Universal Natural Sterol Complex Review
Universal Nutrition Natural Sterol Complex Tablets, 180 Ct is listed on Walmart under the brand Universal Nutrition. The page title is Universal Nutrition Natural Sterol Complex Tablets, 180 Ct, and the brand name links to the Universal Nutrition brand page. The key item features section reads: Universal Natural Sterol Complex Tablets. Designed for serious training programs. Mass and density enhancer. Contains a comprehensive formulation of the most powerful phytonutrients. Increase Peak Performance. Advanced Ultra-Concentrated Formula. The size option shown is 180 Tablets at $32.99, and the listing is marked out of stock. The page shows the current price as USD$32.99 under the label Price when purchased online. Shipping, pickup, and delivery are all shown as unavailable, and the page offers a notify me option for when the item is back in stock. The product rating is 4.8 out of 5 stars from 5 ratings, with 5 reviews listed. The sections titled About this item, Product details, Indications, Directions, Warranty, Ingredients, and Warnings appear as headings but contain no text in the scraped content, so this page does not supply an ingredient list, directions for use, indications, warnings, or a serving count. Because the servings per container and daily serving size are not stated, no monthly cost can be calculated from this page. The page also includes thumbnail and hero images of the bottle. Related search links point to sterols, pyroglutamic acid supplements, indole carbinol supplements, glycine, NAC supplements, beta carotene, lycopene, selenium supplements, blood pressure support, and Thorne. Several sponsored and recommended listings appear further down the page for unrelated products, including an Optimum Nutrition creatine capsule product, Nature Made vitamin D and L-lysine products, NOW Supplements NAC, a Nature Made GLP-1 companion pack, a Natrol magnesium glycinate product, an Equate immune support effervescent tablet, a Nature Made Super C product, and a Moducare plant sterol chewable tablet. The Moducare listing is a different brand and product and is not the Universal item described on this page.
Tier ⓘ
Tier 4 · Rank 5
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 5 within Tier 4 for Cholesterol; 36 of 43 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
41 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
100% of 23
Biohacker Mentions
0 of 10
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Study, Trial or Testing Result Summary
Members Only131 human studies · 74 improved
131 human studies74 improved24 no effect757,908 people studied
The main ingredient for cholesterol is the plant sterol complex. Plant sterols and stanols reliably lower bad and total cholesterol in people. A large pooled analysis of 131 trials with 13,062 adults found they lowered both more than placebo [1]. Another analysis of 124 studies found about 0.6 to 3.3 grams a day cut bad cholesterol by about 6 to 12 percent, with bigger effects up to about 3 grams [2]. In one trial, 1.5 grams a day in milk for 3 weeks lowered bad cholesterol by about 9.5 percent [3]. Benefits were also seen in people with inherited high cholesterol [4]. However, on this label the 2000 milligram sterol complex is a blend that also holds tribulus, kudzu and other herbs, so the actual amount of plant sterols is hidden and may be below the studied dose. The plant nutrient blend did not lower cholesterol in trials of similar products [5]. The fatty acid blend comes from flaxseed and lecithin, while the omega-3 studies mostly lowered blood fats called triglycerides with little effect on bad cholesterol [6]. The two remaining blends have no human studies for this goal. Animal and cell studies are never counted.
See all 131 studies →Hide the studies
- In 86 trials of 162,796 adults followed 1 to 7 years, extra omega-3 lowered triglycerides by about 15% but had little or no effect on other blood fats, while slightly reducing heart disease events.Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.
- In a pooled analysis of 19 studies in people with and without chronic lung disease, LDL cholesterol was higher in the group given polyunsaturated fat supplements than in the control group.The association between polyunsaturated fatty acids and chronic obstructive pulmonary disease: a meta-analysis.
- In 79 trials of 112,059 adults lasting at least a year, omega-3 slightly lowered triglycerides and raised HDL but made no clear difference to other blood fats or heart outcomes.Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.
- In 49 trials of 24,272 adults followed 1 to 8 years, more polyunsaturated fat slightly lowered total cholesterol and triglycerides but did not change HDL or LDL cholesterol, and caused slight weight gain.Polyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease.
- In 49 trials of 24,272 adults followed 1 to 8 years, more polyunsaturated fat lowered triglycerides by about 15% but had little or no effect on total cholesterol, HDL or LDL cholesterol.Polyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease.
- Across 131 trials with 13,062 adults, plant sterols and stanols lowered LDL and total cholesterol more than placebo or no treatment, though bergamot and red yeast rice worked best.A network meta-analysis on the comparative effect of nutraceuticals on lipid profile in adults.
- Across 17 studies of 11182 people, blood levels of plant sterols were not linked to risk of cardiovascular disease.Plant sterols and cardiovascular disease: a systematic review and meta-analysis.
- A genetic study of up to 9758 people found that higher blood levels of the plant sterol sitosterol were linked to higher risk of coronary artery disease, partly through cholesterol.Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis.
- In 23 trials, plant sterols and stanols at about 3.4 g a day lowered LDL cholesterol by 11% versus 2.3% with placebo, a smaller drop than policosanol, and were well tolerated.Meta-analysis of natural therapies for hyperlipidemia: plant sterols and stanols versus policosanol.
- In 42 trials of 3,063 older adults with sarcopenia, anti-inflammatory supplements were studied for muscle outcomes; cholesterol results were not reported for omega-3 in the summary, so no cholesterol effect was shown.Foods rich in anti-inflammatory components and anti-inflammatory supplements for the prevention and treatment of Sarcope…
- In 21 trials of about 1,950 adults with metabolic syndrome features, marine omega-3 cut triglycerides substantially, most at over 2,000 mg a day, but LDL cholesterol rose, especially at low doses.Marine-Based Omega-3 Fatty Acids and Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled …
- In 28 trials with 1,777 adults, phytosterols lowered total cholesterol, LDL cholesterol and apolipoprotein B and raised HDL cholesterol, with bigger effects at higher doses.Effects of phytosterol supplementation on lipid profiles and apolipoproteins: A meta-analysis of randomized controlled t…
- In 24 trials of 1,533 people with type 2 diabetes, omega-3 lowered triglycerides by 7% but raised LDL cholesterol by 3% and did not change HDL cholesterol.Potential impact of omega-3 treatment on cardiovascular disease in type 2 diabetes.
- In 20 trials with 1,308 people, phytosterol-enriched foods lowered LDL cholesterol by about 14.3 mg/dL but did not significantly change the inflammation marker CRP.Effects of phytosterols on markers of inflammation: A systematic review and meta-analysis.
- In 23 trials of 1,075 people with type 2 diabetes, about 3.5 g a day of omega-3 for roughly 9 weeks lowered triglycerides and VLDL cholesterol, slightly raised LDL cholesterol, and did not change total or HDL cholesterol.Omega-3 polyunsaturated fatty acids (PUFA) for type 2 diabetes mellitus.
- Across nine trials of 578 people with HIV, omega-3 fats lowered triglycerides and raised HDL (good) cholesterol, but did not change total cholesterol, LDL cholesterol or apolipoprotein levels.Effect of Omega-3 Polyunsaturated Fatty Acids Treatment on Lipid Pattern of HIV Patients: A Meta-Analysis of Randomized …
- In 17 trials with 376 people with familial hypercholesterolemia, adding plant sterols or stanols to a cholesterol-lowering diet reduced total and LDL cholesterol by about 0.45 to 0.6 mmol/L more than diet alone.Diet and Cardiovascular Disease Risk Among Individuals with Familial Hypercholesterolemia: Systematic Review and Meta-An…
- In 11 trials with 331 children and adults with familial high cholesterol, most outcomes showed no significant difference with plant sterols, and no firm conclusions could be drawn due to limited data.Dietary treatment for familial hypercholesterolaemia.
- In people with familial high cholesterol, about 2.3 grams per day of plant sterols or stanols in fat spreads for about 6.5 weeks lowered LDL cholesterol by 10 to 15 percent compared with control.Phytosterols/stanols lower cholesterol concentrations in familial hypercholesterolemic subjects: a systematic review wit…
- Across 124 studies, plant sterols and stanols at about 0.6 to 3.3 grams per day lowered LDL cholesterol by about 6 to 12 percent, with the effect rising up to about 3 grams per day.LDL-cholesterol-lowering effect of plant sterols and stanols across different dose ranges: a meta-analysis of randomised…
- Across 32 trials using at least 1.5 g per day of plant sterols, all carrier fats lowered total and LDL cholesterol, and rapeseed or canola based spreads lowered LDL cholesterol more than soybean or sunflower spreads.Fat type in phytosterol products influence their cholesterol-lowering potential: A systematic review and meta-analysis o…
- Pooled randomized trials in postmenopausal women found plant sterols and stanols lowered total cholesterol by about 17 mg/dl and LDL cholesterol by about 10 mg/dl, with larger drops at 2 grams a day or more, but no change in triglycerides or HDL cholesterol.The effects of phytosterol and phytostanol supplementation on the lipid profile in postmenopausal women: A systematic re…
- In people with high cholesterol, phytosterols lowered total and LDL cholesterol without changing HDL cholesterol or triglycerides, with larger effects at higher doses.Effects of phytosterol supplementation on lipid profiles in patients with hypercholesterolemia: a systematic review and …
- Across 125 studies, foods fortified with plant sterols and stanols lowered LDL cholesterol by an average of 0.55 mmol/L, with larger drops at higher daily doses.Use of phytosterol-fortified foods to improve LDL cholesterol levels: A systematic review and meta-analysis.
- A review pooling 17 meta-analyses found phytosterols lowered LDL cholesterol by about 11 mg/dL, total cholesterol by about 13 mg/dL and triglycerides by about 4 mg/dL, with no change in HDL cholesterol, and larger effects at 2 grams a day or more for over 8 weeks.The effect of phytosterol supplementation on lipid profile: A critical umbrella review of interventional meta-analyses.
- Across 27 controlled diet trials, swapping carbohydrate for polyunsaturated fat lowered LDL cholesterol and triglycerides and raised HDL cholesterol, with the HDL rise getting smaller as fats became more unsaturated.Effect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials.
- In six trials of 527 people taking more than 2 grams per day, both EPA and DHA lowered triglycerides and oxidative stress, while DHA also raised HDL cholesterol and LDL cholesterol; effects on inflammation and blood sugar were inconclusive.The Differential Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Cardiometabolic Risk Factors: A Systematic…
- In children and adolescents with dyslipidemia, phytosterol supplementation lowered LDL cholesterol by about 10 percent after 8 to 12 weeks, with no significant change in HDL cholesterol or triglycerides.Phytosterol supplementation in the treatment of dyslipidemia in children and adolescents: a systematic review.
- A review of systematic reviews and trials graded foods with added plant sterols or stanols as causing at least moderate reductions in LDL cholesterol, with high certainty of evidence.The effects of foods on LDL cholesterol levels: A systematic review of the accumulated evidence from systematic reviews …
- A review of 141 meta-analyses found that phytosterols, in 12 of them, lowered total cholesterol by 16.4 mg/dl, LDL cholesterol by 23.7 mg/dl and triglycerides by 8.85 mg/dl, and raised HDL cholesterol by 10.6 mg/dl.Targeting dyslipidemia by herbal medicines: A systematic review of meta-analyses.
- In children and adolescents with familial high cholesterol, plant sterols at about 1.2 to 2.8 grams per day lowered LDL cholesterol by 10 to 18 percent compared with control groups.Nutrition and dietary interventions for treatment and management of familial hypercholesterolaemia in children and adole…
- A review of nutraceuticals for fatty liver disease concluded that omega-3 fats, among others, may help liver fat and related markers when dosed well and taken for longer periods alongside lifestyle changes.Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence.
- An umbrella review of 48 studies found that canola, virgin olive, and rice bran oils lowered total and LDL cholesterol, while coconut and palm oils raised total and LDL cholesterol, with evidence certainty ranging from moderate to very low.Health Effects of Various Edible Vegetable Oil: An Umbrella Review.
- A narrative review of omega-3 fats found small blood pressure reductions in some trials and suggested lipid profile benefits, but the studies varied too much to set a clear dose.OMEGA-3 POLYUNSATURATED FATTY ACIDS AND HYPERTENSION: A REVIEW OF VASOACTIVE MECHANISMS AND IMPLICATIONS FOR CARDIOVASCU…
- In children followed from ages 9 to 19 in a dietary trial, meeting more dietary targets for fat quality, fiber, and sugar was linked to larger LDL particles and lower lipid levels in several lipoprotein subclasses.Achievement of the Targets of the 20-Year Infancy-Onset Dietary Intervention-Association with Metabolic Profile from Chi…
- In 486 people with metabolic syndrome over 12 weeks of four diets, classifying obesity by body fat percentage rather than BMI identified people at higher cardiometabolic risk, and the study did not test an omega-3 supplement effect on cholesterol.Obesity and body fat classification in the metabolic syndrome: impact on cardiometabolic risk metabotype.
- In 406 heart attack patients, a diet higher in complex carbohydrates, plant and fish protein, and polyunsaturated fats, and lower in calories, salt and cholesterol, lowered total and bad cholesterol and triglycerides over 6 weeks more than the comparison diet did.An Indian experiment with nutritional modulation in acute myocardial infarction.
- In 361 obese adults over 3 months, both a polyunsaturated-fat diet and a monounsaturated-fat diet lowered total and LDL cholesterol, but HDL cholesterol rose only in people without the T allele of rs822393.Dietary intervention with 2 different fat profiles; role of the rs822393 variant in metabolic parameter changes.
- In 309 adults with type 2 diabetes and high triglycerides, 4 g of fish oil daily for 12 weeks lowered triglycerides more than corn oil, with a mean drop of 1.51 mmol/L versus 0.66 mmol/L.Impact of omega-3 fatty acids on hypertriglyceridemia, lipidomics, and gut microbiome in patients with type 2 diabetes.
- In 260 adults with modestly high triglycerides and cholesterol, 4 weeks of a spread providing 2 g per day of plant sterols lowered LDL cholesterol by about 5% and total cholesterol by about 4% compared with placebo.A low-fat spread with added plant sterols and fish omega-3 fatty acids lowers serum triglyceride and LDL-cholesterol con…
- In 259 older adults with memory complaints, a fish oil and cocoa flavanol combination taken for one year lowered triglycerides compared with control, but did not improve cognition.A combined DHA-rich fish oil and cocoa flavanols intervention does not improve cognition or brain structure in older adu…
- Chinese adults who drank low-fat milk with 1.5 grams a day of added phytosterols for 3 weeks had about 9.5 percent lower LDL cholesterol than those who drank conventional low-fat milk.Randomized controlled trial of the effect of phytosterols-enriched low-fat milk on lipid profile in Chinese.
- In 202 people with metabolic syndrome, 6 months of 2 g per day of free plant sterol nanoparticles led to fewer people with high triglycerides and a modest waist reduction compared with placebo, without reported side effects.Effects of Daily Consumption of an Aqueous Dispersion of Free-Phytosterols Nanoparticles on Individuals with Metabolic S…
- In people with impaired glucose regulation, plant sterols alone for 12 weeks lowered triglycerides and high-sensitivity CRP compared with placebo, but did not change total or LDL cholesterol.A combination of omega-3 and plant sterols regulate glucose and lipid metabolism in individuals with impaired glucose re…
- In 200 mildly high-cholesterol Indian adults, 2 g per day of fish oil omega-3 for 4 weeks lowered triglycerides by 15% and raised HDL cholesterol by 5.4% versus placebo, without significantly changing total cholesterol.Independent and interactive effects of plant sterols and fish oil n-3 long-chain polyunsaturated fatty acids on the plas…
- In a 4-week randomized trial of 190 adults at increased heart risk, plant sterol supplements did not lower LDL cholesterol more than placebo, while a low-dose a med lowered it significantly more than placebo.Read the study on PubMed (36351465) →
- In 180 people with type 2 diabetes and dyslipidemia, 3 g per day of different omega-3 sources for 6 months each improved some lipid measures, with fish oil lowering triglycerides and perilla oil lowering LDL cholesterol more than fish oil.[Effects of ω-3 polyunsaturated fatty acids from different sources on glucolipid metabolism in type 2 diabetic patients …
- In 162 dialysis patients, 1.7 grams a day of omega-3 fats for 3 months did not change adiponectin, a blood protein linked to heart health, compared with placebo.n-3 polyunsaturated fatty acids and adiponectin in patients with end-stage renal disease.
- In 156 adults with central obesity, 12 weeks of diets with red palm olein, coconut oil or olive oil had similar effects on inflammation, and olive oil lowered LDL cholesterol more than the other two oils.Diverse impacts of red palm olein, extra virgin coconut oil and extra virgin olive oil on cardiometabolic risk markers i…
- In 153 adults with mild high cholesterol, eating margarine with sitostanol ester (1.8 or 2.6 g sitostanol a day) for one year lowered total cholesterol by about 10 percent and bad cholesterol by about 14 percent, compared with a small rise in the control group.Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population.
- In 150 adults with prediabetes or type 2 diabetes over 12 months, a low-carbohydrate high polyunsaturated fat diet lowered LDL cholesterol compared with usual care, to a similar extent as a healthy Nordic diet.Effects of an anti-lipogenic low-carbohydrate high polyunsaturated fat diet or a healthy Nordic diet versus usual care o…
- In 146 healthy normal weight adults, 2 weeks of a tomato extract rich in lycopene and plant sterols improved the oxidized LDL response to a high-fat meal compared with placebo, while blood sugar, insulin and triglyceride responses did not change significantly.Proprietary tomato extract improves metabolic response to high-fat meal in healthy normal weight subjects.
- In 133 Chinese adults with type 2 diabetes, 1.6 grams daily of blue mussel lipid extract for 60 days lowered triglycerides and inflammatory markers, but total cholesterol also fell in the corn oil group and did not change with fish oil.Lipid extract from blue mussel (Mytilus edulis) improves glycemic traits in Chinese type 2 diabetic mellitus patients: a…
- In 118 adults with high cholesterol, a 12-week nutraceutical combination containing plant sterols, bergamot, olive fruit, and vitamin K2 did not lower total cholesterol, LDL cholesterol, or triglycerides more than placebo.Randomized, Double-Blind, Placebo-Controlled Trial to Test the Effects of a Nutraceutical Combination Monacolin K-Free o…
- In 110 adults with type 2 diabetes, fish oil capsules taken for 3 months lowered total cholesterol, triglycerides and LDL cholesterol more than corn oil capsules.Improvement in Glycolipid Metabolism Parameters After Supplementing Fish Oil-Derived Omega-3 Fatty Acids Is Associated w…
- In a placebo-controlled trial of 100 adults with high cholesterol, using plant sterol-enriched palm oil for cooking in place of regular palm oil significantly lowered total and LDL cholesterol.Plant Sterol-Enriched Palm Oil Intervention to Improve Lipid Profile and Inflammation Status in Hyperlipidemic Individua…
- In 100 adults with type 2 diabetes and abdominal obesity, 4 grams of fish oil daily for 6 months lowered triglycerides and raised HDL cholesterol compared with placebo, while LDL cholesterol did not change significantly.Treatment for 6 months with fish oil-derived n-3 polyunsaturated fatty acids has neutral effects on glycemic control but…
- Overweight adults with high cholesterol who took a combined nutraceutical with bergamot extract and phytosterols for 8 weeks had lower triglycerides and LDL cholesterol than those on placebo, with lower inflammation markers at the high dose.Three-arm, placebo-controlled, randomized clinical trial evaluating the metabolic effect of a combined nutraceutical con…
- In 90 middle-aged and older Chinese women over 3 months, olive and camellia seed oils had no clear weight effect, with olive oil slightly raising HDL and camellia seed oil lowering AST compared with soybean oil.Effects of n-6 PUFA-rich soybean oil, MUFA-rich olive oil and camellia seed oil on weight and cardiometabolic profiles a…
- Moderately high cholesterol adults taking a combined supplement with 800 mg phytosterols and red yeast rice for 8 weeks had LDL cholesterol drop about 20% compared with a small rise on placebo.A Randomized, Double-Blinded, Placebo-Controlled, Clinical Study of the Effects of a Nutraceutical Combination (LEVELIP …
- In 88 adults with type 2 diabetes, 2,700 mg of omega-3 daily for 10 weeks lowered a blood inflammation marker and improved the blood lipid profile compared with placebo.Beneficial Effects of n-3 Fatty Acids on Cardiometabolic and Inflammatory Markers in Type 2 Diabetes Mellitus: A Clinica…
- Adults already on meds or both who added 2 g plant sterols daily for 4 weeks lowered total and LDL cholesterol further, by about 4 to 8 percent.Additive effects of plant sterols supplementation in addition to different lipid-lowering regimens.
- People with low cardiovascular risk who took a daily capsule combining fermented red rice, plant sterol esters and stanols, curcumin and olive polyphenols for 3 months had lower total cholesterol, triglycerides and LDL cholesterol than those taking placebo.Effects on oral fat load of a nutraceutical combination of fermented red rice, sterol esters and stanols, curcumin, and …
- Adults with high cholesterol who ate bread with 2.3 g phytosterols daily for 4 weeks lowered total cholesterol and LDL cholesterol compared with placebo bread, with HDL and triglycerides unchanged.Bread enriched with phytosterols with or without curcumin modulates lipoprotein profiles in hypercholesterolaemic indivi…
- In 75 adults with high blood lipids over 60 days, a blended oil with a moderate omega-6 to omega-3 ratio raised HDL cholesterol and lowered total cholesterol, and a low-ratio oil lowered total cholesterol and triglycerides, with quality of life also improving.Effects of different n-6/n-3 polyunsaturated fatty acids ratios on lipid metabolism in patients with hyperlipidemia: a r…
- Adults with high cholesterol who ate biscuits with 2 grams a day of plant sterols for 6 weeks had lower total and LDL cholesterol than those on placebo biscuits, and adding oat beta-glucan lowered cholesterol further.High molecular weight oat β-glucan enhances lipid-lowering effects of phytosterols. A randomised controlled trial.
- Adults with high cholesterol who took 2 g per day of phytosterols for 4 weeks lowered total and LDL cholesterol compared with placebo, and the combination with curcumin lowered them more.Curcumin potentiates cholesterol-lowering effects of phytosterols in hypercholesterolaemic individuals. A randomised con…
- In 67 adults with high cholesterol over 90 days, a personalized supplement plan that included plant sterols and other supplements lowered bad cholesterol by about 25 percent, compared with about 15 percent with standard physician-guided supplements, though the plant sterols alone cannot be separated out.Efficacy of AI-Guided (GenAISTM) Dietary Supplement Prescriptions versus Traditional Methods for Lowering LDL Cholestero…
- In 64 adults at high risk of type 2 diabetes, 12 weeks of omega-3 capsules alone lowered triglycerides versus placebo but did not significantly improve insulin sensitivity, while curcumin improved insulin sensitivity.Curcumin and/or omega-3 polyunsaturated fatty acids supplementation reduces insulin resistance and blood lipids in indiv…
- In 60 adults with high cholesterol resistant to a Mediterranean diet, a combined supplement with 800 mg of phytosterols, red yeast rice and tyrosol for 8 weeks lowered total cholesterol by 16 percent and bad cholesterol by 23 percent, compared with a placebo group.Short-Term Effects of a Combined Nutraceutical on Lipid Level, Fatty Liver Biomarkers, Hemodynamic Parameters, and Estim…
- In healthy adults given margarine with about 3 grams a day of plant sterols for 6 weeks, blood levels of plant sterol oxidation products rose with dose but stayed below cholesterol oxidation products; cholesterol lowering was not the outcome measured.Serum Concentration of Plant Sterol Oxidation Products (POP) Compared to Cholesterol Oxidation Products (COP) after Inta…
- In a small 3-month trial of postmenopausal women, a herbal supplement containing plant sterols at 1,500 or 3,000 mg per day was associated with lower total and LDL cholesterol than hormone therapy, which had raised them.Short-term effects and safety of a natural oral supplement containing glucosinolates, phytosterols, and citrus flavonoid…
- In 60 hemodialysis patients over 2 months, daily fish oil or corn oil supplements raised good HDL cholesterol and lowered bad LDL cholesterol compared with placebo, and fish oil also lowered triglycerides.Lipid-lowering effect of polyunsaturated fatty acids in hemodialysis patients.
- In 60 adults with metabolic syndrome and fatty liver disease, 3.6 grams of omega-3 daily for 1 year reduced liver fat in those who also lost weight and improved the blood lipid profile compared with placebo.Effect of Omega-3 Polyunsaturated Fatty Acids on Lipid Metabolism in Patients With Metabolic Syndrome and NAFLD.
- In 60 volunteers over 8 weeks, a low-fat high-carbohydrate diet raised total cholesterol and was less favorable for blood lipids than higher-fat diets rich in polyunsaturated fat, which lowered it less or raised the good HDL cholesterol.Effects of amount and type of dietary fat on serum lipids, lipoproteins and apolipoproteins in man. A controlled 8-week …
- In two small feeding trials of 59 adults with high LDL cholesterol, a portfolio diet over 4 weeks changed many blood metabolites, including lower cholesterol esters, compared with a control vegetarian diet; the changes are candidate markers of this eating pattern, not proof of a cholesterol benefit.Metabolomic profiling of a cholesterol lowering plant-based diet from two randomized controlled feeding trials.
- In a 120-day pilot trial of 58 Brazilian adults with familial high cholesterol, 2 g per day of phytosterols added to a cardioprotective diet did not significantly change LDL cholesterol compared with placebo.An Adapted Cardioprotective Diet with or Without Phytosterol and/or Krill Oil Supplementation in Familial Hypercholester…
- In 53 adults with mildly high cholesterol, 3.6 g a day of plant sterol esters in salad dressing for 3 weeks lowered bad cholesterol by a further 9.7 percent beyond the control diet, though it also lowered some blood carotenoid levels.Plant sterol esters lower plasma lipids and most carotenoids in mildly hypercholesterolemic adults.
- In 53 mildly high-triglyceride adults eating yoghurt with 3 g per day of omega-3 fats for 10 weeks, HDL cholesterol rose, triglycerides fell, and inflammatory mediators decreased compared with control yoghurt.Randomized placebo-controlled intervention with n-3 LC-PUFA-supplemented yoghurt: effects on circulating eicosanoids and…
- Adults with high cholesterol taking 2.5 g phytosterols daily for 3 weeks lowered total cholesterol, LDL cholesterol and apolipoprotein B compared with placebo, with larger effects in those following a Mediterranean diet more closely.The Effect of Dietary Supplementation with Plant Sterols on Total and LDL-Cholesterol in Plasma Is Affected by Adherence…
- In 50 overweight adults, 12 weeks of a whole-food phytonutrient product improved gallbladder measures but did not change blood cholesterol, triglycerides or oxidative stress markers compared with placebo.A Whole-Food-Based Health Product (A-F Betafood®) Improves Gallbladder Function in Humans at Risk of Gallbladder Insuffi…
- In 50 adults with biopsy-proven fatty liver disease, 6 months of flaxseed and fish oil omega-3 capsules (about 0.95 g per day) lowered triglycerides at 3 months, but the liver score changes were not clearly better than placebo.Omega-3 polyunsaturated fatty acids in treating non-alcoholic steatohepatitis: A randomized, double-blind, placebo-contr…
- In 46 hyperlipidemic adults over 1 month, a dietary portfolio of plant sterols, soy protein, viscous fiber and almonds lowered LDL cholesterol by about 28.6% and C-reactive protein by about 28.2%, similar to lovastatin 20 mg and better than a low-fat control diet (LDL down 8%).Effects of a dietary portfolio of cholesterol-lowering foods vs lovastatin on serum lipids and C-reactive protein.
- In 46 postmenopausal women with metabolic syndrome, 3 months of selenium and omega-3 enriched dairy lowered very low-density lipoprotein cholesterol compared with conventional dairy.[Effects of the intake of dairy products naturally enriched with selenium and omega-3 polyunsaturated fatty acids in a s…
- In 44 adults with high cholesterol already taking meds, 4 g per day of omega-3 fats for 8 weeks lowered small dense LDL, triglycerides, and total cholesterol more than olive oil placebo.Read the study on PubMed (36050695) →
- In 42 adults with mild high cholesterol, a 4-month combination with 1.8 g of plant sterols plus bergamot, artichoke, and hydroxytyrosol did not lower LDL cholesterol more than placebo, and no other cholesterol or oxidative stress measure differed.The effects of a novel nutraceutical combination on low-density lipoprotein cholesterol and other markers of cardiometab…
- In 42 patients with Chagas heart disease over 8 weeks, daily omega-3 capsules with 1.8 grams EPA and 1.2 grams DHA lowered triglycerides more than corn oil placebo.Omega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical st…
- In 42 men with coronary artery disease, 1,200 mg of omega-3 daily for 8 weeks lowered LDL cholesterol and a blood inflammation marker compared with placebo.Effect of Omega-3 Polyunsaturated Fatty Acids Supplementation on Body Composition and Circulating Levels of Follistatin-…
- In two small trials of people with moderately high cholesterol, yoghurt with 1 to 2 g of plant sterols a day for 4 to 8 weeks lowered cholesterol by about 5 to 6%, but the differences from placebo were not statistically significant.Effects of yoghurt enriched with free plant sterols on the levels of serum lipids and plant sterols in moderately hyperc…
- In 40 overweight adults, 12 weeks of a probiotic containing plant sterols lowered total cholesterol by about 11 mg/dL and LDL cholesterol by about 10 mg/dL more than placebo.Effects of a Probiotic Formulation Based on SF68, Phytosterols, and 6S-5-Methyltetrahydrofolic Acid on Body Composition,…
- In 40 people with heart failure over 12 weeks, omega-3 fish oil at 1 or 4 grams daily impaired the antioxidant function of HDL cholesterol compared with placebo, with a stronger effect at the higher dose.Polyunsaturated fatty acids supplementation impairs anti-oxidant high-density lipoprotein function in heart failure.
- In two feeding studies of 38 people, the ratio of plasma campesterol to 5-alpha-cholestanol was identified as a marker of how much plant sterol people eat; cholesterol lowering was not tested as an outcome.Plasma biomarker of dietary phytosterol intake.
- In 36 healthy young adults, eating omega-3 enriched eggs (777 mg omega-3 daily) for 3 weeks lowered triglycerides, C-reactive protein and blood pressure compared with ordinary eggs.Omega-3 polyunsaturated fatty acids-enriched hen eggs consumption enhances microvascular reactivity in young healthy ind…
- In 34 overweight men on a ketogenic Mediterranean diet for four weeks, total and bad (LDL) cholesterol fell in both groups, but adding omega-3 fatty acids produced larger drops in triglycerides and inflammatory markers without a stated extra cholesterol benefit.Effects of n-3 polyunsaturated fatty acids (ω-3) supplementation on some cardiovascular risk factors with a ketogenic Me…
- In a crossover trial of 34 adults with familial high cholesterol taking meds, 4 grams per day of omega-3 for three months lowered total cholesterol, LDL cholesterol, and triglycerides compared with olive oil capsules.Effect of N-3 Polyunsaturated Fatty Acids on Lipid Composition in Familial Hypercholesterolemia: A Randomized Crossover …
- In 32 overweight healthy adults, 4 weeks of phytosterol-enriched milk did not change lipid-associated plasma proteins, but it lowered inflammatory markers such as serum amyloid P and CCL2.Phytosterols and Omega 3 Supplementation Exert Novel Regulatory Effects on Metabolic and Inflammatory Pathways: A Proteo…
- Healthy adults taking 1.5 g per day of a phytosterol emulsion for one month lowered LDL cholesterol by about 10% compared with placebo.A Randomized, Placebo-Controlled, Double-Blind Crossover Study to Assess a Unique Phytosterol Ester Formulation in Lower…
- In 29 people with diabetic kidney disease followed for one year, 4.6 grams a day of fish oil lowered triglycerides but raised total and bad cholesterol compared with olive oil placebo.Fish oil in diabetic nephropathy.
- In 28 healthy young men eating omega-3 enriched meat and eggs for eight weeks, plasma and blood cholesterol levels did not change compared with a control group eating normal food, although omega-3 levels in red blood cells rose.Effect of Food with Low Enrichment of N-3 Fatty Acids in a Two-Month Diet on the Fatty Acid Content in the Plasma and Er…
- In 26 healthy adults, omega-3 fats taken in a single meal were absorbed about equally whether the meal contained butter or sunflower oil; the study did not measure cholesterol.Kinetics of omega-3 polyunsaturated fatty acids when co-administered with saturated or omega-6 fats.
- In 23 men with high cholesterol, 2.6 g per day of plant sterols for 12 weeks lowered total cholesterol and raised HDL cholesterol compared with baseline, but the added benefit over diet alone was small and limited to one HDL subfraction.Effects of phytosterol supplementation on lipoprotein subfractions and LDL particle quality.
- In an 8-week crossover trial of 23 children with high cholesterol who took at least 70% of doses, a daily plant sterol-enriched olive oil spread lowered total and LDL cholesterol.Chemometrics-guided plasma lipidomics insights underlying the decrease of plasma total cholesterol and LDLc in children …
- In 19 adults, 1.8 g of plant sterols a day in margarine lowered bad cholesterol by about 6 percent compared with control only when split into three doses with meals; a single daily dose at breakfast did not change bad cholesterol significantly.Plant sterol consumption frequency affects plasma lipid levels and cholesterol kinetics in humans.
- In 17 healthy adults, three days of eating polyunsaturated fat instead of saturated fat lowered total cholesterol compared with the saturated fat diet and raised Lachnospiraceae gut bacteria.Replacing saturated fatty acids with polyunsaturated fatty acids increases the abundance of Lachnospiraceae and is assoc…
- In a small crossover pilot of 15 people with familial high cholesterol, omega-3 fatty acid supplements improved blood lipids compared with placebo, although they did not change gut bacteria.Reduced gut microbial diversity in familial hypercholesterolemia with no effect of omega-3 polyunsaturated fatty acids i…
- In 14 adults with high cholesterol, 1.8 g a day of plant sterols or stanols mixed into butter lowered bad cholesterol by about 9 to 14 percent compared with a cornstarch control, but did not change the size of LDL particles.Unesterified plant sterols and stanols do not affect LDL electrophoretic characteristics in hypercholesterolemic subject…
- In 10 healthy adults, a single meal rich in omega-3 fats raised LDL cholesterol after eating more than a fat-free meal, although this was a one-time test and not a supplement study.Fatty acid composition of isoenergetic meals drives distinct postprandial immunometabolic responses in healthy adults: A…
- In a small crossover trial, 2 g per day of plant sterols for 4 weeks lowered triglycerides by about 0.46 mmol/L only in people carrying two copies of the G allele of the CETP rs5882 gene variant, with no effect in A-allele carriers.Cholesterol ester transfer protein polymorphism rs5882 is associated with triglyceride-lowering in response to plant ste…
- In young children aged 12 to 30 months given formula fortified with polyunsaturated fatty acids for four months, blood fat levels improved compared with formula without them.Effect of Milk-Based Infant Formula Fortified with PUFAs on Lipid Profile, Growth and Micronutrient Status of Young Chil…
- In overweight postmenopausal women over 16 weeks, a DHA-rich omega-3 supplement lowered blood triglycerides and diastolic blood pressure compared with an olive oil placebo.Effects of DHA-Rich n-3 Fatty Acid Supplementation and/or Resistance Training on Body Composition and Cardiometabolic Bi…
- In 90 people with chronic pancreatitis and metabolic syndrome, adding omega-3 fatty acids (Omacor, 1680 mg daily) for one month improved blood fat levels and oxidative balance more than standard treatment alone.Optimization of the complex therapy of chronic pancreatitis with metabolic syndrome.
- In 60 people with high triglycerides, 3 g per day of fish oil for six weeks lowered triglycerides by 28 percent, raised HDL cholesterol by 4 percent, lowered small dense LDL cholesterol by 16 percent, and reduced several oxidative stress markers compared with placebo.N-3 polyunsaturated fatty acids in the treatment of atherogenic dyslipidemia.
- In people with higher inflammation markers, a cholesterol-lowering food portfolio including plant sterols for one month reduced C-reactive protein about as much as a starting dose of lovastatin.Read the study on PubMed (15900306) →
- Women with gestational diabetes who ate a phytosterol-enriched spread daily for 16 weeks had lower total and LDL cholesterol and triglycerides and higher HDL cholesterol than baseline, with better blood sugar and insulin resistance measures.A Phytosterol-Enriched Spread Improves Lipid Profile and Insulin Resistance of Women with Gestational Diabetes Mellitus:…
- In postmenopausal women, a plant sterol beverage (2 g a day) for 6 weeks lowered total and bad cholesterol, and adding galactooligosaccharides did not change this effect.Influence of Galactooligosaccharides on the Positive Effect of Plant Sterol-Enriched Beverages on Cardiovascular Risk an…
- In 201 obese, insulin-resistant children given 1.8 g of omega-3 fats daily for 12 weeks, triglycerides fell significantly and insulin and glucose levels also decreased.Omega-3 polyunsaturated fatty acids reduce insulin resistance and triglycerides in obese children and adolescents.
- In 53 people with type 2 diabetes taking meds, 6 weeks of chocolate with 2.2 g per day of plant sterols plus fish oil and green tea lowered LDL cholesterol by about 14% and C-reactive protein by about 36%, though the study was small and uncontrolled.Read the study on PubMed (29503145) →
- In 44 adults with borderline high cholesterol, one tablet daily containing phytosterols and other plant extracts lowered LDL cholesterol by about 7 to 10 mg/dL over 6 months in an uncontrolled study.Effects of Novel Nutraceutical Combination on Lipid Pattern of Subjects with Sub-Optimal Blood Cholesterol Levels.
- In 39 adults with metabolic syndrome, a diet with polyunsaturated fat muffins for 6 months lowered triglycerides more than a monounsaturated fat diet, but total and LDL cholesterol did not change.Poly is more effective than monounsaturated fat for dietary management in the metabolic syndrome: The muffin study.
- In 26 adults with fatty liver, one year of 2 grams daily of dispersed phytosterols reduced liver fat by about 19 percent and improved triglycerides, HDL cholesterol and C-reactive protein in an uncontrolled pilot study.Efficacy of Submicron Dispersible Free Phytosterols on Non-Alcoholic Fatty Liver Disease: A Pilot Study.
- In 14 Japanese adults with type 2 diabetes and high triglycerides, 4 grams a day of omega-3 fats for 12 weeks lowered total cholesterol, bad cholesterol and triglycerides, with no comparison group.N-3 polyunsaturated fatty acids improve lipoprotein particle size and concentration in Japanese patients with type 2 dia…
- In people on haemodialysis, 8 weeks of a fish oil containing 3.6 g of eicosapentaenoic acid lowered triglycerides by 35% and raised good cholesterol (HDL) by 10%, with the HDL2 fraction rising 36%.Fish oil modifies lipids and reduces platelet aggregability in haemodialysis patients.
- In three large US cohorts, higher long-term dietary phytosterol intake was linked to a modest, non-significant reduction in coronary artery disease risk overall, with a significant reduction only for campesterol.Phytosterol intake and risk of coronary artery disease: Results from 3 prospective cohort studies.
- In 3069 French adults, high dietary linoleic acid intake changed how a common gene variant related to HDL cholesterol (lower in high consumers with the variant), while alpha-linolenic acid intake did not.Dietary linoleic acid interacts with FADS1 genetic variability to modulate HDL-cholesterol and obesity-related traits.
- In a population-based older adult study, higher serum phytosterol levels were positively associated with total and LDL cholesterol at normal dietary intakes.Association between Serum Phytosterols and Lipid Levels in a Population-Based Study.
- In a cross-sectional study of 669 parents and children in Mesoamerica, adipose tissue fat levels were linked to metabolic syndrome in mixed directions, with higher EPA linked to more metabolic syndrome and lower ALA and GLA linked to more metabolic syndrome; this does not test supplementation.Adipose tissue polyunsaturated fatty acids and metabolic syndrome among adult parents and their children.
- In 340 overweight or obese adults, dietary fat patterns were linked to blood markers in mixed ways, with higher intake of one pattern linked to lower LDL cholesterol and lower blood pressure, and another linked to higher fasting blood sugar; this is a food-intake study, not a supplement trial.Dietary fatty acid pattern and its association with metabolic profile among overweight and obese adults.
- In 335 adults with cardiovascular risk factors, higher red blood cell omega-3 levels were linked to larger LDL particles and less small dense LDL cholesterol.Red Blood Cells' Omega-6 and Omega-3 Polyunsaturated Fatty Acids Have a Distinct Influence on LDL Particle Size and its …
- In 185 children with a kidney condition, lower omega-3 DHA and higher omega-6 arachidonic acid levels were linked to higher triglycerides and metabolic syndrome.Read the study on PubMed (40140875) →
- In 54 children with high cholesterol, most had low omega-3 levels in red blood cells, and fatty acid patterns were linked to some lipid measures.Serum lipid profile and fatty acid composition of erythrocyte phospholipids in children and adolescents with primary hyp…
- In 20 overweight adults, 4 weeks of milk with 1.6 g of phytosterols a day changed the HDL good-cholesterol lipid profile less than milk with omega-3 fats did, and the study did not show a clear cholesterol-lowering benefit.Dietary ω3 Fatty Acids and Phytosterols in the Modulation of the HDL Lipidome: A Longitudinal Crossover Clinical Study.
Review Totals and Summary
Members Only23 reviews · 100% positive
23 reviews · QFC 6 · King Soopers 6 · Google 6 · Walmart 5
100% positive0% neutral0% negative
Across the three stores there are 17 ratings in total (5 at Walmart, 6 at QFC and 6 at King Soopers), and the themes below come from the few written reviews that could be read on their pages. Only a handful of written comments were readable, and the same review from M Feradov appears to be repeated on all three pages, so it should not be counted as three separate opinions. The wording here covers the tablets only, and the summaries did not mention any other forms of the product. What buyers praise: Every written comment is positive. M Feradov calls it a really good natural supplement and says a difference was noticeable after only a few days of use. Gerald, whose Walmart review is marked as a verified purchase and an incentivized review, calls it a great supplement and says it gave lots of energy, helped healing and supported muscle growth. A third Walmart reviewer, tra, calls it a great product with great gains. The recurring themes are effects noticed within days, energy, support for recovery and healing, and muscle gains. Who it seems to suit: The feedback is framed around training. M Feradov recommends it to anyone who is training, and the other comments describe gains, muscle growth and healing, so it appears to appeal to people who exercise and want help with recovery and strength. Complaints: None of the readable written reviews contain a complaint. Nobody reports side effects, taste problems, size problems, or concerns about price, packaging or the tablets themselves. This reflects the absence of negative text, not a verified lack of problems. Taste, form, value and use: The reviews say nothing about taste, tablet size, ingredients, how the product was taken, dosing, value for money, or results over a longer period, so none of those can be judged from this feedback. Star ratings: The ratings are consistently favorable. At Walmart, 80% of ratings are five stars and 20% are four stars, with no lower scores. At QFC the ratings are two five-star and four four-star, averaging 4.33. At King Soopers the distribution is entirely four and five stars. Across all pages, no three-, two- or one-star ratings appear. Other notes: Several entries on the QFC and King Soopers pages, including one by mark34664 and an anonymous one, show only a rating and a note that the review was originally posted on pipingrock.com, with no written text. One Walmart review is likewise shown alongside a review from pipingrock.com. A few written reviews were readable in total, so the themes are narrow: quick noticeable results, energy, recovery and muscle gains, with consistently high star ratings but little detail beyond that.
Biohacker Summary
Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it
Our biohacker panel has not discussed this product’s ingredients yet.
RAL Summary
Members OnlyTier 4 for Cholesterol
Plant sterols have strong human evidence for lowering cholesterol [1], but the sterol amount is hidden inside a blend and there are only 23 reviews, too few to rank higher than emerging.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 24 of the 131 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Cardiovascular system, Musculoskeletal system
Combine with: For cholesterol support, phytosterols work well with soluble fiber such as psyllium or beta-glucan, which further reduce cholesterol absorption. Omega-3 fish oil helps lower triglycerides and supports overall heart health. Bergamot extract or red yeast rice (under medical guidance) can add LDL-lowering effects, and CoQ10 is useful if a med is used. Take phytosterols with meals, since they work in the gut alongside dietary fat. For the original anti-aging goal, choose products with NMN or NR, resveratrol, quercetin, PQQ, and alpha-lipoic acid. Consult a healthcare provider, especially if taking meds.
Possible side effects: No major side effects reported.
Supplement Facts
Sterol Complex 2000 mg · Mass and Density Blend 2500 mg · Opti-Phytonutrient Complex 2000 mg
Supplement Facts
Serving Size 3-6 Tablet(s)
Servings Per Container 30
Amount Per Serving% Daily Value
| Sterol Complex | 2,000 mg | † |
| Mass and Density Blend | 2,500 mg | † |
| Opti-Phytonutrient Complex | 2,000 mg | † |
| EFA Complex & Support Blend | 500 mg | † |
| Muscle Cell Protection Blend | 500 mg | † |
† Daily Value not established.
Other ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Silicon Dioxide, Stearic Acid, Magnesium Stearate, Pharmaceutical Glaze.
Directions: Dosage: Take 3 to 6 tablets with any meal or half an hour before training with plenty of water.
Barcode (UPC) 039442043924 · Label source: NIH label database · Report a label change
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More cholesterol products
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Our articles on this subject
- Best Diet for High Cholesterol: What to Eat, What to Cut, and What the Trials ShowArticle · Sep 13, 2026
- How to Lower LDL Cholesterol: A Practical Plan Based on Your Blood WorkArticle · Oct 27, 2026
Graded November 7, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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