Nature Made Vitamin B12 Review
Nature Made Vitamin B12 1000 mcg Softgels help break down food into energy that your body can use all day long. Sourced from high quality ingredients, this gluten free B12 supplement is a dietary supplement that has no color added (B12 is red in color) and no artificial flavors. These Nature Made B12 1000 mcg softgels help support energy metabolism. Adults take one of these softgels daily with water and a meal. Nature Made supplements are quality you can trust. USP has tested and verified ingredients, potency, and manufacturing process, and USP sets official standards for dietary supplements. The item is part of the Test to be Trusted Program and is sold as one 150 count bottle, described as a 150 day supply. The page states that vitamin B12 helps convert food into cellular energy and that adequate vitamin B12 status helps support a healthy mood. Vitamin B12 is described as important for proper red blood cell formation and as helping to reduce fatigue for those low in B12, and the page says it supports brain cell function. The page describes the product as the number one pharmacist recommended vitamin and supplement brand, based on a survey of pharmacists who recommend branded vitamins and supplements. The page notes that these statements have not been evaluated by the Food and Drug Administration and that the product is not intended to diagnose, treat, cure, or prevent any disease. The supplement contains no synthetic dyes or artificial flavors and is gluten free. Product details show a 150 count bottle weighing 0.14 lbs with CVS item number 800394.
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Study, Trial or Testing Result Summary
Members Only19 human studies · 5 improved
4 of these 19 human studies gave vitamin b12 by injection, not by mouth.
This product gives 1000 mcg of vitamin B12 a day. The evidence that it raises energy in people who are not deficient is weak, but so is the direct evidence against it. A review of 16 randomized trials with 6276 people without deficiency found no benefit for thinking or mood, and only one trial measured fatigue, so fatigue could not be judged [1]. A single 1000 mcg vitamin B12 injection did not ease voice fatigue in 20 singers compared with placebo [2]. Other trials tested mixes with other ingredients rather than vitamin B12 alone. Most used far lower vitamin B12 doses than this product. About three years of low-dose B vitamins did not improve quality of life in 2029 heart patients [3]. Twelve weeks of a multinutrient supplement did not change fatigue in 172 dialysis patients [4]. Four weeks of a combination supplement did not improve performance or fatigue in 41 cyclists [5]. Injections of liver extract with folic acid and vitamin B12 did no better than placebo in 15 people with chronic fatigue syndrome [6]. Overall, there is no good sign that it boosts energy without a deficiency, but few trials have tested vitamin B12 alone for fatigue. Animal and cell studies are never counted.
See all 19 studies →Hide the studies
- Across 16 randomized trials with 6276 people without vitamin B12 deficiency, B12 did not improve thinking or depression, and only one trial looked at fatigue so it could not be analyzed.Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Met…
- In 2029 heart disease survivors, about 3 years of low-dose B vitamins including 0.02 mg B12 did not improve quality of life, and slightly more activity limits from emotional problems were seen.B vitamin and/or n-3 fatty acid supplementation and health-related quality of life: ancillary findings from the SU.FOL.O…
- In 172 dialysis patients who finished, 12 weeks of a multinutrient supplement containing B12 did not change fatigue or quality of life versus placebo, though heart rate variability and a herpes virus measure improved.Effects of nutritional supplementation on fatigue, and autonomic and immune dysfunction in patients with end-stage renal…
- In 41 trained cyclists, 4 weeks of a combination supplement including 2.5 mcg B12 did not improve aerobic or anaerobic performance or fatigue measures compared with placebo, though blood lactate was lower after hard exercise.l-Carnitine and Alpha-Lipoic Acid Fail to Improve Anaerobic and Aerobic Performance in Trained Cyclists Despite a Reduct…
- In 25 healthy recreationally active adults, a single dose of a pre-workout supplement containing vitamin B12 as methylcobalamin, along with caffeine, raised self-reported vigor and energy compared with a placebo drink, though exercise performance did not change.Effects of acute ingestion of a pre-workout dietary supplement with and without p-synephrine on resting energy expenditu…
- In 25 resistance-trained people, a week of a pre-workout drink containing 45 mcg B12 and other ingredients helped maintain some strength and lifting measures versus placebo but did not change cycling time trial performance.Short-Term Effects of a Ready-to-Drink Pre-Workout Beverage on Exercise Performance and Recovery.
- In 20 singers with mild vocal symptoms, a single 1000 mcg B12 injection did not improve voice fatigue or singing measures more than a placebo injection.Effect of Vitamin B12 Injection on the Vocal Performance of Professional Singers: A Randomized, Double-blind, Placebo-Co…
- In 15 people with chronic fatigue syndrome, injections of liver extract with folic acid and B12 worked no better than placebo, which had a strong response.Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome.
- In a chart review of 2142 people with fibromyalgia, 42.4% had vitamin B12 deficiency, and deficiency was linked to higher odds of fatigue (odds ratio 1.39) after adjusting for vitamin D.Association of Vitamin B12, Vitamin D, and Thyroid-Stimulating Hormone With Fatigue and Neurologic Symptoms in Patients …
- In a retrospective study of 689 children without complaints, 23.2% had vitamin B12 deficiency and it was linked to vitamin D deficiency, but no supplement was tested for energy.Is There An Association Between Vitamin B12 Level and Vitamin D Status in Children?
- In 335 older adults, vitamin B12 levels were not associated with frailty, and no supplement was tested.Association between serum vitamin B12 level and frailty in older adults.
- Women with fibromyalgia had lower vitamin B12 levels than 58 healthy women, and lower levels were linked to more tender points, though this study did not test supplements.Could ferritin, vitamin B12, and vitamin D play a role in the etiopathogenesis of fibromyalgia syndrome?
- Vitamin B12 levels were normal in 55 people with primary fibromyalgia, who reported muscle fatigue as one of their most disabling symptoms.Primary fibromyalgia. A clinical and laboratory study of 55 patients.
- In a survey of 38 people with chronic fatigue syndrome or fibromyalgia who had weekly or more frequent B12 injections for six months or more, 15 were good responders who rated themselves much or very much improved, and higher doses and longer use were linked to better response.Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia.
- In a retrospective review of 38 children with neurological symptoms of vitamin B12 deficiency, all recovered within one month of B12 supplementation; fatigue was among the symptoms but was not reported separately.Neurological symptoms of vitamin B12 deficiency: analysis of pediatric patients.
- In a study of 37 adults with pulmonary arterial hypertension, 29% had a functional vitamin B12 deficiency, but no supplement was tested, so the study does not show whether B12 improves energy.Nutritional status in pulmonary arterial hypertension.
- In a small case series of 20 infants with vitamin B12 deficiency, who were treated with cyanocobalamin, clinical and lab findings improved overall, though energy was not separately reported and the dose and duration were not stated.Vitamin B12 Deficiency in Infants.
- All 5 people with ALS who received methylcobalamin injections reported more energy and less fatigue, based on interviews; the dose was not stated.Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
- This survey of hypothetical scenarios found people kept taking B12 for fatigue after a small symptom improvement, showing post hoc bias rather than any real effect of B12 on energy.Post Hoc Bias in Treatment Decisions.
Review Totals and Summary
Members Only18,455 reviews · 93% positive
Nature Made Vitamin B12 has garnered about 18455 ratings across various stores, with a strong majority of customers expressing satisfaction. A significant 80% of rated reviews give this supplement 4 or 5 stars, indicating a generally positive reception for its effectiveness and quality. **What it did for buyers** Many users report positive effects on their energy levels and overall well-being. Customers frequently mention feeling more energetic throughout the day, with some noting that it "helps me gain more energy during the day." The supplement is also praised for supporting the nervous system and metabolism, and for being effective in raising B12 levels, with one user stating it's the "Best one if you want to level up your numbers." It is often described as "good for nervous system and metabolism" and beneficial for overall health, especially for those with deficiencies. **Complaints** While feedback is largely positive, a few concerns were raised. One customer reported an allergic reaction, stating it "give me allergy." Another issue mentioned was receiving a product "too close to expiration date," leading to a return. There was also an implicit complaint about product availability, with a user noting it's an "Awesome product when in stock," suggesting occasional stock issues. **Taste, Smell, and Pill Form** The supplement generally receives high marks for its ease of use. Many reviewers find the tablets "easy to swallow" and appreciate their convenient size, with one noting the "Size of them are perfect." Taste is also not an issue for most, as customers report that the pills "do not taste bad or bitter, no aftertaste either," and some even describe a "good taste." **Value for Money** Customers frequently highlight the good value offered by Nature Made Vitamin B12. The pricing is often described as "very reasonable" and "always good," especially when compared to other store options. Many appreciate the "good sized bottle for the price" and the quantity provided, making it an economical choice for regular use. **Who it suits and who it did not** This B12 supplement appears particularly suitable for individuals managing a B12 deficiency, with many using it for "Daily intake for B12 deficiency" and reporting its effectiveness. It's also favored by those looking for a daily vitamin to boost energy and support general health. The brand's reputation for quality and its simple ingredient list ("All B12. No other ingredients.") appeal to those seeking a straightforward supplement. However, it did not suit one individual who experienced an allergic reaction.
Biohacker Summary
Members Only6 of 10 recommend it
Most of the panel recommends vitamin B12, with five of the ten giving a recommendation as their latest position and a few more using it or staying neutral. They mostly take it for nerve health and myelin, brain function and mood, and to correct a deficiency, with several noting that vegans and older people are at higher risk and that testing levels is wise. The form most often favored is methylcobalamin, with one preferring a liposomal and micellar version for absorption, one suggesting a sublingual form for older people, and one giving a dose of 1 gram in the morning. Pairings mentioned include vitamin B6 and folate, methylated folic acid, and other B vitamins. On the cautious side, one panelist advises against it if the diet already supplies enough, one says to avoid it too close to bedtime, and one stopped taking it alongside fat burner injections and then had a rough period of emotional and hormonal imbalance.
See all 10 biohackers →Hide the biohackers
Thomas DeLauer · Vitamin B12 · recommends
- Recommends Vitamin B12 for mental health and mood, explaining its role in myelination and neurotransmitter production. They specifically recommend a liposomal and micellar form of methylcobalamin B12 for better absorption and to avoid toxicity.
- Mentions that a single serving of sardines provides vitamin B12 at something like three to four times the daily needs.
- Recommends taking methylcobalamin as a methylated form of B vitamin for mitochondrial function.
- Advises against taking vitamin B12 if one's diet already provides enough, suggesting a B complex or liver capsule instead for B vitamins.
- Was taking Vitamin B12 with fat burner injections, which he later stopped cold turkey, leading to a period of intense emotional and hormonal imbalance.
- Warns that high levels of supplemental vitamin B12 are a risk factor for insomnia, as it is an energy-building supplement, and advises taking it in the morning or lowering the dose.
- Notes that depending on one's diet, adding a good multivitamin might be beneficial, specifically recommending a methylated multivitamin for better absorption and utilization.
- Uses Create's Daily Performance Gummy, which contains a multivitamin, a low dose of creatine, adaptogenic mushrooms, and greens, and also adds a separate creatine gummy later in the day.
- Highlights Vitamin B12 as a significant deficiency in studies, important for brain function, oxygen, neurotransmission, and clearing out homocysteine.
- Notes that vegan populations need to supplement to get vitamin B12 because it can only really be obtained from animal products.
Dr. Eric Berg · Vitamin B12 · recommends
- Recommends taking the natural form of vitamin B12, methylcobalamin, to support nerve regeneration, myelin production, and nerve growth factors.
- Notes that Vitamin B12 is intimately involved in the nervous system and may be behind sciatica and carpal tunnel syndrome.
- Recommends taking vitamin B12 if on a med.
- Briefly mentions Vitamin B12 in relation to neuropathy.
- States that vertical ridges on nails could mean a vitamin B12 deficiency, and slightly brown or grey nails, especially for vegans, could indicate low B12. Completely white nails with a pink strip across the top could also be low B12.
- Recommends incorporating vitamin B12 foods into the diet, especially for those who don't regularly consume animal products, to prevent irreversible damage to the nervous system.
- Dr. Berg mentions that fermented dairy contains vital nutrients, including vitamin B12.
- A vitamin B12 deficiency can cause irreversible damage to your nervous system, so it's important to prioritize acidifying your stomach as you age.
- States that Vitamin B12 is crucial for health and many people are deficient without realizing it.
- Mentions that fortified nutritional yeast varieties may provide vitamin B12.
Dr. Mark Hyman · Vitamin B12 · recommends
- States that vitamin B12 is a nutritional deficiency that impacts mental health.
- Recommends vitamin B12 with vitamin B6 and folate as supplements with strong evidence for PMS.
- Mentions that repletion of vitamin B12 can help safely withdraw someone from meds and that simple vitamin B12 deficiencies are important to address in a depression workup.
- Lists Vitamin B12 as important for nerve health and energy.
- Mentions vitamin B12 as a core nutrient required for methylation, noting that deficiencies can lead to various health issues.
- Recommends supplementing with Vitamin B12 for hair follicle health and growth, especially for vegans, as many people are deficient.
- Recommends checking vitamin B12 levels as a first step before taking any supplements.
- Warns that meds (meds) block the absorption of vitamin B12, which requires stomach acid to be absorbed. Long-term B12 deficiency can lead to depression, neurological problems, and dementia.
- Recommends Vitamin B12 in the form of methylcobalamin, about 1000 micrograms a day, as a methylating vitamin necessary for detoxifying and excreting hormones.
- Dr. Hyman states that vitamin B12 deficiency is common, affecting 80-90% of vegans and vegetarians, and over 20% of adults in the general population, often due to acid blockers, digestive issues, or insufficient intake.
Ben Greenfield · Vitamin B12 · recommends
- Recommends getting vitamin B12 tested and supplementing if deficient, as B12 deficiency can cause damage to the myelin coating around nerves, including cochlear nerves, and improve tinnitus severity scores.
- He recommends Vitamin B12, especially for kids on a vegan or vegetarian diet, as it is essential for nervous system development.
- Mentions that blood testing for an energy crisis would include nutritional things like a vitamin B12 level.
- Ben Greenfield consumes vitamin B12 as part of the Update Energy Drink.
- Lists vitamin B12 as a vitamin that, when combined with others, has a neuroprotective effect on the brain.
- Ben notes that vitamin B12 is in the drink, and Shawn specifies it's the methylated coenzymated form, methylcobalamin.
- Mentions that Haya multivitamin contains Vitamin B12.
- Mentions Vitamin B12 as a nutrient found in animal foods that does not occur in plants.
- Ben states that Vitamin B12 is difficult to obtain on a plant-based diet.
- For vegans, Ben Greenfield recommends supplementing with Vitamin B12 to keep nutrient levels topped off, especially before and during a fast.
Dave Asprey · Vitamin B12 · recommends
- States that Vitamin B12 is extremely important for every kind of brain function and recommends ensuring B12 levels are optimal, around 500, not just barely above normal.
- Recommends taking vitamin B12 if one has a deficiency.
- Dave Asprey notes that it's almost impossible to get vitamin B12 in a vegan diet, and it's primarily found in animal meat.
- Clarifies that Vitamin B12 is completely different from Vitamin B3 and is involved in different pathways, so there is no overlap with NAD pathways.
- If one has a MTHFR mutation and cannot process folic acid, Dave Asprey recommends taking vitamin B12 along with methylated folic acid to lower homocysteine levels.
Siim Land · Vitamin B12 · uses
- Created Microvitamin, a supplement that bundled all the supplements he was taking, to help fund his a med trial.
- States that vitamin B12 deficiency is the most common reason for premature graying of hair and recommends fixing B12 status if it is deficient, as it gives a greater likelihood of reversing gray hair.
- Takes 1 gram of Vitamin B12 from DoNotAge in the morning for longevity.
- Mentions Vitamin B12 as a key nutrient involved in the methylation cycle that helps prevent methionine from raising homocysteine levels.
- Explains that one can store up to 30 years' worth of vitamin B12 if they get a lot of it, particularly from superfoods like clams, liver, and oysters, but most people are not in that position.
Andrew Huberman · Vitamin B12 · neutral
- States that a deficiency in vitamin B12 can be terrible and lead to chronic fatigue-like syndromes, as many parts of mitochondria require B vitamins.
- Recommends taking methyl B12 as part of methylated B vitamins to lower homocysteine levels and reduce cardiovascular risk.
- Has been taking AG1 for over 10 years, once and often twice every day, to ensure he gets all necessary vitamins, minerals, probiotics, and adaptogens, considering it a nutritional insurance policy.
- Has been taking AG1 since 2012 to ensure he gets enough vitamins, minerals, Prebiotic fiber, and other nutrients typically found in fruits and vegetables, providing nutritional insurance.
- Andrew Huberman started drinking AG1 in 2012 and still drinks it once or twice a day because it provides all his foundational nutritional needs, ensuring proper amounts of vitamins, minerals, probiotics, and fiber for optimal mental health, physical health, and performance.
- Recommends the consumption of B12 and other B vitamins, especially folate, as it has been shown to partially decrease cancer risk in people who ingest alcohol, though it does not completely offset it.
- Started taking AG1 in 2012 and still takes it once or twice a day because it covers foundational vitamin, mineral, and probiotic needs, and supports immune system function and a healthy gut microbiome.
- He has been using Athletic Greens for over a decade to cover his vitamin and mineral bases and support his gut microbiome, immune system, gut-brain axis, and mental functions.
- Recommends Methyl B12 as part of methylated B vitamins to lower homocysteine and reduce cardiovascular risk.
Dr. Rhonda Patrick · Vitamin B12 · warns
- Warns that Vitamin B12 enhances light's melatonin-suppressing effects and should be avoided too close to bedtime.
- Notes that a med can cause vitamin B12 deficiency, especially as absorption decreases with age, and suggests a sublingual form or B12 injections for older individuals.
- Discusses the origin of Vitamin B12, suggesting it's a microorganism that propagates in the soil and that animals get it from eating dirt, which is why it's less available in modern, sanitized plant foods.
- Describes a study where female mice fed a diet high in B vitamins, folic acid, and vitamin B12 three weeks before pregnancy had offspring that no longer had yellow fur and were not predisposed to obesity and cancer.
- Dr. Rhonda Patrick explores vitamin B12 and autism risk.
- She takes methyl B12 as part of her Thorne multivitamin, which helps keep her homocysteine levels below 9 micromoles per liter.
- Describes a study where female mice fed a diet high in B vitamins, folic acid, and vitamin B12 had offspring that silenced a gene predisposing them to obesity and cancer.
- Supplements with vitamin B12, but also notes many of the foods he eats are fortified with it, and his levels are fine.
Bryan Johnson · Vitamin B12 · uses
- States that Blueprint essential capsules and soft gels are packed with key vitamins and minerals needed for strong bone health.
Peter Attia · Vitamin B12 · neutral
- Notes that deficiencies in certain vitamins and minerals, such as B12, can be a cause of hair loss in women.
- Explains that when a person is not responding to traditional B vitamins, they will step it up and give them methylcobalamin B12.
- Notes that Ryan Lochte was suspended for a doping rule violation after a social media post showed him taking vitamin B12 in an illegal way, by IV infusion.
RAL Summary
Members OnlyTier 4 for Energy
The ineffective grade rests mostly on trials of multi-ingredient blends with tiny vitamin B12 doses and on a review that could not analyze fatigue, so the evidence that vitamin B12 alone fails for energy is thin rather than good. So it is graded Tier 4, as the studies disagree.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 13 of the 19 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Nervous system, Blood
Combine with: To further enhance energy levels, consider combining Vitamin B12 with a B-complex vitamin to ensure all essential B vitamins are present for optimal metabolic function. Coenzyme Q10 (CoQ10) can also be beneficial as it plays a crucial role in cellular energy production. For sustained energy and to combat fatigue, magnesium is a good addition, as it's involved in over 300 enzymatic reactions, including ATP synthesis. If fatigue is also linked to stress, adaptogens like Ashwagandha or Rhodiola could provide additional support.
Possible side effects: No major side effects reported. One trial of low-dose B vitamins saw slightly more activity limits from emotional problems.
Supplement Facts
Vitamin B12 1000 mcg
| Vitamin B12 (as Cyanocobalamin) | 1,000 mcg | 41,667% |
Other ingredients: Soybean Oil, Gelatin, Glycerin, Yellow Beeswax, Lecithin.
Directions: SUGGESTED USE: Adults, take 1 softgel daily with water and a meal. Store tightly closed, in a cool, dry place, out of reach of children. Do not use if seal under cap is broken or missing.
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Graded October 26, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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