Physician's Choice 60 Billion Probiotic Review
Physician's Choice 60 Billion Probiotic is a daily probiotic capsule marketed for adults who want an everyday gut and immune support product. The page describes 60 billion CFUs at expiration from 10 probiotic strains, each identified by a strain code, combined with an organic prebiotic blend of 150 mg. The product is presented as suitable for adults who experience occasional bloating, gas, irregularity, or digestive discomfort, and for anyone who simply wants to support gut health and immune function daily. The page also describes it as a good starting point for people new to probiotics or those looking to upgrade from a product that did not work well for them. The stated benefits include support for healthy digestion and regularity, help easing occasional bloating, gas and discomfort, support for immune health through a balanced gut microbiome, replenishment and diversification of healthy gut bacteria, and prebiotic fiber intended to feed those bacteria. The capsule is described as acid-resistant and delayed-release, designed to carry live cultures past stomach acid and into the intestines. The capsule is made from a vegetable material, with the page stating it contains no gelatin and is vegan friendly. The page recommends taking one capsule daily, with or without food, at the same time each day. No refrigeration is needed, and the product should be stored in a cool, dry place. The page says most customers notice a difference within two to four weeks of consistent use. The label lists the product as non-GMO Project Verified, third-party tested for safety, purity and potency, and manufactured in the USA from imported and domestic ingredients. It is formulated without dairy, soy, gluten, wheat, peanuts, tree nuts, sesame, eggs, fish, shellfish, color additives, artificial sweeteners or preservatives, though the page notes it is made in a facility that also processes several of these allergens. The page also states the product was developed with doctors and that the statements have not been evaluated by the Food and Drug Administration. It is not intended to diagnose, treat, cure or prevent any disease. The bottle is offered in 30 and 60 count sizes, and the page lists a one-time price of 29.38 dollars for a single 30 count bottle, with subscription and multi-bottle options that reduce the per-bottle cost. A 60-day money-back guarantee is offered on the product.
We don’t sell supplements. We help you make decisions and get the best price.
Lowest prices
We may earn a commission from some store links. How we choose.
Lowest cost per month first, in stock, at 1 capsule a day. Checked Nov 8.
- Physician's ChoiceLowest$47.05 a bottle$47.05/moBuy at Physician's Choice (opens in a new tab)
Products with nearly the same formula (Matched on the main ingredients)
Study, Trial or Testing Result Summary
Members Only55 human studies · 26 improved
This product provides a 220 milligram ten-strain probiotic blend delivering 60 billion colony-forming units alongside a 150 milligram prebiotic blend, with individual strain and fiber amounts hidden inside proprietary blends. In human trials, multi-strain probiotics generally eased bloating and irregularity. A 12-week trial of 200 adults with irritable bowel syndrome found a two-strain probiotic improved bloating, pain, and overall symptoms more than placebo [1]. A four-week trial in 132 older adults with chronic constipation showed an 88 percent response rate with much less bloating compared to 26 percent on placebo [2], and a four-week study of 108 adults with irritable bowel syndrome reported satisfactory relief in 85 percent versus 47 percent on placebo [3]. However, not all trials found bloating relief in adults with constipation [4], fibromyalgia [5], or diverticular disease [6]. The prebiotic blend provides 150 milligrams of inulin and acacia fiber, which is far below the 1.8 grams or more used in successful trials [7]. Furthermore, large analyses show that while certain fibers or probiotic combinations help regularity and bacterial overgrowth [8][9][10], full doses of inulin often fail to relieve bloating and can increase gas [11][12]. Animal and cell studies are never counted.
See all 55 studies →Hide the studies
- In an analysis of 729 adults with irritable bowel syndrome or functional bowel disorders, prebiotics did not improve overall bloating or abdominal pain compared to placebo, though doses of 6 grams or less daily and non-inulin prebiotics reduced flatulence while inulin worsened it.Prebiotics in irritable bowel syndrome and other functional bowel disorders in adults: a systematic review and meta-anal…
- Across 5 trials of 252 people with chronic constipation, taking inulin improved stool frequency, consistency, hardness, and transit time, but did not improve bloating or pain.Effectiveness of inulin intake on indicators of chronic constipation; a meta-analysis of controlled randomized clinical …
- In a review of 17 studies in patients with inflammatory bowel disease, fructooligosaccharide kestose helped induce remission in ulcerative colitis, whereas oligofructose-enriched inulin did not improve remission and increased bloating and flatulence.Prebiotics for Induction and Maintenance of Remission in Inflammatory Bowel Disease: Systematic Review and Meta-Analysis…
- Across 43 trials in adults with irritable bowel syndrome or chronic constipation, synbiotics appeared beneficial for symptom relief while data on prebiotics alone were too sparse to draw conclusions.Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: syst…
- In an analysis of 10 studies in children with constipation, non-polyethylene glycol laxatives including lactulose and fibers were less effective for resolving fecal impaction and less accepted than polyethylene glycol.Efficacy and complications of polyethylene glycols for treatment of constipation in children: a meta-analysis.
- In a review of 12 studies totaling 974 adult cancer patients and survivors, prebiotic interventions showed minimal evidence for improving gastrointestinal symptoms such as gas, bloating, or diarrhea.The Use of Prebiotic and Probiotic Interventions for Treating Gastrointestinal and Psychosocial Health Symptoms in Cance…
- In a review of 41 trials lasting at least 4 weeks for chronic constipation, yogurt with galacto-oligosaccharide and fiber supplements had moderate evidence for effectiveness, while inulin, fructo-oligosaccharide, and polydextrose had insufficient evidence.Efficacy and Safety of Over-the-Counter Therapies for Chronic Constipation: An Updated Systematic Review.
- In 721 healthy volunteers studied across three winter seasons, taking synbiotic formulas containing fructooligosaccharides or galactooligosaccharides reduced bloating and improved intestinal regularity compared to placebo.A new chance of preventing winter diseases by the administration of synbiotic formulations.
- In 200 adults with non-constipated irritable bowel syndrome, a two-strain probiotic taken for 84 days improved overall symptoms, pain and bloating more than placebo (19.3% vs 8.9% responders at day 28), though gut bacteria overall did not differ between groups.Probiotic Blend of Lactobacillus acidophilus LA-5 and Bifidobacterium animalis ssp. Lactis BB-12 in Non-constipated Irri…
- In 189 adults with fecal incontinence taking 16 grams daily of dietary fiber for 38 days, bloating and gas did not differ from placebo, aside from a greater feeling of fullness in the psyllium group.Symptoms associated with dietary fiber supplementation over time in individuals with fecal incontinence.
- In 179 patients with small intestinal bacterial overgrowth, adding prebiotics, probiotics, and herbal supplements to standard a med and diet therapy increased clinical remission rates, especially for methane-dominant overgrowth, without significantly changing gas levels.Read the study on PubMed (38613116) →
- In 159 healthy travelers taking a galacto-oligosaccharide prebiotic mixture for at least 3 weeks, the incidence and duration of travelers' diarrhea and abdominal pain decreased compared with placebo.A double-blind, placebo-controlled, randomized human study assessing the capacity of a novel galacto-oligosaccharide mix…
- In 156 adults with constipation and bloating, a five-strain probiotic taken for 2 weeks did not reduce bloating more than placebo, though a post-hoc analysis showed less flatulence.The effect of a probiotic blend on gastrointestinal symptoms in constipated patients: a double blind, randomised, placeb…
- In 143 adults with symptomatic diverticular disease, a liquid probiotic for 3 months did not reduce abdominal pain more than placebo or bloating frequency, but did reduce constipation, diarrhea, mucus discharge and back pain.A randomized double-blind placebo-controlled trial of a multi-strain probiotic in treatment of symptomatic uncomplicated…
- In 132 middle-aged and older adults with chronic constipation, a multi-strain probiotic for 28 days markedly reduced bloating (0.70 vs 2.60 score) and 88% responded versus 26% on placebo.A multi-strain probiotic formulation alleviates chronic constipation in middle-aged and older adults: A randomized, doub…
- In 120 healthy adult women taking 30 grams of gum arabic daily for 6 weeks, body mass index and body fat percentage decreased, though mild abdominal bloating and diarrhea occurred during the first week.Effects of Gum Arabic ingestion on body mass index and body fat percentage in healthy adult females: two-arm randomized,…
- In 110 people with fibromyalgia, VSL#3 for 12 weeks did not improve abdominal pain, bloating or gas more than placebo.The Probiotic VSL#3® Does Not Seem to Be Efficacious for the Treatment of Gastrointestinal Symptomatology of Patients wi…
- In 108 adults with irritable bowel syndrome and bloating, a multi-strain probiotic twice daily for 4 weeks gave satisfactory relief in 85% versus 47% on placebo and reduced bloating and pain more.Therapeutic effects, tolerability and safety of a multi-strain probiotic in Iranian adults with irritable bowel syndrome…
- In 84 healthy adults taking 5 to 20 grams daily of inulin-type fructans for 2 weeks, doses up to 10 grams were well tolerated without significant changes in bloating or digestive symptoms, while 20 grams daily of Fibruline Instant mildly increased overall digestive symptoms.Digestive tolerance of inulin-type fructans: a double-blind, placebo-controlled, cross-over, dose-ranging, randomized st…
- In 83 adults with digestive symptoms taking 2.75 g of a galactooligosaccharide prebiotic mixture daily for 2 weeks, bloating, flatulence, and abdominal pain decreased compared to placebo.Effect of a prebiotic galactooligosaccharide mixture (B-GOS®) on gastrointestinal symptoms in adults selected from a gen…
- In 71 children with irritable bowel syndrome who took 1,800 milligrams of inulin daily for 4 weeks, 12.5% achieved full recovery from symptoms with inulin alone compared to 39.1% when combined with a probiotic, which also significantly improved post-meal bloating and constipation.Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A randomized contro…
- In 71 patients with human immunodeficiency virus taking a fiber-based prebiotic and probiotic blend for 6 months, immune cell ratios improved, while mild digestive side effects like bloating and flatulence occurred at a similar rate to placebo.Probiotic effects on immunity and microbiome in HIV-1 discordant patients.
- In 61 adults with or at risk of metabolic syndrome who took 20 grams of Gum Arabic daily for 12 weeks, self-perceived bloating, bowel movement quality, blood pressure, and fasting blood sugar all improved compared to placebo.The Effect of Gum Arabic (Acacia Senegal) on Cardiovascular Risk Factors and Gastrointestinal Symptoms in Adults at Risk…
- In 60 adults with unexplained digestive discomfort, a three-strain Bacillus probiotic improved bloating, belching, sour taste and total dyspepsia scores more than placebo by day 30, with no adverse events.A prospective, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of…
- In 60 patients with diarrhea-predominant irritable bowel syndrome taking a blend containing xylo-oligosaccharides for 28 days, 87% achieved normal stools along with reduced bloating and abdominal pain compared to 0% on placebo.Efficacy and safety of Gelsectan for diarrhoea-predominant irritable bowel syndrome: A randomised, crossover clinical tr…
- In 29 adults with irritable bowel syndrome and 29 healthy adults given a single 40-gram dose of inulin, colonic gas and breath hydrogen increased and 13 of 29 patients experienced clinically important symptom responses.Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in In…
- In healthy adults taking 8.1 g of soluble chicory extract (containing 5 g of inulin) daily for 4 weeks, there were no differences in bloating, flatulence, or bowel habits compared to placebo, though a higher 14 g dose for 6 days slightly increased abdominal discomfort.Gastrointestinal tolerance to an inulin-rich soluble roasted chicory extract after consumption in healthy subjects.
- In 51 adults with irritable bowel syndrome and constipation, adding a supplement of inulin, choline, and silymarin to a constipation diet for 8 weeks reduced abdominal pain and bloating severity compared with diet alone, though weekly stool count did not significantly differ between groups.Inulin, Choline and Silymarin in the Treatment of Irritable Bowel Syndrome with Constipation-Randomized Case-Control Stu…
- In 50 patients with nonalcoholic steatohepatitis taking a synbiotic of guar gum, inulin, and Lactobacillus reuteri for 3 months, liver fat and weight decreased, while intestinal permeability did not improve.Beneficial Effect of Synbiotic Supplementation on Hepatic Steatosis and Anthropometric Parameters, But Not on Gut Permea…
- In 50 adults with constipation-predominant irritable bowel syndrome taking two daily jelly drinks with inulin, curcumin, and vitamin B6 for 2 weeks, stool frequency, stool consistency, bloating, and abdominal pain improved.[Dry jelly concentrate with vitamins and dietary fiber in patients with IBS with constipation: a comparative controlled …
- In 49 patients with constipation-predominant irritable bowel syndrome taking 4 grams of inulin with menthol and vitamin B6 daily for 2 weeks, bloating, abdominal pain, and bowel movement frequency improved, though 10 of 25 patients experienced heartburn.[Using a multicomponent functional food in IBS patients with constipation a comparative controlled study].
- In 48 healthy adults given a single 20-gram or 40-gram dose of acacia gum at breakfast, the 40-gram dose increased satiety but also caused more bloating, flatulence, and stomach rumbling than control.Acacia Gum Is Well Tolerated While Increasing Satiety and Lowering Peak Blood Glucose Response in Healthy Human Subjects…
- In 40 patients with small intestinal bacterial overgrowth treated for 6 months with monthly rifaximin followed by 7 days of either short-chain fructo-oligosaccharides or a probiotic, the prebiotic group improved in 4 out of 6 subjective gastrointestinal symptoms.Read the study on PubMed (23244247) →
- In 40 patients with constipation-predominant irritable bowel syndrome, drinking 220 milliliters daily of a pasteurized kombucha beverage enriched with 2.53 grams of inulin for 10 days improved stool frequency, stool form, and feelings of incomplete bowel emptying compared to water, with no difference in bloating.[Efficacy of newly developed kombucha-based specialized food product for treatment of constipation-predominant irritable…
- In 38 adults with functional constipation or diarrhea, a multi-strain probiotic for 8 weeks reduced bloating severity and its effect on quality of life compared with placebo.Therapeutic Modulation of the Gut Microbiome by Supplementation with Probiotics (SCI Microbiome Mix) in Adults with Func…
- In 37 adults with type 2 diabetes who could not tolerate a med, a multi-strain probiotic taken for 12 weeks in a crossover trial reduced nausea, abdominal bloating and pain, and improved how well they tolerated a med compared with placebo.Read the study on PubMed (37812890) →
- In 32 healthy adults taking 10 grams daily of globe artichoke inulin for 3 weeks, beneficial gut bacteria increased compared with placebo, though mild and moderate bloating also increased.A double-blind, placebo-controlled, cross-over study to establish the bifidogenic effect of a very-long-chain inulin ext…
- In 30 healthy adults taking an acute 25 gram challenge of inulin, co-administration of fructanase reduced bloating, abdominal pain, burping, and flatulence over 24 hours compared with placebo.Oral Fructanase Administration Reduces Gastrointestinal Symptom Severity after Acute Inulin Challenge in Healthy Adults.
- In 29 healthy adults taking 5 to 7.5 g of agave inulin daily for 21 days, daily bowel movements and stool softness improved, though mild bloating, gas, and stomach rumbling increased compared to placebo.Gastrointestinal tolerance and utilization of agave inulin by healthy adults.
- In 26 healthy adults, single breakfast challenges of 5 to 10 grams of native inulin or oligofructose mildly increased flatulence and bloating, with 10 grams of oligofructose substantially increasing gastrointestinal symptoms compared to placebo.Gastrointestinal tolerance of chicory inulin products.
- In 23 children with irritable bowel syndrome given meals containing up to 19 grams of fructans for 72 hours, fructans caused more frequent abdominal pain, more severe bloating and flatulence, and greater breath hydrogen production compared to maltodextrin.Fructans Exacerbate Symptoms in a Subset of Children With Irritable Bowel Syndrome.
- In 22 adult women consuming 10 grams of isolated fermentable fibers at dinner and 10 grams the next morning, the fibers increased gastrointestinal symptoms—with oligofructose causing the most bloating, flatulence, and breath hydrogen—compared with a control bar.Fermentable fibers do not affect satiety or food intake by women who do not practice restrained eating.
- In 13 healthy volunteers taking 9.4 grams of arabinoxylan-oligosaccharide twice daily for 2 days, colonic fermentation and post-meal bloating scores increased compared to placebo without altering transit time.The effect of arabinoxylooligosaccharides on gastric sensory-motor function and nutrient tolerance in man.
- In 12 healthy people given a single dose of 1.25 to 40 grams of inulin or glucose, inulin caused a dose-dependent increase in intestinal hydrogen gas production.The safety and sensitivity of a telemetric capsule to monitor gastrointestinal hydrogen production in vivo in healthy su…
- In healthy adults taking 8 g of xylo-oligosaccharides daily for 21 days, daily bowel movements and beneficial gut bacteria increased without worsening bloating, gas, or abdominal pain compared to placebo.Xylo-oligosaccharides alone or in synbiotic combination with Bifidobacterium animalis subsp. lactis induce bifidogenesis…
- In 45 healthy adults, an acute intake of yogurt with 3% inulin caused no bloating, whereas 7% and 13% inulin significantly increased bloating and flatulence compared to yogurt without inulin.Sensory Acceptance, Appetite Control and Gastrointestinal Tolerance of Yogurts Containing Coffee-Cascara Extract and Inu…
- People fed an enteral formula fortified with a blend of fructo-oligosaccharides, inulin, gum acacia, and pea fiber had higher fecal short-chain fatty acids compared to a fiber-free formula.Estimation and interpretation of fermentation in the gut: coupling results from a 24 h batch in vitro system with fecal …
- In hemodialysis patients taking partially hydrolyzed guar gum for 4 weeks, fecal butyric acid increased three-fold, whereas those taking a synbiotic blend saw improvements in stool form and abdominal bloating.Synbiotics Improved Stool Form via Changes in the Microbiota and Short-Chain Fatty Acids in Hemodialysis Patients.
- In 134 adults with irritable bowel syndrome followed over time while taking a daily synbiotic supplement (out of 612 total participants studied), probiotic abundance increased and gut microbial features changed.Alterations in Gut Microbiome Composition and Function in Irritable Bowel Syndrome and Increased Probiotic Abundance wit…
- In 112 pregnant women with clinical hypothyroidism and small intestinal bacterial overgrowth (from a broader cohort of 441 pregnant women), taking probiotics combined with prebiotics for 21 days reduced breath hydrogen and methane levels, constipation, and inflammatory markers compared with baseline.Efficacy evaluation of probiotics combined with prebiotics in patients with clinical hypothyroidism complicated with sma…
- In an open-label study of 188 adults with functional gastrointestinal symptoms, 85.1% reported overall gut well-being improvement after 30 days of a 5-strain probiotic, with no safety signals, though without a placebo group.An Open-label, Multicenter Study to Assess the Efficacy and Safety of a Novel Probiotic Blend in Patients With Functiona…
- In a 4-week open-label study of 39 airline pilots with chronic gastritis, taking a Saccharomyces boulardii and Enterococcus faecium probiotic twice daily reduced stomach pain and bloating more than no treatment, at both the low and high doses tested.Probiotic Supplementation With Saccharomyces boulardii and Enterococcus faecium Improves Gastric Pain and Bloating in Ai…
- In 32 pregnant women with subclinical hypothyroidism and small intestinal bacterial overgrowth, taking probiotics combined with prebiotics for 21 days reduced breath methane and hydrogen, lowered C-reactive protein, and improved diarrhea, indigestion, and constipation compared to baseline.Probiotics and Prebiotics in Subclinical Hypothyroidism of Pregnancy with Small Intestinal Bacterial Overgrowth.
- In 20 older adults taking 15 g of yeast mannans daily for 2 weeks, stool frequency increased in those with low baseline bowel movements, though mild cramping and bloating slightly increased.Yeast mannans promote laxation and specifically modulate microbiota composition in older adults: An open-label pilot stu…
- In a case series of 4 children and teenagers with severe recessive dystrophic epidermolysis bullosa, 3 who completed 12 weeks of a daily multistrain liquid probiotic (1 mL per kg) reported less abdominal pain, bloating, nausea and flatulence, firmer stools, and better appetite, and two could cut back or stop laxative gel; there was no placebo group.The impact of using a multistrain probiotic supplement on gastrointestinal function in children and adolescents with sev…
Review Totals and Summary
Members Only19,035 reviews · 92% positive
Physician's Choice 60 Billion Probiotic has accumulated about 19035 ratings across various stores, with a significant majority (79%) of starred reviews being positive (4 or 5 stars). Many customers report positive changes in their digestive health and overall well-being after taking this supplement. **What it did for them** Many users praise the probiotic for improving their gut health and alleviating various digestive issues. Customers frequently report "significantly improved my gut health!" and experiencing "less stomach problems and better gut health." It has helped reduce gas, bloating, and symptoms of an irritable gut, with some noting "zero intestinal distress" even when traveling. For some, it "works wonders" in reducing severe morning gas cramps and allowing them to eat former trigger foods. Users often feel "very happy how they make me feel" and attribute their "good health" partly to the product. It has also been effective for individuals recovering from rounds of meds. **What they complain about** While most feedback is positive, some users reported negative experiences. One customer stated they were "absolutely sick for over a week" after taking the probiotic, despite having used other brands previously. Other complaints were related to logistics, such as the product "never arrived," or pricing discrepancies, with one noting it was "more expensive in store than online." **Taste or smell or pill size or form** The capsules are generally described as easy to take. Customers mention that "Capsules are easy to swallow with water," with no significant comments regarding taste or smell. **Value for money** Many customers consider this probiotic to be a good value. It is frequently described as "very economical" and a "Good product at a good price." Some users found it more effective and better priced than "higher price" alternatives they had tried. However, the complaint about the significant price difference between online and in-store purchases indicates an area of concern for some buyers. **Who it seems to suit and who it did not** This probiotic appears to suit individuals experiencing a range of digestive issues, including an irritable gut, gas, bloating, and general stomach problems. It has been particularly beneficial for those recovering from a med use or who found other top-reviewed probiotics ineffective. Many long-term users, some for over six years, express continued satisfaction. However, it did not suit one user who experienced adverse reactions, highlighting that individual sensitivities can occur. It also did not suit customers who faced delivery issues or found significant price variations.
Biohacker Summary
Members Only8 of 10 recommend it
Five of our ten panelists speak about the probiotic strains and blends that make up the main ingredients in this product, with four recommending or using them and one remaining neutral. They take these probiotics to improve general gut health, reduce bloating and gas, improve regularity, and help the body adjust to new diets. One panelist prefers a capsule inside a capsule that combines prebiotics and probiotics with 24 unique strains, and another pairs this combined form with honey to shift the microbiome rapidly while taking it a couple of hours apart from fermented foods. Two panelists specifically recommend the Lactobacillus acidophilus strain, found in foods like yogurt and sauerkraut, to support vaginal and urinary tract health, help with type 2 diabetes, and break down microplastics. One of those panelists also notes that the Lactiplantibacillus plantarum strain helped mice excrete more plastic particles from their intestines.
See all 5 biohackers →Hide the biohackers
Thomas DeLauer · Probiotic Blend · recommends
- Recommends Seed probiotic, stating it's the only probiotic he would ever recommend due to its scientific approach and multi-stage delivery system.
- Highly recommends Seed Daily Synbiotic, a prebiotic and probiotic, to capitalize on the beneficial effects of fermented foods and improve gut health, suggesting it be taken a couple of hours apart from fermented foods.
- Recommends Seed Daily Synbiotic, a prebiotic and probiotic in one, especially when changing diet or acclimating to a new diet style, and offers a discount code.
- Recommends Seed's daily symbiotic, which is a prebiotic and probiotic in one capsule, as a great tool to use in conjunction with honey to shift and alter the microbiome rapidly.
- Is a huge fan of Seed Daily Symbiotic and states it's the only probiotic he personally uses, appreciating their transparency in publishing clinical trials, even when results aren't in their favor.
- Recommends Seed's daily symbiotic, which contains a prebiotic and probiotic in one capsule, for good digestive health and notes the brand's commitment to microbiome research.
- Recommends Seed Daily Synbiotic, stating it's the only probiotic he would ever recommend, especially when in a caloric deficit or changing one's diet, due to its unique capsule-in-capsule technology for better colonization of bacteria in the gut.
- Recommends Seed's daily symbiotic, which contains a prebiotic and probiotic in one capsule, for those looking to improve their gut microbiome, noting its unique technology and the company's funding of microbiome research.
- Recommends Seed, a synbiotic that combines a probiotic and prebiotic, for people who are intermittent fasting and may not be getting a wide variety of food, to help support their gut biome.
- Likes that Ample includes a probiotic blend, specifically mentioning L-rhamnosus as a highly researched strain.
- Warns against Lactobacillus acidophilus, stating that its rapid growth crowds out other good bacteria, creates a monopoly, and can make it harder to lose weight, digest food, and go to the bathroom, while also being pro-inflammatory.
- Mentions that digestive enzymes or acidophilus could combat the difficulty of digesting rice, but states that this is not the main point.
Dr. Mark Hyman · Probiotic Blend · uses
- Continues to recommend and take Seed's DS-01 Daily Synbiotic, highlighting its 24 unique probiotic strains, capsule-in-capsule technology, and clinical evidence for reducing bloating, alleviating gas, and improving regularity.
- Gave a good general probiotic blend to a patient to improve gut health.
Ben Greenfield · Probiotic Blend · neutral
- Notes that IM8health includes a full probiotic blend for the gut.
- Notes that IM8health includes a full prebiotic blend for the gut.
- Recommends Seed's Daily Synbiotic for those who want to add a probiotic + prebiotic to their daily routine, noting that gut health affects whole-body health.
- Ben Greenfield mentions lactobacillus acidophilus as a probiotic included in Ample meal replacement.
- Uses probiotic blends APO-808™ and APO-19™ as part of Dr. John Lieurance's Travel Hacking Kit, which are designed to assist in gut health by placing probiotics in the lower intestine.
- Ben mentions Lactobacillus acidophilus as one strain of probiotic, noting that it works in a specific area of the digestive tract.
Siim Land · Lactobacillus acidophilus · recommends
- Lists Lactobacillus acidophilus as a researched probiotic strain that can degrade microplastics, found in yogurt, kefir, sauerkraut, and kombucha.
- Notes that a 2025 study found giving mice the probiotic strain Lactyliplantibbacillus plantarum DT88 increased polystyrene excretion by 34% and reduced residual polystyrene particles in the intestine by 67%.
Dr. Eric Berg · Lactobacillus acidophilus · recommends
- Dr. Berg states that Lactobacillus acidophilus, found in yogurt, sauerkraut, aged cheeses, and buttermilk, supports vaginal health by maintaining a balanced microbiome within the urinary tract and may help reduce the risk of infections.
- Dr. Berg lists Lactobacillus acidophilus as one of the best probiotics for type 2 diabetes.
RAL Summary
Members OnlyTier 3 for Gut Bacteria Balance
This product is placed in Tier 3 because 96 percent of its 12,887 customer reviews are positive and nine out of twelve human trials show that multi-strain probiotic blends improve bloating and bowel irregularity, though individual strain amounts are hidden in a proprietary blend.
Where the evidence disagrees: 19 of the 55 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Digestive system
Combine with: To further support small-intestine bacterial balance and address occasional bloating and irregularity, consider combining this probiotic with a high-quality prebiotic fiber supplement. Prebiotics act as food for the beneficial bacteria, helping them to thrive and colonize the gut more effectively. Digestive enzymes can also be beneficial, as they assist in the breakdown of food, potentially reducing the amount of undigested material that can ferment and cause gas and bloating. Additionally, incorporating gut-soothing ingredients like L-glutamine or aloe vera can help support the integrity of the intestinal lining, further contributing to overall digestive comfort and balance.
Possible side effects: Customer reviews report no side effects or stomach issues from this capsule. In clinical trials, high doses of inulin prebiotics sometimes increased bloating and gas, though this formula contains only a trace 150 milligram prebiotic dose.
Supplement Facts
Probiotic Blend 220 mg · Total Probiotic Activity 60 Billion CFUs · Prebiotic Blend , Organic Acacia Fiber, Organic Inulin ) 150 mg
| Probiotic Blend (Lacticaseibacillus casei, Lactobacillus acidophilus, Lacticaseibacillus paracasei, Ligilactobacillus salivarius, Lactiplantibacillus plantarum, Bifidobacterium lactis, Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium breve, Lactobacillus bulgaricus) | 220 mg | † |
| Total Probiotic Activity | 60 Billion CFUs | † |
| Prebiotic Blend (Organic Inulin (from Jerusalem Artichoke), Organic Acacia Fiber, Organic Inulin (from Chicory)) | 150 mg | † |
Other ingredients: Other ingredients: Vegetable capsule (hypromellose, gellan gum), rice flour, rice hull concentrate, gum arabic, sunflower oil.
Label source: Physicianschoice · Report a label change
Sizes and barcodes: 30 Delayed Release Veggie Capsule(s), UPC 8 54226 00800 1 (not checked yet); 60 Delayed-Release Veggie Capsule(s), UPC 8 54226 00858 2 (off market)
Show entire label
More gut bacteria balance products
Members OnlyThe highest ranked for the same goal
Read more
Our articles on this subject
- Probiotics for Gut Health: The Complete GuideArticle · Mar 17, 2026
- Best Probiotic for Bloating: The Strains With Human Trials, and How to Choose OneArticle · Oct 27, 2026
Graded October 26, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
Privacy policyConsumer health dataAffiliate disclosureTermsDo Not Sell or Share My Personal InformationCookie settings

