SuperSmart Akkermansia Muciniphila 1 Billion Cells Review
Our Akkermansia Muciniphila supplement is a probiotic offering 1 billion pasteurized cells per capsule. The page describes it as a probiotic formula featuring pasteurized Akkermansia muciniphila to help support gut lining and metabolic wellness. Each capsule contains 1 billion TFUs of pasteurized Akkermansia muciniphila, and the label is presented as a formula that may help maintain a balanced gut environment and support metabolic markers related to body composition. The product is positioned for those seeking potential targeted microbiome support during weight-conscious lifestyles. The page notes that the label recently changed its graphic design, but that the composition has remained strictly the same. It is delivered in delayed-release capsules, which the page says are designed to help protect bacterial viability through the digestive tract. The bottle contains 60 gastro-resistant capsules, with a serving size of one capsule taken once per day. The supplement facts list Akkermansia Muciniphila AH39 at 10 mg, equal to 1 Billion TFU per capsule. Other ingredients are a vegetable capsule (hypromellose), acacia gum, and white rice flour. The page states the product is gluten-free, vegetarian, free of controversial excipients, additive-free, GMO-free, and made with controlled raw materials. Storage guidance says it is better kept refrigerated, and the warnings advise adults only, not to exceed the daily dose, and to consult a healthcare provider if pregnant, breastfeeding, or having health concerns. The page explains that Akkermansia muciniphila is a naturally occurring gut bacterium first identified in 2004, believed to be one of the earliest colonizers of the gut and representing close to 1% of the intestinal microbiota. It is described as using mucins, proteins in the protective mucus layer, as its primary energy source. Some studies are cited as suggesting links to healthy gut function, and early findings are said to indicate interaction with receptors in the intestinal lining that may support gut barrier integrity. The page also says that higher abundance may be associated with balanced waist circumference. All statements are marked as not evaluated by the FDA and the product is not intended to diagnose, treat, cure, or prevent any disease. The product is part of the Weight Management category and is sold as a one-time purchase or on a Subscribe and Save option.
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Study, Trial or Testing Result Summary
Members Only8 human studies · 4 improved
For blood sugar, the research on Akkermansia is mixed. The newest and largest trial, in 142 adults with metabolic syndrome, found that 4 months of pasteurized Akkermansia did not improve whole-body insulin sensitivity more than a placebo, though it did help people with prediabetes and those with low starting levels of Akkermansia in the gut [1]. A 12-week trial in 58 overweight people with type 2 diabetes found no overall drop in the long-term blood sugar marker versus placebo, with a benefit only in people with low starting Akkermansia [2]. An earlier, smaller trial in 40 insulin-resistant adults reported about 29 percent better insulin sensitivity and 34 percent lower insulin after 3 months [3]. A trial in 76 people with diabetes found lower blood sugar, but it used a five-strain blend, so the effect cannot be credited to Akkermansia alone [4]. An 8-week yogurt trial in 66 adults reported no blood sugar benefit [5]. A review of trials in women with polycystic ovary syndrome included only one Akkermansia trial, so it says little about this ingredient [6]. The studies did not state a dose that can be compared with this product's 10 milligrams, so whether it matches the studied amount is unclear. Animal and cell studies are never counted.
See all 8 studies →Hide the studies
- Across 17 trials in 1,214 women with polycystic ovary syndrome, gut-metabolite treatments (only one trial used Akkermansia) lowered fasting insulin and insulin resistance, but results were not specific to Akkermansia.Effect of probiotic-derived metabolites on hormonal and metabolic profiles in women with polycystic ovary syndrome: a sy…
- In 142 adults with metabolic syndrome, 4 months of pasteurized Akkermansia did not improve whole-body insulin sensitivity over placebo overall, but helped in prediabetic subgroups and in people with low baseline Akkermansia.Effect of pasteurized Akkermansia muciniphila MucT on insulin sensitivity, body composition, and GLP-1 production in sub…
- In 76 people with type 2 diabetes, 12 weeks of a five-strain blend containing Akkermansia lowered after-meal blood sugar and HbA1c by 0.6 compared with placebo.Improvements to postprandial glucose control in subjects with type 2 diabetes: a multicenter, double blind, randomized p…
- In 66 overweight or obese adults, 8 weeks of Akkermansia postbiotic yogurt reduced waist size, body fat and a liver enzyme versus control, with no blood sugar benefit reported.Comparing the effects of yogurt containing Akkermansia muciniphilia postbiotic with yogurt containing Lactobacillus rham…
- In 58 overweight or obese people with type 2 diabetes, 12 weeks of Akkermansia did not lower HbA1c more than placebo overall, but did in those with low baseline gut Akkermansia.Akkermansia muciniphila supplementation in patients with overweight/obese type 2 diabetes: Efficacy depends on its basel…
- In 40 overweight or obese insulin-resistant adults (32 finished), 3 months of pasteurized Akkermansia improved insulin sensitivity by about 29% and lowered insulin by 34% and total cholesterol by 9% versus placebo.Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory st…
- In insulin-resistant adults with metabolic syndrome, Akkermansia changed blood amino acid and fat-burning metabolites, but the abstract reports no blood sugar results.Serum metabolite profiling yields insights into health promoting effect of A. muciniphila in human volunteers with a met…
- In a mouse study (not human), Akkermansia muciniphila HHAKKα given by mouth for 8 weeks on a high-fat diet limited weight gain, helped maintain blood sugar control, lowered blood triglycerides and LDL cholesterol, and reduced inflammatory cytokines.Akkermansia muciniphila HHAKKα Prevents High-Fat Diet-Induced Obesity in Mice via Gut Microbiota Modulation and Regulati…
Review Totals and Summary
Members Only1 reviews · 100% positive
SuperSmart's page for Akkermansia Muciniphila 1 Billion Cells shows 1 rating in total, and the themes below come from the single written review that could be read there. Because only one review exists, no broad pattern of customer feedback can be drawn, and everything here rests on that one entry. The reviewer, Larry, gave five stars and the one-line title "Excellent," dated January 11, 2025. This is the only praise on the page, and it is a general endorsement rather than a description of specific benefits. The page's headline rating is five out of five stars. The star breakdown shows 100 percent of ratings at five stars and zero percent at four, three, two and one star. Since this is based on one rating, it carries very little weight. The only substantive theme is why the buyer purchased. The written comment says the reviewer is trying the product for digestive issues. So the one thing we can say about who it seems to suit is that at least one buyer chose it hoping to help with digestive concerns. The review does not say whether it worked, so no claim about results can be made. No complaints appear in the written feedback. That should not be read as evidence of a problem-free product, only as the absence of any negative comment in a single short review. Several things buyers often want to know are not covered. The review does not mention taste, capsule size, ease of swallowing, or any aftertaste. It says nothing about value for money, dosage experience, tolerability, long-term use, or repeat purchase. Because there is only one entry, no comparison across time is possible. Prospective buyers would learn little about the product's effects from this page alone. The reviews section includes a "Read reviews" link and an anchor to the reviews area, but no further written comments are displayed. The page also lists other products, such as Lactobacillus Reuteri and Full Spectrum Probiotic Formula, with their own review counts. Those belong to different items and are not part of this product's feedback, so they were left out. No reviews of other forms of Akkermansia, such as gummies or powder, appeared in the material, so nothing needed to be excluded on that front, and this summary concerns the capsules only. In short, the written evidence is very small: one five-star review from a buyer trying the capsules for digestive issues, with no reported complaints and no detail on outcomes, taste, or form. Any broader conclusion about customer satisfaction would go beyond what the text shows, so this should be treated as a starting point rather than a verdict on the product.
Biohacker Summary
Members Only4 of 10 recommend it
The panel is split on Akkermansia muciniphila, with only a few clear recommendations and several who stay neutral. Two of them recommend it, one pointing to a new microbiome product built around it and the other saying it supports blood sugar and the gut lining, and a few more say they take it or that practitioners use it for people who test low. Their reasons are gut barrier strength, metabolic health and blood sugar control, with one adding that it may help with appetite and carb cravings. Two panelists warn that it can eat away at the gut lining when fiber or carbs are low, one cites worries about colon cancer from early data, and another says taking the bacteria may not raise gut levels at all. One stopped a probiotic containing it and saw his levels drop, and several prefer to feed it with polyphenol foods such as pomegranate, berries, green tea and cranberry or with prebiotic fibers, while no one gave a dose.
See all 10 biohackers →Hide the biohackers
Thomas DeLauer · Akkermansia muciniphila · warns
- Warns that elevated Akkermansia levels in conjunction with low-fiber diets can increase the likelihood of type 2 diabetes, as Akkermansia will eat the gut lining without other food sources.
- Expresses caution about Akkermansia supplementation, noting its interesting biology for metabolic health but highlighting cross-sectional data linking it to higher amounts in colon cancer patients and a preclinical mouse study where supplementation led to colon cancer, urging for more long-term data.
- Mentions Akkermansia as a molecule relevant to VO2 Max and endurance performance, noting it tends to be higher in endurance-trained individuals.
Dave Asprey · Akkermansia muciniphila · recommends
- Recommends taking Akkermansia directly as a supplement to restore its levels, which can raise insulin sensitivity by 28% over three months by maintaining the lining of the intestines.
- Dave Asprey mentions how Akkermansia improves mitochondrial function and blood sugar control.
- Notes that even when patients take Akkermansia products, they often show no detectable Akkermansia in their gut or no production of short-chain fatty acids like butyrate, indicating that simply taking the bacteria is not enough.
- Warns that if there aren't enough carbs to make mucus lining for the gut, Akkermansia can poke holes in the gut and is associated with Parkinson's.
- States that he takes Akkermansia because he believes that if you have a healthy gut lining, it is beneficial for controlling blood sugar.
- Warns that Akkermansia muciniphila, while considered a probiotic, is a primary reason for multiple sclerosis and other gut lining diseases, especially if not fed during long fasts, as it will eat the mucin layer.
- Thinks Akkermansia would be a meaningful addition to a med protocol, as it helps with GLP-1 levels.
- States that Akkermansia is super important because it plays roles in strengthening the gut lining and sugar regulation, and notes that dermatologists are using it for conditions like atopic dermatitis and eczema.
- Dave Asprey takes Akkermansia as a probiotic due to its viable case for reducing blood sugar.
- Identifies Akkermansia as an important gut bug that helps metabolize sugars and plays a fundamental role in the microbiome, especially in glucose control, inflammation, immune response, GI distress, and the gut-brain connection.
Bryan Johnson · Akkermansia muciniphila · recommends
- Launched a new product for a healthy microbiome, built around Akkermansia muciniphila, a keystone bacterium that decreases with age and is linked to metabolic health.
Ben Greenfield · Akkermansia muciniphila · stopped
- Ben Greenfield's Akkermansia decreased after FMT, which Ben Greenfield attributes to having stopped taking a Pendulum probiotic that contained a great deal of Akkermansia.
- Mentions that Akkermansia, an ancient bacteria that helps with gut barrier strength and fighting metabolic issues, persisted even after stopping a wild-type diet.
- Discusses Akkermansia muciniphila as the only known bacterial strain that directly stimulates GLP-1 production and plays a core role in regulating the gut lining, with low levels correlated to various diseases.
- Mentions Akkermansia as something that can mimic or trigger GLP-1, potentially helping with appetite cravings and carb control.
- Ben Greenfield thinks it is prudent to supplement with an Akkermansia based probiotic if one is using ozone regularly, either rectally or orally, to prevent decimating some of the anaerobic bacterial population.
- Ben Greenfield mentions Pendulum, a company using a GLP-1 based probiotic with Akkermansia to potentially trigger L cells and induce satiety.
- Will discuss the relationship between gut bacteria like Akkermansia and butyrate production, and how probiotic strains work synergistically to support GLP-1 release and metabolic health.
- Warns against supplementing with Akkermansia alone, as it needs to exist in balance with other bacteria like bifido, and supplementing it can throw off the balance and cause more problems.
- Has tried an Akkermansia based supplement in the morning and felt very satiated, making breakfast feel like an option rather than a necessity. He mentions Pendulum makes a good one called GLP-1.
- Recommends the Pendulum GLP-1 Probiotic, explaining that it operates on the microbiome level by increasing akkermansia and bifidobacterium to enhance satiety and fullness.
Dr. Mark Hyman · Akkermansia muciniphila · neutral
- Akkermansia is a very important bacteria that can easily be killed by meds, and it coats the lining of the intestine, protecting against food, proteins, and bacteria leaking in and causing inflammation.
- Identifies Akkermansia muciniphila as a keystone species that brings order to the gut ecosystem, noting that his own low levels during colitis were restored by taking pomegranate, green tea, and cranberry.
- States that Akkermansia has been shown for cognitive support and produces Gaba, and people are often deficient in it.
- Mentions that Akkermansia muciniphila is a good friend of his and that he lost it when he was sick with ulcerative colitis, but was able to grow it back using food polyphenols.
- Takes Akkermansia muciniphila, a guardian gut bacteria, noting that research shows it can triple the amount in the gut and is often low in sick patients.
- Notes that Akkermansia bacteria, which is important for many reasons, actually produces GABA, acting like a natural a med.
- Used pomegranate, green tea, and cranberries to increase levels of Akkermansia muciniphila, a bacteria critical for preventing leaky gut, which helped heal their gut from autoimmune disease.
- Recommends promoting the growth of Akkermansia bacteria in the gut, as it acts as a conductor of metabolism, body fat regulation, glucose homeostasis, immune function, and inflammation, and is often found in lower levels in heavier individuals.
- Discusses a case where a patient with stage four uterine cancer had low Akkermansia, which prevented her from responding to immunotherapy. After boosting her Akkermansia with polyphenols, she was cured of cancer when immunotherapy was administered again.
- Discusses Akkermansia as a keystone microbe that protects the gut lining, prevents leaky gut and inflammation, regulates immunity, and produces high levels of GABA, an anti-anxiety neurotransmitter.
Dr. Eric Berg · Akkermansia muciniphila · neutral
- Explains that a deficiency in Akkermansia, found in 40 to 60% of the population, leads to an inability to produce the mucus barrier, increasing the risk of metabolic syndrome and obesity.
Peter Attia · Akkermansia muciniphila · neutral
- Peter discusses the potential therapeutic uses of Akkermansia for gut health from the Colleen Cutcliffe episode.
- Sells a product that is just pure Akkermansia, which is one of their best sellers, and many practitioners use it to boost this strain back up in people who are low in Akkermansia based on gut microbiome tests.
Siim Land · Akkermansia muciniphila · neutral
- Notes that Pendulum Akkermansia is a probiotic.
- Recommends beneficial Akkermansia, obtained from polyphenol-rich berries and prebiotic fibers like artichoke, for benefiting metabolic health and weight loss.
- Recommends feeding Akkermansia, which is difficult to feed directly, with pomegranate, apple skins (anthocyanins), alpha-3 galactoside, and indirectly through human milk oligosaccharides.
Andrew Huberman · Akkermansia muciniphila · neutral
- Huberman explains that Akkermansia muciniphila is a mucus-loving bacterium whose main function is to eat mucus in the gut.
Dr. Rhonda Patrick · Akkermansia muciniphila · neutral
- Dr. Rhonda Patrick discusses Akkermansia muciniphila.
RAL Summary
Members OnlyTier 4 for Blood Sugar
Some trials show better insulin sensitivity, but the newest and largest trials found no overall blood sugar benefit, and there is only one customer rating, so the evidence remains emerging [1][3].
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 1 of the 8 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Digestive system, Endocrine system, Metabolic system
Combine with: To support metabolic and gut-barrier goals, pair Akkermansia with polyphenols that feed it, such as pomegranate extract (ellagic acid), cranberry extract, or grape seed extract, along with prebiotic fibers like inulin or partially hydrolyzed guar gum. Berberine or chromium can add glucose-handling support, and omega-3 fish oil may help reduce inflammation and support mucus layer health. If the user truly wants cellular and DNA repair support, they would need separate agents with direct evidence: NMN or NR (NAD+ precursors) with TMG, resveratrol or pterostilbene, quercetin and fisetin (senolytic candidates), and CoQ10 or PQQ for mitochondrial support. Take Akkermansia with a meal or as directed, and consult a healthcare provider if immunocompromised or on meds.
Possible side effects: No major side effects reported.
Supplement Facts
Akkermansia muciniphila AH39 10 mg
| Akkermansia muciniphila AH39 | 10 mg | † |
Other ingredients: Acacia Gum, White Rice Flour.
Directions: Recommended use: Adults. Take 1 capsule per day.
Barcode (UPC) 05453003828303 · Label source: NIH label database · Report a label change
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- How to Lower Blood Sugar Naturally: A Comprehensive GuideArticle · Sep 9, 2026
- Intermittent Fasting: What the Human Trials Show for Weight, Blood Sugar and AgingArticle · Oct 29, 2026
Graded November 4, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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