Nature Made Triple-Action Biotic Gummies Review
Tier ⓘ
Tier 4 · Rank 26
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 26 within Tier 4 for Blood Sugar; 71 of 78 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
15 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
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Study, Trial or Testing Result Summary
Members Only91 human studies · 54 improved
91 human studies54 improved20 no effect28,649 people studied
The main ingredient with research behind it is soluble fiber, at 3 grams a day. Several pooled analyses of human trials in people with type 2 diabetes found that soluble fiber lowered long-term blood sugar, fasting glucose, insulin and insulin resistance [1]. Thick, gel-forming fiber at about 13 grams a day lowered long-term blood sugar by 0.58 points [2]. Similar benefits appeared across 45 trials of fermentable fiber [3] and in another pooled analysis, where fasting glucose benefits were seen above 8.3 grams a day [4]. In overweight adults, fiber supplements modestly lowered fasting glucose [5]. Note that most of these studies used more fiber than the 3 grams in this product, with 7.6 to 8.3 grams a day suggested [1]. The two probiotics have very thin evidence. The only study of the same species as Immuno-LP20 tested a different strain in yoghurt and lowered blood sugar only in overweight people [6]. The only study near Bacillus coagulans Unique IS-2 used a different strain mixed with other ingredients, lowering insulin but not fasting blood sugar [7]. The doses of both probiotics in the studies are unclear. Animal and cell studies are never counted.
See all 91 studies →Hide the studies
- Across 45 trials in 1,995 people with type 2 diabetes, eating more fermentable fiber carbohydrates lowered long-term blood sugar (HbA1c) by about 0.44 percentage points, fasting glucose, cholesterol, triglycerides, body mass index and systolic blood pressure compared with lower intake.Higher intake of microbiota-accessible carbohydrates and improved cardiometabolic risk factors: a meta-analysis and umbr…
- Across 29 trials in 1,517 adults with type 2 diabetes, soluble fiber supplements lowered long-term blood sugar (HbA1c) by 0.63 percentage points, fasting glucose, insulin, insulin resistance and after-meal glucose compared with control diets, with 7.6-8.3 g per day suggested.Effects of soluble fiber supplementation on glycemic control in adults with type 2 diabetes mellitus: A systematic revie…
- Across 28 trial comparisons in 1,394 people with type 2 diabetes, viscous fiber at about 13.1 g per day lowered HbA1c by 0.58 percentage points, fasting glucose by 0.82 mmol/L and insulin resistance compared with control.Should Viscous Fiber Supplements Be Considered in Diabetes Control? Results From a Systematic Review and Meta-analysis o…
- Across 17 trials in 916 people with high cholesterol, beta-glucan lowered total and LDL cholesterol but did not change blood glucose, triglycerides or HDL cholesterol.Quantitative assessment of the effects of beta-glucan consumption on serum lipid profile and glucose level in hyperchole…
- Across 12 trials of 2 to 17 weeks in 609 adults with overweight or obesity, soluble fiber supplements lowered fasting glucose by 0.17 mmol/L, fasting insulin, body weight by 2.5 kg and body mass index compared with placebo.Effects of isolated soluble fiber supplementation on body weight, glycemia, and insulinemia in adults with overweight an…
- Across 11 trials of 8 to 24 weeks in 605 people with type 2 diabetes, high-fiber diets or soluble fiber supplements (up to 15 g per day) lowered HbA1c by 0.55 percentage points and fasting glucose by about 10 mg/dL.Fiber intake and glycemic control in patients with type 2 diabetes mellitus: a systematic review with meta-analysis of r…
- In 37 pooled placebo-controlled trials in healthy adults, up to 10 g of resistant maltodextrin reduced the blood sugar rise after carbohydrate foods, by about 20% in drinks and about 10% when added to foods at 6 g.Interventions to lower the glycemic response to carbohydrate foods with a low-viscosity fiber (resistant maltodextrin): …
- Across 28 trials lasting 2 to 12 weeks, at least 3 g per day of oat beta-glucan lowered LDL cholesterol by 0.25 mmol/L and total cholesterol by 0.30 mmol/L compared with control, without changing HDL cholesterol or triglycerides.Cholesterol-lowering effects of oat β-glucan: a meta-analysis of randomized controlled trials.
- Across 31 randomized trials, foods fortified with fiber lowered body weight, fat mass, total and LDL cholesterol, triglycerides, fasting blood sugar and HbA1c, and soluble fiber specifically lowered triglycerides and insulin.Impact of fiber-fortified food consumption on anthropometric measurements and cardiometabolic outcomes: A systematic rev…
- In 8 pooled trials of pregnant women with gestational diabetes, added fiber lowered fasting and after-meal blood sugar, HbA1c, and cholesterol, though insoluble fiber worked better than soluble fiber for fasting glucose.Effects of Additional Dietary Fiber Supplements on Pregnant Women with Gestational Diabetes: A Systematic Review and Met…
- In a pooled analysis of randomized trials in people with type 2 diabetes, viscous soluble fiber lowered long-term blood sugar (HbA1c), fasting blood sugar, total cholesterol and LDL cholesterol compared with controls, with HbA1c benefits seen after more than 6 weeks and fasting glucose benefits above 8.3 g per day.Effect of viscous soluble dietary fiber on glucose and lipid metabolism in patients with type 2 diabetes mellitus: a sys…
- Across 38 trials in people with type 2 diabetes, soluble fiber lowered triglycerides, LDL and total cholesterol and raised HDL cholesterol.Effect of soluble fiber supplementation on lipid parameters in subjects with type 2 diabetes: A systematic review and me…
- Oat intake lowered total and LDL cholesterol consistently, while triglyceride and HDL cholesterol results were mixed, with triglyceride reductions reported in only 6 of 17 studies.Effect of Oat (Avena sativa L.) Consumption on Lipid Profile With Focus on Triglycerides and High-density Lipoprotein Ch…
- In 41 crossover trials of single meals, soluble fiber did not clearly change blood sugar in normal-weight people and had mixed effects on insulin, while resistant starch looked more effective.Acute Effects of Dietary Fiber in Starchy Foods on Glycemic and Insulinemic Responses: A Systematic Review of Randomized…
- In a 24-week randomized trial of 621 patients, a diet higher in soluble fiber, fruit and vegetables, plus yogic exercise, lowered fasting blood glucose by 19.5% compared with the control diet group.Effects of diet and lifestyle changes on atherosclerotic risk factors after 24 weeks on the Indian Diet Heart Study.
- In 376 pregnant women at risk of metabolic syndrome, daily soluble fiber supplements until delivery were safe and reduced the need for constipation medication, while low fiber intake was linked to higher gestational diabetes risk.Effects of dietary fiber on maternal health in pregnant women with metabolic syndrome risk: a randomized controlled tria…
- In 242 adults with high LDL cholesterol, two daily servings of soymilk enriched with plant sterols and fiber for 8 weeks lowered LDL cholesterol 5.5 mg/dL more than plain soymilk, but fasting blood sugar did not differ.A randomized study comparing plant sterol- and soluble fiber-enriched soymilk with plain soymilk in adults with elevated…
- In two placebo-controlled trials with 240 middle-aged adults in total, daily yoghurt with this probiotic for four weeks lowered cholesterol in both groups, but blood sugar fell only in overweight people taking the probiotic yoghurt, and the LDL cholesterol difference from placebo appeared only in people with normal weight.Impact of Lactiplantibacillus plantarum Inducia on metabolic and antioxidative response in cholesterol and BMI variable …
- In 194 adults at risk of type 2 diabetes, eating 6 grams a day of beta-glucan oat bread for 16 weeks did not improve HbA1c, fasting glucose, insulin or LDL cholesterol compared with whole-grain wheat bread.Effectiveness of regular oat β-glucan-enriched bread compared with whole-grain wheat bread on long-term glycemic control…
- In 117 adults with type 2 diabetes, taking 10 or 20 grams of extra soluble fiber daily for one month improved blood sugar, insulin resistance, and triglycerides compared with a control group.Therapeutic effects of soluble dietary fiber consumption on type 2 diabetes mellitus.
- In a 24-week double-blind trial of 104 adults with type 2 diabetes, a daily blend of 10 g viscous fiber, chia seeds and ginseng lowered HbA1c by 0.27 percentage points more than a fiber-matched control, with greater benefit in those starting above 7%.Co-administration of viscous fiber, Salba-chia and ginseng on glycemic management in type 2 diabetes: a double-blind ran…
- In a 5-week randomized trial of 98 high-risk pregnant women, daily soluble fiber supplements improved blood sugar levels during a glucose test and reduced weight gain, although gestational diabetes rates did not differ significantly.Dietary fiber supplementation mitigates gestational diabetes risk and preterm birth via gut microbiota modulation: a ran…
- In 88 adults treated for high blood pressure, 12 weeks of whole-grain oat cereals let 73% stop or halve their meds versus 42% on refined wheat cereals, and also lowered cholesterol and blood glucose compared with controls.Do whole-grain oat cereals reduce the need for antihypertensive medications and improve blood pressure control?
- In 77 adults with metabolic syndrome, eating 2 ounces of almonds daily for 12 weeks lowered total and LDL cholesterol versus crackers, but blood sugar, insulin and body-wide inflammation markers did not change.Beneficial changes in total cholesterol, LDL-C, biomarkers of intestinal inflammation, and vitamin E status in adults wi…
- In 75 healthy adults taking 6 grams a day of alpha-cyclodextrin for 12 to 14 weeks, small LDL particles fell 10 percent and fasting glucose and insulin resistance improved compared with placebo.Randomized double blind clinical trial on the effect of oral α-cyclodextrin on serum lipids.
- In 72 women with polycystic ovarian syndrome (60 finished), a daily synbiotic containing Bacillus coagulans GBI-30 for 12 weeks lowered insulin and insulin resistance more than placebo, but did not change fasting blood sugar or body measurements.Synbiotic-Containing Bacillus coagulans (GBI-30) and the Effects on Glycemic Control, Androgen Hormones and Anthropometr…
- In 60 adults with type 2 diabetes, a single meal with a viscous fiber bar produced lower blood sugar, insulin and C-peptide responses than two commercial bars, with more flatulence.Effect of a viscous fiber bar on postprandial glycemia in subjects with type 2 diabetes.
- In 54 healthy adults, 8.4 grams a day of arabinogalactan fiber for 6 months did not change blood cholesterol, blood fats, glucose or insulin compared with placebo.No long-term benefits of supplementation with arabinogalactan on serum lipids and glucose.
- In a 3-month trial of 53 healthy adults, a diet providing about 4 g of soluble fiber per day lowered fasting glucose by 12.3% and LDL cholesterol by 12.8% compared with baseline, while the lower-fiber group showed no significant change.Effect of soluble fiber intake in lipid and glucose levels in healthy subjects: a randomized clinical trial.
- In 53 overweight adults, 4 g of glucomannan daily for 8 weeks was well tolerated but did not change weight, lipids, or blood sugar compared with placebo.Safety and efficacy of glucomannan for weight loss in overweight and moderately obese adults.
- In 48 healthy adults, 40 g of acacia gum with breakfast increased fullness and reduced hunger, but total blood sugar response over time did not differ from control, with only one earlier time point lower.Acacia Gum Is Well Tolerated While Increasing Satiety and Lowering Peak Blood Glucose Response in Healthy Human Subjects…
- In 45 adults with type 2 diabetes, a breakfast with 6.6 grams of psyllium fiber lowered blood glucose and insulin after breakfast compared with a refined farina breakfast, but did not lower glucose after the later lunch (insulin was still lower).Effects of breakfast meal composition on second meal metabolic responses in adults with Type 2 diabetes mellitus.
- In a crossover trial of 41 adults, a lunch beverage with 20 g soluble fiber dextrin reduced hunger and raised fullness only after leaving the lab, and did not change appetite or food intake during the first 150 minutes; glucose responses were not improved.The effect of soluble fiber dextrin on postprandial appetite and subsequent food intake in healthy adults.
- In 40 adults with type 2 diabetes, 10.5 g of psyllium soluble fiber daily for 8 weeks improved fasting blood sugar (163 to 119 mg/dl), HbA1c (8.5 to 7.5%) and insulin resistance and lowered BMI compared with a regular diet.Soluble fibers from psyllium improve glycemic response and body weight among diabetes type 2 patients (randomized contro…
- In 37 adults with type 2 diabetes, 7 grams a day of psyllium added to a moderate carbohydrate diet for 2 weeks lowered fasting insulin and tumor necrosis factor-alpha and improved insulin sensitivity more than a lower carbohydrate diet with placebo powder.Short-Term Supplementation of a Moderate Carbohydrate Diet with Psyllium Reduces Fasting Plasma Insulin and Tumor Necros…
- In 31 adults with metabolic impairments, 12 weeks of biscuits made with brewer's spent grain fiber raised daily fiber intake, and only the fermented version raised HDL cholesterol, with no other significant changes.Impact of brewer's spent grain (BSG) and bio-transformed BSG biscuits on metabolic and gut health in adults with metabol…
- In 30 overweight men on a low-carbohydrate diet, adding 3 g per day of konjac fiber for 12 weeks lowered LDL cholesterol early on but gave no extra benefit over the diet alone compared with placebo.Effects of a carbohydrate-restricted diet with and without supplemental soluble fiber on plasma low-density lipoprotein …
- In obese adults, eating a cookie with 3 grams of inulin fiber daily for one month lowered total and LDL cholesterol compared with a control cookie, while insulin changes were not significant.[Randomized clinical trial with a inulin enriched cookie on risk cardiovascular factor in obese patients].
- In 30 adults with metabolic syndrome, 9 grams a day of resistant maltodextrin in tea for 12 weeks, compared with placebo tea, reduced waist size, belly fat, fasting blood sugar, insulin resistance and blood triglycerides.Improvement effect of resistant maltodextrin in humans with metabolic syndrome by continuous administration.
- In 25 healthy adults, mixing 4 grams of a viscous fiber blend into margarine lowered post-meal blood sugar, but baking it into bread had less effect and fiber capsules had no effect.Randomized clinical trial in healthy individuals on the effect of viscous fiber blend on glucose tolerance when incorpor…
- In 25 obese women on a controlled diet, 20 g per day of hydrolyzed guar fiber did not change blood sugar, insulin, leptin, or hunger ratings compared with placebo, though it raised a gut satiety hormone after meals.Effect of hydrolyzed guar fiber on fasting and postprandial satiety and satiety hormones: a double-blind, placebo-contro…
- In 22 young obese men, 500 mg of curcumin with fenugreek fiber for 12 weeks improved homocysteine and HDL cholesterol versus fiber alone, but blood sugar and blood pressure did not change, and the fiber itself was only the placebo.Influence of enhanced bioavailable curcumin on obesity-associated cardiovascular disease risk factors and arterial funct…
- In 22 healthy Chinese men, replacing half the carbohydrate in a meal with soluble corn fiber lowered both blood sugar and insulin responses compared with maltodextrin and glucose.The Role of Soluble Corn Fiber on Glycemic and Insulin Response.
- In 21 mildly high-cholesterol men, eating barley foods rich in soluble fiber for 4 weeks lowered total cholesterol by 6 percent and LDL cholesterol by 7 percent compared with wheat foods, with no change in blood sugar.Barley and wheat foods: influence on plasma cholesterol concentrations in hypercholesterolemic men.
- In 20 healthy adults, 15 or 30 grams of arabinogalactan fiber daily for three weeks each did not change blood sugar, insulin, or blood lipids compared with a control beverage.Effects of dietary arabinogalactan on gastrointestinal and blood parameters in healthy human subjects.
- In 20 intensive care patients with ongoing diarrhea, a tube feed with 2% guar gum for 4 days cut liquid stools and showed a trend toward lower blood sugar and cholesterol compared with a fiber-free feed.Control of diarrhea by fiber-enriched diet in ICU patients on enteral nutrition: a prospective randomized controlled tri…
- In 20 healthy adults, muffins with 4 to 12 g of mixed fiber raised blood sugar over 3 hours compared with a muffin without fiber, and the rise did not grow with higher doses.Glucose and insulin do not decrease in a dose-dependent manner after increasing doses of mixed fibers that are consumed …
- In 20 adults with prediabetes, a low-carbohydrate shake fortified with soluble fiber and isomaltulose caused a much smaller blood sugar rise over two hours than a standard shake, in a single serving test.Blood Glucose Response of a Low-Carbohydrate Oral Nutritional Supplement with Isomaltulose and Soluble Dietary Fiber in …
- In a single test meal, 10 grams of a viscous fiber blend in biscuits sharply reduced the blood sugar rise in both healthy adults and adults with type 2 diabetes compared with standard biscuits or white bread.Comparable postprandial glucose reductions with viscous fiber blend enriched biscuits in healthy subjects and patients w…
- In 19 overweight women, a meal preload high in soluble fiber lowered insulin and satiety hormone responses compared with no fiber, while a preload high in insoluble fiber raised triglycerides.Ratios of soluble and insoluble dietary fibers on satiety and energy intake in overweight pre- and postmenopausal women.
- In a crossover trial of 19 adults with type 2 diabetes, breakfasts with 5.4 g soluble fiber from foods or guar gum lowered the blood sugar rise after the meal compared with usual fiber, with both sources working about equally well.Plasma glucose and insulin responses after consumption of breakfasts with different sources of soluble fiber in type 2 d…
- In 18 men with mildly high cholesterol, 4 weeks of beta-glucan-enriched barley (about 8 to 12 g per day) did not significantly change cholesterol, fasting blood sugar or blood sugar after a glucose drink compared with the control.Randomized controlled crossover study of the effect of a highly beta-glucan-enriched barley on cardiovascular disease ri…
- In 18 men, 25 grams a day of L-rhamnose or lactulose for 4 weeks lowered blood triglycerides by about 10 percent, while glucose drinks raised them, though cholesterol was unchanged.L-rhamnose and lactulose decrease serum triacylglycerols and their rates of synthesis, but do not affect serum cholester…
- In 17 obese women at risk for insulin resistance, a single breakfast with 10 grams of oat beta-glucan reduced the early blood sugar peak and the insulin response, but did not change overall blood sugar over 2 hours.Glucose and insulin responses to whole grain breakfasts varying in soluble fiber, beta-glucan: a dose response study in …
- In 16 healthy adults, a single meal with 23 grams of psyllium fiber lowered the rises in blood sugar and insulin after eating compared with a low-fiber meal.A psyllium fiber-enriched meal strongly attenuates postprandial gastrointestinal peptide release in healthy young adults…
- In 14 adults with type 1 diabetes, taking about 4.6 grams a day of oat beta-glucan tablets before meals for two weeks raised peak glucose and daily glucose risk compared with placebo.Effect of Oral Pre-Meal Administration of Betaglucans on Glycaemic Control and Variability in Subjects with Type 1 Diabe…
- In 14 healthy adults, all spaghetti types lowered blood sugar peaks compared with glucose or white bread, but the high soluble fiber version did not differ from regular or whole wheat spaghetti.Effects of Spaghetti Differing in Soluble Fiber and Protein Content on Glycemic Responses in Humans: A Randomized Clinic…
- In 13 adults with type 2 diabetes, six weeks on a high-fiber diet with about 25 grams of soluble fiber a day lowered blood sugar, insulin levels and cholesterol compared with the standard fiber diet.Beneficial effects of high dietary fiber intake in patients with type 2 diabetes mellitus.
- In a crossover study of 12 healthy men, adding up to 6% soy-soluble polysaccharides to a 50 g glucose drink had no effect on blood sugar or insulin, while fiber added to dairy products lowered glucose responses only in comparison with glucose, not with the fiber-free dairy controls.Effects of soy-soluble fiber and flaxseed gum on the glycemic and insulinemic responses to glucose solutions and dairy p…
- In a small crossover trial of 12 healthy adults, a meal with 6 grams of a new soluble fiber powder lowered after-meal blood sugar more than pectin and boosted satiety, though the study did not report how long people took it.A New Dietary Fiber Can Enhance Satiety and Reduce Postprandial Blood Glucose in Healthy Adults: A Randomized Cross-Over…
- In 11 healthy adults, a diet with 20 grams of pea fiber daily for two weeks lowered fasting and after-meal triglycerides and after-meal insulin, with no change in cholesterol.Pea fiber lowers fasting and postprandial blood triglyceride concentrations in humans.
- In 11 healthy adults taking glucose with oat fiber drinks, the high-viscosity enzymatically processed oat beta-glucan lowered the blood sugar rise by about 17 to 20% compared with the other versions and control.Beta-glucan from two sources of oat concentrates affect postprandial glycemia in relation to the level of viscosity.
- In 10 fasting adults, a rice porridge with added carrageenan (a seaweed fiber) produced lower blood sugar after eating than the regular version, in a single-meal test.Carbohydrate availability of arroz caldo with lambda-carrageenan.
- In 10 people eating a single pasta meal, 1.7 g of psyllium fiber did not change stomach emptying or blood sugar, insulin or GLP-1 responses compared with plain pasta, though added fat did lower blood sugar.The effects of fiber enrichment of pasta and fat content on gastric emptying, GLP-1, glucose, and insulin responses to a…
- In 8 men with type 2 diabetes, eating about 9 g per day of soluble oat bran fiber in bread for 12 weeks lowered blood sugar and insulin after meals and lowered total and LDL cholesterol compared with white bread.Oat bran concentrate bread products improve long-term control of diabetes: a pilot study.
- In 7 men with type 2 diabetes, a meal with 5 grams of sodium alginate fiber slowed stomach emptying and produced lower rises in blood sugar and insulin than the same meal without it.A small dose of soluble alginate-fiber affects postprandial glycemia and gastric emptying in humans with diabetes.
- In a single exercise session, taking 14.5 grams of encapsulated guar gum fiber with a liquid sugar drink 45 minutes before cycling did not change blood sugar, insulin, or muscle glycogen use compared with the sugar drink alone.The effect of encapsulated soluble fiber on carohydrate metabolism during exercise.
- In adults with fatty liver disease (NASH) over 14 days, a diet plus a specialized food containing soluble fiber led to greater weight loss, lower cholesterol, and better insulin resistance than diet alone.[Modification of dietary patterns in patients with non-alcoholic steatohepatitis].
- In 48 adults with obesity and gut dysbiosis, 7 grams of soluble corn fiber three times daily with a low-calorie diet for 4 weeks lowered body fat, but cholesterol fell in both the fiber group and the diet-only group.[Evaluation of the effect of dietary soluble corn fiber on metabolic activity and colonic microbiota composition in pati…
- In 28 compliant overweight but not obese healthy adults, 2 months of alpha-cyclodextrin fiber lowered total and LDL cholesterol and body weight compared with the control phase, in a double-blind crossover trial.The beneficial effects of α-cyclodextrin on blood lipids and weight loss in healthy humans.
- In 38 overweight men with mildly high cholesterol, 6 g of oat beta-glucan in bread daily for 8 weeks lowered LDL cholesterol more than the diet without it (27.3% vs 16.8%) and also lowered fasting glucose and body weight.Oat-derived beta-glucan significantly improves HDLC and diminishes LDLC and non-HDL cholesterol in overweight individual…
- In 34 pregnant women with obesity, eating 280 grams of whole blueberries plus 12 grams of soluble fiber daily from early pregnancy to term was linked to lower blood glucose on a glucose challenge test, lower inflammation, and less weight gain than standard prenatal care alone.Dietary Blueberry and Soluble Fiber Supplementation Reduces Risk of Gestational Diabetes in Women with Obesity in a Rand…
- A single 5 gram dose of isomaltodextrin, a soluble fiber, blunted the blood sugar rise after sugary drinks in healthy people whose blood sugar was at the high end of normal.Attenuation of postprandial blood glucose in humans consuming isomaltodextrin: carbohydrate loading studies.
- In 11 healthy adults, oat biscuits with 4% inulin gave no added blood sugar benefit over plain oat biscuits, but raised insulin at some time points and reduced the hunger hormone ghrelin more.Evaluation of a high nutritional quality snack based on oat flakes and inulin: effects on postprandial glucose, insulin …
- In 10 overweight women, a meal of high soluble fiber barley reduced the rise in blood sugar and insulin more than a meal of oats or pure glucose.Comparison of hormone and glucose responses of overweight women to barley and oats.
- In 9 healthy adults, breads and porridges made from a high soluble fiber barley produced lower blood sugar and insulin rises than white bread, while common oat and barley products did not.Products based on a high fiber barley genotype, but not on common barley or oats, lower postprandial glucose and insulin…
- In 5 active men, a hot cereal with added water-soluble fiber produced lower peak blood sugar and insulin than liquid glucose before exercise.The effect of food matrix on carbohydrate utilization during moderate exercise.
- Adding xanthan gum, a soluble fiber, to a liquid enteral feed lowered blood sugar at 20 minutes after a single drink compared with the feed without it.The Addition of Xanthan Gum to Enteral Nutrition Suppresses Postprandial Glycemia in Humans.
- In 154 outpatients on a low-calorie diet, adding 40 grams a day of oat bran for 6 weeks did not improve metabolic syndrome, blood pressure or blood sugar more than the diet alone, and it lowered HDL cholesterol.Addition of oat bran reduces HDL-C and does not potentialize effect of a low-calorie diet on remission of metabolic synd…
- In 116 adults with high cholesterol on strong meds, adding about 6 g of soluble fiber daily for 12 weeks lowered blood glucose more than drugs alone.The role of soluble fiber intake in patients under highly effective lipid-lowering therapy.
- In 20 stable adults with diabetes, replacing usual bread and chapati with soluble fiber rich bread for 4 weeks improved fasting and after-meal blood sugar, and blood pressure, cholesterol and triglycerides also fell, with no stomach complaints; there was no control group.Effect of fiber bread on the management of diabetes mellitus.
- In an open-label crossover trial, eating a 200-kcal snack in the afternoon, including roasted sweet potato or fruit granola, reduced the rise in blood sugar after dinner compared with no snack, with the effect depending on snack timing.Effects of intake of four types of snack with different timings on postprandial glucose levels after dinner.
- In large cohort studies, higher blood levels of a gut-derived histidine byproduct were linked to higher heart disease risk, and dietary fiber, especially pectin, was a negative predictor of that byproduct, though the soluble fiber link was not statistically significant.Circulating imidazole propionate and coronary heart disease risk: interplay between histidine intake, fiber, and gut mic…
- In a cross-sectional study of about 6,000 French adults, higher total fiber intake was linked to lower odds of several heart risk factors, though soluble fiber was less effective than other fiber types.Dietary fiber intake and risk factors for cardiovascular disease in French adults.
- In 1,414 Japanese adults with type 2 diabetes followed for about 8 years, higher soluble fiber intake was linked to fewer strokes, though fiber was not linked to heart disease.Intakes of dietary fiber, vegetables, and fruits and incidence of cardiovascular disease in Japanese patients with type …
- In a case-control study of 384 people with pancreatic cancer and 983 controls, higher soluble fiber intake from food was linked to lower odds of having pancreatic cancer, but this does not show fiber changes cancer risk or helps heart or blood sugar goals.Fruit and vegetable consumption is inversely associated with having pancreatic cancer.
- In 754 black and white teenagers, higher soluble fiber intake from food was linked to lower fasting insulin and insulin resistance, and only soluble fiber was linked to lower blood pressure; average intake was about 4 grams a day, well below recommendations.Total, insoluble, and soluble dietary fiber intake and insulin resistance and blood pressure in adolescents.
- In 627 young rural South African adults, higher total fiber intake was linked to lower fasting blood sugar and blood pressure, and more than 97 percent ate less fiber than recommended.Dietary Fiber Intake and Metabolic Syndrome Risk Factors among Young South African Adults.
- In 117 adults aged 25 to 45 with overweight or obesity, higher total fiber intake recorded over 7 days was linked to lower triglyceride levels.Dietary Fiber Is Independently Related to Blood Triglycerides Among Adults with Overweight and Obesity.
- In 98 adolescents with type 1 diabetes, higher soluble fiber intake was linked to more low blood sugar episodes over one week, though this link disappeared after adjusting for insulin dose.Dietary intake and risk of non-severe hypoglycemia in adolescents with type 1 diabetes.
- In 29 adults having weight-loss surgery, soluble fiber intake was linked to some gut bacteria types before surgery, but the study did not measure blood sugar or heart outcomes.Dietary Macronutrient Intake and the Gut Microbiome in Adults Undergoing Bariatric Surgery for Obesity.
Review Totals and Summary
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Biohacker Summary
Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it
The main ingredient is not clearly identified in the statements, and the panel only spoke about two probiotic strains, both of which are smaller ingredients in this product. Seven of the ten panelists touched on Lactobacillus plantarum, and they mostly mention it rather than endorse it; a few recommend it, one for constipation and one for irritable bowel symptoms, and others cite it for gut balance, mood, memory, and folate. It shows up mostly in fermented foods like sauerkraut, and the only dose detail is a study where people took it once or twice a day. Bacillus coagulans, also a smaller ingredient in this product, is used by two panelists for gut issues and detox support, and one recommends a spore-based form for bloating and digestion. Nobody voiced a caution or said they stopped.
See all 7 biohackers →Hide the biohackers
Siim Land · Lactobacillus plantarum · recommends
- Lists Lactobacillus plantarum as a researched probiotic strain that can degrade microplastics, found in sauerkraut, pickles, sourdough bread, and brined olives.
- Used Lactobacillus plantarum in their study, hoping it would support folate production, and observed a significant increase in circulating methyl folate in participants.
Dr. Eric Berg · Lactobacillus plantarum · neutral
- Explains that lactobacillus plantarum is the dominant microbe in both sauerkraut and kimchi, and it can survive harsh environments like stomach acid, helping to balance good and bad bacteria and prevent leaky gut.
- Dr. Berg notes that Lactobacillus plantarum appears especially beneficial for managing gastroparesis.
- Dr. Berg mentions that kombucha provides Bacillus coagulans.
Dr. Mark Hyman · Lactobacillus plantarum · neutral
- Mentions Lactobacillus plantarum as a protective strain connected with anxiety and mental health issues.
- Mentions that many bacteria, including lactobacillus plantarum, can help produce GABA in the gut, which is a relaxation neurotransmitter.
- Mentions that lactobacillus plantarum influences dopamine and serotonin levels, which are related to anxiety.
- Mentions Lactobacillus plantarum, found in fermented foods like sauerkraut, as an ingredient that helps stimulate T effector memory cells.
- Recommends Lactospore, a shelf-stable, spore-based probiotic (Bacillus coagulans) that has been well-studied and shown to significantly reduce bloating, irritable bowel, vomiting, diarrhea, pain, depression, and improve sleep and quality of life.
- Mentions bacillus coagulans as another soil-based organism that has been shown in clinical studies to be anti-inflammatory and encourage the growth of beneficial bacteria.
- Used Lactobacillus plantarum in their study because a healthy gut microbiome makes B complex vitamins and it has been shown to increase endogenous microbial production of natural folates.
- Recommends Bacillus coagulans as a soil-based organism that has been shown in clinical studies to be anti-inflammatory and encourage the growth of beneficial gut bacteria.
- Used Lactobacillus plantarum in their study because a healthy gut microbiome makes a B complex and this specific probiotic has been shown to increase endogenous microbial production of natural folates.
- Recommends bacillus coagulans, a soil-based organism, as a probiotic that has been shown in clinical studies to be anti-inflammatory and encourage the growth of F. prausnitzii.
Thomas DeLauer · Lactobacillus plantarum · neutral
- Describes a study where subjects were required to take Lactobacillus plantarum, a specific probiotic, per day to support the gut microbiome.
- The study had participants take Lactobacillus plantarum, a specific probiotic strain, two times a day.
- Highlights the inclusion of Bacillus coagulans SNZ 1969 in the Redd Bar, calling it a 'heavily researched blend' of probiotics.
- Recommends consuming Lactobacillus plantarum, found in sauerkraut, for IBS, stating it is tremendous for restoring the gut biome and can dramatically improve symptoms by reducing inflammation.
Ben Greenfield · Bacillus Coagulans · uses
- Uses B. coagulans as one of the bacterial strains in his homemade SIBO yogurt to help control SIBO.
- He uses bacillus coagulans as a binder to help remove compounds from the body as part of the body phase of his detox protocol.
- Ben recommends probiotics like Lactobacillus plantarum for constipation.
- Ben lists Lactobacillus plantarum as a probiotic strain.
Dave Asprey · Lactobacillus plantarum · neutral
- Mentions that some species of lactobacillus plantarum, a common probiotic, can produce uricase.
- Mentions that Bacillus Coagulans is a spore former that maintains its integrity in an aqueous format and helps get the product fully dry, aiding in the fermentation process.
- Dave Asprey takes the Just Thrive Health probiotic because it contains bacillus indicus HU36, which makes compounds beneficial for eye health, and he believes doing both the probiotic and separate supplements is the right approach.
Dr. Rhonda Patrick · Lactobacillus plantarum · neutral
- Cites a study where a daily dose of Lactobacillus plantarum probiotic supplement improved attention, working memory, and verbal memory in individuals with mild cognitive impairment, strongly correlating with increased serum BDNF levels.
RAL Summary
Members OnlyTier 4 for Blood Sugar
Soluble fiber has solid human evidence for lowering blood sugar (54 of 89 studies improved, including large pooled analyses), but with no reviews counted the product cannot rank above emerging.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 20 of the 91 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Digestive system, Endocrine system, Cardiovascular system
Possible side effects: No major side effects reported.
Supplement Facts
Soluble Fiber 3 g · Immuno-LP20 50 mg · Bacillus coagulans Unique IS-2 10 mg
Supplement Facts
Serving Size 2 Gummies
Servings Per Container 24
Amount Per Serving% Daily Value
| Calories | 15 | |
| Total Carbohydrate | 6 g | |
| Dietary Fiber | 3 g | |
| Soluble Fiber | 3 g | |
| Total Sugars | 1 g | |
| Added Sugars | 1 g | |
| Sodium | 15 mg | |
| Immuno-LP20 | 50 mg | † |
| Bacillus coagulans Unique IS-2 | 10 mg | † |
† Daily Value not established.
Other ingredients: Inulin (Chicory Root Fiber), Sugar, Less than 2% of Bacillus coagulans, Black Carrot Juice Extract (color), Carnauba Wax, Citric Acid, Corn Starch, Fractionated Coconut Oil, Heat-killed Lactobacillus plantarum, Lactic Acid, Natural Flavors, Pectin, Sodium Citrate.
Directions: Adults, chew 2 gummies daily. If gas, bloating, or stomach upset occurs, reduce daily serving.
Barcode (UPC) 031604007638 · Label source: Reverseagelab · Report a label change
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