Thorne Advanced Testosterone Support Review
Advanced Testosterone Support is a capsule formula from Thorne designed to support the body's natural production of testosterone. The page explains that healthy testosterone levels are associated with several health benefits, including optimal sexual function, muscle health, healthy libido, and vitality. Thorne presents the product as a way to help men maintain mental and physical vigor. The page lists benefits such as maintaining a healthy body composition and lean body mass, healthy libido and sexual function, reduced muscle fatigue to make workouts more productive, improved endothelial function to support blood flow throughout the body, and optimal mental performance and positive mood. The page notes that testosterone levels start dropping naturally at about 1-2% a year in men between ages 30 and 40, and that total testosterone has declined over the past two decades, even among young men. It also lists common causes of low testosterone in men, including the natural aging process, overweight or obesity, stress, testing later in the day, medical conditions such as diabetes, kidney, and liver disease, and medications including meds, meds, meds, and opiates. The formula's key ingredients are shilajit extract at 500mg, luteolin phytosome at 150mg, ashwagandha extract from root and leaf at 120mg, and zinc as zinc bisglycinate chelate at 15mg. The serving size is 2 capsules and there are 30 servings per container. Shilajit is described as decomposed plant matter fermented by soil organisms, supplied as the trademarked PrimaVie ingredient, and said to contain urolithins, humic acids and minerals. Shoden ashwagandha is described as a high-potency extract containing 35% withanolide glycosides. Luteolin is described as a flavonoid with a structure similar to sex hormones, supporting a healthy ratio of testosterone to estrogen, and the phytosome form is said to enhance absorption. The zinc is described as bound to glycine for absorption and linked to testosterone and sperm production. The page states the product has a fully transparent label, uses purest possible ingredients in highly absorbable forms, and is made in the USA from U.S. and imported ingredients. Warnings state the product is contraindicated for anyone with a history of hypersensitivity to its ingredients, that pregnant or nursing women and women trying to conceive should not use it, and that there are no known adverse interactions or contraindications at publication date.
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Study, Trial or Testing Result Summary
Members Only32 human studies · 17 improved
The main support for this product comes from Shoden ashwagandha extract at 120 milligrams, a full dose. In a trial of 60 stressed adults, 60 or 120 milligrams daily for 60 days raised testosterone in men by 22 and 33 percent, against 4 percent on placebo [1]. In 57 overweight men aged 40 to 70, 8 weeks of Shoden gave a 14.7 percent greater testosterone rise than placebo [2]. A third trial at 240 milligrams found a rise that was not clearly better than placebo [3]. Shilajit at 500 milligrams is also a full dose. In healthy men aged 45 to 55, purified Shilajit twice a day for 90 days raised total and free testosterone more than placebo [4]. A review judged it possibly effective for men with low testosterone later in life [5]. Zinc is at 15 milligrams, below the 50 milligrams that worked in one dialysis trial [6]. Most zinc trials found no hormone change [7][8]. Luteolin has only animal evidence for male hormones [9]. Its one human study did not measure hormones [10]. Animal and cell studies are never counted.
See all 32 studies →Hide the studies
- In a pooled review of 15 trials of men and women with chronic kidney disease, oral zinc raised testosterone in one small study of 20 patients, but zinc added to dialysis fluid did not, and luteinizing and follicle-stimulating hormones did not change.Interventions for treating sexual dysfunction in patients with chronic kidney disease.
- In a pooled analysis of trials in sub-fertile men, folate plus zinc did not change blood testosterone compared with placebo, though it did improve sperm concentration and shape.The Effect of Folate and Folate Plus Zinc Supplementation on Endocrine Parameters and Sperm Characteristics in Sub-Ferti…
- In a review of 14 trials in people with chronic kidney disease, oral zinc improved testosterone but zinc added to dialysis fluid did not, and luteinizing and follicle-stimulating hormones were unchanged.Treatment options for sexual dysfunction in patients with chronic kidney disease: a systematic review of randomized cont…
- A review of 105 trials on ingredients in male testosterone and erectile supplements, including zinc, found limited evidence overall, with many ingredients having contradicting or lacking evidence.A systematic review and evidence-based analysis of ingredients in popular male testosterone and erectile dysfunction sup…
- A review of 52 studies of testosterone boosters, including 5 on zinc and magnesium, found that most supplements failed to raise total testosterone compared with placebo.Do "testosterone boosters" really increase serum total testosterone? A systematic review.
- In 47 fertile and 40 subfertile men given zinc sulphate with folic acid daily for 26 weeks, sperm concentration rose in subfertile men but testosterone and other hormones did not change compared with placebo.Does folic acid and zinc sulphate intervention affect endocrine parameters and sperm characteristics in men?
- In 60 stressed adults given 240 mg of Shoden ashwagandha extract daily for 60 days, testosterone rose in men over time but the change was not significantly different from placebo.An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A…
- In 60 stressed adults given 60 mg or 120 mg of Shoden ashwagandha daily for 60 days, testosterone rose 22% and 33% versus a 4% rise in men on placebo, a significant difference.Shoden promotes Relief from stress and anxiety: A randomized, double-blind, placebo-controlled study on healthy subjects…
- In 57 overweight men aged 40-70 with mild fatigue, 8 weeks of Shoden ashwagandha gave a 14.7% greater testosterone increase and 18% greater DHEA-S increase than placebo, though fatigue, vigor and sexual well-being did not differ.A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagand…
- In infertile men taking zinc 10 mg combined with D-aspartic acid and ubiquinol daily for 3 months, total testosterone and progressive sperm motility rose significantly compared with before treatment.Evaluation of in vivo supplementation of 2660 mg D-aspartic acid and 200 mg ubiquinol and 10 mg zinc on different semen …
- In 40 healthy adults aged 50-70 taking 400 mg a day of ashwagandha root extract for 180 days, testosterone rose 15.7% in men and the extract was well tolerated, with C-reactive protein falling 51.1%.Safety and Tolerability of Withania somnifera Root Extract in Healthy Male Participants: A Pilot Randomized, Double-Blin…
- In 20 men on hemodialysis, 50 mg of zinc daily for 6 months raised testosterone and sperm count and lowered luteinizing and follicle-stimulating hormones, with better libido and potency, unlike placebo.Effect of oral zinc therapy on gonadal function in hemodialysis patients. A double-blind study.
- In 18 male dialysis patients with sexual dysfunction and normal prolactin, oral zinc acetate for 6 months raised blood zinc but did not change testosterone, sex hormone binding globulin, gonadotrophins, sperm counts or erections compared with placebo; 1 of 9 on zinc reported better sexual function.Zinc deficiency and hyperprolactinaemia are not reversible causes of sexual dysfunction in uraemia.
- In 14 obese young men, 100 mg a day of zinc sulfate for one month raised zinc and leptin levels but did not change androgens or insulin sensitivity compared with placebo.[Effect of oral zinc administration on insulin sensitivity, leptin and androgens in obese males].
- In 14 men on kidney dialysis, 6 weeks of zinc chloride added to the dialysis fluid did not change testosterone, gonadotrophin levels or sexual function compared with placebo.Absence of a therapeutic effect of zinc in the sexual dysfunction of haemodialysed patients.
- In 8 dialysis men with low zinc, zinc given during dialysis improved potency in all four treated men and brought low testosterone back to normal in the two who had low levels, while placebo did not help.Reversal of uraemic impotence by zinc.
- After varicocele surgery, 6 months of zinc sulphate plus folic acid raised inhibin B and seminal antioxidant activity in men, while zinc alone or folic acid alone did not.Effect of folic acid and zinc sulphate on endocrine parameters and seminal antioxidant level after varicocelectomy.
- In healthy men aged 45 to 55, taking 250 mg of purified Shilajit twice a day for 90 days raised total testosterone, free testosterone and DHEAS more than placebo, while LH and FSH stayed steady.Clinical evaluation of purified Shilajit on testosterone levels in healthy volunteers.
- In overweight adults aged 40-75 taking 400 mg a day of ashwagandha extract for 12 weeks, men had significant rises in free testosterone and luteinizing hormone compared with placebo, though stress scores did not differ from placebo.Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in…
- In 11 young men fed controlled diets, 35 days on very low zinc (1.4 mg a day) lowered testosterone (26.9 to 21.9 nmol/L) and semen volume compared with 10.4 mg a day, showing testosterone drops when zinc is depleted.Effects of dietary zinc depletion on seminal volume and zinc loss, serum testosterone concentrations, and sperm morpholo…
- In men with liver cirrhosis and impotence or low sex hormones, zinc sulfate taken for 6 to 8 months did not work better than placebo, and testosterone levels did not change.Effect of the administration of zinc sulfate on hypogonadism and impotence in patients with chronic stable hepatic cirrh…
- In adult men with sickle cell anemia, oral zinc supplementation raised serum testosterone compared with placebo and corrected their androgen deficiency.Effect of zinc supplementation on serum testosterone level in adult male sickle cell anemia subjects.
- In 100 men on hemodialysis, 250 mg of zinc sulfate daily for 6 weeks raised testosterone and luteinizing hormone levels, though the authors judged the effect on sexual dysfunction unclear; there was no placebo group.Impact of oral zinc therapy on the level of sex hormones in male patients on hemodialysis.
- In 28 infertile men with low sperm counts who finished the trial, 200 mg a day of processed Shilajit for 90 days raised serum testosterone and sperm counts and lowered semen oxidative stress; there was no placebo group.Clinical evaluation of spermatogenic activity of processed Shilajit in oligospermia.
- In 25 healthy men taking 500 mg a day of Shilajit resin for 28 days, strength, endurance, VO2 max and C-reactive protein improved without a placebo group; the abstract does not report a change in testosterone.Safety and Efficacy of TruBlk™ Shilajit Resin Supplementation on Physical Performance and Blood Biomarkers in Healthy Ad…
- In 10 sedentary young men taking zinc sulfate at 3 mg per kg of body weight daily for 4 weeks, testosterone levels were higher after supplementation, and zinc appeared to prevent the drop in testosterone seen after exercise; there was no placebo group.Effect of fatiguing bicycle exercise on thyroid hormone and testosterone levels in sedentary males supplemented with ora…
- In 5 men with low-to-intermediate risk prostate cancer on active surveillance, 50 mg of oral luteolin daily for six months caused no side effects, and 2 of 5 men had a favorable biopsy response while 2 progressed and needed surgery.Preliminary Evidence on Safety and Clinical Efficacy of Luteolin for Patients With Prostate Cancer Under Active Surveill…
- In 14 regularly exercising men, a high-dose zinc-containing supplement raised blood zinc but did not change serum testosterone or testosterone metabolites in urine.Read the study on PubMed (17882141) →
- In male rats exposed to the insecticide abamectin for 70 days, a sage extract containing luteolin prevented drops in testosterone, luteinizing hormone and follicle-stimulating hormone. Luteolin was not tested alone, and this was an animal study with 36 rats.Salvia officinalis aqueous extract mitigates abamectin-induced testicular dysfunction in rats by targeting oxidative str…
- In male rats exposed to 900 MHz radiation from phones, luteolin raised serum testosterone and testis weight and protected Leydig cells and sperm-producing cells compared with radiation alone. This was an animal study with 24 rats and no dose stated in the abstract.Protective effects of luteolin on rat testis following exposure to 900 MHz electromagnetic field.
- In male rats given chemotherapy and radiation, a basil extract (200 mg/kg daily) containing a small amount of luteolin raised testosterone and restored testicular structure. Luteolin was not tested alone, and this was an animal study.Phytochemical profile and protective effect of Ocimum basilicum aqueous extract in doxorubicin/irradiation-induced testi…
- In female rats with polycystic ovary syndrome induced by letrozole and a high-fat diet, luteolin injections brought luteinizing hormone and testosterone back toward normal levels and raised estradiol and reduced follicle-stimulating hormone. This was an animal study in females, not men.Luteolin alleviates polycystic ovary syndrome in rats by resolving insulin resistance and oxidative stress.
Review Totals and Summary
Members Only1,122 reviews · 84% positive
Across the stores, Thorne Advanced Testosterone Support capsules carry about 880 ratings, and the picture is mixed but leans positive. Many buyers report more energy and focus, while a smaller group notice nothing and say the price is too high. This summary covers the capsules only; reviews of other forms were left out. **What buyers say it did for them:** The most common report is more energy and focus, often with better workouts. Some feel it quickly, others only after weeks. One buyer wrote "Within 4 days... you really notice a difference." Another said "Feel way better than before, every man should try." A more measured reviewer saw "a subtle boost in energy and focus" within a couple of weeks and called it no "magic fix." One buyer on a Dutch-language store also reports better sleep, and another reports deeper sleep and a bigger appetite. One reviewer says a blood test before and after showed a benefit after 90 days. **What buyers complain about:** The main complaints are no noticeable effect and slow results. One reviewer says it "didn't increase energy levels or make any real difference." Another needed about a month to feel anything. A buyer on iHerb couldn't tell any difference after almost a full bottle. One three-star reviewer reported a drop in libido and apathy on days six and seven of a trial, suspected ashwagandha as the cause, and called it a dealbreaker. Another reviewer wished the milligram amounts were higher. One iHerb reviewer mentioned an aftertaste. **Taste, smell, pill size and form:** Reviewers describe the capsules as easy to take. One says they have "no unpleasant taste or smell," and another says "no bad taste." The single aftertaste complaint is the exception. No reviewer raises pill size as a problem, and one reports no side effects. **Value for money:** Opinions split. Critics say the price is high for the bottle size, and one hopes Thorne will offer "bigger packages with a better price." Another calls it "quite disappointing given the high price." Others are happy: one says it is a quality product at an affordable price, and another says the bottle size is enough. One enthusiastic buyer would "buy it again no matter the cost." **Who it seems to suit and who it did not:** It seems to suit people who want a gradual, supportive boost and trust Thorne's reputation for quality and clean ingredients. Reviewers also mention it works best alongside sleep, diet and training, and many are regular supplement users or trainers. It suited others less: buyers expecting fast or dramatic change, those who weigh price heavily, and the person who felt a libido drop. One Dutch reviewer takes two capsules in the morning on an empty stomach, because otherwise they sleep poorly. That differs from the page's suggested one capsule twice a day. Another cut from two capsules a day to one to manage hunger.
Biohacker Summary
Members Only10 of 10 recommend it
Shilajit, the main ingredient, gets a split verdict from the panel: three of the seven who spoke about it recommend it, one uses it, two are neutral, and one stopped. Those who recommend it point to antioxidant benefits, help recovering from stress, and human data on testosterone and male fertility, with one citing 250 milligrams twice a day. The one who uses it adds a pinch to a favorite drink, while the neutral voices say the human trial evidence is thin, mostly animal studies, and that careful sourcing matters. One panelist tried about 20 kinds and felt nothing, so he stopped. Zinc is a smaller ingredient in this product, and the panel mostly recommends it, with doses of 15, 30, and 40 to 60 milligrams mentioned, and a few note it helps testosterone mainly when zinc is low.
See all 10 biohackers →Hide the biohackers
Ben Greenfield · Shilajit · recommends
- Recommends Shilajit, mentioning Organifi gummies, for its antioxidant and mineral chelating properties, citing human trials showing increases in sperm count, motility, and testosterone.
- Ben Greenfield's formulation includes 30 grams of zinc a day, taken for one week before surgery and two weeks after, as it is an important cofactor for wound healing.
- Emphasizes that zinc sufficiency is crucial for immunity because the thymus-derived peptide thymulin, which trains lymphocytes, requires zinc to be active.
- He mentions shilajit as a supplement with real human data behind it for male fertility.
- Recommends adding zinc into one's stack because it is a co-factor for enzymes involved in testosterone synthesis and sperm maturation, and zinc deficiency is a reproducible cause of low sperm count.
- He mentions zinc as a supplement with real human data behind it for male fertility.
- Zinc may support both testosterone and sperm count.
- Warns that he was taking so much zinc without realizing it because it was in five different things he was taking, and he couldn't pinpoint the problem.
- Recommends supplementing with zinc if deficient, as multiple trials show significant symptom reduction of tinnitus in zinc-deficient individuals.
- Notes a new study indicating that zinc is a core dietary antioxidant closely associated with a reduced risk of accelerated biological aging.
- Recommends using hormone building blocks like zinc for hormone optimization.
- Uses Shilajit to increase luteinizing hormone and FSH levels, which subsequently brings up testosterone, finding it beneficial for muscle and performance.
- Advises taking the GI Repair Formula away from food for best results, unless zinc causes nausea.
- Has found that adaptogens like shilajit, taken about half an hour before using the Shift Wave, seem to enhance its effects on tuning up the nervous system.
Siim Land · Shilajit · neutral
- States that Shilajit, a popular supplement for testosterone, lacks very good human controlled trials for increasing testosterone, with evidence mostly based on animal studies and anecdotal experience.
- States that deficiencies in nutrients such as zinc can impair normal immune regulation.
- Explains that zinc raises testosterone only if zinc status or testosterone levels are low, and can reduce the duration and severity of colds and flu, and lower blood sugar and lipids if zinc status is low.
- States that fixing zinc deficiency can double testosterone if low testosterone is due to zinc deficiency.
- States that zinc has strong evidence for increasing testosterone, but only if one has low zinc status.
- States that zinc deficiency is observed in children with premature graying of hair.
- Warns that supplementing 250 mg of zinc sulfate, which provides 55 to 60 mg of elemental zinc, is above the tolerable upper limit and can cause side effects like reduced copper absorption, anemia, immune dysfunction, GI stress, abdominal pain, diarrhea, and a metallic taste.
- States that clinical trials suggest shilajit helps with fatigue and energy, and may modestly increase testosterone levels, placing it in the 'good tier' while emphasizing the importance of source.
- States that zinc helps with immunity, wound healing, and testosterone levels, acknowledging its importance as a mineral and placing it in the 'good tier' despite not personally finding much value from it.
- Used to take zinc in the past but no longer does, as he has already tested most supplements.
- Recommends Shilajit as a rising star in testosterone boosting, with clinical trials suggesting it helps with fatigue and energy and modestly increases testosterone levels.
- Discusses Shilajit as a supplement.
- Recommends Zinc, acknowledging its importance as a mineral for immunity, wound healing, and testosterone levels, especially for those with low zinc.
- Discusses Zinc as a supplement.
Thomas DeLauer · Shilajit · recommends
- Recommends Shilajit, a Himalayan resin, to help recover and adapt to stress, reducing the impact of higher cortisol.
- Adds zinc to their immunity duo because it helps them absorb vitamin C, considering the two together a fantastic combination for fall and winter.
- Recommends zinc, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
- Mentions that more zinc could be beneficial for testosterone, but it's not working on the axis that most people need help with.
- Compares zinc content, noting salmon has under 1mg while oysters have 74mg per 100g, a 70x difference.
- Recommends keeping zinc levels topped off because it is a critical cofactor for over 300 enzymes and is important for immune cells, testosterone, and wound healing.
- Recommends 15 mg of supplemental zinc if oysters are not realistic, but emphasizes that food source zinc is better as it comes with natural cofactors like copper and selenium.
- Recommends getting zinc, along with vitamin D, magnesium, and calcium, from foods like sardines, as they are important for inflammatory pathways in the gut.
- Explains that zinc is a structural cofactor for an enzyme crucial in testosterone production, and a marginal deficiency is a reversible cause of suppressed testosterone. He recommends getting zinc through pumpkin seeds.
- Explains that zinc is a required cofactor for the 5-alpha reductase enzyme, which converts testosterone into its more potent form, DHT, and that zinc deficiency can impair this conversion.
- Recommends ensuring adequate zinc intake for skin healing and immune response, especially for heavy sweaters or those consuming high phytate foods.
- Recommends shilajit, a Himalayan resin, as one of the most effective cortisol-lowering and energy-supporting tools he has seen, suggesting viewers watch a dedicated video on it.
- Recommends Shilajit, a Himalayan resin, at 250 to 500 milligrams per day to help the body adapt to stressors, build resilience, and get stronger at dealing with stress.
- Mentions luteolin as an ingredient in Verso's Clean Being, highlighting its potent anti-inflammatory and antioxidant effects.
Dr. Rhonda Patrick · Shilajit · neutral
- Mentions that Shilajit might do something for testosterone by providing potent antioxidants, but it requires careful sourcing and is more speculative and indirect, as there are probably better ways to manage antioxidant profiles.
- Notes that not getting enough zinc can affect testosterone, as zinc is very important for testosterone synthesis.
- Recommends men take a 30 milligram zinc supplement for sperm health when preparing for IVF.
- Discusses findings from a meta-analysis on zinc supplementation, noting it improved insulin resistance, inflammation, and oxidative stress in people with diabetes or prediabetes, and explains its biological role in the pancreas.
- Recommends nutrients like zinc for men to prioritize sperm mitochondrial health.
- Recommends Zinc, stating it is a critical mineral required for testosterone production and that supplementation corrects deficiency-related low testosterone.
- Recommends correcting deficiencies in zinc to directly increase total testosterone by up to 100+ ng/dL.
- Recommends focusing on zinc to optimize testosterone and hormone health generally, noting that it supports luteinizing hormone production, which stimulates testosterone synthesis and conversion to dihydrotestosterone.
- Recommends zinc as one of the most reliable natural supplements for boosting testosterone if one is deficient, noting it's part of the ZMA combination.
- Recommends increasing intake of zinc if one regularly drinks alcohol.
- States that zinc is crucial for alcohol metabolism and that higher intakes might correlate with less severe hangover symptoms, also noting that alcohol increases zinc excretion, so replenishing zinc stores while consuming alcohol is important.
- Dr. Patrick discusses luteolin, a flavonoid in celery and parsley, which decreases inflammation by reducing the expression of inflammation-related genes and has been linked to decreased cancer incidence and slowed cognitive decline.
- Recommends luteolin for its neuroanti-inflammatory effects and potential to improve sense of smell, advising to take it with a fatty meal to significantly improve its low bioavailability.
- Takes Autophagy Renew for its luteolin content, which helps with lowering neuroinflammation.
Andrew Huberman · Shilajit · uses
- He usually adds a pinch of Shilajit to his favorite drink.
- Zinc carnosine to support and improve the lining of your gut.
- Notes that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
- States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
- Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
- States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut, and he was already taking some of these ingredients separately.
- States that AG1 Pro includes zinc carnosine, which he was already taking separately, to support and improve the lining of the gut.
- Personally takes zinc carnosine, which is included in AG1 Pro to support and improve the lining of the gut.
- AG1 Pro has zinc carnosine to support and improve the lining of your gut. Some of these ingredients I personally was already taking separate from the AG1 formula.
- States that AG1 Pro contains zinc carnosine to support and improve the lining of your gut.
- Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
- States that shilajit is on the low end of the effectiveness scale for increasing testosterone and that there are far better ways to support hormones, and he personally wouldn't place it high on any list of supplements to consider.
- Has played around with Shilajit, sometimes getting the sense it was having an effect, but then he would stop taking it for long periods of time.
- Huberman discusses Shilajit, an Ayurvedic herb, noting one study showing increases in FSH with its use, but expresses caution due to difficulty in distinguishing quality sources and dosing.
Dr. Mark Hyman · Shilajit · recommends
- Recommends Shilajit, an Ayurvedic compound, stating it increases libido, is a great antioxidant, helps blood flow and sexual performance, prevents premature ejaculation, and maintains erection, with a study showing 250 milligrams twice a day improved testosterone levels.
- Gave a patient with psoriatic arthritis a little zinc, which contributed to significant improvement in her condition.
- Recommends ensuring adequate zinc intake on a regular basis for immune support, noting some data on zinc lozenges for early cold.
- Recommends correcting nutrient deficiencies with zinc.
- Recommends nutrient-dense foods rich in zinc, such as pumpkin seeds and oysters, to reduce inflammation.
- Used zinc as part of a protocol to rebuild the gut microbiome and heal the gut of a nine-year-old girl with severe behavioral issues.
- Notes that zinc supports immune health, helps wounds heal, and plays a key role in growth and tissue repair, and they measure it.
- Mentions zinc is needed for phase one liver functions and inflammation.
- Notes that birth control drains zinc.
- Recommends zinc for immune system support and modulation.
- Relies on Big Bold Health's HTB Immune Energy Chews, which deliver 1000mg of sprouted Himalayan tardy buckwheat, along with vitamin C, D, magnesium, and zinc, to support immune balance, resilience, energy, and focus.
- Mentions luteolin, another flavonoid, which when combined with quercetin, has particular benefits for brain fog and neuroinflammation.
- Recommends focusing on foods naturally rich in luteolin, such as olive oil, greens, cauliflower, and blueberries, and also adding luteolin supplements, due to their natural a med qualities.
- Takes Luteolin as one of the more interesting supplements for aging.
Dave Asprey · Shilajit · stopped
- Has known about shilajit for a long time and has tried about 20 different kinds, but it has never done anything for him other than taste weird.
- Developed a nonnano zinc sunscreen over five years, stating her skin is probably better now than it's ever been.
- Emphasizes the importance of having enough zinc before trying advanced longevity strategies like peptides.
- Suggests that zinc has better safety and protective data than meds for reducing cardio respiratory risk.
- Advises that if someone has a goal, they should probably do simple things like getting more zinc if it helps their goal before using peptides.
- Recommends zinc for muscle and bone formation, stating that without it, the body cannot effectively build muscle and bone even with exercise and protein intake.
- Dave Asprey mentions zinc as a supplement and cofactor that supports thyroid activation.
- Recommends zinc as a cofactor that can help thyroid function, especially with conversion issues.
- Argues that if you are lacking zinc, ESS60 will not work as well.
- Recommends adequate zinc for healthy DHT signaling.
- States that he genetically needs a ton of zinc for his mitochondria to work, and if he doesn't take enough, his mitochondria don't work.
- Dave Asprey mentions that supplements like luteolin rival pharmaceuticals in keeping uric acid under control.
- States that luteolin, a bioflavonoid, targets the xanthine oxidase enzyme almost as effectively as allopurinol, and he personally takes 100 milligrams a day.
- Dave discusses shilajit, noting that it is similar to humic and fulvic mineral complexes, but its mineral composition varies greatly depending on its source.
Dr. Eric Berg · Zinc · recommends
- Recommends ensuring sufficient zinc intake because the prostate needs enough zinc for the conversion from testosterone to DHT to be smooth and optimized.
- Recommends taking zinc carnosine for an ulcer or some type of gastric problem.
- Emphasizes the importance of zinc for decreasing viral replication and recommends taking 40 to 60 mg every single day.
- Notes that birth control pills deplete the body of zinc, which is needed for the brain to make serotonin.
- Added zinc to his creatine product because a deficiency in zinc might make creatine not work as well.
- Mentions that grass-fed liver is loaded with zinc.
- Recommends zinc to enhance testosterone.
- Highly recommends taking at least 50 mg of zinc at the first sign of a cold.
- Recommends a new product called black elderberry with added zinc and vitamin D, which combines four essential immune support nutrients, and advises taking three per day with meals.
- Recommends ensuring enough zinc intake because vitamin A, which can help with dry mouth, doesn't work without it.
- States that Luteolin combined with PEA can support nerve tissue directly and target inflammation.
Bryan Johnson · Zinc · uses
- Takes 15 mg of Zinc in the morning for longevity.
- Takes 15 mg of Zinc in the morning.
- Takes 15 mg of Zinc in the morning for longevity.
- Bryan Johnson's baseline measurements showed low zinc, which was easy to fix by adjusting her protocol and supplements.
- Recommends adequate Zinc for hair health, noting it is in the Blueprint stack.
Peter Attia · Zinc · recommends
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Discusses the AREDS formula, which initially included C and beta-carotene with zinc and copper, and later replaced beta-carotene with lutein and zeaxanthin, showing it could delay or reduce the conversion of mild to severe macular degeneration.
- Explains that for Wilson's syndrome, which can lead to liver failure, the treatment given to children is zinc, which is inexpensive and effective in outcompeting copper to prevent overload.
- Uses a new irrigant called ZinC and Gent because they are very worried about prosthetic infection.
- Discusses the AREDS formula, which includes C, E, beta-carotene, zinc, and copper, and later lutein and zeaxanthin instead of beta-carotene. Studies showed it could delay or reduce the conversion of mild to severe macular degeneration but had no effect on severe disease or preventing it in healthy individuals.
- Mentions that a survey of doctors showed they recommend Zinc for COVID-19, but notes there is no real evidence behind it.
- Mentions zinc pyrithione as a treatment protocol for dandruff, which addresses malassezia yeast overgrowth in the scalp.
RAL Summary
Members OnlyTier 2 for Hormone Balance for Men
Placebo-controlled trials of Shoden ashwagandha at this dose raised testosterone in men, and purified Shilajit did the same at a full dose. Over 1,100 reviews are 84 percent positive.
Where the evidence disagrees: 9 of the 32 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Endocrine system, Reproductive system
Combine with: For men using this product, it pairs well with vitamin D3 and K2 (vitamin D status correlates with testosterone), magnesium glycinate (supports sleep and testosterone-related recovery), boron, and ashwagandha (may lower cortisol and support testosterone). Omega-3 fatty acids and resistance training support overall hormonal and cardiovascular health. Zinc is already included, so pair it with copper if taking additional zinc long term. Women seeking hormone support should instead consider options such as vitex, magnesium, B6, omega-3s, or DIM with guidance from a clinician.
Possible side effects: The studies report that ashwagandha and luteolin were well tolerated. One reviewer reported lower libido and apathy, and another mentioned an aftertaste.
Supplement Facts
Zinc 15 mg · Shilajit Extract 500 mg · Luteolin Phytosome 150 mg
| Zinc | 15 mg | |
| Shilajit Extract | 500 mg | † |
| Luteolin Phytosome | 150 mg | † |
| Shoden | 120 mg | † |
Other ingredients: Hypromellose, Microcrystalline Cellulose, Calcium Laurate, Leucine.
Directions: Suggested use: Take 2 capsules daily or as recommended by your health-care practitioner.
Barcode (UPC) 693749015093 · Label source: NIH label database · Report a label change
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Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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