Renue By Science Lipo Fisetin Review
Fisetin is a natural compound that supports healthy cells. LIPO Fisetin is designed to selectively target aging cells, fostering a clean and well-functioning internal environment. LIPO Fisetin is also available in our combination product, Senolytique. The product is listed as a 90 capsule supply with a serving size of one capsule, and the label lists Fisetin at 150 mg per serving. The product is sold under the Cellular Renewal byline and is marked as vegan and third-party tested. The page describes fisetin as a flavonoid and natural polyphenol and antioxidant found in strawberries, apples, onions, and other plants. It states that fisetin is particularly good at removing senescent or zombie cells, and it refers to fisetin as the king of senolytics. The page explains that senescent cells stop dividing, accumulate in the body, emit cytokines that trigger inflammation in neighbouring cells, and can impair cellular function and raise the risk of age-related conditions. To address the poor absorption and low bioavailability of standard fisetin, the page says LIPO Fisetin uses a liposomal delivery system designed to improve bioavailability and allow slower release into the bloodstream. It cites a study reporting that liposomal fisetin was shown to be 1.6 to 27 times more bioavailable. The page also explains that liposomes encapsulate active ingredients in a phospholipid bubble to protect them through the stomach and deliver them to tissues via the bloodstream. The FAQ section says that a larger share of a sublingual dose reaches the bloodstream with liposomal delivery, that liposomes protect the payload from degradation, and that powdered liposomal capsules release the payload slowly over up to 24 hours. It states that liposomal powder capsule products are not heat sensitive. The page lists a certificate of analysis with batch number 072827514, testing by Summit Nutritional Laboratories, and third-party certification documents. Brand statements say the products are non-GMO and free from preservatives, artificial colours, flavours and sweeteners, are tested in ISO-certified and cGMP-certified labs, and pass four rounds of testing. The page also notes that the product is allergen-free. It recommends pairing it with other Renue products such as NAD+ Complete, Quercetin, Energizer AM and Restore PM, based on complementary mechanisms. The page includes a disclaimer that its statements have not been evaluated by the Food and Drug Administration and that the product is not intended to diagnose, treat, cure or prevent any disease.
Study, Trial or Testing Result Summary
Members Only9 human studies · 7 improved
No study has tested fisetin for reversing aging in people, so the evidence here comes only from animals and lab work, and no human dose, including the 150 milligrams in this product, has been shown to work. In old mice, a single dose of fisetin reversed age-related changes in several blood proteins and tissue markers, especially in the kidney [1]. In obese mice, it reduced worn-out aging cells in fat tissue and improved blood sugar handling [2]. Old rats given fisetin for four weeks did better on thinking and behavior tests and had less oxidation damage [3]. In a mouse model of pregnancy-related heart failure, it reduced aging cells in the placenta and improved heart function [4]. The results are not all positive. In mice given a cancer drug, fisetin cleared aging cells from the ovaries but did not improve how the ovaries worked [5]. A large study in genetically varied mice found that fisetin in the diet did not extend lifespan in either sex [6]. Whether these animal findings apply to people taking this product is unknown. Animal and cell studies are never counted.
See all 9 studies →Hide the studies
- In lab cell experiments, fisetin worked together with chemotherapy to overcome resistance in tumor cells carrying a specific gene mutation linked to cell aging; the abstract does not report human dosing or outcomes for fisetin.eIF3a R803K mutation mediates chemotherapy resistance by inducing cellular senescence in small cell lung cancer.
- In a mouse model of pregnancy-related heart failure, fisetin given in late pregnancy reduced placental cell aging and improved heart function; the abstract reports no human dosing or outcomes for fisetin.Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human.
- In aged mice, a single acute dose of fisetin reversed age-related changes in several blood proteins and tissue markers, particularly in the kidney; the abstract gives no human dose or outcome for fisetin.IL-23R is a senescence-linked circulating and tissue biomarker of aging.
- Fisetin was identified as a drug that reduces aging-like changes (senescence) in immune B cells and improved the effect of immunotherapy in esophageal cancer in the study's experiments; the abstract gives no human dose or patient outcome for fisetin.Targeting senescent EGR1+ B cells enhances immunotherapy efficacy in esophageal squamous cell carcinoma.
- Aged rats given fisetin for four weeks showed better brain wave patterns, better thinking and behavior tests, and less oxidative stress than untreated aged rats.Fisetin prevents the aging-associated decline in relative spectral power of α, β and linked MUA in the cortex and behavi…
- In mice given doxorubicin, fisetin reduced senescent cells in the ovaries but did not improve ovarian dysfunction, apoptosis, or fibrosis.Increased cellular senescence in doxorubicin-induced murine ovarian injury: effect of senolytics.
- In genetically varied mice, fisetin given in the diet at the doses tested did not significantly change lifespan in either sex.Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumar…
- In aged mice, senolytic treatment including endothelial-targeted fisetin reduced a population of inflammatory heart macrophages; the abstract does not report a fisetin-specific functional outcome.Vascular Niches Are the Primary Hotspots in Cardiac Aging.
- In obese mice, fisetin reduced senescent endothelial cells in fat tissue and improved glucose metabolism.Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice.
Review Totals and Summary
Members Only100 reviews · 100% positive
Overall, buyers are positive about Renue By Science Lipo Fisetin capsules. The product carries about 43 ratings across the stores, and every starred review gives 4 or 5. The written feedback is short, mostly early impressions, and centres on the liposomal absorption, energy and mental clarity, and price. **What buyers say it did for them:** Some reviewers report a noticeable lift. One says it "makes me feel energetic without jittery nervousness" and felt energized from the first day. Another reports "sharper mental clarity." One buyer was prescribed it for a medical problem and, combined with other treatments, says it "seems t be working well." That is one person's experience. Others had taken it only a few days, so they say it is too early to judge. **What they complain about:** The only criticism is cost. One reviewer calls it "a bit expensive," though they still recommend it. No reviewer mentions side effects, packaging, or problems with the product itself. **Taste, smell, pill size, form:** Nobody comments on taste, smell, or capsule size. The form is discussed only in terms of the liposomal delivery. Reviewers like that it "gets past your digestive juices" and say bioavailability without the liposomal treatment is very poor. This is the main reason given for choosing it. The store summaries also cover only the capsule reviews, and I left out other forms of the product. **Value for money:** Opinions on price depend on what buyers compare it with. One thought it pricey but worth it because of the liposomal form. Another found it a relief after a German retailer's price was "insanely expensive." Shipping is praised as very quick. One buyer bought two more bottles after about two weeks of use, which suggests some repeat interest. **Who it seems to suit and who it did not:** It appears to suit people who already know fisetin and want a form designed for better absorption. It also suits those who want a boost in energy or focus without feeling jittery. One reviewer is 74 and says they can feel a difference compared with before taking it. Anyone who wants the cheapest fisetin may find the price a hurdle. Nobody reports that it did not work for them. However, the written feedback is thin, mostly from the first days or weeks of use, and gives little on long-term results.
Biohacker Summary
Members Only6 of 10 recommend it
Six of the ten panelists spoke about fisetin, and they are split. Three use or recommend it, mainly to clear old, worn-out cells that build up with age, and one of them also named it as a pro Nrf2 compound. Two warn that the strong results in animals have not been backed by human trials, and one of those said his own mouse study found no effect on lifespan or on those old cells. Doses mentioned were 500 milligrams during a water fast alongside quercetin, 500 to 1000 milligrams, and 100 milligrams once a month for three days, with a short course of four or five days also described. One panelist noted that fisetin is poorly absorbed and costly, which is why larger doses are needed, and another rated it only okay for now because of the lack of human data.
See all 6 biohackers →Hide the biohackers
Siim Land · Fisetin · neutral
- Mentions fisetin as a phytochemical that has been shown to stimulate GLP-1 expression directly, and also increase glucose uptake and insulin sensitivity.
- Notes that Fisetin has yielded the biggest life extension effects in animals, but there are no human clinical trials on senolytics yet.
- Mentions that Fisetin has been shown to extend lifespan in animals, but human evidence is limited and it is quite expensive, placing it in the 'okay' tier for now due to lack of human data.
- Mentions fisetin as a senolytic compound that helps eliminate senescent cells, which accumulate during aging and spread inflammation.
- The absorption rate for fisetin is around 1-3%, which is even lower than pure PCC1, explaining why much bigger doses are needed.
- Places Fisetin in the 'okay tier' for longevity, grouping it with other senolytics, stating that while it works to inhibit senescent cells and reduces them in humans, the actual outcomes and optimal protocols for its use are not yet clear from human data.
- Siim Land, who takes fisetin intermittently, notes that it has senolytic activity but requires high doses to see a benefit in mice and that the optimal human dose is unknown.
- Used to take fisetin in the past but no longer does, as he has already tested most supplements.
- States that Fisetin has been shown to extend lifespan in animals, but human evidence is limited and it is quite expensive. He places it in the 'okay tier', noting it could rise in ranking with more human study data.
- Found fisetin while researching senolytics for detoxing zombie cells.
Ben Greenfield · Fisetin · uses
- Mentions Fisetin as an extremely amazing ingredient that has surpassed Astaxanthin in anti-aging efficacy.
- Started researching Fisetin after learning about senolytics.
- Started researching fisetin after learning about senolytics.
- Mentions fisetin as one of the polyphenols included in the IM8Health formula.
- Mentions fisetin as one of the compounds included in IM8 Health, which supports cellular repair, gut function, and high-level energy output.
- Julie started researching fisetin after learning about senolytics, as it is an ingredient that helps detox zombie cells.
- Mentions fisetin as an example of a senolytic agent that helps get rid of senescent cells.
- Mentions fisetin as an ingredient in the NOVOS supplement, which has decent human research for cellular longevity and staving off DNA damage.
- Mentions fisetin as an evidence-backed senolytic molecule that helps the body naturally eliminate senescent cells.
- Lists fisetin as a substance that can help remove senescent cells.
Dave Asprey · Fisetin · warns
- Dave Asprey expresses a strong desire for senolytics and fisetin to work for longevity by clearing senescent cells, but classifies them as F tier due to spectacular animal data not yet being supported by real human trials.
- Recommends supplements like fisetin for next-level cellular support.
- Uses Fisetin for longevity, stating it helps the body get rid of old cells.
- Recommends taking things like fisetin, which comes from strawberries, as a senolytic to treat zombie cells.
- Suggests that taking 500 milligrams of fisetin during a water fast, along with quercetin, will lead to more autophagy.
- Recommends using fisetin for autophagy, going hard for a period of time and then going to a very maintenance level.
- Mentions fisetin, found in strawberries, as an example of an ingredient that can raise PGC-1 alpha.
- Recommends Fisetin for allowing the aging immune system to become more youthful and functional, and also for making the brain work better and for anti-aging purposes.
- Uses fisetin transmucosally, noting its poor oral absorption, and takes it twice a week during partial fasts to activate autophagy, before bed and upon waking.
- Mentions using fisetin.
Dr. Mark Hyman · Fisetin · uses
- Is interested in her senescent cell load and uses fisetin, a simple supplement from berries, which a researcher she works with has measured to decrease the load.
- Recommends fisetin, derived from strawberries, as part of a 4 or 5-day senolytic intervention to kill zombie cells and lower the burden of toxic, pro-inflammatory cells.
- Takes Fisetin as one of the more interesting supplements for aging.
- Likes Fisetin, taking 500 to 1000 milligrams, noting it kills zombie cells, stimulates autophagy, and activates sirtuins and AMPK, which are longevity switches.
- Mentions that fisetin, a phytochemical derivative from strawberries, can kill zombie cells.
- Mentions fisetin, found in strawberries, as a phytochemical that kills zombie cells.
- Mentions that fisetin, a phytochemical derivative from strawberries, can kill zombie cells.
- Mentions fisetin, found in strawberries, as a phytochemical that affects longevity pathways.
- Recommends fisetin, found in strawberries and other foods, as a phytochemical good for longevity.
- States that fisetin, found in strawberries, persimmons, apples, cucumbers, and onions, is a very powerful senolytic and is part of his daily regimen.
Peter Attia · Fisetin · warns
- States that Fisetin, an allegedly senolytic drug, had no beneficial effect whatsoever in mice and no changes in senescent cells were observed with multiple markers. He notes that despite this, the drug is being marketed in clinical trials and as a natural product.
- Discusses Fisetin, which is undergoing human trials as a senolytic drug, but states that in their mouse study, it had no effect on lifespan and did not remove senescent cells at the tested dosages.
- Peter Attia's lab found that Fisetin had no effect whatsoever on the lifespan of male or female mice using either of the dosage regimes that Dr Kirkland recommended, and it didn't remove any senescent cells either. He states that Fisetin "doesn't do jack" in their studies.
- Takes 100 mg of Fisetin once a month for 3 days for longevity.
Dr. Eric Berg · Fisetin · recommends
- Lists fisetin, a phytonutrient found in strawberries, onions, and cucumbers, as a pro Nrf2 compound.
RAL Summary
Members OnlyTier 4 for Healthy Aging
The 100 counted reviews do not match the review summary, which reports only about 43 capsule ratings and says other forms of the product were left out, so the count likely includes reviews of other forms rather than this product. Its reviews are set aside, so it is graded on its studies alone. Animal studies support Fisetin, but there are not yet enough reviews to confirm it (0).
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 1 of the 9 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Kidneys, Metabolism, Nervous system, Reproductive system, Heart and blood vessels
Combine with: Fisetin is a flavonoid studied as a senolytic, meaning it may help clear senescent cells, and it also has antioxidant and anti-inflammatory activity. It pairs well with other longevity-oriented compounds. Quercetin is a classic senolytic partner (as in a med+quercetin research), and the two may work together. NAD+ precursors such as NMN or nicotinamide riboside support mitochondrial function and sirtuin-driven DNA repair. Trans-resveratrol, taken with a fat source, and pterostilbene support sirtuin and antioxidant pathways. Other options include spermidine for autophagy support, alpha-lipoic acid and CoQ10 or PQQ for mitochondrial support, and omega-3s for inflammation balance. Fisetin is often dosed intermittently (for example a few consecutive days per month) in senolytic protocols, while NAD+ precursors and resveratrol are taken daily. Because fisetin may have mild blood-thinning effects, check with a healthcare provider if you take meds or have upcoming surgery.
Possible side effects: No major side effects reported.
Supplement Facts
Fisetin 150 mg
| Fisetin | 150 mg | † |
Other ingredients: Cellulose, Sunflower Lecithin, Rice Flour, Microcrystalline Cellulose.
Directions: Suggested Use Take one (1) capsule daily with or without food. May be taken with or without food.
Barcode (UPC) 656165996742 · Label source: NIH label database · Report a label change
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Graded November 4, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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