Thorne Cytokine Balance Complex Review

Cytokine Balance Complex is a botanical supplement from Thorne, presented as a product that supports a healthy cytokine balance and helps minimise bruising and swelling from minor injury. The product description states that it supports a balanced inflammatory response and recovery after minor injury using ginger, bromelain, Boswellia and curcumin phytosome. The key ingredients listed are Bromelain, Ginger extract (root), Indian Frankincense extract (oleo-gum-resin) and Curcumin Phytosome. Each serving is 2 capsules, and each container provides 30 servings, or 60 capsules. Each serving contains 250mg of bromelain, 250mg of ginger root extract, 250mg of Indian frankincense extract and 250mg of curcumin phytosome. The other ingredients are leucine and a hypromellose capsule derived from cellulose. The product details describe a blend of Ayurvedic herbs, including ginger, Boswellia and curcumin, which together are said to support a healthy cytokine balance in the body. The page also explains that bromelain is a protein-digesting enzyme complex derived from pineapple, and that studies have shown it supports the body's natural response to occasional swelling and bruising from minor injury. The product is described as usable to promote recovery after minor injury. The page states that the product has been third-party tested and certified to verify that what is in the package matches the label and to confirm it contains no unsafe levels of contaminants such as heavy metals, pesticides and microorganisms. The price is listed at $41 for 60 capsules on a one-time purchase, or $36.90 with a subscription that gives 10% off. Subscription options include delivery every 2 weeks, monthly, every 45 days, every 2 months, every 3 months or every 4 months, with free shipping, the ability to pause, skip or cancel at any time, and a further 20% saving when three or more different products are subscribed to. The product is listed as HSA/FSA eligible, with an average saving of 30 percent, and a Truemed payment widget appears on the page though it failed to load. The warnings section states that the product is contraindicated for anyone with a history of hypersensitivity to any of its ingredients. Pregnant women are advised to consult a health-care practitioner before use. Because bromelain has fibrinolytic effects that may inhibit blood clotting, the product should be used with caution or avoided by people on a med therapy. Curcumin has been shown to reduce the efficacy of cyclophosphamide in animal studies and may interfere with the absorption and efficacy of irinotecan, so concurrent use with these agents should be avoided. The page also advises that the powder should not be removed from the capsule to be taken orally, as it can irritate the oral mucosa. The page recommends other Thorne products, including Super EPA Pro, Curcumin Phytosome, CoQ10 and Berberine.

Product Focus: Immune HealthAlso covers:Muscles and jointsBreathingDigestion
Tier ⓘ
Tier 2 · Rank 14
Tier 2 · Researched. Human studies show improvement in an aging-related function or a specific goal, and the reviews agree. Rank 14 within Tier 2 for Immune Health; 16 of 98 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
84 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
84% of 419
Biohacker Mentions
10 of 10
Cost per month
$41

Study, Trial or Testing Result Summary

Members Only58 human studies · 41 improved
58 human studies41 improved6 no effect5,420 people studied

All four ingredients are at or above the doses used in studies. Ginger alone eased hay fever symptoms about as well as a standard allergy drug [1], lowered inflammation markers in people with coronavirus infection [2], and calmed immune cell activity in rheumatoid arthritis [3]. Curcumin reduced days with cold symptoms in healthy adults [4], eased year-round allergy symptoms and shifted immune signals in a healthier direction [5], and lowered inflammation in arthritis [6]. Boswellic acids, given with licorice extract, shortened recovery from coronavirus infection [7], and a boswellia syrup shortened hospital stays [8]. The label gives the frankincense extract amount, not its boswellic acid content, so how it compares to the studied dose is unclear. Bromelain results are mixed and mostly come from enzyme combinations: one combination helped children with sepsis recover from fever sooner [9], but the largest trial found no fewer colds in marathon runners [10]. No study tested this exact product. Animal and cell studies are never counted.

See all 58 studies →Hide the studies

Review Totals and Summary

Members Only419 reviews · 84% positive
419 reviews · Amazon 241 · Google 122 · Thorne 56
84% positive4% neutral12% negative

Across the two store pages the product shows 297 ratings in total, and the themes below come from the written reviews that could be read on those pages, which amounted to five reviews on each page, and they appear to be the same five. The strongest theme is praise for the capsules as an alternative to over-the-counter anti-inflammatories. A reviewer who describes herself as a practitioner says she has taken the product, which she calls Phytoprofen, for over a decade instead of a med. She says it reduces whole body inflammation without the negative effects she associates with a med, and it is now part of her everyday supplement routine. Another reviewer, Sarah C., started it after an allergic reaction to prescribed meloxicam for inflammation. She reports no side effects since starting, says she is highly allergic to many meds, soy, sulfa and other medications, calls it a more natural option and recommends it. One summary notes that her review is cut off with a "read more" link, so the rest could not be read. Tolerability is the second theme. The practitioner reports no gastrointestinal distress even when taking it before bed. Roxana P. calls it an excellent product that is effective and causes no gastric issues. A short review from Lorri V. says only "Works great," with no detail on how it was used or what effects she noticed. On complaints, there is very little in the written text. Laurie H. titled a review "I never ordered this," which points to a possible order or account problem rather than a judgement on the formula, and the review has no usable detail about the product itself. No written review criticises the capsules' effect, taste, form or value, and none mentions price, taste or capsule size. As for who it seems to suit, the feedback points to people who want a non-drug approach to inflammation, those who cannot tolerate conventional anti-inflammatories such as a med or meloxicam, and people with a sensitive stomach or multiple drug allergies. It also appears to suit long-term daily use, given the decade-long experience described. One summary gives the star breakdown for the page with 28 ratings: 20 five-star, one four-star, one three-star, three two-star and three one-star ratings. That suggests strong overall satisfaction alongside a small group of dissatisfied buyers, though the written comments do not explain the lower ratings, so the reasons for those scores remain unknown. Because only five written reviews were readable, the themes above reflect individual experiences rather than a broad consensus. Finally, the page's product name is Cytokine Balance Complex, while the URL and several reviews refer to Phytoprofen, so the reviews may cover the same formula under an older or alternative name. No reviews of other forms such as gummies or powder were identified in the summaries, so nothing had to be left out on that basis.

Biohacker Summary

Members Only10 of 10 recommend it
10 of 10 biohackers on our panel recommend it

The panel is broadly favorable on the two main ingredients, curcumin and ginger, though both come with caveats. For curcumin, most of the panel recommend or use it, mainly to lower inflammation and for joint, brain and mood support, and some pair it with black pepper, omega-3 or sulforaphane because plain curcumin absorbs poorly. Two panelists prefer well-absorbed forms, one a phytosomal form taken daily and another a nanoparticle form, while one advises high-dose curcumin only for specific purposes under a doctor's guidance and another stopped taking it for longevity after finding too little evidence. For ginger, several panelists use or recommend it daily in food or capsules (one gives 3 grams in a vegetable meal) for digestion, nausea, inflammation and blood sugar, but one warns to stop it before surgery because it can thin the blood like a med. Bromelain, a smaller ingredient in this product, was recommended by one panelist for healthy circulation.

See all 10 biohackers →Hide the biohackers
  • Dr. Eric Berg · Ginger · recommends
    • 1 Nov 2026 · recommends · X ↗
      Suggests that ginger is an easy addition to a daily routine that may support digestion, inflammation, and healthy blood sugar levels.
    • 25 Oct 2026 · Curcumin · neutral · Facebook ↗
      Mentions that turmeric contains curcumin, which has been studied for its effects on inflammation, joint discomfort, mood, and blood sugar.
    • 17 Oct 2026 · Curcumin · neutral · Instagram ↗
      Notes that Curcumin barely absorbs without black pepper.
    • 14 Oct 2026 · recommends · YouTube ↗
      Recommends consuming ginger every single day for its benefits on digestion, inflammation, skin, blood sugar stability, and potential fat loss.
    • 2 Oct 2026 · neutral · YouTube ↗
      Mentions ginger as a food that black cumin seed oil outperforms in reducing inflammation.
    • 6 Sep 2026 · Curcumin · recommends · Facebook ↗
      Recommends curcumin, stating it delivers powerful antioxidant and anti-inflammatory effects linked to cardiovascular health and mental well-being.
    • 3 Sep 2026 · Curcumin · neutral · X ↗
      Dr. Eric Berg states that curcumin may support blood sugar, but it should not be treated as an equivalent substitute for other treatments.
    • 2 Sep 2026 · recommends · Facebook ↗
      Lists ginger as an epigenetic factor that may help with cancer prevention.
    • 2 Sep 2026 · Curcumin · recommends · Facebook ↗
      Lists curcumin as an epigenetic factor that may help with cancer prevention.
    • 21 Aug 2026 · Curcumin · neutral · Facebook ↗
      Curcumin is a compound that delivers powerful antioxidant and anti-inflammatory effects.
    • 4 Jul 2026 · Curcumin · recommends · Instagram ↗
      States that curcumin, found in turmeric, delivers powerful antioxidant and anti-inflammatory effects linked to cardiovascular health, mental well-being, and more.
    • 8 Apr 2026 · Curcumin · recommends · YouTube ↗
      Suggests that curcumin can be beneficial to counter some of the effects of a hypoxic state in cancer and inflammation.
    • 28 Jan 2026 · recommends · Podcast ↗
      Recommends ginger as it works to reduce inflammation.
    • 28 Jan 2026 · Curcumin · recommends · Podcast ↗
      States that curcumin, a potent compound in turmeric, can naturally alleviate pain and inflammation, and a study found that 1500 mg of turmeric with black pepper produced results comparable to a med without side effects.
  • Ben Greenfield · Ginger · warns
    • 29 Oct 2026 · warns · YouTube ↗
      Advises patients to stop ginger before surgery because it can act as a med or antiplatelet agent.
    • 13 Jun 2026 · Curcumin · neutral · Facebook ↗
      Mentions curcumin as another Nrf2 activator, but notes that sulforaphane outperforms it.
    • 13 Jun 2026 · Curcumin · uses · YouTube ↗
      States that their curcumin product affects the Nrf2 pathway by activating PKC delta, which phosphorylates Nrf2, allowing it to go into the nucleus, and works synergistically with sulforaphane.
    • 23 May 2026 · recommends · YouTube ↗
      Recommends root spices like ginger for use on the AIP diet.
    • 2 May 2026 · Curcumin · uses · YouTube ↗
      Ben Greenfield's clinic photoactivates curcumin before use, finding it to be very anti-cancer when photoactivated.
    • 26 Mar 2026 · Curcumin · recommends · YouTube ↗
      Says curcumin at low doses, such as sprinkled turmeric onto food, acts as a hormetic stressor, increasing internal defense systems, antioxidants, and repair pathways, leading to overall reductions in inflammation.
    • 20 Nov 2025 · Curcumin · recommends · Facebook ↗
      Recommends MitoQ +Curcumin, a Mitoquinol-enhanced blend with Longvida Curcumin for antioxidant and joint health synergy.
    • 30 Oct 2025 · Curcumin · neutral · Podcast ↗
      Gets nerdy about curcumin and explains which longevity supplements actually work, according to the science in mammals.
    • 30 Oct 2025 · Curcumin · uses · YouTube ↗
      Uses curcumin, taking Keon Flex at night on an empty stomach and a heaping tablespoon of Row Nutrition's liposomal curcumin at some point during the day, but not right after a workout due to its mTor signaling inhibition.
    • 26 Jun 2025 · Curcumin · neutral · YouTube ↗
      Mentions curcumin as a polyphenol that can confer benefits when consumed.
    • 3 May 2025 · Curcumin · recommends · YouTube ↗
      Recommends curcumin to reduce inflammation, especially when combined with the Weber laser treatment.
    • 27 Feb 2025 · Curcumin · recommends · YouTube ↗
      Tells people to take curcumin to block the secondary function of cancer pulling other things like glutamate and converting it through gluconeogenesis.
    • 13 Feb 2025 · recommends · YouTube ↗
      Recommends anti-inflammatory spices like turmeric, ginger, and garlic, often seen in a Mediterranean approach, to help with inflammation and fat loss.
    • 21 Jun 2024 · recommends · YouTube ↗
      He recommends sprinkling ginger into food and rotating it into the diet on a regular basis to induce a hormetic response.
  • Dave Asprey · Curcumin · uses
    • 29 Oct 2026 · uses · YouTube ↗
      Says CallaCurcumin is like "mommy's little helper" and he takes it when he knows he's going to eat late at night, around 5:00 or 6:00, to avoid overeating.
    • 7 Oct 2026 · recommends · YouTube ↗
      Recommends Tetrahydro Curcuminoids, stating they lower inflammation.
    • 7 Oct 2026 · Bromelain · recommends · YouTube ↗
      Recommends Bromelain, stating it supports healthy circulation.
    • 6 Jul 2026 · Ginger · recommends · Instagram ↗
      Recommends ginger as a midwife remedy to help with nausea during pregnancy.
    • 4 Jun 2026 · recommends · YouTube ↗
      Recommends CurcuLite, a curcumin product, for turning up AMPK, which is foundational to energy, longevity, and detox.
    • 5 May 2026 · uses · YouTube ↗
      Takes curcumin, an extract of turmeric, to bypass the oxalate content while still getting the benefits.
    • 6 Nov 2025 · recommends · Podcast ↗
      Dave Asprey mentions that supplements like curcumin support pain relief and mood.
    • 6 Nov 2025 · recommends · YouTube ↗
      Notes that adding curcumins to a med can make it work significantly better, and it is included in their "happy saffron" product. They also recommend a combination of curcumins and omega-3 fatty acids for pain.
    • 16 Oct 2025 · neutral · YouTube ↗
      Notes that turmeric curcumin is also an NRF2 activator, though less bioavailable than sulforaphane.
    • 4 Sep 2025 · recommends · Podcast ↗
      Dave Asprey and his guests reveal how curcumin can rival meds, delivering natural ways to improve metabolism and regulate dopamine.
    • 27 Jun 2025 · Bromelain · neutral · YouTube ↗
      Suggests bromelain as something to experiment with for nightshade sensitivity, though he doesn't have confidence it would fully work.
    • 19 Jun 2025 · Frankincense · recommends · YouTube ↗
      Suggests frankincense as an essential oil choice, noting it doesn't seem to have the downsides that lavender can have.
    • 10 Jun 2025 · Frankincense · neutral · YouTube ↗
      Notes that frankincense essential oil, diffused during religious ceremonies, can alter one's state.
    • 5 Jun 2025 · Frankincense · neutral · YouTube ↗
      Mentions frankincense as an example of a healing plant whose molecular frequency can be copied.
  • Thomas DeLauer · Ginger · neutral
    • 16 Oct 2026 · neutral · YouTube ↗
      Mentions that Dose Daily contains organic ginger root powder.
    • 14 Oct 2026 · Curcumin · recommends · YouTube ↗
      Notes that PET scans showed a significant reduction in amyloid plaque build-up in the group taking curcumin, suggesting fewer instances of Alzheimer's and dementia.
    • 11 Oct 2026 · Curcumin · recommends · YouTube ↗
      Discusses a UCLA study where curcumin led to a 28% increase in cognitive function and a significant reduction in amyloid plaque buildup, suggesting less instance of Alzheimer's and dementia. He also mentions a study where curcumin helped mood as much as a med.
    • 4 Oct 2026 · uses · YouTube ↗
      Uses ginger oil, an ingredient in Curcumin Gold, stating it helps modulate inflammation within the gut.
    • 4 Oct 2026 · Curcumin · uses · YouTube ↗
      Uses Curcumin Gold in their recipe, stating it is amazing because it contains ginger oil, DHA, and curcumin, which work in harmony for the body to operate at its best, helping with inflammation and brain energy.
    • 6 Sep 2026 · Curcumin · neutral · YouTube ↗
      Discusses a UCLA study where participants taking 90 milligrams of curcumin daily for 18 months showed a 28% increase in cognitive function and a significant reduction in amyloid plaque buildup.
    • 1 Sep 2026 · Curcumin · recommends · Instagram ↗
      Recommends Curcumin, stating that 500-1000mg lowers CRP and IL-6 in trials and has over 2000 studies.
    • 16 Aug 2026 · Curcumin · recommends · YouTube ↗
      States that curcumin plus vitamin D is probably the most powerful brain booster and brain protector, explaining that curcumin helps macrophages enlarge to gobble up more amyloid beta.
    • 9 Aug 2026 · recommends · YouTube ↗
      Recommends ginger, explaining that it contains components that allow GLUT4 receptors to disperse more heavily throughout a cell, which helps absorb glucose and reduces blood sugar.
    • 7 Aug 2026 · recommends · YouTube ↗
      Recommends dried ginger powder for insulin resistance, stating that it hits all three pathways simultaneously and significantly lowers fasting blood sugar and reduces insulin resistance.
    • 30 Jul 2026 · recommends · YouTube ↗
      Recommends dried ginger for fat burning, stating that it activates a fat-burning receptor and drives up adrenaline and fat loss without needing caffeine or stimulants. He suggests taking 1 to 5 grams pre-exercise or in a fasted state, or adding it to coffee, electrolytes, or tea.
    • 15 Jul 2026 · recommends · YouTube ↗
      Recommends ginger powder, stating that it hits inflammation from two different angles simultaneously, suppressing enzymes that produce pain and swelling, and suppressing nuclear factor kappa B to block inflammatory gene expression. He suggests using 3g per day consistently for 6 to 8 weeks for muscle soreness reductions.
    • 15 Jul 2026 · Curcumin · recommends · YouTube ↗
      Recommends curcumin, especially when stacked with ginger, noting its anti-inflammatory efficacy and its ability to increase antioxidant defense systems and reduce oxidative stress. He emphasizes taking it with black pepper or piperine, or in a liposomal form, for bioavailability.
    • 14 Jun 2026 · uses · YouTube ↗
      Mentions that Dose Daily, which he recommends for liver support, contains organic ginger root powder.
  • Siim Land · Curcumin · recommends
    • 7 Oct 2026 · recommends · Instagram ↗
      Recommends Curcumin for joint pain and inflammation, based primarily on human research, especially randomized controlled trials showing measurable benefits.
    • 6 Oct 2026 · neutral · X ↗
      Lists Curcumin as one of 15 supplements backed by human studies.
    • 6 Sep 2026 · recommends · Instagram ↗
      Thinks curcumin has some of the strongest evidence and is worth considering.
    • 7 Aug 2026 · neutral · YouTube ↗
      Mentions curcumin as a compound that can increase autophagy, but notes it doesn't come close to exercise in effectiveness.
    • 7 Aug 2026 · Ginger · neutral · YouTube ↗
      Mentions ginger as a compound that can increase autophagy, but notes it doesn't come close to exercise in effectiveness.
    • 7 Jul 2026 · neutral · YouTube ↗
      States that curcumin, unless contaminated, is not going to raise liver enzymes.
    • 12 Jun 2026 · Ginger · recommends · YouTube ↗
      States that ginger lowers body weight in people who are overweight or have high inflammation.
    • 13 May 2026 · Ginger · recommends · YouTube ↗
      Recommends having ginger tea in the evening as it has autophagy-regulating effects.
    • 6 Mar 2026 · neutral · YouTube ↗
      Did not see a big extension from curcumin in their tests.
    • 30 Jan 2026 · neutral · Instagram ↗
      Mentions that it is infeasible to obtain sufficient curcumin from food.
    • 5 Jan 2026 · Ginger · uses · YouTube ↗
      Drinks ginger tea in the evening.
    • 28 Dec 2025 · neutral · YouTube ↗
      Mentions curcumin as a supplement that has been shown to lower CRP and improve metabolic health.
    • 28 Dec 2025 · Ginger · neutral · YouTube ↗
      Places Ginger in the 'good' tier, noting evidence that it helps with weight loss and digestion, though its effects are not very significant.
    • 11 Dec 2025 · recommends · YouTube ↗
      Recommends curcumin for metabolic health, especially for insulin resistance and dyslipidemia.
  • Dr. Mark Hyman · Curcumin · recommends
    • 5 Oct 2026 · recommends · YouTube ↗
      States that curcumin is great for immune support and is anti-inflammatory, suggesting making curries.
    • 5 Oct 2026 · Ginger · uses · YouTube ↗
      Uses ginger in his chicken soup and a special drink because it is anti-inflammatory and helps with symptoms when feeling sick.
    • 14 Sep 2026 · Ginger · recommends · Facebook ↗
      Recommends ginger as an anti-inflammatory powerhouse.
    • 24 Aug 2026 · neutral · YouTube ↗
      Mentions that curcumin has been studied for its anti-inflammatory effects, but emphasizes that no supplement can replace the daily signals created by sleep, nutrition, exercise, stress management, and metabolic health.
    • 27 Jul 2026 · recommends · YouTube ↗
      Recommends curcumin as an anti-inflammatory supplement that can be helpful.
    • 21 Jul 2026 · Ginger · uses · Instagram ↗
      Dr. Mark Hyman designed 'The World's Smartest Smoothie' using organic ingredients, including Organic Ginger juice.
    • 13 Jul 2026 · neutral · YouTube ↗
      States that curcumin helps to lower broader inflammatory levels in the body.
    • 13 Jul 2026 · Bromelain · neutral · YouTube ↗
      Notes that bromelain pairs well with quercetin for absorption.
    • 27 May 2026 · neutral · YouTube ↗
      Explains that curcumin is the key compound in turmeric, a polyphenol that research shows supports the body against conditions like cancer, cardiovascular stress, and neurogenic diseases like dementia, and can also help with inflammation, metabolic balance, joint comfort, and mood.
    • 27 May 2026 · Ginger · neutral · YouTube ↗
      Mentions that Paleovalley's turmeric complex includes organic ginger.
    • 11 Apr 2026 · Ginger · uses · Facebook ↗
      Includes ginger in their smoothie for anti-inflammatory support.
    • 6 Apr 2026 · Bromelain · recommends · YouTube ↗
      Recommends bromelain to reduce inflammation in the nasal passages, which helps with allergy symptoms.
    • 3 Apr 2026 · Ginger · uses · Facebook ↗
      Included ginger in their chicken dish as part of an anti-inflammatory power couple with turmeric.
    • 1 Apr 2026 · Bromelain · recommends · YouTube ↗
      Recommends bromelain, a compound from pineapple, for swelling before and after surgery.
  • Andrew Huberman · Ginger · neutral
    • 28 Sep 2026 · neutral · YouTube ↗
      Discusses a study where people who had taken powdered ginger were less judgmental because their stomachs were calmed, noting that ginger calms the stomach.
    • 10 Jun 2026 · neutral · Facebook ↗
      Asks if ginger can increase metabolism and states that apparently, it can.
    • 8 Jun 2026 · neutral · YouTube ↗
      Conducted a study on ginger powder dissolved in warm water, which significantly elevated the thermic effect of food over a 6-hour period, suggesting it could boost energy expenditure.
    • 13 Apr 2026 · Curcumin · neutral · Podcast ↗
      Discusses curcumin as a supplement for prenatal care and sperm health.
    • 13 Apr 2026 · Curcumin · warns · YouTube ↗
      Does not recommend high-dose curcumin supplements for general use, suggesting it's only for specific purposes under a doctor's guidance to target excess inflammation.
    • 5 Jun 2025 · recommends · YouTube ↗
      States that there are good, unbiased peer-reviewed studies showing that 1 to 3 grams of ginger can cause a notable reduction in nausea.
    • 12 May 2025 · Curcumin · neutral · YouTube ↗
      Notes that people are excited about the possible health benefits of curcumin, which is found in turmeric.
    • 6 May 2024 · Curcumin · uses · YouTube ↗
      Includes curcumin in his diet because it has been shown to stimulate GLP-1.
    • 29 Feb 2024 · Curcumin · warns · YouTube ↗
      Warns against taking high doses of curcumin, noting potential negative effects like limiting dihydrotestosterone production, and advises checking sourcing carefully due to lead contamination concerns.
    • 10 Apr 2023 · Curcumin · neutral · Podcast ↗
      Mentions curcumin in the context of 5-alpha reductase.
    • 10 Apr 2023 · Curcumin · stopped · YouTube ↗
      States he once took curcumin in high dosages (1-2 gram capsules) and felt terrible, vowing never to take it again due to his sensitivity to its effects on the DHT pathway.
    • 22 Feb 2023 · neutral · YouTube ↗
      Mentions ginger as having some potential benefit for inflammation, but notes it's not typically used unless in very specific circumstances like an injury.
    • 22 Feb 2023 · Curcumin · warns · YouTube ↗
      Warns that some people, including himself, are very sensitive to curcumin because it can potently reduce DHT, leading to decreased libido and drive, though these effects reverse quickly after stopping.
    • 6 Feb 2023 · Curcumin · warns · YouTube ↗
      Warns against taking high dosages of curcumin, such as 8000 milligrams per day, because it can alter hormonal pathways, specifically inhibiting dihydrotestosterone (DHT) synthesis, which can lead to undesirable effects like reduced libido.
  • Dr. Rhonda Patrick · Curcumin · neutral
    • 5 Aug 2026 · neutral · Facebook ↗
      Curcumin may be one of the most powerful naturally occurring dietary compounds for lowering age-related inflammation. The phytosomal form is preferred because standard curcumin is rapidly broken down by the liver, while phytosomal delivery makes it far more bioavailable.
    • 5 Aug 2026 · neutral · TikTok ↗
      Asks if curcumin can slow aging.
    • 9 Jul 2026 · Ginger · uses · Instagram ↗
      Likes adding ginger to bone broth for flavor, warmth, and its anti-inflammatory compounds.
    • 24 Jun 2026 · neutral · Facebook ↗
      Curcumin may be one of the most effective natural compounds for lowering age-related inflammation. The phytosomal form matters because standard curcumin is poorly absorbed and rapidly metabolized, while phytosomal delivery makes it much more bioavailable.
    • 22 May 2026 · uses · Facebook ↗
      Takes phytosomal curcumin daily because it is much more bioavailable than standard curcumin and human evidence suggests it is potent for lowering TNF-α, a major inflammatory cytokine linked to biological aging.
    • 15 May 2026 · uses · Instagram ↗
      Rhonda takes 500 mg of liposomal Curcumin daily for inflammation.
    • 30 Apr 2026 · uses · Facebook ↗
      Uses Phytosomal curcumin, stating it is one of the only naturally occurring compounds shown to meaningfully lower TNF-alpha, a master inflammatory cytokine that accelerates aging.
    • 31 Jul 2024 · uses · Instagram ↗
      Took Meriva, a phytosomal curcumin, which has been shown to help with DOMS in some small studies.
    • 12 Jun 2024 · Ginger · uses · YouTube ↗
      Takes a ginger capsule, which seems to improve his digestion.
    • 7 Oct 2021 · recommends · YouTube ↗
      States that curcumin, found in turmeric root, also activates antioxidant defenses.
    • 8 Jun 2021 · recommends · YouTube ↗
      Suggests that if someone is an 'immuno-ager,' they might want to take curcumin to help with their immune system.
    • 5 Apr 2017 · neutral · YouTube ↗
      Rhonda mentions curcumin as a xenohormetic compound that, in a small dose, is slightly toxic and activates cellular stress response pathways, helping the body deal with stress better.
    • Date not recorded · Ginger · uses · Website ↗
      Tim Ferriss consumes ginger with turmeric and black pepper in tea to counteract unnecessary inflammation.
    • Date not recorded · Bromelain · neutral · Website ↗
      A combined anthocyanins and bromelain supplement improves endothelial function and skeletal muscle oxygenation status in adults.
  • Bryan Johnson · Ginger · uses
    • 2 Jul 2024 · uses · YouTube ↗
      Includes three capsules of Ginger in his Blueprint stack.
    • 9 Dec 2023 · uses · YouTube ↗
      Includes 3g of ginger in his Super Veggie for a variety of benefits including liver, pancreas, artery health, and digestion.
    • 27 Jul 2023 · uses · YouTube ↗
      Includes ginger in his Super Veggie meal, which he eats at 7 AM.
    • 25 Jan 2023 · uses · YouTube ↗
      Includes ginger in his daily 'Super Veggie' breakfast for its nutrient density.
    • Date not recorded · uses · Source ↗
      Uses ginger in his Super Veggies.
    • Date not recorded · Curcumin · warns · Website ↗
      Advises avoiding Curcumin during pregnancy.
  • Peter Attia · Curcumin · uses
    • 23 Nov 2020 · uses · YouTube ↗
      Uses a specific nanoparticle version of curcumin at a reasonable dose, which may have anti-TNF alpha effects and help with inflammation.
    • 26 Oct 2020 · recommends · YouTube ↗
      States that a well-absorbed curcumin with high-dose omega-3 is as good as or better than any a med and helps improve brain function, mood, cognition, and may reduce dementia.
    • 31 Dec 2019 · uses · YouTube ↗
      Says that for a 27-year-old woman with an early-onset Alzheimer's gene, they would be "loading her up with curcumin" to prevent symptoms for 25 years.
    • Date not recorded · stopped · Website ↗
      Used to take Curcumin for longevity but stopped because he didn't see enough evidence.
    • Date not recorded · neutral · Website ↗
      Mentions curcumin as another example of a niche compound with numerous RCTs, reinforcing the point that research can be done without pharma sponsorship.

RAL Summary

Members OnlyTier 2 for Immune Health

Controlled human trials of ginger alone show clear immune and inflammation benefits [1][2][3], backed by curcumin and boswellia trials, and 83% of 429 reviews are positive, which meets tier 2. The largest ginger trial cited by the rules used a four-herb blend [11], but the trials of ginger alone still support the tier.

Where the evidence disagrees: 6 of the 58 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Immune system, Musculoskeletal system, Respiratory system, Digestive system

Combine with: For long-term post-meal upper-abdominal comfort, pair with products aimed at digestion directly: a broad-spectrum digestive enzyme with protease, lipase and amylase taken with meals; ginger root or an artichoke leaf extract to support gastric motility and bile flow; and a gentle bitter or peppermint/caraway oil combination for functional dyspepsia. Zinc carnosine or DGL licorice can help support the stomach lining over time. If you do use Cytokine Balance Complex for general inflammatory balance, take it with food and consider adding omega-3 fish oil and vitamin D for broader immune and inflammatory support. Consult a healthcare provider if symptoms are persistent, as they can signal an underlying condition.

Possible side effects: Studies reported few or mild side effects, and readable reviews mention no stomach upset; one study flagged possible interactions of herbal remedies including ginger with HIV medicines.

Supplement Facts

Bromelain 250 mg · Curcumin Phytosome† 250 mg · Ginger extract 250 mg
Supplement Facts
Serving Size Two Capsules
Servings Per Container 30
Amount Per Serving% Daily Value
Bromelain250 mg†
Curcumin Phytosome†250 mg†
Ginger extract (root) (Zingiber officinale)250 mg†
Indian Frankincense extract250 mg†
† Daily Value not established.

Other ingredients: Hypromellose (derived from cellulose) capsule, Leucine.

Directions: Take 2 capsules two to three times daily or as recommended by your health-care practitioner.

Label source: Reverseagelab · Report a label change

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Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.