Thorne Super EPA 425 mg Review
Super EPA is a Thorne omega-3 fish oil supplement that provides two essential omega-3 fatty acids, EPA and DHA. According to the page, it is designed to support a healthy heart and brain, help maintain a healthy inflammatory response in the muscles and joints, and promote healthy skin. The product is listed as NSF Certified for Sport and is sold as 90 gelcaps per container, with a serving size of one gelcap. Each softgel contains 425 mg of EPA and 270 mg of DHA. The page describes Super EPA as containing EPA and DHA, two omega-3 fatty acids important throughout adulthood, as well as during periods of increased brain growth that characterize prenatal and postnatal development. Thorne states that the product uses the highest quality, purest fish oil available from sustainably sourced cold-water fish. The listed benefits include support for the health of blood vessels and optimal blood flow, help maintaining healthy triglyceride levels, a healthy inflammatory response in joints, muscles, and throughout the body, immune function modulation, nutritional support for healthy fetal brain development, support for a positive mood, cognitive and brain health, healthy skin, and weight management through a healthy insulin response. Features include a best-selling Thorne formula for more than three decades, an optimal balance of EPA and DHA, sustainable fish harvesting practices, molecular distillation that removes contaminants including PCBs and heavy metals, and an ethyl ester molecular form that provides more concentrated EPA and DHA with fewer capsules. The page explains that every batch of an NSF Certified for Sport product is tested for compliance with label claims and for the absence of nearly 300 substances banned by many major athletic organizations. Warnings state that the product is contraindicated in anyone with a history of hypersensitivity to its ingredients, that the omega-3 fatty acids are derived from fish, and that pregnant users should consult a health-care practitioner before use. The page reports no known adverse interactions or contraindications at publication date. Frequently asked questions describe Super EPA as designed for adults seeking omega-3 fish oil support for heart, brain, skin, and joint health, and distinguish it from Super EPA Pro and Omega-3 with CoQ10.
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Study, Trial or Testing Result Summary
Members OnlyHuman studies
This product is a fish oil softgel from Thorne. Each softgel lists 425 milligrams of eicosapentaenoic acid and 270 milligrams of docosahexaenoic acid, two omega 3 fats, with mixed vitamin E forms added to keep the oil fresh. For the goal of cholesterol and blood fats, no study findings on these ingredients were supplied to us, and the research notes that no human studies on this goal were found for its ingredients. Because of that, we cannot point to trial results showing whether this product changes cholesterol or other blood fat levels, and no study references can be given here. What we do have is buyer feedback. Ratings are strongly positive, and a few buyers say their triglyceride or cholesterol numbers improved or stayed stable while taking it. These are personal reports, not controlled tests, and they cannot show that the softgels caused the change. Buyers most often praise the lack of a fishy taste or smell and the easy-to-swallow softgels. Anyone using fish oil to manage cholesterol should treat it as a possible support alongside advice from their doctor, not as a proven treatment based on the evidence given here. Animal and cell studies are never counted.
Review Totals and Summary
Members Only5,081 reviews · 92% positive
Thorne Super EPA 425 mg softgels are rated very positively, with about 3841 ratings across the stores and most buyers giving 4 or 5 stars. Buyers mainly praise the quality, the brand's reputation and the lack of fishy aftertaste. The few complaints concern one seller's shipment, not the softgels themselves. **What buyers say it did for them:** Several people mention cholesterol or lipid numbers. One reports "helped lower my tryglcerides and my doctor was very pleased" after a year, and another says "My cholesterol levels are stable, and this helps me maintain them." Others describe a general lift in wellness, such as "I feel a real difference in my overall wellness," though the reviews give no specific outcomes. One store page also mentions support for inflammatory response, mood, heart, brain and insulin response, but that comes from the page summary, not from a review. **What they complain about:** There is almost nothing about the softgels themselves. The one clearly negative review is about the seller: the item arrived with an expiry date a month away ("Item expires in a month"), and the buyer got a refund but won't buy from that seller again. One store's page shows a spread of lower star ratings (16 three-star, 9 two-star and 14 one-star out of 391), but the written reviews copied here don't explain them. Another store's written feedback contains no complaints about price, size or packaging. **Taste, smell, pill size and form:** This is the most common theme. Buyers say "They do not leave that fishy taste in your mouth" and "One of the few Omega 3's that doesn't have a fishy smell." Burping is not entirely absent, as one reviewer notes "Very minimal 'fish' burps experienced," while another had none, unlike with other fish oils. Reviewers also call the softgels "easy to swallow," and one noted the bottle arrived well sealed with fresh-looking capsules. Only softgel feedback is used here; reviews of other forms were left out. **Value for money:** Price is rarely discussed. One buyer says they "Found the quality to be very high for the value." Otherwise the store summaries note no price complaints. One reviewer is a subscriber and plans to continue. **Who it seems to suit and who it didn't:** It suits people who want a high EPA content, one buyer's reason for choosing it, and those who dislike fishy aftertaste. One person who had chosen vegan options to avoid the smell was impressed enough to praise this one. Several were steered to it by a physician, naturopathic doctor or family member, and many cite trust in the Thorne brand and its independent lab testing. Nobody in these reviews says the softgels didn't suit them. The only unhappy buyer had a seller problem with a near-expiry bottle, so it is worth checking the expiry date on arrival.
Biohacker Summary
Members Only7 of 10 recommend it
Omega-3 fatty acids are only a smaller ingredient in this product, but all ten panelists spoke about them, and six of the ten lean toward recommending them while four stay neutral. They take them mainly for heart health and triglycerides, brain function, lower inflammation, slower biological aging, fertility, and skin. Several get omega-3s from fatty fish such as salmon and sardines, while others favor fish oil, and one advised taking them with a meal that contains fat to help absorption. Doses mentioned run from 1 gram a day up to 2 to 4 grams a day of combined EPA and DHA, and one panelist warned that most people underdose because standard capsules hold little EPA and DHA. One panelist said the research on omega-3s is not strong for preventing hard heart disease outcomes, and no one reported stopping them.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Omega-3 Fatty Acids · recommends
- Recommends wild-caught salmon as a healthy food to eat every day, noting it contains about 2000 mg of omega-3s in just 3 ounces.
- Recommends wild salmon as it is rich in omega-3 fatty acids, which help reduce inflammation and support brain health and cognitive function, especially important as one ages.
- Recommends DHA, an omega-3 fatty acid, as a natural remedy that, along with sweet wormwood, can trigger iron into an explosion to hit cancer.
- Dr. Eric Berg mentions that sardines are packed with omega-3 fatty acids, which support brain health and metabolism.
- Mentions that wild salmon, specifically half a fillet, has 970 mg of potassium, zero carbohydrates, a good amount of magnesium, and is loaded with omega-3 fatty acids.
- Discusses what would happen if one consumed omega-3 fatty acids every day for 30 days, highlighting their benefits for brain health, heart health, and various conditions like dry eyes, dermatitis, and high blood pressure, as well as supporting calcium absorption and promoting better sleep.
- Recommends getting plenty of omega-3 fatty acids to support joint and metabolic health.
- Recommends consuming foods rich in vitamin D, including fatty fish, to boost vitamin D levels.
- Recommends fatty fish as the best type of protein for inflammation.
- Recommends fatty fish, including salmon, mackerel, and sardines, as dietary sources of vitamin D.
Siim Land · Omega-3 Fatty Acids · recommends
- Recommends taking omega-3s, including EPA and DHA, with a fat-containing meal to increase absorption.
- Increased his omega-3 intake to achieve a higher omega-3 index, which is associated with greater insulin sensitivity and better metabolic health markers.
- Increased his omega-3 index to 9.5% and notes that omega-3s have strong evidence for reducing elevated triglycerides.
- Mentions that EPA and DHA Omega-3s support heart and brain function and can lower triglycerides, with a higher omega-3 index associated with lower heart disease, Alzheimer's and mortality risk.
- Recommends Omega-3s for triglycerides and cardiovascular health, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Recommends choosing an omega-3 supplement from a brand that uses independent third-party testing and publishes a recent certificate of analysis, verifying EPA and DHA amounts, and testing for heavy metals, contaminants, and oxidation markers.
- Lists Omega-3s as one of 15 supplements backed by human studies.
- Explains that omega-3s can alter mitochondrial membranes and have broader cardiometabolic effects, making mitochondria more responsive to cellular signaling and oxidative stress from exercise, but they don't increase maximal mitochondrial respiration.
- Notes that 75% of people aren't meeting the daily recommendation for omega-3s and that Japanese people eat 2-3x more omega-3s per day than Americans or Europeans, which reflects in their higher omega-3 index.
- Thinks omega-3s have some of the strongest evidence and are worth considering.
Andrew Huberman · Omega-3 Fatty Acids · recommends
- AG1 is giving away a free bottle of omega-3 coenzyme Q10 with your first subscription.
- Mentions that AG1 is giving away a free bottle of Omega-3 co-enzyme Q10 with the first subscription to AG1 Pro.
- Discusses Omega-3 Fatty Acids and EPA.
- Mentions that AG1 is offering a free bottle of Omega-3 co-enzyme Q10 with a first subscription to AG1 Pro.
- Recommends a free bottle of Omega-3 co-enzyme Q10 with the first AG1 Pro subscription.
- Mentions Omega-3s in the context of the microbiome and processed foods.
- Recommends Omega-3 co-enzyme Q10, which is offered as a free bottle with the first AG1 Pro subscription.
- States that getting 1 to 3 grams of EPA essential fatty acid per day can improve mood and cognitive function, supporting focus and concentration.
- Discusses Omega-3 Fatty Acids.
- Discusses omega-3s, artificial sweeteners, fructose, and fats.
Thomas DeLauer · Omega-3 Fatty Acids · recommends
- Recommends fish oil supplements as an omega-3 source for gut health, as they help reduce inflammatory signaling while tissue repairs.
- Recommends high-dose omega-3s, specifically 2 to four grams of combined EPA and DHA daily, to lower hepatic fat output and improve chylomicron clearance, which helps with non-fasting triglycerides.
- Recommends omega-3s, specifically 4 grams a day, to boost the muscle building response by making muscle cell membranes work better for the mTor switch to fire, and specifically mentions Pury for their clean, third-party tested omega-3s.
- Recommends consuming more omega-3s to help balance the mitochondrial membrane, as it will absorb more omega-3s instead of omega-6s.
- Recommends consuming more omega-3s to drive down inflammation.
- Recommends omega-3s, stating that a meta-analysis found 1,000 mg significantly reduced liver fat by shutting down inflammatory signals that promote fat storage, and advises looking for a triglycerol form for better absorption and to avoid oxidation.
- Recommends fatty fish like salmon and sardines, aiming for two to three servings per week, especially around a workout, because their omega-3s, particularly DHA, increase BDNF expression.
- Considers omega-3s a fundamental for brain protection, recommending both dietary sources and supplementation for EPA and DHA, as they produce pro-resolving mediators to limit inflammation.
- Recommends timing omega-3 intake around workouts because they directly help build and keep muscle by making muscle more responsive to growth signals and fighting anabolic resistance as one ages.
- Notes that Scandinavians consume fatty fish multiple times a week as part of their diet, contributing to their long lifespan and healthspan.
Dave Asprey · Omega-3 Fatty Acids · recommends
- Suggests that omega-3s may help slow aging and support cellular repair.
- Recommends omega-3s, noting that 1 gram a day slowed epigenetic aging by up to 4 months in a randomized trial of people over 70.
- Dave Asprey recommends Omega-3, citing a randomized trial showing 1g a day slowed epigenetic aging in older adults, but warns that most people underdose due to low EPA and DHA content in standard capsules.
- A review of 41 human studies testing interventions against newer-generation epigenetic clocks found favorable changes for exercise, caloric restriction, omega-3s, plant-rich diets, multivitamins, a med, pitavastatin, and ketamine.
- Recommends getting nutrients like omega-3s from real food or Vision 101 for eyesight.
- Recommends adding omega-3 fats to improve how neurons absorb and use nutrients like vitamin C.
- States that Fatty15 supports cells better than omega-3s or fish oil, but he uses both.
- Notes that Inuit people consumed very high levels of omega-3s, specifically EPA and DHA, which contributed to their health on a whale blubber diet.
- Lists Omega-3s as a nutrient that forms the structure and different parts of the brain.
- Uses both C15 and omega-3s, noting that C15 supports cells better than omega-3s or fish oil with three times more benefits.
Dr. Rhonda Patrick · Omega-3 Fatty Acids · neutral
- Mentions that EPA is an omega-3 examined in mortality analysis and found primarily in seafood.
- States that Omega-3 fatty acids are very important for sperm health.
- Omega-3s may help slow biological aging, with added benefits when combined with vitamin D and strength training. In a 3-year randomized trial of healthy, mostly active older adults, omega-3 alone slowed several DNA-based aging clocks.
- Recommends regular intake of omega-3 rich seafood and supplementation with omega-3 fatty acids if it's appropriate for one's lifestyle, as they are beneficial for the heart by resolving inflammation and preserving membrane fluidity.
- Notes that a 100 mg per day increase in omega-3 fatty acids was associated with lowering the risk of Alzheimer's disease and cognitive decline by 10%, and that it takes about two grams a day to get to a high omega-3 index if one has a low index.
- Practical habits to help keep chronic inflammation in check include getting enough omega-3s.
- States that Omega-3s, specifically EPA and DHA, may be the most potent naturally occurring dietary compounds for reducing inflammation, and that about 2 g/day of combined EPA and DHA can raise a low omega-3 index.
- Recommends fatty fish as a source of healthy fats for muscle gain.
- Mentions that an omega-3 supplement might not be working, and one would not know without taking the Omega-3 index test.
- Recommends considering omega-3s to improve mood.
Dr. Mark Hyman · Omega-3 Fatty Acids · neutral
- Mentions omega-3 fats as existing biomarkers that play a role in mental health, which Function Health includes in their measurements.
- Mentions that omega-3s are anti-inflammatory and helpful.
- Tries to supplement with omega-3s for psoriasis and considers them the one clearly clinically effective skin nutrient for skin, hair, and nails.
- Emphasizes the importance of focusing on omega-3s, noting that a national crisis of omega-3 deficiency exists and that low omega-3 levels are a significant problem, more so than omega-6s.
- Consumes omega-3 fats through salmon at dinner.
- Notes that omega-3s are important nutrients for brain performance and aging, and that many people have gaps in these nutrients.
- Recommends omega-3 fats from wild fish, seafood, and certain nuts and seeds to fight inflammation.
- Mentions omega-3 fats as something that might be helpful for gut repair.
- Used omega-3 fats as part of a protocol to rebuild the gut microbiome and heal the gut of a nine-year-old girl with severe behavioral issues.
- States that omega-3 fats from fatty fish, flax, and walnuts help balance inflammatory pathways, but no supplement can replace daily signals from sleep, nutrition, exercise, stress management, and metabolic health.
Ben Greenfield · Omega-3 Fatty Acids · neutral
- Notes that omega-3s have solid research behind them for fertility.
- Recommends omega-3 fatty acids, specifically EPA and DHA, at 1 to 3 grams per day for better sperm morphology and motility, noting that sperm membranes are rich in polyunsaturated fatty acids.
- Recommends getting Omega-3 from oily fish such as sardines, anchovies, mackerel, herring, and salmon with skin.
- Discusses why fatty fish or fish oil may matter more than plant-based omega-3s if seed oils are in one's diet.
- Says that omega-3 fatty acids are a great way to feed the system and help with stress.
- Recommends testing for and replenishing omega-3 fatty acids if levels are low, as they can affect the ability to maintain or preserve muscle, especially for those on GLP-1s.
- Recommends including EPA from fatty fish or fish oil in one's diet, especially if seed oils are present in the diet.
- Notes that B vitamins and Omega-3s work as a pair to support the brain, but not independently.
- Notes that the DO-Health study showed omega-3 had good effects, and it's a supplement people commonly take.
- Mentions that omega-3, vitamin D, and exercise all had good effects in the DO-Health study.
Peter Attia · Omega-3 Fatty Acids · neutral
- Peter and Michael explore the benefits of omega-3 fatty acids for cardiovascular trials and the challenge of delivering DHA to the brain.
- Mentions that some trials showing a benefit to PUFA were confounded by the inclusion of omega-3s, and argues that the literature on omega-3s is not super strong for decreasing hard cardiovascular disease endpoints.
- Took big doses of omega-3 postpartum to help maintain when she wasn't sitting down to eat full meals.
- Mentions consuming fatty fish, specifically sardines, as part of their diet, noting their high fat and protein content.
- Peter discusses how omega-3s from fish oil impact inflammation, heart health, and brain function, as well as the strengths and limitations of current research.
- Mentions the importance of DHA omega-3 fatty acids for neuronal membranes, which are concentrated in synapses and crucial for communication between neurons.
- Highlights the importance of DHA omega-3 fatty acids for neuronal membranes and communication between neurons, as they are concentrated in synapses.
- Discusses the mfsd2a transporter, which is specific to DHA in phospholipid form, and its role in blood-brain barrier integrity, noting that animal studies show disruption of this transporter causes significant breakdown of the blood-brain barrier and loss of omega-3 in the brain.
- States that there is a very strong clinical impression that high doses of omega-3s help with dry eye, primarily from an anti-inflammatory standpoint.
- Recommends omega-3 fatty acids, specifically DHA and EPA, for brain protection, especially for individuals with the APOE4 gene, stating that they require higher doses.
Bryan Johnson · Omega-3 Fatty Acids · recommends
- Recommends Omega 3 fatty acids as a supplement for skin health, noting they are in the Blueprint stack.
- During menopause, Bryan Johnson recommends ensuring adequate omega-3s for brain health.
RAL Summary
Members OnlyTier 4 for Cholesterol
Tier 3 needs some study support, but no ingredient findings were given and the record states there are no human studies on this goal for its ingredients, so the evidence is thin and supports tier 4. So it is graded Tier 4, lower than the rules alone gave.
- Emerging: not enough evidence to rank higher yet.
- No human studies on this goal for its ingredients.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Cardiovascular system
Combine with: Super EPA is a concentrated EPA/DHA fish oil, and its main lipid benefit is lowering elevated triglycerides. It has a modest effect on overall cholesterol, and LDL can sometimes rise slightly. It pairs well with soluble fiber such as psyllium or beta-glucan, plant sterols/stanols, and bergamot extract, which target LDL cholesterol. Red yeast rice or berberine may add LDL support, but check with a clinician first, especially if you take meds or other medications. Niacin may also help, though it should be used under medical guidance. CoQ10 or ubiquinol is a good companion if you are on a med. Vitamin E (mixed tocopherols) can help protect the oils from oxidation. Magnesium and vitamin K2 support broader cardiovascular health. Take with a meal containing fat for better absorption. People on meds should consult a doctor because high-dose omega-3s may increase bleeding risk.
Possible side effects: No side effects from studies were given. Buyers mention only very minimal fishy burps in some cases.
Supplement Facts
Total Omega-3 Fatty Acids 813 mg
| Calories | 10 | |
| Total Fat | 1 g | |
| Total Omega-3 Fatty Acids | 813 mg | † |
Other ingredients: Bovine Gelatin, Water, Purified, Glycerin, Vitamin E.
Directions: Suggested use: Take 1 gelcap two to three times daily or as recommended by your health-care practitioner.
Barcode (UPC) 693749608059 · Label source: NIH label database · Report a label change
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Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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