Thorne Vitamin D Review

Thorne Vitamin D-5,000 is a capsule that supplies 5,000 IU of vitamin D3 per capsule and is NSF Certified for Sport. The page presents the product as a way to support healthy teeth, bones, and muscles, as well as cardiovascular and immune function. Thorne states that vitamin D in its D3 form is more potent and better absorbed than the D2 form. The product contains no lactose and no preservatives, and the page says it is free from lactose, preservatives, gluten, and soy. Each serving is one capsule taken daily, and the bottle contains 60 servings. The listed ingredient is Vitamin D3 at 125 mcg per capsule, with other ingredients of leucine, microcrystalline cellulose, silicon dioxide, hypromellose derived from cellulose for the capsule, and vitamin E as d-alpha-tocopherol. The page lists benefits including support for healthy teeth and bones, promotion of lean muscle mass and help maintaining muscle strength, enhancement of calcium absorption and retention, support for healthy brain function, and promotion of cardiovascular health and immune function. The page explains that many people, especially older adults, do not get enough vitamin D from sunlight or diet, and it lists groups who may benefit, including people who rarely go outdoors, people with limited sun exposure, regular sunscreen users with SPF above 8, older adults, people with chronic conditions that reduce fat absorption, and people with obesity. It notes that the optimal amount of vitamin D varies and should be individualized, and it mentions that either D-1,000 or D-5,000 can be used to maintain optimal vitamin D levels in healthy individuals. The page also describes NSF Certified for Sport testing, stating that every batch is tested for compliance with label claims and for the absence of nearly 300 substances banned by many major athletic organizations. The warnings section states the product is contraindicated for anyone with a history of hypersensitivity to its ingredients, advises pregnant people to consult a health-care practitioner before use, and says there are no known adverse interactions at publication date. The FAQ section explains that vitamin D3 is the same form the body makes from sunlight, that it aids calcium absorption, and that vitamin K2 is discussed as a complementary nutrient for those taking vitamin D, with a note to consult a provider if on meds. Subscription options are available with a 10 percent discount, and the page lists alternatives including a liquid Vitamin D3 and D-1,000 capsules.

Product Focus: Bone HealthAlso covers:Hormones
Tier ⓘ
Tier 4 · Rank 2
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 2 within Tier 4 for Bone Health; 30 of 46 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
60 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
96% of 6,215
Biohacker Mentions
8 of 10
Cost per month
$10

Study, Trial or Testing Result Summary

Members Only13 human studies · 2 improved
13 human studies2 improved3 no effect71,314 people studied

Human studies of vitamin D for bone health disagree. A review of older adults found that 700 to 800 units a day cut hip fractures by 26% and other non-spine fractures by 23%, while 400 units a day did not help [1]. A review of nine studies found no clear drop in fractures with vitamin D3 [2]. In 43,869 women with thinning bones after menopause, calcium plus vitamin D slightly improved pelvic bone density but not spine or hip density, and did not reduce fractures [3]. In women after menopause without thinning bones, vitamin D improved some bone turnover measures, but a fracture benefit could not be confirmed [4]. Children whose mothers took vitamin D3 during pregnancy had denser bones at ages 6 to 7 [5]. In kidney transplant patients, vitamin D-like drugs improved bone density in two small trials, but no trial showed fewer fractures [6]. This product's vitamin D is at or above the dose that helped in the positive review. Note that the label and the store listing give different amounts per capsule. Animal and cell studies are never counted.

See all 13 studies →Hide the studies

Review Totals and Summary

Members Only6,215 reviews · 96% positive
6,215 reviews · Amazon 3,790 · Mayo Clinic Store 1,618 · Thorne 709 · Walmart 98
96% positive3% neutral1% negative

Thorne Vitamin D capsules are very well regarded, with about 4,597 ratings across the stores and nearly all of the written feedback positive. Buyers mainly praise trust in the brand, easy-to-swallow capsules and a sense that it works. This summary covers the capsules only, and reviews of other forms were left out. **What buyers say it did for them:** Several people report a benefit they could notice or measure. One says, "I have actually seen my blood work numbers Improve." Others describe a mood lift, especially in dark months: "keeping a good attitude in bad weather." Another says, "It helps me feel better all around!" The store summary also mentions energy levels. One buyer is still waiting for a checkup to see whether it corrects a deficiency, so not everyone has a confirmed result. Details on dosing outcomes, side effects or how long it took to notice a change are largely missing. **What they complain about:** Almost nothing is said against the capsules themselves. The one complaint is about delivery, where the driver left the package "in the middle of the walkway", and that is a fulfilment problem rather than a product one. One page has a few lower star ratings, but the visible text does not explain them, so their reasons are unknown. **Taste, smell, pill size and form:** The capsules are described as small and easy to swallow: "Small capsules, easy to swallow." One buyer says the vitamin "sits well when eaten with food." Buyers also like the small bottle with no wasted packaging. The store summary notes the product is made in the USA. Taste and smell are not mentioned. **Value for money:** Opinions lean favourable but differ a little. Some call it a bargain: "High quality product at a great price from Walmart!" and "Affordable quality vitamin D." One buyer says it costs more than alternatives but is worth it: "More expensive but worth it." So the price may feel high next to cheaper brands, yet buyers think the quality justifies it. **Brand trust and quality:** This is the most repeated theme. Buyers say, "Thorne has quality products that you can trust," and one was told by a functional medicine doctor that Thorne is the best. Another chose it for the natural ingredients and plans to buy other Thorne products. One store summary adds that the supplement is NSF Certified for Sport and contains no lactose or preservatives, which reviewers treat as a reason to trust it. Several people say they will keep buying. **Who it seems to suit and who it did not:** It seems to suit people who want a trusted, higher-quality vitamin D3 (5,000 IU) in a small capsule that is easy to swallow, including those who take it through winter or to address low levels. Several are repeat buyers. No group is reported as having a bad experience, though buyers who put price first may find it dearer than other options. Those wanting proof it corrects a deficiency should know that some reviewers are still waiting for their own test results.

Biohacker Summary

Members Only8 of 10 recommend it
8 of 10 biohackers on our panel recommend it

Vitamin D is the main ingredient, and the panel is broadly in favor: all ten spoke about it, and most either recommend it or take it themselves. People take it for immune support, bone health, brain and mood, muscle, and general health or longevity, and several say to get blood levels checked, with targets that range from 40 up to 100 nanograms per milliliter. The form named most often is D3, with daily doses of 5,000 international units from three panelists and at least 10,000 from one, and one panelist says it matters most in fall and winter when sun is scarce. For pairing, panelists mention vitamin K2 and magnesium, and one says to take it with dietary fat for better absorption rather than with other supplements in the morning. One panelist cautions that for most things there is no point taking it unless you are deficient, and no one said they stopped.

See all 10 biohackers →Hide the biohackers
  • Dr. Eric Berg · Vitamin D · warns
    • 2 Nov 2026 · warns · Facebook ↗
      Dr. Berg warns that the recommended daily intake for vitamin D is based on a massive error and that the actual necessary amount is closer to 8,895 IU, with millions remaining deficient.
    • 31 Oct 2026 · recommends · YouTube ↗
      Recommends getting vitamin D levels tested to ensure they are between 50 and 70, as vitamin D is intimately involved in regulating prostate size.
    • 30 Oct 2026 · recommends · YouTube ↗
      Recommends taking at least 10,000 IUs of vitamin D3 every single day in the winter, stating it is the most important vitamin to lower cancer risk.
    • 30 Oct 2026 · recommends · YouTube ↗
      Recommends vitamin D to support the immune system, aiming for blood levels between 80 to 100 ng per ml.
    • 25 Oct 2026 · recommends · YouTube ↗
      Recommends taking no less than 10,000 IU's of vitamin D3 for osteoporosis, alongside magnesium and K2.
    • 25 Oct 2026 · recommends · X ↗
      Recommends increasing vitamin D to restore balance and support healthy blood pressure.
    • 24 Oct 2026 · neutral · YouTube ↗
      States that a lack of vitamin D can potentially cause achy bones or crashing mood.
    • 23 Oct 2026 · recommends · YouTube ↗
      States that vitamin D is intimately involved in the immune system and recommends taking at least 10,000 IUs each day.
    • 21 Oct 2026 · recommends · YouTube ↗
      States that taking high doses of vitamin D3 for 14 days can improve mood, sleep, low back pain, skin issues, and blood pressure, as well as act as a natural anti-inflammatory and reduce susceptibility to sickness.
    • 18 Oct 2026 · neutral · YouTube ↗
      Mentions that grass-fed liver has vitamin D.
    • 18 Oct 2026 · Vitamin E · neutral · YouTube ↗
      Mentions that grass-fed liver has vitamin E.
    • 10 Oct 2026 · Vitamin E · warns · Podcast ↗
      Dr. Berg states that synthetic vitamin E may be acceptable for short-term use, but long-term use can contribute to oxidative stress.
    • 3 Oct 2026 · Vitamin E · warns · YouTube ↗
      Warns against synthetic vitamin E (dl-alpha-tocopherol) for ongoing maintenance, citing a trial where it increased prostate cancer risk and explaining that it can become a free radical and starve out necessary protective forms of vitamin E.
    • 20 Sep 2026 · Vitamin E · recommends · Facebook ↗
      Recommends taking vitamin E to block the effects of grains.
  • Dave Asprey · Vitamin D · uses
    • 1 Nov 2026 · uses · Facebook ↗
      Takes Vitamin DAKE from Suppgrade Labs.
    • 25 Oct 2026 · recommends · Podcast ↗
      Suggests that vitamin D supports brain health, muscle function, and focus.
    • 9 Oct 2026 · recommends · Podcast ↗
      Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense for male fertility, even though supplementation did not improve overall semen parameters in a randomized trial.
    • 7 Oct 2026 · uses · YouTube ↗
      States that currently, he is only taking vitamin C and vitamin D.
    • 7 Oct 2026 · Vitamin E · uses · YouTube ↗
      Dave Asprey's kids get a little bit of vitamin E every day, which helps to stabilize the bad oils they get when eating at restaurants.
    • 5 Sep 2026 · recommends · YouTube ↗
      Recommends vitamin D, noting it's actually a hormone and that most people are deficient, even those who take it, because they don't take enough.
    • 3 Sep 2026 · recommends · YouTube ↗
      States that most people on the spectrum are low in vitamin D and need more of it, mentioning his own product, Vitam DAKNE, which contains real vitamin A.
    • 29 Aug 2026 · recommends · YouTube ↗
      Dave Asprey recommends Vitamin D3 with K2, explaining D3 is a hormone made from sunlight and K2 directs calcium into bones, not arteries, highlighting its low cost, widespread deficiency, and the ability to test its effectiveness.
    • 18 Aug 2026 · recommends · YouTube ↗
      Recommends Vitamin D as one of the most important supplements for overall health.
    • 18 Aug 2026 · Vitamin E · recommends · YouTube ↗
      Recommends Vitamin E as one of the most important supplements for overall health.
    • 12 Aug 2026 · uses · Facebook ↗
      Takes Vitamin DAKE from Suppgrade Labs because D3, A, K2, and E work together.
    • 12 Aug 2026 · Vitamin E · uses · Facebook ↗
      Takes Vitamin DAKE from Suppgrade Labs because D3, A, K2, and E work together.
    • 28 Jul 2026 · uses · YouTube ↗
      Mentions taking vitamin D in the morning, comparing it to the daily dosing of testosterone.
    • 19 Jul 2026 · Vitamin E · uses · Facebook ↗
      Includes vitamin K2 as a critical ingredient in Vitamin DAKE, stating that the body needs the right fat soluble vitamins for thousands of reactions.
  • Siim Land · Vitamin D · recommends
    • 31 Oct 2026 · recommends · YouTube ↗
      Advises against taking vitamin D in the morning with other supplements because it is fat soluble and requires dietary fat for better absorption.
    • 29 Oct 2026 · recommends · Instagram ↗
      Recommends taking Vitamin D with fat for better absorption.
    • 24 Oct 2026 · neutral · Instagram ↗
      States that Vitamin D connects biology to light and that UVB reaching the skin enables its production.
    • 6 Sep 2026 · recommends · Instagram ↗
      Thinks vitamin D has some of the strongest evidence and is worth considering.
    • 6 Sep 2026 · neutral · X ↗
      Notes that Vitamin K2 pairs well with vitamin D by regulating calcium and bone mineralization.
    • 26 Aug 2026 · recommends · Instagram ↗
      Recommends taking vitamin D supplements with some fat to maximize its absorption, suggesting with food or a teaspoon of olive oil.
    • 23 Aug 2026 · neutral · X ↗
      Notes that taking vitamin D3 with a fat-containing meal resulted in 32% higher peak blood vitamin D levels.
    • 17 Aug 2026 · recommends · X ↗
      Recommends taking Vitamin D in the morning or at lunch with fat.
    • 14 Aug 2026 · neutral · X ↗
      Notes that Boron improves vitamin D.
    • 5 Aug 2026 · recommends · YouTube ↗
      Recommends Vitamin D because microglia contain Vitamin D receptors, and Vitamin D helps keep the immune system properly regulated, with low levels associated with greater neuroinflammation and a higher risk of autoimmune conditions.
    • 27 Jul 2026 · Vitamin E · neutral · YouTube ↗
      Notes that oral vitamin E and C supplementation has been noted to increase the dose of UVB radiation from the sun needed to cause redness of the skin, suggesting increased resilience against sun damage. He also mentions a trial where a combination of slow-release vitamin C and vitamin E decreased the progression of carotid atherosclerosis in men.
    • 9 Jul 2026 · Vitamin E · neutral · YouTube ↗
      Mentions vitamin E in comparison to topical melatonin for oxidative defense, stating that melatonin would compete but is not as broadly validated clinically.
    • 12 Jun 2026 · Vitamin E · recommends · YouTube ↗
      States that the biggest evidence for multivitamin is that it improves cognition and enhances episodic memory in elderly people, who tend to have worse diets and are more likely to be deficient.
    • 24 Apr 2026 · Vitamin E · uses · YouTube ↗
      Created Microvitamin, a supplement that bundled all the supplements he was taking, to help fund his a med trial.
  • Ben Greenfield · Vitamin E · neutral
    • 29 Oct 2026 · neutral · YouTube ↗
      Mentions a recent study showing no significant increase in bleeding for patients on Vitamin E supplementation during open heart surgery, which was interesting for him to learn.
    • 29 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Notes that Vitamin D is actually a hormone and recommends patients aim for levels around 40 to 50, or even 60 for fracture healing, for optimal healing, as opposed to just above 20 which is considered normal.
    • 15 Oct 2026 · Vitamin D · recommends · Podcast ↗
      Mentions vitamin D as part of a bare-minimum protocol.
    • 15 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Advises getting vitamin D levels between 60 and 100 nanograms per milliliter as a minimum step for overall health and to slow down heart disease.
    • 20 Aug 2026 · Vitamin D · uses · YouTube ↗
      Has been taking Vitamin D3 K2 for over a decade.
    • 8 Aug 2026 · Vitamin D · neutral · Instagram ↗
      Notes that sunlight influences more than just vitamin D production.
    • 8 Aug 2026 · Vitamin D · recommends · YouTube ↗
      Recommends keeping vitamin D levels high, suggesting that a supplement is probably not a bad idea, especially given that many people are deficient due to spending most of their time indoors.
    • 18 Jul 2026 · Vitamin D · recommends · YouTube ↗
      Recommends getting enough vitamin D for blood pressure management.
    • 9 Jul 2026 · Vitamin D · recommends · YouTube ↗
      Recommends optimizing vitamin D levels to a serum score of around 50 to 80 nanograms per milliliter, as deficiency is linked to tinnitus volume and can assist with it.
    • 13 Jun 2026 · neutral · X ↗
      Notes a new study indicating that vitamin E is a core dietary antioxidant closely associated with a reduced risk of accelerated biological aging.
    • 13 Jun 2026 · recommends · Podcast ↗
      Recommends Xtendlife's Tocotrienols Vitamin E for cardiovascular, brain, and healthy aging support, noting that research points to tocotrienols over alpha-tocopherol.
    • 7 Jun 2026 · Vitamin D · recommends · Facebook ↗
      Recommends using hormone building blocks like vitamin D for hormone optimization.
    • 6 May 2026 · Vitamin D · neutral · X ↗
      Notes that vitamin D deficiency is the most common deficiency.
    • 22 Nov 2025 · recommends · YouTube ↗
      Recommends whole food vitamin E, explaining that typical supplements only provide alpha-tocopherol, while the whole food complex includes four tocopherols and four tocotrienols, often with selenium at the core.
  • Dr. Mark Hyman · Vitamin D · recommends
    • 26 Oct 2026 · recommends · Facebook ↗
      Recommends Vitamin D for health, stating that amazing things happen when patients' vitamin D statuses reach optimal levels.
    • 21 Oct 2026 · neutral · YouTube ↗
      Mentions vitamin D as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
    • 19 Oct 2026 · neutral · YouTube ↗
      Notes that vitamin D plays a role in immune function.
    • 8 Oct 2026 · recommends · Instagram ↗
      Recommends checking vitamin D levels and states that if they had to pick one single intervention for immune health, vitamin D would be it.
    • 7 Oct 2026 · neutral · Podcast ↗
      Dr. Hyman discusses vitamin D in relation to sun exposure patterns.
    • 7 Oct 2026 · recommends · YouTube ↗
      States that vitamin D supplementation can help with oxidative stress.
    • 5 Oct 2026 · neutral · Podcast ↗
      Mentions vitamin D as a key nutrient for supporting immune function.
    • 5 Oct 2026 · recommends · YouTube ↗
      States that vitamin D is probably the single most important intervention for immune health, recommending levels of 45 to 70 and emphasizing testing to determine the right dose.
    • 30 Sep 2026 · neutral · YouTube ↗
      Notes that rickets, which causes terrible bone deformities, is caused by vitamin D deficiency.
    • 21 Sep 2026 · neutral · YouTube ↗
      Notes that vitamin D is an important nutrient for brain performance and aging, and that many people have gaps in these nutrients.
    • 31 Aug 2026 · Vitamin E · neutral · YouTube ↗
      Notes that patients who were very malnourished had extremely low vitamin E.
    • 18 Apr 2026 · Vitamin E · neutral · Facebook ↗
      Lists Vitamin E as important for cell protection and anti-aging.
    • 1 Apr 2026 · Vitamin E · warns · YouTube ↗
      Recommends avoiding Vitamin E for at least a week before surgery because it can thin the blood.
    • 8 Oct 2025 · Vitamin E · neutral · YouTube ↗
      Notes that Vitamin E levels are low in Parkinson's patients.
  • Thomas DeLauer · Vitamin D · uses
    • 23 Oct 2026 · uses · YouTube ↗
      Uses vitamin D3 in the fall and winter months when getting less sun, as it's important to supplement it then.
    • 20 Oct 2026 · recommends · YouTube ↗
      Recommends taking a massive amount of vitamin D simultaneously with an early morning massive breakfast to help reset circadian rhythms and address hyperphagia.
    • 8 Oct 2026 · recommends · Facebook ↗
      Recommends Vitamin D, stating that it has receptors throughout the brain and deficiency can quickly impact brain and mood.
    • 6 Oct 2026 · uses · YouTube ↗
      Takes supplemental vitamin D because he is skin sensitive and from northern latitudes, limiting his UV exposure.
    • 5 Oct 2026 · recommends · YouTube ↗
      Recommends taking vitamin D on non-liver days to ensure both nutrients get proper receptor access.
    • 29 Sep 2026 · uses · YouTube ↗
      Takes Purity's liquid vitamin D3 with K2 because she is constantly inside during the day; D3 is for overall wellness and K2 helps the body absorb calcium properly.
    • 11 Sep 2026 · recommends · YouTube ↗
      Recommends getting vitamin D, suggesting it can be obtained while walking.
    • 6 Sep 2026 · recommends · Instagram ↗
      States that vitamin D is best obtained from the sun, but getting it from food definitely helps, and notes its role as a hormone influencing many cells.
    • 1 Sep 2026 · recommends · Instagram ↗
      Recommends D3, suggesting a dose of 2000-4000 IU, and notes that MK-7 slowed bone loss over three years.
    • 25 Aug 2026 · Vitamin E · neutral · YouTube ↗
      Mentions a causal link found between vitamin E and waking up in the middle of the night.
    • 24 Aug 2026 · recommends · YouTube ↗
      Recommends vitamin D, especially for Hashimoto's, explaining that it drives T reg expansion to suppress autoimmune responses that attack the thyroid, and notes that vitamin D and selenium deficiencies often co-occur.
    • 29 Jul 2026 · Vitamin E · recommends · YouTube ↗
      Recommends using a multivitamin to ensure adequate micronutrient intake, especially when wholesome food is less available.
    • 9 Jul 2026 · Vitamin E · warns · YouTube ↗
      Advises checking multivitamins because many contain 100, 200, or 300% of the daily value of selenium, which can contribute to excessive intake.
    • 26 Jun 2026 · Vitamin E · recommends · YouTube ↗
      Recommends vitamin E for protecting skin cell membranes, reducing oxidative stress, and preventing lipid damage, especially for those with high stress and low dietary intake.
  • Bryan Johnson · Vitamin D · uses
    • 22 Oct 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 15 Aug 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 3 Jul 2026 · neutral · X ↗
      Mentions that the sunlight assessment claims low vitamin D levels cause the immune system to misfire, and notes that their vitamin D has been measured.
    • 4 May 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for longevity.
    • 2 May 2026 · uses · X ↗
      He takes 5000 IU of Vitamin D3 in the morning for general health.
    • 21 Apr 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 15 Apr 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning for longevity.
    • 14 Apr 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning.
    • 8 Apr 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning.
    • 7 Apr 2026 · uses · X ↗
      He takes 5000 IU of Vitamin D3 in the morning for general health.
    • Date not recorded · Vitamin E · recommends · Website ↗
      Recommends adequate Vitamin E for hair health, noting it is in the Blueprint stack.
    • Date not recorded · Vitamin E · uses · Website ↗
      Uses Vitamin E at 10 IU/ML in his custom topical hair formulation.
  • Dr. Rhonda Patrick · Vitamin D · neutral
    • 5 Oct 2026 · neutral · Facebook ↗
      Vitamin D supplementation was linked to a 40% lower risk of dementia in an observational study of more than 12,000 older adults.
    • 30 Sep 2026 · recommends · YouTube ↗
      Mentions that vitamin D also plays a role in maintaining muscle mass.
    • 28 Sep 2026 · recommends · YouTube ↗
      Recommends ensuring adequate vitamin D intake for men's sperm health.
    • 24 Sep 2026 · neutral · Facebook ↗
      Vitamin D and strength training alone did not, but adding them strengthened the effect on one clock, with the full combination slowing that measure by ~3.8 months.
    • 25 Aug 2026 · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 25 Aug 2026 · Vitamin E · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 28 Jul 2026 · recommends · Facebook ↗
      Recommends Vitamin D, noting it regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity, and correcting deficiency may slow epigenetic aging.
    • 22 Jul 2026 · neutral · YouTube ↗
      Uses Vitamin D3 as an example of a supplement that an AI model could track to see its impact on other metrics like glucose levels.
    • 26 Jun 2026 · recommends · Facebook ↗
      Recommends Vitamin D, explaining that it regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity.
    • 15 Jun 2026 · neutral · Instagram ↗
      Combining omega-3s with vitamin D and exercise has an additive effect, translating to ~3 months of slowed biological aging.
    • 11 Jun 2026 · neutral · Facebook ↗
      The effect got stronger when omega-3 was combined with vitamin D and resistance training, with the full stack delaying phenotypic aging by about 3.8 months.
    • 5 Feb 2026 · Vitamin E · recommends · Facebook ↗
      Choosing a multivitamin that includes lutein and zeaxanthin ensures you get meaningful amounts every day.
    • 9 Jan 2026 · Vitamin E · neutral · Facebook ↗
      Notes that ~60% of Americans are low in vitamin E.
    • 9 Sep 2025 · Vitamin E · warns · YouTube ↗
      Suggests avoiding a multivitamin if it contains biotin before a testosterone blood test to prevent confounding results.
  • Andrew Huberman · Vitamin D · neutral
    • 21 Sep 2026 · neutral · YouTube ↗
      Notes that most people are probably deficient in vitamin D and benefit from supplementing, but there's no point in doing it unless you're deficient for most things.
    • 7 Aug 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning for longevity.
    • 20 Jul 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 20 Jul 2026 · recommends · YouTube ↗
      States that Vitamin D is one of the critical nutrients with the best evidence for cognitive function and reducing the risk of dementia.
    • 13 Jul 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning.
    • 12 Jul 2026 · uses · X ↗
      He takes 5,000 IU of Vitamin D3 in the morning for overall health.
    • 6 Jul 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning.
    • 22 Jun 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning for general health.
    • 17 Jun 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 every day for longevity.
    • 17 Jun 2026 · Vitamin E · uses · X ↗
      Takes a multivitamin every day for longevity.
    • 6 Jun 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning.
    • 24 Feb 2025 · Vitamin E · warns · YouTube ↗
      Warns that high-dose supplementation of Vitamin E, when given to lung cancer patients, led to worse outcomes than control subjects, highlighting that it's not the same as ingesting it in food.
    • 26 Jun 2023 · Vitamin E · recommends · YouTube ↗
      Recommends Vitamin E as part of the AREDS2 supplementation for slowing the progression of dry macular degeneration.
    • 15 Feb 2023 · Vitamin E · warns · YouTube ↗
      Mentions evidence suggesting that a combination of vitamin C and vitamin E can blunt hypertrophic adaptations because they are anti-inflammatory antioxidants.
  • Peter Attia · Vitamin D · uses
    • 4 Jan 2026 · uses · YouTube ↗
      Lists vitamin D as one of her staple supplements.
    • 16 Nov 2025 · neutral · YouTube ↗
      Notes that several studies show patients taking vitamin D can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
    • 6 Aug 2025 · neutral · YouTube ↗
      States that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin D for both sexes.
    • 3 Aug 2025 · neutral · YouTube ↗
      Uses vitamin D as an example of how people might dismiss its efficacy due to failed clinical trials that didn't adjust the dose or measure levels.
    • 20 Jul 2025 · neutral · YouTube ↗
      In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin D for both sexes.
    • 10 Jul 2025 · neutral · YouTube ↗
      Suggests that supplementing with lots of vitamin D might help overcome the negative effects of phenytoin on bone health by improving calcium absorption, though he is unaware of studies on this.
    • 9 Jul 2025 · recommends · YouTube ↗
      Recommends Vitamin D3 as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 800 to 1,000 IU, which can be obtained through sunlight or supplementation.
    • 6 Jul 2025 · neutral · YouTube ↗
      Suggests that supplementing with lots of vitamin D might overcome the negative effects of phenytoin on bone health by counteracting increased catabolism of vitamin D and subsequent decreased calcium absorption.
    • 8 Jun 2025 · recommends · YouTube ↗
      Recommends vitamin D for people who tend to be vitamin D deficient, such as those living in Portland, Oregon.
    • 17 Mar 2025 · neutral · Instagram ↗
      Discusses evaluating vitamin D, understanding deficiency, and optimal levels.
    • 20 May 2024 · Vitamin E · warns · YouTube ↗
      Notes that there are some downsides to Vitamin E, including cardiovascular longitudinal risk and prostate cancer, and that discussions are needed with patients, especially those with diabetes or cirrhosis, due to studies indicating increased all-cause mortality depending on the dose.
    • 2 Jul 2023 · Vitamin E · warns · YouTube ↗
      Peter Attia, involved in the American Urological Association Peyronie's guidelines, stated that vitamin E is not indicated for Peyronie's disease and should not be given.
    • 26 Jun 2023 · Vitamin E · warns · YouTube ↗
      States that American Urological Association guidelines advise against giving vitamin E for Peyronie's disease as it is not indicated.
    • 6 Feb 2020 · Vitamin E · neutral · YouTube ↗
      Suggests that taking vitamin E would almost assuredly not be required if one eats a balanced diet.

RAL Summary

Members OnlyTier 4 for Bone Health

The rules set tier 5 (does not work), but the vitamin D studies are mixed rather than negative: one large review found 700 to 800 units a day cut hip and other fractures, while others found no fracture benefit. So it is graded Tier 4, as the studies disagree.

  • Emerging: not enough evidence to rank higher yet.

Where the evidence disagrees: 3 of the 13 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Skeletal system, Endocrine system

Combine with: For bone health, pair vitamin D3 with vitamin K2 (MK-7) to help direct calcium into bone rather than soft tissues, and with magnesium (glycinate or citrate), which is needed to activate vitamin D. Calcium from diet or a supplement can be added if intake is low. Take it with a fat-containing meal for better absorption. If your actual goal is blood sugar support, consider adding berberine, chromium picolinate, alpha-lipoic acid, or cinnamon extract alongside it, and for heart support consider omega-3 fish oil and CoQ10. Ask your clinician to check your 25-OH vitamin D level to guide dosing, and consult them before combining supplements with diabetes or heart medications.

Possible side effects: No major side effects reported.

Supplement Facts

Vitamin D 25 mcg
Supplement Facts
Serving Size 2 Drop(s)
Servings Per Container 600
Amount Per Serving% Daily Value
Vitamin D25 mcg

Other ingredients: Medium Chain Triglyceride Oil, Mixed Tocopherols.

Directions: Suggested use: Take 2 drops one to three times daily or as recommended by your health-care practitioner. Invert bottle to dispense individual drops. May be added to food or mixed in beverages.

Barcode (UPC) 693749168010 · Label source: NIH label database · Report a label change

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Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.