Thorne Buffered C Powder Review
Product Focus: Occasional Heartburn: Fast ReliefAlso covers:Digestion
Tier ⓘ
Tier 4 · Rank 5
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 5 within Tier 4 for Occasional Heartburn: Fast Relief; 14 of 14 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
15 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Biohacker Mentions
0 of 10
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Study, Trial or Testing Result Summary
Members Only48 human studies · 34 improved
1 of these 48 human studies gave the ingredient by drip, not by mouth.
48 human studies34 improved11 no effect363,452 people studied
Calcium and magnesium have the most direct support for fast heartburn relief, but mostly as calcium carbonate or as antacid mixtures, and the label here does not name the forms used. In small placebo trials, a single 420 milligram dose of calcium carbonate lowered acid in the food pipe and eased heartburn [1], and calcium carbonate gum or chewable tablets helped within 15 to 30 minutes [2]. A calcium and magnesium antacid raised stomach pH in about 6 minutes versus 240 on placebo, though the effect wore off sooner than acid-reducing drugs [3][4]. For frequent heartburn, as-needed calcium carbonate did worse than a daily acid-reducing drug [5]. Magnesium is mostly studied alongside aluminium. Such mixtures helped pregnant women [6][7], but one trial in indigestion found no benefit over placebo [8]. The vitamin C dose is above the daily recommended limit, so members may take less. No study tested vitamin C for everyday heartburn. The trials looked at irritation from a throat screening stain [9][10]. One small trial found that vitamin C mixed with nitrous acid increased acid reaching the throat [11]. Potassium showed no effect on reflux [12]. Animal and cell studies are never counted.
See all 48 studies →Hide the studies
- In a review of nine small trials in pregnant women, drug treatments including a magnesium-aluminium antacid with simethicone gave complete heartburn relief more often than placebo or no treatment, though evidence was limited.Interventions for heartburn in pregnancy.
- A review of nutrition trials in children with cerebral palsy found magnesium helped constipation but did not assess heartburn relief.Dietary and nutritional interventions in children with cerebral palsy: A systematic literature review.
- In about 2,965 patients having iodine-stained esophageal screening, a vitamin C spray cut acute side effects, and with the weaker iodine it also reduced heartburn within one week, compared with distilled water; this is heartburn caused by the iodine stain, not everyday heartburn.Effectiveness of Vitamin C Solution in Reducing Adverse Reactions Caused by Painless Lugol Chromoendoscopy: A Multicente…
- In 276 adults with indigestion, one month of a simethicone, charcoal and magnesium oxide combination lowered overall symptoms and epigastric burning more than placebo.Efficacy of a simethicone, activated charcoal and magnesium oxide combination (Carbosymag®) in functional dyspepsia: res…
- In 240 patients having iodine-stained esophageal screening, a 20 mL spray of 2% vitamin C lowered acute and late symptom scores versus saline, and caused less acid regurgitation or heartburn than sodium thiosulfate (33% vs 15%); this is irritation from the iodine stain, not everyday heartburn.The safety and efficacy of 2% vitamin C solution spray for relief of mucosal irritation caused by Lugol chromoendoscopy:…
- In 155 adults with frequent heartburn, as-needed calcium carbonate antacid for 12 weeks worked less well than twice-daily effervescent ranitidine, with more rescue antacid use and less healing of the oesophagus (29% vs 55%), though quality of life improved with both.Managing heartburn at the 'base' of the GERD 'iceberg': effervescent ranitidine 150 mg b.d. provides faster and better h…
- In 100 pregnant women with heartburn, a magnesium-aluminium antacid gel for two weeks worked about as well as an alginate-based product, with 88% improving in heartburn frequency versus 80%.Efficacy of alginate-based reflux suppressant and magnesium-aluminium antacid gel for treatment of heartburn in pregnanc…
- In 97 patients with gastritis, esophagitis or upper abdominal complaints, a magnesium and aluminium hydroxide antacid with smectite beat an aluminium hydroxide antacid on pain relief, speed of effect and heartburn over four weeks.[Antacid therapy of upper abdominal symptoms. Double-blind study on the effect and tolerance of 2 antacids in gastritis …
- In 90 people with acid reflux disease, adding magnesium-containing mineral water to standard treatment for a month improved indigestion and pain more than standard treatment alone.Application of mineral waters in the complex treatment of patients with gastroesophageal reflux disease.
- In 89 people with nonulcer indigestion, four weeks of an aluminum-magnesium antacid did not relieve symptoms compared with placebo.Antacids reduce Campylobacter pylori colonization without healing the gastritis in patients with nonulcer dyspepsia and …
- In 89 people with reflux not helped by standard drugs, a regimen including magnesium aluminum carbonate gave the best improvement in heartburn sensation compared with a herbal decoction.Efficacy evaluation and exploratory analysis of influencing factors of Banxia Houpu Decoction in the treatment of refrac…
- In 80 children with reflux, 8 weeks of domperidone plus magnesium and aluminum hydroxide fully cleared symptoms in 16 of 20 children, versus 7 of 20 on placebo.Domperidone plus magnesium hydroxide and aluminum hydroxide: a valid therapy in children with gastroesophageal reflux. A…
- In 72 infants with regurgitation, two weeks of magnesium alginate lowered reflux symptom scores about as well as thickened formula, at slightly lower cost.Magnesium Alginate in Gastro-Esophageal Reflux: A Randomized Multicenter Cross-Over Study in Infants.
- In 64 infants with reflux, magnesium alginate plus simethicone reduced symptom scores more than thickened formula or reassurance alone over up to 2 months.Effect of magnesium alginate plus simethicone on gastroesophageal reflux in infants.
- In 50 adults with throat reflux, 2 months of magnesium alginate suspension reduced symptoms and signs about as much as a med 20 mg daily.Read the study on PubMed (35032204) →
- In 44 people with reflux, 23 percent reported good relief on a magnesium-aluminium antacid gel over two 15-day periods, compared with 84 percent on Liquid Gaviscon.A comparative crossover study on the treatment of heartburn and epigastric pain: Liquid Gaviscon and a magnesium--alumin…
- In 37 people with chronic dyspepsia, an aluminium-magnesium antacid plus antispasmodic tablet relieved heartburn earlier and more than aluminium hydroxide alone over 4 weeks.A comparison of an antacid plus antispasmodic combination and aluminium hydroxide in dyspepsia.
- In 30 patients with stomach or duodenal ulcers, antacids containing 1.6 g magnesium hydroxide and 1.6 g aluminium hydroxide daily relieved heartburn and pain, but less than when triletide was added.Controlled clinical assessment of the efficacy and tolerance of triletide versus antacids in patients with gastric and d…
- In 26 adults with frequent meal-related heartburn, a single 420 mg dose of calcium carbonate lowered acidity in the oesophagus and reduced heartburn severity compared with placebo.Synergy between low-dose ranitidine and antacid in decreasing gastric and oesophageal acidity and relieving meal-induced…
- In 24 adults given a heartburn-provoking meal, single doses of calcium carbonate gum or chewable tablets reduced heartburn and raised oesophageal pH within 15-30 minutes compared with placebo, with the gum lasting longer than the tablets.Clinical effectiveness of a new antacid chewing gum on heartburn and oesophageal pH control.
- In 24 healthy volunteers, a single dose of a calcium and magnesium carbonate antacid raised stomach pH within the first 30 minutes compared with no treatment, but the effect was short-lasting.Comparison of two antacid preparations on intragastric acidity--a two-centre open randomised cross-over placebo-controll…
- In 24 adults with a history of reflux, a chewing gum containing calcium carbonate and other ingredients lowered heartburn and acid reflux scores after a trigger meal compared with placebo gum.Effect of GutsyGum(tm), A Novel Gum, on Subjective Ratings of Gastro Esophageal Reflux Following A Refluxogenic Meal.
- In 20 adults with chronic cough, the antacid Maalox reduced cough-like efforts triggered by deep lung emptying within minutes, while placebo did not, though this study measured cough rather than heartburn.Effect of an anti-reflux medical device in the control of deflation cough: A placebo-controlled comparative study with a…
- In 11 healthy volunteers and 9 people with chronic reflux, 4 days of potassium nitrate (dose not stated) did not change stomach acidity, acid reflux, or reflux symptoms compared with placebo, though it slightly improved how well the food pipe contracted.Effects of dietary nitrate on oesophageal motor function and gastro-oesophageal acid exposure in healthy volunteers and …
- In 16 healthy fasting volunteers, a single 1360 mg dose of calcium-magnesium carbonate antacid raised stomach pH above 3 in a median of 5.8 minutes versus 240 minutes with placebo, acting faster than two acid-reducing drugs but wearing off sooner.Comparison of the effect of the antacid Rennie versus low-dose H2-receptor antagonists (ranitidine, famotidine) on intra…
- In 15 healthy people given a meal with an infused solution of nitrous acid plus vitamin C, reflux-related relaxations of the esophageal sphincter increased and acid exposure in the esophagus rose compared with a plain acid control.Nitrogenous chemicals generated from acidification of saliva influence transient lower oesophageal sphincter relaxations…
- In 15 patients with reflux-related eye symptoms, a month of magnesium alginate eye drops and tablets brought tear film measures back to normal values.Ocular Surface Disease as Extraesophageal Gastroesophageal Reflux Disease Manifestation: A Specific Therapeutic Strategy…
- In people with nonulcer dyspepsia, calcium carbonate was linked to more reflux symptoms in those with a stomach lining condition (multifocal atrophic gastritis) once their Helicobacter pylori infection was cleared.Increased reflux symptoms after calcium carbonate supplementation and successful anti-Helicobacter pylori treatment.
- A new alginate and calcium carbonate liquid formed a raft and stayed in the stomach about as well as an existing Gaviscon liquid; the study did not measure heartburn relief in people.Alginate-antacid combinations: raft formation and gastric retention studies.
- In people with reflux oesophagitis over 10 weeks, Gastrocote reduced heartburn days from baseline, though acid exposure was no lower than with cimetidine and the combination with cimetidine worked best.Combined cimetidine-alginate antacid therapy versus single agent treatment for reflux oesophagitis: results of prospecti…
- A single 1.5 gram dose of the aluminium-magnesium antacid almagate was effective for reflux damage to the food pipe in a double-blind crossover trial, with both tested formulations performing equally.Effectiveness of almagate in gastroesophageal reflux disease: a post-hoc analysis of a randomized cross-over double-blin…
- In infants under one year with reflux, giving a small formula feeding before a standard magnesium-aluminum antacid dose improved how well the antacid buffered stomach acid.Antacid and formula effects on gastric acidity in infants with gastroesophageal reflux.
- In 12 healthy volunteers, a single 20 mL dose of an alginate antacid containing calcium carbonate significantly reduced food and acid reflux into the oesophagus after a test meal compared with no treatment.Effect of alginate and alginate-cimetidine combination therapy on stimulated postprandial gastro-oesophageal reflux.
- In 169 people with heartburn, the aluminum-magnesium antacid almagate was effective, and most patients were symptom free by the end of a 2-week open trial with no control group.Treatment of gastric pyrosis with almagate in patients with and without endoscopically demonstrable duodenal ulcer. A mu…
- In 89 people with high blood pressure taking a combined pill with 600 mg potassium chloride for 9 months, heartburn was the second most common symptom reported, after headache. This study did not test heartburn as a treatment goal.Oxprenolol slow-release with cyclopenthiazide KCl in the treatment of essential hypertension. A multicentre general prac…
- In 61 adults with fatty liver disease and stomach or bowel symptoms, drinking 400 mL of a magnesium-containing mineral water daily for six months improved lower bowel symptoms, which worsened after stopping; the study had no placebo group and did not test heartburn directly.The use of bicarbonate-sulphate-calcium-magnesium and sodium-low drinkable water improves functional gastrointestinal sy…
- In 60 elderly patients with reflux, an alginate product (Geviskon) relieved heartburn, regurgitation, cough and sore throat more completely and faster than an aluminum-magnesium antacid over 7 days.[Using gaviscon preparation for relief of esophageal, extraesophageal syndromes and functional dyspepsia in elderly pati…
- In 49 healthy adults, a combined esomeprazole and magnesium hydroxide tablet raised stomach pH to 4 faster than enteric-coated esomeprazole alone over seven days of dosing.Pharmacokinetics and Pharmacodynamics of a Fixed-Dose Combination of Esomeprazole and Magnesium Hydroxide Compared to th…
- In a large cohort of about 356,000 people, harder tap water was linked to lower risk of some digestive conditions such as dyspepsia, but moderately hard water was linked to higher risk of reflux disease and peptic ulcer.Water hardness and digestive diseases: a large-scale population-based prospective cohort study.
- In a case-control study of 537 people in China, higher dietary vitamin C intake was linked to lower risk of reflux esophagitis, but this was a food intake association rather than a supplement trial.Dietary intake and risk for reflux esophagitis: a case-control study.
- In a case-control study of 431 people, those who ate diets high in vitamin C had lower odds of reflux disease, Barrett esophagus and esophageal cancer, but this was an observational association from diet, not a supplement trial.Obesity and lifestyle risk factors for gastroesophageal reflux disease, Barrett esophagus and esophageal adenocarcinoma.
- In a survey of 382 anemia patients, vitamin C use had mixed outcomes for treatment side effects such as heartburn, and no clear benefit was shown.Impact of Side Effects on Anemia Therapy Compliance.
- In a small study of dyspepsia patients, those with organic dyspepsia ate less vitamin C than matched controls, and functional dyspepsia patients also had lower vitamin C intake, but the study measured diet only and did not test vitamin C for relief.Food and nutrient intakes and eating patterns in functional and organic dyspepsia.
- In 100 outpatients with throat reflux, two months of magnesium alginate significantly reduced voice problems, swallowing trouble and cough on a visual scale, with no side effects reported.Magnesium alginate in patients with laryngopharyngeal reflux.
- In 15 children with reflux treated with magnesium and aluminium hydroxide for eight weeks, 12 were cured and 3 improved, and acid reflux measured on pH monitoring was significantly reduced.[Magnesium hydroxide and aluminum hydroxide in the treatment of gastroesophageal reflux].
- Drinking a magnesium-rich sulphate mineral water was linked to fewer symptoms and better heart measures in people with mild gastroesophageal reflux and heart-related symptoms.[Magnesium-containing mineral waters in the treatment of patients with cardial manifestations of gastroesophageal reflux…
- In a lab and small test in normal people, acidic stomach contents helped an alginate and magnesium antacid mixture form a protective floating barrier against reflux, while plain water did not.Use of 111In-labeled alginate to study the pH dependence of alginic acid anti-esophageal reflux barrier.
- A 1994 Ukrainian report describes an antacid containing alginic acid and magnesium, used with antisecretory drugs for dyspepsia and reflux, that forms a protective floating layer in the stomach, but the abstract gives no patient numbers or outcome figures.[The use of 3rd-generation antacid preparations for the treatment of patients with nonulcerous dyspepsia and peptic ulce…
Review Totals and Summary
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Biohacker Summary
Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it
Magnesium is the main ingredient, and most of the panel recommends or uses it, with the rest staying neutral. Sleep is the top reason, and several take 400 mg of magnesium threonate before bed, while others mention glycinate or other types and one suggests threonate, biscinate or torate for deep sleep. Others use it in electrolyte drinks around workouts or fasting, or recommend it for blood pressure, muscle cramps, constipation, migraines and bone health, and one panelist said the sleep evidence is not yet consistent. Two panelists warned that labels can make the magnesium dose look larger than it really is, and one pointed out that a standard blood test can miss low levels. Potassium and vitamin C are smaller ingredients in this product, and the panel mostly mentions them for electrolytes and for collagen support.
See all 10 biohackers →Hide the biohackers
Dr. Mark Hyman · Magnesium · uses
- Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
- Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
- Warns that potassium bromate, a dough conditioner banned in the EU, UK, and Canada, is still allowed in U.S. bread.
- Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
- Recommends magnesium as a basic supplement during detoxification to support pathways, help with constipation, and provide electrolytes.
- Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
- Recommends Magnesium Breakthrough Advanced 10 from Biooptimizers, which contains 10 bioavailable forms and 550 mg of elemental magnesium, to support restful sleep, restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
- Mentions topical vitamin C as an antioxidant that can help skin with aging.
- Mentions that what they do when a cold comes on is not just vitamin C.
- Recommends ensuring adequate vitamin C intake on a regular basis for immune support, stating it's important for healthy immune function despite mixed data on its effectiveness for colds.
- Has recommended magnesium breakthrough from bioptimizers for years and now uses Magnesium Breakthrough Advanced 10 as part of his evening routine, especially during periods of travel, training, and higher stress, to support sleep, muscle recovery, and metabolic health.
- Mentions that vitamin C was the very first vitamin discovered, isolated, and synthesized in 1932, and its deficiency caused scurvy.
- Recommends correcting nutrient deficiencies with magnesium.
Dave Asprey · Magnesium · neutral
- Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
- Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
- Recommends taking vitamin C for better skin health.
- States that magnesium can affect how the body responds to a supplement.
- States that currently, he is only taking vitamin C and vitamin D.
- Recommends fixing sleep with 300mg of Magnesium 101 before bed if diet and exercise aren't melting stubborn belly fat.
- Dave Asprey says his daily routine includes magnesium as part of a carefully developed combination for longevity.
- Recommends magnesium glycinate for sleep, stating that trials show it helps people fall asleep about 17 minutes faster and that he finds it incredibly effective.
- Mentions magnesium glycinate as one of the five gut-friendly, extensively researched ingredients in Kill Switch that helps with natural sleep.
- Dave Asprey recommends Magnesium Glycinate for sleep, noting human studies show it helps people fall asleep faster, is safe, and works on a fundamental aspect of health, unlike magnesium oxide which acts as a laxative.
- Dave Asprey recommends adding 300 or 400 mg of magnesium glycinate before bed to improve deep sleep quality, support growth hormone release, and burn visceral fat while asleep.
- Dave Asprey reflects on how new research clarifies the mechanism behind IV vitamin C's anti-cancer effect, vindicating a decades-old idea that was dismissed for the wrong reasons.
- Mentions magnesium glycinate as one of the extensively researched ingredients in Kill Switch that helps with natural sleep.
- Notes that plain Vitamin C isn't enough and that most people never think to check for a specific ingredient that makes it work.
Dr. Eric Berg · Magnesium · neutral
- Dr. Eric Berg states that magnesium supports energy, muscle function, and sleep, and that most of it is stored inside cells, making deficiencies harder to detect with a standard blood test.
- States that people need more potassium than any other mineral, yet most people aren’t getting enough.
- Notes that magnesium could also be a factor in preventing muscle cramps.
- Explains that potassium is essential for peristalsis, the pumping action through the colon, and without it, things can sit there, leading to constipation.
- Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
- Recommends magnesium, specifically magnesium glycinate, stating it is key for D3 and K2 to work and is probably more important than calcium for building bone.
- Recommends increasing magnesium to restore balance and support healthy blood pressure.
- Warns that bone loss cannot be fixed with just calcium, as bone is primarily collagen with other essential minerals.
- Explains that the normal requirements for potassium are 4,700 mg every single day, and that very few people get half of that amount. They describe potassium's role in the sodium potassium pump, which is essential for cellular electricity, muscle contraction, and heart function. Deficiency can lead to tiredness, muscle cramps, heart palpitations, or rising blood pressure.
- Recommends increasing potassium to restore balance and support healthy blood pressure.
- Dr. Berg states that Vitamin C helps fight biofilms and is essential for making collagen in gums, teeth, and capillaries.
- Dr. Eric Berg suggests that magnesium could help support deeper, more restful sleep.
- Recommends Magnesium Glycinate, noting that the combination of magnesium and glycine is helpful for connective tissue, sleep, and reducing stress.
- Recommends Vitamin C as a cofactor, especially for collagen.
Ben Greenfield · Magnesium · uses
- Uses magnesium during surgery because it is neuroprotective.
- States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Mentions magnesium as part of a bare-minimum protocol.
- Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
- Mentions vitamin C as part of a bare-minimum protocol.
- Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
- Recommends supplementing with magnesium threonate if one is low in magnesium, as it crosses the blood-brain barrier and is demonstrated to increase hippocampus plasticity, theoretically making one smarter and improving memories.
- Uses Magnesium Breakthrough from BIOptimizers as part of their daily stack, taking four capsules in the evening to support relaxation, recovery, and a good night of sleep.
- Notes that IV vitamin C has been used for decades for cancer patients with almost no standardization and that he receives many questions about its effectiveness and combination with chemo.
- Recommends Celtic Sea Salt's new electrolyte drink "Hydrate" for replacing electrolytes and trace minerals lost through sweat, noting it contains 70 naturally occurring trace minerals, plus magnesium, taurine, and potassium.
- Recommends Celtic Sea Salt's new electrolyte drink 'Hydrate' for replenishing electrolytes and trace minerals lost through sweat, noting it contains 70 naturally occurring trace minerals, magnesium, taurine, and potassium, with no added sugar, artificial colors, or synthetic ingredients.
- Had heart palpitations when he was really overdoing magnesium, not knowing what he was taking.
Dr. Rhonda Patrick · Magnesium · neutral
- Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
- Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
- Mentions magnesium as an important nutrient component for testosterone.
- Warns that some supplement companies mislead consumers by listing the total compound weight of magnesium citrate as the elemental magnesium dose, when the actual elemental magnesium content is much lower, potentially around 44-66 milligrams.
- States there is not yet strong, consistent evidence that magnesium supplementation reliably improves sleep, noting that while some meta-analyses suggest it can improve sleep quality scores, sleep efficiency, and sleep duration, individual studies are inconsistent and several have found no meaningful effect.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- States that magnesium may help modestly lower blood pressure by playing an important role in regulating vascular tone and influencing calcium signaling, with studies showing a reduction in systolic and diastolic blood pressure by 2 mmHg at a dose of around 370 mg/day for about 3 months.
- Recommends considering magnesium to improve mood.
- Recommends Magnesium, stating that roughly half of Americans don’t get enough and it is a cofactor for over 300 biological processes, including DNA repair and energy production.
- Mentions that kale delivers magnesium, a micronutrient many diets fall short on.
- Mentions that kale delivers calcium, a micronutrient many diets fall short on.
- Recommends Magnesium, stating it is a cofactor for over 300 biological processes, including DNA repair, energy production, and sleep regulation.
- Recommends getting enough potassium, noting that most people get too much sodium and not enough potassium.
- Recommends nutrients like vitamin C for men to prioritize sperm mitochondrial health.
Thomas DeLauer · Magnesium · uses
- Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
- Uses Element's cans which contain 100 milligram potassium, finding that electrolytes help his workout performance.
- Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
- Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
- Uses Element's 100 mg potassium cans first thing in the morning to prime his day and help with workout performance.
- Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
- Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
- Recommends magnesium, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
- Notes that modern agricultural practices have led to soils depleted of trace minerals like magnesium, resulting in widespread magnesium deficiency.
- Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
- Recommends taking some magnesium glycinate tonight to help calm down and sleep.
- Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
- Mentions that magnesium in pumpkin seeds relaxes bronchial smooth muscle.
- Compares magnesium content, stating bananas have 32mg and pumpkin seeds have 156mg per ounce, a 5x difference.
Siim Land · Magnesium · recommends
- States that Magnesium can be a useful addition for some people for sleep.
- Recommends taking vitamin C with collagen to support joint collagen synthesis.
- States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
- Recommends magnesium for sleep, especially deep sleep, and suggests trying better types like Threonate, Biscinate, or Torate, referencing a study where magnesium supplementation improved deep sleep.
- Recommends Magnesium for blood pressure, migraines and deficiency, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Magnesium as one of 15 supplements backed by human studies.
- States that magnesium is a fundamental mineral governing over 600 enzymes and metabolic reactions, and recommends that most people need at least 400-500 mg/d for health, with some needing up to 600 mg/d.
- Lists seafood and pumpkin seeds as sources of Magnesium.
- Lists dairy and sardines as sources of Calcium.
- Lists sauerkraut and fruit as sources of Vitamin C.
- Lists potatoes and fruit as sources of Potassium.
- Thinks magnesium has some of the strongest evidence and is worth considering.
- Notes that Vitamin C is one of several supplements with human evidence.
- Recommends taking magnesium, specifically glycinate and threonate forms, 1 to 2 hours before bed for sleep benefits, noting that glycinate promotes relaxation and threonate crosses the blood-brain barrier for sleep quality and cognitive function.
Andrew Huberman · Magnesium · neutral
- Discusses Magnesium Threonate as a tool for falling asleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Confirms that magnesium is absolutely important for cognitive function, noting studies show those with lower magnesium intakes tend to perform less well on cognitive function tests, and it's related to brain changes over time and dementia risk.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- He takes 400 mg of Magnesium L-Threonate from Double Wood before bed for sleep.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium L-threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes a multivitamin every day for longevity.
- Uses Element, which contains potassium in the correct ratios, to ensure proper hydration and electrolyte intake for brain and body function.
- Mentions potassium as an electrolyte.
Bryan Johnson · Magnesium · uses
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- He takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium L-threonate before bed for sleep.
- He takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium threonate before bed for sleep.
- Recommends calcium as a mineral that, along with phosphorus, magnesium, and boron, is deposited to fortify the bone structure after the collagen scaffold is in place.
- Agrees that a little extra calcium is probably okay, especially for women, to really hit home for bone mineral density.
- Uses Vitamin C as an example of how it would be great if people knew that when they took it, it had a measurable amount and wasn't polluted, which is what Brian ensures with his products.
- Applies vitamin C after showering.
Peter Attia · Magnesium · neutral
- Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
- States there is some evidence that increasing dietary potassium through potassium-rich foods like bananas and potatoes, rather than supplements, can lower blood pressure.
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
- Recommends magnesium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 300 to 500 milligrams as a minimum, and personally aims for about a gram of supplemental magnesium.
- Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
- Recommends magnesium for optimizing bone mineral density, suggesting a daily intake of 300 to 500 milligrams as a minimum, but personally aims for about a gram.
- Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
- Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
- Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
- Recommends calcium for bone health, stating that teenagers probably need about 1000 milligrams a day.
- Discusses bone acting as a reservoir for calcium and how resorption and formation release calcium into the blood when needed.
- States that vitamin C deficiency is associated with an elevated risk of cataract, but supplementation to supranormal levels has not been shown to protect against cataract formation.
- Mentions the elimination of scurvy through the work of James Lind and the eventual understanding that it was due to vitamin C, initially thought to be just citrus.
RAL Summary
Members OnlyTier 4 for Occasional Heartburn: Fast Relief
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Members OnlyBody systems · Combine with · Possible side effects
Body systems: Digestive system
Possible side effects: No major side effects were reported in the antacid trials. Vitamin C combined with nitrous acid increased acid reaching the throat in one small trial, and heartburn was reported with meds that contained potassium chloride.
Supplement Facts
Vitamin C 2.35 g · Calcium 350 mg · Magnesium 350 mg
Supplement Facts
Serving Size 5.7 Gram(s)
Servings Per Container 42
Amount Per Serving% Daily Value
| Vitamin C | 2.35 g | |
| Calcium | 350 mg | |
| Magnesium | 350 mg | |
| Potassium | 99 mg |
Directions: Suggested use: Mix 1 scoop with at least 8 ounces of water daily or as recommended by your health-care practitioner.
Barcode (UPC) 693749155027 · Label source: NIH label database · Report a label change
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More occasional heartburn: fast relief products
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Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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