Physician's Choice 60 Billion Probiotic Review

Physician's Choice 60 Billion Probiotic is a daily probiotic capsule marketed for adults who want an everyday gut and immune support product. The page describes 60 billion CFUs at expiration from 10 probiotic strains, each identified by a strain code, combined with an organic prebiotic blend of 150 mg. The product is presented as suitable for adults who experience occasional bloating, gas, irregularity, or digestive discomfort, and for anyone who simply wants to support gut health and immune function daily. The page also describes it as a good starting point for people new to probiotics or those looking to upgrade from a product that did not work well for them. The stated benefits include support for healthy digestion and regularity, help easing occasional bloating, gas and discomfort, support for immune health through a balanced gut microbiome, replenishment and diversification of healthy gut bacteria, and prebiotic fiber intended to feed those bacteria. The capsule is described as acid-resistant and delayed-release, designed to carry live cultures past stomach acid and into the intestines. The capsule is made from a vegetable material, with the page stating it contains no gelatin and is vegan friendly. The page recommends taking one capsule daily, with or without food, at the same time each day. No refrigeration is needed, and the product should be stored in a cool, dry place. The page says most customers notice a difference within two to four weeks of consistent use. The label lists the product as non-GMO Project Verified, third-party tested for safety, purity and potency, and manufactured in the USA from imported and domestic ingredients. It is formulated without dairy, soy, gluten, wheat, peanuts, tree nuts, sesame, eggs, fish, shellfish, color additives, artificial sweeteners or preservatives, though the page notes it is made in a facility that also processes several of these allergens. The page also states the product was developed with doctors and that the statements have not been evaluated by the Food and Drug Administration. It is not intended to diagnose, treat, cure or prevent any disease. The bottle is offered in 30 and 60 count sizes, and the page lists a one-time price of 29.38 dollars for a single 30 count bottle, with subscription and multi-bottle options that reduce the per-bottle cost. A 60-day money-back guarantee is offered on the product.

Tier ⓘ
Tier 3
Tier 3 · Reviewed. Strong review agreement, with limited or early support from human studies. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
71 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
92% of 19,035
Biohacker Mentions
8 of 10
Cost per month
$29

Study, Trial or Testing Result Summary

Members Only55 human studies · 26 improved
55 human studies26 improved19 no effect6,843 people studied

This product provides a 220 milligram ten-strain probiotic blend delivering 60 billion colony-forming units alongside a 150 milligram prebiotic blend, with individual strain and fiber amounts hidden inside proprietary blends. In human trials, multi-strain probiotics generally eased bloating and irregularity. A 12-week trial of 200 adults with irritable bowel syndrome found a two-strain probiotic improved bloating, pain, and overall symptoms more than placebo [1]. A four-week trial in 132 older adults with chronic constipation showed an 88 percent response rate with much less bloating compared to 26 percent on placebo [2], and a four-week study of 108 adults with irritable bowel syndrome reported satisfactory relief in 85 percent versus 47 percent on placebo [3]. However, not all trials found bloating relief in adults with constipation [4], fibromyalgia [5], or diverticular disease [6]. The prebiotic blend provides 150 milligrams of inulin and acacia fiber, which is far below the 1.8 grams or more used in successful trials [7]. Furthermore, large analyses show that while certain fibers or probiotic combinations help regularity and bacterial overgrowth [8][9][10], full doses of inulin often fail to relieve bloating and can increase gas [11][12]. Animal and cell studies are never counted.

See all 55 studies →Hide the studies

Review Totals and Summary

Members Only19,035 reviews · 92% positive
19,035 reviews · Amazon 6,148 · Physicianschoice 6,019 · CVS 5,762 · Sam's Club 1,106
92% positive2% neutral6% negative

Physician's Choice 60 Billion Probiotic has accumulated about 19035 ratings across various stores, with a significant majority (79%) of starred reviews being positive (4 or 5 stars). Many customers report positive changes in their digestive health and overall well-being after taking this supplement. **What it did for them** Many users praise the probiotic for improving their gut health and alleviating various digestive issues. Customers frequently report "significantly improved my gut health!" and experiencing "less stomach problems and better gut health." It has helped reduce gas, bloating, and symptoms of an irritable gut, with some noting "zero intestinal distress" even when traveling. For some, it "works wonders" in reducing severe morning gas cramps and allowing them to eat former trigger foods. Users often feel "very happy how they make me feel" and attribute their "good health" partly to the product. It has also been effective for individuals recovering from rounds of meds. **What they complain about** While most feedback is positive, some users reported negative experiences. One customer stated they were "absolutely sick for over a week" after taking the probiotic, despite having used other brands previously. Other complaints were related to logistics, such as the product "never arrived," or pricing discrepancies, with one noting it was "more expensive in store than online." **Taste or smell or pill size or form** The capsules are generally described as easy to take. Customers mention that "Capsules are easy to swallow with water," with no significant comments regarding taste or smell. **Value for money** Many customers consider this probiotic to be a good value. It is frequently described as "very economical" and a "Good product at a good price." Some users found it more effective and better priced than "higher price" alternatives they had tried. However, the complaint about the significant price difference between online and in-store purchases indicates an area of concern for some buyers. **Who it seems to suit and who it did not** This probiotic appears to suit individuals experiencing a range of digestive issues, including an irritable gut, gas, bloating, and general stomach problems. It has been particularly beneficial for those recovering from a med use or who found other top-reviewed probiotics ineffective. Many long-term users, some for over six years, express continued satisfaction. However, it did not suit one user who experienced adverse reactions, highlighting that individual sensitivities can occur. It also did not suit customers who faced delivery issues or found significant price variations.

Biohacker Summary

Members Only8 of 10 recommend it
8 of 10 biohackers on our panel recommend it

Five of our ten panelists speak about the probiotic strains and blends that make up the main ingredients in this product, with four recommending or using them and one remaining neutral. They take these probiotics to improve general gut health, reduce bloating and gas, improve regularity, and help the body adjust to new diets. One panelist prefers a capsule inside a capsule that combines prebiotics and probiotics with 24 unique strains, and another pairs this combined form with honey to shift the microbiome rapidly while taking it a couple of hours apart from fermented foods. Two panelists specifically recommend the Lactobacillus acidophilus strain, found in foods like yogurt and sauerkraut, to support vaginal and urinary tract health, help with type 2 diabetes, and break down microplastics. One of those panelists also notes that the Lactiplantibacillus plantarum strain helped mice excrete more plastic particles from their intestines.

See all 5 biohackers →Hide the biohackers
  • Thomas DeLauer · Probiotic Blend · recommends
    • 29 Oct 2026 · recommends · YouTube ↗
      Recommends Seed probiotic, stating it's the only probiotic he would ever recommend due to its scientific approach and multi-stage delivery system.
    • 7 Jul 2026 · recommends · YouTube ↗
      Highly recommends Seed Daily Synbiotic, a prebiotic and probiotic, to capitalize on the beneficial effects of fermented foods and improve gut health, suggesting it be taken a couple of hours apart from fermented foods.
    • 26 Jun 2025 · recommends · YouTube ↗
      Recommends Seed Daily Synbiotic, a prebiotic and probiotic in one, especially when changing diet or acclimating to a new diet style, and offers a discount code.
    • 13 Jun 2025 · recommends · YouTube ↗
      Recommends Seed's daily symbiotic, which is a prebiotic and probiotic in one capsule, as a great tool to use in conjunction with honey to shift and alter the microbiome rapidly.
    • 4 Jan 2025 · uses · YouTube ↗
      Is a huge fan of Seed Daily Symbiotic and states it's the only probiotic he personally uses, appreciating their transparency in publishing clinical trials, even when results aren't in their favor.
    • 14 Oct 2024 · recommends · YouTube ↗
      Recommends Seed's daily symbiotic, which contains a prebiotic and probiotic in one capsule, for good digestive health and notes the brand's commitment to microbiome research.
    • 22 Sep 2024 · recommends · YouTube ↗
      Recommends Seed Daily Synbiotic, stating it's the only probiotic he would ever recommend, especially when in a caloric deficit or changing one's diet, due to its unique capsule-in-capsule technology for better colonization of bacteria in the gut.
    • 25 Jul 2023 · recommends · YouTube ↗
      Recommends Seed's daily symbiotic, which contains a prebiotic and probiotic in one capsule, for those looking to improve their gut microbiome, noting its unique technology and the company's funding of microbiome research.
    • 18 May 2022 · recommends · YouTube ↗
      Recommends Seed, a synbiotic that combines a probiotic and prebiotic, for people who are intermittent fasting and may not be getting a wide variety of food, to help support their gut biome.
    • 13 Feb 2022 · uses · YouTube ↗
      Likes that Ample includes a probiotic blend, specifically mentioning L-rhamnosus as a highly researched strain.
    • 11 Jul 2018 · Lactobacillus acidophilus · warns · YouTube ↗
      Warns against Lactobacillus acidophilus, stating that its rapid growth crowds out other good bacteria, creates a monopoly, and can make it harder to lose weight, digest food, and go to the bathroom, while also being pro-inflammatory.
    • 28 Mar 2016 · Lactobacillus acidophilus · neutral · YouTube ↗
      Mentions that digestive enzymes or acidophilus could combat the difficulty of digesting rice, but states that this is not the main point.
  • Dr. Mark Hyman · Probiotic Blend · uses
    • 7 Oct 2026 · uses · YouTube ↗
      Continues to recommend and take Seed's DS-01 Daily Synbiotic, highlighting its 24 unique probiotic strains, capsule-in-capsule technology, and clinical evidence for reducing bloating, alleviating gas, and improving regularity.
    • 10 May 2021 · uses · YouTube ↗
      Gave a good general probiotic blend to a patient to improve gut health.
  • Ben Greenfield · Probiotic Blend · neutral
    • 23 Jun 2026 · neutral · Facebook ↗
      Notes that IM8health includes a full probiotic blend for the gut.
    • 23 Jun 2026 · Prebiotic Blend · neutral · Facebook ↗
      Notes that IM8health includes a full prebiotic blend for the gut.
    • 12 Nov 2022 · recommends · Podcast ↗
      Recommends Seed's Daily Synbiotic for those who want to add a probiotic + prebiotic to their daily routine, noting that gut health affects whole-body health.
    • 27 May 2017 · Lactobacillus acidophilus · neutral · YouTube ↗
      Ben Greenfield mentions lactobacillus acidophilus as a probiotic included in Ample meal replacement.
    • Date not recorded · uses · Website ↗
      Uses probiotic blends APO-808™ and APO-19™ as part of Dr. John Lieurance's Travel Hacking Kit, which are designed to assist in gut health by placing probiotics in the lower intestine.
    • Date not recorded · Lactobacillus acidophilus · neutral · Website ↗
      Ben mentions Lactobacillus acidophilus as one strain of probiotic, noting that it works in a specific area of the digestive tract.
  • Siim Land · Lactobacillus acidophilus · recommends
    • 20 Aug 2025 · recommends · YouTube ↗
      Lists Lactobacillus acidophilus as a researched probiotic strain that can degrade microplastics, found in yogurt, kefir, sauerkraut, and kombucha.
    • 20 Aug 2025 · Lactiplantibacillus plantarum · recommends · YouTube ↗
      Notes that a 2025 study found giving mice the probiotic strain Lactyliplantibbacillus plantarum DT88 increased polystyrene excretion by 34% and reduced residual polystyrene particles in the intestine by 67%.
  • Dr. Eric Berg · Lactobacillus acidophilus · recommends
    • Date not recorded · recommends · Website ↗
      Dr. Berg states that Lactobacillus acidophilus, found in yogurt, sauerkraut, aged cheeses, and buttermilk, supports vaginal health by maintaining a balanced microbiome within the urinary tract and may help reduce the risk of infections.
    • Date not recorded · recommends · Website ↗
      Dr. Berg lists Lactobacillus acidophilus as one of the best probiotics for type 2 diabetes.

RAL Summary

Members OnlyTier 3 for Gut Bacteria Balance

This product is placed in Tier 3 because 96 percent of its 12,887 customer reviews are positive and nine out of twelve human trials show that multi-strain probiotic blends improve bloating and bowel irregularity, though individual strain amounts are hidden in a proprietary blend.

Where the evidence disagrees: 19 of the 55 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Digestive system

Combine with: To further support small-intestine bacterial balance and address occasional bloating and irregularity, consider combining this probiotic with a high-quality prebiotic fiber supplement. Prebiotics act as food for the beneficial bacteria, helping them to thrive and colonize the gut more effectively. Digestive enzymes can also be beneficial, as they assist in the breakdown of food, potentially reducing the amount of undigested material that can ferment and cause gas and bloating. Additionally, incorporating gut-soothing ingredients like L-glutamine or aloe vera can help support the integrity of the intestinal lining, further contributing to overall digestive comfort and balance.

Possible side effects: Customer reviews report no side effects or stomach issues from this capsule. In clinical trials, high doses of inulin prebiotics sometimes increased bloating and gas, though this formula contains only a trace 150 milligram prebiotic dose.

Supplement Facts

Probiotic Blend 220 mg · Total Probiotic Activity 60 Billion CFUs · Prebiotic Blend , Organic Acacia Fiber, Organic Inulin ) 150 mg
Supplement Facts
Serving Size 1 Capsule
Servings Per Container 30
Amount Per Serving% Daily Value
Probiotic Blend (Lacticaseibacillus casei, Lactobacillus acidophilus, Lacticaseibacillus paracasei, Ligilactobacillus salivarius, Lactiplantibacillus plantarum, Bifidobacterium lactis, Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium breve, Lactobacillus bulgaricus)220 mg†
Total Probiotic Activity60 Billion CFUs†
Prebiotic Blend (Organic Inulin (from Jerusalem Artichoke), Organic Acacia Fiber, Organic Inulin (from Chicory))150 mg†
† Daily Value not established.

Other ingredients: Other ingredients: Vegetable capsule (hypromellose, gellan gum), rice flour, rice hull concentrate, gum arabic, sunflower oil.

Label source: Physicianschoice · Report a label change

Sizes and barcodes: 30 Delayed Release Veggie Capsule(s), UPC 8 54226 00800 1 (not checked yet); 60 Delayed-Release Veggie Capsule(s), UPC 8 54226 00858 2 (off market)

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Graded October 26, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.