Pure Prescriptions Perfect Immune Review
Perfect Immune by Pure Prescriptions is a capsule immune formula sold as a 90 capsule bottle, with 30 servings per bottle and a suggested use of three capsules daily with a meal containing dietary fat. The page describes the formula as covering four nutrients: Vitamin A as retinyl palmitate, Vitamin C as ascorbic acid, vegan Vitamin D3 derived from lichen, and zinc citrate. The brand states that most immune formulas use low-cost, poorly absorbed forms of vitamins and minerals, and that Perfect Immune uses clinically validated forms at therapeutic doses to cover immune activation, regulation and antioxidant protection. Vitamin A is presented as supporting immune cell development and the integrity of mucosal membranes in the respiratory and GI tracts. Vitamin C is described as a water-soluble antioxidant that protects immune cells during active responses and supports collagen synthesis in mucosal barriers. Vegan D3 from lichen (Cladina rangiferina) is positioned as an alternative to lanolin-derived D3, with the page stating it has the same bioactivity. Zinc is described as required for T lymphocytes, NK cells and neutrophils, and the page says the citrate form is more bioavailable than oxide forms. The page explains that the product is designed by Dr. Devin Ryerson at Pure Prescriptions, founded in 1999, and that every batch is said to be third-party tested for purity and potency. Usage guidance recommends daily use year round rather than only when sick, and mentions higher demand periods such as travel, seasonal changes, high workload and intense training. The page suggests a timeline in which reserves rebuild in the first weeks, vitamin D3 levels rise by week four, mucosal support builds by week eight, and full benefits are expected by week twelve, while noting results vary. The Supplement Facts list per capsule shows 499.8 mcg vitamin A, 500 mg vitamin C, 8.33 mcg vitamin D, and 5 mg zinc, with the zinc listed as zinc picolinate in that table, which differs from the zinc citrate named elsewhere on the page. Other ingredients are hypromellose capsule and ascorbyl palmitate. The page states the capsule is vegetarian HPMC rather than gelatin. Pricing on the page starts at $36.00 for the 90 capsule one-time purchase, with 3 pack and 6 pack options and an auto-delivery option. The page also promotes the product as part of a doctor's protocol alongside NAC, Digestive Defense and Magnesium Glycinate, and states that the product is made in the USA.
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Study, Trial or Testing Result Summary
Members Only104 human studies · 35 improved
2 of these 104 human studies gave the ingredient by injection, not by mouth.
Vitamin C is at a full dose here. Across 29 trials, it did not make colds less common in the general public, but colds were about half as common in marathon runners, skiers and soldiers, and colds were 8 percent shorter in adults and 14 percent shorter in children [1]. Another pooled analysis found a 4 percent lower risk of respiratory infections and 9 percent shorter symptoms [2]. However, a review of eight reviews concluded vitamin C does not prevent colds [3]. Zinc reaches a full dose at two servings a day. It made little or no difference to catching a cold but may have shortened colds by about 2.4 days, with more mild side effects [4]. Vitamin D here is well below the studied dose. Even at the studied dose, results were mixed: one pooled analysis found about 12 percent lower odds of respiratory infection, mostly in very deficient people [5], while a trial of 15,804 older adults found no benefit [6]. The vitamin A dose's match to the studies is unclear, and the best evidence found that vitamin A did not reduce illness in mothers or infants [7]. Animal and cell studies are never counted.
See all 104 studies →Hide the studies
- In 14 trials of 25,758 mother and infant pairs, high-dose vitamin A given after birth raised breast milk vitamin A but did not reduce illness or death in mothers or infants compared with placebo or no treatment.Vitamin A supplementation for postpartum women.
- Across 25 trials with 11,321 people of all ages, vitamin D supplements lowered the odds of a sudden respiratory infection by about 12%, with the biggest benefit in very deficient people and those taking daily or weekly doses rather than large single doses.Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis.
- Across 29 placebo-controlled trials with 11,306 people taking at least 0.2 g of vitamin C daily, colds were not less common in the general public but were about half as common in marathon runners, skiers and soldiers, and colds lasted 8% shorter in adults and 14% shorter in children.Vitamin C for preventing and treating the common cold.
- Across 34 trials with 8526 children and adults, zinc made little or no difference to catching a cold but may have shortened colds by about 2.4 days when used as treatment, with more mild side effects.Zinc for prevention and treatment of the common cold.
- Across nine studies of 2,367 people, vitamin D deficiency was not overall linked to the immune response to flu vaccination, though protection rates for two strains were lower in deficient people.Does Vitamin D Deficiency Affect the Immunogenic Responses to Influenza Vaccination? A Systematic Review and Meta-Analys…
- A review of eight systematic reviews covering 31 randomized trials concluded that taking vitamin C does not prevent people from catching a common cold.Does vitamin C prevent the common cold?
- In a pooled analysis of randomized trials in adults, vitamin C slightly lowered the risk of respiratory infections by 4% and shortened symptoms by 9%, with a stronger prevention effect in men and in middle-income countries.Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic revie…
- In 10 placebo-controlled trials of healthy people taking at least 1 g of vitamin C daily, cold severity was 15% lower than with placebo, with a clear benefit on severe symptoms but not on mild ones.Vitamin C reduces the severity of common colds: a meta-analysis.
- Across 22 supplementation studies in people with multiple sclerosis, vitamin D3 did not clearly reduce relapses or disability overall, but high doses did lower the yearly relapse rate while low doses did not.Vitamin D status, supplementation, and multiple sclerosis: a systematic review and meta-analysis.
- In children with pneumonia, zinc may have slightly shortened hospital stays but did not speed recovery time, and no nutritional supplement could be recommended for routine treatment.A systematic review and meta-analysis on nutritional and dietary interventions for the treatment of acute respiratory in…
- Pooling 6 trials of adults with colds, zinc lozenges did not significantly reduce the chance of having cold symptoms at 7 days.A meta-analysis of zinc salts lozenges and the common cold.
- Five small, low-quality trials with 2,655 children and adults gave vitamin C at 125 mg to 2 g daily, and the evidence was too weak to tell whether it prevents or treats pneumonia.Vitamin C supplementation for prevention and treatment of pneumonia.
- A review of 39 randomized trials of eight supplements, including vitamin C, in healthy people under stress found some signs of benefit but too many gaps to draw firm conclusions about immune protection.Select Dietary Supplement Ingredients for Preserving and Protecting the Immune System in Healthy Individuals: A Systemat…
- A review of 13 studies in healthy adults found alternative vitamin C forms often raised white blood cell vitamin C and were better tolerated, with one study showing fewer colds, but more research is needed to confirm immune benefits.Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement …
- A review of 20 trials in healthy adults (8 on vitamin D) found micronutrients other than vitamin C, including vitamin D, may not prevent colds or reduce symptom severity.Zinc Supplementation Reduces Common Cold Duration among Healthy Adults: A Systematic Review of Randomized Controlled Tri…
- A review of 9 reviews found low vitamin D levels linked to higher risk of COVID-19 infection, but trials are still needed to confirm whether supplements help with severity or death.The role of vitamin D in prevention OF COVID-19 and its severity: an umbrella review.
- A review of the literature suggests vitamin D plays a role in innate immunity and that supplementation may help prevent or treat COVID-19, though this is a hypothesis.Vitamin D in SARS-CoV-2 infection.
- In a review of 14 diet trials in people with lupus, vitamin D was linked to better inflammation markers in most studies but not to better disease activity scores.Diet and Systemic Lupus Erythematosus (SLE): From Supplementation to Intervention.
- A review of 28 systematic reviews on diet and lupus looked at vitamin D among other nutrients but the abstract gives no clear result for vitamin D, and no specific dietary recommendations were established.The Interconnection Between Systemic Lupus Erythematosus and Diet: Unmet Needs, Available Evidence, and Guidance-A Patie…
- A guideline review of evidence made a conditional recommendation against vitamin D supplements for preventing eczema in children.Guidelines of care for the primary prevention of atopic dermatitis and awareness of comorbid conditions in pediatric ato…
- This review of common cold treatments covered zinc gel and lozenges among other options, but the abstract gives no results for zinc.Common cold.
- This review of common cold treatments covered zinc gel and lozenges among other options, but the abstract gives no results for zinc.Common cold.
- In 15,804 older adults, 2,000 IU of vitamin D3 daily did not significantly lower the risk of upper respiratory infection at 1 year compared with placebo.Effect of Daily Vitamin D Supplementation on Risk of Upper Respiratory Infection in Older Adults: A Randomized Controlle…
- In 8,851 schoolchildren in Mongolia, 14,000 IU of vitamin D3 weekly for 3 years did not lower tuberculosis infection (3.6% vs 3.3% with placebo), tuberculosis disease, or respiratory infection.Vitamin D Supplements for Prevention of Tuberculosis Infection and Disease.
- In 2157 adults aged 70 or older, 2000 IU of vitamin D3 daily for 3 years did not significantly reduce infection rates or improve blood pressure, physical performance, cognition, or fractures compared with placebo.Effect of Vitamin D Supplementation, Omega-3 Fatty Acid Supplementation, or a Strength-Training Exercise Program on Clin…
- In 1,444 army recruits taking 6,000 mg of vitamin C daily for 30 days, the risk of getting a common cold was 0.80 times that of those taking placebo.Vitamin C supplementation reduces the odds of developing a common cold in Republic of Korea Army recruits: randomised co…
- In 881 pregnant women, 4,400 IU daily of vitamin D started at 10-18 weeks of pregnancy did not lower preeclampsia compared with 400 IU (8.08% vs 8.33%), though women with higher vitamin D blood levels had lower risk.Early pregnancy vitamin D status and risk of preeclampsia.
- In 868 Navajo schoolchildren given vitamin C or placebo, there was no difference in how many got ill (133 vs 129), number of illness episodes, or illness length, though blood vitamin C levels were higher.Vitamin C and acute illness in Navajo schoolchildren.
- In 826 Indonesian preschool children given 10 mg zinc daily for 4 months, days with upper respiratory infection fell 12 percent (not significant), and 20 percent after vitamin A was given.Zinc combined with vitamin A reduces upper respiratory tract infection morbidity in a randomised trial in preschool chil…
- In a randomized trial of 688 adult women, 1 gram of vitamin C daily produced a small reduction in chest colds but no effect on simple colds.A randomized controlled trial of vitamin C in the prevention and amelioration of the common cold.
- In 674 marine recruits given 2 grams of vitamin C or placebo daily for eight weeks, colds were no less common or shorter, though the vitamin C group rated their colds as less severe.Vitamin C prophylaxis in marine recruits.
- In 597 Chinese infants revaccinated against tuberculosis, 3 months of daily vitamin A plus 500 IU vitamin D raised positive skin test response to 96.1% versus 89.7% in the control group.Enhancement of vitamin A combined vitamin D supplementation on immune response to Bacille Calmette-Guérin vaccine revacc…
- In 595 critically ill surgical patients, early antioxidant supplementation with vitamin C and vitamin E did not significantly reduce lung complications compared with standard care, but it reduced multiple organ failure and shortened time on the ventilator and in intensive care.Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients.
- In 408 adults with mild to moderate asthma, vitamin D for 28 weeks did not reduce cold severity or frequency compared with placebo, and African American participants had more colds on vitamin D.Vitamin D Supplementation and the Risk of Colds in Patients with Asthma.
- In a 5-year double-blind trial of older Japanese adults, 500 mg of vitamin C daily cut the number of people with three or more colds, compared with 50 mg daily, but did not shorten or lessen the colds.Effect of vitamin C on common cold: randomized controlled trial.
- In 275 people with early COVID-19, a 10-day combination therapy including vitamin C was safe and well tolerated, but the study did not test whether it improved immune health.Read the study on PubMed (41693032) →
- In 254 older adults with COVID-19, a single high dose of 400,000 IU vitamin D3 lowered deaths at 14 days compared with 50,000 IU (6% vs 11%), but the benefit was gone by 28 days.High-dose versus standard-dose vitamin D supplementation in older adults with COVID-19 (COVIT-TRIAL): A multicenter, ope…
- In 247 high school students, 2000 IU of vitamin D3 daily for 2 months did not lower overall influenza A (13.5% vs 12.1% on placebo), though a post hoc look showed fewer cases in the first month only.Effects of vitamin D supplements on influenza A illness during the 2009 H1N1 pandemic: a randomized controlled trial.
- In 245 breastfeeding mothers given 600 IU vitamin D2 plus 1800 IU vitamin A daily for 2 months, infant fever, respiratory infection, diarrhoea and eczema were not lower than with placebo; the effect of vitamin D alone cannot be separated.Impact of Maternal Daily Oral Low-Dose Vitamin A Supplementation on the Mother-Infant Pair: A Randomised Placebo-Control…
- In 228 health care workers, vitamin D2 raised blood vitamin D levels but did not change COVID-19 infection rates (50.5% vs 52.4%), symptoms, or inflammation markers compared with no treatment.Randomized trial of influence of vitamin D on the prevention and improvement of symptomatic COVID-19.
- In 311 National Institutes of Health employees taking 3 g of ascorbic acid daily for nine months (with extra doses at cold onset), the vitamin had at best a minor effect on the duration and severity of colds, and the results could be explained by a break in blinding.Ascorbic acid for the common cold. A prophylactic and therapeutic trial.
- In a double-blind study of 95 identical twin pairs over 100 days, vitamin C shortened cold episodes by about 19% but had no other significant effect compared with placebo.Vitamin C and the common cold: using identical twins as controls.
- In 127 Mexican children aged 5 to 15 months, vitamin A lowered norovirus GII infections and norovirus-linked diarrhea compared with placebo, but lengthened how long the virus was shed.Vitamin A supplementation has divergent effects on norovirus infections and clinical symptoms among Mexican children.
- In 120 stroke patients with swallowing difficulty, vitamin C stimulation added to routine swallowing training improved swallowing tests, nutrition markers and antibody levels compared with routine training alone.Effects of vitamin C stimulation on rehabilitation of dysphagia after stroke: a randomized trial.
- In 120 children with acute Kawasaki disease, adding vitamin D to standard treatment brought fever down faster (27 vs 50 hours) and lowered inflammatory markers compared with standard treatment alone.Read the study on PubMed (40996174) →
- In 112 women with repeated implantation failure, vitamin D alone gave a 17.8% pregnancy rate versus 10.7% for control, and only the combination with vaginal probiotics (46.4%) significantly changed immune markers.The effect of vitamin D supplementation and vaginal probiotics on fertility in women with recurrent implantation failure…
- In 98 adults with mild to moderate coronavirus illness, 1000 mg of vitamin C daily for 14 days had no effect on symptom progression or quality of life compared with placebo.A Pilot of a Randomized Control Trial of Melatonin and Vitamin C for Mild-to-Moderate COVID-19.
- In 91 adults with cystic fibrosis given a large vitamin D3 dose during a lung flare-up then every other week for a year, there was no difference from placebo in time to next flare-up or death, lung function, or an infection-fighting protein.Vitamin D for the Immune System in Cystic Fibrosis (DISC): a double-blind, multicenter, randomized, placebo-controlled c…
- In 91 health care workers given 5000 or 2000 IU of vitamin D3 daily for 3 months, vitamin D intake was not linked to lower COVID-19 illness, though the higher dose group had only asymptomatic cases.Vitamin D Intake May Reduce SARS-CoV-2 Infection Morbidity in Health Care Workers.
- In 87 lung transplant recipients, 100,000 IU of vitamin D monthly for 2 years did not change chronic lung rejection, inflammation or other outcomes compared with placebo.High-dose vitamin D after lung transplantation: A randomized trial.
- In 82 adolescent swimmers, 12 weeks of vitamin D3 versus placebo did not change thymus activity markers, and these were not linked to respiratory infection severity or duration.Thymus Activity, Vitamin D, and Respiratory Infections in Adolescent Swimmers.
- In 80 healthy adults with a new common cold, zinc gluconate nasal gel used four times daily until symptoms resolved (up to 10 days) shortened cold duration to a median of 4.3 days versus 6 days with placebo.Effect of zincum gluconicum nasal gel on the duration and symptom severity of the common cold in otherwise healthy adult…
- In 60 children prone to recurrent respiratory infections, a daily orange juice providing 70 mg of vitamin C was associated with a drop in infection episodes from about 6.75 to 2.62 per child.Beneficial therapeutic effects of vitamin C on recurrent respiratory tract infections in children: preliminary data.
- In 53 people with multiple sclerosis, 48 weeks of vitamin D3 did not change immune cell CD25 or IL2RA gene activity compared with placebo, though some CD25 measures fell only in the placebo group.Vitamin D3 supplementation and the IL-2/IL-2R pathway in multiple sclerosis: Attenuation of progressive disturbances?
- In 40 adults with active rheumatoid arthritis, adding vitamin D to standard drugs for 3 months raised regulatory immune cell levels more than standard drugs alone, alongside lower disease activity scores.Vitamin D: does it help Tregs in active rheumatoid arthritis patients.
- In 40 postmenopausal women, 2 mcg a day of active vitamin D3 for 2 weeks slightly raised CD3 and CD8 T cell counts while 1 mcg a day changed nothing and CD4 cells were unchanged.The effect of 1,25(OH)2 vitamin D3 on CD4+/CD8+ subsets of T lymphocytes in postmenopausal women.
- In 40 Air Force Academy cadets taking 15 mg of zinc gluconate daily for seven months, self-reported symptom-free episodes were significantly higher than with placebo, but doctor-diagnosed upper respiratory infections did not differ.Use of zinc supplements to reduce upper respiratory infections in United States Air Force Academy cadets.
- In 39 women with early rheumatoid arthritis, a single 300,000 IU dose of vitamin D3 added to standard treatment improved general health over 3 months, but did not change immune cell subtypes or bone-cell precursors.Vitamin D and immunomodulation in early rheumatoid arthritis: A randomized double-blind placebo-controlled study.
- In 38 hemodialysis patients, 12 weeks of vitamin D3 normalized blood vitamin D levels but did not change monocyte counts, T helper cell frequencies, or inflammation markers compared with placebo.Influence of cholecalciferol supplementation in hemodialysis patients on monocyte subsets: a randomized, double-blind, p…
- In 38 people with relapsing multiple sclerosis, high-dose vitamin D3 (20,400 IU every other day) reduced sugar-chain branching on T and natural killer cells but mostly did not change immune cell numbers compared with low-dose.Effect of vitamin D supplementation on N-glycan branching and cellular immunophenotypes in MS.
- In 32 people given 2,000 IU of vitamin D daily for 10 weeks before a tetanus booster shot, antibody response was slightly higher than with placebo, while other immune measures were similar.Efficient tetanus toxoid immunization on vitamin D supplementation.
- In 28 people recovering from COVID-19, a single 1000 mg dose of vitamin C reduced one type of immune-related reactive oxygen species by 45% but did not raise nitric oxide levels.A Plant-Based Dietary Supplement Exhibits Significant Effects on Markers of Oxidative Stress, Inflammation, and Immune R…
- In 28 healthy adults with an induced chemical skin rash, a single 200,000 IU dose of vitamin D3 reduced skin inflammation in all participants, with effects lasting 6 weeks.Vitamin D3 and deconvoluting a rash.
- In 24 patients receiving stem cell transplants for myeloma or lymphoma, high-dose vitamin C (20 g daily for 10 days, then 500 mg twice daily until day 100) was linked to rising natural killer and CD3 immune cell counts from day 30 to day 100 and fewer infections, compared with standard care alone.Effect of vitamin C on immune reconstitution after bone marrow transplantation.
- In 22 hospitalized people with mild COVID-19 and heart disease, 10,000 IU of vitamin D3 daily reduced inflammatory markers and was linked to less severe illness, fewer hospital days, and lower death rate than placebo.Vitamin D3 supplementation in COVID-19 patients with cardiovascular disease and gut dysbiosis.
- In 20 children having surgery, ascorbate before premedication did not change neutrophil mobility during anaesthesia or surgery, and no infections occurred.Neutrophil mobility during anaesthesia in children. A trial of ascorbate premedication.
- In 12 adults who exercised for about two hours in heat, 1500 mg of vitamin C daily for 12 days lowered the stress hormone cortisol after exercise, but did not change salivary antibody levels or cold-like symptoms compared with placebo.Vitamin C supplementation and salivary immune function following exercise-heat stress.
- In healthy adults aged 55 and older, a 12-week multivitamin and mineral supplement raised blood vitamin C and zinc levels but did not change measured immune function compared with placebo.The Effect of a Multivitamin and Mineral Supplement on Immune Function in Healthy Older Adults: A Double-Blind, Randomiz…
- In older adults, a 30-day course of a multi-ingredient supplement that also contained vitamin C lowered inflammatory blood markers and improved lymphocyte levels, though they did not reach the levels seen in younger people; the vitamin C dose was not stated.Use of Nutraceuticals in Elderly to Fight Inflammation and Immuno-Senescence: A Randomized Case-Control Study.
- In a randomized trial of ultramarathon runners and sedentary controls, taking 600 mg of vitamin C daily was linked to fewer upper airway infection symptoms in the two weeks after a race than placebo, with 33% of supplement takers developing symptoms versus 68% of placebo takers among runners.Vitamin C supplementation reduces the incidence of postrace symptoms of upper-respiratory-tract infection in ultramarath…
- In HIV-infected adults in a flu vaccine trial, taking vitamin D supplements did not improve the immune response to the vaccine.Vitamin D supplementation does not increase immunogenicity of seasonal influenza vaccine in HIV-infected adults.
- In a 3-month supplementation study of breastfeeding mothers and infants, higher maternal vitamin D status was linked to lower infant TNF levels and stronger infant immune cell responses to challenge, with some responses tied to the infant's own vitamin D.Maternal Vitamin D Status Correlates to Leukocyte Antigenic Responses in Breastfeeding Infants.
- In two trials of 8-9 year old children (172 and 642) given 1000 mg vitamin C daily, cold duration and severity seemed lower but cold incidence stayed the same or rose, and the total sick days were fewer only in the smaller pilot study.Vitamin C as a preventive medicine against common colds in children.
- In about 210 students (three groups of about 70) taking 1 gram daily for 15 weeks, the D-isoascorbic acid group had 34% fewer colds than the other two groups, which included the L-ascorbic acid group, so regular vitamin C showed no clear benefit.L-Ascorbic acid and D-isoascorbic acid in a common cold survey.
- Among 180 COVID-19 patients, those with vitamin D deficiency were hospitalized more often (41.3% vs 12.5%), and those given vitamin D3 recovered from hospital about 5 days sooner than deficient patients.Importance of Vitamin D3 in COVID-19 Patients.
- In 16 people with cystic fibrosis, 3 months of vitamin D2 or D3 was linked to lower T cell activation markers in a dose-dependent way compared with controls.Vitamin D treatment modulates immune activation in cystic fibrosis.
- In 8 healthy men, a 10-week low-zinc diet (4.6 mg a day) reduced immune cell proliferation, which stayed reduced after 5 weeks of 9.1 mg zinc a day, while immune cell numbers and several other immune measures did not change.Immune functions are maintained in healthy men with low zinc intake.
- In a large double-blind trial, 1 g of vitamin C daily gave a small, non-significant reduction in colds, but more people stayed illness-free and vitamin takers had about 30% fewer days of disability from illness than placebo takers.Vitamin C and the common cold: a double-blind trial.
- In older adults, 500 mg of vitamin C injected daily for one month improved T-lymphocyte response and skin test reaction compared with placebo, but did not change antibody levels.Effect of vitamin C supplements on cell-mediated immunity in old people.
- In infertile women with low vitamin D, supplementation (23 tested before and after) lowered the ratio of Th1 to Th2 immune cells, and 11 of 23 (47.8%) reached sufficient vitamin D levels.Vitamin D Regulates Maternal T-Helper Cytokine Production in Infertile Women.
- In a small feasibility study of people with a new common cold, 250 mg of vitamin C daily for 5 days was used only as the comparison arm against a warm humidified air treatment, and the abstract reports no benefit from vitamin C itself.Randomised controlled trial of rhinothermy for treatment of the common cold: a feasibility study.
- In 18 older adults low in vitamin D, taking 6,400 IU of vitamin D3 daily for 14 weeks strengthened the skin immune response to a chickenpox virus antigen and reduced inflammatory cell build-up.Vitamin D3 replacement enhances antigen-specific immunity in older adults.
- In healthy young adults in Cape Town given high-dose vitamin D3 in winter, HIV-1 replication in blood cells fell, circulating white blood cells rose, and winter-associated anemia reversed.High-dose vitamin D3 reduces deficiency caused by low UVB exposure and limits HIV-1 replication in urban Southern Africa…
- In people with inflammatory bowel disease, 12 weeks of vitamin D was linked to lower disease activity and inflammation markers and shifts in immune responses to gut bacteria, with no control group.Multi-omics reveal vitamin D regulation of immune-gut microbiome interactions and tolerogenic pathways in inflammatory b…
- In 250 Nigerian children under five with respiratory infections compared with 250 without, blood vitamin D was slightly lower in those with infections and lowest in those with lower respiratory infections.Vitamin D and Acute Respiratory Infections in Children.
- In a study of 433 women followed for a year, those with the highest dietary vitamin C intake were less likely to have a persistent human papillomavirus infection than those with the lowest intake.Dietary intake and risk of persistent human papillomavirus (HPV) infection: the Ludwig-McGill HPV Natural History Study.
- In 414 severely ill COVID-19 patients, lower vitamin D3 blood levels on admission were linked to higher inflammation markers, longer stays, more ventilator days and death.Cholecalciferol level and its impact on COVID-19 patients.
- In 207 Nigerian children with fever, eating red palm oil, a source of vitamin A precursors, had little effect on malaria severity.Lack of influence of red palm oil on severity of malaria infection in pre-school Nigerian children.
- After measles, preschool children had low vitamin A levels, frequent infections for about six months, and slower weight gain, although vitamin A therapy improved their eye lesions.Effect of measles on the nutritional status of preschool children.
- In 80 adults with dengue, lower blood vitamin D levels were linked to more severe disease, but no supplement was given.Association of systemic vitamin D on the course of dengue virus infection in adults: a single-centre dengue cohort study…
- In 37 patients with skin infections called phlegmons, those given zinc tablets after low serum zinc was found had no further lesions for more than 10 months, though the study was uncontrolled.Serum zinc levels in patients with phlegmons as a marker of the severity of infection and the potential of zinc suppleme…
- In 16 children with vitamin D deficient rickets compared with 15 healthy children, low vitamin D went along with fewer T cells and more frequent infections; no supplement was tested.Lymphocyte subpopulations in children with vitamin D deficient rickets.
- In hospital records of patients with upper respiratory tract infection, adding vitamin C injection to Xiyanping injection did not improve cure rates compared with Xiyanping alone.[Analysis of actual effects of combining xiyanping injection with vitamin C injection in treatment of upper respiratory …
- In a large population study of adults in Catalonia, cholecalciferol was linked to slightly lower COVID-19 infection risk (4.0% vs 4.2%), and both forms were linked to better outcomes only in people reaching blood levels of 30 ng/ml or higher, while calcifediol overall did not reduce infection or death.Vitamin D supplementation and COVID-19 risk: a population-based, cohort study.
- In healthy German adults followed for 24 weeks after COVID-19 vaccination, antibody response did not differ by vitamin D blood level.Relationship between Vitamin D Status and Antibody Response to COVID-19 mRNA Vaccination in Healthy Adults.
- Young vegetarians and vegans had more zinc deficiency than omnivores, and this deficiency was linked to lower interleukin-2 production and weaker immune function.Reduced interleukin-2 production and increased CREMα protein expression in vegetarians and vegans due to zinc deficiency…
- In 35 adults with chronic immune thrombocytopenia who had failed meds or splenectomy, the meds all-trans retinoic acid raised platelet counts in 54% of patients, and this drug is not a standard vitamin A supplement.Efficacy of immunomodulatory therapy with all-trans retinoid acid in adult patients with chronic immune thrombocytopenia…
- In 19 hemodialysis patients given influenza vaccine, 4 weeks of zinc acetate (60 mg elemental zinc daily) did not increase antibody responsiveness to the vaccine.Influenza vaccination in chronic hemodialysis patients. The effect of zinc supplementation.
- In 19 healthy older adults, moderate zinc supplementation reduced spontaneous inflammatory cytokine release and improved T cell response to stimulation.Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions.
- In 12 healthy volunteers, a nasal dose of 400 IU cholecalciferol did not produce detectable levels of the antimicrobial peptide hBD-2, while bacterial lysates did.Human β-defensin-2 induction in nasal mucosa after administration of bacterial lysates.
- In 6 patients with acrodermatitis enteropathica, low zinc levels were linked to weaker T and B cell responses, and these normalized when zinc levels recovered with supplementation.Abnormal immune responses during hypozincaemia in acrodermatitis enteropathica.
- In people with Sjogren's syndrome, 100,000 units of vitamin A daily for two weeks increased some immune cell killing activity but also raised a marker of fat damage in the blood.Effect of vitamin A treatment on immune reactivity and lipid peroxidation in patients with Sjögren's syndrome.
- In laboratory dishes, vitamin D changed activation markers on immune T-cells, but in 10 healthy people blood vitamin D levels were not significantly linked to those markers.Vitamin D modulates the expression of HLA-DR and CD38 after in vitro activation of T-cells.
- In volunteers with experimentally produced colds, zinc gluconate removed the drop in choice reaction time seen during the cold.Effects of zinc gluconate and nedocromil sodium on performance deficits produced by the common cold.
Review Totals and Summary
Members Only38 reviews
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Biohacker Summary
Members Only10 of 10 recommend it
The product has no single main ingredient in the statements, so the panel's comments cover its smaller ingredients, mostly vitamin D, zinc and vitamin C. Vitamin D drew the most support: most of the panel recommend or use it, citing immune health, mood, muscle, fertility and general health, and one takes 5000 IU of D3 each morning while another suggests taking it on days without liver. Zinc is recommended by several for immunity, testosterone, sperm health and mood, with doses of 15 milligrams in the morning and 30 milligrams for men preparing for IVF, and one panelist uses a gut-lining form called zinc carnosine. Vitamin C is recommended by a few for inflammation, detox support and recycling the body's antioxidants, though one cautions that the best dose is unclear and high doses might blunt the benefits of exercise. Another panelist adds that supplementing vitamin D mostly makes sense if you are deficient, and vitamin A is a smaller ingredient that was only mentioned as a food nutrient.
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Dr. Eric Berg · Vitamin D · warns
- Dr. Berg warns that the recommended daily intake for vitamin D is based on a massive error and that the actual necessary amount is closer to 8,895 IU, with millions remaining deficient.
- Recommends getting vitamin D levels tested to ensure they are between 50 and 70, as vitamin D is intimately involved in regulating prostate size.
- Recommends ensuring sufficient zinc intake because the prostate needs enough zinc for the conversion from testosterone to DHT to be smooth and optimized.
- Recommends taking at least 10,000 IUs of vitamin D3 every single day in the winter, stating it is the most important vitamin to lower cancer risk.
- Recommends vitamin D to support the immune system, aiming for blood levels between 80 to 100 ng per ml.
- Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
- Recommends taking no less than 10,000 IU's of vitamin D3 for osteoporosis, alongside magnesium and K2.
- Recommends increasing vitamin D to restore balance and support healthy blood pressure.
- Dr. Berg states that Vitamin C helps fight biofilms and is essential for making collagen in gums, teeth, and capillaries.
- States that a lack of vitamin D can potentially cause achy bones or crashing mood.
- Recommends taking zinc carnosine for an ulcer or some type of gastric problem.
- Recommends Vitamin C as a cofactor, especially for collagen.
- Notes that low vitamin A can lead to dry eyes, dry mouth, and night vision issues.
- States that vitamin D is intimately involved in the immune system and recommends taking at least 10,000 IUs each day.
Dave Asprey · Vitamin D · uses
- Takes Vitamin DAKE from Suppgrade Labs.
- Suggests that vitamin D supports brain health, muscle function, and focus.
- Recommends taking vitamin C for better skin health.
- Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense for male fertility, even though supplementation did not improve overall semen parameters in a randomized trial.
- States that currently, he is only taking vitamin C and vitamin D.
- States that currently, he is only taking vitamin C and vitamin D.
- Developed a nonnano zinc sunscreen over five years, stating her skin is probably better now than it's ever been.
- Recommends vitamin D, noting it's actually a hormone and that most people are deficient, even those who take it, because they don't take enough.
- States that most people on the spectrum are low in vitamin D and need more of it, mentioning his own product, Vitam DAKNE, which contains real vitamin A.
- Emphasizes the importance of having enough zinc before trying advanced longevity strategies like peptides.
- Recommends real vitamin A for people on the spectrum, noting that many cannot convert plant vitamin A and need the good stuff he includes in his Vitam DAKNE product.
- Suggests that zinc has better safety and protective data than meds for reducing cardio respiratory risk.
- Dave Asprey recommends Vitamin D3 with K2, explaining D3 is a hormone made from sunlight and K2 directs calcium into bones, not arteries, highlighting its low cost, widespread deficiency, and the ability to test its effectiveness.
- Recommends Vitamin D as one of the most important supplements for overall health.
Siim Land · Vitamin D · recommends
- Advises against taking vitamin D in the morning with other supplements because it is fat soluble and requires dietary fat for better absorption.
- Recommends taking Vitamin D with fat for better absorption.
- Recommends taking vitamin C with collagen to support joint collagen synthesis.
- States that Vitamin D connects biology to light and that UVB reaching the skin enables its production.
- States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
- Lists sauerkraut and fruit as sources of Vitamin C.
- Lists liver and carrots as sources of Vitamin A.
- Thinks vitamin D has some of the strongest evidence and is worth considering.
- Notes that Vitamin K2 pairs well with vitamin D by regulating calcium and bone mineralization.
- Notes that Vitamin C is one of several supplements with human evidence.
- Recommends taking vitamin D supplements with some fat to maximize its absorption, suggesting with food or a teaspoon of olive oil.
- Notes that taking vitamin D3 with a fat-containing meal resulted in 32% higher peak blood vitamin D levels.
- Recommends taking Vitamin D in the morning or at lunch with fat.
- Notes that Boron improves vitamin D.
Andrew Huberman · Zinc · uses
- Zinc carnosine to support and improve the lining of your gut.
- Notes that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
- States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
- Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
- States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut, and he was already taking some of these ingredients separately.
- States that AG1 Pro includes zinc carnosine, which he was already taking separately, to support and improve the lining of the gut.
- Notes that most people are probably deficient in vitamin D and benefit from supplementing, but there's no point in doing it unless you're deficient for most things.
- Personally takes zinc carnosine, which is included in AG1 Pro to support and improve the lining of the gut.
- AG1 Pro has zinc carnosine to support and improve the lining of your gut. Some of these ingredients I personally was already taking separate from the AG1 formula.
- States that AG1 Pro contains zinc carnosine to support and improve the lining of your gut.
- Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
- Takes 5,000 IU of Vitamin D3 in the morning for longevity.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- States that Vitamin D is one of the critical nutrients with the best evidence for cognitive function and reducing the risk of dementia.
Ben Greenfield · Zinc · warns
- Ben Greenfield's formulation includes 30 grams of zinc a day, taken for one week before surgery and two weeks after, as it is an important cofactor for wound healing.
- States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
- Notes that Vitamin D is actually a hormone and recommends patients aim for levels around 40 to 50, or even 60 for fracture healing, for optimal healing, as opposed to just above 20 which is considered normal.
- Notes that Vitamin A is a fat-soluble vitamin that supports healthy skin cell turnover.
- Mentions vitamin C as part of a bare-minimum protocol.
- Mentions vitamin D as part of a bare-minimum protocol.
- Advises getting vitamin D levels between 60 and 100 nanograms per milliliter as a minimum step for overall health and to slow down heart disease.
- Emphasizes that zinc sufficiency is crucial for immunity because the thymus-derived peptide thymulin, which trains lymphocytes, requires zinc to be active.
- Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
- Recommends adding zinc into one's stack because it is a co-factor for enzymes involved in testosterone synthesis and sperm maturation, and zinc deficiency is a reproducible cause of low sperm count.
- He mentions zinc as a supplement with real human data behind it for male fertility.
- Zinc may support both testosterone and sperm count.
- Notes that IV vitamin C has been used for decades for cancer patients with almost no standardization and that he receives many questions about its effectiveness and combination with chemo.
- Has been taking Vitamin D3 K2 for over a decade.
Dr. Mark Hyman · Vitamin D · recommends
- Recommends Vitamin D for health, stating that amazing things happen when patients' vitamin D statuses reach optimal levels.
- Mentions vitamin D as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
- Notes that vitamin D plays a role in immune function.
- Mentions that vitamin A levels can be looked at to get a deep sense of what's happening with nutrient levels.
- Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
- Recommends checking vitamin D levels and states that if they had to pick one single intervention for immune health, vitamin D would be it.
- Dr. Hyman discusses vitamin D in relation to sun exposure patterns.
- States that vitamin D supplementation can help with oxidative stress.
- Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
- Mentions topical vitamin C as an antioxidant that can help skin with aging.
- Gave a patient with psoriatic arthritis a little zinc, which contributed to significant improvement in her condition.
- Mentions that what they do when a cold comes on is not just vitamin C.
- Mentions vitamin D as a key nutrient for supporting immune function.
- States that vitamin D is probably the single most important intervention for immune health, recommending levels of 45 to 70 and emphasizing testing to determine the right dose.
Thomas DeLauer · Vitamin C · recommends
- Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
- Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
- Adds zinc to their immunity duo because it helps them absorb vitamin C, considering the two together a fantastic combination for fall and winter.
- Uses vitamin D3 in the fall and winter months when getting less sun, as it's important to supplement it then.
- Recommends taking a massive amount of vitamin D simultaneously with an early morning massive breakfast to help reset circadian rhythms and address hyperphagia.
- Recommends zinc, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
- Recommends Vitamin D, stating that it has receptors throughout the brain and deficiency can quickly impact brain and mood.
- Takes supplemental vitamin D because he is skin sensitive and from northern latitudes, limiting his UV exposure.
- Recommends taking vitamin D on non-liver days to ensure both nutrients get proper receptor access.
- Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
- Mentions that more zinc could be beneficial for testosterone, but it's not working on the axis that most people need help with.
- Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
- Takes Purity's liquid vitamin D3 with K2 because she is constantly inside during the day; D3 is for overall wellness and K2 helps the body absorb calcium properly.
- Compares the Vitamin C content of oranges (53mg) to guava (228mg), noting guava has 4x more.
Bryan Johnson · Vitamin D · uses
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Mentions that the sunlight assessment claims low vitamin D levels cause the immune system to misfire, and notes that their vitamin D has been measured.
- Takes 5000 IU of Vitamin D3 in the morning for longevity.
- Takes 15 mg of Zinc in the morning for longevity.
- He takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 5,000 IU of Vitamin D3 in the morning for longevity.
- Takes 5,000 IU of Vitamin D3 in the morning.
- Takes 15 mg of Zinc in the morning.
- Takes 5,000 IU of Vitamin D3 in the morning.
- He takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 15 mg of Zinc in the morning for longevity.
- Uses Vitamin C as an example of how it would be great if people knew that when they took it, it had a measurable amount and wasn't polluted, which is what Brian ensures with his products.
Dr. Rhonda Patrick · Vitamin D · neutral
- Vitamin D supplementation was linked to a 40% lower risk of dementia in an observational study of more than 12,000 older adults.
- Mentions that vitamin D also plays a role in maintaining muscle mass.
- Notes that not getting enough zinc can affect testosterone, as zinc is very important for testosterone synthesis.
- Recommends ensuring adequate vitamin D intake for men's sperm health.
- Recommends men take a 30 milligram zinc supplement for sperm health when preparing for IVF.
- Vitamin D and strength training alone did not, but adding them strengthened the effect on one clock, with the full combination slowing that measure by ~3.8 months.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Discusses findings from a meta-analysis on zinc supplementation, noting it improved insulin resistance, inflammation, and oxidative stress in people with diabetes or prediabetes, and explains its biological role in the pancreas.
- Recommends Vitamin D, noting it regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity, and correcting deficiency may slow epigenetic aging.
- Uses Vitamin D3 as an example of a supplement that an AI model could track to see its impact on other metrics like glucose levels.
- Recommends Vitamin D, explaining that it regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity.
- Combining omega-3s with vitamin D and exercise has an additive effect, translating to ~3 months of slowed biological aging.
Peter Attia · Vitamin D · uses
- Lists vitamin D as one of her staple supplements.
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Notes that several studies show patients taking vitamin D can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
- States that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin D for both sexes.
- Notes that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin A for male mice.
- Uses vitamin D as an example of how people might dismiss its efficacy due to failed clinical trials that didn't adjust the dose or measure levels.
- In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin D for both sexes.
- In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin A for male mice.
- Suggests that supplementing with lots of vitamin D might help overcome the negative effects of phenytoin on bone health by improving calcium absorption, though he is unaware of studies on this.
- Recommends Vitamin D3 as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 800 to 1,000 IU, which can be obtained through sunlight or supplementation.
- Suggests that supplementing with lots of vitamin D might overcome the negative effects of phenytoin on bone health by counteracting increased catabolism of vitamin D and subsequent decreased calcium absorption.
- Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
- Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
- Recommends vitamin D for people who tend to be vitamin D deficient, such as those living in Portland, Oregon.
RAL Summary
Members OnlyTier 4 for Immune Health
Emerging tier because pooled trials suggest vitamin C at this dose may modestly shorten colds [1], but only 10 reviews exist so far, too few to confirm it.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 40 of the 104 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Immune system, Respiratory system
Combine with: To further enhance immune system support, consider combining Perfect Immune with a high-quality probiotic supplement to support gut health, which is intrinsically linked to immune function. Omega-3 fatty acids, such as EPA and DHA from fish oil, can also be beneficial due to their anti-inflammatory properties that help modulate immune responses. Additionally, incorporating adaptogenic herbs like Astragalus or medicinal mushrooms like Reishi or Chaga could provide broader immune system modulation and resilience.
Possible side effects: Zinc used for colds caused more mild side effects than placebo, and a very high daily dose of vitamin A raised a blood marker of fat damage in one small study.
Supplement Facts
Vitamin A 499.8 mcg (IU) · Vitamin C 500 mg · Vitamin D 8.33 mcg (IU)
| Vitamin A (as Retinyl Palmitate) | 499.8 mcg (IU) | 56 |
| Vitamin C (Ascorbic Acid) | 500 mg | 556 |
| Vitamin D (as Cholecalciferol) (from Lichen) (vegan) | 8.33 mcg (IU) | 42 |
| Zinc (as Zinc Picolinate) | 5 mg | 45 |
Other ingredients: Hypromellose (capsule), Ascorbyl Palmitate.
Directions: Adults take 1-3 capsules daily, with our without food or as directed by your health care professionals. Children ages 4-12 may take 1 capsule daily.
Label source: Pureprescriptions · Report a label change
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Our articles on this subject
- What Supplements and Vitamins Should Not Be Taken TogetherArticle · Sep 7, 2026
- When Is the Best Time to Take Vitamins and Supplements?Article · Jun 15, 2026
Graded October 24, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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