Puritan's Pride Chewable Super Papaya Enzyme Plus Review

Product Focus: Healthy AgingAlso covers:Digestion
Tier ⓘ
Tier 4 · Rank 1
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 1 within Tier 4 for Healthy Aging; 131 of 168 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
43 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
95% of 1,400
Biohacker Mentions
0 of 10

Study, Trial or Testing Result Summary

Members OnlyHuman studies

This chewable papaya enzyme product lists a single proprietary blend of 6 milligrams per serving. Because the blend is proprietary, the label does not show how much of each ingredient it contains, so no amount can be compared with a studied dose. We found no human studies testing any of its ingredients for reversing aging or for cellular and DNA repair. With no ingredient findings to draw on, there is no study evidence that this product slows aging, rejuvenates cells or repairs DNA. Customer ratings are strongly positive, with about 1400 ratings and 95 percent of them favorable. However, no written reviews could be read, so we do not know what buyers were rating or whether any of them mentioned aging-related effects. Enzyme products like this one are often bought for other reasons, and a high rating cannot stand in for study evidence on this goal. Members interested in reversing aging should know that this product has no study support for that purpose at this time. Animal and cell studies are never counted.

Review Totals and Summary

Members Only1,400 reviews · 95% positive
1,400 reviews · Google Shopping 1,400
95% positive0% neutral5% negative

Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.

Biohacker Summary

Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it

The only ingredient the panel spoke about here is papain, which is a smaller ingredient in this product, and just three of the ten panelists commented on it. One panelist recommends it, using high doses as an enzyme to break down yeast and candida films, and says a product with papain helped his inflammation and soreness after a long endurance race. Another stayed neutral, noting that papaya enzymes break down proteins and may aid digestion, and he described a mouse study using 1 milligram. The third, also neutral, only noted that many foundational supplements now include papain. No one on the panel gave a caution or said they stopped taking it, and no one named a preferred form or something to pair it with.

See all 3 biohackers →Hide the biohackers
  • Thomas DeLauer · Papain · neutral
    • 25 Mar 2025 · neutral · YouTube ↗
      Mentions that papaya contains enzymes like papain and bromelain, which are powerful at breaking down proteins and potentially helping to extract more amino acids by increasing digestion.
    • 3 Sep 2024 · neutral · YouTube ↗
      Discusses a study where mice were given 1 milligram of papain, which increased levels of Akkermansia muciniphila and the thickness of the mucosal layer, and selectively increased intestinal permeability for nutrient absorption.
  • Ben Greenfield · Papain · recommends
    • 1 Apr 2023 · recommends · YouTube ↗
      Recommends high-dose papain as a proteolytic enzyme to break down candida and yeast biofilms.
    • Date not recorded · uses · Website ↗
      He believes papain, which is in a product he uses, helped with inflammation and soreness after his Ironman.
  • Andrew Huberman · Papain · neutral
    • 9 Jan 2023 · neutral · YouTube ↗
      Mentions that many foundational supplements now include papain.

RAL Summary

Members OnlyTier 4 for Healthy Aging

Tier 3 needs some study support, but no human studies on this goal were found for any of its ingredients, so the evidence is thin and supports tier 4. So it is graded Tier 4, lower than the rules alone gave.

  • Emerging: not enough evidence to rank higher yet.
  • No human studies on this goal for its ingredients.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Digestive system

Combine with: Combine with a healthy diet and lifestyle.

Possible side effects: No major side effects reported.

Supplement Facts

Proprietary Blend 6 mg
Supplement Facts
Serving Size 3 Wafer(s)
Servings Per Container 60
Amount Per Serving% Daily Value
Proprietary Blend6 mg†
† Daily Value not established.

Other ingredients: Sorbitol, Mannitol, Calcium Carbonate, Maltodextrin, Stearic Acid, Magnesium Stearate, Silica, Dicalcium Phosphate, Oil of Peppermint.

Directions: Directions: For adults, chew three (3) wafers with a meal up to three times daily as needed.

Barcode (UPC) 074312109829 · Label source: NIH label database · Report a label change

Show entire label

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Our articles on this subject

Graded November 10, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.