Thorne Zinc Bisglycinate 30 mg Review
Thorne's Zinc Bisglycinate 30 mg is presented as a well-absorbed form of zinc that supports general health, from immune function to reproductive health. The product page states that Zinc Bisglycinate helps to support optimal wellness, promotes healthy connective tissue and skin repair, and helps maintain eye and reproductive health. Each bottle contains 60 capsules, and the listed serving size is one capsule. Each capsule lists 30 mg of zinc from Zinc (Bisglycinate Chelate). The page describes zinc as an essential micronutrient that plays a key role in growth and development, immune function, and testosterone metabolism, and as the second-most abundant mineral in the body after iron. It says clinical studies demonstrate that zinc supplementation can increase general wellness and has a beneficial impact on connective tissue, as well as reproductive and eye health. According to the page, zinc bisglycinate is absorbed intact and does not compete with other minerals for absorption in the intestinal tract. A cross-over study cited on the page reported 43 percent higher zinc blood levels with the bisglycinate form compared to zinc gluconate. The page explains that zinc bisglycinate is zinc bound to two molecules of the amino acid glycine, which it describes as a calming neurotransmitter that supports relaxation and promotes the body's production of glutathione. The benefits listed include support for the development and function of immune system cells, help maintaining T-cell activation, antioxidant properties that help the body mitigate oxidative stress, support for skin and eye health, support for normal testosterone production, and prostate health support in men age 50 and older, who may benefit from a higher dose of zinc. The page suggests it may benefit men over 50, older individuals focused on eye health, people wanting to enhance skin health, and athletes with high sweat output because zinc is lost in sweat. Features noted are availability in both 15 mg and 30 mg doses and a chelated form for optimal absorption. The page states the product has been third-party tested and certified to verify that contents match the label and contain no unsafe levels of contaminants such as heavy metals, pesticides, and microorganisms. Warnings state the product is contraindicated for individuals with a history of hypersensitivity to any ingredient, that pregnant users should consult a health-care practitioner first, and that zinc can inhibit copper absorption, so long-term use should include copper at a 15:1 zinc to copper ratio. The price shown is $20 for 60 capsules, or $18 with a subscription.
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Study, Trial or Testing Result Summary
Members Only17 human studies · 6 improved
This capsule gives 30 mg of zinc a day, above the 10 mg that worked in studies. The best evidence comes from large reviews of colds. A 2024 review of 34 trials with 8526 children and adults found zinc made little or no difference to catching a cold. Taken once a cold started, it may have shortened colds by about 2.4 days, with more mild side effects [1]. A 2021 review in adults found no drop in respiratory infections but symptoms that lasted about 47 percent less time [2]. A 2020 review in healthy adults found zinc did not prevent colds but may have shortened them by about 2.25 days [3]. An older review of zinc lozenges found no clear benefit at 7 days [4]. In 826 preschool children, 10 mg daily for 4 months cut infection days by 12 percent, which was not significant, and by 20 percent after vitamin A was given [5]. In 80 adults, a zinc nasal gel shortened colds to a median of 4.3 days, compared with 6 days on placebo [6]. Some of the benefit comes from lozenges and nasal gel used during a cold, not from a daily capsule. Overall, zinc does not seem to prevent colds but may shorten them. Animal and cell studies are never counted.
See all 17 studies →Hide the studies
- Across 34 trials with 8526 children and adults, zinc made little or no difference to catching a cold but may have shortened colds by about 2.4 days when used as treatment, with more mild side effects.Zinc for prevention and treatment of the common cold.
- In adults, zinc did not reduce the risk of respiratory infections but shortened symptom duration by about 47 percent.Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic revie…
- In children with pneumonia, zinc may have slightly shortened hospital stays but did not speed recovery time, and no nutritional supplement could be recommended for routine treatment.A systematic review and meta-analysis on nutritional and dietary interventions for the treatment of acute respiratory in…
- Pooling 6 trials of adults with colds, zinc lozenges did not significantly reduce the chance of having cold symptoms at 7 days.A meta-analysis of zinc salts lozenges and the common cold.
- This review of common cold treatments covered zinc gel and lozenges among other options, but the abstract gives no results for zinc.Common cold.
- This review of common cold treatments covered zinc gel and lozenges among other options, but the abstract gives no results for zinc.Common cold.
- In healthy adults, zinc did not prevent colds but may have shortened colds by about 2.25 days when given alone.Zinc Supplementation Reduces Common Cold Duration among Healthy Adults: A Systematic Review of Randomized Controlled Tri…
- In 826 Indonesian preschool children given 10 mg zinc daily for 4 months, days with upper respiratory infection fell 12 percent (not significant), and 20 percent after vitamin A was given.Zinc combined with vitamin A reduces upper respiratory tract infection morbidity in a randomised trial in preschool chil…
- In 80 healthy adults with a new common cold, zinc gluconate nasal gel used four times daily until symptoms resolved (up to 10 days) shortened cold duration to a median of 4.3 days versus 6 days with placebo.Effect of zincum gluconicum nasal gel on the duration and symptom severity of the common cold in otherwise healthy adult…
- In 40 Air Force Academy cadets taking 15 mg of zinc gluconate daily for seven months, self-reported symptom-free episodes were significantly higher than with placebo, but doctor-diagnosed upper respiratory infections did not differ.Use of zinc supplements to reduce upper respiratory infections in United States Air Force Academy cadets.
- In 8 healthy men, a 10-week low-zinc diet (4.6 mg a day) reduced immune cell proliferation, which stayed reduced after 5 weeks of 9.1 mg zinc a day, while immune cell numbers and several other immune measures did not change.Immune functions are maintained in healthy men with low zinc intake.
- In 37 patients with skin infections called phlegmons, those given zinc tablets after low serum zinc was found had no further lesions for more than 10 months, though the study was uncontrolled.Serum zinc levels in patients with phlegmons as a marker of the severity of infection and the potential of zinc suppleme…
- Young vegetarians and vegans had more zinc deficiency than omnivores, and this deficiency was linked to lower interleukin-2 production and weaker immune function.Reduced interleukin-2 production and increased CREMα protein expression in vegetarians and vegans due to zinc deficiency…
- In 19 hemodialysis patients given influenza vaccine, 4 weeks of zinc acetate (60 mg elemental zinc daily) did not increase antibody responsiveness to the vaccine.Influenza vaccination in chronic hemodialysis patients. The effect of zinc supplementation.
- In 19 healthy older adults, moderate zinc supplementation reduced spontaneous inflammatory cytokine release and improved T cell response to stimulation.Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions.
- In 6 patients with acrodermatitis enteropathica, low zinc levels were linked to weaker T and B cell responses, and these normalized when zinc levels recovered with supplementation.Abnormal immune responses during hypozincaemia in acrodermatitis enteropathica.
- In volunteers with experimentally produced colds, zinc gluconate removed the drop in choice reaction time seen during the cold.Effects of zinc gluconate and nedocromil sodium on performance deficits produced by the common cold.
Review Totals and Summary
Members Only6,271 reviews · 97% positive
Across the stores, Thorne Zinc Bisglycinate 30 mg carries about 3,453 ratings and is mostly well liked. Buyers lean heavily on trust in the brand and report few problems, though the written feedback is short and light on detail. (Reviews of other forms of this product were left out; this covers the capsules only.) **What buyers say it did for them:** Written comments are brief on results. One buyer says it "works well, use it for sleep," and another takes zinc with D3 and magnesium to support immunity and bones. Store summaries add more: Vitacost reviewers mention stronger nails, somewhat easier painful periods, and benefits for hair, skin and immunity. A husband is described as more energized and balanced. iHerb's page summary mentions alertness, energy, digestion and fertility support, and Thorne.com's mentions connective tissue and skin repair. These are buyers' own impressions, not clinical findings. **What they complain about:** Complaints are rare. One buyer says, "This made me nauseated," and asks how to take it. An iHerb reviewer likewise felt queasy on an empty stomach and now takes it at night before bed. Another reviewer reports "Expensive product, and I didn't receive it," which is a delivery problem rather than a product one. No store summary reports problems with taste, shipping or effectiveness. **Taste, smell, pill size and form:** Capsules are described as small and easy to swallow, which comes from the Vitacost and iHerb summaries. iHerb buyers also note no aftertaste. One reviewer calls the pills "very small but pack a punch," according to the iHerb summary, and another with a digestive condition finds the capsule easier to process than veggie caps. Vitacost mentions easy use with no stomach discomfort. The 30 mg dose is called perfect by a few reviewers, and one stacks it with the 15 mg version when needing more. **Value for money:** There is little on value. The only price remark is the one-star "Expensive product," and it is tied to a failed delivery. Otherwise, buyers who praise quality seem satisfied with what they get, but the reviews give no price comparisons. **Who it seems to suit and who it did not:** The strongest fit is people who already trust Thorne. One says it is "the only supplement brand that I trust," and another says, "recommended by my doctor." It also suits those wanting a small capsule and simple ingredients, and people taking it daily for immunity, skin, hair or nails. Those with sensitive stomachs may find it harder; the nausea reports came from taking it without food, and one buyer found bedtime worked better. The Thorne.com summary notes that the page gives no specific guidance on timing or taking it with food beyond its copper warning. iHerb's Q&A suggests spacing zinc two hours from copper, iron or phosphorus supplements. **A caution on the evidence:** Many written reviews are a single line, and the visible samples are small compared with the star counts. Of the star-rated reviews, 83% give four or five stars. Walmart's histogram shows 85% five stars and 3% one star, and Vitacost shows 4.8 out of 5 across 241 ratings.
Biohacker Summary
Members Only10 of 10 recommend it
All ten panelists spoke about zinc, and the group leans toward recommending or using it, with four recommending it and the rest saying they use it or take it as part of a routine. The most common reasons are immune support and testosterone and sperm health, with several noting the benefit mostly applies to people who are low in zinc, and others pointing to wound healing, gut lining, mood, and hair. On forms, one panelist uses zinc carnosine for the gut, and one mentions lozenges for an early cold. Doses named include 15 mg each morning, 30 mg for sperm health, 40 to 60 mg a day for viral defense, and a surgery routine for wound healing. Zinc is paired with vitamin C for immunity and with creatine, and one panelist says to get enough zinc before trying peptides. One panelist notes that birth control pills deplete zinc, and no one said they stopped taking it.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Zinc · recommends
- Recommends ensuring sufficient zinc intake because the prostate needs enough zinc for the conversion from testosterone to DHT to be smooth and optimized.
- Recommends taking zinc carnosine for an ulcer or some type of gastric problem.
- Emphasizes the importance of zinc for decreasing viral replication and recommends taking 40 to 60 mg every single day.
- Notes that birth control pills deplete the body of zinc, which is needed for the brain to make serotonin.
- Added zinc to his creatine product because a deficiency in zinc might make creatine not work as well.
- Mentions that grass-fed liver is loaded with zinc.
- Recommends zinc to enhance testosterone.
- Highly recommends taking at least 50 mg of zinc at the first sign of a cold.
- Recommends a new product called black elderberry with added zinc and vitamin D, which combines four essential immune support nutrients, and advises taking three per day with meals.
- Recommends ensuring enough zinc intake because vitamin A, which can help with dry mouth, doesn't work without it.
Andrew Huberman · Zinc · uses
- Zinc carnosine to support and improve the lining of your gut.
- Notes that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
- States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
- Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
- States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut, and he was already taking some of these ingredients separately.
- States that AG1 Pro includes zinc carnosine, which he was already taking separately, to support and improve the lining of the gut.
- Personally takes zinc carnosine, which is included in AG1 Pro to support and improve the lining of the gut.
- AG1 Pro has zinc carnosine to support and improve the lining of your gut. Some of these ingredients I personally was already taking separate from the AG1 formula.
- States that AG1 Pro contains zinc carnosine to support and improve the lining of your gut.
- Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
Ben Greenfield · Zinc · warns
- Ben Greenfield's formulation includes 30 grams of zinc a day, taken for one week before surgery and two weeks after, as it is an important cofactor for wound healing.
- Emphasizes that zinc sufficiency is crucial for immunity because the thymus-derived peptide thymulin, which trains lymphocytes, requires zinc to be active.
- Recommends adding zinc into one's stack because it is a co-factor for enzymes involved in testosterone synthesis and sperm maturation, and zinc deficiency is a reproducible cause of low sperm count.
- He mentions zinc as a supplement with real human data behind it for male fertility.
- Zinc may support both testosterone and sperm count.
- Warns that he was taking so much zinc without realizing it because it was in five different things he was taking, and he couldn't pinpoint the problem.
- Recommends supplementing with zinc if deficient, as multiple trials show significant symptom reduction of tinnitus in zinc-deficient individuals.
- Notes a new study indicating that zinc is a core dietary antioxidant closely associated with a reduced risk of accelerated biological aging.
- Recommends using hormone building blocks like zinc for hormone optimization.
- Advises taking the GI Repair Formula away from food for best results, unless zinc causes nausea.
Thomas DeLauer · Zinc · uses
- Adds zinc to their immunity duo because it helps them absorb vitamin C, considering the two together a fantastic combination for fall and winter.
- Recommends zinc, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
- Mentions that more zinc could be beneficial for testosterone, but it's not working on the axis that most people need help with.
- Compares zinc content, noting salmon has under 1mg while oysters have 74mg per 100g, a 70x difference.
- Recommends keeping zinc levels topped off because it is a critical cofactor for over 300 enzymes and is important for immune cells, testosterone, and wound healing.
- Recommends 15 mg of supplemental zinc if oysters are not realistic, but emphasizes that food source zinc is better as it comes with natural cofactors like copper and selenium.
- Recommends getting zinc, along with vitamin D, magnesium, and calcium, from foods like sardines, as they are important for inflammatory pathways in the gut.
- Explains that zinc is a structural cofactor for an enzyme crucial in testosterone production, and a marginal deficiency is a reversible cause of suppressed testosterone. He recommends getting zinc through pumpkin seeds.
- Explains that zinc is a required cofactor for the 5-alpha reductase enzyme, which converts testosterone into its more potent form, DHT, and that zinc deficiency can impair this conversion.
- Recommends ensuring adequate zinc intake for skin healing and immune response, especially for heavy sweaters or those consuming high phytate foods.
Dave Asprey · Zinc · uses
- Developed a nonnano zinc sunscreen over five years, stating her skin is probably better now than it's ever been.
- Emphasizes the importance of having enough zinc before trying advanced longevity strategies like peptides.
- Suggests that zinc has better safety and protective data than meds for reducing cardio respiratory risk.
- Advises that if someone has a goal, they should probably do simple things like getting more zinc if it helps their goal before using peptides.
- Recommends zinc for muscle and bone formation, stating that without it, the body cannot effectively build muscle and bone even with exercise and protein intake.
- Dave Asprey mentions zinc as a supplement and cofactor that supports thyroid activation.
- Recommends zinc as a cofactor that can help thyroid function, especially with conversion issues.
- Argues that if you are lacking zinc, ESS60 will not work as well.
- Recommends adequate zinc for healthy DHT signaling.
- States that he genetically needs a ton of zinc for his mitochondria to work, and if he doesn't take enough, his mitochondria don't work.
Dr. Mark Hyman · Zinc · uses
- Gave a patient with psoriatic arthritis a little zinc, which contributed to significant improvement in her condition.
- Recommends ensuring adequate zinc intake on a regular basis for immune support, noting some data on zinc lozenges for early cold.
- Recommends correcting nutrient deficiencies with zinc.
- Recommends nutrient-dense foods rich in zinc, such as pumpkin seeds and oysters, to reduce inflammation.
- Used zinc as part of a protocol to rebuild the gut microbiome and heal the gut of a nine-year-old girl with severe behavioral issues.
- Notes that zinc supports immune health, helps wounds heal, and plays a key role in growth and tissue repair, and they measure it.
- Mentions zinc is needed for phase one liver functions and inflammation.
- Notes that birth control drains zinc.
- Recommends zinc for immune system support and modulation.
- Relies on Big Bold Health's HTB Immune Energy Chews, which deliver 1000mg of sprouted Himalayan tardy buckwheat, along with vitamin C, D, magnesium, and zinc, to support immune balance, resilience, energy, and focus.
Dr. Rhonda Patrick · Zinc · recommends
- Notes that not getting enough zinc can affect testosterone, as zinc is very important for testosterone synthesis.
- Recommends men take a 30 milligram zinc supplement for sperm health when preparing for IVF.
- Discusses findings from a meta-analysis on zinc supplementation, noting it improved insulin resistance, inflammation, and oxidative stress in people with diabetes or prediabetes, and explains its biological role in the pancreas.
- Recommends nutrients like zinc for men to prioritize sperm mitochondrial health.
- Recommends Zinc, stating it is a critical mineral required for testosterone production and that supplementation corrects deficiency-related low testosterone.
- Recommends correcting deficiencies in zinc to directly increase total testosterone by up to 100+ ng/dL.
- Recommends focusing on zinc to optimize testosterone and hormone health generally, noting that it supports luteinizing hormone production, which stimulates testosterone synthesis and conversion to dihydrotestosterone.
- Recommends zinc as one of the most reliable natural supplements for boosting testosterone if one is deficient, noting it's part of the ZMA combination.
- Recommends increasing intake of zinc if one regularly drinks alcohol.
- States that zinc is crucial for alcohol metabolism and that higher intakes might correlate with less severe hangover symptoms, also noting that alcohol increases zinc excretion, so replenishing zinc stores while consuming alcohol is important.
Siim Land · Zinc · recommends
- States that deficiencies in nutrients such as zinc can impair normal immune regulation.
- Explains that zinc raises testosterone only if zinc status or testosterone levels are low, and can reduce the duration and severity of colds and flu, and lower blood sugar and lipids if zinc status is low.
- States that fixing zinc deficiency can double testosterone if low testosterone is due to zinc deficiency.
- States that zinc has strong evidence for increasing testosterone, but only if one has low zinc status.
- States that zinc deficiency is observed in children with premature graying of hair.
- Warns that supplementing 250 mg of zinc sulfate, which provides 55 to 60 mg of elemental zinc, is above the tolerable upper limit and can cause side effects like reduced copper absorption, anemia, immune dysfunction, GI stress, abdominal pain, diarrhea, and a metallic taste.
- States that zinc helps with immunity, wound healing, and testosterone levels, acknowledging its importance as a mineral and placing it in the 'good tier' despite not personally finding much value from it.
- Used to take zinc in the past but no longer does, as he has already tested most supplements.
- Recommends Zinc, acknowledging its importance as a mineral for immunity, wound healing, and testosterone levels, especially for those with low zinc.
- Discusses Zinc as a supplement.
Bryan Johnson · Zinc · uses
- Takes 15 mg of Zinc in the morning for longevity.
- Takes 15 mg of Zinc in the morning.
- Takes 15 mg of Zinc in the morning for longevity.
- Bryan Johnson's baseline measurements showed low zinc, which was easy to fix by adjusting her protocol and supplements.
- Recommends adequate Zinc for hair health, noting it is in the Blueprint stack.
Peter Attia · Zinc · recommends
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Discusses the AREDS formula, which initially included C and beta-carotene with zinc and copper, and later replaced beta-carotene with lutein and zeaxanthin, showing it could delay or reduce the conversion of mild to severe macular degeneration.
- Explains that for Wilson's syndrome, which can lead to liver failure, the treatment given to children is zinc, which is inexpensive and effective in outcompeting copper to prevent overload.
- Uses a new irrigant called ZinC and Gent because they are very worried about prosthetic infection.
- Discusses the AREDS formula, which includes C, E, beta-carotene, zinc, and copper, and later lutein and zeaxanthin instead of beta-carotene. Studies showed it could delay or reduce the conversion of mild to severe macular degeneration but had no effect on severe disease or preventing it in healthy individuals.
- Mentions that a survey of doctors showed they recommend Zinc for COVID-19, but notes there is no real evidence behind it.
- Mentions zinc pyrithione as a treatment protocol for dandruff, which addresses malassezia yeast overgrowth in the scalp.
RAL Summary
Members OnlyTier 4 for Immune Health
The rules graded zinc as not working, but three large reviews found it shortened colds by about two days even though it did not prevent them, so the studies give some support rather than showing no effect. So it is graded Tier 4, as the studies disagree.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 4 of the 17 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Immune system, Respiratory system, Digestive system
Combine with: For immune support, zinc pairs well with vitamin C, vitamin D3 with K2, and elderberry or quercetin, which may improve zinc uptake into cells. If using it long-term at 30 mg, add copper (about 1-2 mg) because zinc can deplete copper over time. For women's hormone goals, consider stacking with magnesium glycinate, vitamin B6 (P5P), and omega-3s for cycle and PMS support, DIM or calcium-D-glucarate for estrogen metabolism, and myo-inositol for PCOS-related concerns. Take zinc with food to reduce nausea and separate it from iron and calcium supplements by a couple of hours. Consult a clinician before long-term use of high doses.
Possible side effects: Studies note more mild side effects with zinc treatment. Some buyers felt nauseated when taking it on an empty stomach, which eased when taken with food or at bedtime.
Supplement Facts
Zinc 30 mg
| Zinc | 30 mg |
Other ingredients: Microcrystalline Cellulose, Hypromellose, Leucine, Silicon Dioxide.
Directions: Suggested use: Take 1 capsule daily or as recommended by your health-care practitioner.
Barcode (UPC) 693749011743 · Label source: NIH label database · Report a label change
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Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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