Thorne Memoractiv Review

Memoractiv is a Thorne nootropic for cognitive function and mental focus, positioned for people who want to maintain a mental edge, support productivity, creativity, and motivation, and help the eyes filter light from blue screens. The product is described as a unique combination of nootropic ingredients, substances that promote creativity and motivation, which also has the potential to support brain health. It contains six botanical extracts and nutrients that the page describes as well studied for cognitive benefits, including support for concentration, motivation, mental focus, and reaction time. The page says the formula is designed for a world filled with deadlines, traffic, and hours of screen time, and states that the ingredients help reduce cortisol levels, fight the effects of stress, and protect the eyes from the negative effects of blue light. Thorne lists who may benefit: millennials and Gen-Xers who want to maintain a mental edge, aging baby boomers who want to maintain mental agility, individuals who spend long hours in front of a computer screen or who experience stress from a tech-driven society, athletes, gamers, and performers who want to support mind-body coordination, overwhelmed students who need creative inspiration and motivation, and anyone looking to unlock their brain's potential. The key ingredients include KSM-66 ashwagandha, described as a root-only full-spectrum extract supported by 22 clinical trials for memory, attention, and stress response; Virtiva ginkgo phytosome, a ginkgo bound to phosphatidylserine for absorption; Lutemax 2020, a marigold extract providing lutein, zeaxanthin, and meso-zeaxanthin; PurEnergy, a co-crystal of pterostilbene and caffeine described as a sustained-release form; acetyl-L-carnitine, an amino acid tied to cellular energy and neurological function; and bacopa extract standardized to 20 percent bacosides. The label lists a serving of 2 capsules, 30 servings per container, and 50 mg caffeine per serving. Suggested use is 2 capsules one to two times daily, taken away from bedtime, or as recommended by a health-care practitioner. Warnings state that the product is contraindicated for people with a history of hypersensitivity to its ingredients, should not be used if pregnant, nursing, or trying to conceive, and should be used with caution or avoided by people on meds or a med therapy or before surgery because of ginkgo. The product is gluten free, dairy free, and capsule based.

Product Focus: Focus and MemoryAlso covers:BrainHormonesDigestionEyes
Tier ⓘ
Tier 2 · Rank 5
Tier 2 · Researched. Human studies show improvement in an aging-related function or a specific goal, and the reviews agree. Rank 5 within Tier 2 for Focus and Memory; 5 of 46 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
86 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
89% of 1,037
Biohacker Mentions
10 of 10
Cost per month
$70

Study, Trial or Testing Result Summary

Members Only149 human studies · 93 improved
149 human studies93 improved20 no effect55,623 people studied

Ashwagandha, the main ingredient, is taken at a full dose. A pooled analysis of 20 trials in 1,249 adults found it improved memory, attention, processing speed and planning skills compared with control [1]. Trials using 600 mg a day for 8 weeks improved memory and attention in adults with memory complaints [2] and in adults with mild memory decline [3]. The ginkgo and phosphatidylserine blend, also at a full dose, improved memory and reaction time in two small, early trials [4][5]. Bacopa at 300 mg a day improved learning and delayed recall in older adults [6][7]. This product gives about 200 mg a day, and a large pooled analysis found the clearest memory gains at 600 mg or more [8]. Lutein with zeaxanthin improved attention in some trials [9], but a five-year trial in older adults found no slowing of mental decline [10]. Acetyl-L-carnitine is below the 1.5 grams a day that helped older adults with mild decline [11], and it did not slow established Alzheimer's disease [12]. The energy ingredient, a pterostilbene and caffeine blend, has no human studies here. Animal and cell studies are never counted.

See all 149 studies →Hide the studies

Review Totals and Summary

Members Only1,037 reviews · 89% positive
1,037 reviews · Amazon 647 · Google 254 · Thorne 82 · Walmart 54
89% positive5% neutral6% negative

Buyers mostly like Thorne Memoractiv capsules, and most describe a noticeable lift in focus or memory. Price is the most common complaint. It carries about 783 ratings across the stores, and most reviews with stars give 4 or 5. **What buyers say it did for them:** Focus and clarity come up most. One buyer says it left them "calm, collected, and focused" at the start of the day, and another calls it a "great way to get focused on those busy days." A woman dealing with post-menopausal fogginess says it took about a week to notice a change and that she then cut down to one pill to avoid feeling jittery. Another says that after a few months they enjoyed "remembering names and details that used to slip away." One buyer says it pairs well with their ADHD medication. Store summaries also describe a gradual effect, a "clean" boost without jitters, use during exam season, and some reports of mood improvement and cleared brain fog. One store page mentions a single reviewer who reported more energy. Plenty of reviews are only short praise, such as "Love it and it really helps and works." **What they complain about:** Not everyone noticed an effect. One 2-star reviewer wrote "Didn't notice anything" despite finishing the whole bottle. One store's summary mentions some customers with no benefit and others with stomach issues. One store page also had a "never received" comment, which is a delivery problem and not about the supplement. **Taste, smell, pill size and form:** Capsule size gets mixed comments. One buyer says the capsule is "too big for me" and opens it to mix the contents into water. Another store's summary says the capsules are easy to swallow. Nothing in the reviews describes taste or smell. **Value for money:** Price is the main sore point. One loyal buyer says "Love the product. Hate the price," and warns that cheaper products from good brands exist, though they plan to keep buying. One store's summary also calls it pricey and lists value for money as a negative theme. **Who it seems to suit and who it did not:** It seems to suit people who want help with focus, memory or mental fog, including those with busy or demanding days, such as public speaking, tactical training, study or work periods. Some say they trust the Thorne brand and like the mix of ashwagandha, L-carnitine and ginkgo. It suited some people less well: those who felt no effect, those sensitive to stomach upset or jitteriness (one reviewer needed to lower the dose), those who struggle with large capsules, and those who are very price-conscious. Reviews of other forms of this product were left out, and this summary covers the capsules only.

Biohacker Summary

Members Only10 of 10 recommend it
10 of 10 biohackers on our panel recommend it

Ashwagandha, the main ingredient, gets a mostly positive but cautious response: six of the ten panelists recommend it, one uses it daily, and three are neutral, though one of those called the data weak. People take it mainly to lower stress and cortisol, sleep better, and in some cases support testosterone, with doses mentioned of 250 mg, 400 to 600 mg, and a range of 120 to 1,000 mg for at least six weeks, and several prefer standardized extracts or take it at night. Cautions are common: panelists advise cycling it, including a two-week break after two weeks of use, and warn of emotional numbing, feeling weird, irritability in women, and a poor fit for people with low cortisol, and one person stopped because it caused a mouth sore. L-carnitine is a smaller ingredient in this product, and the few panelists who mentioned it recommended it mainly for fertility and energy production in cells.

See all 10 biohackers →Hide the biohackers
  • Dr. Mark Hyman · Ashwagandha · recommends
    • 23 Oct 2026 · recommends · Facebook ↗
      Lists ashwagandha as an herb that can help lower anxiety or depression symptoms.
    • 11 Mar 2026 · neutral · YouTube ↗
      Notes that there was a recent study on ashwagandha for sperm health, indicating it's an evolving area of research.
    • 25 Jun 2025 · L-Carnitine · neutral · YouTube ↗
      Mentions that supplementing with L-carnitine can make mitochondria more efficient.
    • 5 Feb 2025 · recommends · YouTube ↗
      Suggests trying ashwagandha, noting that some people respond to it, and recommends a dose of 400 to 600 mg.
    • 15 Nov 2024 · recommends · YouTube ↗
      Recommends adaptogenic herbs like ashwagandha, particularly at night, rhodiola, lemon balm, and catclaw for stress relief.
    • 1 Nov 2024 · recommends · YouTube ↗
      Recommends ashwagandha at night as an adaptogen to help with high cortisol and promote sleep for those who are tired and wired.
    • 25 Sep 2024 · recommends · YouTube ↗
      Recommends ashwagandha, stating it can help convert T4 to T3, but advises ensuring a clear source and monitoring liver enzymes.
    • 23 Aug 2024 · L-Carnitine · recommends · YouTube ↗
      Recommends Acetyl L-Carnitine as it is critical in fat metabolism and supports the transport of fatty acids into the mitochondria for energy.
    • 26 Jul 2024 · recommends · YouTube ↗
      Suggests adaptogens like rhodiola, ashwagandha, ginseng, and Siberian ginseng can be helpful for actively managing stress.
    • 12 Jun 2024 · uses · YouTube ↗
      States that Mosh protein bars contain ashwagandha to support a healthy brain.
    • 1 Mar 2024 · recommends · YouTube ↗
      Recommends adaptogens like Ashwagandha if one has a lot of stress.
    • 28 Feb 2024 · L-Carnitine · recommends · YouTube ↗
      Recommends L-carnitine as critical for producing sperm and increasing antioxidant status in men.
    • 21 Feb 2024 · recommends · YouTube ↗
      States that ashwagandha can stimulate osteoblasts, which helps with bone building, especially for those with a genetic predisposition to low bone density.
    • 29 Sep 2023 · L-Carnitine · recommends · YouTube ↗
      States that making energy in mitochondria requires carnitine and recommends acetylol carnitine or L-Carnitine at 500 to 2000 milligrams a day, usually 500 once or twice a day, as it is important in metabolizing fats.
  • Dr. Eric Berg · Ashwagandha · recommends
    • 8 Oct 2026 · recommends · YouTube ↗
      Recommends ashwagandha, suggesting 250 milligrams per day over time to increase stress tolerance and help the cortisol receptor.
    • 4 Sep 2026 · neutral · X ↗
      Rates Ashwagandha on a scale from 1 to 10.
    • 26 Jun 2026 · recommends · YouTube ↗
      Lists ashwagandha as one of the best ways to lower luteinizing hormone, which goes too high as people age and is related to dementia.
    • 5 May 2026 · neutral · YouTube ↗
      Notes that some people take ashwagandha or other adaptogens to help calm them down when they assume their problem is cortisol, and sometimes it works.
    • 27 Apr 2026 · recommends · YouTube ↗
      States that taking ashwagandha on a regular basis can greatly help the adrenals.
    • 12 Jan 2026 · recommends · Podcast ↗
      Recommends Ashwagandha to help make the process of quitting coffee smoother.
    • 8 Jan 2026 · recommends · YouTube ↗
      Recommends taking adaptogens like ashwagandha for super powerful and real energy inputs without artificial side effects.
    • 25 Sep 2025 · recommends · Podcast ↗
      Recommends Ashwagandha to help sleep through the night.
    • 20 Sep 2025 · recommends · YouTube ↗
      Recommends taking Ashwagandha in the evening before bed as a remedy for problems with elevated cortisol around 2 AM, when cortisol should be at its lowest point.
    • 16 May 2025 · recommends · Podcast ↗
      Recommends trying ashwagandha to lower stress levels.
    • 31 May 2024 · L-Carnitine · neutral · YouTube ↗
      Mentions L-carnitine as another nutrient that can be depleted, similar to co-enzyme Q10.
    • 24 Feb 2024 · L-Carnitine · recommends · YouTube ↗
      Explains that L-Carnitine helps burn fat during exercise, preserves muscle protein, and aids in recovery from exercise, noting it is very high in red meat.
    • 18 Mar 2020 · L-Carnitine · recommends · Podcast ↗
      States that the best way to use L-Carnitine is for cardiovascular health, as the heart needs it to transport fatty acids for energy.
    • 6 Oct 2019 · L-Carnitine · recommends · YouTube ↗
      Recommends L-carnitine for people with congestive heart failure, arrhythmia, or any type of heart damage, stating it is dynamite for the heart.
  • Siim Land · Ashwagandha · recommends
    • 7 Oct 2026 · recommends · Instagram ↗
      Recommends Ashwagandha for stress, sleep and performance, based primarily on human research, especially randomized controlled trials showing measurable benefits.
    • 6 Oct 2026 · neutral · X ↗
      Lists Ashwagandha as one of 15 supplements backed by human studies.
    • 6 Sep 2026 · neutral · X ↗
      Notes that Ashwagandha is one of several supplements with human evidence.
    • 7 Jul 2026 · neutral · YouTube ↗
      States that ashwagandha, unless contaminated, is not going to raise liver enzymes.
    • 4 Jul 2026 · stopped · YouTube ↗
      Stopped taking ashwagandha because it immediately caused a mouth sore.
    • 12 Jun 2026 · recommends · YouTube ↗
      States that ashwagandha consistently reduces stress and anxiety in randomized controlled trials.
    • 5 Jun 2026 · neutral · Instagram ↗
      States that Ashwagandha helps with testosterone primarily in stressed out or poor sleeping people.
    • 30 Mar 2026 · recommends · YouTube ↗
      States that ashwagandha has strong evidence for increasing testosterone, mostly in stressed or infertile men.
    • 5 Jan 2026 · warns · YouTube ↗
      Mentions ashwagandha as an example of a testosterone-boosting supplement he has no interest in taking.
    • 28 Dec 2025 · recommends · YouTube ↗
      Places Ashwagandha, specifically the KSM66 form, in the 'god tier' due to extensive research supporting its benefits for stress, sleep, testosterone production, estrogen, and even V2 max, while personally not experiencing any negative side effects some people report.
    • 17 May 2024 · Bacopa · neutral · YouTube ↗
      Notes that bacopa helps with cognition.
    • 12 Apr 2023 · L-Carnitine · stopped · YouTube ↗
      Stopped taking L-Carnitine because it converts to TMAO, a cardiovascular disease risk factor, and he hasn't noticed significant benefits for muscle growth or fat oxidation, preferring not to gamble with the risk given his family history of cardiovascular disease.
    • 5 Dec 2022 · L-Carnitine · uses · YouTube ↗
      States that L-Carnitine is great and can help with androgen receptor density for muscle growth, and he takes it before resistance training for this purpose, but not daily.
    • 16 Jun 2021 · L-Carnitine · uses · YouTube ↗
      Experimented with acetyl-L-carnitine to improve his performance on the soccer field, specifically his ability to read the play.
  • Thomas DeLauer · Ashwagandha · recommends
    • 3 Oct 2026 · recommends · YouTube ↗
      Recommends ashwagandha extract, noting a study where 57 overweight men over 40 saw a 14.7% increase in testosterone and an 18% increase in DHEA over 16 weeks, suggesting it removes the cortisol block suppressing the entire hormonal cascade.
    • 2 Sep 2026 · recommends · YouTube ↗
      Mentions ashwagandha as part of a full testosterone protocol, supporting production through different pathways.
    • 14 Mar 2026 · recommends · Facebook ↗
      Recommends ashwagandha, noting it modulates the HPA axis and dropped cortisol by approximately 23% in 60 days, but advises cycling it, especially if feeling emotionally numb.
    • 14 Jan 2026 · warns · YouTube ↗
      Cautions against Ashwagandha due to its potential for emotional numbing effects.
    • 17 Sep 2025 · recommends · YouTube ↗
      Suggests ashwagandha at night to help regulate cortisol, but advises playing around with it as some people find it makes them feel weird.
    • 23 Aug 2025 · recommends · YouTube ↗
      Recommends Ashwagandha, Rhodiola, and Ginseng as adaptogens to help the body adapt to stress, bring cortisol levels back to homeostasis, and support heat shock proteins and stress chaperoning pathways, especially when in a caloric deficit.
    • 6 Jun 2025 · L-Carnitine · recommends · YouTube ↗
      Recommends L-carnitine, especially if working out, to help shuttle fat into the cell better and improve fat oxidation, particularly in a fasted state before a workout.
    • 26 May 2025 · recommends · YouTube ↗
      Recommends Ashwagandha in the evening time for its anti-cortisol effect, helping to regulate cortisol for better balance in the morning.
    • 5 Apr 2025 · recommends · YouTube ↗
      Recommends ashwagandha as an adaptogen with a profound effect on cortisol, acknowledging that it can make some people feel numb but may still be helpful.
    • 28 Mar 2025 · neutral · YouTube ↗
      Discusses Ashwagandha as an adaptogen with quite a bit of evidence for various benefits like cognitive ability, stress, stamina, cardiovascular benefits, and lipid panels. He notes that long-term use might lead to a level of tolerance or an apathetic sense, suggesting it should be used when sincerely needed.
    • 18 Mar 2025 · L-Carnitine · uses · YouTube ↗
      Takes L-carnitine.
    • 23 Jan 2025 · recommends · YouTube ↗
      Recommends Ashwagandha to help regulate oxidative stress.
    • 17 Dec 2024 · L-Carnitine · uses · YouTube ↗
      Takes supplements like Acetyl-L-Carnitine to enhance mitochondrial function.
    • 2 Dec 2024 · L-Carnitine · recommends · YouTube ↗
      Discusses the mixed opinions on L-Carnitine for fat loss but concludes that it is beneficial, citing a meta-analysis showing an average of 1.33 kg of fat lost. He suggests that many people may be more deficient than they think, especially those who exercise intensely, and that it is an inexpensive supplement worth trying.
  • Ben Greenfield · Ashwagandha · neutral
    • 23 Sep 2026 · neutral · X ↗
      Ashwagandha, taken as 120–1,000 mg for at least 6 weeks, with most studies providing a dose of 400–600 mg/d, can lower cortisol levels, improve sleep quality, and enhance cognitive resilience for athletes during challenging phases consisting of high-volume resistance training.
    • 19 Sep 2026 · L-Carnitine · recommends · YouTube ↗
      Recommends L-carnitine for male fertility, explaining that it helps shuttle fatty acids into mitochondria, assisting with beta-oxidation, and its concentration in sperm correlates with sperm motility.
    • 19 Sep 2026 · L-Carnitine · neutral · Podcast ↗
      He mentions L-carnitine as a supplement with real human data behind it for male fertility.
    • 8 Sep 2026 · L-Carnitine · recommends · X ↗
      Recommends L-carnitine at 1-3 grams per day for at least 30 days pre-conception to improve mitochondrial function tied to sperm quality.
    • 30 Jun 2026 · neutral · Instagram ↗
      Notes that ashwagandha is an ingredient in MTE.
    • 5 Jun 2026 · neutral · TikTok ↗
      Mentions Ashwagandha as a supplement people cycle through when still sleeping poorly, suggesting it might not be addressing the true sleep problem.
    • 23 May 2026 · neutral · YouTube ↗
      Notes that ashwagandha is a nightshade herb, but it is taken as a supplement and not used for cooking.
    • 23 Dec 2025 · recommends · Facebook ↗
      States that Ashwagandha helps regulate stress response and steady the nervous system, influencing biological systems tied to sleep quality.
    • 11 Dec 2025 · uses · YouTube ↗
      Has found that adaptogens like ashwagandha, taken about half an hour before using the Shift Wave, seem to enhance its effects on tuning up the nervous system. He also found it helped him and his co-founder achieve slower respiratory heart rate coherence.
    • 20 Nov 2025 · L-Carnitine · recommends · Facebook ↗
      Recommends MitoQ +Heart, a Mitoquinol-enhanced blend with L-Carnitine, Magnesium, and Vitamin D3 for cardiovascular and energy support.
    • 13 Nov 2025 · L-Carnitine · recommends · YouTube ↗
      States that acetyl L-carnitine is very important as a transport molecule that facilitates the entry of fatty acids into the mitochondrial chain, which can produce 100 ATP per molecule.
    • 24 Oct 2025 · Bacopa · uses · Facebook ↗
      Uses Bacopa as part of the Neuro Regenerate product to boost BDNF production, improve blood flow, and sharpen mental clarity.
    • 1 Oct 2025 · uses · Facebook ↗
      Uses Ashwagandha, as part of IM8 Health, to quiet the stress response for sleep.
    • 6 Sep 2025 · neutral · YouTube ↗
      Mentions ashwagandha as an herb that has more data than fruit tree leaves.
  • Dave Asprey · Ashwagandha · neutral
    • 29 Aug 2026 · neutral · YouTube ↗
      Dave Asprey notes that ashwagandha, when taken as a real standardized extract at a real dose, genuinely lowers cortisol and shows effects on stress and sleep quality in randomized trials, but lacks polysomnography data.
    • 25 Jun 2026 · neutral · Podcast ↗
      Dave Asprey discusses ashwagandha as part of an adaptogen trio that works together for stress response and human performance.
    • 25 Jun 2026 · neutral · YouTube ↗
      Mentions ashwagandha as an adaptogen in MTE that helps blunt the cortisol spike.
    • 27 May 2026 · warns · YouTube ↗
      Advises against ashwagandha for low cortisol, stating that salt and water are needed instead.
    • 9 Apr 2026 · warns · YouTube ↗
      Warns that ashwagandha can raise testosterone in women, causing irritability, and therefore needs to be cycled.
    • 19 Mar 2026 · neutral · Podcast ↗
      Dave Asprey mentions ashwagandha as a supplement and cofactor that supports thyroid activation.
    • 19 Mar 2026 · recommends · YouTube ↗
      Recommends ashwagandha as a cofactor that can help thyroid function, especially with conversion issues.
    • 12 Mar 2026 · neutral · Podcast ↗
      Dave Asprey lists ashwagandha as part of a supplement stack that supports healthy hormone levels.
    • 16 Dec 2025 · L-Carnitine · recommends · YouTube ↗
      States that L-Carnitine shows changes happening in fertility.
    • 10 Oct 2025 · L-Carnitine · neutral · YouTube ↗
      Mentions that Acetyl-L-Carnitine is usually a good mitochondrial enhancer, but not everyone needs it.
    • 28 Aug 2025 · neutral · YouTube ↗
      Discusses ashwagandha as a common adaptogenic herb used by biohackers to deal with stress, noting it was banned in Denmark and can cause anhidonia and reduced ability to reach orgasm at higher doses.
    • 5 Aug 2025 · warns · Podcast ↗
      The episode discusses the dangers of chronic ashwagandha use.
    • 5 Aug 2025 · L-Carnitine · uses · YouTube ↗
      Uses Acetyl-L-Carnitine on a regular basis as a well-known enhancer of mitochondrial fatty acid oxidation.
    • 27 Jun 2025 · L-Carnitine · uses · YouTube ↗
      Has included L-carnitine or acetyl-L-carnitine in his cognitive enhancement and longevity stack since his mid-20s, and finds its use for joints to be innovative.
  • Peter Attia · Ashwagandha · neutral
    • 1 Jun 2026 · neutral · Podcast ↗
      Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
    • 30 Oct 2025 · uses · YouTube ↗
      Finds ashwagandha a little bit helpful for sleep, though notes it may not be for everyone.
    • 27 Oct 2025 · neutral · YouTube ↗
      Finds ashwagandha "a little bit helpful" for sleep, but notes that it may not be for everyone.
    • 30 Mar 2025 · neutral · YouTube ↗
      Finds ashwagandha a little bit helpful for sleep, but notes it may not be for everyone.
    • 23 Mar 2025 · warns · YouTube ↗
      States that the data for ashwagandha are weak.
    • 17 Mar 2025 · neutral · Instagram ↗
      Discusses the current evidence for ashwagandha's effects on sleep, stress, and anxiety.
    • 16 Mar 2025 · neutral · YouTube ↗
      Mentions ashwagandha as an evergreen shrub historically used in traditional Indian medicine for indications such as sleep, stress, and immune health.
    • 3 Mar 2024 · L-Carnitine · warns · YouTube ↗
      Discusses L-carnitine, noting that people inject it for fat loss and to get more out of testosterone input, but warns against injecting it due to potential contamination from homebrewing or even compounding pharmacies, which have had issues leading to deaths.
    • 26 Feb 2024 · neutral · YouTube ↗
      Mentions ashwagandha as something that can help with sleep in the setting of chronic stress and hypercortisolemia.
    • 26 Feb 2024 · L-Carnitine · warns · YouTube ↗
      Warns that injecting L-carnitine, especially if home-brewed, is a bad idea due to sterilization concerns and potential for contamination, which can lead to serious health issues.
    • 26 Feb 2024 · L-Carnitine · neutral · Podcast ↗
      Derek explores L-carnitine as a fat loss supplement.
    • 24 Oct 2023 · uses · YouTube ↗
      Takes 600 mg of Solgar ashwagandha at night, having recently switched to this brand and returned to taking it after a previous hiatus.
    • 23 Oct 2023 · uses · YouTube ↗
      Takes 600 milligrams of ashwagandha at night, having recently switched to the Solgar brand and having returned to taking it after a long break.
  • Andrew Huberman · Ashwagandha · recommends
    • 14 May 2026 · recommends · Podcast ↗
      He shares science-based tools for modulating aggression, including supplementation with ashwagandha.
    • 27 Jul 2026 · L-Carnitine · recommends · YouTube ↗
      Andrew Huberman, based on discussions with fertility doctors, recommends L-carnitine for patients trying to increase fertility, egg quality, or sperm quality, noting it can be taken orally in higher dosages like 500 or 750 milligrams a day, or via injectable form.
    • 14 May 2026 · warns · YouTube ↗
      Warns that while ashwagandha is a potent inhibitor of cortisol, chronic supplementation for longer than two weeks can disrupt other hormone and neurotransmitter pathways, so it should be used with a two-week break after two weeks of use.
    • 14 May 2026 · L-Carnitine · recommends · Podcast ↗
      He shares science-based tools for modulating aggression, including supplementation with acetyl-L-carnitine.
    • 14 May 2026 · L-Carnitine · neutral · YouTube ↗
      Discusses a study showing that acetyl-L-carnitine supplementation significantly improved symptoms of ADHD, including reductions in aggressive behavior, attentional problems, and delinquency.
    • 13 Apr 2026 · L-Carnitine · recommends · YouTube ↗
      Recommends L-carnitine for sperm health.
    • 23 Mar 2026 · L-Carnitine · uses · YouTube ↗
      Has started experimenting with L-carnitine in an injectable form, taking a much lower milligram count than oral doses, to avoid absorption issues and concerns about increased TMAO from oral intake. They acknowledge its benefits for mitochondrial health.
    • 4 Aug 2025 · recommends · Podcast ↗
      Recommends Ashwagandha as a supplement to reduce cortisol.
    • 19 Jun 2025 · L-Carnitine · neutral · Podcast ↗
      Mentions Acetyl-L-carnitine in the context of whole body pain.
    • 13 Mar 2025 · recommends · Podcast ↗
      Explains how to optimize hormone levels through supplements such as ashwagandha.
    • 13 Mar 2025 · recommends · YouTube ↗
      Mentions ashwagandha as a potent commercial compound in supplement form that can be used to reduce chronic stress, especially late in the day, by significantly decreasing cortisol.
    • 16 Jan 2025 · neutral · Podcast ↗
      Discusses Ashwagandha as a supplement to better manage stress.
    • 16 Jan 2025 · uses · YouTube ↗
      Uses ashwagandha when feeling particularly stressful to lower anxiety and cortisol, but does not take it year-round or on a regular basis.
    • 29 Jul 2024 · uses · YouTube ↗
      Takes ashwagandha for sleep.
  • Dr. Rhonda Patrick · Ashwagandha · recommends
    • 13 Sep 2025 · recommends · Facebook ↗
      Recommends Ashwagandha supplementation, specifically standardized for withanolides (KSM-66 at 5% or Sensoril at 10%), to indirectly boost testosterone by reducing cortisol levels, and also to improve anxiety, stress resilience, and sleep quality.
    • 7 Sep 2026 · L-Carnitine · neutral · YouTube ↗
      Discusses L-carnitine's role as a transporter for fatty acids into mitochondria for energy, its role in detoxifying metabolites, and its involvement in stabilizing cell membranes and ketone production. They mention studies showing it helps increase muscle mass and improve cognitive function in women, and meta-analyses showing reductions in body weight, waist size, and body fat in overweight and obese individuals.
    • 9 Sep 2025 · warns · YouTube ↗
      Recommends ashwagandha, specifically patented extracts like Sensoril or KSM66 standardized to sufficient quantities of withanolides, for its indirect effect on testosterone by suppressing cortisol and stress response, which can be beneficial for anxious individuals and improve sleep.
    • 27 Aug 2024 · recommends · YouTube ↗
      Is very bullish on Ashwagandha, citing meta-analyses showing improved lean mass, strength, sleep, and stress management. He notes it also raises testosterone but not enough to explain the lean mass changes.
    • 22 Aug 2024 · neutral · Podcast ↗
      Discusses ashwagandha.
    • 27 Dec 2023 · uses · YouTube ↗
      Uses ashwagandha as a supplement to help with sleep.
    • 28 Apr 2022 · L-Carnitine · uses · YouTube ↗
      Takes acetyl-L-carnitine in the morning, believing it is beneficial with the ketogenic diet and can help boost ketosis, as people on a ketogenic diet can be deficient in carnitine.
    • Date not recorded · neutral · Website ↗
      Dr. Rhonda Patrick discusses curcumin & ashwagandha safety.
    • Date not recorded · uses · Website ↗
      His regular sleep supplements are glycine, ashwagandha, magnesium L-threonate, and magnesium oxide.
    • Date not recorded · neutral · Website ↗
      She mentions that Peter Attia takes 600 milligrams of ashwagandha from Solgar.
    • Date not recorded · L-Carnitine · neutral · Website ↗
      L-carnitine is important for transporting fatty acids into the mitochondria for energy and plays a role in detoxifying potentially toxic metabolites. Supplementation in the range of 1 to 4 g a day along with carbohydrates has shown benefits in muscle mass, cognitive function, and reductions in body weight and waist size in overweight and/or obese individuals.
    • Date not recorded · L-Carnitine · neutral · Website ↗
      She thinks it would be useful to add acetyl-L-carnitine to her alpha-lipoic acid for mitochondrial benefits, but it's not high on her list because she eats a lot of meat, which is high in carnitine.
    • Date not recorded · L-Carnitine · neutral · Website ↗
      Dr. Rhonda Patrick reviews how L-carnitine affects mitochondrial energy metabolism.
  • Bryan Johnson · Ashwagandha · uses
    • 8 Jul 2025 · uses · YouTube ↗
      Drinks his Blueprint longevity mix with additional morning supplements, including ashwagandha.
    • 5 Jun 2025 · uses · YouTube ↗
      States that Blueprint Ashwagandha can be used to stabilize mood.
    • 20 Feb 2024 · uses · YouTube ↗
      Mentions that Ashwagandha is included in the LA Longevity Mix, which condenses his 100 daily pills into a drink.
    • 7 Dec 2023 · neutral · Instagram ↗
      Mentions ashwagandha as a potential therapy that could positively influence sperm health.
    • 27 Jul 2023 · uses · YouTube ↗
      Mentions ashwagandha as an ingredient in his 'bag of goodies', indicating he uses it.
    • 21 Jun 2023 · uses · YouTube ↗
      Takes ashwagandha for anti-anxiety, improved cortisol management, improved sleep, and increased testosterone.
    • Date not recorded · uses · Website ↗
      Uses Ashwagandha + Rhodiola for energy and stress support.
    • Date not recorded · warns · Website ↗
      Recommends Ashwagandha during the luteal phase to help reduce stress, balance hormones, reduce PMS related fatigue, and combat water retention and bloating, and also for stress and mood management in perimenopausal and menopausal women.
    • Date not recorded · uses · Website ↗
      Lists "Ashwagandha + Rhodiola" with "120mg" as part of his supplements, implying its use.
    • Date not recorded · recommends · Source ↗
      During menopause, Bryan Johnson recommends adding ashwagandha based on individual needs.

RAL Summary

Members OnlyTier 2 for Focus and Memory

Ashwagandha at a full dose improved memory and attention in a pooled analysis of 20 trials [1], and 89% of 1,047 reviews are positive, which meets tier 2.

Where the evidence disagrees: 20 of the 149 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Nervous system, Endocrine system, Digestive system, Eyes

Combine with: For cognitive support, Memoractiv pairs well with omega-3 fatty acids (DHA/EPA) for neuronal membrane health, bacopa monnieri for memory acquisition, and citicoline or alpha-GPC as additional choline sources. B-complex vitamins (methylated B12, folate, B6) support homocysteine metabolism and brain function, and magnesium L-threonate may add synaptic support. Lion's mane mushroom and ginkgo biloba are also commonly stacked for mental clarity. If weight management is the real goal, consider a separate protocol with protein, fiber such as glucomannan, green tea extract, berberine, or chromium, along with resistance training and a calorie-controlled diet, and consult a healthcare provider first.

Possible side effects: Bacopa caused loose stools, cramps and nausea in a trial, and some buyers report stomach upset. One buyer felt jittery and lowered the dose; the product contains caffeine.

Supplement Facts

KSM-66 300 mg · Acetyl-L-Carnitine 250 mg · Virtiva 240 mg
Supplement Facts
Serving Size 2 Capsule(s)
Servings Per Container 30
Amount Per Serving% Daily Value
KSM-66300 mg†
Acetyl-L-Carnitine250 mg†
Virtiva240 mg†
PURENERGY116 mg†
Bacopa leaf extract100 mg†
Lutemax 202010 mg†
Lutemax 20202 mg†
† Daily Value not established.

Other ingredients: Hypromellose, Calcium Laurate.

Directions: Suggested Use: Take 2 capsules one to two times daily away from bedtime or as recommended by your health-care practitioner.

Barcode (UPC) 693749737025 · Label source: NIH label database · Report a label change

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Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.