PureLean Satiety Review

Yeast hydrolysate is at a full dose here and has the most direct support for men. In obese men and women taking 1 gram daily for 10 weeks, body weight, body fat and belly fat fell more than with placebo, without loss of lean tissue ^[1]. In 30 obese women, half a gram daily for 8 weeks lowered weight and body fat and reduced calorie intake, though men were not studied ^[2]. Both trials were small and short. Chromium is also at a full dose, but its effect is small. Reviews of trials found about 0.5 to 1.1 kilograms of extra weight loss, of uncertain real-world value and partly low-quality evidence ^[3][4][5]. In people with type 2 diabetes it did not change weight or body size ^[6][7], and a high dose for 24 weeks gave no extra weight loss ^[8]. Ashwagandha here comes to 250 milligrams a day at two servings, less than the 600 milligrams used in most weight trials. A large review of 20 trials found no effect on weight or body fat ^[9], and another found no clear fat loss with resistance training ^[10]. Some single trials found weight or fat loss ^[11][12], while others found no change ^[13][14]. Animal and cell studies are never counted.

Chromium, the main ingredient, drew comments from seven of the ten panelists, and the group leans toward recommending it: four recommend it and three are neutral. Those who recommend it point to insulin resistance, blood sugar control and better body composition, with one saying chromium picolinate works at a couple hundred micrograms and another saying he uses it in his practice. The neutral voices call it a mild effect on blood glucose or a secondary ingredient in blood sugar products, and one only notes that a med depletes chromium. Nobody gave a firm dose beyond that, nobody said they stopped taking it, and no one raised a caution about it. Ashwagandha is a smaller ingredient in this product, and most of the panel likes it for stress, cortisol and sleep, though some advise taking breaks from it.