- Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
- Mentions topical vitamin C as an antioxidant that can help skin with aging.
- Mentions that what they do when a cold comes on is not just vitamin C.
- Recommends taking 50,000 units of vitamin A for three to five days right at the onset of symptoms if one feels they might be getting sick.
- Recommends ensuring adequate vitamin C intake on a regular basis for immune support, stating it's important for healthy immune function despite mixed data on its effectiveness for colds.
- Notes that night blindness is caused by vitamin A deficiency.
- Mentions that vitamin C was the very first vitamin discovered, isolated, and synthesized in 1932, and its deficiency caused scurvy.
- Explains that pellagra, which killed 100,000 Americans, was a niacin deficiency, a B vitamin.
- Recommends nutrient-dense foods rich in vitamin C, such as guavas and parsley, to reduce inflammation.
- Used intravenous vitamin C cocktails to help him detoxify and recover from chronic fatigue.
- Mentions vitamin A as something that might be helpful for gut repair.
- Notes that patients who were very malnourished had extremely low vitamin E.
Dr. Rhonda Patrick · Vitamin E · neutral
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Recommends nutrients like vitamin C for men to prioritize sperm mitochondrial health.
- Dr. Rhonda Patrick's daughter chugs an Emergency fizzy drink in the morning to ensure she gets some vitamin C and micronutrients before school.
- Choosing a multivitamin that includes lutein and zeaxanthin ensures you get meaningful amounts every day.
- Choosing a multivitamin that includes lutein and zeaxanthin ensures you get meaningful amounts every day.
- Choosing a multivitamin that includes lutein and zeaxanthin ensures you get meaningful amounts every day.
- Notes that ~60% of Americans are low in vitamin E.
- Notes that ~35% of Americans are low in vitamin C.
- Recommends increasing vitamin C intake if concerned about skin aging, noting it is an essential cofactor for collagen synthesis.
- Suggests avoiding a multivitamin if it contains biotin before a testosterone blood test to prevent confounding results.
- Suggests avoiding a multivitamin if it contains biotin before a testosterone blood test to prevent confounding results.
- Suggests avoiding a multivitamin if it contains biotin before a testosterone blood test to prevent confounding results.
Andrew Huberman · Vitamin E · uses
- Takes a multivitamin every day for longevity.
- Takes a multivitamin every day for longevity.
- Takes a multivitamin every day for longevity.
- Mentions biotin.
- Recommends AG1, a vitamin, mineral, and probiotic drink, and notes that for a limited time, a subscription comes with additional supplements.
- Takes an extra gram of vitamin C a day for its effects on immunity and potential synergy with collagen.
- Found the Met RX Big 100 Bar to be 'magic' on the trail because it's a hunk of calories with protein and fortified with vitamins and minerals, despite being something they would never eat in normal life.
- Found the Met RX Big 100 Bar to be 'magic' on the trail because it's a hunk of calories with protein and fortified with vitamins and minerals, despite being something they would never eat in normal life.
- Started taking AG1 in 2012 and still takes it every single day to ensure he meets his quota for daily vitamins and minerals and to support gut health, which is critical for proper brain function, immune system, and neurotransmitter production.
- Highlights Vitamin A as essential for vision and recommends it for supporting vision.
- Mentions that the process of converting light into electrical signals in the retina requires vitamin A, a fat-soluble vitamin, and carotenoids, which is why carrots are said to help vision.
- Warns that high-dose supplementation of Vitamin E, when given to lung cancer patients, led to worse outcomes than control subjects, highlighting that it's not the same as ingesting it in food.
- Has been taking AG1 daily since 2012 because it is the highest quality and most complete foundational nutritional supplement, ensuring he gets all necessary vitamins, minerals, and micronutrients for daily health.
- Has been drinking AG1 since 2012, finding it difficult to get enough vitamins, minerals, micronutrients, and adaptogens from diet alone. He finds that taking AG1 daily improves all aspects of his health, including physical and mental health, performance, recovery from exercise, and immune system strength, and also notices more mental clarity and energy.
Peter Attia · Vitamin A · neutral
- Notes that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin A for male mice.
- In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin A for male mice.
- Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
- Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
- Peter Attia's AVIA Skincare vitamin C serum also contains niacinamide, which is useful to apply to the skin right after washing.
- Mentions that a lot of the profound transformation of a cell into a sperm, specifically the making of a tail, is vitamin A driven.
- Warns that biotin, found in many supplements, can completely obscure findings and render a non-LCMS test for estradiol and testosterone irrelevant due to interference with ELISA-based assays.
- Notes that antioxidants like vitamins A, C, and E have been looked at for cataract formation but have shown no effect.
- States that vitamin C deficiency is associated with an elevated risk of cataract, but supplementation to supranormal levels has not been shown to protect against cataract formation.
- Mentions the elimination of scurvy through the work of James Lind and the eventual understanding that it was due to vitamin C, initially thought to be just citrus.
- Notes that there are some downsides to Vitamin E, including cardiovascular longitudinal risk and prostate cancer, and that discussions are needed with patients, especially those with diabetes or cirrhosis, due to studies indicating increased all-cause mortality depending on the dose.
- Advises that if taking a biotin supplement, one should discontinue it for at least a few days, if not a week, before a blood test, as it can dramatically skew thyroid values.
- Warns that certain things, like biotin, should not be taken before a blood test because they can mess up readings.
- Peter Attia, involved in the American Urological Association Peyronie's guidelines, stated that vitamin E is not indicated for Peyronie's disease and should not be given.
Bryan Johnson · Vitamin C · neutral
- Uses Vitamin C as an example of how it would be great if people knew that when they took it, it had a measurable amount and wasn't polluted, which is what Brian ensures with his products.
- Applies vitamin C after showering.
- Mentions biotin as an example of an ingredient that AG1 lists with a specific dose, but then contrasts it with other ingredients in proprietary blends where doses are not disclosed.
- Takes 250 milligrams of Vitamin C.
- Recommends Vitamin C for skin health, noting it's good to pair with collagen peptides and is included in the Blueprint stack.
- Bryan Johnson takes Vitamin C daily as part of his Longevity Mix, which is an antioxidant-rich essential vitamin that supports immune function and metabolic energy.
- He uses Vitamin C, typically in a serum, in the morning for skin health.
- Recommends adequate Biotin (Vitamin B7) for hair health, noting it is in the Blueprint stack.
- Recommends adequate Vitamin E for hair health, noting it is in the Blueprint stack.
- Uses Vitamin E at 10 IU/ML in his custom topical hair formulation.
- Recommends Niacinamide as a supplement for skin health, noting it is in the Blueprint stack.
- He uses Niacinamide, found in serums or moisturizers, morning and night, and takes 15 mg in Blueprint Essential Capsules.
RAL Summary
Members OnlyTier 4 for Thyroid Health
Human studies support Vitamin E (6 of 26 human studies showed an improvement), but there are not yet enough reviews to confirm it (0). The final check notes: The tier is justified by vitamin E support, but trials that gave vitamin E alone found no change in thyroid function and its only positive result came when it was combined with selenium, so the evidence is thin rather than supportive, which still supports tier 4.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 29 of the 54 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Endocrine system
Possible side effects: High biotin can distort thyroid blood test results, making them look abnormal or normal when they are not. Each serving contains 3 grams of added sugar.
Supplement Facts
Includes Added Sugars 3 g · Vitamin A 900 mcg · Vitamin C 45 mg
Supplement Facts
Serving Size 2 Gummies
Servings Per Container 40
Amount Per Serving% Daily Value
| Calories | 15 | |
| Total Carbohydrate | 4 g | |
| Total Sugars | 3 g | |
| Includes Added Sugars | 3 g | |
| Vitamin A | 900 mcg | |
| Vitamin C | 45 mg | |
| Vitamin E | 9 mg | |
| Niacin | 8 mg | |
| Biotin | 6,000 mcg | |
| Sodium | 30 mg |
Other ingredients: Glucose Syrup, Sugar, Water, Gelatin, Less than 2% of Mannitol, Pectin, Sodium Citrate, Palm Oil, Natural Flavors, Carnauba Wax, Citric Acid, Color Added (Including Carmine).
Directions: Adults, consult your physician before use. Chew 2 gummies daily.
Barcode (UPC) 031604006945 · Label source: Reverseagelab · Report a label change
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Our articles on this subject
- Supplement and Medication Interactions You Should KnowArticle · Oct 20, 2026
- What Supplements and Vitamins Should Not Be Taken TogetherArticle · Sep 7, 2026
Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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