Thorne Super EPA - NSF Certified for Sport Review
Super EPA contains EPA and DHA, two vital omega-3 fatty acids, important throughout adulthood, as well as during periods of increased brain growth that characterize prenatal and postnatal development. Thorne Super EPA provides the highest quality, purest fish oil available from sustainably sourced cold-water fish. The product is listed as NSF Certified for Sport and is described as a best-selling Thorne formula for more than three decades. Each softgel provides 425 mg EPA and 270 mg DHA, and the page says the ethyl ester molecular form gives a more concentrated EPA/DHA content with fewer capsules. Benefits listed include support for blood vessel health and healthy blood flow, healthy triglyceride levels, a healthy inflammatory response in joints, muscles and the body, immune modulation, nutritional support for healthy fetal brain development, positive mood, cognitive and brain health, healthy skin, and weight management through a healthy insulin response. The page states the fish oil is sustainably harvested to ensure a stable supply, and that molecular distillation removes contaminants including PCBs and heavy metals. Thorne says the formula is selected and tested through multiple rounds of quality control for purity, potency, and consistency, and that it is trusted by health-care practitioners. For athletes, the page explains that every batch of an NSF Certified for Sport product is tested for compliance with label claims and for the absence of nearly 300 substances banned by many major athletic organizations. The warnings section says the product is contraindicated for individuals with a history of hypersensitivity to any of its ingredients, that the omega-3 fatty acids are derived from fish, that pregnant people should consult a health-care practitioner before use, and that there are no known adverse interactions or contraindications at publication date. The FAQ describes Super EPA as designed for adults seeking omega-3 fish oil support for heart, brain, skin and joint health. It compares Super EPA with Super EPA Pro, which provides more EPA and DHA in an approximately 2:1 ratio, and Omega-3 with CoQ10, which adds CoQ10. The page lists the product as 90 gelcaps with a serving size of one gelcap.
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Study, Trial or Testing Result Summary
Members Only84 human studies · 47 improved
This product's main omega-3 fats are EPA and DHA. The label names DHA but does not show an amount, so the dose cannot be compared with the studies. The store listing gives 270 milligrams of DHA and 425 milligrams of EPA per softgel, well below the 1.2 to 4 grams a day of pure DHA used in the trials. Across 32 trials with 2,385 people, omega-3 fats modestly improved how well blood vessels widen, though results varied a lot between studies [1]. A pooled analysis of 16 placebo-controlled trials with 901 people found a 2.3 point gain in vessel widening [2]. In 853 people with heart disease the gain was smaller, and inflammation markers fell [3]. Another pooled analysis found the benefit was no longer significant when only double-blind placebo-controlled trials were counted [4]. Pure DHA at 4 grams a day for 6 weeks improved forearm blood flow in 59 overweight men, while EPA did not [5]. In 20 children with high cholesterol, 1.2 grams a day of DHA improved vessel widening [6]. The evidence points to a small and inconsistent benefit for blood flow. Animal and cell studies are never counted.
See all 84 studies →Hide the studies
- Across 32 trials with 2,385 people taking omega-3 for 4 to 48 weeks, blood vessel widening ability (flow-mediated dilation) improved by 0.8 percentage points, though results varied a lot between studies.Omega-3 fatty acids and endothelial function: A GRADE-assessed systematic review and meta-analysis.
- Across 16 studies with 1,385 people, fish oil improved blood vessel widening by 1.49%, but when only double-blind placebo-controlled studies were counted the effect was not significant.Effect of fish oil supplementation on fasting vascular endothelial function in humans: a meta-analysis of randomized con…
- Across 16 placebo-controlled trials with 901 people taking 0.45 to 4.5 grams a day for a median of about 8 weeks, omega-3 raised blood vessel widening ability by 2.3 percentage points versus placebo, with no change in endothelium-independent dilation.Effect of omega-3 fatty acids supplementation on endothelial function: a meta-analysis of randomized controlled trials.
- Across 13 trials with 853 people with chronic heart disease, omega-3 raised blood vessel widening ability by 0.34 percentage points versus placebo and lowered inflammation markers.Effect of omega-3 fatty acid supplementation on markers of inflammation and endothelial function in patients with chroni…
- Across twelve trials of 847 people with type 2 diabetes taking omega-3 fats for about 8.5 weeks, diastolic blood pressure fell slightly (1.8 mm Hg) and a clotting factor (factor VII) rose, with no change in systolic blood pressure, fibrinogen or heart rate.Meta-analysis of the effects of n-3 polyunsaturated fatty acids on haematological and thrombogenic factors in type 2 dia…
- Across 14 randomized trials, fish oil reduced artery stiffness measured by pulse wave speed, especially at low doses, but did not change the augmentation index.Clinical effectiveness of fish oil on arterial stiffness: A systematic review and meta-analysis of randomized controlled…
- In a review of 14 diet trials in people with lupus, omega-3 supplements were reported to reduce inflammation and oxidative stress and improve blood vessel function and blood fats.Diet and Systemic Lupus Erythematosus (SLE): From Supplementation to Intervention.
- A review of 23 observational studies in healthy Asian adults linked higher blood omega-3 levels to lower hypertension and heart attack risk, but found no consistent link with artery stiffness.Biomarkers of PUFA and cardiovascular risk factors and events in healthy Asian populations: a systematic review.
- A narrative review found omega-3 slightly lowered blood pressure, especially in people with high blood pressure or high heart risk, but results varied with dose, EPA to DHA ratio and duration.OMEGA-3 POLYUNSATURATED FATTY ACIDS AND HYPERTENSION: A REVIEW OF VASOACTIVE MECHANISMS AND IMPLICATIONS FOR CARDIOVASCU…
- In 20 randomized trials, slightly more than half showed lower artery stiffness with omega-3 while the rest showed no change, with benefits more common at about 1.8 to 4 grams a day for 12 weeks or longer.Effectiveness of Omega-3 Supplementation on Arterial Stiffness: A Systematic Review.
- In 1,059 undernourished children in Guinea-Bissau, a multi-nutrient food supplement containing omega-3 given for 23 weeks increased an index of brain blood flow compared with a control meal.Effects of food supplementation on cognitive function, cerebral blood flow, and nutritional status in young children at …
- In 487 ten-year-old children whose mothers took fish oil or placebo in pregnancy, those in the fish oil group had lower brain blood flow and oxygen use, which were not linked to mental health or thinking ability.Fish oil-derived fatty acids in pregnancy and brain metabolism in middle childhood: results from a randomized controlled…
- In 312 healthy adults taking fish oil with 0.7 or 1.8 g of EPA plus DHA daily for 8 weeks each, blood pressure and small blood vessel function did not change overall, but the 31 people with isolated high systolic blood pressure had about a 5 mm Hg drop.Consumption of Fish Oil Providing Amounts of Eicosapentaenoic Acid and Docosahexaenoic Acid That Can Be Obtained from th…
- In 240 middle-aged and older adults given 0, 1, 2 or 4 g of fish oil daily for 12 weeks, the 1 g group had larger drops in two blood vessel inflammation markers than the control group, but nitric oxide, endothelin-1 and oxidized LDL showed no between-group differences.Effects of fish oil supplementation on biomarkers of vascular endothelial function in middle-aged and older adults: a ra…
- In 173 healthy adults aged 40 to 65, 8 months of tuna fish oil improved blood vessel responses to acetylcholine compared with placebo, while other oils had no effect.The effects of dietary fatty acid supplementation on endothelial function and vascular tone in healthy subjects.
- In 150 people with high triglycerides (50 per group), 2 g of omega-3 fatty acids daily for 2 months lowered triglycerides by 21% and improved blood vessel dilation, similar to fenofibrate.Significant differential effects of omega-3 fatty acids and fenofibrate in patients with hypertriglyceridemia.
- In 150 people with high triglycerides (50 per group), 2 g of omega-3 plus fenofibrate daily for 2 months improved blood vessel dilation and lowered inflammation markers versus placebo, but not more than fenofibrate alone.Vascular and metabolic effects of omega-3 fatty acids combined with fenofibrate in patients with hypertriglyceridemia.
- In 140 women with unexplained low amniotic fluid, 4 weeks of omega-3 capsules, compared with placebo, significantly raised amniotic fluid levels and lowered uterine artery resistance and pulsatility measures, which may reflect better uterine blood flow.A randomized controlled study of the efficacy of 4 weeks of supplementation with ω-3 polyunsaturated fatty acids in case…
- In 97 people with type 2 diabetes, 4 grams a day of fish oil for 12 weeks did not improve blood vessel dilation compared with olive oil, though triglycerides and kidney function improved.Fish-oil supplement has neutral effects on vascular and metabolic function but improves renal function in patients with …
- In 90 kidney transplant recipients, 9 or 18 g of EPA daily for 26 weeks did not change kidney blood flow compared with corn oil, though diastolic blood pressure fell.Delayed omega-3 fatty acid supplements in renal transplantation. A double-blind, placebo-controlled study.
- In 86 healthy older adults, six months of DHA alone or with other nutrients did not change blood flow in the brain or thinking performance.DHA Supplementation Alone or in Combination with Other Nutrients Does not Modulate Cerebral Hemodynamics or Cognitive Fu…
- In 84 adults at moderate heart risk, 1.5 g of omega-3 fatty acids daily for 8 weeks increased circulating vessel repair cells and reduced vessel damage particles, but did not change vascular function tests.Fish-oil supplementation alters numbers of circulating endothelial progenitor cells and microparticles independently of …
- In 80 obese middle-aged adults at high heart failure risk, 1.6 g daily of omega-3 capsules for one year had no independent effect on arterial stiffness, heart structure, or fitness compared with olive oil placebo.1 Year HIIT and Omega-3 Fatty Acids to Improve Cardiometabolic Risk in Stage-A Heart Failure.
- In 70 Japanese adults with higher triglycerides, 12 weeks of scallop oil (1.2 g daily, with 63 mg docosahexaenoic acid) lowered triglycerides and oxidized LDL cholesterol compared with placebo, while blood flow outcomes were not reported in the abstract.Effects of Daily Consumption of Scallop Oil Prepared from Internal Organs of Japanese Giant Scallop (Patinopecten yessoe…
- In 67 nonhypertensive people, 8 weeks of fish oil blunted heart rate and nerve-driven blood vessel responses to mental stress and changed calf blood vessel response, but did not change blood pressure or forearm blood flow response compared with placebo.Fish oil and neurovascular reactivity to mental stress in humans.
- In 65 women with metabolic syndrome, 3 grams a day of fish oil omega-3 for 90 days raised nitric oxide and adiponectin levels and lowered diastolic blood pressure from baseline.Blood pressure decrease with ingestion of a soya product (kinako) or fish oil in women with the metabolic syndrome: role…
- In 65 healthy college students in Shanghai, 2.5 grams per day of fish oil improved several blood markers of inflammation, clotting, blood vessel function and oxidative stress when air pollution levels rose, compared with placebo.Cardiovascular Benefits of Fish-Oil Supplementation Against Fine Particulate Air Pollution in China.
- In 62 adults with high blood pressure, 3.36 grams per day of omega-3 fatty acids for 3 months did not significantly reduce arterial stiffness or inflammation markers compared with placebo.Effects of omega-3 fatty acids on arterial stiffness in patients with hypertension: a randomized pilot study.
- In 62 healthy adults eating a high-fat breakfast, a single 1.76 gram dose of docosahexaenoic acid reduced meal-induced inflammation compared with placebo and raised a reactive hyperemia endothelial function score by 13.3 percent at six hours.Supplementations of docosahexaenoic acid and blueberry suppress a high-fat breakfast-induced postprandial inflammation b…
- In 60 women with metabolic syndrome, 3 grams a day of fish oil omega-3 for 90 days raised nitric oxide levels and lowered systolic blood pressure at 45 days.Nitric oxide enhancement and blood pressure decrease in patients with metabolic syndrome using soy protein or fish oil.
- In 60 people after a heart attack, 2 g daily omega-3 for 3 months lowered triglycerides and lipoprotein(a) and raised nitric oxide by 62% compared with usual care alone, suggesting better blood vessel function.Omega-3 polyunsaturated fatty acid supplementation improves lipid metabolism and endothelial function by providing a ben…
- In 59 overweight men with mildly high blood fats, 4 g a day of DHA for 6 weeks improved forearm blood flow responses and reduced constriction compared with olive oil, while EPA did not.Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcircul…
- In 59 adults, a single fat drink with DHA-rich fish oil improved artery widening, whereas saturated fat alone impaired it, a difference of about 2 percentage points.DHA-rich fish oil reverses the detrimental effects of saturated fatty acids on postprandial vascular reactivity.
- In 59 adults given a saturated fat drink with or without fish oil, artery widening fell after saturated fat alone and rose after saturated fat plus fish oil, with the biggest differences in women and in people with the Asp298 gene variant.Glu298Asp polymorphism influences the beneficial effects of fish oil fatty acids on postprandial vascular function.
- In 52 overweight adults with high blood pressure, 3 grams per day of fish oil for 8 weeks improved the elasticity of large arteries compared with placebo, without changing blood pressure.Fish oil supplementation improves large arterial elasticity in overweight hypertensive patients.
- In 50 healthy adults with a parent who has type 2 diabetes, 2 grams a day of fish oil for 12 weeks improved blood vessel widening and lowered the inflammation marker TNF-alpha, while the placebo group showed no change.Fish oil supplementation improves endothelial function in normoglycemic offspring of patients with type 2 diabetes.
- In 48 pregnant women, 450 mg of DHA daily for 8 weeks in the third trimester did not change fetal ductus arteriosus blood flow or constriction compared with placebo.Maternal supplementation with docosahexaenoic acid does not cause constriction of fetal ductus arteriosus: randomized co…
- In 39 adults with abdominal obesity, seven weeks of fish oil at 3-4 grams per day was compared with safflower oil; blood pressure fell with fish oil relative to safflower oil, but circulating inflammatory markers did not differ between the two oils.Inflammatory markers after supplementation with marine n-3 or plant n-6 PUFAs: A randomized double-blind crossover study…
- In 38 healthy adults aged 40 to 65, 0.7 g of DHA daily for 3 months lowered diastolic blood pressure by about 3 mm Hg compared with olive oil, but did not change arterial stiffness or blood vessel function.Low-dose docosahexaenoic acid lowers diastolic blood pressure in middle-aged men and women.
- In 38 borderline hypertensive older adults, 20 weeks of DHA-rich fish oil (1600 mg daily) improved brain blood flow response in women and brain blood flow response to thinking tasks in men, but not brain blood flow response to carbon dioxide in men, with no change in mood or cognition.Effects of Long Chain Omega-3 Polyunsaturated Fatty Acids on Brain Function in Mildly Hypertensive Older Adults.
- In 37 people with high blood fats taking 2 g or 4 g daily of omega-3 for 8 weeks, blood vessel widening (flow-mediated dilation) while fasting did not improve, though after-meal triglycerides fell at both doses.Discrepancy Between Fasting Flow-Mediated Dilation and Parameter of Lipids in Blood: A Randomized Exploratory Study of t…
- In 34 people with familial high cholesterol on meds, 4 grams a day of marine omega-3 fats for 3 months did not change blood vessel function compared with olive oil placebo.Read the study on PubMed (31543373) →
- In 32 patients with Raynaud's phenomenon, fish oil capsules delayed attacks of finger blood flow loss and improved blood flow in the cold, with 5 of 11 patients with primary Raynaud's no longer developing attacks.Fish-oil dietary supplementation in patients with Raynaud's phenomenon: a double-blind, controlled, prospective study.
- In 30 South Asians with dyslipidemia, 4 g daily of omega-3 fatty acids added to a med for 8 weeks improved endothelial vessel dilation and lowered triglycerides compared with a med alone.Read the study on PubMed (19337557) →
- In 29 adults with high triglycerides and high blood pressure, 1800 mg per day of omega-3 fatty acids for 12 weeks reduced arterial stiffness and improved blood vessel function in those at high cardiovascular risk.Omega-3 fatty acids supplementation improves endothelial function and arterial stiffness in hypertensive patients with h…
- In 28 Japanese elderly adults, 240 mg per day of DHA plus 240 mg per day of arachidonic acid for 3 months increased coronary blood flow reserve compared with placebo.Arachidonic acid and docosahexaenoic acid supplementation increases coronary flow velocity reserve in Japanese elderly i…
- In 28 heart transplant recipients, 4 g of omega-3 fatty acids daily for 6 months prevented the blood pressure rise seen with placebo and preserved blood vessel responses to reduced blood flow.Hypertension prophylaxis with omega-3 fatty acids in heart transplant recipients.
- In 26 healthy adults, 1 g of fish oil daily for 14 days improved blood vessel widening and lowered resting heart rate compared with corn oil placebo.Cardiovascular and endothelial effects of fish oil supplementation in healthy volunteers.
- In 26 adults with moderately high triglycerides, 8 weeks of 3.4 g EPA and DHA per day lowered triglycerides but did not improve endothelial function, and the lower 0.85 g dose had no effect.Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons…
- In 25 healthy men, a single meal containing 9 g of fish oil improved blood vessel widening compared with a placebo oil meal, measured 4 hours after eating.Fish oil fatty acids improve postprandial vascular reactivity in healthy men.
- In 25 adolescents with high triglycerides, 6 months of high-dose omega-3 supplements was well tolerated, but the triglyceride drop was not significantly greater than with placebo and endothelial function did not differ between groups.Using high-dose omega-3 fatty acid supplements to lower triglyceride levels in 10- to 19-year-olds.
- In 24 healthy young adults whose arm was immobilised for two weeks, 390 mg of docosahexaenoic acid daily with EPA did not change arterial resting blood flow compared with placebo.Omega-3 Fatty Acids and Vitamin D in Immobilisation: Part B- Modulation of Muscle Functional, Vascular and Activation Pr…
- In 24 people with leg artery disease, 3 months of 4.4 g daily fish oil raised protective lipid mediators but did not change blood vessel dilation, inflammation, or walking ability compared with placebo.Fish Oil Increases Specialized Pro-resolving Lipid Mediators in PAD (The OMEGA-PAD II Trial).
- In 24 adults at risk of metabolic syndrome, eating two omega-3 enriched eggs daily for 3 months did not change endothelial function, which is a measure of blood vessel health, compared with control eggs.A Three-Month Consumption of Eggs Enriched with ω-3, ω-5 and ω-7 Polyunsaturated Fatty Acids Significantly Decreases the…
- In 23 people with type 2 diabetes, fish oil capsules taken for 6 weeks improved blood vessel widening in response to acetylcholine compared with olive oil capsules, while responses to nitroglycerin did not change.Dietary fish oil augments nitric oxide production or release in patients with type 2 (non-insulin-dependent) diabetes me…
- In 22 healthy young adults, 1 gram a day of DHA-rich fish oil for 12 weeks increased blood flow in the prefrontal brain region during thinking tasks compared with placebo.DHA-rich oil modulates the cerebral haemodynamic response to cognitive tasks in healthy young adults: a near IR spectros…
- In 21 men, three weeks of fish oil increased blood flow speed in tiny nailfold capillaries by about 1.75 times, while olive oil made no change.Fish oil increases peripheral capillary blood cell velocity in humans.
- In 20 patients aged 65 and older with chronic heart failure, 6 weeks of 3 g omega-3 fatty acids per day increased the forearm blood flow response to acetylcholine compared with olive oil.Effects of dietary omega-3 fatty acid supplementation on endothelium-dependent vasodilation in patients with chronic hea…
- In 20 healthy adults, a single fish oil dose of about 1 g EPA and DHA taken with a high-fat meal kept blood vessel flow-mediated dilation at baseline levels, while the placebo group's dilation was impaired.The effect of acute fish-oil supplementation on endothelial function and arterial stiffness following a high-fat meal.
- In 20 healthy smokers, 2 grams a day of omega-3 fatty acids for 12 weeks improved artery dilation and arterial stiffness compared with placebo, and lowered inflammatory markers TNF-alpha and IL-6.Effects of Ω-3 fatty acids on endothelial function, arterial wall properties, inflammatory and fibrinolytic status in sm…
- In 20 male smokers, 2 g daily of omega-3 for 6 weeks improved forearm blood vessel widening and clot-dissolving release compared with placebo, with no change in platelet activation.Effect of ω-3 fatty acid supplementation on endothelial function, endogenous fibrinolysis and platelet activation in mal…
- In 20 adults with familial hypercholesterolaemia on meds, 4 grams per day of omega-3 fatty acids for eight weeks increased large artery elasticity by 9 percent and lowered systolic blood pressure by 6 percent.Read the study on PubMed (27614801) →
- In 19 healthy men, eight weeks of fish oil providing 260 mg of docosahexaenoic acid daily did not prevent the leg blood vessel dysfunction caused by three hours of sitting compared with placebo.Eight weeks of fish oil supplementation does not prevent sitting-induced leg endothelial dysfunction.
- In 18 patients with cardiac syndrome X, 1440 mg a day of omega-3 fatty acids for 4 months improved blood vessel widening and lowered the oxidative stress marker malondialdehyde.ω-3 fatty acid treatment in cardiac syndrome X: a double-blind, randomized, placebo-controlled clinical study.
- In virologically suppressed HIV-infected men, 1 gram of omega-3 ethyl esters twice a day for 24 weeks did not improve endothelial function compared with placebo, although inflammation showed a non-significant trend toward improvement.Omega-3 fatty acids do not improve endothelial function in virologically suppressed HIV-infected men: a randomized place…
- In 80 adults with metabolic syndrome, 2.4 grams of omega-3 a day for three months improved endothelial function compared with placebo.The Role of Omega-3 Polyunsaturated Fatty Acids in Patients with Metabolic Syndrome and Endothelial Dysfunction.
- In 54 people with heart disease, 5.1 g a day of omega-3 fats lowered clotting-related blood markers, while markers of vessel inflammation rose in the group switched from placebo.The effect of supplementation with omega-3 fatty acids on soluble markers of endothelial function in patients with coron…
- In 39 people with type 2 diabetes and nerve damage affecting the heart, three months of omega-3 fatty acids added to usual treatment reduced measures of arterial stiffness compared with usual treatment alone.[The effect of long-chain polyunsaturated ω-3 fatty acids on the arterial stiffness parameters in patients with diabetes…
- In 29 healthy volunteers, a fish oil concentrate taken for 3 weeks raised daily urinary nitrate excretion by 43% compared with placebo, suggesting increased nitric oxide production.n-3 fatty acids and urinary excretion of nitric oxide metabolites in humans.
- In 22 patients with variant angina, 1.8 g per day of purified EPA for 4 months improved coronary vessel response to acetylcholine at non-spasm sites, but did not prevent acetylcholine-induced coronary spasm at spasm sites.Improvement of coronary vasomotion with eicosapentaenoic acid does not inhibit acetylcholine-induced coronary vasospasm …
- In 20 children with high cholesterol, 1.2 grams a day of docosahexaenoic acid for 6 weeks improved blood vessel widening compared with placebo and diet alone.Docosahexaenoic acid restores endothelial function in children with hyperlipidemia: results from the EARLY study.
- In 18 people with high triglycerides, 5 weeks of EPA and DHA (760 mg DHA plus EPA per day, taken as two doses) improved blood vessel dilation compared with placebo.Eicosapentaenoic and Docosahexaenoic Acid Supplementation Increases HDL Content in n-3 Fatty Acids and Improves Endothel…
- In 14 heart transplant recipients, 5 grams a day of fish oil for 3 weeks restored normal widening of coronary arteries in response to acetylcholine, while the control patients showed narrowing.Fish oil improves endothelium-dependent coronary vasodilation in heart transplant recipients.
- In 13 healthy adults, 6 weeks of 2.0 g DHA and 3.0 g EPA per day enhanced blood vessel widening and blood flow in the arm during exercise, while the placebo group saw no change.Supplementation with omega-3 polyunsaturated fatty acids augments brachial artery dilation and blood flow during forearm…
- In 13 elite cyclists, 2.6 grams a day of omega-3 fats for 3 weeks raised nitric oxide levels and improved blood vessel widening and maximal oxygen uptake compared with placebo.Omega-3 fatty acids supplementation improves endothelial function and maximal oxygen uptake in endurance-trained athlete…
- In 10 healthy volunteers, 4 g daily of omega-3 for 4 weeks reduced the drop in blood vessel widening after a fatty meal and lowered the after-meal rise in triglycerides compared with no treatment.Omega-3 fatty acids improve postprandial lipemia and associated endothelial dysfunction in healthy individuals - a rando…
- In 8 men with high triglycerides, 1800 mg per day of EPA for 3 months brought blood vessel widening in the forearm back to the level seen in people without high triglycerides, though it also made their fats more prone to oxidation.Eicosapentaenoic acid improves endothelial function in hypertriglyceridemic subjects despite increased lipid oxidizabili…
- In 24 healthy offspring of heart disease patients, 9 g per day of fish oil for 2 weeks did not improve blood vessel function or nitric oxide levels compared with before treatment.Impaired nitric oxide production, brachial artery reactivity and fish oil in offspring of ischaemic heart disease patien…
- In 16 healthy adults, 8 weeks of 6 g fish oil per day lowered triglycerides and raised nitric oxide metabolites, but also raised homocysteine by 20 percent and did not change LDL oxidation.Effect of fish oil on LDL oxidation and plasma homocysteine concentrations in health.
- In 10 healthy young men, 4 weeks of fish oil at 4.2 grams per day increased resting blood flow in the thigh artery, with no control group.Fish oil supplementation, resting blood flow and markers of cellular metabolism during incremental exercise.
- In a population study of 1464 people without overt heart disease, higher omega-3 intake from food was linked to arterial stiffness differently depending on a gene variant, and high intake reduced the gene-related differences; this was not a supplement trial.Fatty acid desaturase genetic variations and dietary omega-3 fatty acid intake associate with arterial stiffness.
- In 166 psychiatric referral patients, higher blood omega-3 levels were linked with greater blood flow in some brain regions on SPECT imaging, but this was a correlation and not a treatment test.Quantitative Erythrocyte Omega-3 EPA Plus DHA Levels are Related to Higher Regional Cerebral Blood Flow on Brain SPECT.
- In 22 healthy adults, brain DHA uptake and blood flow did not differ overall between APOE4 gene carriers and non-carriers, though DHA uptake was higher in some brain regions among carriers; no dose was given and the study did not test a supplement.DHA brain uptake and APOE4 status: a PET study with [1-11C]-DHA.
- A 2002 literature review linked omega-3 fats to lower heart-related death risk and proposed improved endothelial function as one possible mechanism, which was not directly measured.Evidence for the cardioprotective effects of omega-3 Fatty acids.
Review Totals and Summary
Members Only61,434 reviews · 93% positive
Across the store, Thorne's Super EPA softgels show 61,045 ratings (391 on the Thorne page itself), and the themes below come from the written reviews that could be read on that page. Only a handful of short reviews were readable, and nothing about other forms of the product appeared, so none were left out. **What buyers praise.** Customers describe the product as high quality and say they feel good about taking it. The page's AI-generated summary says reviewers appreciate the quality, noticeable improvements in wellness, and the absence of fishy taste or burps. The product is also credited with supporting a healthy inflammatory response, mood, heart, brain, and insulin response. Recurring themes in the highlighted reviews are product quality, no fishy taste, ease of taking it, and perceived benefits for heart, mood, and inflammation. **Individual reviews.** One buyer, who had taken it for a little over a month, said they were liking it very much. A daughter who also takes it had recommended it. The lack of fishy aftertaste mattered to them because it had been their first question. They subscribed and plan to keep taking it. Another reviewer wrote a short note saying they had great feelings about the quality and that the product delivers. Two others, titled "Very good" and "Thumbs up," gave brief praise without detail. A buyer focused on cardiovascular health said their cholesterol levels were stable and that the supplement helps them maintain them, adding that they trust Thorne vitamins. **Complaints and lower ratings.** Few complaints appear in the visible text. The rating breakdown shows 17 four-star, 16 three-star, and 23 combined one- and two-star ratings, so some buyers were less satisfied. The written excerpts do not explain the reasons for those lower ratings. The visible reviews also say nothing specific about pill size, aftertaste problems, or price as complaints. **Who it seems to suit.** The feedback points to people interested in heart health, including those monitoring cholesterol, as well as buyers looking for mood, inflammation, brain, or insulin-response support. It also suits people wary of fish-oil aftertaste or burps, and people who already trust the Thorne brand or who were referred by family. The subscription mention suggests it works for those wanting a regular, ongoing supplement. **Taste, form, and value.** Taste is the most concrete point: reviewers say there is no fishy aftertaste or burping, and one found it easy to take. The page lists popular topics including results, quality, feel, issues, improvement, skin, benefits, and price, which suggests these are what buyers mention most often. However, the readable reviews give no detail on price or value. **Overall.** The reviews shown lean toward satisfaction with quality and tolerability. They are short and mostly positive in tone, though the lower star ratings show not everyone was happy and the reasons are not given.
Biohacker Summary
Members Only7 of 10 recommend it
Our biohacker panel has not discussed this product’s ingredients yet.
RAL Summary
Members OnlyTier 3 for Circulation
Tier 3 rests on a very large number of reviews, 93% of them positive, along with some study support. Pooled trials show small gains in blood vessel widening, but the benefit fades in double-blind trials alone [PMID:37859571, PMID:23029372].
- DHA: amount hidden in a blend
Where the evidence disagrees: 18 of the 84 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Cardiovascular system
Combine with: For cholesterol management, pair this with ingredients that have direct LDL-lowering evidence, such as plant sterols/stanols (about 2 g daily), soluble fiber like psyllium or beta-glucan, bergamot extract, and red yeast rice (ideally citrus-free, with monitoring and a clinician's guidance, because it contains monacolin K, which acts like a med). Berberine and bempedoic-style support from a clinician may also be considered. Citrus bergamot and niacin (under medical supervision) can help improve lipid profiles. CoQ10 is a good companion if using red yeast rice or meds. For circulation and heart support, magnesium, vitamin K2, and vitamin E (mixed tocopherols/tocotrienols) complement omega-3s. Talk with a healthcare provider before combining fish oil with meds or before starting red yeast rice.
Possible side effects: No major side effects reported.
Supplement Facts
Total Omega-3 Fatty Acids 813 mg · EPA 425 mg · DHA 270 mg
| Calories | 10 | |
| Total Fat | 1 g | |
| Total Omega-3 Fatty Acids | 813 mg | † |
| EPA | 425 mg | † |
| DHA | 270 mg | † |
Other ingredients: Softgel (Gelatin (bovine), Purified Water, Glycerin (vegetable source)), Vitamin E (mixed tocopherols).
Directions: Take 1 softgel two to three times daily or as recommended by your health-care practitioner.
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Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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