Wholesome Story Myo-Inositol & D-Chiro Inositol Supplement for Women | Fertility Supplements for Hormonal Balance & Ovarian Health Support | Myoinositol | Ideal 40:1 Ratio | 30 Servings Review
Myo-Inositol & D-Chiro Inositol is a supplement blend of 2,000 mg of Myo-Inositol and 50 mg of D-Chiro Inositol per serving, in a 40:1 ratio. The product is positioned to support hormones, a healthy cycle, and ovarian and reproductive health. The page states that myo-inositol is found naturally in plant foods such as grains, corn and legumes. The listed benefits are daily hormone support, support for a healthy cycle, ovarian and reproductive health support, and support for healthy metabolic function. Each serving is 4 capsules, and the container holds 30 servings. The page explains that inositol is a sugar-like molecule found in every cell of the body, and that myo-inositol is the most common form of inositol. It describes myo-inositol as a building block for molecules that relay messages inside cells, and it says D-chiro-inositol is made by the body from myo-inositol. The product is sourced from corn, according to the page, and it is described as containing no animal products, gluten, soy or nuts. The page says the product is made in a facility that also processes common food allergens. Third-party testing and certifications are listed, including the Clean Label Project Purity Award, Clean Label Project Certified, NSF Contents Certified and NSF Certified Gluten-Free. The page recommends taking 1 serving up to twice a day or as directed by a physician, and it suggests 3 to 6 months of consistent daily use. It advises consulting a healthcare provider before use if pregnant, nursing, contemplating pregnancy, or taking medications, especially those that lower blood sugar. The page also warns that the product may cause hypoglycemia in some individuals and lists symptoms. The page states that its supplement statements have not been evaluated by the Food and Drug Administration and that the product is not intended to diagnose, treat, cure, or prevent any disease.
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Study, Trial or Testing Result Summary
Members Only7 human studies · 3 improved
This product gives a full daily amount of myo-inositol, but the human evidence for women's hormone goals is mixed and leans toward no clear effect. A 2026 pooled analysis of 16 trials in women with polycystic ovary syndrome found no treatment significantly changed insulin resistance, and the largest weight losses came from a newer class of meds, not inositol [1]. A 2014 pooled analysis of 11 placebo-controlled trials found no significant symptom improvement, only a trend toward less depression in severe premenstrual mood disorder [2]. A small trial of 11 women with that disorder found no benefit over placebo [3]. On the positive side, a 2011 controlled trial found myo-inositol improved premenstrual symptom and depression scores compared with placebo [4], and a six-month trial in 40 women going through menopause found it lowered insulin [5]. The D-chiro-inositol here is only a trace amount, far below the dose used in the one small human study. That uncontrolled pilot found a thinner womb lining and less heavy bleeding in women with a non-cancerous thickening of the lining [6]. A mouse study of endometriosis showed smaller lesions, but animal results may not apply to women [7]. Animal and cell studies are never counted.
See all 7 studies →Hide the studies
- Pooling 11 placebo-controlled trials (312 people with depression or anxiety, including two trials in premenstrual dysphoric disorder), inositol did not significantly improve symptoms, though there was a trend toward benefit for depression in premenstrual dysphoric disorder.A meta-analysis of inositol for depression and anxiety disorders.
- In a pooled analysis of 16 trials in women with polycystic ovary syndrome, none of the treatments significantly changed insulin resistance, and the largest weight and body mass index reductions came from meds, not inositol.Read the study on PubMed (42490840) →
- In 40 women going through menopause, 4 grams a day of myo-inositol alone or with melatonin for 6 months lowered insulin in both groups, and thyroid-stimulating hormone fell only in the myo-inositol-alone group.Myo-inositol and melatonin in the menopausal transition.
- In a small crossover trial of 11 women with premenstrual dysphoric disorder, 12 g of myo-inositol daily during the luteal phase gave no benefit over placebo glucose across six menstrual cycles.Myo-inositol has no beneficial effect on premenstrual dysphoric disorder.
- In women with premenstrual dysphoric disorder, myo-inositol as powder or soft gel capsules improved daily symptom, depression and overall severity scores compared with placebo, with similar results for both forms.Myo-inositol in the treatment of premenstrual dysphoric disorder.
- In a small uncontrolled pilot, women with simple endometrial hyperplasia without atypia who took 600 mg of D-chiro-inositol daily for six months had thinner uterine lining, falling from 10.82 mm to 6.9 mm, and improved heavy menstrual bleeding.D-Chiro-Inositol in Endometrial Hyperplasia: A Pilot Study.
- In a mouse model of endometriosis, D-chiro-inositol given at 0.4 mg daily for 28 days reduced the number, size and blood vessel growth of endometriotic lesions compared with untreated mice; this was an animal study, not a human trial.D-chiro-inositol effectively counteracts endometriosis in a mouse model.
Review Totals and Summary
Members Only73,102 reviews · 86% positive
This supplement has garnered significant attention, with approximately 73,102 ratings across various stores. The vast majority of feedback is positive, with 80% of star ratings being 4 or 5 stars. **What it did for them** Many users report positive changes, particularly concerning hormonal balance. Some experienced a "huge difference in my hormones" within about a month. The supplement has also been "very helpful with my insulin resistance" for some individuals. Reviewers frequently mention improved appetite control, noting a reduction in cravings for sugary and fatty foods, and a decreased urge to binge on sweets. Better overall mood and a more feminine, softer manner are also reported. A few users experienced lighter menstrual pain. While some link the product to weight loss, they often acknowledge that other lifestyle changes, such as diet and exercise, were also contributing factors. Importantly, some users noted "no negative side effects" even in early use. **Complaints** Not all users experienced significant benefits. Some reviewers were "Not sure if I noticed much of a difference," or felt that "If there was, it wasn't significant." A small number of users found the product "not effective at all." It's worth noting that some feedback suggests effects can take one to three months to become noticeable, implying that consistency is key. **Form and Ease of Use** The capsules are generally well-received for their form. Reviewers note that the capsules are easy to swallow and have no gross taste or after-burps. The absence of taste, smell, or issues with pill size is a consistent theme, fitting the capsule format of the product. **Value for Money** For many, this supplement offers good value. One reviewer specifically mentioned it was "More affordable than the other product I was purchasing," suggesting it's a cost-effective option compared to alternatives. **Who it suits** This supplement appears to suit women seeking support for hormonal balance, insulin resistance, appetite control, and mood improvement. Those who have experienced benefits often report them after consistent use, sometimes taking one to three months to see results. However, it may not be suitable for everyone, as some users did not experience a noticeable difference. The feedback highlights that individual results can vary.
Biohacker Summary
Members Only4 of 10 recommend it
Inositol is the main ingredient, and nine of the ten panelists spoke about it, with most of them recommending it or taking it themselves. The most common reason is sleep: six of them take about 900 mg before bed, one takes a scoop of myo-inositol in the evening, and another takes about 5 grams in water at night. Others point to blood sugar and insulin sensitivity, mood and anxiety, and female fertility and egg quality, where one panelist gives a range of 1 to 5 grams per day for women. Myo-inositol is the form named most often, with one mention of D-chiro inositol for insulin sensitivity, and one panelist notes that its sleep evidence is not strong. No one reported stopping it or any side effects, and the only pairing mentioned was taking it with other steps for Hashimoto's.
See all 9 biohackers →Hide the biohackers
Dr. Mark Hyman · Inositol · recommends
- Lists inositol as a supplement that helps balance neurotransmitters and can help lower anxiety or depression symptoms.
- Takes 900 mg of Inositol before bed for sleep.
- Takes 900 mg of Inositol before bed for sleep.
- Takes 900 mg of inositol before bed for sleep.
- Takes 900 mg of inositol before bed for sleep.
- Takes 900 mg of inositol before bed for sleep.
- Recommends inositol for fertility.
- Recommends inositol, considered a B vitamin, for brain and mood function and anxiety, found in oranges, grapefruit, chickpeas, lentils, almonds, peanuts, and leafy greens.
- Added a combination product with myo-inositol and D-chiro-inositol to a young woman's regimen, which helps improve insulin sensitivity and cell signaling.
- Personally started taking myoinositol over a year ago and finds it very helpful for sleep architecture, inducing and maintaining sleep, and quieting the autonomic nervous system. She recommends starting with 1 gram a day and titrating based on symptoms.
Andrew Huberman · Inositol · neutral
- Discusses Myo-Inositol as a tool for middle-of-the-night waking.
- Discusses Myo-inositol as a supplement that can impact serotonin.
- Has been taking 900 mg of myo-inositol every third night or so to test its ability to improve sleep, finding the depth and quality of sleep to be remarkable.
- Takes 900 mg of Inositol before bed for sleep.
- Mentions inositol as a nutraceutical that can be used for bipolar disorder.
- Personally takes 900 mg of myo-inositol every third night or so to improve sleep and for its anti-anxiety effect during the day, but not for bipolar disorder.
- Mentions Inositol as a nutraceutical for OCD.
- Highlights myoinositol, stating that 900 milligrams or higher dosages can improve sleep and reduce anxiety, and suggests more systematic exploration of nutraceuticals like inositol for OCD treatment, especially in combination with behavioral therapies.
- Takes 900 mg of Inositol before bed for sleep.
- Mentions inositol for PCOS, stating it decreases insulin resistance and offers a huge benefit.
Ben Greenfield · Inositol · neutral
- Notes that inositol has solid research behind it for fertility.
- Recommends Inositol at 1 to 5 grams per day for women, noting its involvement in FSH signaling and citing trials showing fewer immature oocytes and more high-quality embryos in women undergoing IVF.
- He discusses inositol for female fertility.
- Myo-inositol has the same insulin-sensitivity mechanism as in men and is tied to egg quality.
- Mentions Inositol with a dose of 1-5 grams/day.
- Takes 900 mg of Inositol before bed for sleep.
- Now uses myo-inositol as a natural strategy instead of a med and as a natural insulin-sensitizer.
- Recommends Myo-inositol as a strong evidence-backed supplement for insulin resistance and PCOS, suggesting a dose of around 2g a couple of times a day.
- He takes 900 mg of Inositol before bed for sleep.
- Takes 900 mg of Inositol before bed for sleep.
Siim Land · Inositol · neutral
- States that Inositol has been shown to improve blood sugar and insulin sensitivity.
- States that Inositol has a key role in glucose metabolism and that grapefruit is one of the richest sources of it.
- He takes 900 mg of Inositol before bed for sleep.
- He takes 900 mg of inositol before bed for sleep.
- Describes Inositol as interesting, noting it is sweet-tasting like glycine and found in grapefruit, and that it lowers blood sugar and cholesterol, though the effects are not massive.
- Likes inositol, stating it helps with neurotransmitters, mood, and blood sugar regulation, placing it in the 'good tier'.
- Used to take inositol in the past but no longer does, as he has already tested most supplements.
- Recommends Inositol, stating that it helps with neurotransmitters, mood, and blood sugar regulation.
- Discusses Inositol as a supplement.
- Lists inositol as one of the three healthiest sweeteners that have no sugar.
Dave Asprey · Inositol · uses
- He takes 900 mg of Inositol before bed for sleep.
- Dave and Lucas break down compounds and systems discussed in the episode including solbutiamine, lithium orotate, sarcosine, inositol, uridine, testosterone, growth hormone, ketamine pathways, thyroid optimization, liver health, sleep quality, and desire regulation.
- Takes about 5 grams of inositol in water at night, noting its amazing and broad-spectrum benefits, especially for mental health.
- Uses Inositol Tris Pyrophosphate (ITPP) sublingually three times a week, taking 250 milligrams, and describes it as feeling like EPO in a capsule, massively improving endurance and mental clarity.
- Recommends utilizing myoinositol to help with sleep by balancing blood sugar.
- Began seeing that people had to have foods high in inositol because it was a nutrient important for the liver to burn fats.
Bryan Johnson · Inositol · uses
- Takes 900 mg of Inositol before bed for sleep.
- Takes 900 mg of Inositol before bed for sleep.
- Takes 900 mg of inositol before bed for sleep.
- Takes 900 mg of Inositol before bed for sleep.
- Takes 900 mg of Inositol before bed for sleep.
- Takes 900 mg of Inositol before bed for sleep.
- Takes 900 mg of Inositol before bed for sleep.
Dr. Rhonda Patrick · Inositol · uses
- Has found myo-inositol helps calm "mental chatter" before bed, although it is not strongly evidenced as a sleep aid.
- Discusses why and how much myo-inositol they took.
- Rhonda's current supplement routine includes Myo-inositol.
- Oh, I also forgot to mention that I take myo-inositol in the evening as well, a scoop of it, and that's Pure Encapsulations.
- Dr. Rhonda Patrick explores if inositol can improve sleep.
- She has been taking one scoop of myo-inositol mixed with water at night, noting a potential benefit to her sleep and its importance for reproductive health.
- She mentions myo-inositol as part of a sleep stack but has not looked into its effects for sleep in depth.
Dr. Eric Berg · Inositol · recommends
- Recommends taking inositol as part of a natural remedy for eye floaters, citing older versions of the PDR.
- Lists Myo-inositol as one of the best natural remedies for OCD.
- Suggests that myo-inositol may also be needed if one has Hashimoto's.
- Recommends myoinositol, part of the B complex, as a natural remedy for OCD, citing good randomized double-blinded control studies.
- Recommends taking myo inositol in addition to other recommendations for Hashimoto's.
- Recommends inositol hexaphosphate (IP6) as a beneficial form of phytic acid for reducing iron.
- Mentions Inositol as another good thing to take for PCOS.
- Recommends taking inositol to help with PCOS and to reset the flow of hormones after an estrogen crash from stopping birth control pills.
- Dr. Berg recommends using inositol for PCOS.
- Recommends D-chiro-inositol, a form of inositol, as it is essential for the hypothalamus-pituitary-gonad axis, helps with many female problems, and makes insulin more sensitive, which is beneficial for PCOS and infertility.
Thomas DeLauer · Inositol · neutral
- Mentions D-chiro inositol as a compound found in buckwheat that has been demonstrated to be very powerful at improving insulin sensitivity.
RAL Summary
Members OnlyTier 3 for Hormone Balance for Women
Tier 3 rests on a very large number of mostly positive reviews (86% of over 73,000). The study support is thin and mixed: a few trials show benefit, while pooled analyses show no clear effect.
- D-Chiro Inositol: trace amount
Where the evidence disagrees: 3 of the 7 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Endocrine system, Reproductive system, Metabolic system, Nervous system
Combine with: To further support hormonal balance and reproductive health, consider combining Myo-Inositol and D-Chiro Inositol with a high-quality folate supplement, such as methylfolate, which is crucial for cellular function and often recommended for women of childbearing age. Omega-3 fatty acids can help reduce inflammation and support overall hormonal health. Vitamin D is also vital for hormone regulation and reproductive function. Additionally, magnesium can aid in stress reduction and various enzymatic processes involved in hormonal balance, while N-Acetyl Cysteine (NAC) may further enhance insulin sensitivity and ovarian function. CoQ10 can also be beneficial for supporting egg quality and mitochondrial health.
Possible side effects: No major side effects reported.
Supplement Facts
Myo-Inositol 2000 mg · D-Chiro Inositol 50 mg
| Myo-Inositol | 2,000 mg | † |
| D-Chiro Inositol | 50 mg | † |
Other ingredients: Methylcellulose (Capsule), Rice Flour.
Directions: Suggested Use: Use 1-2 servings (4-8 capsules) as needed or as directed by your health care professional. Enjoy!
Barcode (UPC) 860003257845 · Label source: Wholesomestory · Report a label change
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Graded October 28, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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