Nutrafol DHT Inhibitor Review
Nutrafol DHT Inhibitor is a dietary supplement sold in capsule form. The label lists a serving as 2 capsules, and each container holds 30 servings. That means a full container has 60 capsules at the labeled serving size. The supplement facts panel lists four plant extracts per serving. Nettle root extract is listed at 100 mg. African Cherry Tree Bark Extract is listed at 100 mg. Reishi Mushroom Fruit Extract is listed at 400 mg. Magnolia Tree Bark Extract is listed at 200 mg. Together, the four extracts add up to 800 mg per serving as printed. The other ingredients printed on the label are cellulose, rice husk, and a rice extract blend. These make up the rest of the capsule contents and the capsule itself. No directions for use are printed in the label information provided, so check the packaging in the store for any instructions, warnings, or allergen notes before you decide. The serving size and servings per container shown above are the figures to compare against other products on the shelf.
We don’t sell supplements. We help you make decisions and get the best price.
Lowest prices
We may earn a commission from some store links. How we choose.
Finding the lowest prices at the stores now. This takes a few seconds.
Study, Trial or Testing Result Summary
Members Only7 human studies · 5 improved
No study has measured biological age with this product or its ingredients. Reishi mushroom is at a full dose. In a six-month trial in 42 healthy adults, 225 milligrams a day raised antioxidant capacity and lowered markers of oxidative damage, including one tied to DNA damage [1]. An earlier four-week trial in 18 healthy adults taking a higher dose found no change in antioxidant, DNA damage, immune or inflammation markers [2]. Nettle root here is 100 milligrams, below the 450 milligrams that lowered inflammation and oxidative stress markers in men with an enlarged prostate [3]. Small trials in people with type 2 diabetes found nettle extract raised antioxidant enzymes [4], but one found no change in a marker of fat damage [5]. For magnolia bark, the only human study used a facial serum on the skin, not a pill, and had no placebo group [6]. A study of a magnolia compound that found less DNA damage was done in mice and cells, not people [7]. African cherry tree bark has no human studies for this goal. Animal and cell studies are never counted.
See all 7 studies →Hide the studies
- In 60 men with enlarged prostate, 450 mg a day of nettle root extract for 12 weeks improved prostate symptom scores and lowered markers of inflammation and oxidative stress compared with placebo.Urtica Dioica Root Extract on Clinical and Biochemical Parameters in Patients with Benign Prostatic Hyperplasia, Randomi…
- In 50 people with type 2 diabetes, nettle extract for 8 weeks raised total antioxidant capacity and superoxide dismutase compared with control, but did not change malondialdehyde or glutathione peroxidase.The effect of hydro alcoholic nettle (Urtica dioica) extract on oxidative stress in patients with type 2 diabetes: a ran…
- In 50 women with type 2 diabetes, nettle extract for 8 weeks increased the antioxidant enzyme superoxide dismutase and nitric oxide and improved blood sugar, triglycerides and HDL compared with placebo.Effects of Urtica dioica supplementation on blood lipids, hepatic enzymes and nitric oxide levels in type 2 diabetic pat…
- In 42 healthy adults taking 225 mg of enriched reishi daily for six months in a crossover design, antioxidant capacity and enzymes rose, oxidative damage markers (TBARS and 8-OH-dG) and liver enzymes fell, and mild fatty liver reversed to normal on ultrasound.Triterpenoids and polysaccharide peptides-enriched Ganoderma lucidum: a randomized, double-blind placebo-controlled cros…
- In 18 healthy adults taking 1.44 g of reishi daily for 4 weeks in a placebo-controlled crossover trial, no significant change was found in antioxidant, DNA damage, immune, or inflammation markers, with no signs of toxicity.Ganoderma lucidum ("Lingzhi"), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation s…
- In 44 adults aged 35 to 69 with moderate to severe facial aging, a facial serum containing magnolol, used twice daily for 12 weeks, improved skin hydration, elasticity, and collagen and elastin levels; the study had no placebo group.A Multi-Center Clinical Trial to Evaluate the Efficacy of the Next Generation TriHex Technology Antiaging Regimen.
- In mice and heart muscle cells, honokiol, a compound found in magnolia bark, lowered oxidant levels and DNA damage and helped protect heart pumping function in a heart disease model; it has not been tested in people in this study.Loss of Nuclear Envelope Integrity and Increased Oxidant Production Cause DNA Damage in Adult Hearts Deficient in PKP2: …
Review Totals and Summary
Members Only11 reviews · 87% positive
No written reviews read yet.
Biohacker Summary
Members Only6 of 10 recommend it
Five of the seven panelists who spoke about nettle recommend it, and one is neutral, so the panel leans favorable. They name different uses: blocking or lowering DHT for hair loss or acne, in one case paired with saw palmetto, helping with histamine intolerance, and anti-inflammatory tea. One suggests the leaf in smoothies or tea, the seeds for testosterone and the root for keeping testosterone from turning into estrogen. Nobody gave a dose. One panelist cautioned that nettle is purported to free up testosterone but the research points to strong effects on the prostate and liver, which makes it a tricky ingredient. Reishi is a smaller ingredient in this product, and most of the panel recommends it for calm, sleep and immune support, though three of them have stopped using it.
See all 8 biohackers →Hide the biohackers
Dave Asprey · Nettle · recommends
- Recommends nettle root as a natural way to block DHT for guys experiencing baldness or hair loss caused by DHT.
- Notes that scientists are studying Reishi for its effect on longevity, immune balance, cellular resilience, and telomere preservation.
- Recommends full spectrum reishi mushroom as part of Nootropics by Peak for calm, sustained energy, sharper focus, and long-term resilience.
- Notes that reishi mushroom is being studied for its effects on longevity, immune balance, cellular resilience, and preserved tie.
- Recommends Reishi for longevity, stating that it supports mitochondria, protects telomeres, reduces inflammation, and helps cells stay resilient.
- Mentions Reishi, also known as the immortality mushroom, as the anchor of the Nanduka formula, noting that researchers are exploring its potential to protect telomeres as part of a longevity strategy.
- Mentions Reishi, also known as the immortality mushroom, as an anchor of the Nadurra formula, with researchers exploring its potential to protect telomeres as part of a longevity strategy.
- Dave notes that Nandaka contains a high concentration of full-spectrum reishi spore powder for calm and focus.
- Dave notes that Nandaka contains full spectrum reishi spore powder for calm and focus.
- Warns that Reishi mushroom at high doses can be problematic for some guys if they have low baseline DHT in the first place, as it suppresses the five alpha reductase pathway.
- Recommends Reishi mushroom as a natural way to block DHT for guys experiencing baldness or hair loss caused by DHT.
- Mentions that one can make an argument for Reishi but emphasizes focusing on what the body needs.
- Dave Asprey notes that the client takes Life Cycle Australian mushroom extracts, including turkey tail, which are good for the gut.
- States that their beers are bitter with reishi, which they use to offset some of the less desirable properties of alcohol.
Thomas DeLauer · Nettle · recommends
- Recommends nettle, highlighting its versatility: the leaf can be used as a micronutrient supplement in smoothies or as tea, the seeds for testosterone purposes, and the root as an aromatase inhibitor to help with testosterone leaking into estrogen.
- The best sources of beta-glucans are shiitake mushrooms and reishi mushrooms.
- Mentions Reishi mushroom as one of the top adaptogenic compounds in traditional Chinese medicine, often found in formulas.
- Recommends adding reishi mushroom, reishi decaf, or reishi supplements after 3 p.m. to help calm down.
- Recommends Reishi mushroom, an adaptogen, to support the body's built-in defenses and help adapt to stressors.
- Mentions magnolia bark as a potentially more bioavailable form of GABA, but warns that taking it too much can lead to dependency.
- Shares his personal experience with Reishi, finding that it works best for him in the morning to provide a sense of calm and take the edge off, rather than in the evening for winding down, which he found counterintuitive and sometimes backfired.
- Recommends Reishi mushroom for relaxation and a sedative-like effect without the negative impact on the gut that alcohol has.
- Is implementing more Reishi mushroom, noting that being calm and in a parasympathetic state helps with appetite control and making better food choices.
- Uses Reishi mushrooms for stress.
- Mentions Reishi mushroom as another adaptogen often considered for stress, similar to ginseng.
- Recommends Reishi as a powerful mushroom adaptogen for helping to calm down.
- Notes that Organifi Red Juice Powder includes Reishi, an adaptogenic mushroom to help feel more calm and relaxed.
- Likes the Four Sigmatic mushroom stuff as part of his intuitive morning drink choice.
Dr. Eric Berg · Nettle · recommends
- Recommends nettle tea as a great anti-inflammatory tea.
- Reishi mushrooms improve cognitive and immune function and also provide a calming effect, but unlike ashwagandha, they don’t affect cortisol.
- Mentions that Reishi mushroom is a great adaptogen for cognitive function, immune function, and a calming effect, but it does not have an effect on cortisol.
- Reishi mushrooms and other types of mushrooms are natural immunomodulators.
- Mentions Reishi mushroom as a natural remedy that deals with cancer.
- Recommends nettle root as a natural inhibitor of DHT, which can help with hair loss.
- Recommends Reishi mushroom as a natural alternative to a med for anxiety, stress, cortisol, and sleep.
- Recommends nettle root as a great anti-inflammatory for allergies and inflammation, suggesting it can be added to quercetin for a more potent effect.
- Warns that nettle tea can stimulate contractions of the uterus, which is not good for early pregnancy.
- Suggests magnolia bark as a natural remedy that may work as well as meds for some people, mimicking their properties and offering benefits like anti-anxiety effects, improved sleep, and inhibition of epileptic seizures.
- Explains that Reishi mushroom can increase natural killer cells, which kill cancer cells and destroy viruses, and also increase white blood cells, decrease fatigue, and help stabilize blood sugar.
- Lists Red Reishi Mushroom as a natural herb that can help lower testosterone or other excess androgens.
- Recommends Magnolia as a great herb that increases DHEA, which acts as a buffer for cortisol, and helps inhibit high levels of cortisol.
- Mentions that Red Reishi mushroom has significant effects in reducing the 5-alpha reductase enzyme, prostate enlargement, and acne.
Dr. Mark Hyman · Nettle · recommends
- Mentions adding nettles as a supplement to help with histamine intolerance.
- Recommends reishi mushrooms for their powerful immune-boosting and anti-cancer compounds.
- Notes that Nandaka contains full spectrum Reishi, which is studied for immune signaling and cellular stress response.
- Notes that Magnolia Bark binds to separate allosteric sites on the GABA receptor, increasing the amount of GABA to bind.
- Recommends magnolia as an herbal supplement for deep sleep and relaxation, especially for those who are tired, wired, and stressed.
- Mentions magnolia as an herb that can be helpful for sleep.
- Mentions reishi mushrooms as one of many phytochemicals that influence the AMPK pathway and have similar benefits to a med.
- Mentions Reishi mushrooms as helpful for getting the gut microbiome sorted.
- Suggests trying magnolia as an herb that can be very helpful for sleep.
- Loves reishi, a mushroom, for giving energy in the evenings and helping with sleep.
- Recommends adaptogenic mushrooms like Reishi as very effective for helping modulate the nervous system.
- Suggests that herbs like magnolia can be very helpful for sleep.
- States that mushrooms like Reishi can be very helpful as adaptogens to help lower the stress response.
- Includes Reishi in his daily mushroom cocktail and notes it is good for general adaptogenic properties and helping with chronic stress.
Ben Greenfield · Nettle · recommends
- Mentions using stinging nettles to lower DHT, citing an example where it was used with Saw Palmetto to prevent cystic acne from testosterone.
- Has been adding a scoop of MushyLove, a medicinal mushroom blend by THE MEDICIN, to his morning coffee.
- States that Reishi mushroom promotes relaxation pathways involved in the transition into sleep, influencing biological systems tied to sleep quality.
- Ben Greenfield's nighttime routine for sleep includes reishi.
- Notes that AHCC outperforms Reishi, which they had previously raved about.
- Uses Reishi mushroom, as part of IM8 Health, to ease into a natural drift-off for sleep.
- Likes some of the adaptogenic blends by Four Sigmatic Mushrooms for helping him tone things down for an afternoon nap.
- Ben Greenfield says he uses Reishi, specifically Four Sigmatic Reishi with bone broth, with lunch to help him relax and detangle his brain without feeling groggy.
- Ben Greenfield uses adaptogenic blends from Four Sigmatic Mushrooms to help him nap.
- Will reveal how certain adaptogens like reishi extract can make naps even more rejuvenating.
- Ben Greenfield stirs Reishi extract into bone broth or water with lunch to help him nap.
- Uses reishi quite a bit in the afternoons, particularly with lunch, to calm down without feeling groggy, especially before a siesta, neurofeedback, meditation, or hyperbaric session.
- Mentions that reishi mushroom extract can help with blood flow.
- Recommends switching to adaptogens like reishi in the late afternoon to allow for wakefulness without disrupting sleep patterns.
Andrew Huberman · Nettle · neutral
- Discusses nettles in relation to the prostate, boron, and the blood brain barrier.
- Recommends Reishi as one of the two big medicinal mushrooms they look to and often have women use.
- Mentions Reishi Mushroom as one of many herbal compounds that people claim can increase hair growth, but notes a lack of robust clinical studies.
- Huberman mentions that stinging nettles are purported to free up testosterone but warns that the literature points to potent effects on the prostate and liver, making it a potentially tricky molecule.
Siim Land · Reishi · stopped
- Used to take Reishi in the past but no longer does, as he has already tested most supplements.
- Has tried many different forms of Reishi, including tinctures, capsules, and tea, and found that they all appear to work, with no noticeable difference between the oral tincture and capsules.
- Suggests combining creatine with things that lower DHT, such as reishi mushroom, to enjoy the benefits of creatine while also benefiting from its immune and exercise properties.
- Uses wild Finnish Reishi in the evenings, noting it calms the system, increases REM sleep, leads to wild dreams, and helps work with the subconscious mind, also regulating the immune system.
- Shares thoughts on Reishi.
- States that Reishi is one of his favorite mushrooms and he takes it quite regularly, primarily for improving sleep, especially vivid and interesting dreams, and for relaxation.
- Reishi mushrooms are one of Siim Land's favorite mushrooms for boosting the immune system.
- Uses reishi mushroom quite frequently, taking 400 milligrams, as it helps with sleep architecture, lengthens overall sleep, and causes more vivid dreams.
- Siim Land enjoys taking Reishi almost every day for its adaptogenic properties.
- States that medicinal mushrooms like reishi, chaga, lion's mane, cordyceps, and turkey tail are potent adaptogens and anti-inflammatories that activate autophagy, and consumed as tinctures, powders, or teas, they will not break a fast.
- Lists medicinal mushrooms like Reishi as stimulating autophagy.
- Lists reishi as a medicinal mushroom that can help with stress.
- Lists reishi as a medicinal mushroom that can contribute to autophagy boosting.
- States that reishi mushroom extracts are shown to increase autophagy.
Dr. Rhonda Patrick · Reishi Mushroom · stopped
- Stopped using Four Sigmatic mushroom products because some of their powder products contained too much sugar and were raising her blood glucose.
RAL Summary
Members OnlyTier 4 for Healthy Aging
Tier 2 needs over 100 reviews with two thirds positive, but there are only 11 reviews, and the two reishi trials disagree, so the evidence supports tier 4. So it is graded Tier 4, lower than the rules alone gave.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 1 of the 7 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Immune system, Liver, Skin, Prostate, Metabolic system
Possible side effects: No major side effects reported; one reishi trial noted no signs of toxicity.
Supplement Facts
Nettle root extract 100 mg · African Cherry Tree Bark Extract 100 mg · Reishi Mushroom Fruit Extract 400 mg
| Nettle root extract | 100 mg | † |
| African Cherry Tree Bark Extract | 100 mg | † |
| Reishi Mushroom Fruit Extract | 400 mg | † |
| Magnolia Tree Bark Extract | 200 mg | † |
Other ingredients: Cellulose, Rice Husk, Rice Extract Blend.
Label source: NIH label database · Report a label change
Show entire label
More healthy aging products
Members OnlyThe highest ranked for the same goal
Read more
Our articles on this subject
- Healthy Aging Tips: A Science-Backed Guide to Living Better for LongerArticle · Mar 17, 2026
- NAD Anti-Aging Supplements: Benefits, Evidence, and How to ChooseArticle · Jun 15, 2026
Graded November 11, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
Privacy policyConsumer health dataAffiliate disclosureTermsDo Not Sell or Share My Personal InformationCookie settings