Quantum Circulation Support Review
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Study, Trial or Testing Result Summary
Members OnlyHuman studies
This product lists a nattokinase complex at 135 milligrams a day, alongside a 1030 milligram proprietary blend whose contents and amounts are not shown. How much of the complex is actual nattokinase is unclear. No study in people has tested nattokinase for aging or cellular repair, and none of the studies measured biological age. All of the evidence comes from animals and cells. In mice and immune cells, nattokinase lowered inflammation, oxidative stress and clotting signals, and protected the kidneys from injury caused by a bacterial toxin [1]. In rats exposed to bisphenol A or radiation, it improved liver function, lowered oxidative stress and inflammation in the brain, eased memory-related chemical deficits, and reduced buildup of misfolded proteins [2]. In rats given nattokinase daily for seven days before an induced stroke, higher doses reduced brain damage, improved neurological symptoms, and lowered markers of inflammation, clotting and oxidative stress [3]. These results may not carry over to people, and the doses used in the animals could not be confirmed or compared with this product. Animal and cell studies are never counted.
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Review Totals and Summary
Members Only81 reviews · 87% positive
Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.
Biohacker Summary
Members Only0 of 10 recommend it
Nattokinase gets mostly favorable but mixed views from the panel: four of the nine who spoke recommend it, two use it, two are neutral, and one warns that the evidence is not convincing for heart or stroke prevention. People take it for healthy circulation and clotting, to clear arterial plaque, and to lower LDL cholesterol, and one panelist said a follow-up blood test showed it worked for him. Several stress high doses, citing 8,000 units or more, 10,000 units a day, or 12,000 up to 20,000 units, because low-dose products showed little effect in the data they cite, and one suggested taking it at night on an empty stomach or while fasting. Others use it to break up bacterial biofilms or to lower lipoprotein little a by 20 to 30 percent, and one prefers fermented soybeans (natto) over pills. Cautions include one panelist warning against taking it with meds, another doubting that an enzyme survives stomach acid, and a call for more trials to find the effective dose.
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Andrew Huberman · Nattokinase · uses
- Started supplementing with nattokinase to naturally help reduce LDL cholesterol after learning his blood lipids were slightly out of range.
- Started supplementing with nattokinase after a Function Health test revealed slightly out-of-range blood lipids, and a follow-up test confirmed it helped reduce his LDL cholesterol.
- Learned from a Function test that some of his blood lipids were slightly out of range, so he decided to start supplementing with nattokinase, which naturally helps reduce LDL cholesterol, and it worked.
- Started supplementing with nattokinase to naturally help reduce LDL cholesterol after a Function test showed his blood lipids were slightly out of range, and a follow-up test confirmed it worked.
- Started supplementing with nattokinase to naturally help reduce LDL cholesterol after a Function test showed his blood lipids were slightly out of range, and a follow-up test confirmed its effectiveness.
- Started supplementing with nattokinase after a Function Health test showed his blood lipids were slightly out of range, and a follow-up test confirmed this strategy worked to reduce LDL cholesterol.
- Started supplementing with nattokinase after a Function Health test showed some blood lipids were slightly out of range, and confirmed in a follow-up test that it helped reduce LDL cholesterol.
- Started supplementing with nattokinase to naturally help reduce LDL cholesterol after a Function test showed his blood lipids were slightly out of range, and a follow-up test confirmed it worked.
- States that he started supplementing with nattokinase to naturally help reduce LDL cholesterol after learning his blood lipids were slightly out of range, and confirmed its effectiveness with a follow-up test.
- Started supplementing with nattokinase to naturally help reduce LDL cholesterol after learning their blood lipids were out of range, and a follow-up test confirmed its effectiveness.
Ben Greenfield · Nattokinase · neutral
- Questions the efficacy of nattokinase for plaque melting, asking how an enzyme can get through stomach acid and if the gut bacteria can utilize its chemical trash to make K.
- Notes there is good evidence that high-dose lumbrokinase and nattokinase from a specific source may help reduce or regress plaque, and he is looking into high-dose nattokinase as part of his damage control.
- Is glad that people are finally catching on to the idea of a high dose nattokinase protocol for heart health/plaque, emphasizing the importance of using adequate amounts, preferably more than 8000 units.
- Recommends nattokinase for plaque regression, stating that most supplements only have 1,000 to 2,000 units, but data shows an impact only at 8,000 units or more.
- Used to take nattokinase pills, but found the "earthy stuff" (fermented soybeans) to be more effective for shrinking plaque.
- Ben Greenfield recommends looking into nattokinase if concerned about plaque, noting its effect on coronary artery calcification.
- Ben Greenfield includes Nattokinase in his Vitaboom Heart Health Stack.
- Expresses skepticism about nattokinase for plaque melting, questioning how an enzyme can get through stomach acid and if it relies on specific gut bacteria to be effective, suggesting it's not a straightforward solution.
- Uses different types of enzymes like nattokinase to break open biofilms and hidden parasites so they can be killed off.
- Warns against combining nattokinase with pharmaceutical meds like a med, Pradaxa, a med, or a med, stating it could be potentially dangerous.
Dave Asprey · Nattokinase · recommends
- Recommends Nattokinase as one of the eight compounds in BioPurify for circulation and cellular health.
- Recommends Nattokinase, stating it supports healthy circulation and helps the body break down blood clots.
- Recommends taking nattokinase at night before bed on an empty stomach to help make a med, and notes it's also good for spike protein.
- Recommends taking high-dose nattokinase, starting at 12,000 units and potentially increasing to 20,000 units, to minimize the impact of the COVID vaccine, as it directly breaks up spike protein and reduces soft plaque.
- The episode discusses how nattokinase, a natural enzyme, has shown the ability to break down the spike protein.
- Nattokinase, an enzyme found in natto, breaks up protein clumps including blood clots, and studies show that at higher doses it can even reverse cardiovascular disease.
- For the last 25 years, Dave Asprey has been on a high dose of either serrapeptase or nattokinase to reduce stroke risk by breaking up thrombin and fibrinogen, also noting nattokinase breaks up soft plaque.
- Uses a lot of nattokinase and lumbrokinase to address histamine spike protein issues.
- Recommends nattokinase and other things to make blood flow well, especially for those with long COVID or who had COVID.
- Recommends nattokinase, stating that 4,000 units a day will likely break up clots from COVID and emerging research suggests it removes soft plaque, especially at higher doses on an empty stomach.
Dr. Eric Berg · Nattokinase · recommends
- Recommends Nattokinase as a top natural remedy for clots.
- Dr. Berg states that nattokinase, found in natto, is a very effective compound to reduce clotting.
- Recommends nattokinase as a supplement to prevent clotting.
- States that Nattokinase may help remove arterial plaque buildup naturally.
- Recommends Nattokinase, stating it can help decrease the thickness of the carotid wall.
- Has found Nattokinase really helpful, noting it may help break up clots.
- Recommends Nattokinase, an extract from soy, for dissolving fibrous tissue, breaking down clots, and addressing clogged arteries by breaking up blockages and protein formations in clots.
- Suggests that Nattokinase can potentially help lower cholesterol naturally.
- Recommends nattokinase as the best natural remedy to unclog arteries, noting it is an enzyme found in natto (fermented soybeans).
- Recommends Nattokinase as a potent remedy for unclogging arteries, noting its ability to break up clots, reduce oxidative LDL, provide anti-inflammatory properties, lower blood pressure, increase HDL, lower triglycerides, and decrease the risk of strokes, all with virtually no adverse effects.
Thomas DeLauer · Nattokinase · recommends
- Suggests increasing intake of nattokinase when in a fasted state to induce autophagy through a separate pathway from ghrelin, extending the autophagy period.
- Notes that nattokinase, a component of natto, may help clear out beta-amyloid plaque, which is a large contributor to Alzheimer's and dementia.
- Mentions that natto contains nattokinase, which helps clear out beta amyloid plaque, a primary contributor to Alzheimer's and dementia, noting the extremely low dementia count in Japan.
- Explains that nattokinase, a component of natto, may help clear out beta amyloid plaque, which is a large contributor to Alzheimer's and dementia.
Dr. Mark Hyman · Nattokinase · uses
- Uses nattokinase to break open bacterial biofilms, allowing antimicrobials to be more effective.
- Mentions using Nattokinase to lower lipoprotein little a, although it only lowers it by 20-30% and doesn't bring it back to normal.
- Recommends nattokinase for individuals with hypercoagulability to improve cognition.
- Mentions nattokinase as a natural supplement that can help thin blood and reduce inflammation and clotting.
- Mentions nattokinase as a natural supplement that can help thin blood and reduce inflammation and clotting.
- Uses nattokinase as a biofilm buster when a patient with candida is not getting better.
- Discusses Nattokinase as a great agent to help with clotting and microthrombosis, but notes it's in the experimental realm for the current virus.
Siim Land · Nattokinase · recommends
- Notes that some trials show nattokinase improving atherosclerotic plaque, with high doses showing an effect where low doses did not, and more studies are needed to find the threshold effect.
- Notes there are interesting studies suggesting Nattokinase might reduce atherosclerotic plaque and personally believes it does based on current evidence, but more clinical trials are needed to determine effective doses.
- Believes Nattokinase might reduce atherosclerotic plaque and blood viscosity, making it useful for people over 50, especially men, who have a higher risk of blood clotting.
- Discusses Nattokinase as a supplement.
- Recommends Nattokinase as a beneficial supplement for reducing atherosclerotic plaque and the risk of blood clots, suggesting a higher dose of 10,000 fibronotic units per day, but warns against taking it with meds.
- Cites a study where nattokinase at 6,000 fibrinolytic units per day for 26 weeks resulted in a 36.6% decrease in carotid plaque size and intima media thickness. He suggests that at least 6,000 fibrinolytic units per day might be needed for a significant decrease in plaque size, and also notes that nattokinase lowers blood pressure and clotting.
- Explains that Nattokinase, an enzyme from fermented soy, at a dose of 6,000 fibrinolytic units per day for 26 weeks, resulted in a 36.6% decrease in carotid plaque size.
- Plans to start taking Nattokinase after age 50, recommending a dose of at least 6,000 fibrinolytic units, and probably 10,000 units per day, for its benefits in heart health, cardiovascular disease risk reduction, and its antithrombotic, anti-blood coagulation, and anti-atherosclerotic effects.
- Uses Nattokinase as an ingredient in Novos Vital for organ health.
- Notes that there has been a lot of interest in nattokinase as an over-the-counter supplement that could potentially reverse plaque in the arteries.
Dr. Rhonda Patrick · Nattokinase · warns
- States that Nattokinase isn't high on their list for cardiovascular prevention and they don't see convincing evidence for it as a primary strategy for cardiovascular disease or stroke risk reduction.
- Dr. Rhonda Patrick reviews the evidence for nattokinase and its potential to protect the heart.
Peter Attia · Nattokinase · neutral
- Mentions Nattokinase as an over-the-counter supplement that showed more evidence for preventing DVT than a med, and it is plant-derived.
RAL Summary
Members OnlyTier 3 for Healthy Aging
Tier 3 because 86% of its 81 reviews are positive and animal studies give some support for nattokinase, though no human study has tested it for aging or cellular repair.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Circulatory system, Nervous system, Immune system, Kidneys, Liver
Combine with: Combine with a healthy diet and lifestyle.
Possible side effects: No major side effects reported.
Supplement Facts
Proprietary Blend 1030 mg · Nattokinase Complex 135 mg
| Proprietary Blend | 1,030 mg | † |
| Nattokinase Complex | 135 mg | † |
Other ingredients: Cellulose, Water, Tapioca Dextrin.
Directions: Suggested use. Take 3 capsules daily.
Barcode (UPC) 807735120948 · Label source: NIH label database · Report a label change
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Graded November 14, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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