Thorne Clear Focus Review
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Study, Trial or Testing Result Summary
Members Only3 human studies · 3 improved
No human study has measured whether this product, or either of its ingredients, turns back biological age. Sage extract is present at 333 milligrams, matching the dose used in the main trial. In that placebo-controlled trial, 70 women with polycystic ovary syndrome took 330 milligrams of sage extract daily for eight weeks. They had lower blood fats and a lower marker of oxidative stress than the placebo group, while other cholesterol measures did not change [1]. Other studies did not test sage extract by mouth on its own. In 34 women with advanced breast cancer, a food mix containing sage among many other ingredients improved quality of life and reduced high free radical activity, but the effect of sage alone cannot be separated [2]. A skin cream with a small amount of one compound isolated from sage improved facial wrinkles over 12 weeks compared with a control, but this tells little about a sage capsule [3]. No human studies were found on L-tyrosine for aging or cell repair, so its role here is unknown. Animal and cell studies are never counted.
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- In 70 women with polycystic ovary syndrome, 330 mg of sage extract daily for eight weeks lowered triglycerides and an oxidative stress marker (malondialdehyde) compared with placebo, without changing other cholesterol measures.Exploring the therapeutic impact of Salvia officinalis on lipid and oxidative stress markers in patients with polycystic…
- In 34 women with advanced breast cancer, a food mix that included sage among many other ingredients for three months improved quality of life scores and reduced the share with high free radical activity compared with the start, so the effect of sage alone cannot be separated.Role of multi-component functional foods in the complex treatment of patients with advanced breast cancer.
- A 0.02% sclareol cream, a compound isolated from sage, improved facial wrinkles compared with control over 12 weeks in a clinical trial, though the study also relied heavily on cell and skin-model tests.Sclareol isolated from Salvia officinalis improves facial wrinkles via an antiphotoaging mechanism.
Review Totals and Summary
Members OnlyWhat buyers say
No written reviews read yet.
Biohacker Summary
Members Only0 of 10 recommend it
Five of the ten panelists spoke about sage, the main ingredient in this product, and the group leans positive: three recommend it and two are neutral. They mostly talk about sage as a food herb or tea, such as adding it to meat, burgers, salad, or ground into coffee, and as a tea for coughs or sore throats. The reasons given include helping cells use fat, lowering inflammation, antioxidant compounds similar to those in green tea, and longevity, since people in long-lived regions drink sage tea and eat wild herbs. One panelist pairs it with garlic and thyme, another with marjoram, rosemary, and thyme. No one gave a dose, no one said they stopped, and the one caution is that a possible benefit for long COVID has not been proven.
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Dr. Eric Berg · Sage · recommends
- Recommends adding sage to meat when cooking on the grill.
- Recommends adding sage to meals for its anti-cancer properties to potentially avoid colon cancer.
- Recommends putting garlic, thyme, and sage on meat or salad.
- Recommends sage as an herbal spice with special compounds.
- Recommends consuming sage as a natural herbal a med for candida.
- Lists sage as a natural remedy to get rid of gout.
- Recommends adding sage to meals to help with the detoxification process.
- Mentions sage as a source of a phytonutrient that can help increase nitric oxide.
- Recommends sage as a natural a med for infections.
- Recommends taking sage to help with excessive sweating, as it contains rosemarinic acid and is rich in vitamin B1.
Thomas DeLauer · Sage · recommends
- Recommends marjoram, rosemary, thyme, and sage, noting evidence that they increase PPAR alpha, programming cells to be better at using fats and reducing inflammatory cytokines.
- Recommends sage as a good Mediterranean spice that can influence cells to utilize more fat by affecting PP alpha.
- Recommends adding Rosemary or Sage to a Mediterranean-style burger.
- Finds it interesting that Ikarians consume a high amount of sage tea, noting that sage has been shown to impact cells in terms of fat adaptation and utilization, and suggests it would be easy to integrate.
- Mentions Sage as one of the Mediterranean herbs used by Vikings.
- The study's dietary protocol included spices like sage.
- Recommends sage, noting it helps with fatty acid utilization and ppar alpha activation, allowing the body to become more fat adapted, especially when added to a higher fat ketogenic breakfast.
- Recommends sprinkling a little bit of finely ground sage powder, along with rosemary, thyme, and oregano, during a deep fasted state, especially during longer fasts, to activate ppar alpha and provide a satiation effect.
- Recommends consuming Mediterranean spices like rosemary, thyme, oregano, and sage prior to a fast because they contain hispigiline, which activates ppar alpha to aid in fat adaptation.
- Notes that hispiduline, a compound that aids in fat adaptation, can also be found in sage.
Dr. Mark Hyman · Sage · neutral
- Suggests that the plant sage, which has high levels of phytochemicals that inhibit enzymes in the tryptophan pathway, might be a natural cure for long COVID, though it has not yet been proven.
- Recounts discovering a wild sage bush in Icaria that has higher levels of catechins than green tea, which are considered longevity molecules.
- Describes drinking Wild Sage Tea, noting it has as many powerful phytochemicals as green tea, which are known to increase longevity.
- Dr. Mark Hyman, after visiting a blue zone, recommends wild sage tea for its high content of epigalactic catechins, which are detoxifying, anti-inflammatory, support the immune system, and activate longevity switches by upregulating glutathione.
- Describes drinking wild sage tea in a Blue Zone, noting it is full of epigallocatechins, powerful compounds found in green tea, and activates longevity switches.
- Used a sage wand with a smudge stick, a Native American way of clearing energy, to clear the heaviness in her house, which resulted in her daughter sleeping soundly.
- Notes that sage has good scientific evidence to help memory.
- A clairvoyant friend bought a sage wand from Whole Foods and used it to clear heavy energy from Dr. Mark Hyman's house, which Dr. Mark Hyman participated in due to desperation and low risk.
- Used a sage wand, also known as a smudge stick, in their house to clear heavy energy, describing it as a low-risk intervention with high potential gain.
Ben Greenfield · Sage · neutral
- Ben discusses the idea of putting ground sage in coffee, suggesting it would be a good idea.
- Notes that residents of a longevity zone in Italy consume high amounts of wild herbs including sage.
- Ben mentions sage tea is recommended for drying excess oils and preventing hands from sweating, similar to green tea, by soaking hands in it.
Dave Asprey · Sage · recommends
- Recommends sage, noting it decreases IL-6 and can be soothing as a tea for coughs or sore throats.
RAL Summary
Members OnlyTier 4 for Healthy Aging
Tier 2 needs over 100 mostly positive reviews and clear human evidence, but no reviews were counted. Two of the three sage studies did not test this extract: one used a food mix with many ingredients and one used a skin cream of a single isolated sage compound, leaving one small trial on aging markers. So it is graded Tier 4, lower than the rules alone gave.
- Emerging: not enough evidence to rank higher yet.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Cardiovascular system, Metabolic system, Nervous system
Possible side effects: No major side effects reported.
Supplement Facts
L-Tyrosine 500 mg · Sage extract 333 mg
| L-Tyrosine | 500 mg | † |
| Sage extract (leaf) | 333 mg | † |
Other ingredients: Hypromellose (derived from cellulose) capsule, Ascorbyl Palmitate.
Directions: Take 2 capsules daily or as recommended by your health-care practitioner.
Label source: Reverseagelab · Report a label change
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Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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