Caltrate 600+D3 Review

Caltrate 600+D3 is presented on this page as a product that offers the highest level of vitamin D3 to help maximize calcium absorption and support healthy bones, joints and muscles. The page states that sufficient calcium and vitamin D as part of a healthy diet may reduce the risk of osteoporosis. It explains that calcium not only nourishes the bones but also plays a role in nerves, hormones, muscles and teeth. The page lists advanced levels of vitamin D3 in Caltrate as helping to maximize calcium absorption and maintain healthy bones. For suggested use, adults are told to take one tablet up to two times daily with food or as directed by a physician, with a full glass of water. The page says the product is not formulated for use in children, should not be exceeded beyond suggested use, and that anyone who is pregnant, nursing, or taking medication should consult a doctor before use. It advises keeping the product out of reach of children. A link to the product labeling PDF is provided. The page also lists other Caltrate products, including Gummy Bites, 600+D3 Soft Chews, 600+D3 Plus Mineral Mins, 600+D3 Plus Minerals and 600+D3 Plus Minerals Chewables, which are separate products with their own forms. No price, ingredient list, barcode, or customer review data appears in the scraped text, so those fields are left empty. The page includes a call to action to find where to buy the product and to get coupons, along with a story section about calcium needs at every age.

Product Focus: Bone HealthAlso covers:Hormones
Tier ⓘ
Tier 2 · Rank 24
Tier 2 · Researched. Human studies show improvement in an aging-related function or a specific goal, and the reviews agree. Rank 24 within Tier 2 for Bone Health; 24 of 45 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
84 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
95% of 17,338
Biohacker Mentions
8 of 10
Cost per month
$3

Study, Trial or Testing Result Summary

Members Only60 human studies · 28 improved
60 human studies28 improved15 no effect95,451 people studied

This product itself was tested in 35 human studies.

Several trials of this calcium and vitamin D tablet found bone density gains. In older Chinese women with low bone mass, one tablet daily for a year raised spine bone density by about 0.8 percent [1]. In people with osteoporosis, 600 milligrams daily for 12 weeks raised bone density [2], and older people recovering from hip fractures saw spine and hip gains over a year [3]. In young twin girls, 1200 milligrams of calcium carbonate daily raised hip and spine density for 12 to 18 months, but the gain was gone by 2 years [4]. Results are not consistent. In women just past menopause, the tablet alone showed small bone losses that were not significant over 2 years [5], and a 30 day trial found no change [6]. Vitamin D here is at a full dose. At 700 to 800 units a day it cut hip fractures by 26 percent in older adults [7], though another review found no clear drop in fractures [8]. A large review of calcium plus vitamin D in women with osteoporosis found a modest gain in pelvic bone density but not spine or hip, and no fewer fractures [9]. Older calcium trials found bone mineral stayed stable or unchanged [10][11]. Animal and cell studies are never counted.

See all 60 studies →Hide the studies

Review Totals and Summary

Members Only17,338 reviews · 95% positive
17,338 reviews · Amazon 16,944 · Walmart 164 · CVS 147 · Walgreens 83
95% positive3% neutral2% negative

Caltrate 600+D3 tablets are well liked overall, with most buyers rating them 4 or 5 stars. The product carries about 17,338 ratings across the stores. Buyers mostly praise it as a trusted, affordable calcium and vitamin D supplement, and the main complaints are tablet size and short expiry dates on some orders. **What buyers say it did for them:** Many describe it as a dependable bone-health supplement they have taken for years. One says it "keeps my bones healthy and strong," another "normalized my calcium," and a third simply says "Works well. Have used for years." Several mention that a doctor recommended it. One buyer credits it for surviving three falls without a broken bone. Store summaries also mention that it meets calcium and vitamin D needs and is a practical way to support bone health. **What they complain about:** The most specific complaints concern short-dated stock. One buyer received a package "only 3 months out," another got two bottles that were too close to expiring, and a third reported "Expires April and May 2024." One reviewer speculated that a heavily discounted item would be short dated. A single reviewer received a bottle sent without a cap. One store summary notes a one-star review objecting to the Red 40 Lake dye and to the manufacturer named on the bottle. Another review simply asks "why are the tablets pink?" **Taste, smell, pill size and form:** Size is the most mixed point. Many call the tablets easy to swallow: "I prefer the Caltrate calcium, it is very easy to swallow." Others find them big: "Big pills, but easy to swallow." One says "My only problem is how large they are," and a store summary mentions a one-star review from someone who could not swallow them at all. Two reviewers say the tablets can be cut in half, one of them preferring that to "chalky tasting gummies." One says it is "not too big and only have to take 2." A store summary says the tablets leave no aftertaste. **Value for money:** Price is a frequent positive. Reviewers write "Great price. Great brand," and "cheaper than what I was paying in the store." A Canadian buyer finds it a "real deal" compared with the smaller bottles sold locally. Another says it is a "Great Price!!" for a supplement they take every day. Store summaries also describe it as affordable and good value, and some praise fast, intact delivery. **Who it seems to suit and who it did not:** It suits people who want a familiar, doctor-recommended calcium plus D3 tablet at a low price and who can manage a large pill, or who are willing to split it. Long-term users cite brand trust: "its a brand i trust." It suits less well anyone who struggles with large tablets, avoids synthetic dyes, or buys online and needs a long shelf life, since several buyers received stock close to expiry. This summary covers the tablets only. Any reviews of other forms were left out.

Biohacker Summary

Members Only8 of 10 recommend it
8 of 10 biohackers on our panel recommend it

On calcium, the main ingredient, the panel is mostly neutral rather than enthusiastic: three of the ten recommend it, six are neutral and one warns. Those who recommend it say it matters for bone, nerves, muscles and the heart, and one suggests 1,000 to 1,200 milligrams a day, which can come from calcium carbonate or calcium citrate. Several others mainly point to food sources such as dairy, sardines and kale, or note that diets often fall short on calcium, and one is still weighing whether he needs a supplement. The one caution is that bone loss cannot be fixed with calcium alone, because bone also depends on collagen and other minerals. Vitamin D is a smaller ingredient in this product, and the panel speaks of it warmly, with several taking 5,000 IU a day or more and many urging that blood levels be checked.

See all 10 biohackers →Hide the biohackers
  • Dr. Eric Berg · Calcium · warns
    • 25 Oct 2026 · warns · YouTube ↗
      Warns that bone loss cannot be fixed with just calcium, as bone is primarily collagen with other essential minerals.
    • 2 Nov 2026 · Vitamin D · warns · Facebook ↗
      Dr. Berg warns that the recommended daily intake for vitamin D is based on a massive error and that the actual necessary amount is closer to 8,895 IU, with millions remaining deficient.
    • 31 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends getting vitamin D levels tested to ensure they are between 50 and 70, as vitamin D is intimately involved in regulating prostate size.
    • 30 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends taking at least 10,000 IUs of vitamin D3 every single day in the winter, stating it is the most important vitamin to lower cancer risk.
    • 30 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends vitamin D to support the immune system, aiming for blood levels between 80 to 100 ng per ml.
    • 25 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends taking no less than 10,000 IU's of vitamin D3 for osteoporosis, alongside magnesium and K2.
    • 25 Oct 2026 · Vitamin D · recommends · X ↗
      Recommends increasing vitamin D to restore balance and support healthy blood pressure.
    • 24 Oct 2026 · Vitamin D · neutral · YouTube ↗
      States that a lack of vitamin D can potentially cause achy bones or crashing mood.
    • 23 Oct 2026 · Vitamin D · recommends · YouTube ↗
      States that vitamin D is intimately involved in the immune system and recommends taking at least 10,000 IUs each day.
    • 21 Oct 2026 · Vitamin D · recommends · YouTube ↗
      States that taking high doses of vitamin D3 for 14 days can improve mood, sleep, low back pain, skin issues, and blood pressure, as well as act as a natural anti-inflammatory and reduce susceptibility to sickness.
    • 18 Oct 2026 · Vitamin D · neutral · YouTube ↗
      Mentions that grass-fed liver has vitamin D.
    • 10 Oct 2026 · warns · Podcast ↗
      Dr. Berg includes calcium carbonate among the synthetic supplements to avoid.
    • 3 Oct 2026 · warns · YouTube ↗
      Warns against calcium carbonate, also known as limestone, stating that while it lowered hip fractures in a study, it also increased kidney stones and is not good for arteries, requiring the body to work hard to use it.
    • 27 Sep 2026 · neutral · X ↗
      Notes that tannins in tea bind calcium, blocking its absorption.
  • Siim Land · Calcium · neutral
    • 30 Sep 2026 · neutral · X ↗
      Lists dairy and sardines as sources of Calcium.
    • 31 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Advises against taking vitamin D in the morning with other supplements because it is fat soluble and requires dietary fat for better absorption.
    • 29 Oct 2026 · Vitamin D · recommends · Instagram ↗
      Recommends taking Vitamin D with fat for better absorption.
    • 24 Oct 2026 · Vitamin D · neutral · Instagram ↗
      States that Vitamin D connects biology to light and that UVB reaching the skin enables its production.
    • 6 Sep 2026 · Vitamin D · recommends · Instagram ↗
      Thinks vitamin D has some of the strongest evidence and is worth considering.
    • 6 Sep 2026 · Vitamin D · neutral · X ↗
      Notes that Vitamin K2 pairs well with vitamin D by regulating calcium and bone mineralization.
    • 26 Aug 2026 · Vitamin D · recommends · Instagram ↗
      Recommends taking vitamin D supplements with some fat to maximize its absorption, suggesting with food or a teaspoon of olive oil.
    • 23 Aug 2026 · Vitamin D · neutral · X ↗
      Notes that taking vitamin D3 with a fat-containing meal resulted in 32% higher peak blood vitamin D levels.
    • 17 Aug 2026 · Vitamin D · recommends · X ↗
      Recommends taking Vitamin D in the morning or at lunch with fat.
    • 14 Aug 2026 · neutral · X ↗
      Notes that Boron reduces calcium/magnesium loss.
    • 14 Aug 2026 · Vitamin D · neutral · X ↗
      Notes that Boron improves vitamin D.
    • 5 Aug 2026 · Vitamin D · recommends · YouTube ↗
      Recommends Vitamin D because microglia contain Vitamin D receptors, and Vitamin D helps keep the immune system properly regulated, with low levels associated with greater neuroinflammation and a higher risk of autoimmune conditions.
    • 14 Feb 2026 · recommends · TikTok ↗
      Recommends a high calcium intake for bone health.
    • 28 Dec 2025 · warns · YouTube ↗
      Places calcium supplementation in the 'bad tier' due to its association with increased cardiovascular events, recommending dairy or bones as easier ways to get calcium, though it can be useful for postmenopausal women with low bone density.
  • Thomas DeLauer · Calcium · neutral
    • 18 Sep 2026 · neutral · Facebook ↗
      Notes that milk contains 120mg of calcium, while sardines contain 351mg, highlighting a 3x difference.
    • 23 Oct 2026 · Vitamin D · uses · YouTube ↗
      Uses vitamin D3 in the fall and winter months when getting less sun, as it's important to supplement it then.
    • 20 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends taking a massive amount of vitamin D simultaneously with an early morning massive breakfast to help reset circadian rhythms and address hyperphagia.
    • 8 Oct 2026 · Vitamin D · recommends · Facebook ↗
      Recommends Vitamin D, stating that it has receptors throughout the brain and deficiency can quickly impact brain and mood.
    • 6 Oct 2026 · Vitamin D · uses · YouTube ↗
      Takes supplemental vitamin D because he is skin sensitive and from northern latitudes, limiting his UV exposure.
    • 5 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends taking vitamin D on non-liver days to ensure both nutrients get proper receptor access.
    • 29 Sep 2026 · Vitamin D · uses · YouTube ↗
      Takes Purity's liquid vitamin D3 with K2 because she is constantly inside during the day; D3 is for overall wellness and K2 helps the body absorb calcium properly.
    • 11 Sep 2026 · Vitamin D · recommends · YouTube ↗
      Recommends getting vitamin D, suggesting it can be obtained while walking.
    • 6 Sep 2026 · Vitamin D · recommends · Instagram ↗
      States that vitamin D is best obtained from the sun, but getting it from food definitely helps, and notes its role as a hormone influencing many cells.
    • 1 Sep 2026 · Vitamin D · recommends · Instagram ↗
      Recommends D3, suggesting a dose of 2000-4000 IU, and notes that MK-7 slowed bone loss over three years.
    • 24 Aug 2026 · Vitamin D · recommends · YouTube ↗
      Recommends vitamin D, especially for Hashimoto's, explaining that it drives T reg expansion to suppress autoimmune responses that attack the thyroid, and notes that vitamin D and selenium deficiencies often co-occur.
    • 12 Aug 2026 · recommends · YouTube ↗
      Recommends getting calcium, along with vitamin D, zinc, and magnesium, from foods like sardines, as they are important for inflammatory pathways in the gut.
    • 30 Jun 2026 · neutral · YouTube ↗
      Explains that eating sardines with their soft bones provides a serious hit of calcium, which is a perfect combination for bones and may contribute to satiety.
    • 19 Jun 2026 · neutral · YouTube ↗
      Mentions that magnesium and calcium should not be taken together as they cancel each other out.
  • Dr. Mark Hyman · Calcium · recommends
    • 20 Aug 2026 · recommends · YouTube ↗
      Notes that calcium is in bones but is also essential for nerves, muscles, and the heart, and low levels can affect muscle function and heart rhythm.
    • 26 Oct 2026 · Vitamin D · recommends · Facebook ↗
      Recommends Vitamin D for health, stating that amazing things happen when patients' vitamin D statuses reach optimal levels.
    • 21 Oct 2026 · Vitamin D · neutral · YouTube ↗
      Mentions vitamin D as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
    • 19 Oct 2026 · Vitamin D · neutral · YouTube ↗
      Notes that vitamin D plays a role in immune function.
    • 8 Oct 2026 · Vitamin D · recommends · Instagram ↗
      Recommends checking vitamin D levels and states that if they had to pick one single intervention for immune health, vitamin D would be it.
    • 7 Oct 2026 · Vitamin D · neutral · Podcast ↗
      Dr. Hyman discusses vitamin D in relation to sun exposure patterns.
    • 7 Oct 2026 · Vitamin D · recommends · YouTube ↗
      States that vitamin D supplementation can help with oxidative stress.
    • 5 Oct 2026 · Vitamin D · neutral · Podcast ↗
      Mentions vitamin D as a key nutrient for supporting immune function.
    • 5 Oct 2026 · Vitamin D · recommends · YouTube ↗
      States that vitamin D is probably the single most important intervention for immune health, recommending levels of 45 to 70 and emphasizing testing to determine the right dose.
    • 30 Sep 2026 · Vitamin D · neutral · YouTube ↗
      Notes that rickets, which causes terrible bone deformities, is caused by vitamin D deficiency.
    • 21 Sep 2026 · Vitamin D · neutral · YouTube ↗
      Notes that vitamin D is an important nutrient for brain performance and aging, and that many people have gaps in these nutrients.
    • 17 Jun 2026 · neutral · YouTube ↗
      States that green leafy vegetables are great sources of calcium.
    • 3 Nov 2025 · neutral · Podcast ↗
      Notes that calcium needs are lower than advertised and that stress, soda, and excess sugar can drive calcium loss.
    • 17 Sep 2025 · warns · YouTube ↗
      Does not prescribe calcium supplements at all, teaching people to get it from whole foods instead, because calcium supplements don't work for building bones or preventing fractures, and it's bone quality, not density, that matters.
  • Dr. Rhonda Patrick · Calcium · neutral
    • 29 Jun 2026 · neutral · Facebook ↗
      Mentions that kale delivers calcium, a micronutrient many diets fall short on.
    • 5 Oct 2026 · Vitamin D · neutral · Facebook ↗
      Vitamin D supplementation was linked to a 40% lower risk of dementia in an observational study of more than 12,000 older adults.
    • 30 Sep 2026 · Vitamin D · recommends · YouTube ↗
      Mentions that vitamin D also plays a role in maintaining muscle mass.
    • 28 Sep 2026 · Vitamin D · recommends · YouTube ↗
      Recommends ensuring adequate vitamin D intake for men's sperm health.
    • 24 Sep 2026 · Vitamin D · neutral · Facebook ↗
      Vitamin D and strength training alone did not, but adding them strengthened the effect on one clock, with the full combination slowing that measure by ~3.8 months.
    • 25 Aug 2026 · Vitamin D · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 28 Jul 2026 · Vitamin D · recommends · Facebook ↗
      Recommends Vitamin D, noting it regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity, and correcting deficiency may slow epigenetic aging.
    • 22 Jul 2026 · Vitamin D · neutral · YouTube ↗
      Uses Vitamin D3 as an example of a supplement that an AI model could track to see its impact on other metrics like glucose levels.
    • 26 Jun 2026 · Vitamin D · recommends · Facebook ↗
      Recommends Vitamin D, explaining that it regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity.
    • 15 Jun 2026 · Vitamin D · neutral · Instagram ↗
      Combining omega-3s with vitamin D and exercise has an additive effect, translating to ~3 months of slowed biological aging.
    • 11 Jun 2026 · Vitamin D · neutral · Facebook ↗
      The effect got stronger when omega-3 was combined with vitamin D and resistance training, with the full stack delaying phenotypic aging by about 3.8 months.
    • 9 Jan 2026 · neutral · Facebook ↗
      Notes additional gaps in calcium.
    • 3 Jul 2024 · warns · YouTube ↗
      Reports that alcohol use disorder is associated with a 20-50% greater prevalence of Calcium deficiency.
    • 9 Oct 2015 · neutral · YouTube ↗
      Around 38% doesn't meet the requirement for calcium.
  • Dave Asprey · Calcium · neutral
    • 16 Jun 2026 · neutral · Facebook ↗
      Notes that when energy intake is too low for training demand, nutrient intake often falls short, especially for calcium, which is associated with reduced bone health.
    • 1 Nov 2026 · Vitamin D · uses · Facebook ↗
      Takes Vitamin DAKE from Suppgrade Labs.
    • 25 Oct 2026 · Vitamin D · recommends · Podcast ↗
      Suggests that vitamin D supports brain health, muscle function, and focus.
    • 9 Oct 2026 · Vitamin D · recommends · Podcast ↗
      Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense for male fertility, even though supplementation did not improve overall semen parameters in a randomized trial.
    • 7 Oct 2026 · Vitamin D · uses · YouTube ↗
      States that currently, he is only taking vitamin C and vitamin D.
    • 5 Sep 2026 · Vitamin D · recommends · YouTube ↗
      Recommends vitamin D, noting it's actually a hormone and that most people are deficient, even those who take it, because they don't take enough.
    • 3 Sep 2026 · Vitamin D · recommends · YouTube ↗
      States that most people on the spectrum are low in vitamin D and need more of it, mentioning his own product, Vitam DAKNE, which contains real vitamin A.
    • 29 Aug 2026 · Vitamin D · recommends · YouTube ↗
      Dave Asprey recommends Vitamin D3 with K2, explaining D3 is a hormone made from sunlight and K2 directs calcium into bones, not arteries, highlighting its low cost, widespread deficiency, and the ability to test its effectiveness.
    • 18 Aug 2026 · Vitamin D · recommends · YouTube ↗
      Recommends Vitamin D as one of the most important supplements for overall health.
    • 12 Aug 2026 · Vitamin D · uses · Facebook ↗
      Takes Vitamin DAKE from Suppgrade Labs because D3, A, K2, and E work together.
    • 28 Jul 2026 · Vitamin D · uses · YouTube ↗
      Mentions taking vitamin D in the morning, comparing it to the daily dosing of testosterone.
    • 12 Jun 2026 · neutral · Instagram ↗
      Explains that calcium provides the raw material for bones, but it isn't a standalone input and needs a whole system to be effective.
    • 12 Jun 2026 · neutral · X ↗
      Notes that people take calcium for their bones.
    • 14 May 2026 · warns · YouTube ↗
      Warns that taking calcium without vitamin D, A, and K2 can lead to calcium going into tissues, causing bone spurs and other issues, and recommends a two-to-one ratio of calcium to magnesium.
  • Ben Greenfield · Calcium · neutral
    • 9 May 2026 · neutral · YouTube ↗
      Is considering whether he needs a calcium supplement because lead can displace calcium in bones, affecting bone strength.
    • 29 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Notes that Vitamin D is actually a hormone and recommends patients aim for levels around 40 to 50, or even 60 for fracture healing, for optimal healing, as opposed to just above 20 which is considered normal.
    • 15 Oct 2026 · Vitamin D · recommends · Podcast ↗
      Mentions vitamin D as part of a bare-minimum protocol.
    • 15 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Advises getting vitamin D levels between 60 and 100 nanograms per milliliter as a minimum step for overall health and to slow down heart disease.
    • 20 Aug 2026 · Vitamin D · uses · YouTube ↗
      Has been taking Vitamin D3 K2 for over a decade.
    • 8 Aug 2026 · Vitamin D · neutral · Instagram ↗
      Notes that sunlight influences more than just vitamin D production.
    • 8 Aug 2026 · Vitamin D · recommends · YouTube ↗
      Recommends keeping vitamin D levels high, suggesting that a supplement is probably not a bad idea, especially given that many people are deficient due to spending most of their time indoors.
    • 18 Jul 2026 · Vitamin D · recommends · YouTube ↗
      Recommends getting enough vitamin D for blood pressure management.
    • 9 Jul 2026 · Vitamin D · recommends · YouTube ↗
      Recommends optimizing vitamin D levels to a serum score of around 50 to 80 nanograms per milliliter, as deficiency is linked to tinnitus volume and can assist with it.
    • 7 Jun 2026 · Vitamin D · recommends · Facebook ↗
      Recommends using hormone building blocks like vitamin D for hormone optimization.
    • 6 May 2026 · neutral · X ↗
      Mentions calcium as a common deficiency.
    • 6 May 2026 · Vitamin D · neutral · X ↗
      Notes that vitamin D deficiency is the most common deficiency.
    • 12 Apr 2026 · recommends · Facebook ↗
      Recommends adequate intake of calcium for bone strength.
    • 13 Feb 2026 · uses · YouTube ↗
      Is using calcium chloride mixed with PRP before injecting for the P-shot.
  • Peter Attia · Calcium · recommends
    • 9 Jul 2025 · recommends · YouTube ↗
      Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
    • 4 Jan 2026 · Vitamin D · uses · YouTube ↗
      Lists vitamin D as one of her staple supplements.
    • 16 Nov 2025 · Vitamin D · neutral · YouTube ↗
      Notes that several studies show patients taking vitamin D can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
    • 6 Aug 2025 · Vitamin D · neutral · YouTube ↗
      States that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin D for both sexes.
    • 3 Aug 2025 · Vitamin D · neutral · YouTube ↗
      Uses vitamin D as an example of how people might dismiss its efficacy due to failed clinical trials that didn't adjust the dose or measure levels.
    • 20 Jul 2025 · Vitamin D · neutral · YouTube ↗
      In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin D for both sexes.
    • 10 Jul 2025 · Vitamin D · neutral · YouTube ↗
      Suggests that supplementing with lots of vitamin D might help overcome the negative effects of phenytoin on bone health by improving calcium absorption, though he is unaware of studies on this.
    • 9 Jul 2025 · Vitamin D · recommends · YouTube ↗
      Recommends Vitamin D3 as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 800 to 1,000 IU, which can be obtained through sunlight or supplementation.
    • 6 Jul 2025 · neutral · YouTube ↗
      Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
    • 6 Jul 2025 · Vitamin D · neutral · YouTube ↗
      Suggests that supplementing with lots of vitamin D might overcome the negative effects of phenytoin on bone health by counteracting increased catabolism of vitamin D and subsequent decreased calcium absorption.
    • 8 Jun 2025 · Vitamin D · recommends · YouTube ↗
      Recommends vitamin D for people who tend to be vitamin D deficient, such as those living in Portland, Oregon.
    • 17 Mar 2025 · Vitamin D · neutral · Instagram ↗
      Discusses evaluating vitamin D, understanding deficiency, and optimal levels.
    • 22 Oct 2024 · recommends · YouTube ↗
      Recommends calcium for bone health, stating that teenagers probably need about 1000 milligrams a day.
    • 21 Oct 2024 · recommends · YouTube ↗
      Discusses bone acting as a reservoir for calcium and how resorption and formation release calcium into the blood when needed.
  • Bryan Johnson · Calcium · recommends
    • 5 Jun 2025 · recommends · YouTube ↗
      Recommends calcium as a mineral that, along with phosphorus, magnesium, and boron, is deposited to fortify the bone structure after the collagen scaffold is in place.
    • 22 Oct 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 15 Aug 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 3 Jul 2026 · Vitamin D · neutral · X ↗
      Mentions that the sunlight assessment claims low vitamin D levels cause the immune system to misfire, and notes that their vitamin D has been measured.
    • 4 May 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for longevity.
    • 2 May 2026 · Vitamin D · uses · X ↗
      He takes 5000 IU of Vitamin D3 in the morning for general health.
    • 21 Apr 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 15 Apr 2026 · Vitamin D · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning for longevity.
    • 14 Apr 2026 · Vitamin D · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning.
    • 8 Apr 2026 · Vitamin D · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning.
    • 7 Apr 2026 · Vitamin D · uses · X ↗
      He takes 5000 IU of Vitamin D3 in the morning for general health.
    • 12 May 2025 · recommends · YouTube ↗
      Agrees that a little extra calcium is probably okay, especially for women, to really hit home for bone mineral density.
    • Date not recorded · recommends · Website ↗
      Recommends prioritizing calcium intake for postmenopausal women to help maintain bone density and reduce the risk of osteoporosis.
    • Date not recorded · uses · Website ↗
      Bryan Johnson takes Calcium daily as part of his Longevity Mix, which supports healthy bones and teeth.
  • Andrew Huberman · Calcium · neutral
    • 6 Mar 2023 · neutral · Podcast ↗
      Discusses "hard water" and the role of magnesium and calcium in cardiovascular health.
    • 21 Sep 2026 · Vitamin D · neutral · YouTube ↗
      Notes that most people are probably deficient in vitamin D and benefit from supplementing, but there's no point in doing it unless you're deficient for most things.
    • 7 Aug 2026 · Vitamin D · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning for longevity.
    • 20 Jul 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 20 Jul 2026 · Vitamin D · recommends · YouTube ↗
      States that Vitamin D is one of the critical nutrients with the best evidence for cognitive function and reducing the risk of dementia.
    • 13 Jul 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning.
    • 12 Jul 2026 · Vitamin D · uses · X ↗
      He takes 5,000 IU of Vitamin D3 in the morning for overall health.
    • 6 Jul 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning.
    • 22 Jun 2026 · Vitamin D · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning for general health.
    • 17 Jun 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 every day for longevity.
    • 6 Jun 2026 · Vitamin D · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning.
    • Date not recorded · recommends · Website ↗
      Adequate intake of calcium is vital for bone health.

RAL Summary

Members OnlyTier 2 for Bone Health

Multiple controlled trials of this exact product show bone density gains in older adults and people with osteoporosis [1][3], and 95 percent of over 17,000 reviews are positive, meeting tier 2.

This product itself was tested in 35 human studies.

Where the evidence disagrees: 15 of the 60 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Skeletal system, Endocrine system

Combine with: For bone health, pair Caltrate 600+D3 with vitamin K2 (MK-7) to help direct calcium into bone rather than soft tissue, and magnesium (glycinate or citrate) to support calcium metabolism and vitamin D activation. Take it with meals, since calcium carbonate needs stomach acid for absorption, and separate it from iron, meds, and some meds by a few hours. Collagen peptides or boron may add further skeletal support. If blood sugar support is the actual goal, choose a separate product with berberine, chromium picolinate, or alpha-lipoic acid, and consult a healthcare provider, especially if taking meds.

Possible side effects: No major side effects reported in the studies; some buyers find the tablets large and hard to swallow, and one objected to the red dye.

Supplement Facts

Vitamin D3 800 IU · Calcium 600 mg
Supplement Facts
Serving Size 1 Tablet(s)
Amount Per Serving% Daily Value
Vitamin D3800 IU
Calcium600 mg

Other ingredients: Calcium Carbonate, Maltodextrin, Contains Less Than 2% of.

Directions: Suggested use: Adults: Take one (1) tablet up to two times daily with food or as directed by your physician. Take with a full glass of water.

Label source: NIH label database · Report a label change

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Our articles on this subject

Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.