Nature Made Vitamin B6 100 mg Review
Product Focus: Occasional Heartburn: Fast ReliefAlso covers:Digestion
Tier ⓘ
Tier 4 · Rank 8
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 8 within Tier 4 for Occasional Heartburn: Fast Relief; 17 of 26 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
15 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Biohacker Mentions
0 of 10
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Study, Trial or Testing Result Summary
Members Only14 human studies · 8 improved
14 human studies8 improved6 no effect13,149 people studied
There is no good evidence that vitamin B6 on its own gives fast relief from occasional heartburn, and none of the vitamin B6 studies tested quick relief. In a trial of 351 adults with acid reflux, a blend of melatonin, vitamin B6 and other nutrients relieved symptoms in everyone who took it after about 40 days, compared with about two thirds of people on a standard acid-reducing drug, but the effect of vitamin B6 itself cannot be separated from the other ingredients [1]. A study of 11,690 people linked more vitamin B6 in the diet to lower odds of one type of reflux, but this cannot show cause [2]. A study of 450 women found the opposite, linking higher intake to more reflux [3]. A study of 328 young adults found no direct link with reflux [4]. In a two-week trial, a drink with a small amount of vitamin B6 and other ingredients caused heartburn in 10 of 25 people [5]. This product also has calcium, but only 30 milligrams, far below the 420 milligram dose of calcium carbonate that eased heartburn quickly in a placebo-controlled trial [6]. Other short trials of calcium antacids at full doses showed fast but short-lasting effects [7][8]. Animal and cell studies are never counted.
See all 14 studies →Hide the studies
- In 351 adults with acid reflux disease, a blend containing vitamin B6 plus melatonin and other nutrients led to complete symptom relief in all 176 people after 40 days, versus 65.7% of those taking a med, though the vitamin B6 effect cannot be separated from the other ingredients.Read the study on PubMed (16948779) →
- In 155 adults with frequent heartburn, as-needed calcium carbonate antacid for 12 weeks worked less well than twice-daily effervescent ranitidine, with more rescue antacid use and less healing of the oesophagus (29% vs 55%), though quality of life improved with both.Managing heartburn at the 'base' of the GERD 'iceberg': effervescent ranitidine 150 mg b.d. provides faster and better h…
- In 49 adults with constipation-type irritable bowel syndrome, a drink with 2 mg vitamin B6, inulin and menthol taken for 2 weeks improved bowel symptoms but caused noticeable heartburn in 10 of 25 people who drank it.[Using a multicomponent functional food in IBS patients with constipation a comparative controlled study].
- In 26 adults with frequent meal-related heartburn, a single 420 mg dose of calcium carbonate lowered acidity in the oesophagus and reduced heartburn severity compared with placebo.Synergy between low-dose ranitidine and antacid in decreasing gastric and oesophageal acidity and relieving meal-induced…
- In 24 adults given a heartburn-provoking meal, single doses of calcium carbonate gum or chewable tablets reduced heartburn and raised oesophageal pH within 15-30 minutes compared with placebo, with the gum lasting longer than the tablets.Clinical effectiveness of a new antacid chewing gum on heartburn and oesophageal pH control.
- In 24 healthy volunteers, a single dose of a calcium and magnesium carbonate antacid raised stomach pH within the first 30 minutes compared with no treatment, but the effect was short-lasting.Comparison of two antacid preparations on intragastric acidity--a two-centre open randomised cross-over placebo-controll…
- In 24 adults with a history of reflux, a chewing gum containing calcium carbonate and other ingredients lowered heartburn and acid reflux scores after a trigger meal compared with placebo gum.Effect of GutsyGum(tm), A Novel Gum, on Subjective Ratings of Gastro Esophageal Reflux Following A Refluxogenic Meal.
- In 16 healthy fasting volunteers, a single 1360 mg dose of calcium-magnesium carbonate antacid raised stomach pH above 3 in a median of 5.8 minutes versus 240 minutes with placebo, acting faster than two acid-reducing drugs but wearing off sooner.Comparison of the effect of the antacid Rennie versus low-dose H2-receptor antagonists (ranitidine, famotidine) on intra…
- In people with nonulcer dyspepsia, calcium carbonate was linked to more reflux symptoms in those with a stomach lining condition (multifocal atrophic gastritis) once their Helicobacter pylori infection was cleared.Increased reflux symptoms after calcium carbonate supplementation and successful anti-Helicobacter pylori treatment.
- A new alginate and calcium carbonate liquid formed a raft and stayed in the stomach about as well as an existing Gaviscon liquid; the study did not measure heartburn relief in people.Alginate-antacid combinations: raft formation and gastric retention studies.
- In 12 healthy volunteers, a single 20 mL dose of an alginate antacid containing calcium carbonate significantly reduced food and acid reflux into the oesophagus after a test meal compared with no treatment.Effect of alginate and alginate-cimetidine combination therapy on stimulated postprandial gastro-oesophageal reflux.
- In a study of 11,690 people who had endoscopy and diet records, higher dietary vitamin B6 intake was linked to lower odds of non-erosive reflux disease, though this does not prove cause.Gender-specific Effect of Micronutrient on Non-erosive Reflux Disease and Erosive Esophagitis.
- In a case-control study of 150 women with reflux and 300 controls in Iran, higher dietary vitamin B6 intake was linked to higher odds of reflux disease.Dietary Vitamin B6 Intake and Gastroesophageal Reflux Disease: A Case-Control Study.
- In a cross-sectional study of 328 young adults, lower dietary vitamin B6 intake was linked to higher overall gastrointestinal symptom scores, but vitamin B6 intake was not directly linked to reflux status.Health cooking at home: can cooking skills reduce gastrointestinal symptoms, cross sectional study?
Review Totals and Summary
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Biohacker Summary
Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it
The product is vitamin B6, but the panel's statements are split between B6 and calcium, so the B6 picture rests on only four of the ten. Two of them recommend it: one for PMS alongside folate and B12 and for a child with low levels, and one for people with a gene variant that affects B6 levels, who may need more from food or supplements. Two of them warn: one avoids the common synthetic form (pyridoxine hydrochloride) and prefers the active form, P5P, for nerve health, and one does not supplement B6 at all because too much can damage peripheral nerves. Beyond that, one mentions B6's role in methylation and another links it to nerve problems like sciatica and carpal tunnel syndrome, and none of them give a dose.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Calcium · warns
- Warns that bone loss cannot be fixed with just calcium, as bone is primarily collagen with other essential minerals.
- Dr. Berg includes calcium carbonate among the synthetic supplements to avoid.
- Dr. Berg lists pyridoxine hydrochloride as a synthetic vitamin to avoid.
- Recommends taking the active form of vitamin B6, pyridoxal-5-phosphate (P5P), for its benefits to the nervous system, including building the myelin sheath and protecting sensory nerve integrity.
- Notes that Vitamin B6 is intimately involved in the nervous system and may be behind sciatica and carpal tunnel syndrome.
- Warns against calcium carbonate, also known as limestone, stating that while it lowered hip fractures in a study, it also increased kidney stones and is not good for arteries, requiring the body to work hard to use it.
- Notes that tannins in tea bind calcium, blocking its absorption.
- States that high vitamin B6 levels can be linked to peripheral neuropathy.
- Indicates that horizontal thin white lines near the base of the nails are indicative of low calcium.
- Warns that calcium carbonate can build up in the arteries and kidneys and increase the risk of a heart attack.
- Dr. Berg mentions that fermented dairy contains vital nutrients, including calcium.
- States that calcium and magnesium are intrinsically linked and work in combination with vitamin D to support the body's calcium balance.
- Explains that calcium triggers muscle contraction, while magnesium is needed to relax the muscles afterward.
- Warns that too much calcium can cause high blood pressure by causing arterial contraction.
Siim Land · Calcium · neutral
- Lists dairy and sardines as sources of Calcium.
- Notes that Boron reduces calcium/magnesium loss.
- Recommends a high calcium intake for bone health.
- Places calcium supplementation in the 'bad tier' due to its association with increased cardiovascular events, recommending dairy or bones as easier ways to get calcium, though it can be useful for postmenopausal women with low bone density.
- Mentions that eating enough calcium matters for bone density, but states that it alone won't transform bone density.
- Warns that calcium is linked to a higher risk of heart disease, though people with low calcium status and intake can take it safely.
- Warns that calcium supplements increase the risk of heart disease by raising blood calcium levels too high, leading to hypercalcemia and more calcium being stored in the arteries, and also increase the risk of arrhythmias.
- Warns against calcium supplementation for most people due to its association with increased cardiovascular events, but notes it can be useful for postmenopausal women with low bone density who don't consume dairy.
- Discusses Calcium as a supplement.
- Recommends consuming calcium from dairy, tofu, leafy greens, and bones, as it is a key nutrient required for ATP synthase in mitochondrial energy production.
- Mentions that insufficient vitamin B6 can raise prolactin levels.
- Recommends B12 for vegans, noting it is a standard vitamin found in animal products.
- Is experimenting with serine plus vitamin B6 to impact homocysteine levels, a mechanistic hypothesis he is testing.
- Takes 1 gram of Vitamin B6 from DoNotAge in the morning for longevity.
Thomas DeLauer · Calcium · neutral
- Notes that milk contains 120mg of calcium, while sardines contain 351mg, highlighting a 3x difference.
- Recommends getting calcium, along with vitamin D, zinc, and magnesium, from foods like sardines, as they are important for inflammatory pathways in the gut.
- Explains that eating sardines with their soft bones provides a serious hit of calcium, which is a perfect combination for bones and may contribute to satiety.
- Mentions that magnesium and calcium should not be taken together as they cancel each other out.
- Tries to get multivitamins without calcium or with a low amount, as he believes supplemental calcium impacts the absorption of other vitamins and minerals and is not as beneficial as hyped. He cautions against it for most people due to the risk of coronary artery calcification.
- Recommends getting calcium from dairy sources like milk, yogurt, kefir, and cheese in the morning to support neurotransmitter synchronization crucial for deep and REM sleep, noting that low dietary calcium is linked to insomnia.
- Warns that calcium competes with magnesium for the same absorption channels, advising to separate magnesium intake from calcium supplements or dairy by at least an hour or two.
- Recommends ensuring adequate vitamin B6 intake, as it is a required cofactor for cells to use absorbed magnesium and improves central nervous system relaxation when combined with magnesium.
- Recommends vitamin B6 to support GABA production and find balance for mental clarity.
- Recommends providing the body with adequate dietary calcium, not a calcium supplement, to ensure a clean, strong spark for efficient insulin release.
- Warns that calcium and magnesium should not be taken together as they cancel each other out, though some products use delayed absorption to mitigate this.
- Warns that most people consume too much calcium relative to magnesium, which can disrupt the balance needed for proper bodily function, comparing it to an electrical circuit.
- Mentions B12 as a critical B vitamin for reducing homocysteine.
- Notes that depending on one's diet, adding a good multivitamin might be beneficial, specifically recommending a methylated multivitamin for better absorption and utilization.
Dr. Mark Hyman · Vitamin B6 · uses
- Optimized a child's nutrient status with vitamin B6, as the child had low B6 levels.
- Notes that calcium is in bones but is also essential for nerves, muscles, and the heart, and low levels can affect muscle function and heart rhythm.
- Recommends vitamin B6 with folate and B12 as supplements with strong evidence for PMS.
- States that green leafy vegetables are great sources of calcium.
- Believes that if functional testing is done to replete deficiencies like vitamin D and B12 before someone stops their medication, withdrawal symptoms can be completely eliminated.
- Notes that calcium needs are lower than advertised and that stress, soda, and excess sugar can drive calcium loss.
- Does not prescribe calcium supplements at all, teaching people to get it from whole foods instead, because calcium supplements don't work for building bones or preventing fractures, and it's bone quality, not density, that matters.
- Warns that acid blockers inhibit calcium absorption.
- Lists calcium as another important nutrient that people can be tested for and measured.
- States that high doses of calcium supplementation in the elderly were not really impacting bone density, as osteopenic patients still became osteoporotic.
- Warns that meds (meds) impair the absorption of calcium, which increases the risk of hip fractures and osteoporosis.
- States that Vitamin B6, at 50 to 100, is important for estrogen metabolism.
- Recommends calcium citrate, about 600 milligrams a day, for bone health, noting that much can also be obtained from diet through leafy greens, sesame seeds, tahini, and chia seeds.
- Dr. Hyman notes that while calcium deficiency is not common in terms of blood levels, insufficient intake can lead to osteoporosis as the body pulls calcium from bones. He advises caution with calcium supplementation due to potential heart issues.
Dr. Rhonda Patrick · Calcium · neutral
- Mentions that kale delivers calcium, a micronutrient many diets fall short on.
- Notes additional gaps in calcium.
- Reports that alcohol use disorder is associated with a 20-50% greater prevalence of Calcium deficiency.
- Around 38% doesn't meet the requirement for calcium.
- Dr. Patrick states that people with a specific gene polymorphism in the NPF3 gene, which affects vitamin B6 levels, may need to increase their dietary intake of B6 and/or supplement with vitamin B6.
- Takes a calcium-magnesium pill because he believes people tend to be short of both and that the body cares about the ratio of these similar molecules.
- Vitamin B6 can suppress the production of Advanced Glycation End products.
- States that 1,000 milligrams of calcium per day is the recommended intake for bone density, and supplementation is an option if this requirement is not met.
- Takes a calcium, vitamin K2, and vitamin D combination supplement in the morning, providing about 600 mg of calcium and another 1,000 IUs of vitamin D.
- Dr. Rhonda Patrick discusses calcium needs.
- Dr. Rhonda Patrick explores high-dose vitamin B6.
- Notes that very high doses of vitamin B6 can overcome a specific mutation in the ornithine aminotransferase enzyme, preventing progressive blindness.
Dave Asprey · Calcium · neutral
- Notes that when energy intake is too low for training demand, nutrient intake often falls short, especially for calcium, which is associated with reduced bone health.
- Explains that calcium provides the raw material for bones, but it isn't a standalone input and needs a whole system to be effective.
- Notes that people take calcium for their bones.
- Warns that taking calcium without vitamin D, A, and K2 can lead to calcium going into tissues, causing bone spurs and other issues, and recommends a two-to-one ratio of calcium to magnesium.
- Mentions Vitamin B6 as playing a role in methylation pathways.
- Recommends taking calcium citrate during a high oxalate meal to bind the oxalate in the gut.
- Notes that people often take calcium for bone health.
- Believes calcium supplements are overrated, as most people need more vitamin K2 and vitamin D instead.
- Warns that the synthetic form of vitamin B6 found in almost all multivitamins and energy drinks binds to B6 receptors for a thousand days, making them unavailable for the beneficial form.
- Advises taking iron and calcium separately because they will bind together.
- Takes extra calcium to help deal with the burden when eating chocolate or anything with higher levels of oxalates.
- Discusses calcium citrate as a counter to oxalate crystals, specifically when consumed through dairy, but questions if it's the primary form of calcium in dairy.
- Says they would take a bunch of their Wild Lights Vitamin B6 if they had to eat almonds, to try and pass them.
- Warns about formulating with Vitamin B6.
Ben Greenfield · Calcium · neutral
- Is considering whether he needs a calcium supplement because lead can displace calcium in bones, affecting bone strength.
- Mentions calcium as a common deficiency.
- Recommends adequate intake of calcium for bone strength.
- Is using calcium chloride mixed with PRP before injecting for the P-shot.
- Advises people to stop taking calcium supplements as part of the Root Cause Protocol.
- Warns that in high doses, calcium without the right cofactors can raise cardiovascular risk by contributing to arterial calcification instead of bone strength, and may increase the risk of osteoporosis.
- Recommends Vitamin B6 for the conversion of tryptophan to serotonin and then melatonin in the pineal gland.
- Explains that 10X separates calcium and zinc into different micro beads, releasing them at different rates and locations in the digestive tract to prevent competition and optimize absorption.
- Covers calcium as a key supplement for kids.
- Warns of calcium deficiency on a carnivore diet, as there is not an appreciable amount in meat, and recommends eating fish with bones or taking a calcium supplement or bone mineral matrix.
- Lists vitamin B6 as a vitamin that, when combined with others, has a neuroprotective effect on the brain.
- Leland ensures adequate Vitamin B6 for patients to optimize endogenous melatonin production.
- Ben recommends HIYA Kids Multivitamin as a pediatrician-approved, superpowered chewable multi that is zero sugar, non-GMO, vegan, dairy-free, allergy-free, gelatin-free, and nut-free, formulated with 12 organic fruits and veggies and 15 essential vitamins and minerals.
- Warns that most typical children's vitamins are basically candy in disguise, containing two teaspoons of sugar, unhealthy chemicals, and gummy junk that growing kids should never eat.
Peter Attia · Calcium · recommends
- Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
- Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
- Recommends calcium for bone health, stating that teenagers probably need about 1000 milligrams a day.
- Discusses bone acting as a reservoir for calcium and how resorption and formation release calcium into the blood when needed.
- Notes that bone is 50 to 70 percent mineral, with calcium being the predominant mineral, and virtually all of the body's calcium is contained within bone.
- Recommends getting about a gram of calcium a day from organic bone meal, which provides calcium hydroxyapatite, the form humans are meant to consume.
- Suggests that calcium is one of the other signals involved in regulating mitochondrial number, beyond AMPK activation.
- States that in postmenopausal women not on estrogen, calcium and vitamin D have no protective effect against hip fracture because the problem is not the shell of the bone, which is fed by calcium and vitamin D, but the internal girder network.
- Notes that compelling evidence links calcium to reduced risk of osteoporosis, which can impact mortality from specific causes.
Bryan Johnson · Calcium · recommends
- Recommends calcium as a mineral that, along with phosphorus, magnesium, and boron, is deposited to fortify the bone structure after the collagen scaffold is in place.
- Agrees that a little extra calcium is probably okay, especially for women, to really hit home for bone mineral density.
- Recommends prioritizing calcium intake for postmenopausal women to help maintain bone density and reduce the risk of osteoporosis.
- Bryan Johnson takes Calcium daily as part of his Longevity Mix, which supports healthy bones and teeth.
- Recommends continuing with calcium to support bone health during the follicular phase.
Andrew Huberman · Vitamin B6 · warns
- Does not supplement B6 due to evidence that overs-supplementing vitamin B, especially B6, is problematic because of peripheral nerve damage.
- Notes that some people are exploring the use of P5P, a metabolite of vitamin B6 known to suppress prolactin, as a way to buffer the post-MDMA crash, though there are no human data yet.
- Discusses "hard water" and the role of magnesium and calcium in cardiovascular health.
- Recommends P5P, which is vitamin B6, as a dopamine agonist to help with low drive and motivation.
- Described how some people take vitamin B6 to reduce prolactin levels and thereby reduce the duration of the refractory period, but he is not suggesting anyone do this.
- Mentions Vitamin B6 as a mild prolactin inhibitor.
- Huberman states that he used to take a couple hundred milligrams of vitamin B6 after major events to offset the post-achievement low, noting it seemed to have a positive effect, but advises caution for those with diabetic neuropathy.
- Notes that some people are exploring the use of P5P, a metabolite of vitamin B6 known to suppress prolactin, as a way to buffer the post-MDMA crash, but there are no human data yet.
- He mentions that B6 and NMN are where the Krebs cycle starts to kick in, and all B vitamins basically run that entire circle.
- Adequate intake of calcium is vital for bone health.
RAL Summary
Members OnlyTier 4 for Occasional Heartburn: Fast Relief
Emerging because the only trial suggesting benefit tested vitamin B6 in a blend with melatonin and other nutrients, the diet studies disagree, none tested fast heartburn relief, and there are no reviews. The calcium is a trace amount well below the dose that worked in studies.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 6 of the 14 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Digestive system
Possible side effects: In one small trial, a drink containing vitamin B6 with inulin and menthol caused heartburn in 10 of 25 people; no reviews were available.
Supplement Facts
Vitamin B6 100 mg · Calcium 30 mg
Other ingredients: Cellulose Gel, Croscarmellose Sodium, Hypromellose, Maltodextrin, Magnesium Stearate.
Directions: Suggested use: For adults, take one tablet daily with a meal. For easier swallowing, take with water before and during ingestion.
Barcode (UPC) 031604012854 · Label source: NIH label database · Report a label change
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Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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