Puritan's Pride Chewable Super Papaya Enzyme Plus Review
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Study, Trial or Testing Result Summary
Members OnlyHuman studies
This chewable papaya enzyme product lists a single proprietary blend of 6 milligrams per serving. Because the blend is proprietary, the label does not show how much of each ingredient it contains, so no amount can be compared with a studied dose. We found no human studies testing any of its ingredients for reversing aging or for cellular and DNA repair. With no ingredient findings to draw on, there is no study evidence that this product slows aging, rejuvenates cells or repairs DNA. Customer ratings are strongly positive, with about 1400 ratings and 95 percent of them favorable. However, no written reviews could be read, so we do not know what buyers were rating or whether any of them mentioned aging-related effects. Enzyme products like this one are often bought for other reasons, and a high rating cannot stand in for study evidence on this goal. Members interested in reversing aging should know that this product has no study support for that purpose at this time. Animal and cell studies are never counted.
Review Totals and Summary
Members Only1,400 reviews · 95% positive
Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.
Biohacker Summary
Members Only0 of 10 recommend it
The only ingredient the panel spoke about here is papain, which is a smaller ingredient in this product, and just three of the ten panelists commented on it. One panelist recommends it, using high doses as an enzyme to break down yeast and candida films, and says a product with papain helped his inflammation and soreness after a long endurance race. Another stayed neutral, noting that papaya enzymes break down proteins and may aid digestion, and he described a mouse study using 1 milligram. The third, also neutral, only noted that many foundational supplements now include papain. No one on the panel gave a caution or said they stopped taking it, and no one named a preferred form or something to pair it with.
See all 3 biohackers →Hide the biohackers
Thomas DeLauer · Papain · neutral
- Mentions that papaya contains enzymes like papain and bromelain, which are powerful at breaking down proteins and potentially helping to extract more amino acids by increasing digestion.
- Discusses a study where mice were given 1 milligram of papain, which increased levels of Akkermansia muciniphila and the thickness of the mucosal layer, and selectively increased intestinal permeability for nutrient absorption.
Ben Greenfield · Papain · recommends
- Recommends high-dose papain as a proteolytic enzyme to break down candida and yeast biofilms.
- He believes papain, which is in a product he uses, helped with inflammation and soreness after his Ironman.
Andrew Huberman · Papain · neutral
- Mentions that many foundational supplements now include papain.
RAL Summary
Members OnlyTier 4 for Healthy Aging
Tier 3 needs some study support, but no human studies on this goal were found for any of its ingredients, so the evidence is thin and supports tier 4. So it is graded Tier 4, lower than the rules alone gave.
- Emerging: not enough evidence to rank higher yet.
- No human studies on this goal for its ingredients.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Digestive system
Combine with: Combine with a healthy diet and lifestyle.
Possible side effects: No major side effects reported.
Supplement Facts
Proprietary Blend 6 mg
| Proprietary Blend | 6 mg | † |
Other ingredients: Sorbitol, Mannitol, Calcium Carbonate, Maltodextrin, Stearic Acid, Magnesium Stearate, Silica, Dicalcium Phosphate, Oil of Peppermint.
Directions: Directions: For adults, chew three (3) wafers with a meal up to three times daily as needed.
Barcode (UPC) 074312109829 · Label source: NIH label database · Report a label change
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- Healthy Aging Tips: A Science-Backed Guide to Living Better for LongerArticle · Mar 17, 2026
- NAD Anti-Aging Supplements: Benefits, Evidence, and How to ChooseArticle · Jun 15, 2026
Graded November 10, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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