Nature Made Magnesium Glycinate 200 mg Review
This Amazon listing sells Nature Made Magnesium Glycinate 200 mg per Serving in a 60 count bottle of capsules, described as a 30 day supply. The product is presented as a high absorption magnesium supplement for muscle, heart and bone support, also labeled as Magnesium Bisglycinate Capsules. The page says the product helps convert food into cellular energy and supports muscle relaxation, bone health, heart health and nerve health. It describes Magnesium Glycinate as gentle on the stomach and as a highly bioavailable, chelated form of magnesium. The listing states that magnesium helps support the production of melatonin. Directions say adults take two Magnesium Bisglycinate Capsules daily with water and a meal to aid absorption. The product is described as gluten-free, with no added color and no artificial flavors. The page calls it the number 1 Pharmacist Recommended Vitamin and Supplement Brand, marked with an asterisk. The product specifications list the item form as capsule, the primary supplement type as magnesium, the flavor as unflavored, and the diet type as gluten free. The item weight is listed as 3.61 ounces, with 1 item and a unit count of 60. The features section adds that the product offers better absorption and better GI tolerance than other magnesium forms such as magnesium oxide, and that it is 100 percent chelated magnesium glycinate. The page notes that the statements have not been evaluated by the Food and Drug Administration and that the product is not intended to diagnose, treat, cure or prevent any disease. The manufacturer is listed as Pharmavite, and the brand is Nature Made. The sold-by and ships-from details name Amazon.com, and the item is non-returnable due to food safety reasons. Other sizes shown on the page are 110 count and 180 count bottles of the same product name. The page shows a rating of 4.6 out of 5 stars from 22,712 ratings. No star histogram or written customer reviews are visible in the scraped text.
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Study, Trial or Testing Result Summary
Members Only53 human studies · 29 improved
6 of these 53 human studies gave magnesium by drip, not by mouth.
This product gives 200 milligrams of magnesium as magnesium glycinate, close to the 226 milligrams that worked in one sleep trial, so it counts as a full dose. The evidence for sleep is mixed. A pooled analysis of three placebo-controlled trials in 151 older adults with insomnia found people fell asleep about 17 minutes faster, but the gain in total sleep was not clear and the evidence was low quality [1]. In 216 people with night leg cramps, 226 milligrams at bedtime for 60 days improved sleep quality more than placebo [2]. In 46 older adults with insomnia, 500 milligrams daily for 8 weeks improved sleep time and time to fall asleep [3]. Other trials found no benefit: 320 milligrams for 7 weeks in 100 poor sleepers did not beat placebo [4], and a 4-week trial in 94 older adults found no difference from placebo [5]. A review of 12 trials called the results inconsistent and low certainty, and did not support magnesium as a routine insomnia treatment [6]. Note that the trials used other forms of magnesium, such as oxide and citrate, not glycinate. Animal and cell studies are never counted.
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- Pooling three placebo-controlled trials in 151 older adults with insomnia, people taking oral magnesium fell asleep about 17 minutes faster than those on placebo, while the 16-minute gain in total sleep time was not statistically significant, and the evidence was low quality.Oral magnesium supplementation for insomnia in older adults: a Systematic Review & Meta-Analysis.
- In a review of 31 trials of sleep supplements, amino acids, melatonin and vitamin D clearly improved sleep quality, but magnesium had too little data to be pooled and was only discussed as possibly helpful.Efficacy of dietary supplements on improving sleep quality: a systematic review and meta-analysis.
- A review of 9 studies with 7,582 adults found observational links between magnesium status and better sleep, but the randomized trials of magnesium supplements gave contradictory, uncertain results.The Role of Magnesium in Sleep Health: a Systematic Review of Available Literature.
- In a review of Crohn's disease studies, low magnesium levels were linked to longer time to fall asleep and shorter sleep, but the review did not directly test magnesium supplements for sleep.Does Magnesium Provide a Protective Effect in Crohn's Disease Remission? A Systematic Review of the Literature.
- In a review of 10 trials of 482 people with restless legs syndrome across all supplements, magnesium oxide improved sleep quality and symptoms, appearing more effective than vitamin B6, though half of the trials had a high risk of bias.Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review.
- In a review of treatments for sleep problems in people recovering from alcohol dependence, magnesium showed benefit only in single small, mostly open-label studies.Pharmacological treatment of insomnia in alcohol recovery: a systematic review.
- A review of 12 randomized trials in adults found inconsistent results for oral magnesium on sleep, with possible modest benefits for some self-reported outcomes and low to very low certainty, so it is not supported as a routine insomnia treatment.Magnesium Supplementation for Sleep in Adults: A Systematic Review of Randomized Controlled Trials.
- In 290 people with diabetes and insomnia who finished the trial, 2 months of magnesium, potassium or both reduced insomnia severity and shifted sleep hormones (melatonin and cortisol) compared with placebo.Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
- In 216 people with nighttime leg cramps (175 finished), 226 mg of magnesium oxide monohydrate at bedtime for 60 days improved sleep quality more than placebo and cut cramps more.A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate …
- In 171 healthy adults with mild insomnia, a magnesium-containing multi-ingredient blend for 2 weeks did not improve sleep quality more than placebo, as both groups improved.Exploring the Effect of Lactium™ and Zizyphus Complex on Sleep Quality: A Double-Blind, Randomized Placebo-Controlled Tr…
- In 128 perimenopausal and postmenopausal women with sleep disturbance, a multi-ingredient supplement containing magnesium for 3 weeks improved sleep scores (90.9% responders vs 45.2% on placebo) and added about 41 minutes of sleep.Nonsedating neurotransmitter-modulating supplement for nonvasomotor sleep disturbance in menopause.
- In 121 older adults with frequent leg cramps, magnesium for 4 weeks did not reduce cramp frequency compared with placebo, and sleep-related benefit was only reported for compression stockings.Secondary prevention of leg cramps using compression stockings or magnesium supplements: a three-arm randomized clinical…
- In 120 patients having laparoscopic gallbladder surgery, intravenous magnesium sulfate was associated with better sleep quality than saline placebo during recovery, alongside lower pain and a med use.Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
- In a placebo-controlled trial of 103 healthy active adults, an evening blend containing 2 grams of magnesium L-threonate (145 mg elemental magnesium), L-theanine and apigenin for 2 weeks did not show a sleep improvement reported in the abstract; the sleep gains were seen with the morning adaptogen product instead.Modulating stress and sleep through a multi-compound dietary supplement: a randomized, double-blind, placebo-controlled …
- In 100 adults with poor sleep, 320 mg of magnesium citrate daily for 7 weeks did not improve sleep more than placebo, since sleep quality improved in both groups; magnesium lowered inflammation marker CRP only in those with high baseline levels.Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 ye…
- In 100 chronically stressed adults, a multi-ingredient product containing magnesium improved daytime sleepiness scores over 4 weeks compared with placebo; the magnesium effect alone is unknown.Effect of a Combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-Theanine) on Chronically Stressed Healthy I…
- In 100 adults with poor sleep, 2 g daily of magnesium L-threonate for 6 weeks improved self-reported sleep-related impairment more than placebo, but there were no group differences in objectively measured sleep.The effects of magnesium L-threonate (Magtein®) on cognitive performance and sleep quality in adults: a randomised, doub…
- In a placebo-controlled trial of 94 older adults taking magnesium oxide at bedtime for 4 weeks, sleep quality did not differ from placebo.Effect of Magnesium Oxide Supplementation on Nocturnal Leg Cramps: A Randomized Clinical Trial.
- In 89 menopausal women with sleep or mood problems, a daily tablet containing 50 mg of magnesium and Magnolia bark extract reduced insomnia and other symptoms more than calcium plus vitamin D over 24 weeks.Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause.
- In a randomized placebo-controlled crossover trial of 89 women and men with fibromyalgia, a supplement combining coenzyme Q10, tryptophan and magnesium over three months improved sleep quality, though the dose of magnesium was not stated and the combination cannot be attributed to magnesium alone.Effects of Coenzyme Q10, Tryptophan, and Magnesium Supplementation on Fatigue in Patients with Fibromyalgia - A Randomiz…
- In 80 patients having lumbar spine surgery, intraoperative magnesium sulphate was linked to post-operative insomnia and pain, but the abstract does not state whether it made sleep better or worse.Effect of intra-operative Magnesium sulphate on the occurrence of post-operative delirium and insomnia in patients under…
- Adults aged 35 to 55 with self-reported sleep problems who took 1 gram a day of magnesium L-threonate for 21 days kept better sleep quality and daytime functioning than those on placebo, whose scores declined.Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A rand…
- In 75 adults with restless legs syndrome, 250 mg of magnesium oxide daily improved sleep quality and symptom severity after two months compared with placebo, though no difference appeared in the first month.Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized cont…
- In 50 patients having open gallbladder surgery, intravenous magnesium sulfate gave better sleep quality on the first night after surgery than saline, without reducing morphine needs.Effect of intraoperative magnesium infusion on perioperative analgesia in open cholecystectomy.
- In 50 patients having scoliosis surgery, intravenous magnesium given with ketamine improved sleep quality on the first night after surgery compared with ketamine and saline, alongside lower morphine use.Ketamine and magnesium association reduces morphine consumption after scoliosis surgery: prospective randomised double-b…
- In 46 older adults with insomnia, 500 mg of magnesium daily for 8 weeks improved sleep time, sleep efficiency, and time to fall asleep compared with placebo.The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial…
- In 43 adults with trouble falling asleep, an evening blend containing 12.6 mg of magnesium plus mulberry leaf and tryptophan shortened time to fall asleep by about 3 to 4 minutes and improved next-morning sleep quality over 14 days compared with a control, though magnesium was a minor part of the blend.Mulberry leaf extract combined with tryptophan improves sleep and post wake mood in adults with sleep complaints - A ran…
- In 42 adults with nocturnal leg cramps, 900 mg of magnesium citrate twice daily for one month did not outperform placebo for cramps or the sleep disruption they caused.Magnesium for the treatment of nocturnal leg cramps: a crossover randomized trial.
- In 42 people having abdominal hysterectomy, intravenous magnesium sulfate before and after surgery led to better sleep quality in the postoperative period than saline, with insomnia rising in the saline group but not the magnesium group.Role of magnesium sulfate in postoperative analgesia.
- In a placebo-controlled trial of 40 exercise-trained adults, a recovery drink containing 420 mg magnesium citrate along with cannabinoids and amino acids, taken twice daily for 3.5 days, did not change sleep quality compared with placebo.A randomized, double-blind, placebo-controlled, repeated-dose pilot study of the safety, tolerability, and preliminary e…
- In 40 adults with depression, 250 milligrams of daily magnesium added to a med for 6 weeks produced greater improvement than a med alone, with the insomnia domain among the areas that improved most.Read the study on PubMed (41916937) →
- In 35 people with sleep problems, a bedtime coffee pod with 200 mg magnesium and 1.9 mg melatonin for 4 weeks improved sleep quality more than placebo, though scores still indicated poor sleep on average.The effects of melatonin and magnesium in a novel supplement delivery system on sleep scores, body composition and metab…
- In 35 post-menopausal women with osteoporosis taking zoledronate, 200 mg of magnesium daily for 3 months did not change sleep quality or other measured outcomes compared with baseline.Quantitative sensory testing of pain in osteoporosis: a pilot randomized clinical trial with magnesium supplementation.
- In 24 people after major lumbar spine surgery, a single intravenous magnesium sulphate infusion at the start of anaesthesia was followed by better sleep on the first night than saline.Effect of intra-operative magnesium sulphate on pain relief and patient comfort after major lumbar orthopaedic surgery.
- In 22 women with fibromyalgia, a Mediterranean diet enriched with 60 milligrams of magnesium and 60 milligrams of tryptophan for 16 weeks did not improve sleep quality compared with the standard diet.Psychological and Sleep Effects of Tryptophan and Magnesium-Enriched Mediterranean Diet in Women with Fibromyalgia.
- In 20 people with nerve pain, a single 3 g intravenous magnesium infusion with ketamine gave no significant improvement in sleep compared with placebo over 5 weeks.Ketamine and Magnesium for Refractory Neuropathic Pain: A Randomized, Double-blind, Crossover Trial.
- In 16 young adults, a blend that included magnesium with other ingredients taken for 3 days shortened time to fall asleep, lengthened total sleep and improved sleep efficiency compared with placebo, so the effect cannot be attributed to magnesium alone.Nutritional Modulation of Sleep Latency, Duration, and Efficiency: A Randomized, Repeated-Measures, Double-Blind Decepti…
- In 16 trained men given two nights of partial sleep loss, a zinc magnesium aspartate supplement did not improve sleep quality compared with placebo or no pill.Effects of Supplementing Zinc Magnesium Aspartate on Sleep Quality and Submaximal Weightlifting Performance, following T…
- In a randomized bowel-prep comparison for colonoscopy, a sodium picosulfate and magnesium oxide mix was tolerated better than a mannitol mix, and sleep problems were reported more often with the mannitol mix; the abstract does not report any sleep benefit from magnesium.Comparative study between manitol and sodium picosulfate with magnesium oxide solutions in the preparation for colonosco…
- In people with fibromyalgia, 100 mg of magnesium chloride daily for 1 month did not produce significant differences from placebo in sleep, though it did reduce stress in a subgroup and pain.Short-Term Magnesium Therapy Alleviates Moderate Stress in Patients with Fibromyalgia: A Randomized Double-Blind Clinica…
- In adults with temporomandibular disorders, a nightly multi-ingredient tablet containing magnesium for 40 days produced greater improvement in pain, headache and sleep or mood problems than controls, though the magnesium amount and participant numbers were not stated in the abstract.The role of nutraceuticals in the management of temporomandibular disorders.
- In a randomized bowel preparation trial, magnesium citrate caused more sleep interruption than Picolax, so it was worse for sleep in that setting.A comparative trial of magnesium citrate (Citramag) and Picolax for barium enema bowel preparation.
- In 100 people preparing for a colon scan, a prep using diet, magnesium citrate and barium caused less sleep disturbance than a standard prep with polyethylene glycol, though magnesium was only one part of this bowel prep.Dietary fecal tagging as a cleansing method before CT colonography: initial results polyp detection and patient acceptan…
- In 60 patients before heart surgery, 500 mg of magnesium oxide daily for five days improved sleep quality scores compared with routine care alone.Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart sur…
- In 43 long-term care residents with chronic trouble sleeping, a nightly supplement containing 225 mg magnesium plus melatonin and zinc for 8 weeks improved sleep quality more than placebo, though the magnesium effect cannot be separated from the other ingredients.The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in Italy: a double…
- In an open-label pilot of 12 adults with restless legs syndrome, 200 milligrams of magnesium citrate daily for 8 weeks significantly reduced symptom scores and improved quality of life, though without a placebo group the results are preliminary.Magnesium citrate monotherapy improves restless legs syndrome symptoms and multiple suggested immobilization test scores…
- In 10 adults with restless legs or leg-movement insomnia, an evening magnesium dose of 12.4 mmol for 4 to 6 weeks reduced leg-movement arousals and improved sleep efficiency, with 7 of 10 reporting better sleep, in an open study without a placebo group.Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study.
- In a large national survey of U.S. adults, those who slept under 7 hours a night had lower usual magnesium intake from food and supplements than those who slept longer, though this study cannot show that low magnesium causes short sleep.Micronutrient Inadequacy in Short Sleep: Analysis of the NHANES 2005-2016.
- In a large long-term study of young adults, those with the highest magnesium intake were less likely to report short sleep under 7 hours; the link to sleep quality was borderline.Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
- In 810 children aged 5 to 12 referred for attention problems, 12 weeks of a fatty acid, magnesium and zinc supplement was followed by fewer problems falling asleep, though this uncontrolled cohort cannot separate magnesium's effect from the other ingredients.Supplementation of polyunsaturated fatty acids, magnesium and zinc in children seeking medical advice for attention-defi…
- In 112 young Japanese women, a later preferred midpoint of sleep and an evening-type body clock were linked to lower magnesium intake from the diet, though this study cannot show that magnesium affects sleep timing.Dietary intake is associated with human chronotype as assessed by both morningness-eveningness score and preferred midpo…
- In 34 younger adults tracking their daily food intake and sleep with a wrist monitor, higher magnesium intake was only linked to a non-significant trend toward less disrupted sleep (P=.09), so no clear sleep benefit was shown.Higher daytime intake of fruits and vegetables predicts less disrupted nighttime sleep in younger adults.
- In eight people with nerve pain, weekly intravenous magnesium lowered pain in four; some reported good sleep afterward, but sleep was not formally measured.[Relief of neuropathic pain with intravenous magnesium].
Review Totals and Summary
Members Only24,483 reviews · 81% positive
This Nature Made Magnesium Glycinate 200 mg product has received about 23769 ratings across various stores, with 69% of them being 4 or 5 stars. Overall, customers find it effective for several health benefits, though some common complaints exist regarding the capsule size and packaging. **What buyers say it did for them:** Many customers report significant benefits from taking these capsules. A frequent theme is improved sleep and evening relaxation, with users noting it helps them "fall asleep and stay asleep without a hangover" and "helps me to relax in the evening." It is also praised for being "Great for your stomach," with many finding it gentle and not causing upset, even when taken at night. Some reviewers highlight its effectiveness in preventing and relieving leg cramps, with one stating it "helps with my leg cramps." Other reported benefits include maintaining regularity, recuperating from muscle soreness, and even improving overall mood, with one user noting, "My overall mood has been much better." **Complaints:** The most common complaint revolves around the size of the capsules, with many finding them "Too big to swallow" and wishing the size was disclosed before purchase. Another recurring issue is a discrepancy regarding the USP verification label; some customers received bottles without the label despite website images showing it, leading to concerns about "false advertisement." Less frequent but notable complaints include receiving bottles with "packaging was damaged" or containing "a lot of powder in the bottle." One long-time user reported a possible reformulation, experiencing a "taste and smell like it was musty" and subsequent digestive upset, which was "very different than my past experiences." **Taste, smell, pill size, and form:** The product is sold as capsules. While some reviewers find the "capsules are tasteless" and have "no noticeable odour," others, as noted in store summaries, describe the taste as mild or pleasant, but some found it bitter or overpowering. One reviewer specifically mentioned a "musty or mildew like" taste and smell. As for size, it's a mixed bag: many find the pills "huge" and difficult to swallow, while others state they are "easy to swallow." It's worth noting that some reviews mentioned a gummy version of the product, but this summary focuses solely on the capsules. **Value for money:** Many customers consider this product to offer good value. Reviewers frequently describe it as a "Good Price for a good quality" magnesium glycinate, and store summaries confirm that the price is reasonable for a quality product. **Who it seems to suit and who it did not:** This magnesium glycinate appears to suit individuals seeking help with sleep, evening relaxation, leg cramps, and digestive regularity, especially those who prefer a supplement that is gentle on the stomach. It is particularly well-received by those who find the capsules easy to take despite their size. However, it may not be suitable for individuals who struggle with swallowing large pills or those who are sensitive to potential taste or smell variations. Customers concerned about packaging accuracy, such as the USP label, might also find these issues problematic.
Biohacker Summary
Members Only6 of 10 recommend it
Most of the panel backs magnesium: five recommend it, four say they use it, and one warns about labels, while a couple stay neutral. The main reason is sleep, with several taking it in the evening, one suggesting 90 minutes to 2 hours before bed, and others also citing stress, muscle recovery, blood pressure and bone health. Forms vary: glycinate is favored by three of them for sleep and calm, while threonate is the most common choice among those who give a dose, usually 400 mg before bed. Daily amounts mentioned run from 300 mg at bedtime up to 400 to 600 mg a day, and one person aims for about a gram, with some pairing it with sodium and potassium in electrolyte drinks. The one caution is that some labels list the weight of the whole compound rather than the actual magnesium, which can make the dose look much larger, and one panelist adds that evidence for sleep benefits is mixed.
See all 10 biohackers →Hide the biohackers
Dr. Rhonda Patrick · Magnesium · recommends
- Explains that magnesium helps the body activate and metabolize vitamin D, and that magnesium intake has been associated with lower odds of vitamin D deficiency and insufficiency.
- Mentions that getting too little magnesium may play a role in declining testosterone levels.
- Recommends getting enough magnesium, around 300–400 mg daily from diet and supplements, as it is an essential cofactor for vitamin D metabolism. Magnesium glycinate is a good form.
- Mentions magnesium as one of the micronutrients found in multivitamins that people often don't get enough of from their diets.
- Explains that magnesium helps control blood pressure by boosting the production of substances that relax blood vessels and improve cardiovascular health, citing a meta-analysis that found magnesium supplementation at an average dose of 368 mg per day notably lowers both systolic and diastolic blood pressure.
- Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
- Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
- Mentions magnesium as an important nutrient component for testosterone.
- Warns that some supplement companies mislead consumers by listing the total compound weight of magnesium citrate as the elemental magnesium dose, when the actual elemental magnesium content is much lower, potentially around 44-66 milligrams.
- States there is not yet strong, consistent evidence that magnesium supplementation reliably improves sleep, noting that while some meta-analyses suggest it can improve sleep quality scores, sleep efficiency, and sleep duration, individual studies are inconsistent and several have found no meaningful effect.
Dr. Eric Berg · Magnesium · recommends
- Recommends Magnesium glycinate, noting its high absorption rate compared to magnesium oxide, and its support for energy, sleep, muscle relaxation, and vitamin D function.
- Dr. Berg states that when nutrients like magnesium are too low, fatigue and weakness can follow.
- Recommends focusing on magnesium to support stronger bones if a neck hump is associated with osteoporosis.
- Explains that leg and calf cramps are most often caused by low magnesium, with leafy greens being a top source.
- States that magnesium is a cofactor that allows B1 to work more efficiently.
- States that magnesium is the most important mineral for energy production, as one cannot make energy without it.
- Magnesium is involved in 300 to 600 enzyme reactions, acts as a biological brake pedal, is the master controller over calcium, and is involved in making ATP, the energy currency of the body. It takes energy to go to sleep, and magnesium is required for relaxation and good sleep. Magnesium also helps balance cortisol levels and calm you.
- Dr. Eric Berg states that magnesium supports energy, muscle function, and sleep, and that most of it is stored inside cells, making deficiencies harder to detect with a standard blood test.
- Notes that magnesium could also be a factor in preventing muscle cramps.
- Recommends magnesium, specifically magnesium glycinate, stating it is key for D3 and K2 to work and is probably more important than calcium for building bone.
Thomas DeLauer · Magnesium · recommends
- Recommends taking magnesium glycinate and threonate at night to act as a brake on the nervous system, block excitatory signaling, help wind down, and support serotonin and melatonin production for better sleep.
- Mentions that magnesium glycinate also helps a lot with sleep.
- Mentions that restless leg syndrome is often treated with magnesium, but states that the sensation is actually coming from three other issues.
- Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
- Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
- Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
- Recommends magnesium, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
- Notes that modern agricultural practices have led to soils depleted of trace minerals like magnesium, resulting in widespread magnesium deficiency.
- Recommends taking some magnesium glycinate tonight to help calm down and sleep.
- Mentions that magnesium in pumpkin seeds relaxes bronchial smooth muscle.
Andrew Huberman · Magnesium · recommends
- Notes that Les Spellman's team includes 'Magnesium timed right' as part of their game plan to optimize recovery in unfavorable conditions.
- Discusses Magnesium Threonate as a tool for falling asleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Confirms that magnesium is absolutely important for cognitive function, noting studies show those with lower magnesium intakes tend to perform less well on cognitive function tests, and it's related to brain changes over time and dementia risk.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- He takes 400 mg of Magnesium L-Threonate from Double Wood before bed for sleep.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium L-threonate before bed for sleep.
Dr. Mark Hyman · Magnesium · recommends
- Recommends magnesium breakthrough advanced ten from Biooptimizers, which is their most complete magnesium formula with 10 bioavailable forms and 550 milligrams of elemental magnesium, designed to support restful restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
- Explains that a lack of magnesium can cause muscles and nerves to malfunction, resulting in muscle weakness, twitching, and cramps.
- Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
- Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
- Recommends magnesium as a basic supplement during detoxification to support pathways, help with constipation, and provide electrolytes.
- Recommends Magnesium Breakthrough Advanced 10 from Biooptimizers, which contains 10 bioavailable forms and 550 mg of elemental magnesium, to support restful sleep, restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Has recommended magnesium breakthrough from bioptimizers for years and now uses Magnesium Breakthrough Advanced 10 as part of his evening routine, especially during periods of travel, training, and higher stress, to support sleep, muscle recovery, and metabolic health.
- Recommends correcting nutrient deficiencies with magnesium.
- Recommends Magnesium Breakthrough Advance 10 from BiOptimizers, which has 10 bioavailable forms of magnesium and more elemental magnesium, as part of his evening routine for sleep, muscle recovery, and metabolic health.
Dave Asprey · Magnesium · uses
- Looks at magnesium alongside protein to keep muscle for the long run.
- Suggests adding magnesium to help keep potassium in the system longer, as they work hand in hand.
- Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
- Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
- States that magnesium can affect how the body responds to a supplement.
- Recommends fixing sleep with 300mg of Magnesium 101 before bed if diet and exercise aren't melting stubborn belly fat.
- Dave Asprey says his daily routine includes magnesium as part of a carefully developed combination for longevity.
- Recommends magnesium glycinate for sleep, stating that trials show it helps people fall asleep about 17 minutes faster and that he finds it incredibly effective.
- Mentions magnesium glycinate as one of the five gut-friendly, extensively researched ingredients in Kill Switch that helps with natural sleep.
- Dave Asprey recommends Magnesium Glycinate for sleep, noting human studies show it helps people fall asleep faster, is safe, and works on a fundamental aspect of health, unlike magnesium oxide which acts as a laxative.
Ben Greenfield · Magnesium · uses
- Uses magnesium during surgery because it is neuroprotective.
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Mentions magnesium as part of a bare-minimum protocol.
- Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
- Recommends supplementing with magnesium threonate if one is low in magnesium, as it crosses the blood-brain barrier and is demonstrated to increase hippocampus plasticity, theoretically making one smarter and improving memories.
- Uses Magnesium Breakthrough from BIOptimizers as part of their daily stack, taking four capsules in the evening to support relaxation, recovery, and a good night of sleep.
- Recommends Celtic Sea Salt's new electrolyte drink "Hydrate" for replacing electrolytes and trace minerals lost through sweat, noting it contains 70 naturally occurring trace minerals, plus magnesium, taurine, and potassium.
- Had heart palpitations when he was really overdoing magnesium, not knowing what he was taking.
- Recommends taking magnesium as a co-factor to increase vitamin D absorption.
- Notes a new study indicating that magnesium is a core dietary antioxidant closely associated with a reduced risk of accelerated biological aging.
Siim Land · Magnesium · recommends
- States that Magnesium can be a useful addition for some people for sleep.
- Recommends magnesium for sleep, especially deep sleep, and suggests trying better types like Threonate, Biscinate, or Torate, referencing a study where magnesium supplementation improved deep sleep.
- Recommends Magnesium for blood pressure, migraines and deficiency, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Magnesium as one of 15 supplements backed by human studies.
- States that magnesium is a fundamental mineral governing over 600 enzymes and metabolic reactions, and recommends that most people need at least 400-500 mg/d for health, with some needing up to 600 mg/d.
- Lists seafood and pumpkin seeds as sources of Magnesium.
- Thinks magnesium has some of the strongest evidence and is worth considering.
- Recommends taking magnesium, specifically glycinate and threonate forms, 1 to 2 hours before bed for sleep benefits, noting that glycinate promotes relaxation and threonate crosses the blood-brain barrier for sleep quality and cognitive function.
- Notes that Boron reduces calcium/magnesium loss.
- Notes that magnesium is important for activating thiamine into its more biologically active form, and a magnesium deficiency can impair blood sugar regulation even with adequate thiamine intake.
Bryan Johnson · Magnesium · uses
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- He takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium L-threonate before bed for sleep.
- He takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium threonate before bed for sleep.
Peter Attia · Magnesium · neutral
- Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
- Recommends magnesium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 300 to 500 milligrams as a minimum, and personally aims for about a gram of supplemental magnesium.
- Recommends magnesium for optimizing bone mineral density, suggesting a daily intake of 300 to 500 milligrams as a minimum, but personally aims for about a gram.
- Takes a hardline view that most people do not have adequate or optimal levels of magnesium, and suboptimal levels will impede the metabolism of vitamin D because magnesium is a cofactor in its enzymatic conversion.
- Takes a hardline view that most people do not have adequate or optimal levels of magnesium, and suboptimal levels will impede vitamin D metabolism because magnesium is a co-factor in the enzymatic conversion of vitamin D.
- Takes magnesium as a straightforward supplement.
- Mentions that magnesium intake is often super low and impactful on testosterone levels.
- Discusses the important roles of magnesium in the body, how to determine if one might be deficient, the prevalence of magnesium deficiency, and its potential cognitive benefits.
RAL Summary
Members OnlyTier 4 for Sleep
The rules read the magnesium evidence as showing no effect, but more studies found benefit than not and a pooled analysis found modestly faster sleep onset, so the evidence is mixed rather than negative. So it is graded Tier 4, as the studies disagree.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 18 of the 53 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Nervous system, Musculoskeletal system
Combine with: To enhance the sleep-promoting effects of Magnesium Glycinate, consider combining it with supplements like Melatonin, which helps regulate sleep-wake cycles, or L-Theanine, known for its calming properties without causing drowsiness. Valerian root or Chamomile can also be synergistic, offering additional natural relaxation and sleep support.
Possible side effects: No major side effects reported in the studies given. Buyer feedback summaries mention large capsules that are hard to swallow and occasional digestive upset.
Supplement Facts
Magnesium 200 mg
| Magnesium (as Magnesium Bisglycinate) | 200 mg | 48% |
Other ingredients: Hypromellose, Magnesium Stearate, Cellulose Gel, Silicon Dioxide.
Directions: SUGGESTED USE: Adults, take 2 capsules daily with water and a meal.
Label source: Naturemade · Report a label change
Sizes and barcodes: 60 Capsule(s), UPC 0 31604 04313 1 (on market)
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Our articles on this subject
- Magnesium Glycinate vs Citrate: What the Studies ShowArticle · Oct 30, 2026
- Melatonin vs Magnesium for Sleep: What the Studies ShowArticle · Nov 3, 2026
Graded October 26, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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