Thorne Basic Nutrients 2/Day - NSF Certified for Sport Review

Basic Nutrients 2/Day is a comprehensive daily supplement from Thorne, formulated for people who want foundational multivitamin and mineral support in fewer capsules. The product is a complete multi-vitamin and mineral formula taken as two capsules per day, which the page presents as a convenient 2-capsule-a-day protocol. The listed serving size is 2 capsules and the container holds 30 servings. The default option on the page is a 60 capsule bottle priced at $40, or $36 with a subscription that saves 10 percent. The page states that the product contains key nutrients for heart, brain, nerve, immune, bone, and skin health. Thorne says it uses the purest and most absorbable forms of vitamins and minerals available, without unnecessary additives and preservatives. Key ingredients named on the page include biotin, boron glycinate, chromium nicotinate glycinate, copper bisglycinate, gamma tocopherol, folate as L-5-MTHF, iodine, lutein from aztec marigold, magnesium bisglycinate, manganese, vitamin A from beta carotene and palmitate, thiamin, vitamin B12 as methylcobalamin, pantothenic acid, niacinamide, pyridoxal 5-phosphate, riboflavin 5-phosphate, vitamin C, vitamin E as d-alpha-tocopheryl acid succinate, zinc bisglycinate, calcium, selenium glycinate, vitamin D3, and vitamin K2 as MK-4 along with vitamin K1. The page lists benefits including eye health from vitamin A, antioxidant support from vitamins C and E and mixed tocopherols, bone and immune support from vitamin D, nerve and blood vessel support from B vitamins, bone and blood vessel health from vitamins K1 and K2, immune and skin support from zinc bisglycinate, and support for healthy blood sugar levels from chromium. The page also explains that few people get all the nutrition they need from diet, citing an analysis of NHANES data that estimates nearly one-third of the U.S. population is at risk of one or more micronutrient deficiencies. It notes that a survey published in JAMA Internal Medicine found 32 percent of U.S. adults take a multivitamin or mineral, and that groups with particular risk include teenagers, athletes, the elderly, people on restrictive diets, people with chronic disease, and people taking certain medications. Thorne describes its product as NSF Certified for Sport, meaning every batch is tested for compliance with label claims and for the absence of nearly 300 substances banned by many major athletic organizations. The warnings section states the product is contraindicated for anyone with a history of hypersensitivity to its ingredients, that iodine may occasionally cause an allergic reaction, that pregnant people should consult a health-care practitioner, that vitamin K can interfere with a med drugs such as a med, and that 5-methyltetrahydrofolate is not recommended alongside a med cancer therapy.

Product Focus: EnergyAlso covers:BrainMuscles and jointsImmune systemMetabolism
Tier ⓘ
Tier 2 · Rank 10
Tier 2 · Researched. Human studies show improvement in an aging-related function or a specific goal, and the reviews agree. Rank 10 within Tier 2 for Energy; 10 of 82 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
82 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
82% of 15,422
Biohacker Mentions
9 of 10
Cost per month
$40

Study, Trial or Testing Result Summary

Members Only165 human studies · 75 improved

10 of these 165 human studies gave the ingredient by drip or injection, not by mouth.

165 human studies75 improved68 no effect88,710 people studied

The main support for energy comes from vitamin D, which this product gives at a full studied dose. In 46 active men, the same daily amount for 12 weeks lowered fatigue and improved fitness [1]. In 120 tired people low in vitamin D, one large dose cut fatigue, with 72% improving versus 50% on placebo [2]. Deficient women had slightly better vitality after a year [3]. However, 34,157 older women on a lower dose saw no change in energy [4]. Vitamin C at this dose improved well-being and fatigue only in young adults who were low in it [5], and a large trial in people who were not low found no benefit [6]. Thiamin helped older women with a mild shortage [7], but a nutrient mix with thiamin, riboflavin, niacin and vitamin B6 did not ease fatigue in dialysis patients [8]. Vitamin B6 helped tiredness in women with premenstrual symptoms [9], but larger trials found no gain [10]. Vitamin B3 forms did not improve tiredness in a large review [11]. Vitamin A here is far below the dose that reduced fatigue in trials [12], and vitamin E is only a trace amount compared with studied doses [13]. Vitamin K has no supplement trial for energy [14]. Animal and cell studies are never counted.

See all 165 studies →Hide the studies

Review Totals and Summary

Members Only15,422 reviews · 82% positive
15,422 reviews · Amazon 7,927 · Store.mayoclinic 6,203 · Thorne 1,292
82% positive6% neutral12% negative

Buyers are mostly positive about Thorne Basic Nutrients 2/Day capsules, though the written feedback is thin and a few people felt no change. The product carries about 9,219 ratings across the stores, and the one average given, 4.3, comes from the Thorne.com page. **What buyers say it did for them:** Most happy buyers describe a general lift rather than a measured result. One reports "more energy and general feeling of well-being." Another says, "Since I started my regiment.. I feel 💯." A 64-year-old reviewer credits Thorne products with keeping her in "good health." The most specific benefit is in nails, which one buyer says went "from brittle and splitting to thick, strong and shiny." **What they complain about:** The main complaint is that some people notice nothing. One reviewer wrote, "not sure. Feel no differant." The store pages' own summaries also say some customers are dissatisfied with the smell and taste. Those complaints come from the pages' overviews and not from the reviews shown. The one- and two-star ratings suggest a minority of buyers were unhappy, but their reasons are not visible here. **Taste, smell, pill size or form:** The store summaries say some customers dislike the smell and taste. The written reviews give no detail about pill size or how the capsules go down, so there is nothing more to report on those points. Reviews of other forms of the product, if any appeared on these pages, were left out; this summary covers the capsules only. **Value for money:** Nobody in the reviews or store summaries comments on price or value. The summaries mention only that customers praise the product's quality and ease of use. **Tolerability:** One buyer says, "No problems with side effects," which is reassuring for anyone starting a daily multivitamin. This is a single comment, so treat it as one person's experience. **Who it seems to suit and who it did not:** The product seems to suit people who want a daily multivitamin from a brand they trust and who are content with a general sense of wellness. Longtime Thorne users in particular speak well of it. One reviewer put it simply: "Start your day with Thorne Multivitamin!" It did less for people hoping for a clear, noticeable change, since at least one buyer felt no difference. The reviewers who were happy often described their results in general terms, so it is hard to say how it would work for a specific health goal. Anyone sensitive to smell or taste may want to keep the reported complaints in mind. **Overall:** The written feedback is favorable but limited to a handful of short comments, so the 4.3 average from a much larger group of ratings tells you more than the text does. Expect a well-regarded daily multivitamin. Energy, well-being and nail improvements are the benefits people mention, and some buyers notice nothing at all.

Biohacker Summary

Members Only9 of 10 recommend it
9 of 10 biohackers on our panel recommend it

This product is a multivitamin, and the panel has no statements about the product as a whole, only about its individual vitamins, all of which are smaller ingredients in this product. Vitamin D drew the most attention, with all ten panelists speaking about it, and most of the panel recommend or use it for immune, brain, mood, muscle and bone health. Doses ranged from 5,000 IU of D3 taken in the morning by two of them to 10,000 IU daily in winter from one, while one said most people only need it if they are deficient, and several advise testing blood levels and taking it with dietary fat. Vitamin C was recommended by about half the panel, often paired with collagen for joints and skin, and vitamin K2 was taken in the morning at 90 to 100 mcg by two panelists. Vitamins A and E got only neutral mentions, and no one said they stopped taking anything.

See all 10 biohackers →Hide the biohackers
  • Dr. Eric Berg · Vitamin D · warns
    • 2 Nov 2026 · warns · Facebook ↗
      Dr. Berg warns that the recommended daily intake for vitamin D is based on a massive error and that the actual necessary amount is closer to 8,895 IU, with millions remaining deficient.
    • 31 Oct 2026 · recommends · YouTube ↗
      Recommends getting vitamin D levels tested to ensure they are between 50 and 70, as vitamin D is intimately involved in regulating prostate size.
    • 31 Oct 2026 · Vitamin K · recommends · Podcast ↗
      Discusses foods that contain Vitamin K2.
    • 30 Oct 2026 · recommends · YouTube ↗
      Recommends taking at least 10,000 IUs of vitamin D3 every single day in the winter, stating it is the most important vitamin to lower cancer risk.
    • 30 Oct 2026 · recommends · YouTube ↗
      Recommends vitamin D to support the immune system, aiming for blood levels between 80 to 100 ng per ml.
    • 26 Oct 2026 · Vitamin C · neutral · YouTube ↗
      Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
    • 25 Oct 2026 · recommends · YouTube ↗
      Recommends taking no less than 10,000 IU's of vitamin D3 for osteoporosis, alongside magnesium and K2.
    • 25 Oct 2026 · recommends · X ↗
      Recommends increasing vitamin D to restore balance and support healthy blood pressure.
    • 25 Oct 2026 · Vitamin K · recommends · YouTube ↗
      Recommends taking 40 to 45 milligrams of vitamin K2 daily for osteoporosis, citing a study from Japan with great results.
    • 25 Oct 2026 · Vitamin C · recommends · Facebook ↗
      Dr. Berg states that Vitamin C helps fight biofilms and is essential for making collagen in gums, teeth, and capillaries.
    • 24 Oct 2026 · neutral · YouTube ↗
      States that a lack of vitamin D can potentially cause achy bones or crashing mood.
    • 24 Oct 2026 · Vitamin K · neutral · YouTube ↗
      Mentions that easy bruising can result from a lack of vitamin K1.
    • 24 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends Vitamin C as a cofactor, especially for collagen.
    • 24 Oct 2026 · Vitamin A · neutral · YouTube ↗
      Notes that low vitamin A can lead to dry eyes, dry mouth, and night vision issues.
  • Dave Asprey · Vitamin D · uses
    • 1 Nov 2026 · uses · Facebook ↗
      Takes Vitamin DAKE from Suppgrade Labs.
    • 25 Oct 2026 · recommends · Podcast ↗
      Suggests that vitamin D supports brain health, muscle function, and focus.
    • 24 Oct 2026 · Vitamin C · recommends · Facebook ↗
      Recommends taking vitamin C for better skin health.
    • 9 Oct 2026 · recommends · Podcast ↗
      Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense for male fertility, even though supplementation did not improve overall semen parameters in a randomized trial.
    • 7 Oct 2026 · uses · YouTube ↗
      States that currently, he is only taking vitamin C and vitamin D.
    • 7 Oct 2026 · Vitamin C · uses · YouTube ↗
      States that currently, he is only taking vitamin C and vitamin D.
    • 7 Oct 2026 · Vitamin E · uses · YouTube ↗
      Dave Asprey's kids get a little bit of vitamin E every day, which helps to stabilize the bad oils they get when eating at restaurants.
    • 7 Oct 2026 · Vitamin K · recommends · YouTube ↗
      Recommends taking vitamin K2 with vitamin D to keep calcium in the bones, and suggests kids also take it for stronger bones.
    • 7 Oct 2026 · Vitamin K · recommends · YouTube ↗
      Recommends Vitamin K2, stating it supports healthy calcium metabolism.
    • 5 Sep 2026 · recommends · YouTube ↗
      Recommends vitamin D, noting it's actually a hormone and that most people are deficient, even those who take it, because they don't take enough.
    • 5 Sep 2026 · Vitamin K · recommends · YouTube ↗
      Recommends adding vitamin K2 to vitamin D supplementation.
    • 3 Sep 2026 · recommends · YouTube ↗
      States that most people on the spectrum are low in vitamin D and need more of it, mentioning his own product, Vitam DAKNE, which contains real vitamin A.
    • 3 Sep 2026 · Vitamin A · recommends · YouTube ↗
      Recommends real vitamin A for people on the spectrum, noting that many cannot convert plant vitamin A and need the good stuff he includes in his Vitam DAKNE product.
    • 29 Aug 2026 · recommends · YouTube ↗
      Dave Asprey recommends Vitamin D3 with K2, explaining D3 is a hormone made from sunlight and K2 directs calcium into bones, not arteries, highlighting its low cost, widespread deficiency, and the ability to test its effectiveness.
  • Siim Land · Vitamin D · recommends
    • 31 Oct 2026 · recommends · YouTube ↗
      Advises against taking vitamin D in the morning with other supplements because it is fat soluble and requires dietary fat for better absorption.
    • 29 Oct 2026 · recommends · Instagram ↗
      Recommends taking Vitamin D with fat for better absorption.
    • 29 Oct 2026 · Vitamin C · recommends · Instagram ↗
      Recommends taking vitamin C with collagen to support joint collagen synthesis.
    • 24 Oct 2026 · neutral · Instagram ↗
      States that Vitamin D connects biology to light and that UVB reaching the skin enables its production.
    • 14 Oct 2026 · Vitamin C · neutral · Instagram ↗
      States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
    • 9 Oct 2026 · Vitamin K · neutral · Instagram ↗
      Notes that Vitamin K2 helps activate proteins involved in bone mineralization and calcium regulation.
    • 8 Oct 2026 · Vitamin K · neutral · YouTube ↗
      Mentions that prunes contain vitamin K, which is a factor in their ability to help with bone density.
    • 7 Oct 2026 · Vitamin K · recommends · Instagram ↗
      Recommends Vitamin K2 for bone health and calcium metabolism, based primarily on human research, especially randomized controlled trials showing measurable benefits.
    • 6 Oct 2026 · Vitamin K · neutral · X ↗
      Lists Vitamin K2 as one of 15 supplements backed by human studies.
    • 30 Sep 2026 · Vitamin C · neutral · X ↗
      Lists sauerkraut and fruit as sources of Vitamin C.
    • 30 Sep 2026 · Vitamin K · neutral · X ↗
      Lists leafy greens as a source of Vitamin K1.
    • 30 Sep 2026 · Vitamin A · neutral · X ↗
      Lists liver and carrots as sources of Vitamin A.
    • 6 Sep 2026 · recommends · Instagram ↗
      Thinks vitamin D has some of the strongest evidence and is worth considering.
    • 6 Sep 2026 · neutral · X ↗
      Notes that Vitamin K2 pairs well with vitamin D by regulating calcium and bone mineralization.
  • Ben Greenfield · Vitamin E · neutral
    • 29 Oct 2026 · neutral · YouTube ↗
      Mentions a recent study showing no significant increase in bleeding for patients on Vitamin E supplementation during open heart surgery, which was interesting for him to learn.
    • 29 Oct 2026 · Vitamin C · recommends · YouTube ↗
      States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
    • 29 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Notes that Vitamin D is actually a hormone and recommends patients aim for levels around 40 to 50, or even 60 for fracture healing, for optimal healing, as opposed to just above 20 which is considered normal.
    • 21 Oct 2026 · Vitamin A · neutral · Instagram ↗
      Notes that Vitamin A is a fat-soluble vitamin that supports healthy skin cell turnover.
    • 15 Oct 2026 · Vitamin C · recommends · Podcast ↗
      Mentions vitamin C as part of a bare-minimum protocol.
    • 15 Oct 2026 · Vitamin D · recommends · Podcast ↗
      Mentions vitamin D as part of a bare-minimum protocol.
    • 15 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Advises getting vitamin D levels between 60 and 100 nanograms per milliliter as a minimum step for overall health and to slow down heart disease.
    • 15 Oct 2026 · Vitamin K · neutral · Facebook ↗
      Discusses vitamin K2, specifically the menaquinone forms, as crucial for arterial health and notes that it breaks down into MK-4 and MK-7.
    • 15 Oct 2026 · Vitamin K · uses · YouTube ↗
      Explains that gut bacteria liberate K from the diet or make the K needed, and that poor absorption of vitamin K due to bacterial imbalances is linked to heart disease.
    • 24 Sep 2026 · Vitamin C · neutral · YouTube ↗
      Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
    • 29 Aug 2026 · Niacin · neutral · YouTube ↗
      States that Nrf2 activators, when combined with something like niacin, may have a good effect on plaque progression.
    • 25 Aug 2026 · Vitamin C · neutral · X ↗
      Notes that IV vitamin C has been used for decades for cancer patients with almost no standardization and that he receives many questions about its effectiveness and combination with chemo.
    • 20 Aug 2026 · Vitamin D · uses · YouTube ↗
      Has been taking Vitamin D3 K2 for over a decade.
    • 8 Aug 2026 · Vitamin D · neutral · Instagram ↗
      Notes that sunlight influences more than just vitamin D production.
  • Dr. Mark Hyman · Vitamin D · recommends
    • 26 Oct 2026 · recommends · Facebook ↗
      Recommends Vitamin D for health, stating that amazing things happen when patients' vitamin D statuses reach optimal levels.
    • 21 Oct 2026 · neutral · YouTube ↗
      Mentions vitamin D as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
    • 19 Oct 2026 · neutral · YouTube ↗
      Notes that vitamin D plays a role in immune function.
    • 19 Oct 2026 · Vitamin A · neutral · YouTube ↗
      Mentions that vitamin A levels can be looked at to get a deep sense of what's happening with nutrient levels.
    • 12 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
    • 8 Oct 2026 · recommends · Instagram ↗
      Recommends checking vitamin D levels and states that if they had to pick one single intervention for immune health, vitamin D would be it.
    • 7 Oct 2026 · neutral · Podcast ↗
      Dr. Hyman discusses vitamin D in relation to sun exposure patterns.
    • 7 Oct 2026 · recommends · YouTube ↗
      States that vitamin D supplementation can help with oxidative stress.
    • 7 Oct 2026 · Vitamin C · neutral · Podcast ↗
      Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
    • 7 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Mentions topical vitamin C as an antioxidant that can help skin with aging.
    • 6 Oct 2026 · Vitamin C · neutral · X ↗
      Mentions that what they do when a cold comes on is not just vitamin C.
    • 5 Oct 2026 · neutral · Podcast ↗
      Mentions vitamin D as a key nutrient for supporting immune function.
    • 5 Oct 2026 · recommends · YouTube ↗
      States that vitamin D is probably the single most important intervention for immune health, recommending levels of 45 to 70 and emphasizing testing to determine the right dose.
    • 5 Oct 2026 · Vitamin A · recommends · YouTube ↗
      Recommends taking 50,000 units of vitamin A for three to five days right at the onset of symptoms if one feels they might be getting sick.
  • Thomas DeLauer · Vitamin C · recommends
    • 26 Oct 2026 · recommends · YouTube ↗
      Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
    • 23 Oct 2026 · uses · YouTube ↗
      Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
    • 23 Oct 2026 · Vitamin D · uses · YouTube ↗
      Uses vitamin D3 in the fall and winter months when getting less sun, as it's important to supplement it then.
    • 20 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends taking a massive amount of vitamin D simultaneously with an early morning massive breakfast to help reset circadian rhythms and address hyperphagia.
    • 8 Oct 2026 · Vitamin D · recommends · Facebook ↗
      Recommends Vitamin D, stating that it has receptors throughout the brain and deficiency can quickly impact brain and mood.
    • 6 Oct 2026 · Vitamin D · uses · YouTube ↗
      Takes supplemental vitamin D because he is skin sensitive and from northern latitudes, limiting his UV exposure.
    • 5 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends taking vitamin D on non-liver days to ensure both nutrients get proper receptor access.
    • 4 Oct 2026 · recommends · YouTube ↗
      Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
    • 29 Sep 2026 · uses · YouTube ↗
      Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
    • 29 Sep 2026 · Vitamin D · uses · YouTube ↗
      Takes Purity's liquid vitamin D3 with K2 because she is constantly inside during the day; D3 is for overall wellness and K2 helps the body absorb calcium properly.
    • 18 Sep 2026 · neutral · Facebook ↗
      Compares the Vitamin C content of oranges (53mg) to guava (228mg), noting guava has 4x more.
    • 11 Sep 2026 · Vitamin D · recommends · YouTube ↗
      Recommends getting vitamin D, suggesting it can be obtained while walking.
    • 6 Sep 2026 · Vitamin D · recommends · Instagram ↗
      States that vitamin D is best obtained from the sun, but getting it from food definitely helps, and notes its role as a hormone influencing many cells.
    • 5 Sep 2026 · Niacin · uses · YouTube ↗
      Uses niacin as part of their detoxification protocol, taking enough to flush about half an hour before a sauna session.
  • Bryan Johnson · Vitamin K · uses
    • 22 Oct 2026 · uses · X ↗
      Takes 90 mcg of Vitamin K2 in the morning for general health.
    • 22 Oct 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 15 Aug 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 3 Jul 2026 · Vitamin D · neutral · X ↗
      Mentions that the sunlight assessment claims low vitamin D levels cause the immune system to misfire, and notes that their vitamin D has been measured.
    • 4 May 2026 · uses · X ↗
      Takes 100 mcg of Vitamin K2 in the morning for longevity.
    • 4 May 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for longevity.
    • 2 May 2026 · uses · X ↗
      He takes 100 mcg of Vitamin K2 in the morning for general health.
    • 2 May 2026 · Vitamin D · uses · X ↗
      He takes 5000 IU of Vitamin D3 in the morning for general health.
    • 21 Apr 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 15 Apr 2026 · uses · X ↗
      Takes 100 mcg of Vitamin K2 in the morning for longevity.
    • 15 Apr 2026 · Vitamin D · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning for longevity.
    • 14 Apr 2026 · uses · X ↗
      Takes 90 mcg of Vitamin K2 in the morning.
    • 14 Apr 2026 · Vitamin D · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning.
    • 8 Apr 2026 · uses · X ↗
      Takes 100 mcg of Vitamin K2 in the morning.
  • Dr. Rhonda Patrick · Vitamin D · neutral
    • 5 Oct 2026 · neutral · Facebook ↗
      Vitamin D supplementation was linked to a 40% lower risk of dementia in an observational study of more than 12,000 older adults.
    • 30 Sep 2026 · recommends · YouTube ↗
      Mentions that vitamin D also plays a role in maintaining muscle mass.
    • 28 Sep 2026 · recommends · YouTube ↗
      Recommends ensuring adequate vitamin D intake for men's sperm health.
    • 24 Sep 2026 · neutral · Facebook ↗
      Vitamin D and strength training alone did not, but adding them strengthened the effect on one clock, with the full combination slowing that measure by ~3.8 months.
    • 25 Aug 2026 · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 25 Aug 2026 · Vitamin K · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 25 Aug 2026 · Vitamin E · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 25 Aug 2026 · Vitamin C · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 25 Aug 2026 · Vitamin A · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 28 Jul 2026 · recommends · Facebook ↗
      Recommends Vitamin D, noting it regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity, and correcting deficiency may slow epigenetic aging.
    • 22 Jul 2026 · neutral · YouTube ↗
      Uses Vitamin D3 as an example of a supplement that an AI model could track to see its impact on other metrics like glucose levels.
    • 29 Jun 2026 · Vitamin K · neutral · Facebook ↗
      Mentions that kale delivers vitamin K, a micronutrient many diets fall short on.
    • 26 Jun 2026 · recommends · Facebook ↗
      Recommends Vitamin D, explaining that it regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity.
    • 15 Jun 2026 · neutral · Instagram ↗
      Combining omega-3s with vitamin D and exercise has an additive effect, translating to ~3 months of slowed biological aging.
  • Andrew Huberman · Vitamin D · neutral
    • 21 Sep 2026 · neutral · YouTube ↗
      Notes that most people are probably deficient in vitamin D and benefit from supplementing, but there's no point in doing it unless you're deficient for most things.
    • 7 Aug 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning for longevity.
    • 7 Aug 2026 · Vitamin K · uses · X ↗
      Takes 90 mcg of Vitamin K2 in the morning for longevity.
    • 20 Jul 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 20 Jul 2026 · recommends · YouTube ↗
      States that Vitamin D is one of the critical nutrients with the best evidence for cognitive function and reducing the risk of dementia.
    • 13 Jul 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning.
    • 13 Jul 2026 · Vitamin K · uses · X ↗
      Takes 90 mcg of Vitamin K2 in the morning.
    • 12 Jul 2026 · uses · X ↗
      He takes 5,000 IU of Vitamin D3 in the morning for overall health.
    • 12 Jul 2026 · Vitamin K · uses · X ↗
      He takes 90 mcg of Vitamin K2 in the morning for overall health.
    • 6 Jul 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning.
    • 6 Jul 2026 · Vitamin K · uses · X ↗
      Takes 100 mcg of Vitamin K2 in the morning.
    • 22 Jun 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning for general health.
    • 22 Jun 2026 · Vitamin K · uses · X ↗
      Takes 90 mcg of Vitamin K2 in the morning for general health.
    • 17 Jun 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 every day for longevity.
  • Peter Attia · Vitamin D · uses
    • 4 Jan 2026 · uses · YouTube ↗
      Lists vitamin D as one of her staple supplements.
    • 16 Nov 2025 · neutral · YouTube ↗
      Notes that several studies show patients taking vitamin D can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
    • 6 Aug 2025 · neutral · YouTube ↗
      States that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin D for both sexes.
    • 6 Aug 2025 · Vitamin A · neutral · YouTube ↗
      Notes that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin A for male mice.
    • 3 Aug 2025 · neutral · YouTube ↗
      Uses vitamin D as an example of how people might dismiss its efficacy due to failed clinical trials that didn't adjust the dose or measure levels.
    • 20 Jul 2025 · neutral · YouTube ↗
      In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin D for both sexes.
    • 20 Jul 2025 · Vitamin A · neutral · YouTube ↗
      In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin A for male mice.
    • 10 Jul 2025 · neutral · YouTube ↗
      Suggests that supplementing with lots of vitamin D might help overcome the negative effects of phenytoin on bone health by improving calcium absorption, though he is unaware of studies on this.
    • 9 Jul 2025 · recommends · YouTube ↗
      Recommends Vitamin D3 as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 800 to 1,000 IU, which can be obtained through sunlight or supplementation.
    • 6 Jul 2025 · neutral · YouTube ↗
      Suggests that supplementing with lots of vitamin D might overcome the negative effects of phenytoin on bone health by counteracting increased catabolism of vitamin D and subsequent decreased calcium absorption.
    • 3 Jul 2025 · Vitamin C · stopped · YouTube ↗
      Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
    • 29 Jun 2025 · Vitamin C · stopped · YouTube ↗
      Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
    • 29 Jun 2025 · Niacin · uses · YouTube ↗
      Peter Attia's AVIA Skincare vitamin C serum also contains niacinamide, which is useful to apply to the skin right after washing.
    • 8 Jun 2025 · recommends · YouTube ↗
      Recommends vitamin D for people who tend to be vitamin D deficient, such as those living in Portland, Oregon.

RAL Summary

Members OnlyTier 2 for Energy

Vitamin D at a full dose reduced fatigue in several controlled trials, mainly in people low in it [2][1], and over 15,000 reviews are 82% positive, which meets the rules for this tier.

Where the evidence disagrees: 68 of the 165 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Nervous system, Musculoskeletal system, Immune system, Metabolic system

Combine with: For thyroid support, pair this multivitamin with a targeted selenium source (such as selenomethionine, about 100-200 mcg total daily intake from all sources) to support T4-to-T3 conversion and protect the thyroid from oxidative stress. Add extra vitamin D3 with K2 if blood levels are low, since deficiency is common in autoimmune thyroid conditions. Consider zinc and iron only if lab testing shows a deficiency, as iron and ferritin status affect thyroid hormone production. L-tyrosine or an ashwagandha extract may offer additional support in some people, but ashwagandha can raise thyroid hormone levels, so use it cautiously. Omega-3 fish oil can help manage inflammation. Avoid excess iodine or kelp unless advised, and take meds such as a med separated from calcium, magnesium, and multivitamins by about 4 hours. Always consult a healthcare provider and check TSH, free T3/T4, and antibodies before supplementing.

Possible side effects: Large single doses of niacin have been linked to fatigue, stomach upset and flushing, mostly at doses far above this product. Store summaries mention some dislike of the smell and taste.

Supplement Facts

Vitamin A 1050 mcg · Vitamin C 250 mg · Vitamin D 50 mcg
Supplement Facts
Serving Size Two Capsules
Servings Per Container 30
Amount Per Serving% Daily Value
Vitamin A1,050 mcg
Vitamin C250 mg
Vitamin D50 mcg
Vitamin E16.5 mg
Vitamin K200 mcg
Thiamin50 mg
Riboflavin12 mg
Niacin80 mg
Vitamin B620 mg

Other ingredients: Hypromellose Capsule, Calcium Laurate, Dicalcium Phosphate.

Directions: Take 2 capsules daily or as recommended by your health-care practitioner.

Label source: Reverseagelab · Report a label change

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Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.