Thorne Amino Complex - Travel Packs - Lemon Review

Thorne Amino Complex - Travel Packs - Lemon is a lemon-flavored stick pack of essential amino acids (EAAs) and branched-chain amino acids (BCAAs). Each packet is one serving, and the container holds 30 packets. The page says the formula is clinically validated and supports the growth of lean muscle mass, muscle strength, and recovery after exercise. It also says the formula helps reduce muscle soreness from training and supports cellular energy production and healthy blood sugar already within the normal range. The directions say to mix one stick pack with at least eight ounces of water and to take one to two times daily, or as recommended by a health-care practitioner. The page recommends taking it after a workout to support recovery. It mixes easily in warm or cold liquid. The product is lightly sweetened, vegan, gluten free, dairy free, and soy free, and it is NSF Certified for Sport. The page explains that EAAs are amino acids the body cannot make itself, and that they fuel muscle gain and other functions such as enzyme production and energy metabolism. It describes the product as useful for athletes, older adults who need to preserve muscle mass, people recovering from muscle injury, and anyone who has trouble eating whole foods or protein powders. The warnings section lists a California Proposition 65 lead warning, advises that pregnant or nursing people should not use the product, and states that New York law prohibits sale to people under eighteen. The page also lists a Berry flavor as a separate product.

Tier ⓘ
Tier 4
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
49 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
60% of 51
Biohacker Mentions
10 of 10
Cost per month
$56

Study, Trial or Testing Result Summary

Members Only113 human studies · 48 improved

5 of these 113 human studies gave the ingredient by drip, not by mouth.

113 human studies48 improved32 no effect26,516 people studied

This product mixes essential amino acids, led by leucine, lysine, isoleucine and valine at doses near those used in studies. Leucine-rich protein supplements improved muscle strength, mass and performance in older adults with age-related muscle loss [1]. A leucine and vitamin D enriched whey drink added a little muscle and improved chair-stand performance, but not grip strength [2]. A larger pooled analysis also found gains, though the evidence was rated low quality [3]. Leucine on its own, without protein, mostly did not help, both in frail older adults doing strength training [4] and in midlife women [5][6]. Lysine's support comes mainly from mixes that also contained other compounds, so its own role is unclear [7][8]. Isoleucine and valine were only tested inside three-amino-acid mixes, with mixed results. Some trials found small lean mass gains [9][10]. Others found no added muscle or strength [11][12][13]. The remaining amino acids are at small doses with no clear studied dose. In one small trial, an amino acid drink with threonine, phenylalanine and methionine added nothing to strength training in older men [14]. Animal and cell studies are never counted.

See all 113 studies →Hide the studies

Review Totals and Summary

Members Only51 reviews · 60% positive
51 reviews · Thorne 49 · Amazon 2
60% positive8% neutral32% negative

Across the one store that carries it, Thorne Amino Complex Travel Packs in Lemon has 49 ratings in total, and the themes below come from the five short written reviews that could be read on its page. Because only five written comments were readable, they say little in detail, and the picture they give is more positive than the star ratings. What buyers praise: the written reviews are mostly positive. Reviewers call the product very good, say it tastes great, and say it seems healthy. One reviewer says they feel amazing since starting Amino Complex. Another says the Thorne quality is always superb. Two other reviewers simply write "Great" or "Excellent" with nothing more specific. Travel and form: one reviewer specifically praises the packaging as convenient for travel, which fits the single-serve travel pack format. Taste is mentioned favorably, with the lemon flavor described as great, but nobody goes into detail about the flavor. What buyers complain about: no written review raises a complaint. Nothing in the readable text mentions mixing, aftertaste, or side effects, so there is no written evidence either way on those points. The star histogram is more critical than the written text, though. Of the ratings, 28 are five star, 1 is four star, 4 are three star, 6 are two star and 10 are one star. That means a sizeable minority of buyers, 16 giving one or two stars, were not satisfied, and none of their reasons appear in the written reviews on the page. Anyone weighing the product should treat the praise for taste and convenience as real but should also know that the low ratings are unexplained. Who it seems to suit: based on what reviewers say, it appeals to existing Thorne customers who trust the brand's quality, people who want an amino acid supplement they can carry while traveling, and people who care about taste and want something that feels healthy to take. One reviewer reports a noticeable boost in how they feel, but this is a single personal account and not a pattern across reviews. Value: no reviewer comments on price or value for money, so nothing can be said about that from the written feedback. Other forms: the summary covered only the powder travel packs, and no reviews of other forms such as gummies or capsules were included, so none are discussed here. Overall, the readable written feedback is brief and upbeat, centered on taste, travel convenience, and brand trust. The star distribution suggests a more mixed experience, with a clear group of dissatisfied buyers whose concerns are not spelled out.

Biohacker Summary

Members Only10 of 10 recommend it
10 of 10 biohackers on our panel recommend it

Seven of the ten panelists spoke about leucine, the main ingredient, and most of them recommend it, mainly because it switches on muscle building. Doses came up a few times: 2 to 3 grams per meal for those under 40 and 3 to 4 grams for those over 40, about 1 gram in a capsule with a meal for plant-based eaters, and 2 to 3 grams a day for muscle health with 8 or 9 grams as a possible best level. Several noted that enough high-quality animal protein already supplies leucine, and a few paired it with other essential amino acids or whey. Cautions came from three of them: one said leucine may be pro-aging, one said high levels could raise disease risk, and one said supplementing adds no benefit when protein intake is already good, and that it tastes bad. Tryptophan, methionine, lysine and threonine are smaller ingredients in this product, and the panel's comments on them were mostly about food sources, sleep, mood, and keeping methionine low.

See all 9 biohackers →Hide the biohackers
  • Ben Greenfield · Leucine · recommends
    • 29 Oct 2026 · recommends · YouTube ↗
      Describes leucine as the 'ignition' that turns on the signal for muscle protein synthesis, and that a sufficient dose is needed to hit the dose response and then have other essential amino acids to maintain the signal.
    • 9 Jul 2026 · recommends · YouTube ↗
      States that leucine is the primary trigger for muscle protein synthesis and recommends an essential amino acid blend with about 40% leucine for maximum stimulation.
    • 15 Apr 2026 · recommends · X ↗
      Recommends pulsing with compounds like leucine for maintaining and building muscle and maximizing muscle protein synthesis.
    • 10 Mar 2026 · Methionine · neutral · X ↗
      A new study found that lowering methionine in the diet of mice significantly increased calorie burning and weight loss, matching the metabolic effects of cold exposure.
    • 29 Jan 2026 · Methionine · neutral · YouTube ↗
      States that methionine is needed for glutathione production, and glutathione needs triple as we age.
    • 29 Jan 2026 · Threonine · neutral · YouTube ↗
      Mentions threonine as an amino acid essential for gut health.
    • 17 Jan 2026 · Tryptophan · neutral · YouTube ↗
      Mentions tryptophan as a co-factor and raw material needed to make melatonin.
    • 11 Oct 2025 · Tryptophan · neutral · YouTube ↗
      Mentions that simple amino acids like tryptophan and phenylalanine are methylated into neurotransmitters.
    • 11 Oct 2025 · Phenylalanine · neutral · YouTube ↗
      Mentions that simple amino acids like tryptophan and phenylalanine are methylated into neurotransmitters.
    • 19 Jul 2025 · Tryptophan · recommends · YouTube ↗
      Recommends ensuring enough tryptophan in the diet to naturally support the body's melatonin production, as it is a precursor to serotonin and then melatonin.
    • 12 Jun 2025 · Tryptophan · neutral · YouTube ↗
      Mentions tryptophan as a supplement that aids in serotonin production, as suggested by a guest.
    • 20 Feb 2025 · recommends · YouTube ↗
      Recommends Dileucine as a next-generation supplement for muscle recovery and protein synthesis, stating it delivers 86% more leucine to muscles and triggers 60% more protein synthesis than regular leucine, especially when paired with exercise.
    • 28 Dec 2024 · uses · YouTube ↗
      Dave Pascoe mixes up a concoction of different protein powders, leucine, and L-citrulline as a pre-workout drink.
    • 12 Dec 2024 · neutral · Podcast ↗
      Discusses the role of leucine in boosting muscle protein synthesis on plant-based diets.
  • Dr. Eric Berg · Leucine · recommends
    • 22 Oct 2026 · recommends · Podcast ↗
      The amino acid leucine is important for muscle growth, but getting sufficient protein is just as essential for maintaining muscle mass.
    • 23 Oct 2026 · L-Lysine · recommends · YouTube ↗
      Recommends L-lysine because it competes with L-arginine, which the virus needs to reproduce, thus blocking the virus from getting arginine and starving it off.
    • 18 Oct 2026 · neutral · YouTube ↗
      Mentions that animal protein provides leucine, an amino acid beneficial for muscle building.
    • 23 Sep 2026 · recommends · Podcast ↗
      Recommends getting enough leucine, a key amino acid for muscle growth, to help prevent and correct muscle loss.
    • 3 Aug 2026 · Tryptophan · recommends · Facebook ↗
      Mentions that certain foods contain tryptophan, which is in many different proteins, walnuts, milk, wine, and coffee, but warns that wine and coffee may still keep one awake.
    • 22 Jul 2026 · neutral · Podcast ↗
      Explains that leucine is an essential amino acid that signals muscles to grow, and its requirements increase with age, making it important for maintaining muscle after menopause.
    • 23 Oct 2025 · neutral · YouTube ↗
      Mentions that eggs contain all essential amino acids, including leucine, which is a key amino acid for building muscle.
    • 2 Oct 2025 · neutral · YouTube ↗
      Notes that the amino acid leucine, found in animal protein, stimulates insulin.
    • 11 May 2025 · Tryptophan · neutral · YouTube ↗
      Mentions that the FDA banned tryptophan for a period after serious side effects were linked to a bad batch, and the ban was lifted after a med's patents expired.
    • 22 Mar 2025 · Methionine · neutral · YouTube ↗
      Identifies methionine as one of the two amino acids from which the majority of dietary sulfur is obtained.
    • 21 Oct 2024 · neutral · Podcast ↗
      Notes that red meat contains leucine, an amino acid that triggers the synthesis of muscle.
    • 14 Mar 2024 · Tryptophan · neutral · Podcast ↗
      Notes that Tryptophan can turn into vitamin B3, but the mechanism is not very efficient.
    • 12 Mar 2024 · Tryptophan · neutral · YouTube ↗
      Notes that tryptophan can convert to B3, but the conversion efficiency is very low, requiring 60 times the units of tryptophan for one unit of B3.
    • 22 Feb 2024 · Histidine · recommends · Podcast ↗
      Recommends the right amount of histidine in one's diet to promote healthy hair growth by helping to produce keratin and regulating copper and zinc levels.
  • Thomas DeLauer · Leucine · recommends
    • 19 Oct 2026 · recommends · YouTube ↗
      Identifies leucine as the primary trigger for the mtorc1 pathway, which is the master switch for muscle protein synthesis, and recommends 2 to 3 grams per meal for those under 40, and 3 to 4 grams for those over 40.
    • 25 Sep 2026 · neutral · Facebook ↗
      Explains that leucine is important for muscle, with beef, whey, milk, and sardines clearing the 2-3g leucine threshold per meal, and that the threshold increases with age.
    • 21 Sep 2026 · neutral · Facebook ↗
      States that leucine is what flips the switch for muscle protein synthesis, and that adding leucine and essential amino acids to a small dose of whey can match the effect of a full 25-gram dose of protein.
    • 9 Aug 2026 · Tryptophan · neutral · YouTube ↗
      Believes that having enough tryptophan get into the brain over the course of the day enables the capacity to produce melatonin at night.
    • 1 Jul 2026 · Tryptophan · recommends · YouTube ↗
      Recommends tryptophan before bed for sleep.
    • 6 Jun 2026 · neutral · YouTube ↗
      Notes that leucine, an important amino acid for muscle growth, activates mTOR signaling after exercise, triggering the first step in building new muscle, and that leucine plus carbs together have the strongest signaling effect.
    • 16 May 2026 · Tryptophan · neutral · YouTube ↗
      Discusses tryptophan being taken off the market in the early 90s due to a bad batch from one company that had neurotoxins, leading to a quality control issue and a temporary ban.
    • 28 Apr 2026 · Tryptophan · uses · YouTube ↗
      Takes 500 to 1,000 mg of tryptophan at night to help produce serotonin and melatonin, which are important for tilting towards a parasympathetic tone and relaxation.
    • 20 Mar 2026 · Tryptophan · uses · YouTube ↗
      Mentions taking a tryptophan supplement before sleep.
    • 24 Feb 2026 · recommends · YouTube ↗
      Recommends taking 3 to 5 grams of leucine with meals, especially for older individuals who may struggle to meet minimum protein requirements, as it can help preserve muscle and increase muscle protein synthesis.
    • 23 Dec 2025 · recommends · YouTube ↗
      Recommends protein sources that are high in leucine as a '401k of your fat burner' because they lead to more metabolically active lean tissue, especially for people dropping weight.
    • 18 Dec 2025 · Tryptophan · stopped · YouTube ↗
      Rates tryptophan as "foggy" for sleep, explaining that while it's a precursor to serotonin and melatonin, it needs to be taken by itself without other food to avoid competing with other amino acids for absorption. He states he oftentimes takes it, but lately has not been.
    • 26 Nov 2025 · recommends · YouTube ↗
      Explains that leucine skyrockets mTor and phosphorylates P7S6K, which is exactly what one wants to be activating, especially post-workout but throughout the day if trying to build muscle and recover.
    • 30 Aug 2025 · Isoleucine · neutral · YouTube ↗
      Mentions that some people believe avoiding isoleucine is key to the sugar diet, potentially increasing FGF-21.
  • Dr. Rhonda Patrick · Leucine · recommends
    • 30 Sep 2026 · recommends · YouTube ↗
      Notes that foods high in leucine are going to really support muscle protein synthesis.
    • 5 Dec 2024 · recommends · YouTube ↗
      Explains that Leucine is the critical signal driving robust activation of mTOR, which plays key roles in skeletal muscle growth by driving muscle protein synthesis and recovery, but also notes a study suggesting Leucine might activate mTOR in the vascular system, promoting plaque buildup.
    • 30 Jul 2024 · neutral · YouTube ↗
      Highlights that leucine is an amino acid with strong signaling properties, stimulating the mTOR pathway and setting off the anabolic cascade for muscle protein synthesis.
    • 3 Jul 2023 · neutral · YouTube ↗
      Mentions that leucine, a branched-chain amino acid, and other essential amino acids may be partially protective against declines in muscle mass, but not entirely effective against strength declines.
    • 6 Dec 2022 · neutral · YouTube ↗
      Discusses leucine as an amino acid that kick-starts the muscle-growth process, noting that 2 to 3 grams may be important for older individuals to kick-start that process, but does not recommend it as a supplement if consuming high-quality animal-based protein sources.
    • 29 Jun 2022 · warns · YouTube ↗
      Warns that leucine is extraordinarily bitter and requires food science to mask its taste. He also states that leucine supplementation should be a last resort, advocating for a food-first approach.
    • 28 Jan 2020 · Tryptophan · neutral · YouTube ↗
      Mentions that NAD can be synthesized in the body from dietary sources including the amino acid tryptophan, found in foods like salmon, spinach, and nuts.
    • 5 Aug 2019 · Tryptophan · neutral · YouTube ↗
      Dr. Patrick explains that tryptophan is a precursor for serotonin, a neurotransmitter important for mood and cognition, and exercise increases its availability to be transported into the brain to form serotonin.
    • Date not recorded · neutral · Website ↗
      Identifies leucine as a major activator of mTORC1, which is critical for muscle protein synthesis.
    • Date not recorded · neutral · Website ↗
      Notes that leucine is the highest affinity amino acid sensor for mTORC1, explaining why branched-chain amino acids, particularly leucine, are used to enhance muscle growth or prevent degradation during exercise. He believes 5 grams during a workout is probably not harmful.
    • Date not recorded · Tryptophan · neutral · Website ↗
      Notes that tryptophan gets transported into the brain to be converted into serotonin but competes with BCAAs for transport, which are preferentially transported.
    • Date not recorded · Tryptophan · neutral · Website ↗
      Explains that genes converting tryptophan to serotonin in the gut and brain contain a vitamin D response element that represses gut serotonin production and increases brain serotonin.
    • Date not recorded · Methionine · neutral · Website ↗
      Methionine, along with other amino acids, regulates IGF-1 levels.
    • Date not recorded · Methionine · neutral · Website ↗
      Notes that in aged mice, methionine had a Goldilocks range within a low-amino-acid diet, where too little increased frailty and a moderate amount preserved lean mass and improved metabolism.
  • Dr. Mark Hyman · Leucine · recommends
    • 10 Aug 2026 · recommends · YouTube ↗
      Dr. Mark Hyman, agreeing with the guest, highlights leucine as a primary amino acid important for muscle protein synthesis.
    • 14 Jan 2026 · neutral · YouTube ↗
      States that leucine is important for muscle health and is the rate-limiting amino acid for turning on the switch that starts muscle building.
    • 14 Jan 2026 · Methionine · neutral · YouTube ↗
      Notes that as people age, glutathione production goes down, and they might need three times more protein in methionine.
    • 27 Aug 2025 · Methionine · warns · YouTube ↗
      Notes concerns in the longevity camp about excessive methionine intake, especially if not balanced with glycine, which could theoretically impair longevity.
    • 25 Jun 2025 · recommends · YouTube ↗
      Recommends leucine, an amino acid, for making muscle.
    • 26 Feb 2025 · Tryptophan · recommends · YouTube ↗
      Recommends tryptophan as an essential neuro-nutrient and a precursor for serotonin, which repairs the hippocampus, noting that it can be ordered from Amazon.
    • 2 Oct 2024 · Tryptophan · warns · YouTube ↗
      States that restricting tryptophan is not the solution for long COVID, as low tryptophan is an effect of the condition, and simply adding more does not help, especially if it's being metabolized into poisonous quinolinic acid.
    • 13 Sep 2024 · Tryptophan · neutral · YouTube ↗
      Notes that tryptophan, a precursor to serotonin, can improve constipation in IBS-C by increasing intestinal transit time and motility, but high levels could worsen IBS-D.
    • 11 Sep 2024 · neutral · YouTube ↗
      Highlights leucine as an essential amino acid that is nearly highest in protein sources and acts as a unique amino acid for metabolic signaling, like a switch that turns on muscle building.
    • 11 Sep 2024 · Tryptophan · neutral · YouTube ↗
      States that tryptophan is necessary for serotonin production in the brain.
    • 11 Sep 2024 · Threonine · neutral · YouTube ↗
      Mentions threonine as an essential amino acid for mucin production in the gut.
    • 21 Aug 2024 · L-Lysine · recommends · YouTube ↗
      Recommends pairing high-dose IV vitamin C with L-lysine, an amino acid with an antiviral component, for viral reactivation.
    • 14 Aug 2024 · Tryptophan · neutral · YouTube ↗
      Mentions looking at tryptophan as an amino acid supplement.
    • 29 May 2024 · Phenylalanine · recommends · YouTube ↗
      Sometimes increases the dose of phenylalanine in conjunction with essential amino acids for depression.
  • Andrew Huberman · Leucine · recommends
    • 25 Jun 2026 · recommends · YouTube ↗
      Suggests that adding free leucine, perhaps one gram in a capsule with a normal meal, can significantly boost protein synthetic response, especially for plant-based individuals.
    • 6 Aug 2026 · Tryptophan · recommends · Podcast ↗
      Recommends tryptophan-rich foods to improve serotonin and mood.
    • 6 Aug 2026 · Tryptophan · recommends · YouTube ↗
      Notes that tryptophan is an amino acid precursor to serotonin synthesis and that many foods enriched in tryptophan can lead to net increases in serotonin, impacting feelings of well-being.
    • 30 Oct 2025 · warns · YouTube ↗
      Suggests that leucine, because it triggers cellular growth by activating the mTOR pathway, is actually pro-aging, similar to growth hormone and testosterone, offering immediate benefits at the expense of long-term health.
    • 23 Jun 2025 · Tryptophan · recommends · Podcast ↗
      Recommends tryptophan to improve mood and gut health, and for irritable bowel syndrome.
    • 23 Jun 2025 · Tryptophan · recommends · YouTube ↗
      Recommends ensuring sufficient levels of tryptophan in dietary intake, noting that turkey and dairy products are good sources, as it is a precursor to serotonin.
    • 25 Apr 2025 · neutral · YouTube ↗
      Andrew Huberman explains that leucine is an essential amino acid important for inducing muscle protein synthesis, and it is found in high levels in sources like whey protein, beef, chicken, and eggs.
    • 10 Apr 2025 · neutral · Podcast ↗
      Discusses leucine.
    • 12 Dec 2024 · Tryptophan · warns · YouTube ↗
      Tryptophan or anything that contains 5-HTP (serotonin or a precursor to serotonin) could disrupt the timing of REM sleep and slow wave sleep.
    • 7 Oct 2024 · Methionine · recommends · YouTube ↗
      Recommends methionine as a good methyl donor to help lower homocysteine levels and reduce cardiovascular risk.
    • 24 Jun 2024 · recommends · YouTube ↗
      States that leucine is uniquely stimulating to skeletal muscle and recommends consuming closer to 9 grams of leucine per day, which is two to three times the RDA, for optimal muscle health.
    • 18 Dec 2023 · warns · YouTube ↗
      Notes that leucine, isoleucine, and valine, which are branch chain amino acids, make insulin go up.
    • 18 Dec 2023 · Isoleucine · warns · YouTube ↗
      Notes that leucine, isoleucine, and valine, which are branch chain amino acids, make insulin go up.
    • 18 Dec 2023 · Valine · warns · YouTube ↗
      Notes that leucine, isoleucine, and valine, which are branch chain amino acids, make insulin go up.
  • Dave Asprey · Leucine · warns
    • 3 Feb 2026 · warns · YouTube ↗
      States that very low levels of leucine are probably promoting high levels of protection against aging and diseases, but also promoting frailty, and high levels of this amino acid could be a risk for developing a number of diseases.
    • 25 Jul 2026 · Tryptophan · recommends · YouTube ↗
      Recommends tryptophan, an amino acid from high-quality complete animal protein sources like turkey, as a raw material for NAD+ production.
    • 9 Jul 2026 · Tryptophan · neutral · YouTube ↗
      Recalls when tryptophan was taken out of health food stores due to a contaminated baby formula study, not because of tryptophan itself.
    • 30 May 2026 · Tryptophan · recommends · YouTube ↗
      Dave Asprey recommends tryptophan, an amino acid, as one of the two most important raw materials for NAD+ production, found in high-quality complete protein sources.
    • 16 Oct 2025 · Tryptophan · recommends · YouTube ↗
      Explains that modern farming practices have reduced tryptophan content in plants, and we need tryptophan to turn into serotonin to repair the hippocampus, melatonin, and DMT.
    • 5 Aug 2025 · Phenylalanine · neutral · YouTube ↗
      Mentions phenylalanine as a precursor and building block for dopamine, and that the brain synthesizes dopamine from precursors like phenylalanine.
    • 15 Apr 2025 · Tryptophan · neutral · YouTube ↗
      Mentions tryptophan as a compound that might be needed if there's a blockage in neurotransmitter pathways.
    • 6 Feb 2025 · Methionine · neutral · YouTube ↗
      States that if you are deficient in methionine, your gut motility is messed up, leading to consequences like irritable bowel syndrome.
    • 14 Jun 2024 · Tryptophan · warns · YouTube ↗
      States that excessive tryptophan is not good for you.
    • 23 May 2023 · recommends · YouTube ↗
      Recommends ensuring enough Leucine, specifically two and a half grams, to activate muscle protein synthesis, otherwise consumed protein may not be effective.
    • 25 Apr 2023 · neutral · YouTube ↗
      States that 2.5 grams of leucine are needed in a meal to activate mTOR and stimulate muscle synthesis.
    • 18 Apr 2023 · Methionine · recommends · YouTube ↗
      Recommends looking at methionine for chronic allergies, noting it is an amino acid often restricted on plant-based diets.
    • 2 Dec 2022 · Tryptophan · neutral · YouTube ↗
      Discusses tryptophan, an amino acid, and its theoretical role in raising mTOR and increasing cancer risk.
    • 2 Dec 2022 · Methionine · neutral · YouTube ↗
      Discusses methionine, an amino acid more common in animal protein, and its theoretical role in raising mTOR and increasing cancer risk.
  • Peter Attia · Leucine · recommends
    • 26 Sep 2025 · recommends · YouTube ↗
      States that leucine is critical for muscle protein synthesis and recommends around 8 or 9 grams a day for optimal muscle health.
    • 26 Sep 2025 · Threonine · neutral · YouTube ↗
      Mentions that threonine is important for mucin production in the gut.
    • 21 Sep 2025 · recommends · YouTube ↗
      Recommends two to three grams of leucine a day for muscle health, with optimal health probably around eight or nine grams.
    • 30 Aug 2024 · neutral · YouTube ↗
      Recounts a story where a vegan doctor chastised him for suggesting ingesting five grams of leucine during a workout due to its negative effect on mTOR and potential link to cancer, which Peter Attia found amusing.
    • 25 May 2024 · warns · YouTube ↗
      Warns that there is no benefit to supplementing leucine specifically if one is already consuming enough high-quality protein, and notes that leucine tastes horrible.
    • 27 Apr 2024 · Methionine · neutral · YouTube ↗
      Notes that many plant-derived proteins are low in methionine, and some meat alternatives are fortified with it.
    • 24 Apr 2024 · neutral · YouTube ↗
      Mentions that estimations suggest two to three grams of Leucine in a meal will induce a rapid increase in circulating Leucine, stimulating muscle protein synthesis.
    • 22 Apr 2024 · recommends · YouTube ↗
      Highlights that leucine content is an important factor in the anabolic response, and adding free leucine to casein can increase its anabolic effect.
    • 22 Apr 2024 · Methionine · recommends · YouTube ↗
      Recommends focusing on getting enough methionine, especially for plant-based patients, to ensure adequate amino acid intake for muscle protein synthesis.
    • 18 Apr 2024 · recommends · YouTube ↗
      Recommends tracking amino acids and ensuring 2 to 4 grams per serving of leucine for muscle mass.
    • 18 Apr 2024 · Methionine · recommends · YouTube ↗
      Recommends tracking amino acids and ensuring at least 1 gram of methionine per day for muscle mass.
    • 14 Mar 2024 · neutral · YouTube ↗
      Discusses experiments on Leucine and its effect on muscle protein turnover and fat metabolism.
    • 9 Mar 2024 · neutral · YouTube ↗
      Mentions Leucine as one of the four signals that regulate mTOR, which is involved in protein synthesis.
    • 25 Sep 2023 · neutral · YouTube ↗
      Explains that leucine binds to a protein called sestrin, which acts as its receptor, and the crystal structure shows how leucine is nestled in a small pocket, making it difficult to mimic its anabolic effects with other molecules.
  • Siim Land · Isoleucine · neutral
    • 18 Aug 2024 · neutral · YouTube ↗
      Notes that his isoleucine levels went down because he is taking leucine, which is a branch chain amino acid.
    • 19 Oct 2026 · Methionine · recommends · YouTube ↗
      Recommends keeping methionine intake slightly lower to support autophagy.
    • 13 Oct 2026 · Methionine · uses · Instagram ↗
      Lowered his methionine intake as part of an amino acid strategy.
    • 21 Aug 2026 · Methionine · warns · Instagram ↗
      States that methionine in excess may accelerate aging.
    • 30 Jul 2026 · Methionine · uses · Instagram ↗
      Lowered his methionine intake to reduce visceral fat.
    • 28 Jul 2026 · Methionine · uses · X ↗
      Reduced visceral fat by reducing methionine.
    • 27 Jun 2026 · Methionine · neutral · Podcast ↗
      Discusses the methionine and glycine ratio from animal protein.
    • 29 Apr 2026 · Methionine · warns · YouTube ↗
      Explains that too much methionine accelerates aging and shortens lifespan, and also appears to promote visceral fat gain.
    • 4 Feb 2026 · Methionine · recommends · YouTube ↗
      To get to the 10th percentile of visceral fat and lower, Siim Land recommends reducing methionine intake.
    • 10 Sep 2025 · Methionine · warns · YouTube ↗
      Warns that methionine, an amino acid high in animal protein, has been seen to shorten lifespan in animals, and most people eat too much methionine without enough glycine.
    • 29 Aug 2025 · Methionine · warns · YouTube ↗
      Notes that in animal studies, methionine excess is associated with shorter lifespan and high methionine intake drives aging or shortens maximum lifespan.
    • 29 Nov 2024 · Phenylalanine · neutral · YouTube ↗
      Notes that L-phenylalanine can boost dopamine, with many articles available on PubMed.
    • 18 Aug 2024 · Leucine · uses · YouTube ↗
      Despite high protein and whey intake, Siim Land's leucine levels remain low, hovering around 70, which he attributes to increased muscle mass and the body fighting infection.
    • 18 Aug 2024 · Phenylalanine · neutral · YouTube ↗
      Noticed that his phenylalanine levels go up if he generally eats more protein, as it is not heavily utilized by exercise.

RAL Summary

Members OnlyTier 4 for Muscle and Strength

Studies are mixed: leucine helps mainly when paired with protein, and the branched-chain amino acid mixes give inconsistent results. Only 61% of reviews are positive, below the two thirds needed for a higher tier.

  • Emerging: not enough evidence to rank higher yet.

Where the evidence disagrees: 32 of the 113 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Musculoskeletal system

Combine with: For muscle building and recovery, pair it with a high-quality whey or plant protein to supply the full range of essential amino acids, and creatine monohydrate (3-5 g daily) for strength and lean mass. Vitamin D3 with K2 and magnesium support muscle function, recovery, and hormonal health. Omega-3 fish oil helps reduce exercise-related inflammation. If the broader goal is male weight management, add green tea extract (EGCG), fiber such as glucomannan or psyllium for satiety, and berberine or chromium for blood sugar support, alongside a calorie-controlled diet and resistance training. Consult a healthcare provider before combining supplements, especially with medical conditions or medications.

Possible side effects: No major side effects reported.

Supplement Facts

L-Leucine 1.25 g · L-Lysine 650 mg · L-Isoleucine 625 mg
Supplement Facts
Serving Size One Stick Pack (7.8 g)
Servings Per Container 30
Amount Per Serving% Daily Value
Calories25
Total Carbohydrate1 g
L-Leucine1.25 g†
L-Lysine650 mg†
L-Isoleucine625 mg†
L-Valine625 mg†
L-Threonine350 mg†
L-Histidine150 mg†
L-Cystine150 mg†
L-Phenylalanine100 mg†
L-Methionine50 mg†
L-Tyrosine30 mg†
L-Tryptophan20 mg†
† Daily Value not established.

Other ingredients: Flavor, Citric Acid, Rebaudioside A (from stevia), Turmeric Powder.

Directions: Mix 1 stick pack with at least 8 ounces of water one to two times daily or as recommended by your health-care practitioner.

Label source: Reverseagelab · Report a label change

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Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.