Caltrate 600+D3 Review
Caltrate 600+D3 is presented on this page as a product that offers the highest level of vitamin D3 to help maximize calcium absorption and support healthy bones, joints and muscles. The page states that sufficient calcium and vitamin D as part of a healthy diet may reduce the risk of osteoporosis. It explains that calcium not only nourishes the bones but also plays a role in nerves, hormones, muscles and teeth. The page lists advanced levels of vitamin D3 in Caltrate as helping to maximize calcium absorption and maintain healthy bones. For suggested use, adults are told to take one tablet up to two times daily with food or as directed by a physician, with a full glass of water. The page says the product is not formulated for use in children, should not be exceeded beyond suggested use, and that anyone who is pregnant, nursing, or taking medication should consult a doctor before use. It advises keeping the product out of reach of children. A link to the product labeling PDF is provided. The page also lists other Caltrate products, including Gummy Bites, 600+D3 Soft Chews, 600+D3 Plus Mineral Mins, 600+D3 Plus Minerals and 600+D3 Plus Minerals Chewables, which are separate products with their own forms. No price, ingredient list, barcode, or customer review data appears in the scraped text, so those fields are left empty. The page includes a call to action to find where to buy the product and to get coupons, along with a story section about calcium needs at every age.
We don’t sell supplements. We help you make decisions and get the best price.
Lowest prices
Finding the lowest prices at the stores now. This takes a few seconds.
Products with nearly the same formula (Matched on the main ingredients)
Study, Trial or Testing Result Summary
Members Only60 human studies · 28 improved
This product itself was tested in 35 human studies.
Several trials of this calcium and vitamin D tablet found bone density gains. In older Chinese women with low bone mass, one tablet daily for a year raised spine bone density by about 0.8 percent [1]. In people with osteoporosis, 600 milligrams daily for 12 weeks raised bone density [2], and older people recovering from hip fractures saw spine and hip gains over a year [3]. In young twin girls, 1200 milligrams of calcium carbonate daily raised hip and spine density for 12 to 18 months, but the gain was gone by 2 years [4]. Results are not consistent. In women just past menopause, the tablet alone showed small bone losses that were not significant over 2 years [5], and a 30 day trial found no change [6]. Vitamin D here is at a full dose. At 700 to 800 units a day it cut hip fractures by 26 percent in older adults [7], though another review found no clear drop in fractures [8]. A large review of calcium plus vitamin D in women with osteoporosis found a modest gain in pelvic bone density but not spine or hip, and no fewer fractures [9]. Older calcium trials found bone mineral stayed stable or unchanged [10][11]. Animal and cell studies are never counted.
See all 60 studies →Hide the studies
- In 11 trials of 43,869 postmenopausal women with osteoporosis, calcium plus vitamin D modestly improved pelvic bone density but not spine, neck of femur or total hip density, and did not reduce fractures.The effects of combined calcium and vitamin D supplementation on bone mineral density and fracture risk in postmenopausa…
- This review of smartphone apps for osteoporosis self-management did not test vitamin D supplements and found no significant effect on vitamin D intake.Digital Health Technologies for Long-term Self-management of Osteoporosis: Systematic Review and Meta-analysis.
- In 108 trials with 10,655 people, Chinese herbs (often with Caltrate as comparison or background) gave inconsistent bone density results; Caltrate itself was not tested alone, and the review called benefit uncertain.Chinese herbal medicines for treating osteoporosis.
- In trials of older adults, 700 to 800 IU a day of vitamin D cut hip fracture risk by 26% and other nonvertebral fractures by 23%, while 400 IU a day gave no significant benefit.Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials.
- In 21 studies with 2,916 people with osteoporosis, Jintiange capsules reduced pain, improved bone density and cut fractures compared with usual drugs including Caltrate D3; Caltrate was not tested on its own.The effect of Jintiange capsules on pain in patients with primary osteoporosis: a systematic review and meta-analysis.
- Across nine studies, vitamin D3 did not significantly reduce nonvertebral or vertebral fractures versus placebo or calcium alone, with only a borderline trend toward fewer falls.The effect of cholecalciferol (vitamin D3) on the risk of fall and fracture: a meta-analysis.
- In 23 trials of 1,209 kidney transplant recipients, vitamin D analogues (2 trials, 51 patients) improved lumbar spine and femoral neck bone density versus no treatment, but no trial showed fewer fractures.Interventions for preventing bone disease in kidney transplant recipients: a systematic review of randomized controlled …
- In eight small trials with 644 people with osteoporosis, Erxian decoction herbal formula improved bone density more than Caltrate tablets alone, though evidence was weak.Effects of Chinese herbal formula Erxian decoction for treating osteoporosis: a systematic review.
- In 18 small trials of 576 children with chronic kidney disease, vitamin D preparations lowered parathyroid hormone levels, but there were few data on growth or bone deformities and no clear differences between preparations.Interventions for metabolic bone disease in children with chronic kidney disease.
- One small trial of 39 people with sickle cell disease found vitamin D3 for six weeks raised blood vitamin D and reduced pain days versus placebo, but no bone outcomes were reported and the evidence was low quality.Vitamin D supplementation for sickle cell disease.
- In ten trials, Qianggu Capsule plus Caltrate D raised bone density more than Caltrate D alone in people with primary osteoporosis, but study quality was low.Qianggu capsule for the treatment of primary osteoporosis: evidence from a Chinese patent medicine.
- In nine trials of postmenopausal women without osteoporosis, vitamin D raised blood vitamin D and improved some bone remodeling measures, but only one study found fewer fractures, so a fracture benefit could not be confirmed.Supplementation of vitamin D isolated or calcium-associated with bone remodeling and fracture risk in postmenopausal wom…
- In a review of 25 observational studies of healthy men aged 50 or older, evidence linking calcium intake to bone density or bone loss was inconsistent or weak.Risk factors for low BMD in healthy men age 50 years or older: a systematic review.
- In 500 elderly women with Alzheimer disease who all took 1000 IU of vitamin D2 plus calcium, adding risedronate for 18 months raised bone density 4.1% and cut hip fracture risk compared with placebo, but vitamin D itself was not tested alone and the paper was retracted.The prevention of hip fracture with risedronate and ergocalciferol plus calcium supplementation in elderly women with Al…
- Children whose mothers took 1000 IU of vitamin D3 daily during pregnancy had higher whole-body bone mineral content and density at ages 6-7 than children whose mothers took placebo.Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled…
- In 242 elderly men with Parkinson disease who all took 1000 IU of vitamin D2, adding risedronate for 2 years raised bone density, but vitamin D was not compared against placebo and the paper was retracted.Risedronate and ergocalciferol prevent hip fracture in elderly men with Parkinson disease.
- In 236 early postmenopausal women, estrogen plus progestin on top of one Caltrate-D tablet daily preserved spine bone density over 2 years, while Caltrate-D alone showed non-significant drops of 0.4% and 1.6%.[Comparative study on two different dosages of conjugated equine estrogen continuously combined with medroxyprogesterone…
- In 236 early postmenopausal women, adding estrogen to one Caltrate-D tablet daily raised spine bone density over 2 years, while Caltrate-D alone saw non-significant declines (-0.4% at 1 year, -1.6% at 2 years).A comparison of two different dosages of conjugated equine estrogen in continuous combined hormone replacement therapy w…
- In 200 older men with osteoporosis taking Caltrate-D for 12 months, Busheng Huoxue Capsule improved quality of life more than alendronate, with bone density gains similar between groups.[Effect of Busheng Huoxue Capsule on the quality of life of primary osteoporosis senile males].
- In 150 elderly Chinese women with low bone mass, 12 months of Caltrate D raised lumbar spine bone density by about 0.8%, and adding calcitriol raised it more (about 2.8%).The efficacy and safety of calcitriol and/or Caltrate D in elderly Chinese women with low bone mass.
- In 114 people with moderate fluorosis-related bone damage, 12 weeks of Caltrate 600 mg daily with or without a herbal treatment produced no meaningful X-ray improvement in either group.[X-ray analysis on 114 patients with moderate endemic skeletal fluorosis by treatment of Guo's Chinese herbal].
- In 110 postmenopausal women with low bone mass, all took Caltrate D, and those who also did eight section brocade exercise had higher spine and hip bone density than those on Caltrate D alone.Study on the effect of Western medicine caltrate D combined with traditional Chinese medicine eight section brocade prac…
- In 108 women with aromatase inhibitor-related joint pain, all of whom took Caltrate D, bone density T-scores declined in both groups over two 3-month courses with no significant difference in bone metabolism between herbal and control treatment.Effects of the efficacy of the Yi Shen Tiao Gan formula on aromatase inhibitor associated musculoskeletal syndrome: a ra…
- In 51 pairs of premenarcheal girl twins, 1200 mg of calcium carbonate daily for 2 years raised bone density at the hip and spine over the first 12 to 18 months compared with placebo, but gains were not kept at 24 months.The effect of calcium supplementation on bone density in premenarcheal females: a co-twin approach.
- In 96 people with bone death of the femoral head, adding Modified Qing'e Pill to Caltrate D for 6 months raised femoral neck bone density and lowered inflammation marker levels more than Caltrate D with a placebo pill.Effects of Modified Qing'e Pill () on expression of adiponectin, bone morphogenetic protein 2 and coagulation-related fa…
- In 91 breast cancer patients with aromatase inhibitor bone pain, adding calcitonin to Caltrate D for three months reduced pain more than Caltrate D alone but did not prevent bone density loss.Effect of calcitonin on anastrozole-induced bone pain during aromatase inhibitor therapy for breast cancer.
- In 90 older adults with osteoporotic wrist fractures, the group taking Caltrate D with calcitonin and alfacalcidol healed in about 9 weeks, faster than the group taking no medicine at about 12 weeks.[Clinical randomized controlled trial on splint external fixation combined with Chinese herbs in treating distal radius …
- In 90 postmenopausal women with osteoporosis, Caltrate D 600 mg daily for 30 days did not change bone density, while warm acupuncture reduced pain more than Caltrate D.[Clinical research on warm acupuncture therapy for pain in postmenopausal osteoporosis].
- In 85 postmenopausal women with osteoporosis, all taking 600 mg of Caltrate D daily for one year, adding warm needling produced larger increases in bone density at the spine and hip than Caltrate D alone.[Warm needling combined with element calcium for postmenopausal osteoporosis].
- In 84 older women, resistance training, Yijinjing or Baduanjin exercise combined with oral Caltrate D for 24 weeks increased lumbar spine bone density and bone formation marker levels more than Caltrate D with no exercise, but had no significant effect on hip bone density.Effects of resistance training, Yijinjing and Baduanjin exercise with oral caltrate D on bone mineral density and bone m…
- In 76 people with senile osteoporosis, Caltrate D taken alongside acupoint plaster therapy for 8 weeks improved pain, function and quality of life, but bone density was not measured.[Acupoint plaster therapy with midnight-noon ebb-flow hour-prescription method for senile osteoporosis:a randomized cont…
- In 60 people with primary osteoporosis, 600 mg daily of Caltrate for 12 weeks raised bone density, and adding spreading moxibustion to Caltrate raised it more.[Clinical study on primary osteoporosis treated with spreading moxibustion for warming yang and activating blood circula…
- In 60 elderly people with hip fractures, 600 mg daily of Caltrate D for 12 months with surgery increased lumbar and hip bone density, and adding zoledronic acid gave better pain relief and fewer new fractures.Treatment of osteoporotic intertrochanteric fractures by zoledronic acid injection combined with proximal femoral nail a…
- In 60 women with osteoporosis, adding electroacupuncture to oral Caltrate for 4 weeks shortened walking test time and improved back muscle stiffness more than Caltrate alone.[Electroacupuncture on motor function in patients with primary osteoporosis: a randomized controlled trial].
- In 60 people with osteoporosis and low muscle mass, 1200 mg daily of Caltrate for 4 weeks was given with or without thunder-fire moxibustion; adding moxibustion reduced pain and increased walking speed more, but bone density was not measured.[Effects of thunder-fire moxibustion on the motor function in the patients of osteoporosis with low skeletal muscle mass…
- In 60 women with osteoporosis and low muscle mass, adding thunder-fire moxibustion to Caltrate D for 12 weeks lowered bone turnover markers and improved balance more than Caltrate D alone.[Effects of thunder-fire moxibustion on balance function and musculoskeletal metabolism in female patients of primary os…
- In 40 women with postmenopausal osteoporosis over 3 months, Caltrate with vitamin D2 did not significantly change bone mineral density, while warm needle moxibustion raised it and gave a clearly better clinical response (35% vs 5% controlled).[Effects of warm needle moxibustion on bone mass density and biochemical indexes of bone metabolism in patients of postm…
- In 40 patients with immune thrombocytopenic purpura on meds, adding alendronate to Caltrate D for 9 months raised bone density at the spine, femoral neck and total hip more than Caltrate D alone, and lowered bone resorption markers.Read the study on PubMed (31363377) →
- In 39 older women with severe osteoporosis, 1200 mg of calcium daily with or without 25-hydroxyvitamin D for two years kept bone mineral content stable in both groups, with improved bone mineralization rate in both groups.Histomorphometric effects of calcium or calcium plus 25-hydroxyvitamin D3 therapy in senile osteoporosis.
- In 38 postmenopausal breast cancer patients on aromatase inhibitors, adding a herbal recipe to daily Caltrate D for six months increased bone density in the spine and hip, while the Caltrate D only group lost bone density.[Prevention and treatment of aromatase inhibitor-associated bone loss by shugan jiangu recipe in postmenopausal women wi…
- In 27 people with hyperthyroidism-related bone thinning, bone density rose over one year in both groups taking Caltrate D, and rose more when alendronate was added.[Clinical application of alendronate for osteoporosis/osteopenia secondary to hyperthyroidism].
- In 130 postmenopausal breast cancer patients on aromatase inhibitors, adding a herbal formula to Caltrate D for 12 months reduced bone loss compared with Caltrate D alone; this tests the herbal formula, not Caltrate itself.Effect of Jianpi Bushen formula on aromatase-inhibitor-associated bone loss after menopause.
- In 100 Chinese postmenopausal women with low vitamin D, 800 IU daily cholecalciferol plus Caltrate D for 3 months raised vitamin D levels and lowered bone turnover marker CTX, as did calcitriol plus Caltrate D.Comparison of the effects of cholecalciferol and calcitriol on calcium metabolism and bone turnover in Chinese postmenop…
- In 90 patients with gum disease, adding Xianling Gubao capsules to basic treatment increased alveolar bone density more than adding Caltrate or basic treatment alone over 6 months; the abstract does not report a separate Caltrate-versus-control bone result.Xianling Gubao capsules improve oral health, alveolar bone defects, and bone density in patients with periodontitis.
- In 40 postmenopausal women with wrist fracture, 1 g of calcium daily for one year had no significant effect on femur bone mineral content compared with placebo.Bone mineral content in women with Colles' fracture: effect of calcium supplementation.
- In 35 postmenopausal women with osteoporosis, a single evening dose of Caltrate (1.2 g calcium) raised urinary calcium and briefly lowered a bone breakdown marker, but this effect did not differ from two other calcium products and faded within 36 hours.Effects of three different calcium preparations on urinary calcium and hydroxyproline excretion in postmenopausal osteop…
- In 2904 US adults aged 60 and over, higher dietary calcium was linked with higher lumbar bone density, but this link held in women and not in men.Association between Dietary Calcium Intake and Bone Mineral Density in Older Adults.
- In 1479 elderly Japanese men, greater milk intake was linked with higher hip and femoral neck bone density and lower bone turnover, though this link weakened after accounting for calcium intake.Greater milk intake is associated with lower bone turnover, higher bone density, and higher bone microarchitecture index…
- In 1098 adults aged 65 and over, higher dietary calcium intake was linked with higher bone density at the hip and spine, while higher urinary sodium was linked with lower bone density.Dietary intake, blood pressure and osteoporosis.
- In 698 placebo-group women over 65 with osteopenia, averaging 886 mg of dietary calcium a day over 6 years, calcium intake was unrelated to bone loss at any site.Dietary Calcium Intake and Bone Loss Over 6 Years in Osteopenic Postmenopausal Women.
- In a survey of 452 women in Alaska, dietary calcium intake was low (about 306 mg a day on average), but the survey did not test calcium supplements, so it shows no effect of calcium on bone.Risk factors for osteoporosis in Alaska Native women: a cross-sectional survey.
- In Tuscany, Italy, most people who broke a hip from 2011 to 2015 were not taking vitamin D supplements, and only 30-35% were on cholecalciferol one year after the fracture; no bone outcome was measured against a comparison group.The use of cholecalciferol in patients with hip fracture.
- Among 173 adults aged 35 to 50, about a quarter had osteopenia; bone density correlated with exercise in women and in the opposite direction in men, and no calcium-specific result was reported.Bone Mineral Density Among Men and Women Aged 35 to 50 Years.
- In a 2-year cross-sectional study of 116 pre- and post-menopausal obese and non-obese women, daily vitamin D and calcium intake was low and osteoporosis was less common in obese women, though blood vitamin D levels were within normal range.Dietary Pattern and Bone Health in Pre and Post-menopausal Obese Women.
- In 52 Parkinson's patients compared with 52 matched controls, lower bone density was seen, and insufficient calcium intake was among the factors related to low bone density.Prevalence and risk factors of osteoporosis in patients with Parkinson's disease.
- In 70 people taking meds, a dedicated bone clinic found many with bone loss; early results showed bone density rose 3 to 5 percent with drug and lifestyle measures, including calcium and/or vitamin D in 44 people.Read the study on PubMed (10678299) →
- In 67 postmenopausal women with osteoporosis taking alendronate and Caltrate 600 mg daily for one year, bone density response depended on osteoprotegerin gene variants, with carriers of the G allele responding less well.[Osteoprotegerin gene polymorphism and therapeutic response to alendronate in postmenopausal women with osteoporosis].
- In 60 postmenopausal women with acute spinal compression fractures, teriparatide plus Caltrate calcium and vitamin D gave pain and quality-of-life gains similar to vertebroplasty at lower cost, but vertebral height rose only with vertebroplasty.Effects of teriparatide versus percutaneous vertebroplasty on pain relief, quality of life and cost-effectiveness in pos…
- In 42 Iranian adults with hemophilia, low bone density was very common, and only cigarette smoking was significantly linked to it, not calcium intake.Bone mineral density in hemophilia patients.
- In 28 children with lupus, 3 months of Caltrate calcium (600 mg twice daily) plus vitamin D3 did not significantly change bone density, though 17 children improved on disease activity and autoimmune markers.Vitamin D status in children with systemic lupus erythematosus and its association with clinical and laboratory paramete…
Review Totals and Summary
Members Only17,338 reviews · 95% positive
Caltrate 600+D3 tablets are well liked overall, with most buyers rating them 4 or 5 stars. The product carries about 17,338 ratings across the stores. Buyers mostly praise it as a trusted, affordable calcium and vitamin D supplement, and the main complaints are tablet size and short expiry dates on some orders. **What buyers say it did for them:** Many describe it as a dependable bone-health supplement they have taken for years. One says it "keeps my bones healthy and strong," another "normalized my calcium," and a third simply says "Works well. Have used for years." Several mention that a doctor recommended it. One buyer credits it for surviving three falls without a broken bone. Store summaries also mention that it meets calcium and vitamin D needs and is a practical way to support bone health. **What they complain about:** The most specific complaints concern short-dated stock. One buyer received a package "only 3 months out," another got two bottles that were too close to expiring, and a third reported "Expires April and May 2024." One reviewer speculated that a heavily discounted item would be short dated. A single reviewer received a bottle sent without a cap. One store summary notes a one-star review objecting to the Red 40 Lake dye and to the manufacturer named on the bottle. Another review simply asks "why are the tablets pink?" **Taste, smell, pill size and form:** Size is the most mixed point. Many call the tablets easy to swallow: "I prefer the Caltrate calcium, it is very easy to swallow." Others find them big: "Big pills, but easy to swallow." One says "My only problem is how large they are," and a store summary mentions a one-star review from someone who could not swallow them at all. Two reviewers say the tablets can be cut in half, one of them preferring that to "chalky tasting gummies." One says it is "not too big and only have to take 2." A store summary says the tablets leave no aftertaste. **Value for money:** Price is a frequent positive. Reviewers write "Great price. Great brand," and "cheaper than what I was paying in the store." A Canadian buyer finds it a "real deal" compared with the smaller bottles sold locally. Another says it is a "Great Price!!" for a supplement they take every day. Store summaries also describe it as affordable and good value, and some praise fast, intact delivery. **Who it seems to suit and who it did not:** It suits people who want a familiar, doctor-recommended calcium plus D3 tablet at a low price and who can manage a large pill, or who are willing to split it. Long-term users cite brand trust: "its a brand i trust." It suits less well anyone who struggles with large tablets, avoids synthetic dyes, or buys online and needs a long shelf life, since several buyers received stock close to expiry. This summary covers the tablets only. Any reviews of other forms were left out.
Biohacker Summary
Members Only8 of 10 recommend it
On calcium, the main ingredient, the panel is mostly neutral rather than enthusiastic: three of the ten recommend it, six are neutral and one warns. Those who recommend it say it matters for bone, nerves, muscles and the heart, and one suggests 1,000 to 1,200 milligrams a day, which can come from calcium carbonate or calcium citrate. Several others mainly point to food sources such as dairy, sardines and kale, or note that diets often fall short on calcium, and one is still weighing whether he needs a supplement. The one caution is that bone loss cannot be fixed with calcium alone, because bone also depends on collagen and other minerals. Vitamin D is a smaller ingredient in this product, and the panel speaks of it warmly, with several taking 5,000 IU a day or more and many urging that blood levels be checked.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Calcium · warns
- Warns that bone loss cannot be fixed with just calcium, as bone is primarily collagen with other essential minerals.
- Dr. Berg warns that the recommended daily intake for vitamin D is based on a massive error and that the actual necessary amount is closer to 8,895 IU, with millions remaining deficient.
- Recommends getting vitamin D levels tested to ensure they are between 50 and 70, as vitamin D is intimately involved in regulating prostate size.
- Recommends taking at least 10,000 IUs of vitamin D3 every single day in the winter, stating it is the most important vitamin to lower cancer risk.
- Recommends vitamin D to support the immune system, aiming for blood levels between 80 to 100 ng per ml.
- Recommends taking no less than 10,000 IU's of vitamin D3 for osteoporosis, alongside magnesium and K2.
- Recommends increasing vitamin D to restore balance and support healthy blood pressure.
- States that a lack of vitamin D can potentially cause achy bones or crashing mood.
- States that vitamin D is intimately involved in the immune system and recommends taking at least 10,000 IUs each day.
- States that taking high doses of vitamin D3 for 14 days can improve mood, sleep, low back pain, skin issues, and blood pressure, as well as act as a natural anti-inflammatory and reduce susceptibility to sickness.
- Mentions that grass-fed liver has vitamin D.
- Dr. Berg includes calcium carbonate among the synthetic supplements to avoid.
- Warns against calcium carbonate, also known as limestone, stating that while it lowered hip fractures in a study, it also increased kidney stones and is not good for arteries, requiring the body to work hard to use it.
- Notes that tannins in tea bind calcium, blocking its absorption.
Siim Land · Calcium · neutral
- Lists dairy and sardines as sources of Calcium.
- Advises against taking vitamin D in the morning with other supplements because it is fat soluble and requires dietary fat for better absorption.
- Recommends taking Vitamin D with fat for better absorption.
- States that Vitamin D connects biology to light and that UVB reaching the skin enables its production.
- Thinks vitamin D has some of the strongest evidence and is worth considering.
- Notes that Vitamin K2 pairs well with vitamin D by regulating calcium and bone mineralization.
- Recommends taking vitamin D supplements with some fat to maximize its absorption, suggesting with food or a teaspoon of olive oil.
- Notes that taking vitamin D3 with a fat-containing meal resulted in 32% higher peak blood vitamin D levels.
- Recommends taking Vitamin D in the morning or at lunch with fat.
- Notes that Boron reduces calcium/magnesium loss.
- Notes that Boron improves vitamin D.
- Recommends Vitamin D because microglia contain Vitamin D receptors, and Vitamin D helps keep the immune system properly regulated, with low levels associated with greater neuroinflammation and a higher risk of autoimmune conditions.
- Recommends a high calcium intake for bone health.
- Places calcium supplementation in the 'bad tier' due to its association with increased cardiovascular events, recommending dairy or bones as easier ways to get calcium, though it can be useful for postmenopausal women with low bone density.
Thomas DeLauer · Calcium · neutral
- Notes that milk contains 120mg of calcium, while sardines contain 351mg, highlighting a 3x difference.
- Uses vitamin D3 in the fall and winter months when getting less sun, as it's important to supplement it then.
- Recommends taking a massive amount of vitamin D simultaneously with an early morning massive breakfast to help reset circadian rhythms and address hyperphagia.
- Recommends Vitamin D, stating that it has receptors throughout the brain and deficiency can quickly impact brain and mood.
- Takes supplemental vitamin D because he is skin sensitive and from northern latitudes, limiting his UV exposure.
- Recommends taking vitamin D on non-liver days to ensure both nutrients get proper receptor access.
- Takes Purity's liquid vitamin D3 with K2 because she is constantly inside during the day; D3 is for overall wellness and K2 helps the body absorb calcium properly.
- Recommends getting vitamin D, suggesting it can be obtained while walking.
- States that vitamin D is best obtained from the sun, but getting it from food definitely helps, and notes its role as a hormone influencing many cells.
- Recommends D3, suggesting a dose of 2000-4000 IU, and notes that MK-7 slowed bone loss over three years.
- Recommends vitamin D, especially for Hashimoto's, explaining that it drives T reg expansion to suppress autoimmune responses that attack the thyroid, and notes that vitamin D and selenium deficiencies often co-occur.
- Recommends getting calcium, along with vitamin D, zinc, and magnesium, from foods like sardines, as they are important for inflammatory pathways in the gut.
- Explains that eating sardines with their soft bones provides a serious hit of calcium, which is a perfect combination for bones and may contribute to satiety.
- Mentions that magnesium and calcium should not be taken together as they cancel each other out.
Dr. Mark Hyman · Calcium · recommends
- Notes that calcium is in bones but is also essential for nerves, muscles, and the heart, and low levels can affect muscle function and heart rhythm.
- Recommends Vitamin D for health, stating that amazing things happen when patients' vitamin D statuses reach optimal levels.
- Mentions vitamin D as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
- Notes that vitamin D plays a role in immune function.
- Recommends checking vitamin D levels and states that if they had to pick one single intervention for immune health, vitamin D would be it.
- Dr. Hyman discusses vitamin D in relation to sun exposure patterns.
- States that vitamin D supplementation can help with oxidative stress.
- Mentions vitamin D as a key nutrient for supporting immune function.
- States that vitamin D is probably the single most important intervention for immune health, recommending levels of 45 to 70 and emphasizing testing to determine the right dose.
- Notes that rickets, which causes terrible bone deformities, is caused by vitamin D deficiency.
- Notes that vitamin D is an important nutrient for brain performance and aging, and that many people have gaps in these nutrients.
- States that green leafy vegetables are great sources of calcium.
- Notes that calcium needs are lower than advertised and that stress, soda, and excess sugar can drive calcium loss.
- Does not prescribe calcium supplements at all, teaching people to get it from whole foods instead, because calcium supplements don't work for building bones or preventing fractures, and it's bone quality, not density, that matters.
Dr. Rhonda Patrick · Calcium · neutral
- Mentions that kale delivers calcium, a micronutrient many diets fall short on.
- Vitamin D supplementation was linked to a 40% lower risk of dementia in an observational study of more than 12,000 older adults.
- Mentions that vitamin D also plays a role in maintaining muscle mass.
- Recommends ensuring adequate vitamin D intake for men's sperm health.
- Vitamin D and strength training alone did not, but adding them strengthened the effect on one clock, with the full combination slowing that measure by ~3.8 months.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Recommends Vitamin D, noting it regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity, and correcting deficiency may slow epigenetic aging.
- Uses Vitamin D3 as an example of a supplement that an AI model could track to see its impact on other metrics like glucose levels.
- Recommends Vitamin D, explaining that it regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity.
- Combining omega-3s with vitamin D and exercise has an additive effect, translating to ~3 months of slowed biological aging.
- The effect got stronger when omega-3 was combined with vitamin D and resistance training, with the full stack delaying phenotypic aging by about 3.8 months.
- Notes additional gaps in calcium.
- Reports that alcohol use disorder is associated with a 20-50% greater prevalence of Calcium deficiency.
- Around 38% doesn't meet the requirement for calcium.
Dave Asprey · Calcium · neutral
- Notes that when energy intake is too low for training demand, nutrient intake often falls short, especially for calcium, which is associated with reduced bone health.
- Takes Vitamin DAKE from Suppgrade Labs.
- Suggests that vitamin D supports brain health, muscle function, and focus.
- Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense for male fertility, even though supplementation did not improve overall semen parameters in a randomized trial.
- States that currently, he is only taking vitamin C and vitamin D.
- Recommends vitamin D, noting it's actually a hormone and that most people are deficient, even those who take it, because they don't take enough.
- States that most people on the spectrum are low in vitamin D and need more of it, mentioning his own product, Vitam DAKNE, which contains real vitamin A.
- Dave Asprey recommends Vitamin D3 with K2, explaining D3 is a hormone made from sunlight and K2 directs calcium into bones, not arteries, highlighting its low cost, widespread deficiency, and the ability to test its effectiveness.
- Recommends Vitamin D as one of the most important supplements for overall health.
- Takes Vitamin DAKE from Suppgrade Labs because D3, A, K2, and E work together.
- Mentions taking vitamin D in the morning, comparing it to the daily dosing of testosterone.
- Explains that calcium provides the raw material for bones, but it isn't a standalone input and needs a whole system to be effective.
- Notes that people take calcium for their bones.
- Warns that taking calcium without vitamin D, A, and K2 can lead to calcium going into tissues, causing bone spurs and other issues, and recommends a two-to-one ratio of calcium to magnesium.
Ben Greenfield · Calcium · neutral
- Is considering whether he needs a calcium supplement because lead can displace calcium in bones, affecting bone strength.
- Notes that Vitamin D is actually a hormone and recommends patients aim for levels around 40 to 50, or even 60 for fracture healing, for optimal healing, as opposed to just above 20 which is considered normal.
- Mentions vitamin D as part of a bare-minimum protocol.
- Advises getting vitamin D levels between 60 and 100 nanograms per milliliter as a minimum step for overall health and to slow down heart disease.
- Has been taking Vitamin D3 K2 for over a decade.
- Notes that sunlight influences more than just vitamin D production.
- Recommends keeping vitamin D levels high, suggesting that a supplement is probably not a bad idea, especially given that many people are deficient due to spending most of their time indoors.
- Recommends getting enough vitamin D for blood pressure management.
- Recommends optimizing vitamin D levels to a serum score of around 50 to 80 nanograms per milliliter, as deficiency is linked to tinnitus volume and can assist with it.
- Recommends using hormone building blocks like vitamin D for hormone optimization.
- Mentions calcium as a common deficiency.
- Notes that vitamin D deficiency is the most common deficiency.
- Recommends adequate intake of calcium for bone strength.
- Is using calcium chloride mixed with PRP before injecting for the P-shot.
Peter Attia · Calcium · recommends
- Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
- Lists vitamin D as one of her staple supplements.
- Notes that several studies show patients taking vitamin D can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
- States that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin D for both sexes.
- Uses vitamin D as an example of how people might dismiss its efficacy due to failed clinical trials that didn't adjust the dose or measure levels.
- In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin D for both sexes.
- Suggests that supplementing with lots of vitamin D might help overcome the negative effects of phenytoin on bone health by improving calcium absorption, though he is unaware of studies on this.
- Recommends Vitamin D3 as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 800 to 1,000 IU, which can be obtained through sunlight or supplementation.
- Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
- Suggests that supplementing with lots of vitamin D might overcome the negative effects of phenytoin on bone health by counteracting increased catabolism of vitamin D and subsequent decreased calcium absorption.
- Recommends vitamin D for people who tend to be vitamin D deficient, such as those living in Portland, Oregon.
- Discusses evaluating vitamin D, understanding deficiency, and optimal levels.
- Recommends calcium for bone health, stating that teenagers probably need about 1000 milligrams a day.
- Discusses bone acting as a reservoir for calcium and how resorption and formation release calcium into the blood when needed.
Bryan Johnson · Calcium · recommends
- Recommends calcium as a mineral that, along with phosphorus, magnesium, and boron, is deposited to fortify the bone structure after the collagen scaffold is in place.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Mentions that the sunlight assessment claims low vitamin D levels cause the immune system to misfire, and notes that their vitamin D has been measured.
- Takes 5000 IU of Vitamin D3 in the morning for longevity.
- He takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 5,000 IU of Vitamin D3 in the morning for longevity.
- Takes 5,000 IU of Vitamin D3 in the morning.
- Takes 5,000 IU of Vitamin D3 in the morning.
- He takes 5000 IU of Vitamin D3 in the morning for general health.
- Agrees that a little extra calcium is probably okay, especially for women, to really hit home for bone mineral density.
- Recommends prioritizing calcium intake for postmenopausal women to help maintain bone density and reduce the risk of osteoporosis.
- Bryan Johnson takes Calcium daily as part of his Longevity Mix, which supports healthy bones and teeth.
Andrew Huberman · Calcium · neutral
- Discusses "hard water" and the role of magnesium and calcium in cardiovascular health.
- Notes that most people are probably deficient in vitamin D and benefit from supplementing, but there's no point in doing it unless you're deficient for most things.
- Takes 5,000 IU of Vitamin D3 in the morning for longevity.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- States that Vitamin D is one of the critical nutrients with the best evidence for cognitive function and reducing the risk of dementia.
- Takes 5000 IU of Vitamin D3 in the morning.
- He takes 5,000 IU of Vitamin D3 in the morning for overall health.
- Takes 5000 IU of Vitamin D3 in the morning.
- Takes 5,000 IU of Vitamin D3 in the morning for general health.
- Takes 5000 IU of Vitamin D3 every day for longevity.
- Takes 5,000 IU of Vitamin D3 in the morning.
- Adequate intake of calcium is vital for bone health.
RAL Summary
Members OnlyTier 2 for Bone Health
Multiple controlled trials of this exact product show bone density gains in older adults and people with osteoporosis [1][3], and 95 percent of over 17,000 reviews are positive, meeting tier 2.
This product itself was tested in 35 human studies.
Where the evidence disagrees: 15 of the 60 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Skeletal system, Endocrine system
Combine with: For bone health, pair Caltrate 600+D3 with vitamin K2 (MK-7) to help direct calcium into bone rather than soft tissue, and magnesium (glycinate or citrate) to support calcium metabolism and vitamin D activation. Take it with meals, since calcium carbonate needs stomach acid for absorption, and separate it from iron, meds, and some meds by a few hours. Collagen peptides or boron may add further skeletal support. If blood sugar support is the actual goal, choose a separate product with berberine, chromium picolinate, or alpha-lipoic acid, and consult a healthcare provider, especially if taking meds.
Possible side effects: No major side effects reported in the studies; some buyers find the tablets large and hard to swallow, and one objected to the red dye.
Supplement Facts
Vitamin D3 800 IU · Calcium 600 mg
| Vitamin D3 | 800 IU | |
| Calcium | 600 mg |
Other ingredients: Calcium Carbonate, Maltodextrin, Contains Less Than 2% of.
Directions: Suggested use: Adults: Take one (1) tablet up to two times daily with food or as directed by your physician. Take with a full glass of water.
Label source: NIH label database · Report a label change
Show entire label

More bone health products
Members OnlyThe highest ranked for the same goal
Read more
Our articles on this subject
- Peter Attia's Supplement List: What He Takes and What the Trials SayArticle · Sep 20, 2026
Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
Privacy policyConsumer health dataTermsDo Not Sell or Share My Personal InformationCookie settings

