Thorne CoQ10 100 mg Review
Thorne CoQ10 100 mg is sold as a 60 count gelcap supply, with a serving size of one gelcap and 60 servings per container. The page describes the product as a way to support cardiovascular and neurological health, cellular energy production, and healthy aging with a well-absorbed form of CoQ10. CoQ10 is described as an essential nutrient for cellular energy production that supports heart, brain, and immune function, in addition to providing antioxidant support. The page states that Thorne CoQ10 contains coenzyme Q10 in the form of ubiquinone. CoQ10 is described as a nutrient found in the mitochondria of cells that provides support against oxidative stress and plays a role in the body's production of cellular energy. The page notes that CoQ10 is particularly supportive for the cells of the heart, liver, brain, kidney, and muscles, and that CoQ10 levels decline with age and can be depleted by certain medications. The listed benefits include support for energy level and exercise stamina, support for heart rhythm, blood vessel function, and healthy blood pressure, promotion of healthy aging through mitochondrial function, a role in protecting against oxidative stress by enhancing glutathione activity, and support for a healthy inflammatory response. The product is described as an optimally absorbed, proprietary, lipid-based, non-crystalline form of coenzyme Q10, with enhanced absorption over dry powder, oil, nanoparticle, and liposomal preparations. The page states the product has been third-party tested and certified to verify that what is in the package matches the label and contains no unsafe levels of contaminants such as heavy metals, pesticides, and microorganisms. The warnings section states the product is contraindicated for anyone with a history of hypersensitivity to its ingredients. It notes the monoglycerides are derived from soy but contain no soy protein. Pregnant users are advised to consult a health-care practitioner before use. The page reports no known adverse interactions or contraindications at publication date. The FAQ states the product may suit adults seeking support for cellular energy, cardiovascular health, brain function, and healthy aging, and that each softgel provides 100 mg of coenzyme Q10 as optimally absorbed, non-crystalline ubiquinone. The page also describes the difference between this ubiquinone product and Thorne Ubiquinol, noting the body can convert between both forms as needed.
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Study, Trial or Testing Result Summary
Members Only25 human studies · 19 improved
Each gelcap gives 100 mg of coenzyme Q10, and the record lists 200 mg a day, a full dose compared with the studies. In a four-year trial of 403 older adults low in selenium, 200 mg a day of coenzyme Q10 taken with selenium raised a selenium protein that was linked to longer telomeres, less inflammation, better quality of life and fewer deaths. This product does not contain selenium [1]. In 100 trained adults, 200 mg a day of the ubiquinol form for two weeks lowered oxidative damage after exercise, including damage to genetic material, compared with placebo [2]. In 40 patients with early sepsis, 200 mg a day lowered markers of inflammation and oxidative damage [3]. In 33 healthy adults, 50 or 150 mg a day for 12 weeks reduced wrinkles but did not change skin moisture [4]. A review of 20 trials in women with ovarian aging found coenzyme Q10 worked best among antioxidants for egg retrieval and pregnancy rates [5]. However, in 40 healthy older adults, 400 mg a day for 12 weeks raised blood levels but did not improve muscle energy, blood sugar control, fitness or body composition [6]. No study measured a reversal of biological age. Animal and cell studies are never counted.
See all 25 studies →Hide the studies
- Across 20 trials of 2617 women with ovarian aging, antioxidants raised egg retrieval and pregnancy rates, and coenzyme Q10 worked best, at about 30 mg a day for 3 months before ovarian stimulation.Antioxidants and Fertility in Women with Ovarian Aging: A Systematic Review and Meta-Analysis.
- In 403 older adults low in selenium, four years of coenzyme Q10 (200 mg a day) plus selenium raised selenoprotein P, which was linked to longer telomeres, less inflammation, better quality of life and lower death rates.Selenoprotein P increases upon selenium and coenzyme Q10 supplementation and is associated with telomere length, quality…
- In 124 patients with acute viral heart inflammation, coenzyme Q10 lowered inflammation and oxidative stress markers, and combining it with trimetazidine worked better than either alone.Combination Therapy With Coenzyme Q10 and Trimetazidine in Patients With Acute Viral Myocarditis.
- In 100 healthy trained adults, two weeks of ubiquinol (200 mg a day) lowered exercise-induced oxidative damage markers, including DNA damage (8-OHdG), compared with placebo.Short-term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: A ra…
- In 73 people with chronic fatigue syndrome, 8 weeks of coenzyme Q10 (200 mg a day) plus NADH reduced fatigue versus placebo, raised cellular energy (ATP) and NAD+/NADH, and lowered lipid peroxides.Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome?
- In 50 elderly patients having aortic valve surgery, ubiquinol (400 mg a day) from a week before to 5 days after surgery blunted the drop in blood coenzyme Q10 and the rise in a heart injury marker (troponin I) versus placebo.Ubiquinol supplementation in elderly patients undergoing aortic valve replacement: biochemical and clinical aspects.
- In 49 adults with diabetic nerve damage, 12 weeks of ubiquinone (400 mg a day) improved symptoms and nerve conduction and lowered lipid peroxidation versus placebo.The effect of ubiquinone in diabetic polyneuropathy: a randomized double-blind placebo-controlled study.
- In 40 patients with early sepsis, 200 mg of coenzyme Q10 daily for 7 days lowered levels of an inflammation marker (TNF-alpha) and an oxidative damage marker (MDA) and was linked to lower in-hospital deaths than the control group.Coenzyme Q10 improves the survival and reduces inflammatory markers in septic patients.
- In 40 healthy older adults (about 74 years old), 400 mg of coenzyme Q10 daily for 12 weeks raised blood levels but did not change muscle mitochondrial function, blood sugar control, fitness or body composition compared with placebo.Coenzyme Q10 supplementation raises plasma levels without improving mitochondrial function in older adults.
- In 36 patients with antiphospholipid syndrome, 200 mg of ubiquinol daily for 1 month improved blood vessel function and lowered markers of inflammation, clotting risk and oxidative stress compared with placebo.Ubiquinol Effects on Antiphospholipid Syndrome Prothrombotic Profile: A Randomized, Placebo-Controlled Trial.
- In 33 healthy adults, 12 weeks of daily water-soluble coenzyme Q10 (50 or 150 mg) reduced wrinkles and fine lines and improved skin smoothness compared with placebo, but did not change skin hydration.The effect of dietary intake of coenzyme Q10 on skin parameters and condition: Results of a randomised, placebo-controll…
- In 23 a med-treated adults with type 2 diabetes and poor artery function, 200 mg of coenzyme Q10 daily for 12 weeks improved blood vessel widening compared with placebo, while oxidative stress markers did not change.Read the study on PubMed (19228872) →
- In 23 moderately trained healthy men, 90 mg of coenzyme Q10 daily for 8 weeks did not improve maximal oxygen uptake, exercise workload, or exercise-related oxidative stress compared with placebo.Coenzyme Q10 supplementation and exercise-induced oxidative stress in humans.
- In 21 sedentary young men, 200 mg of coenzyme Q10 daily for 4 weeks raised blood levels but did not reduce muscle damage or oxidative stress after hard exercise compared with placebo.Coenzyme Q10 does not prevent exercise-induced muscle damage and oxidative stress in sedentary men.
- In 10 people with juvenile fibromyalgia, 100 mg of ubiquinol daily for 12 weeks improved fatigue scores and blood cholesterol levels.Increased oxidative stress and coenzyme Q10 deficiency in juvenile fibromyalgia: amelioration of hypercholesterolemia an…
- In 10 older men taking 200 mg of ubiquinol daily with a meal for 2 weeks, blood levels of Coenzyme Q10 rose, but markers of oxidative stress and cell energy did not change.Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men.
- In gas and oil industry workers with oxidative stress and impaired heart and nerve function, a short course of a coenzyme Q10-based supplement improved cardiovascular and psycho-emotional measures and normalized markers of oxidative stress in white blood cells.Coenzyme Q10-containing composition (Immugen) protects against occupational and environmental stress in workers of the g…
- In 41 volunteers, 2 months of a marine collagen and antioxidant blend including coenzyme Q10 improved skin elasticity, sebum production and dermal ultrasound markers, with no change in glutathione or coenzyme Q10 levels.Skin Antiageing and Systemic Redox Effects of Supplementation with Marine Collagen Peptides and Plant-Derived Antioxidan…
- In 36 hemodialysis patients, coenzyme Q10 for 6 months lowered some oxidative stress markers (protein oxidation products and the oxidized form of CoQ10) and also lowered antioxidant capacity, and the effects reversed after stopping.Coenzyme Q10 administration suppresses both oxidative and antioxidative markers in hemodialysis patients.
- In 30 young adults with type 1 diabetes and kidney complications, adding coenzyme Q10 to standard treatment lowered oxidative damage, improved antioxidant activity and reduced blood sugar markers.Effect of combination therapy with coenzyme Q10 on functional and metabolic parameters in patients with type 1 diabetes …
- In 10 children with trisomy 21 given 10 mg of ubiquinol-10 per kg of body weight daily for 3 months, the blood ratio of active to total coenzyme Q10 rose into the normal range, correcting a pro-oxidant imbalance; there was no placebo group.Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21.
- In 53 healthy men, 150 mg of ubiquinol daily for 14 days significantly lowered a blood enzyme linked to oxidative stress and inflammation, while liver enzyme AST was unaffected.Ubiquinol reduces gamma glutamyltransferase as a marker of oxidative stress in humans.
- In aged rat hearts and human atrial tissue, coenzyme Q10 pretreatment restored recovery of contractile function after stress that was reduced with age.Coenzyme Q10 improves the tolerance of the senescent myocardium to aerobic and ischemic stress: studies in rats and in h…
- Skin cells from older donors showed weaker mitochondrial energy function than those from younger donors, and topically applied coenzyme Q10 improved mitochondrial function in skin.Aging skin is functionally anaerobic: importance of coenzyme Q10 for anti aging skin care.
- In people with Down syndrome, prolonged coenzyme Q10 treatment reduced the share of cells with the highest levels of oxidized DNA bases in an age-specific way, though overall DNA oxidation was not clearly changed.Prolonged coenzyme Q10 treatment in Down syndrome patients: effect on DNA oxidation.
Review Totals and Summary
Members Only1,640 reviews · 93% positive
Across the two stores, Thorne CoQ10 100 mg shows 1563 ratings in total, and the themes below come from the written reviews that could be read on their pages, which amounted to about five individual reviews per store plus one AI-generated overview on Thorne.com. Quality is the most common praise. Reviewers call it a high quality, great product and a top brand for CoQ10, and one says the quality is excellent. The ingredients are described as clean and clinically proven. Several reviewers say it is a Thorne product that is worth its price, though one notes it is slightly more expensive. Brand trust comes up repeatedly: one buyer trusts the company based on its reputation, another calls Thorne a go-to brand, and another says all Thorne supplements are great quality. One reviewer says it is their first bottle from the brand and they were very happy with the purchase. Some say it is exactly as expected. On benefits, the Thorne.com overview says customers praise its effectiveness for energy, heart health and cell health. One reviewer says they seem to have more physical energy, especially after gym workouts, and recover quickly after intense exercise. That person takes it together with acetyl L-carnitine and alpha lipoic acid. A Vitacost review repeats the product description, calling it perfect for daily cellular repair and cardiovascular vitality, boosting energy, supporting heart health and combating aging. One Vitacost reviewer calls it an amazing supplement and says it is perfect for helping with getting pregnant, especially for people over 35. That is a single reviewer's own experience, not something the page establishes. Who it seems to suit: people who want a daily-routine supplement from a trusted brand, gym-goers looking for energy and recovery, and couples; one reviewer and their husband both added it to their daily routine. Another reviewer says it fits well into a daily routine after using it for a while. Complaints are few. The Thorne.com overview notes a recurring complaint that some customers find the capsules and pills too large. In contrast, Vitacost reviewers say the capsules are easy to swallow, so experience with size seems to vary. One Thorne.com reviewer criticises the company website, calling it the worst, and says they will buy in stores instead; this concerns the website, not the supplement. The readable Vitacost reviews contain no complaints about taste, size or effectiveness. Taste is not discussed anywhere, and there is little detail on dosage or long-term results because many reviews are very short, such as "great product" and "Good." On the star ratings, the Vitacost page averages 4.7 stars, with 172 five-star, 28 four-star, 11 three-star, no two-star and 3 one-star ratings. The written Vitacost reviews were all posted by iHerb Customers and labeled as originally posted on iHerb.com, and were dated June 20 to June 28, 2026. No reviews of other forms such as gummies or powder were noted in the summaries, so nothing had to be left out on that count; this account covers the softgels only. Overall the written feedback is positive, centered on quality, brand trust, daily use, and for some an energy boost, with capsule size the one product-related complaint.
Biohacker Summary
Members Only8 of 10 recommend it
Coenzyme Q10 is the main ingredient here, and the panel leans favorable: three of the ten say they take it daily, and several others recommend it, mostly to support the mitochondria, which make energy in cells, and to fight oxidative stress, with some also citing heart health, fatigue, brain health, and sperm quality. Doses people mention run from 100 to 400 mg a day, with 300 mg a common personal dose and a few going higher, and one advises taking it with a fatty meal, ideally dinner. Several point to the ubiquinol form, and one stresses forms that absorb well, while others say to pair it with PQQ or omega-3 or get it from foods like organ meat and fatty fish. A few take it because meds can lower its levels, but one says good data is lacking that it prevents muscle symptoms from meds, another says there is no real evidence it extends lifespan, and one panelist said they stopped taking it while looking for an easier solution.
See all 9 biohackers →Hide the biohackers
Dr. Eric Berg · Coenzyme Q10 · neutral
- Mentions that grass-fed liver has coenzyme Q10.
- Recommends that anyone with a med prescription should also take coenzyme Q10, specifically the ubiquinol form, to support heart and muscle function.
- Notes that Merck filed a patent for a med combined with coenzyme Q10, but never added it back into the formula, and that major heart organizations do not recommend taking coenzyme Q10 alongside meds.
- Recommends taking coenzyme Q10, specifically ubiquinol, to prevent the side effects of meds, especially for those experiencing muscle weakness, pain, fatigue, or exercise intolerance. He suggests a dose of 200 to 400 mg, or even up to 1200 mg a day for some individuals.
- Mentions that coenzyme Q10 supports the heart and mitochondria as a powerful antioxidant, and meds deplete its production.
- States that coenzyme Q10 has been known to help people with fibromyalgia feel better.
- Recommends Coenzyme Q10, especially for those on meds, as it's a key nutrient for energy in the mitochondria and works with vitamin E and selenium, and suggests taking it at lunch with a meal.
- Recommends coenzyme Q10 as a remedy for long COVID.
- Mentions that meds block coenzyme Q10 and refers to another video where he discusses it.
- Dr. Berg highlights coenzyme Q10 as a key essential nutrient for mitochondria in the heart, and recommends taking it if on meds, as meds deplete this nutrient.
Dave Asprey · Coenzyme Q10 · uses
- States he takes 300 mg of Coenzyme Q10 every day for 20 years because it is necessary for mitochondria to function and is important for longevity, noting that meds lower it.
- Recommends coenzyme Q10 (CoQ10) to support mitochondria, as it helps generate energy and fights oxidative stress.
- Mentions that there are methylation genes for Coenzyme Q10 that convert it to ubiquinol.
- Suggests taking Coenzyme Q10 to optimize mitochondria.
- Mentions Coenzyme Q10 as something that can change blood viscosity, alongside sunlight and earthing.
- Includes Coenzyme Q10 as a helpful addition to a med protocol.
- Used to give his dog coenzyme Q10 for mitochondrial function.
- Dave Asprey mentions Coenzyme Q10 as something one might take to boost ATP production.
- Dave Asprey mentions that Coenzyme Q10 is a big deal for a lot of people regarding energy.
- Mentions Coenzyme Q10 as one of the micronutrients that can help protect the glycocalyx.
Andrew Huberman · Coenzyme Q10 · uses
- Personally takes Omega-3 and Coenzyme Q10 every day, noting they are known to support cardiovascular health, cellular health and energy, and brain health.
- Personally takes coenzyme Q10 every day, noting it supports cardiovascular health, cellular health, energy, and brain health.
- Discusses a study where probiotics, magnesium orotate, and coenzyme Q10 showed a short-term improvement in symptoms of major depression.
- Discusses Coenzyme Q10 as a fertility supplement.
- Recommends Coenzyme Q10 at 100 to 400 milligrams per day, taken with a meal containing fat, ideally dinner, to improve sperm quality by supporting mitochondrial health, which is vital for sperm formation and fertilization.
- States that coenzyme Q10 should be taken with food.
- Mentions Coenzyme Q10 as a tool for fertility.
- Andrew Huberman says he personally takes AG1's new Omega-3 Coenzyme Q10 product every day, noting that Omega-3 and Coenzyme Q10 are known to support cardiovascular health, cellular health, energy, and brain health.
- Andrew Huberman notes that some papers suggest coenzyme Q10 might be beneficial for egg quality.
Thomas DeLauer · Coenzyme Q10 · uses
- States that coenzyme Q10 is one of his favorite compounds for the mitochondria, and it is found in sardines.
- Recommends getting coenzyme Q10 from good quality red meat and organ meat, or through supplementation, to act as an electron catcher in the mitochondria, optimizing energy production and reducing oxidative stress.
- Recommends utilizing coenzyme Q10 to support mitochondrial function and the electron transport chain, making hydration more effective.
- Recommends coenzyme Q10 as a runner-up for energy and mitochondrial function, explaining it's an electron carrier in the mitochondrial chain that focuses on the last complex, creating a bigger net to catch electrons and reduce oxidative stress.
- Recommends Coenzyme Q10 for fatigue, stating it's essential for electron transport, ATP regeneration, and reducing oxidative stress, and can be found in organ meats, fatty fish, pistachios, and sesame seeds.
- Mentions Coenzyme Q10 as a micronutrient essential for the complex biological workings of metabolism in the mitochondria.
- Recommends 300-600mg of Coenzyme Q10 for those intermittent fasting or on low carb, to help utilize fuel better, support heart health, and strengthen mitochondrial function by improving the proton gradient.
- Recommends Coenzyme Q10 for people who are fasting or on a ketogenic diet, explaining that it helps fuel the electron transport chain, leading to more efficient energy processing and increased energy during OMAD and the eating period.
- Recommends 300 to 600 milligrams of Coenzyme Q10 during the eating period to help the electron transport chain and utilize food for energy.
- Notes that Coenzyme Q10 is good for mitochondrial health and energy, and there's growing evidence linking it to nitric oxide production, suggesting a supplement if one doesn't get enough from meat.
Dr. Mark Hyman · Coenzyme Q10 · recommends
- Mentions that coenzyme Q10 is important in mitochondrial function and can be a factor in migraines.
- Tried coenzyme Q10 as part of a meticulous effort to address energy and metabolism issues, but implies they no longer use it as they were looking for an easier solution.
- Included coenzyme Q10 in a mitochondrial rejuvenation program to support mitochondrial function.
- States that mitochondria need coenzyme Q10 and that PQQ has been shown to work very well with it.
- States that coenzyme Q10 can be very helpful if fatigue is a significant problem, and is a mitochondrial support for energy recovery.
- Recommends Coenzyme Q10 for better mitochondrial function, lower inflammation, improved insulin sensitivity, and blood sugar, especially for those taking meds or experiencing age-related decline in CoQ10 production.
- Takes Coenzyme Q10, believing it affects the mitochondria and the aging process, even without full scientific confirmation.
- Mentions that coenzyme Q10 was part of the mitochondrial therapy that helped a child with autism improve, and later states it is a key component of mitochondrial supplementation.
- Recommends coenzyme Q10 for mitochondrial repair, stating that high doses of 200 to 400 milligrams a day are needed, spread out with food.
- Recommends Coenzyme Q10 for mitochondrial function, especially for fatigue and heart problems, at doses of 200 to 400 milligrams a day, spread out as 100 milligrams three or four times a day with food, noting its safety and effectiveness for conditions like migraine headaches.
Ben Greenfield · Coenzyme Q10 · neutral
- Discusses Coenzyme Q10 as an ingredient that MitoQ uses in a mitochondria-directed form, noting that standard CoQ10 rarely achieves movement past the cell membrane and into mitochondria.
- Discusses Coenzyme Q10 (CoQ10) in the context of MitoQ Pure being an upgraded form of it.
- Is currently using CoQ10 because any type of a med, including natural ones like red yeast rice extract, can deplete the body's coenzyme Q10 levels, affecting mitochondrial health.
- Is a big proponent of crystal-free coenzyme Q10, explaining that most CoQ10 products have poor absorption due to crystallization, and recommends Pharma Nord's patented process for keeping CoQ10 in solution, which achieves three to ten times higher plasma levels.
- Recommends coenzyme Q10 for lung repair, highlighting its importance for mitochondrial and cardiopulmonary function, especially for those exposed to pollution or who have smoked.
- Takes coenzyme Q10 in the morning for heart disease.
- Is currently using CoQ10 because meds, whether prescription or natural like red yeast rice extract, can strip the body of coenzyme Q10 levels.
- Suggests it is smart to include Coenzyme Q10 for reducing fatigue, referencing a systematic review and meta-analysis.
- Believes Coenzyme Q10 is probably beneficial for 80-year-olds with cardiac issues, but not great for most people, as they are not deficient in it when aging starts around 30-35.
- Recommends a stack of Coenzyme Q10, MitoQ, and PQQ for mitochondrial support, noting that supplements stacking all three are available on Amazon.
Siim Land · Coenzyme Q10 · neutral
- Describes Coenzyme Q10 as a mitochondrial supportive supplement that may increase energy production, but notes there isn't actual lifespan or longevity evidence for it.
- Takes 300 milligrams of Coenzyme Q10 daily as a supplement, noting it helps with energy production, fat oxidization, heart health, and longevity.
Peter Attia · Coenzyme Q10 · neutral
- Notes there isn't good data that Coenzyme Q10 prevents a med Associated muscle symptoms, but doesn't object if patients want to take it because it makes them feel better about taking a med.
Dr. Rhonda Patrick · Coenzyme Q10 · neutral
- A daily dose of coenzyme Q10 reduces blood pressure by about 4mmHg systolic and 3mmHg diastolic in people with type 2 diabetes, potentially lowering cardiovascular risk.
RAL Summary
Members OnlyTier 2 for Healthy Aging
Most human trials of coenzyme Q10 show improvement in aging markers such as oxidative damage, inflammation and skin wrinkles [2][1][4], and 93% of 1650 reviews are positive, which meets tier 2; no trial showed biological age reversal.
Where the evidence disagrees: 4 of the 25 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Cellular energy and mitochondria, Immune system, Skin, Reproductive system, Muscular system
Combine with: CoQ10 supports mitochondrial electron transport and acts as a lipid-soluble antioxidant, which fits cellular aging support. Stack it with PQQ to support mitochondrial biogenesis, and with NAD+ precursors such as nicotinamide riboside or NMN to support cellular energy metabolism and DNA repair enzymes (sirtuins, PARPs). Add alpha-lipoic acid and glutathione or NAC for complementary antioxidant recycling, and magnesium and B vitamins (B2, B3) as cofactors for mitochondrial enzymes. Take with a fat-containing meal for better absorption. Omega-3 fatty acids and vitamin E may further protect membranes from oxidative damage. If you take meds, CoQ10 is particularly helpful, as meds can lower endogenous CoQ10 levels. Check with a clinician if you use meds or meds, since CoQ10 can interact with them.
Possible side effects: No major side effects reported in the studies; some reviewers find the capsules too large to swallow comfortably.
Supplement Facts
Coenzyme Q-10 100 mg
| Calories | 10 | |
| Total Fat | 1 g | |
| Protein | 0.5 g | |
| Coenzyme Q-10 | 100 mg | † |
Other ingredients: Bovine Gelatin, Water, Purified, Glycerin, Lycopene, Turmeric, Conjugated Linoleic Acid, Flaxseed Oil, Soy Monoglycerides.
Directions: Suggested use: Take 1 gelcap one to two times daily or as recommended by your healthcare practitioner.
Barcode (UPC) 693749624011 · Label source: NIH label database · Report a label change
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Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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