Blackstone Labs PCT V Review
PCT V is sold by Blackstone Labs as a Post Cycle Therapy supplement designed to help protect gains and support natural hormone levels after an aggressive cycle. The page explains that rapid muscle and strength gains can disappear quickly, along with natural testosterone production, if proper post cycle therapy is not followed. Blackstone Labs positions PCT V as an all-in-one option meant to preserve gains, restore hormonal homeostasis, prevent testosterone suppression, and support the transition off cycle. The page states that no other post cycle therapy supplement is needed alongside it, and says it can also be used by natural competitors seeking an anabolic edge. The label lists five ingredients. Tribulus Terrestris at 250mg is described as increasing luteinizing hormone production, which supports natural testosterone production, and as helping to reduce stress and cortisol. Saw Palmetto at 160mg is described as helping to prevent dihydrotestosterone conversion, protecting the prostate and reducing hair loss risk. N-Acetyl Cysteine at 125mg is described as supporting glutathione production and as a liver protectant. Arimistane at 37.5mg is described as an aromatase inhibitor that keeps excess estrogen in check when coming off cycle, and as supporting natural testosterone production. 5-alpha-hydroxy laxogenin at 25mg is described as a plant a med that the page says increases muscle protein synthesis and has anti-catabolic effects through nitrogen retention and cortisol blunting. Directions say to take one capsule in the morning and one capsule in the evening, and not to exceed two capsules daily. The page lists supportive claims including post cycle therapy, supporting natural hormone levels, may support liver cleansing, and may support prostate health. These are the page's own claims and have not been independently verified here. The product is shown at $59.99 with a compare price of $74.99, marked 20 percent off, but the page displays it as sold out and the add to cart option is unavailable. The default title is the only variant shown. The product page also includes a Supplement Facts panel image. No barcode or serving count per container is printed in the text provided.
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Study, Trial or Testing Result Summary
Members Only44 human studies · 17 improved
Tribulus is at a full dose when three servings are taken, but the best evidence shows it does not reliably raise testosterone in men [1][2]. It may help erection scores without changing testosterone [3]. Trials in men with erection problems, infertile men and healthy young men found no hormone change [4][5][6]. Saw palmetto is at a full dose when two servings are taken. One trial of 99 men found that a sitosterol-enriched saw palmetto oil raised free testosterone and eased low-hormone symptoms [7]. Older work found 320 milligrams a day lowered the strong form of testosterone in prostate tissue [8], but another study found no change in blood levels after one week [9]. N-acetylcysteine is at 125 milligrams, below the 600 milligrams studied, and larger pooled analyses found it improved sperm but not testosterone [10][11]. Arimistane has no human studies, and the only research looked at a related compound in animals [12][13]. Alpha hydroxy laxogenin has no studies. Animal and cell studies are never counted.
See all 44 studies →Hide the studies
- Across 18 studies of 2185 women with polycystic ovary syndrome, N-acetylcysteine lowered total testosterone and raised follicle-stimulating hormone, but did not change progesterone, luteinising hormone, sex hormone-binding globulin, follicle number or endometrial thickness.The effects of N-acetylcysteine on ovulation and sex hormones profile in women with polycystic ovary syndrome: a systema…
- Across 14 trials of 1227 men with erectile dysfunction, herbal supplements overall raised erectile function and testosterone, but evidence for Tribulus terrestris specifically was judged insufficient.Herbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled tria…
- In a pooled analysis of 621 men with low sperm motility, N-acetylcysteine improved sperm measures but made no clear difference to testosterone, luteinizing hormone, follicle-stimulating hormone or prolactin compared with no treatment.A Meta-Analysis of the Efficacy of L-Carnitine/L-Acetyl-Carnitine or N-Acetyl-Cysteine in Men With Idiopathic Asthenozoo…
- In three randomised trials of 431 infertile men, daily N-acetylcysteine improved sperm count, volume, movement and shape but did not significantly change testosterone, luteinising hormone, follicle-stimulating hormone or prolactin versus placebo.The role of N-acetyl-cysteine (NAC) orally daily on the sperm parameters and serum hormones in idiopathic infertile men:…
- In eight trials of men with erectile dysfunction, Tribulus terrestris improved erectile function scores more than placebo, but total testosterone did not differ from placebo.Tribulus terrestris for management of patients with erectile dysfunction: a systematic review and meta-analysis of rando…
- In 10 trials comparing N-acetylcysteine with a med in women with polycystic ovary syndrome, N-acetylcysteine lowered body mass index and total testosterone, with no difference in pregnancy rate, luteinising hormone, fasting insulin or the luteinising to follicle-stimulating hormone ratio.Read the study on PubMed (31749393) →
- In seven randomised trials in men with unexplained infertility (three of N-acetylcysteine), the combined conclusion said both L-carnitine and N-acetylcysteine raised testosterone, but the detailed results showed only L-carnitine raised it, and neither changed other hormones.Meta-analysis of the efficacy and safety of L-carnitine and N-acetylcysteine monotherapy for male idiopathic infertility…
- In 10 trials with 483 men taking 400 to 750 mg daily for 1 to 3 months, Tribulus improved erectile dysfunction in 3 of 5 studies, but 8 of 10 showed no testosterone change, with small rises only in men with low testosterone.Effects of Tribulus (Tribulus terrestris L.) Supplementation on Erectile Dysfunction and Testosterone Levels in Men-A Sy…
- A review of 11 studies in healthy people and animals found Tribulus alone did not raise testosterone in humans, only within combined supplements.A systematic review on the herbal extract Tribulus terrestris and the roots of its putative aphrodisiac and performance …
- A review of 105 trials of ingredients in popular male testosterone and erectile supplements found limited evidence overall, with many ingredients including Tribulus among the commonly used.A systematic review and evidence-based analysis of ingredients in popular male testosterone and erectile dysfunction sup…
- A review of 52 studies of testosterone boosters found most, including Tribulus terrestris, failed to raise total testosterone compared with placebo.Do "testosterone boosters" really increase serum total testosterone? A systematic review.
- In 162 women with clomiphene-resistant polycystic ovary syndrome, 3 months of N-acetylcysteine improved follicle-stimulating hormone, luteinizing hormone and free testosterone, with a greater free testosterone improvement than l-carnitine.Randomized controlled trial of N-acetylcysteine versus l-carnitine among women with clomiphene-citrate-resistant polycys…
- In 100 women with polycystic ovary syndrome, 600 mg of N-acetylcysteine three times daily for 24 weeks lowered free testosterone, hirsutism, insulin and menstrual irregularity, with effects equal to a med.Read the study on PubMed (21831508) →
- In 99 men aged 40-65 with prostate enlargement, 500 mg a day of sitosterol-enriched saw palmetto oil for 12 weeks raised free testosterone and lowered androgen deficiency symptom scores compared with placebo.A double blind, placebo-controlled randomized comparative study on the efficacy of phytosterol-enriched and conventional…
- In 70 elderly men with low libido, a Tribulus-containing blend for 2 months raised total testosterone from 230 to 671 ng/dl while a med did not change it significantly.Read the study on PubMed (23173697) →
- In 70 aging men with low testosterone and erectile dysfunction, Tribulus three times daily for 3 months raised total testosterone and erectile function scores, with a small rise in liver enzyme and prostate antigen levels.Tribulus terrestris versus placebo in the treatment of erectile dysfunction and lower urinary tract symptoms in patients…
- In 55 men aged 30 to 58, a blend containing 1,350 mg of Tribulus terrestris plus androstenediol and other herbs taken for 4 weeks did not change total testosterone, though free testosterone rose 37% alongside increases in estradiol and dihydrotestosterone and a drop in HDL cholesterol.Endocrine and lipid responses to chronic androstenediol-herbal supplementation in 30 to 58 year old men.
- In 55 men aged 30 to 59, a blend containing 750 mg of Tribulus terrestris plus androstenedione and other herbs taken for 4 weeks left total testosterone unchanged, while free testosterone rose 38% and estradiol and dihydrotestosterone also rose and HDL cholesterol fell.Effects of androstenedione-herbal supplementation on serum sex hormone concentrations in 30- to 59-year-old men.
- In 50 infertile men with poor sperm shape and movement, taking 600 mg of N-acetyl-cysteine daily for 3 months raised sperm count and motility, lowered sperm DNA damage, and shifted hormone levels toward higher testosterone and lower FSH and LH compared with before treatment.Effects of N-acetyl-cysteine supplementation on sperm quality, chromatin integrity and level of oxidative stress in infe…
- In 44 men with prostate enlargement, a saw palmetto herbal blend for 6 months was only slightly better than placebo on symptoms (not significant) and the mechanism appeared non-hormonal.Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia.
- In 40 men with prostate enlargement, a saw palmetto herbal blend for 6 months lowered prostate tissue dihydrotestosterone by 32% with no significant change on placebo.Read the study on PubMed (11337315) →
- In 35 men with prostate enlargement, Serenoa repens extract for 3 months lowered nuclear estrogen and progesterone receptors in prostate tissue compared with placebo.Evidence that Serenoa repens extract displays an antiestrogenic activity in prostatic tissue of benign prostatic hypertr…
- In 30 men with erectile dysfunction (average age about 60), 800 mg of Tribulus terrestris daily for 30 days did not raise total testosterone or improve erectile function more than placebo.Tribulus terrestris versus placebo in the treatment of erectile dysfunction: A prospective, randomized, double blind stu…
- In 30 men with unexplained infertility taking 750 mg daily for 3 months, Tribulus terrestris did not change testosterone, luteinizing hormone or semen parameters.Prospective Analysis on the Effect of Botanical Medicine (Tribulus terrestris) on Serum Testosterone Level and Semen Par…
- In 30 trained male CrossFit athletes, 770 mg of Tribulus terrestris daily for 6 weeks raised testosterone compared with placebo and improved bench press, but did not change body composition or the other performance tests.The Effects of 6 Weeks of Tribulus terrestris L. Supplementation on Body Composition, Hormonal Response, Perceived Exert…
- In 22 elite male rugby league players doing heavy preseason training, 450 mg of Tribulus daily for 5 weeks did not change the urinary testosterone to epitestosterone ratio compared with placebo, and it added no extra strength or lean mass gains.The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason…
- In 21 healthy young men taking Tribulus terrestris extract for 4 weeks, testosterone, androstenedione and luteinizing hormone did not differ from placebo.The aphrodisiac herb Tribulus terrestris does not influence the androgen production in young men.
- In 20 healthy sedentary men, 2 weeks of a saw palmetto and astaxanthin blend (800 or 1200 mg a day) lowered blood DHT (and estradiol at 1200 mg) versus placebo, while the 38% rise in testosterone at 1200 mg was not statistically significant.Evaluation of Resettin® on serum hormone levels in sedentary males.
- In middle-aged men, a supplement containing 750 mg of Tribulus daily for 4 weeks raised serum free testosterone, estradiol and DHT, and it had minimal effect on immune function.Ingestion of a dietary supplement containing dehydroepiandrosterone (DHEA) and androstenedione has minimal effect on imm…
- In 108 clomiphene-resistant women with polycystic ovary syndrome, 1800 mg daily N-acetylcysteine for 12 weeks with clomiphene lowered hirsutism score and fasting blood sugar more than a med and raised ovulation and pregnancy rates; no differences were seen at 8 weeks.Read the study on PubMed (28698075) →
- In women with polycystic ovary syndrome, 24 weeks of 1,800 mg daily N-acetylcysteine was compared with a med; 45 women per group were evaluated, and the N-acetylcysteine group showed greater reductions in total testosterone and better insulin resistance markers.Read the study on PubMed (30814814) →
- In 37 women with polycystic ovary syndrome (6 obese ones on placebo), 5-6 weeks of 1.8 g daily N-acetylcysteine (3 g for massively obese) lowered testosterone and free androgen index and improved insulin sensitivity, mainly in women with high insulin.N-acetyl-cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome.
- In 32 healthy young men, Serenoa repens extract for 1 week had no effect on blood dihydrotestosterone, unlike a med, which cut it by about 52-65%.Read the study on PubMed (7805711) →
- In 20 young men taking a multi-ingredient supplement containing 750 mg Tribulus terrestris daily for 8 weeks with resistance training, free and total testosterone did not change compared with placebo.Effects of anabolic precursors on serum testosterone concentrations and adaptations to resistance training in young men.
- After 3 months of 320 mg daily saw palmetto extract, prostate tissue showed lower DHT and epidermal growth factor and higher testosterone compared with the untreated group.Effects of long-term treatment with Serenoa repens (Permixon) on the concentrations and regional distribution of androge…
- In 65 men with abnormal semen tests taking a 250 mg Tribulus extract capsule, dihydrotestosterone rose and body fat fell while lean mass and sperm concentration and motility improved, though the daily dose and duration were not stated.Effect of oral administration of Tribulus terrestris extract on semen quality and body fat index of infertile men.
- In 30 aging men with partial androgen deficiency taking 750 mg of Tribulus daily for 3 months, total and free testosterone and erectile function scores improved significantly.Pilot Study on the Effect of Botanical Medicine (Tribulus terrestris) on Serum Testosterone Level and Erectile Function …
- In 20 men with enlarged prostates taking 160 mg of saw palmetto extract twice daily for 30 days, blood testosterone and pituitary hormone levels did not change.Lack of effects of a lyposterolic extract of Serenoa repens on plasma levels of testosterone, follicle-stimulating hormo…
- In a small pilot of 8 male and 7 female recreational athletes taking a Tribulus extract for about two months, urinary a med hormone levels, including testosterone, did not change significantly compared with before supplementation.Read the study on PubMed (41005195) →
- In athletes taking Tribulus capsules three times a day for 20 days, blood testosterone rose during the first 10 days but did not keep rising in the second 10 days, and anaerobic power increased.The influence of the Tribulus terrestris extract on the parameters of the functional preparedness and athletes' organism…
- This study tested a different aromatase inhibitor, 1,4,6-androstatriene-3,17-dione, not this ingredient, in rats with depression-like symptoms; it did not improve depression-like behavior or corticosterone levels, though it raised testosterone, and it did not test androst-3,5-diene-7,17-dione in people.Aromatase changes in depression: A postmortem and animal experimental study.
- In castrated male Japanese macaques (animal study, about 5 per group) over about 3 months, testosterone raised serotonin-related gene activity and nerve fiber density, while dihydrotestosterone with aromatase blocking raised gene activity but lowered nerve fiber density, with no human outcome measured.Relationships between androgens, serotonin gene expression and innervation in male macaques.
- In castrated male Japanese macaques (animal study, about 5 per group) over about 3 months, converting testosterone to estrogen lowered brain enzyme activity linked to serotonin breakdown, while androgens raised a second such enzyme, with no human outcome measured.Androgen metabolites impact CSF amines and axonal serotonin via MAO-A and -B in male macaques.
- In two geldings (horses, not humans) given a single 800 mg dose of this aromatase inhibitor by stomach tube, urine testosterone rose, and the drug and its metabolites were traceable in urine for up to 77 hours and in blood for up to 28 hours.Metabolic study of androsta-1,4,6-triene-3,17-dione in horses using liquid chromatography/high resolution mass spectrome…
Review Totals and Summary
Members Only426 reviews · 95% positive
Blackstone Labs PCT V capsules get a strongly positive response, with about 193 ratings across the stores. Buyers mostly use them after a cycle to hold on to muscle, and the main complaints concern the company's marketing contact and shipping speed rather than the capsules themselves. Reviews of other forms of the product were left out, and several reviews that were really about local coffee and nutrition shops were not treated as feedback on this product. **What buyers say it did for them:** The most common theme is keeping gains after a cycle. One buyer calls it a "Topnotch pct for maintaining gains," and another takes it "during my off cycle so that I don't lose my muscle mass." Store summaries add that buyers feel it helps them keep gains and see "everything coming back nicely" in the early weeks after a prohormone cycle. One buyer says they could feel the effects. The reports are early-stage, and nobody describes long-term use. **What buyers complain about:** The one 3-star review says it is "Not a bad product," but objects to the company's marketing. After ordering, they say, they got calls and emails from many people, and they believe their information was passed to a third party, Legion, which pushes them to buy through it. A second complaint, from a 4-star buyer, is slow dispatch. The order shipped about four days after it was placed, despite site information suggesting faster, which delayed the start of their PCT. They advise ordering early. Nobody complains about the formula itself. Star counts on the two larger pages show a small number of 1-star ratings, but the reasons are not given. **Taste, smell, pill size, form:** The reviews and summaries say nothing about taste, smell, capsule size, or side effects, so there is no evidence either way. **Value for money:** Evidence is thin. One buyer describes the price as reasonable. Nothing else addresses value. **Who it seems to suit and who it didn't:** It appears to suit people finishing a cycle who want to protect what they built. Some buyers trust the brand, with one saying "they never fail me" before even trying it, though that is brand loyalty rather than experience. Buyers on a tight schedule should order well ahead, given the shipping delay reported. Anyone who dislikes follow-up sales calls and emails may be put off by the 3-star reviewer's experience. One reviewer praised fast shipping to a military location and some free extras, so delivery experience seems to vary by store. **Overall caution:** Written feedback is short and mostly general, with few details on how the capsules perform. The positive star ratings are a better guide to overall satisfaction than the written comments.
Biohacker Summary
Members Only7 of 10 recommend it
Eight of the ten panelists spoke about saw palmetto, the main ingredient, and opinion is mixed but leans positive: several recommend it, mostly as a natural blocker of the hormone DHT to help with hair loss and prostate health. Doses came up twice, at 300 to 400 mg a day from one panelist and about 300 mg a day split into two or three doses from another, with low side effects noted, and one suggested a topical form and one liked taking it during the eating window when fasting. Others stayed neutral, and one found it helped reduce grogginess when taken on waking. Cautions came from two panelists: one said it will not move the needle on hair loss driven by androgens, and another said high doses can be a problem for people whose DHT is already low; one also linked it to raised liver enzymes in a hair product with several botanicals and another said it may only block some forms of the enzyme involved. Tribulus is a smaller ingredient in this product, and most of the panel who mentioned it doubt it raises testosterone, with one advising to stop using it.
See all 8 biohackers →Hide the biohackers
Ben Greenfield · Saw Palmetto · neutral
- States Saw Palmetto Extract is traditionally used to support healthy hair growth by working against the hormone that drives thinning.
- Recommends saw palmetto at a dose of 300 to 400 mg per day to help lower DHT levels by causing 5-alpha reductase inhibition, particularly if hair loss is due to high DHT.
- Recommends Tribulus terrestris as a phenomenal herbal for women to naturally raise testosterone levels, particularly when prescription testosterone is not an option.
- Was advised to take saw palmetto extract to reduce grogginess from ketotifen, and he found that it actually works, reducing a lot of the grogginess when taken upon waking.
- Warns that Nutrafol, a hair growth supplement, has been linked to liver injury due to its botanical ingredients like Saw Palmetto, Ashwagandha, and Curcumin, which can elevate liver enzymes.
- Mentions Tribulus terrestris as an herb that seems to have an impact on testosterone.
- Recommends starting someone on Saw Palmetto first if they are already experiencing hair loss, especially thinning on the crown for women, to help with elevated DHT hair loss from testosterone.
- States that Tribulus Terrestris is a phenomenal herbal for raising natural testosterone levels in women.
- Doesn't think Tribulus has any peer-reviewed data behind it and believes it's part of a cyclical supplement industry where products are proven not to work, disappear, and then return as the 'next greatest thing'.
- Recommends Saw Palmetto Extract for bladder issues at night.
- Lists Tribulus Terrestris as an herbal add-on for testosterone.
- Recommends tribulus for significantly enhancing sexual drives and increasing actual libido, noting it is known as the goat head weed and has been shown to work in studies.
- Uses a little bit of tribulus in his 'cacao tropic mixture' elixir, which he takes for a natural nootropic effect.
- Recommends Tribulus to help with testosterone during the off-cycle from SARMs.
Dr. Eric Berg · Saw Palmetto · recommends
- Recommends topical saw palmetto, mentioning five clinical trials that showed positive results for hair regrowth.
- States that saw palmetto worked better than tamsulosin for lower urinary tract symptoms, reducing symptoms by 5.8 points compared to 5.2 points for the drug, with much less side effects.
- Recommends Saw Palmetto as a natural inhibitor of the five alpha reductase enzyme, which helps reduce DHT and has very few side effects for an enlarged prostate.
- Recommends saw palmetto as a natural 5 alpha-reductase inhibitor for hair loss.
- Advises avoiding tribulus for muscle building, as it increases testosterone but not enough to build muscle.
- Mentions phytoestrogens in saw palmetto as an example of plant-based estrogen compounds.
- Dr. Eric Berg's hair formula includes saw palmetto as an important ingredient for healthy hair.
- States that saw palmetto was added in some studies with gelatin and L-cysteine, noting it is good for the hormonal component of hair loss.
- Mentions saw palmetto as an herbal remedy that can interfere with the conversion of free testosterone to DHT.
- Recommends saw palmetto to inhibit the 5-alpha reductase enzyme, which helps reduce DHT and prevent prostate enlargement.
- Recommends saw palmetto as a great natural inhibitor of the 5-alpha reductase enzyme, with fewer side effects than drugs.
- Recommends tribulus, stating it's a natural compound that can increase follicle stimulating hormone, support pituitary and adrenal hormones, act as an adaptogen for stress, and provide energy.
- Mentions tribulus as another natural herb that can help increase testosterone.
Dr. Rhonda Patrick · Saw Palmetto · warns
- States that taking saw palmetto will not move the needle for inhibiting miniaturization mediated through androgens, which is the ultimate cause of hair loss.
- States that Tribulus, along with D-aspartic acid and fenugreek, has been disproven for its effects on testosterone.
Dave Asprey · Saw Palmetto · warns
- Has seen a number of guys who have taken Saw Palmetto in high doses, which can be problematic if they have low baseline DHT in the first place, as it suppresses the five alpha reductase pathway.
- Mentions tribulus as a supplement that can raise testosterone levels for libido.
- Suggests trying tribulus as an herbal step to optimize testosterone levels.
- Recommends saw palmetto as a natural way to block DHT for guys experiencing baldness or hair loss caused by DHT.
- Recommends saw palmetto as an antioxidant to ramp up catalase production.
Siim Land · Saw Palmetto · neutral
- Mentions Saw Palmetto as an herbal supplement that has been shown to increase testosterone, though not as effectively as TRT.
- States that Tribulus terrestris, a famous old-school testosterone booster, will not increase testosterone, citing a large meta-analysis.
- States that Tribulus terrestris and similar supplements do almost nothing.
- Warns that Tribulus terrestris, a known testosterone booster, has very weak evidence for its effects on testosterone, with most studies showing no significant increase or only a small increase in men with low baseline testosterone.
- Places Tribulus Terrestris in the 'junk tier', stating there is no evidence it increases testosterone levels or helps with erectile dysfunction.
- Warns against Tribulus Terrestris, calling it the most generic testosterone-boosting supplement with no evidence of increasing testosterone levels or helping with erectile dysfunction.
- Suggests combining creatine with things that lower DHT, such as saw palmetto, to enjoy the benefits of creatine while mitigating potential hair loss.
Andrew Huberman · Saw Palmetto · neutral
- Explains the effectiveness of saw palmetto in the context of 5-alpha reductase and hair loss.
- Discusses Tribulus as a supplement that may support a healthy libido.
- Recommends saw palmetto at about 300 milligrams per day, divided into two or three doses, to help hold onto hair and potentially grow new hair, noting its low side effects and logical mechanism of action.
- Andrew Huberman mentions saw palmetto as a 5-alpha reductase inhibitor, but notes it only inhibits a couple of the isoenzymes, which can be problematic.
- Notes that if there's a strong genetic predisposition to enlarged prostates or early, fast-growing prostate cancers, individuals could consider taking saw palmetto as an anti-androgen, if they can tolerate it.
- He recommends Tribulus terrestris, specifically the brand Momentous, at a dose of 600 milligrams daily, as a tool to increase libido and sex drive.
- Discusses Tribulus Terrestris, noting that while its effect on testosterone for fitness is unclear, some studies show it can increase free and bio-available testosterone in postmenopausal women and improve sexual desire and function in certain female populations.
- Andrew Huberman asks about saw palmetto and other supplements that support or cause issues for the prostate.
- Huberman mentions that saw palmetto is also a 5-alpha reductase inhibitor, but only for a couple of the isoenzymes, which is problematic.
- Mentions a double-blind study where taking 6 grams of Tribulus root for 60 days led to a clear and significant increase in libido and various aspects of sexual function.
Dr. Mark Hyman · Saw Palmetto · neutral
- Discusses Saw Palmetto as a five alpha ductase inhibitor, similar to spironolactone, often used for men's prostate but also given to women for similar effects.
- Recommends saw palmetto, an herb, for hormonal acne, particularly in women with PCOS, as it can block the conversion of testosterone to dihydrotestosterone.
- Recommends saw palmetto, an herb, as a natural version to mitigate DHT conversion and can be used topically or as an oil.
Thomas DeLauer · Saw Palmetto · recommends
- Highly recommends adding saw palmetto to the mix during the eating window, as it is widely known for helping with prostate issues and its impact is increased during this time due to fasting.
- Mentions that more tribulus could be beneficial for testosterone, but it's not working on the axis that most people need help with.
- Advises replacing tribulus with Tongkat Ali, stating that it has negligible impact on testosterone levels.
- Notes that Tribulus was hyped up and might do something if the saponin content is high enough and it's a high-quality product, but it might be a transient effect.
- Recommends saw palmetto for both men and women, noting its benefits for prostate support in men by slowing the conversion of testosterone to DHT, and also having benefits for women.
- Recommends Saw Palmetto to slow down the production of 5 alpha reductase, which in turn reduces the creation of DHT, thereby lessening its effect on hair follicles.
- Highly recommends using Tribulus in conjunction with other compounds and a balanced diet to get the most out of male life, noting it helps balance hormones in general and increases DHT and DHEA.
RAL Summary
Members OnlyTier 4 for Hormone Balance for Men
The Tier 2 grade rests on saw palmetto, but its largest positive trial used a sitosterol-enriched oil, another used a herbal blend, and other studies found no change in blood hormones, while Tribulus and N-acetylcysteine showed no hormone effect, so the evidence is thin and mixed. So it is graded Tier 4, lower than the rules alone gave.
Take 3 servings a day (3 capsules) to match the dose that worked in the studies.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 16 of the 44 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Endocrine system, Reproductive system
Combine with: For men seeking libido support, consider stacking with ashwagandha (KSM-66, 300-600 mg) to lower cortisol and support testosterone and sexual desire, Panax ginseng or maca root for sexual desire and performance, and fenugreek extract (e.g. Testofen) for libido and androgen support. Zinc (15-30 mg) and vitamin D3 (1,000-5,000 IU) with vitamin K2 correct common deficiencies that suppress testosterone, and boron (3-10 mg) may help free testosterone. L-citrulline or L-arginine can aid nitric oxide and blood flow for erectile quality. Saw palmetto or additional nettle root may complement prostate health. Anyone recently off a cycle of anabolic compounds should have bloodwork checked and consult a physician rather than relying on supplements alone.
Possible side effects: No major side effects reported. Some trials of blends mixing saw palmetto with hormone precursors found raised estrogen.
Supplement Facts
Tribulus terrestris std. extract 250 mg · Saw Palmetto berry extract 160 mg · NAC 125 mg
| Tribulus terrestris std. extract | 250 mg | † |
| Saw Palmetto berry extract | 160 mg | † |
| NAC | 125 mg | † |
| Androst 3,5-Dien-7,17-Dione | 37.5 mg | † |
| Alpha Hydroxy Laxogenine | 25 mg | † |
Other ingredients: Gelatin, Magnesium Stearate, Rice Flour.
Label source: NIH label database · Report a label change
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Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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