Alani Nu Pre-Workout Blue Slush Review

Looking for a bolder boost? This Pre-Workout+ in the blue slush flavor is described by the brand as a fitness supplement that is refreshingly fierce. The product is marketed to support better pump, added hydration and added focus. Each scoop provides 300mg of caffeine and 200mg of L-theanine per serving. The page describes the flavor as tasting like a retro slushie with sweet, icy swirls of blue raspberry flavor. The product is listed as vegan, with 0g sugar and 300mg of caffeine per scoop. The Nutrition Facts panel lists one scoop (13 g) per serving, with about 30 servings per container, 40 calories, under 1g of carbohydrate, 200mg choline, 40mg calcium, 45mg sodium, 8g L-citrulline malate 2:1, 2g beta-alanine, 300mg caffeine from coffee arabica bean extract and dicaffeine malate, 200mg L-theanine, 100mg theobromine, 100mg pink Himalayan salt and 100mcg huperzine-A. The label states the product contains 300mg of caffeine per serving and is not recommended for children, people sensitive to caffeine, or women who are nursing. It advises that daily caffeine from all sources should be limited to about 400mg per day. The page notes that the statements have not been evaluated by the Food and Drug Administration and that the product is not intended to diagnose, treat, cure or prevent any disease. The page also offers a choice of other pre-workout+ flavors, including frozen lemonade, paradise swirl, kiwiberry, cherry slush and rocket pop, and a bundle with an energy drink.

Product Focus: EnergyAlso covers:BrainMusclesHeartRanked among:Nitric oxide supplements
Tier ⓘ
Tier 2
Tier 2 · Researched. Human studies show improvement in an aging-related function or a specific goal, and the reviews agree. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
85 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
87% of 795
Biohacker Mentions
10 of 10
Cost per month
$45

Study, Trial or Testing Result Summary

Members Only154 human studies · 77 improved

1 of these 154 human studies gave the ingredient by drip, not by mouth.

154 human studies77 improved45 no effect7,009 people studied

Caffeine, at 200 milligrams per serving, has the strongest support for energy. Reviews of many trials found that caffeine before exercise improved self-reported energy, mood and attention [1] and lengthened running time to exhaustion [2]. Single doses of 200 to 400 milligrams reduced boredom and fatigue during repetitive tasks [3]. However, taking it daily for six weeks did not reduce fatigue. Beta-alanine, at 1.6 grams, improved hard exercise lasting half a minute to 10 minutes [4]. At this same daily amount for four weeks, it delayed muscle fatigue in untrained men [5], though the clearest effects came at higher doses of 5.6 to 6.4 grams [4]. Citrulline malate, at 6 grams, gave about 6 percent more repetitions in strength training [6] but did not improve endurance [7]. L-theanine alone at 200 milligrams sharpened attention but did not reduce fatigue [8]. Combined with caffeine, it lowered tiredness and raised alertness [9]. The only trial of L-tyrosine found no effect on fatigue or alertness [10], and the dose that study used is unknown. Animal and cell studies are never counted.

See all 154 studies →Hide the studies

Review Totals and Summary

Members Only795 reviews · 87% positive
795 reviews · Walmart 758 · Alani Nu website 37
87% positive3% neutral10% negative

Alani Nu Pre-Workout Blue Slush gets mostly warm feedback, with buyers praising its taste and its smooth energy. It carries about 795 ratings across the stores, and a small number of buyers had serious problems. This summary covers the powder only; reviews of other forms of the product were left out. **What buyers say it did for them:** Most describe a clear boost for training, with focus and motivation. One says it is "a boost of 'one more rep'," and another feels able to "focus & lift heavy." Store summaries add that the energy is steady and that there is no hard crash. One caregiver who doesn't exercise says it lifted her daily energy, though she takes it in the morning because later doses keep her awake. **What they complain about:** Complaints are few but some are serious. One buyer got sick: "made me sick 30 min after drinking," with vomiting and a hot flash. Others report shipping or condition problems: "item was open and damaged," and powder that arrived "so hard" it couldn't be scooped. One reviewer said it "doesn't really taste like an Alani." A store page notes that opinions on aftertaste vary, though no written review there complains about it directly. Several mention tingling, which one says "passes once you get moving," while another likes that it lacks "that weird itchy feeling." **Taste, smell and form:** Flavor is the most repeated praise. One reviewer says it "tastes just like a slushie," and another calls it "one of the top flavors." A Walmart summary describes a sweet, fruity taste that mixes quickly. One buyer in Canada says they have yet to find the flavor there. **Value for money:** Price comes up mostly as a plus. One buyer needed a cheaper option and calls it "great product for the price," and a store summary also points to an affordable price. **Who it suits and who it did not:** It seems to suit people who want a moderate, focused boost without jitters, including some who rotate between pre-workouts. Caffeine strength is the main caution for newcomers. One reviewer says "its a lot of caffeine in one scoop, so id go half to start!" Another began with half a scoop and is working up to a full one, and a very small buyer (5'4", 86 lbs) takes a little under half. It did not suit the buyer who became ill, and the reports of damaged or hardened product show that condition on arrival can vary, especially with separate shipments.

Biohacker Summary

Members Only10 of 10 recommend it
10 of 10 biohackers on our panel recommend it

On caffeine, the main ingredient, the panel is split, with four of ten using it or recommending it, three warning against it, two neutral, and one who stopped. Those in favor take it for focus, mood, training and fat burning, often before fasted workouts, and two of them suggest 100 to 150 mg paired with L-theanine to smooth out jitters, while others use 300 to 400 mg or add it to coffee with Alpha GPC. Cautions are common: several say to stop caffeine by noon or early afternoon to protect sleep, others link too much to stress, restlessness, anxiety and a faster heart rate, one advises cutting it out for three months before conception, and one came off it for a year. Tyrosine is a smaller ingredient in this product, and two panelists mentioned it as a building block for focus and dopamine chemicals.

See all 10 biohackers →Hide the biohackers
  • Dave Asprey · Caffeine · uses
    • 31 Oct 2026 · uses · YouTube ↗
      Loves coffee, has the caffeine molecule tattooed on his arm, drinks it every morning, and says it does amazing things for your brain and for how long you can live, but it can't clear most brain fog on its own.
    • 23 Oct 2026 · recommends · Instagram ↗
      Created Danger Coffee, a mineral-enriched, lab-tested, mold-free coffee that delivers rich flavor and clean caffeine without all the junk, and recommends it to others.
    • 22 Oct 2026 · recommends · YouTube ↗
      Dave Asprey's lab proved that caffeine is a flow hack and the only known substance to actually make you flow prone. Coffee will make you more flow prone.
    • 11 Oct 2026 · recommends · Podcast ↗
      Dave explains why the 1:2 ratio of caffeine to L-theanine beats coffee alone for working memory, accuracy, and calm, sustained concentration.
    • 11 Oct 2026 · Tyrosine · recommends · Podcast ↗
      Dave explains how L-tyrosine gives your brain the raw materials to make focus chemicals, and mentions the dose and timing that work.
    • 3 Oct 2026 · uses · YouTube ↗
      States that his entire career started on caffeine and he uses it every morning, but notes it's like a loan from your future self, leading to an afternoon crash.
    • 1 Oct 2026 · stopped · YouTube ↗
      Dave Asprey's company used caffeine, which is a safe ingredient, but they stopped using it because it doesn't provide the type of results and change in the skin that newer ingredients do.
    • 25 Sep 2026 · Citrulline · recommends · Facebook ↗
      Notes that a 2011 trial found 1.5 g of L-citrulline daily restored normal erectile function in 50% of men with mild ED, and states that it's worth knowing about for mild ED.
    • 3 Sep 2026 · uses · YouTube ↗
      States that caffeine is one of his superpowers and increases the rate of ketone formation, which fuels neurons.
    • 31 Aug 2026 · uses · Instagram ↗
      Once I’ve hydrated and taken my creatine, I reach for Danger Coffee for caffeine and essential minerals in one cup.
    • 22 Aug 2026 · uses · YouTube ↗
      Uses caffeine, noting it blocks adenosine to increase norepinephrine and dopamine signaling, fueling the prefrontal cortex for focus. He mentions it got him through business school and is part of his longevity journey.
    • 22 Aug 2026 · Tyrosine · uses · YouTube ↗
      Uses L-Tyrosine, an amino acid, to provide the brain with raw ingredients to make dopamine and norepinephrine, which activate the focus switch. He takes 500 mg every morning and advises starting with that dose and working up if needed, ideally on an empty stomach.
    • 13 Aug 2026 · warns · YouTube ↗
      Does not believe caffeine is a nootropic, considering it just a stimulant.
    • 23 Apr 2026 · Tyrosine · neutral · YouTube ↗
      Mentions that some drivers might use tyrosine to balance some of the caffeine.
  • Thomas DeLauer · Caffeine · neutral
    • 29 Oct 2026 · neutral · YouTube ↗
      Explains that caffeine from green tea mobilizes fatty acids, which can be converted into ketones, providing a ketone boost, especially in a fasted or low-carb state.
    • 27 Oct 2026 · warns · YouTube ↗
      Warns that treating brain fog with caffeine without addressing underlying inflammation is ineffective and likely to make the situation worse.
    • 21 Oct 2026 · uses · Facebook ↗
      Notes that caffeine significantly increased fat metabolism and fat oxidation during exercise, especially at lower intensities, and that adding coffee around an exercise bout led to more calories and fat burned.
    • 21 Oct 2026 · uses · Instagram ↗
      Says that caffeine significantly increased fat metabolism and that at low intensity cardio or exercise caffeine works better at mobilizing and utilizing fat.
    • 14 Oct 2026 · uses · YouTube ↗
      Might have some caffeine before fasted training.
    • 26 Sep 2026 · recommends · YouTube ↗
      Recommends caffeine as a must on the fasting day to create a low-grade energy demand that forces the body to favor lipolysis.
    • 2 Sep 2026 · recommends · YouTube ↗
      Recommends drinking 150 to 200 mg of caffeine immediately before a 20-minute nap to enhance alertness and performance, as the caffeine peaks when the nap has cleared adenosine.
    • 1 Sep 2026 · recommends · Instagram ↗
      States that caffeine is probably the most studied ergogenic aid with a profound effect on fat mobilization, suggesting that simple is better.
    • 25 Aug 2026 · neutral · YouTube ↗
      Mentions that people try cutting out caffeine when dealing with sleep issues, but it's not always the root cause.
    • 24 Aug 2026 · Citrulline · recommends · YouTube ↗
      Explains that citrulline, found in watermelon, is converted to arginine, which feeds nitric oxide synthase, amplifying one of the contraction signals that drives glucose into muscle cells, and also helps clear ammonia during exercise, preserving muscle function and accelerating recovery.
    • 15 Aug 2026 · warns · YouTube ↗
      Warns that consuming more than 50-60 mg of caffeine in the first hour after waking stacks a stimulant on top of the body's natural cortisol-driven alertness, leading to a sharp spike and mid-morning crash, and building tolerance faster.
    • 4 Jul 2026 · Citrulline · recommends · YouTube ↗
      Highlights L-citrulline, found richly in watermelon, as an amino acid that feeds into nitric oxide, improving performance, recovery, and reducing muscle soreness by clearing metabolic waste and supporting the urea cycle.
    • 3 Jul 2026 · Beta-alanine · recommends · YouTube ↗
      Recommends beta-alanine, stating it is a rate-limiting precursor to carnosine, which acts as an intracellular pH buffer and improves performance in efforts lasting 1 to 4 minutes.
    • 19 Jun 2026 · Citrulline · recommends · YouTube ↗
      Recommends L-citrulline as it converts to arginine, a precursor to nitric oxide, is calorie-free, doesn't break a fast, and increases plasma nitrite levels.
  • Andrew Huberman · Caffeine · uses
    • 26 Oct 2026 · uses · YouTube ↗
      Used caffeine, taking 400 milligrams, to improve his mood and physical vigor during mundane tasks like swimming, noting that it made life not so bad and allowed him to rip through the water.
    • 26 Oct 2026 · neutral · Podcast ↗
      Mentions caffeine in a discussion about supplement use.
    • 26 Oct 2026 · Tyrosine · neutral · YouTube ↗
      Mentions Tyrosine as a precursor to dopamine.
    • 22 Oct 2026 · neutral · Podcast ↗
      Discusses caffeine timing as a tool related to sleep.
    • 22 Oct 2026 · warns · YouTube ↗
      He recommends caffeine, in coffee or tea form, or in tablet or capsule form at lower dosages than found in coffee and tea, as a reasonable way to explore stimulant-based approaches for enhancing cognitive function and focus.
    • 22 Oct 2026 · Tyrosine · neutral · Podcast ↗
      Discusses L-Tyrosine as a neuromodulator for cognitive enhancement and focus.
    • 22 Oct 2026 · Tyrosine · stopped · YouTube ↗
      He recommends 500 mg to 1,000 mg of L-tyrosine, an amino acid precursor to dopamine, taken alone or in conjunction with alpha GPC, to increase focus without stimulant-based alertness.
    • 1 Oct 2026 · recommends · YouTube ↗
      Huberman states that caffeine can improve focus and concentration, with a general useful range of 100 to 400 milligrams, and most people do well with 100 to 200 milligrams prior to focused work.
    • 1 Oct 2026 · neutral · Podcast ↗
      Discusses caffeine as a tool for improving attention, noting its impact on focus and sleep.
    • 1 Oct 2026 · Tyrosine · uses · YouTube ↗
      Uses 500 milligrams of L-Tyrosine in capsule form, often combined with Alpha-GPC and coffee, early in the day before workouts or concentrated mental work to increase dopamine transmission for concentration and focus.
    • 1 Oct 2026 · Tyrosine · neutral · Podcast ↗
      Discusses L-Tyrosine and its relation to dopamine, also mentioning combining tools.
    • 28 Sep 2026 · uses · YouTube ↗
      Mentions that coffee and tea produce caffeine, which were likely defense chemicals, and that plants learned it was better to alter consciousness than kill predators outright.
    • 28 Sep 2026 · uses · Podcast ↗
      Discusses caffeine and its health benefits.
    • 6 Aug 2026 · recommends · Podcast ↗
      Recommends caffeine as a tool to increase motivation and dopamine.
  • Dr. Rhonda Patrick · Caffeine · neutral
    • 26 Oct 2026 · neutral · Instagram ↗
      Explains that caffeine can activate AMPK, a cellular energy sensor involved in fat burning and glucose regulation, which helps muscle cells take up glucose and promotes using fatty acids for energy.
    • 2 Oct 2026 · recommends · YouTube ↗
      Recommends pairing caffeine with L-theanine to enhance alertness and focus while mitigating anxiety and jitteriness, suggesting a dose of 100 to 150 mg of caffeine.
    • 30 Sep 2026 · recommends · Facebook ↗
      Recommends pairing coffee with L-theanine to enhance cognitive performance, noting that L-theanine can help balance caffeine’s stimulatory effects.
    • 28 Sep 2026 · warns · YouTube ↗
      Recommends cutting out caffeine in the three months before conception for both men and women, as it affects sperm.
    • 14 Aug 2026 · recommends · Facebook ↗
      Recommends caffeine for alertness and focus, especially when combined with L-theanine to smooth out the response and maintain cognitive benefits, suggesting a practical dose of 100-150 mg.
    • 5 Jun 2026 · recommends · Instagram ↗
      Recommends cutting down or eliminating caffeine when actively trying to conceive.
    • 27 May 2026 · warns · Facebook ↗
      Warns that a very high dose of caffeine, around 350 mg pre-workout, may blunt some of creatine's performance benefit due to opposite effects on muscle relaxation.
    • 24 Mar 2026 · uses · YouTube ↗
      Self-administers 350 mg of caffeine in a bolus right after returning from mass and his workout, and before eating, noting that he likes dark roast Starbucks.
    • 6 Feb 2026 · neutral · Instagram ↗
      The newest literature on Caffeine dose and its link to multiple cardiometabolic disease risk reduction shows that even the ≥400 mg group was healthier than 0 mg.
    • 8 Oct 2025 · neutral · X ↗
      Explains that caffeine works by blocking adenosine, a molecule that builds up and makes one feel tired, and that timing coffee intake is about leveraging adenosine biology for peak cognitive alertness.
    • 2 May 2025 · Beta-alanine · recommends · Facebook ↗
      Recommends beta-alanine for boosting exercise performance, stating it allows one to push harder and longer by buffering muscle burn.
    • 30 Apr 2025 · Citrulline · neutral · Instagram ↗
      Supplements like beetroot juice or citrulline can help close that gap, providing both systemic and cerebral benefits through enhanced vascular function.
    • 29 Apr 2025 · Beta-alanine · neutral · Facebook ↗
      Lists beta-alanine as a supplement for enhancing exercise performance and recovery.
    • 29 Apr 2025 · Citrulline · recommends · Facebook ↗
      Recommends citrulline as a blood flow enhancer that boosts nitric oxide, opens up blood vessels, and can improve how one feels during endurance or high-rep sessions, also sharpening mental clarity.
  • Siim Land · Caffeine · recommends
    • 25 Oct 2026 · recommends · Instagram ↗
      Recommends stopping caffeine earlier to improve sleep.
    • 19 Oct 2026 · neutral · YouTube ↗
      Notes that polyphenolic compounds in coffee, both decaf and regular caffeinated, can influence cellular stress pathways and have been seen to increase autophagy activity in mice, with regular coffee appearing more potent due to caffeine's additional energetic stress.
    • 12 Oct 2026 · recommends · Instagram ↗
      Recommends moving caffeine intake earlier in the day because having it too late can disrupt sleep, especially for slow metabolizers.
    • 12 Oct 2026 · warns · YouTube ↗
      Recommends not having caffeine after lunch, noting that 400 mg 4 hours before bed reduced deep sleep by approximately 30 minutes in a trial, although he personally has a fast caffeine metabolism.
    • 28 Sep 2026 · warns · YouTube ↗
      Warns that combining a large dose of glycine with caffeine can amplify negative experiences, as caffeine independently increases arousal and can cause restlessness, anxiety, and increased heart rate.
    • 25 Sep 2026 · recommends · YouTube ↗
      States that regular coffee promotes visceral fat loss, and going from low or zero intake to moderate intake increases fat loss due to caffeine and polyphenols.
    • 23 Sep 2026 · Citrulline · neutral · YouTube ↗
      States that L-citrulline can raise arginine availability and support the conventional enzymatic pathway for nitric oxide production, which does not depend on mouth bacteria.
    • 15 Jun 2026 · recommends · YouTube ↗
      Suggests that higher caffeine intake might be useful for older people because caffeine raises cortisol, and consuming it in the morning contributes to circadian regulation.
    • 12 Jun 2026 · recommends · YouTube ↗
      States that caffeine has proven benefits for increasing exercise performance when used correctly and at the right time.
    • 7 Jun 2026 · neutral · X ↗
      States that caffeine raises blood pressure, but mostly if one is not used to consuming it, and habitual caffeine consumers develop tolerance to these effects.
    • 6 Jun 2026 · neutral · X ↗
      Quotes a tweet suggesting that without caffeine, civilization would be 100 years behind.
    • 28 Dec 2025 · Beta-alanine · recommends · YouTube ↗
      Places beta-alanine in the 'good tier', stating it's potentially useful for sports performance by buffering lactic acid and produces carnosine for skin anti-aging benefits, but notes it can cause skin itching.
    • 28 Dec 2025 · Citrulline · neutral · YouTube ↗
      Places Citrulline in the 'good' tier because this amino acid helps with nitric oxide production, thereby improving blood flow.
    • 18 Oct 2025 · Citrulline · recommends · YouTube ↗
      Suggests that citrulline, taken before a workout to increase blood flow, might also promote some of the benefits from the sauna.
  • Ben Greenfield · Caffeine · stopped
    • 24 Oct 2026 · stopped · Facebook ↗
      Came off caffeine for a year after his separation.
    • 24 Oct 2026 · stopped · Podcast ↗
      Quit caffeine in the same year he quit testosterone replacement therapy and alcohol.
    • 22 Oct 2026 · uses · YouTube ↗
      Uses caffeine, such as coffee or green tea, in his morning fasted fat-burning session to slightly increase the oxidation of fats.
    • 17 Oct 2026 · warns · YouTube ↗
      Advises against relying on caffeine for morning energy, suggesting that natural sugar-based stimulants combined with hydration and meditation can provide sufficient wakefulness.
    • 27 Sep 2026 · recommends · Facebook ↗
      Recommends Caffeine, noting that it can improve focus, mood, and training, help control appetite, raise calories burned, and reduce fatigue.
    • 27 Sep 2026 · Beta-alanine · recommends · Facebook ↗
      Recommends Beta-alanine, explaining it builds up carnosine in muscles, helping buffer acidity during hard efforts.
    • 18 Sep 2026 · neutral · X ↗
      Notes that 3 mg/kg of caffeine increases fat oxidation by 31%, and 5 mg/kg increases it by 51% compared to a placebo.
    • 16 Sep 2026 · neutral · X ↗
      Caffeine on its own isn’t particularly impressive as an ergogenic aid, but when combined with taurine, there are significant increases in power production.
    • 14 Sep 2026 · neutral · X ↗
      Mentions that caffeine can help mitigate the negative effects of a caloric deficit on lean muscle mass and metabolism.
    • 11 Sep 2026 · neutral · X ↗
      Has talked before about caffeine as a supplement that seems to assist with sleep deprivation.
    • 5 Sep 2026 · warns · X ↗
      Warns that energy drinks can deliver large doses of caffeine quickly, which may overstimulate the heart and cause abnormal heart rhythms and electrocardiogram changes, especially in children.
    • 23 Jul 2026 · Citrulline · recommends · YouTube ↗
      Recommends taking citrulline, a pre-workout that vasodilates, about 30 minutes before a sauna session to induce more sweating and aid in detoxification.
    • 3 Mar 2026 · Beta-alanine · recommends · Facebook ↗
      Recommends beta-alanine to enhance muscular endurance and improve buffering capacity during high-intensity efforts.
    • 17 Jan 2026 · Tyrosine · uses · YouTube ↗
      Started using the Balance Protocol supplement protocol to replete his tyrosine levels, which were inadequate for turning tyrosine into thyroid hormone, dopamine, norepinephrine, and epinephrine.
  • Dr. Mark Hyman · Caffeine · warns
    • 7 Oct 2026 · warns · YouTube ↗
      Discusses with patients their caffeine consumption, suggesting that too much caffeine can artificially increase their stress response.
    • 17 Sep 2026 · recommends · X ↗
      Recommends stopping caffeine by noon.
    • 31 Aug 2026 · neutral · YouTube ↗
      States that caffeine's effect on ADHD depends on the person, as it can help focus but also activate irritation or stress, and its impact is related to individual caffeine metabolism.
    • 20 Jul 2026 · warns · YouTube ↗
      Warns that drinking coffee first thing in the morning before eating layers caffeine on top of already elevated stress hormones, providing unsustainable energy and setting up for an afternoon crash.
    • 29 Jun 2026 · neutral · Facebook ↗
      Notes that caffeine is one of the things that drives the hormone imbalance causing PMS.
    • 1 Jun 2026 · warns · YouTube ↗
      States that drinking coffee on an empty stomach, which is how most people do it, is probably not the best thing as it gives a jolt of caffeine and adrenaline before eating.
    • 25 May 2026 · warns · YouTube ↗
      Warns that caffeine, alcohol, and spicy foods can be potent triggers for hot flashes, and excess caffeine should be avoided.
    • 21 May 2026 · warns · Facebook ↗
      Warns that adding fiber does not cancel out the negative effects of caffeine and other processed additives.
    • 18 May 2026 · warns · YouTube ↗
      Warns that high caffeine intake, especially coffee, can contribute to dehydration by increasing fluid loss and masking fatigue, leading to a deficit if not balanced with sufficient water intake.
    • 14 May 2026 · warns · Facebook ↗
      Warns that caffeine without adequate protein creates blood sugar chaos, sending a stress signal to the brain and hindering healing.
    • 6 Nov 2024 · Citrulline · neutral · YouTube ↗
      Mentions that athletic cocktails include amino acids like citrulline to help with recovery and improve physical performance.
    • 14 Aug 2024 · Tyrosine · neutral · YouTube ↗
      Mentions looking at tyrosine, which is connected with dopamine, norepinephrine, and epinephrine pathways.
    • 8 Mar 2024 · Tyrosine · recommends · YouTube ↗
      Recommends tyrosine for dopamine production, which can be obtained from grass-fed and regeneratively raised beef, lamb, fish, chicken, nuts, seeds, eggs, and beans.
    • 11 Jun 2022 · Tyrosine · uses · YouTube ↗
      Put a patient on L-Tyrosine, a precursor to dopamine, because he thought the patient had a dopamine deficiency.
  • Dr. Eric Berg · Caffeine · warns
    • 25 Sep 2026 · warns · Podcast ↗
      Warns that caffeine can keep you awake and advises to watch out for hidden sources of caffeine.
    • 14 Sep 2026 · warns · Facebook ↗
      Stimulating the body with caffeine can actually make fatigue worse.
    • 8 Sep 2026 · warns · Facebook ↗
      Dr. Berg warns that stimulating the body with caffeine can actually make fatigue worse.
    • 31 Aug 2026 · warns · Instagram ↗
      Warns that too much caffeine is a common cause of worry, indecision, fear, and tension, and that it depletes vitamin B1, negatively affecting the nervous system.
    • 3 Aug 2026 · warns · Facebook ↗
      Warns that even a lot of caffeine in the morning can inhibit melatonin at night.
    • 29 Jul 2026 · warns · Instagram ↗
      Warns that coffee does not give you energy; instead, caffeine binds to adenosine receptors, inhibiting sleep signals and merely preventing sleepiness.
    • 18 Jul 2026 · warns · Instagram ↗
      States that caffeine can affect the ability to absorb magnesium and cause a deficiency.
    • 12 Jul 2026 · warns · YouTube ↗
      Warns that drinking caffeinated beverages later in the day can keep you awake because the liver needs to detoxify the caffeine.
    • 25 Jun 2026 · warns · YouTube ↗
      Warns that consuming caffeine can worsen tinnitus, citing a person who noticed this effect.
    • 28 Apr 2026 · warns · Podcast ↗
      Stimulating the body with caffeine can actually make fatigue worse.
    • 13 May 2025 · Tyrosine · recommends · Podcast ↗
      Recommends foods high in L-tyrosine, such as meat, fish, eggs, and cheese, as it is a precursor to dopamine.
    • 12 May 2025 · Tyrosine · stopped · YouTube ↗
      Used to give L-tyrosine to people with ADHD to help with focus and calmness, but now recommends consuming foods high in L-tyrosine instead.
    • 28 Sep 2023 · Tyrosine · recommends · Podcast ↗
      Recommends getting plenty of tyrosine by consuming high-quality animal protein to help balance dopamine and other neurotransmitters naturally.
    • 6 Sep 2023 · Tyrosine · recommends · YouTube ↗
      Recommends tyrosine, an amino acid, as a cofactor that helps the production of dopamine, which can be obtained by consuming adequate good protein sources.
  • Bryan Johnson · Caffeine · uses
    • 23 Sep 2026 · uses · YouTube ↗
      Drinks coffee when starting to fade, ensuring the last cup is between 10 and 12 hours before bed so caffeine doesn't affect sleep.
    • 18 Jun 2026 · uses · X ↗
      Used 300 mg of caffeine in the morning as part of their jet lag recovery.
    • 7 Jun 2026 · uses · X ↗
      Uses 300 mg of slow release caffeine in the morning as part of a jet lag recovery protocol.
    • 25 Apr 2026 · neutral · X ↗
      Notes that coffee affects the gut, which then affects the brain, and that it is the coffee bean, not the caffeine, doing most of the work.
    • 19 Nov 2025 · warns · YouTube ↗
      Notes that the culture in DC involves running on caffeine, along with alcohol and sleep deprivation, leading to poor nutrition and an unhealthy environment.
    • 3 Jul 2025 · warns · YouTube ↗
      Warns that caffeine has a 6-hour half-life, so consuming it later in the day will leave a significant amount in the body at bedtime, recommending consumption earlier in the day.
    • 12 Apr 2025 · recommends · YouTube ↗
      Recommends consuming no caffeine past noon due to its 6-hour half-life, suggesting that if sleep is nailed, caffeine might not be needed.
    • 6 Nov 2024 · warns · YouTube ↗
      Warns against stimulants like caffeine for sleep, advising to have the last cup of coffee before noon if going to bed at 10:00 p.m.
    • 16 Oct 2024 · stopped · YouTube ↗
      Advises that if one is going to drink caffeine, they should try to have it earlier in the day and experiment to find the right time that doesn't disrupt their sleep.
    • 23 Mar 2024 · stopped · YouTube ↗
      Has stopped all caffeine, as it has helped him improve his sleep.
  • Peter Attia · Caffeine · uses
    • 16 Aug 2026 · uses · YouTube ↗
      States that he needs two to three times the normal dose of any medication or drug to feel an effect, including caffeine, and can drink four cups of coffee without feeling anything.
    • 4 Jan 2026 · neutral · YouTube ↗
      Mentions data suggesting caffeine might be more helpful in the luteal phase to help with fatigue components.
    • 4 Jan 2026 · Beta-alanine · uses · YouTube ↗
      Peter Attia, who did not believe in dietary supplements as a collegiate athlete, later dove into understanding the impacts of beta-alanine during grad school.
    • 12 Dec 2025 · uses · YouTube ↗
      Uses caffeine in combination with Alpha GPC, MCT, and Theanine, often adding it to coffee for long periods of cognitive work.
    • 7 Dec 2025 · uses · YouTube ↗
      Finds Alpha GPC works well with caffeine, and he puts a product containing Alpha GPC, MCT, and caffeine into his coffee for long periods of cognitive work.
    • 4 May 2025 · neutral · YouTube ↗
      Mentions that experimenting with the timing of caffeine is a great idea for sleep.
    • 27 Mar 2025 · warns · YouTube ↗
      Warns that decaffeinated coffee can contain significant amounts of caffeine and advises cutting off all coffee, including decaf, by 11 a.m. for better sleep quality.
    • 23 Mar 2025 · warns · YouTube ↗
      Explains that caffeine is problematic because it blocks adenosine receptors, leading to a 'caffeine crash' when it wears off and adenosine floods the receptors, causing sleepiness.
    • 10 Dec 2024 · neutral · YouTube ↗
      States that caffeine does not wake him up, which contributed to his belief that he did not have an addiction gene.
    • 14 Oct 2024 · neutral · YouTube ↗
      States that caffeine does not wake him up.
    • 10 Oct 2024 · warns · YouTube ↗
      Warns that constantly consuming caffeine and Red Bull to turn up the sympathetic dial is a sign that the sympathetic system isn't working as it should, possibly due to overstimulation from stress.
    • 25 May 2024 · Citrulline · recommends · YouTube ↗
      Recommends citrulline malate, stating it increases blood nitrate levels more than arginine due to better bioavailability, and can enhance performance and potentially stimulate mtor for hypertrophy.
    • 5 Jun 2023 · Tyrosine · neutral · YouTube ↗
      Considers tyrosine an interesting supplement that may be beneficial for improving reaction time, noting they tinkered with it a little bit.
    • 2 May 2022 · Citrulline · recommends · YouTube ↗
      Recommends citrulline malate or citrulline specifically, noting it increases blood nitrate levels more than arginine and is included in his pre-workout product, with a recommended dose of 6 to 8 grams.

RAL Summary

Members OnlyTier 2 for Energy

Beta-alanine at a full dose improved high-intensity exercise in a review of 18 trials [4], and caffeine reliably improves energy and endurance [2]. With 87% of 795 reviews positive, tier 2 is supported.

Where the evidence disagrees: 45 of the 154 human studies found no effect.

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Members OnlyBody systems · Combine with · Possible side effects

Body systems: Nervous system, Muscular system, Cardiovascular system

Combine with: If the goal is sexual function in men, stack ingredients with better evidence instead of relying on a pre-workout. L-citrulline (3-6 g daily) or L-arginine supports nitric oxide production and blood flow. Panax ginseng (Korean red ginseng) has clinical data for erectile function. Other options are Tongkat Ali or Fenugreek for hormonal and libido support, zinc and vitamin D if levels are low, and Maca for desire. Pair these with a heart-healthy lifestyle and consult a clinician about persistent erectile issues, especially if you take medication or have cardiovascular risk. If you keep using the pre-workout for training, keep caffeine moderate, avoid taking it late in the day so it doesn't disrupt sleep, and stay hydrated. Creatine monohydrate is a useful non-stimulant addition for muscle performance.

Possible side effects: In studies, L-theanine taken alone raised headache ratings, and very high daily caffeine doses worsened sleep and increased fatigue. Beta-alanine is known among buyers for a tingling feeling.

Supplement Facts

L-Citrulline Malate 6 g · Beta-Alanine 1.6 g · L-Tyrosine 500 mg
Supplement Facts
Serving Size 5.5-11 Gram(s)
Servings Per Container 30
Amount Per Serving% Daily Value
Sodium160 mg
L-Citrulline Malate6 g†
Beta-Alanine1.6 g†
L-Tyrosine500 mg†
Caffeine200 mg†
L-Theanine200 mg†
† Daily Value not established.

Other ingredients: Sodium Citrate, Natural Flavors, Silica, Sucralose, Acesulfame Potassium, Spirulina Extract.

Directions: Suggested Use: Mix 1/2 scoop in 6–8 fl oz water 20–30 minutes before your workout. Once tolerance has been assessed, you may take one full serving (1 scoop). A slight tingling sensation is normal and is due to the beta-alanine. Be sure to stay hydrated and have a great workout!

Barcode (UPC) 810030514817 · Label source: NIH label database · Report a label change

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Graded November 4, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.