Smarter Nutrition Enzymes Review
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Study, Trial or Testing Result Summary
Members OnlyHuman studies
No human study has tested this product or its ingredients for slowing aging or repairing cells and DNA. The main ingredient, a 350 milligram enzyme blend, has no studies for this goal at all. The second ingredient, AstraGin at 25 milligrams, is a branded mix that includes Astragalus, but no study tested AstraGin itself, and its studied dose is unclear. The only related research is in animals using other Astragalus extracts. In pigs fed wolfberry and Astragalus extract for 90 days, liver antioxidant enzymes rose, but a marker of cell damage did not change [1]. In mice and rat brain cells, Astragalus combined with another plant compound reduced brain damage after a stroke-like loss of blood flow and protected the cells' energy-producing parts [2]. In newborn mice with brain injury from lack of oxygen, a different Astragalus extract raised a cell-repair enzyme and reduced nerve cell death [3]. In mice on a high-fat diet, Astragalus extract lowered liver fat, cell damage and inflammation signals [4]. None of these studies measured biological age or used this product, so they say little about what it does in people. Animal and cell studies are never counted.
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Review Totals and Summary
Members Only509 reviews · 78% positive
Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.
Biohacker Summary
Members Only0 of 10 recommend it
The main ingredient, AstraGin, was discussed by three of the ten panelists, and all three use it. One takes it as part of a blend to improve absorption and gut balance, one takes 1 gram in the morning for longevity, and one takes it daily for gut health. Nobody on the panel voiced a caution or said they stopped taking it, but only three people spoke about it, so the picture is thin. Enzymes are a smaller ingredient in this product, and most of the panel who discussed them recommend or use them, mainly to help digest protein and heal the gut, though one advised against making them a daily habit and another would not recommend taking a bunch for digestion.
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Ben Greenfield · AstraGin · uses
- Uses AstraGin® as part of NAD Regen to improve absorption and gut balance.
- Mentions supporting gut health with toxin-free toilet paper, supplements like TUDCA, enzymes, magnesium, mindful hydration, and detox strategies for overall digestive wellness.
- Recommends using proteolytic enzymes in steady dosages and pulsing them to break off the viruses' coating for Epstein-Barr.
- Is a big fan of enzymes for blood thinning and personally uses lumbrokinase.
- Gut enzymes are mentioned as part of jet lag hacking.
- Ben takes gluten polypeptide ace enzymes to knock out gluten when eating meals that are not gluten-free.
- Explains that enzymes break down fibrinogen, which causes soreness after a workout, and combining them with other ingredients creates a potent formula for knocking out inflammation.
- Suggests that more enzymes and hydrochloric acid are needed to support digestion, as enzymes alone are not enough without the power of HCL.
- Mentions that BiOptimizers makes enzymes to digest proteins and that these enzymes can also be used for soreness by taking them on an empty stomach.
- Recommends using digestive enzymes and bitters before eating to help the body produce more stomach acid and digestive enzymes.
- Emphasizes the crucial role of enzymes, stating that they make life possible, detoxify, and are essential for digestion, which is a main reason for eating meat, chicken, and dairy raw.
Siim Land · AstraGin · uses
- Takes 1 gram of AstraGin from DoNotAge in the morning for longevity.
- Suggests using enzymes to break the thermodynamically stable bonds caused by glycation, as enzymes have extraordinary specificity and can be reactive without causing side effects.
- States that enzymes are great.
- Believes enzymes are one of the two most important nutrients to consume for any diet because they break down food into usable components and perform 25,000 different functions in the body.
Andrew Huberman · AstraGin · uses
- He takes AstraGin daily from Momentous for gut health.
Dave Asprey · Enzymes · uses
- Tested enzymes with European soft wheat and slow-ferment sourdough for 6 months and found it works, but advises not to make it a daily habit to protect the gut barrier.
- Takes some enzymes to help tolerate European wheat, although he notes it's still not good for him.
- Suggests taking enzymes to absorb a large amount of protein.
- Takes enzymes to help absorb 100 grams of protein per meal, as he believes he would get "bodybuilder farts" otherwise.
- Always takes enzymes with his protein to aid absorption and prevent metabolic issues from too much protein.
- Recommends taking enzymes with protein to ensure proper absorption and prevent issues like ammonia production from undigested protein.
- Takes enzymes when she eats to aid digestion.
- Discusses enzymes as catalysts for biochemical reactions in the body, essential for breaking down food and involved in various bodily functions from thinking to blinking.
- Recommends taking systemic enzymes, specifically mentioning those formulated by Wade for BiOptimizers, during fasting to accelerate benefits like breaking down scar tissue and old cells.
- Dave Asprey and his friend tried a massive amount of enzymes for 90 days and both transformed, gaining muscle, losing fat, and improving skin and brain function. He believes enzymes helped with weight, especially as a vegetarian bodybuilder, because vegetarian protein is difficult to break down.
Dr. Mark Hyman · Enzymes · recommends
- Recommends replacing missing enzymes as part of the 5R program for gut health.
- Emphasizes the importance of digestive enzymes, an old naturopathic concept that now makes total sense for gut health, contrasting it with the limited focus of gastroenterologists.
- Gave a patient enzymes to help heal the gut.
- Recommends using enzymes to help with gut repair.
- States that they aggressively treat the gut with enzymes.
- Dr. Hyman used enzymes to help repair the gut of a patient.
Thomas DeLauer · Enzymes · neutral
- Notes that Sun Warrior's active protein line includes enzymes to help with protein availability.
- Notes that Sun Warrior's protein powder is combined with probiotics and enzymes to help with the digestion aspect.
- Would not necessarily recommend taking a bunch of enzymes for digestion.
- Recommends adding some enzymes on high protein low fat days due to the high protein intake.
Dr. Eric Berg · Enzymes · recommends
- Suggests that one might need more enzymes if the pancreas is too exhausted due to the constant introduction of carbohydrates, which can contribute to constipation.
- Suggests taking enzymes for food intolerances like lactose intolerance or gluten intolerance to help with gas and bloating.
- Recommends taking a supplement with a wide variety of enzymes if bloating is accompanied by diarrhea or floating, greasy stool, indicating a lack of pancreatic enzymes.
- Explains that enzymes, produced by the pancreas and small intestine, are crucial for digestion in the small intestine, and a deficiency can lead to constipation; they recommend eating raw foods that have enzymes.
- Notes that enzymes are needed to break down food and extract micronutrients.
- Dr. Berg lists enzymes used in cheese as something that could make a GMO.
- Dr. Berg recommends taking Enzymes before the meal.
- Suggests that many people do better when they take enzymes, as they aid in the breakdown of protein, especially if there are issues with the pancreas or stomach acid.
- Recommends taking enzymes just before eating.
- Explains that the pancreas produces most of the body's enzymes, which are essential for breaking down food particles; a lack of enzymes, often due to consuming wrong foods or insulin resistance, leads to undigested food, bloating, and gas.
Peter Attia · Enzymes · recommends
- Recommends replacing missing elements for gut health with enzymes to support the system, which can be through food or supplements.
RAL Summary
Members OnlyTier 4 for Healthy Aging
Tier 3 rests on animal studies of other Astragalus extracts and herb combinations, not on AstraGin or the main enzyme blend, so there is no real study support for this product and the evidence is thin. So it is graded Tier 4, lower than the rules alone gave.
- Emerging: not enough evidence to rank higher yet.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Digestive system
Combine with: Combine with a healthy diet and lifestyle.
Possible side effects: No major side effects reported.
Supplement Facts
Smarter Enzymes Blend 350 mg · AstraGin 25 mg
| Smarter Enzymes Blend | 350 mg | † |
| AstraGin | 25 mg | † |
Other ingredients: Vegetarian Capsule, organic Rice Bran, organic Nu-Flow, organic Rice extract.
Directions: Suggested use: Adults take 1-2 capsules directly after each meal, or as recommended by your healthcare provider.
Barcode (UPC) 857917007130 · Label source: NIH label database · Report a label change
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- NAD Anti-Aging Supplements: Benefits, Evidence, and How to ChooseArticle · Jun 15, 2026
Graded November 10, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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